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Publications:  Mr Barrie Peck

Kapara A, Vannini A, Peck B(2020). A micronutrient with major effects on cancer cell viability. Nature Metabolism
10.1038/s42255-020-0244-3
Peck B, Schulze A(2019). Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment. Trends in Cancer vol. 5, (11) 693-703.
10.1016/j.trecan.2019.09.007
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63787
Jones DT, Valli A, Haider S, Zhang Q, Smethurst EA, Schug ZT, Peck B, Aboagye EO et al.(2018). 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers. Molecular Cancer Therapeutics vol. 18, (2) 376-388.
10.1158/1535-7163.MCT-17-0857
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62118
Miess H, Dankworth B, Gouw AM, Rosenfeldt M, Schmitz W, Jiang M, Saunders B, Howell M et al.(2018). The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene vol. 37, (40) 5435-5450.
10.1038/s41388-018-0315-z
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62485
Leonidou A, Peck B, Natrajan R(2017). Identification and Validation of Driver Kinases from Next-Generation Sequencing Data. Methods Mol Biol vol. 1636, 179-195.
10.1007/978-1-4939-7154-1_12
Morrison E, Wai P, Leonidou A, Bland P, Khalique S, Farnie G, Daley F, Peck B et al.(2016). Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures. J Vis Exp (118)
10.3791/54738
Maguire SL, Peck B, Wai PT, Campbell J, Barker H, Gulati A, Daley F, Vyse S et al.(2016). Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model. J Pathol vol. 240, (3) 315-328.
10.1002/path.4778
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62483
Peck B, Schulze A(2016). Lipid desaturation - the next step in targeting lipogenesis in cancer?. FEBS J vol. 283, (15) 2767-2778.
10.1111/febs.13681
Peck B, Schug ZT, Zhang Q, Dankworth B, Jones DT, Smethurst E, Patel R, Mason S et al.(2016). Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments. Cancer Metab vol. 4,
10.1186/s40170-016-0146-8
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61378
Lewis CA, Brault C, Peck B, Bensaad K, Griffiths B, Mitter R, Chakravarty P, East P et al.(2015). SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme. Oncogene vol. 34, (40) 5128-5140.
10.1038/onc.2014.439
Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E et al.(2015). Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell vol. 27, (1) 57-71.
10.1016/j.ccell.2014.12.002
Bensaad K, Favaro E, Lewis CA, Peck B, Lord S, Collins JM, Pinnick KE, Wigfield S et al.(2014). Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation. Cell Rep vol. 9, (1) 349-365.
10.1016/j.celrep.2014.08.056
Peck B, Schulze A(2014). Cholesteryl esters: fueling the fury of prostate cancer. Cell Metab vol. 19, (3) 350-352.
10.1016/j.cmet.2014.02.012
Schug Z, Peck B, Jones D, Zhang Q, Alam I, Witney T, Smethurst E, Grosskurth S et al.(2014). Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress. Cancer & metabolism vol. 2, (Suppl 1) O9-O9.
10.1186/2049-3002-2-S1-O9
Baenke F, Peck B, Miess H, Schulze A(2013). Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development. Dis Model Mech vol. 6, (6) 1353-1363.
10.1242/dmm.011338
Griffiths B, Lewis CA, Bensaad K, Ros S, Zhang Q, Ferber EC, Konisti S, Peck B et al.(2013). Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth. Cancer Metab vol. 1, (1)
10.1186/2049-3002-1-3
Peck B, Ferber EC, Schulze A(2013). Antagonism between FOXO and MYC Regulates Cellular Powerhouse. Front Oncol vol. 3,
10.3389/fonc.2013.00096
Ferber EC, Peck B, Delpuech O, Bell GP, East P, Schulze A(2012). FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression. Cell Death Differ vol. 19, (6) 968-979.
10.1038/cdd.2011.179
Peck B, Schulze A(2011). A role for the cancer-associated miR-106b~25 cluster in neuronal stem cells. Aging (Albany NY) vol. 3, (4) 329-331.
10.18632/aging.100302
Peck B, Chen CY, Ho KK, Di Fruscia P, Myatt SS, Charles Coombes R, Fuchter MJ, Hsiao CD et al.(2010). SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Molecular Cancer Therapeutics vol. 9, (4) 844-855.
10.1158/1535-7163.MCT-09-0971
Kwok JM-M, Peck B, Monteiro LJ, Schwenen HDC, Millour J, Coombes RC, Myatt SS, Lam EW-F(2010). FOXM1 confers acquired cisplatin resistance in breast cancer cells. Mol Cancer Res vol. 8, (1) 24-34.
10.1158/1541-7786.MCR-09-0432
Francis RE, Myatt SS, Krol J, Hartman J, Peck B, McGovern UB, Wang J, Guest SK et al.(2009). FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer. Int J Oncol vol. 35, (1) 57-68.
10.3892/ijo_00000313
McGovern UB, Francis RE, Peck B, Guest SK, Wang J, Myatt SS, Krol J, Kwok JM-M et al.(2009). Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer. Mol Cancer Ther vol. 8, (3) 582-591.
10.1158/1535-7163.MCT-08-0805
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