Publications: Dr Benjamin Werner
Werner B, Case J, Williams MJ, Chkhaidze K, Temko D, Fernández-Mateos J, Cresswell GD, Nichol D et al.(2020).
Measuring single cell divisions in human tissues from multi-region sequencing data. Nature Communications
vol. 11,
(1)
Lakatos E, Williams MJ, Schenck RO, Cross WCH, Househam J, Zapata L, Werner B, Gatenbee C et al.(2020).
Evolutionary dynamics of neoantigens in growing tumors. Nature Genetics
vol. 52,
(10)
1057-1066.
Graham T, Caravagna G, Heide T, Williams M, Zapata L, Daniel N, Ketevan C, Cross W et al.(2020).
Subclonal reconstruction of tumors using machine learning and population genetics. Nature Genetics
vol. 52,
898-907.
Acar A, Nichol D, Fernandez-Mateos J, Cresswell GD, Barozzi I, Hong SP, Trahearn N, Spiteri I et al.(2020).
Exploiting evolutionary steering to induce collateral drug sensitivity in cancer. Nature Communications
vol. 11,
(1)
Article 1923,
Williams MJ, Zapata L, Werner B, Barnes CP, Sottoriva A, Graham TA(2020).
Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios. eLife
vol. 9,
Retel C, Kowallik V, Huang W, Werner B, Becks L, Feulner P, Huang W(2019).
The feedback between selection and demography shapes genomic diversity during coevolution. Science Advances
Chkhaidze K, Heide T, Werner B, Williams MJ, Huang W, Caravagna G, Baker A-M, Graham TA et al. (2019).
Abstract 4232: Spatially constrained tumor growth affects the patterns of clonal selection and neutral drift in cancer genomic data. 4232-4232.
Chkhaidze K, Heide T, Werner B, Williams MJ, Huang W, Caravagna G, Graham TA, Sottoriva A(2019).
Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data. PLoS Computational Biology
vol. 15,
(7)
Opasic L, Zhou D, Werner B, Dingli D, Traulsen A(2019).
How many samples are needed to infer truly clonal mutations from heterogenous tumours?. BMC Cancer
vol. 19,
(1)
Spiteri I, Caravagna G, Cresswell GD, Vatsiou A, Nichol D, Acar A, Ermini L, Chkhaidze K et al.(2019).
Evolutionary dynamics of residual disease in human glioblastoma. Annals of Oncology
vol. 30,
(3)
456-463.
Werner B, Williams MJ, Barnes CP, Graham TA, Sottoriva A(2018).
Reply to ‘Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution’. Nature Genetics
vol. 50,
(12)
1624-1626.
Heide T, Zapata L, Williams MJ, Werner B, Caravagna G, Barnes CP, Graham TA, Sottoriva A(2018).
Reply to ‘Neutral tumor evolution?’. Nature Genetics
vol. 50,
(12)
1633-1637.
Williams MJ, Werner B, Heide T, Barnes CP, Graham TA, Sottoriva A(2018).
Reply to ‘Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data’. Nature Genetics
vol. 50,
(12)
1628-1630.
Khan KH, Cunningham D, Werner B, Vlachogiannis G, Spiteri I, Heide T, Mateos JF, Vatsiou A et al.(2018).
Longitudinal liquid biopsy and mathematical modeling of clonal evolution forecast time to treatment failure in the prospect-c phase ii colorectal cancer clinical trial. Cancer Discovery
vol. 8,
(10)
Williams MJ, Werner B, Heide T, Curtis C, Barnes CP, Sottoriva A, Graham TA(2018).
Erratum to: Quantification of subclonal selection in cancer from bulk sequencing data (Nature Genetics, (2018), 50, 6, (895-903), 10.1038/s41588-018-0128-6). Nature Genetics
vol. 50,
(9)
Williams MJ, Werner B, Heide T, Curtis C, Barnes CP, Sottoriva A, Graham TA(2018).
Quantification of subclonal selection in cancer from bulk sequencing data. Nature Genetics
vol. 50,
(6)
895-903.
Werner B, Sottoriva A(2018).
Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates. PLoS Computational Biology
vol. 14,
(6)
Böttcher MA, Dingli D, Werner B, Traulsen A(2018).
Replicative cellular age distributions in compartmentalized tissues. Journal of the Royal Society Interface
vol. 15,
(145)
Williams MJ, Werner B, Barnes CP, Graham TA, Sottoriva A(2018).
Reply: Is the evolution of tumors Darwinian or non-Darwinian?. National Science Review
vol. 5,
(1)
17-19.
Huang W, Traulsen A, Werner B, Hiltunen T, Becks L(2017).
Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity. Nat Commun
vol. 8,
(1)
2059-2059.
Williams MJ, Werner B, Barnes CP, Graham TA, Sottoriva A(2017).
Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures. Nature Genetics
vol. 49,
(9)
1289-1291.
Lote H, Spiteri I, Ermini L, Vatsiou A, Roy A, McDonald A, Maka N, Balsitis M et al.(2017).
Carbon dating cancer: Defining the chronology of metastatic progression in colorectal cancer. Annals of Oncology
vol. 28,
(6)
1243-1249.
Werner B, Traulsen A, Sottoriva A, DIngli D(2017).
Detecting truly clonal alterations from multi-region profiling of tumours. Scientific Reports
vol. 7,
Sottoriva A, Graham TA, Werner B, Williams M, Barnes C (2016).
Neutral Evolution in Colorectal Cancer: How Can We Distinguish Functional from Non-functional Variation?. JOURNAL OF PATHOLOGY.
vol. 240,
7-7.
Werner B, Traulsen A, Dingli D(2016).
Response to the Editor: On the Growth of Hematopoietic Stem Cells and Childhood Leukemias. Stem Cells
vol. 34,
(10)
Hindersin L, Werner B, Dingli D, Traulsen A(2016).
Should tissue structure suppress or amplify selection to minimize cancer risk?. Biology Direct
vol. 11,
(1)
Williams MJ, Werner B, Graham TA, Sottoriva A(2016).
Functional versus non-functional intratumor heterogeneity in cancer. Molecular & Cellular Oncology
vol. 3,
(4)
e1162897-e1162897.
Werner B, Scott JG, Sottoriva A, Anderson ARA, Traulsen A, Altrock PM(2016).
The cancer stem cell fraction in hierarchically organized tumors can be estimated using mathematical modeling and patient-specific treatment trajectories. Cancer Research
vol. 76,
(7)
1705-1713.
Williams MJ, Werner B, Barnes CP, Graham TA, Sottoriva A(2016).
Identification of neutral tumor evolution across cancer types. Nature Genetics
vol. 48,
(3)
238-244.
Werner B, Traulsen A, Dingli D(2016).
Ontogenic growth as the root of fundamental differences between childhood and adult cancer. Stem Cells
vol. 34,
(3)
543-550.
Werner B, Beier F, Hummel S, Balabanov S, Lassay L, Orlikowsky T, Dingli D, Brümmendorf TH et al.(2015).
Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions. eLife
vol. 4,
(OCTOBER2015)
Werner B, Gallagher RE, Paietta EM, Litzow MR, Tallman MS, Wiernik PH, Slack JL, Willman CL et al.(2014).
Dynamics of leukemia stem-like cell extinction in acute promyelocytic leukemia. Cancer Research
vol. 74,
(19)
5386-5396.
Schulz R, Werner B, Behn U(2014).
Self-tolerance in a minimal model of the idiotypic network. Frontiers in Immunology
vol. 5,
(MAR)
Werner B, Dingli D, Traulsen A(2013).
A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues. Journal of the Royal Society Interface
vol. 10,
(85)
Huang W, Werner B, Traulsen A(2012).
The impact of random frequency-dependent mutations on the average population fitness. BMC Evolutionary Biology
vol. 12,
(1)
Werner B, Lutz D, Brümmendorf TH, Traulsen A, Balabanov S(2011).
Dynamics of resistance development to imatinib under increasing selection pressure: A combination of mathematical models and in vitro data. PLoS ONE
vol. 6,
(12)
Werner B, Dingli D, Lenaerts T, Pacheco JM, Traulsen A(2011).
Dynamics of mutant cells in hierarchical organized tissues. PLoS Computational Biology
vol. 7,
(12)