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Publications:  Dr Benjamin Werner

Werner B, Case J, Williams MJ, Chkhaidze K, Temko D, Fernández-Mateos J, Cresswell GD, Nichol D et al.(2020). Measuring single cell divisions in human tissues from multi-region sequencing data. Nature Communications vol. 11, (1)
10.1038/s41467-020-14844-6
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64507
Acar A, Nichol D, Fernandez-Mateos J, Cresswell GD, Barozzi I, Hong SP, Trahearn N, Spiteri I et al.(2020). Exploiting evolutionary steering to induce collateral drug sensitivity in cancer. Nature Communications vol. 11, (1) Article 1923,
10.1038/s41467-020-15596-z
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63761
Williams MJ, Zapata L, Werner B, Barnes CP, Sottoriva A, Graham TA(2020). Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios. eLife vol. 9,
10.7554/eLife.48714
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64534
Retel C, Kowallik V, Huang W, Werner B, Becks L, Feulner P, Huang W(2019). The feedback between selection and demography shapes genomic diversity during coevolution. Science Advances
10.1126/sciadv.aax0530
https://qmro.qmul.ac.uk/xmlui/handle/123456789/60432
Chkhaidze K, Heide T, Werner B, Williams MJ, Huang W, Caravagna G, Baker A-M, Graham TA et al. (2019). Spatially constrained tumor growth affects the patterns of clonal selection and neutral drift in cancer genomic data. CANCER RESEARCH. vol. 79,
10.1158/1538-7445.AM2019-4232
Chkhaidze K, Heide T, Werner B, Williams MJ, Huang W, Caravagna G, Graham TA, Sottoriva A(2019). Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data. PLoS Computational Biology vol. 15, (7)
10.1371/journal.pcbi.1007243
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59520
Opasic L, Zhou D, Werner B, Dingli D, Traulsen A(2019). How many samples are needed to infer truly clonal mutations from heterogenous tumours?. BMC Cancer vol. 19, (1)
10.1186/s12885-019-5597-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62989
Spiteri I, Caravagna G, Cresswell GD, Vatsiou A, Nichol D, Acar A, Ermini L, Chkhaidze K et al.(2019). Evolutionary dynamics of residual disease in human glioblastoma. Annals of Oncology vol. 30, (3) 456-463.
10.1093/annonc/mdy506
Werner B, Williams MJ, Barnes CP, Graham TA, Sottoriva A(2018). Reply to ‘Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution’. Nature Genetics vol. 50, (12) 1624-1626.
10.1038/s41588-018-0235-4
Heide T, Zapata L, Williams MJ, Werner B, Caravagna G, Barnes CP, Graham TA, Sottoriva A(2018). Reply to ‘Neutral tumor evolution?’. Nature Genetics vol. 50, (12) 1633-1637.
10.1038/s41588-018-0256-z
Williams MJ, Werner B, Heide T, Barnes CP, Graham TA, Sottoriva A(2018). Reply to ‘Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data’. Nature Genetics vol. 50, (12) 1628-1630.
10.1038/s41588-018-0210-0
Khan KH, Cunningham D, Werner B, Vlachogiannis G, Spiteri I, Heide T, Mateos JF, Vatsiou A et al.(2018). Longitudinal liquid biopsy and mathematical modeling of clonal evolution forecast time to treatment failure in the prospect-c phase ii colorectal cancer clinical trial. Cancer Discovery vol. 8, (10)
10.1158/2159-8290.CD-17-0891
Williams MJ, Werner B, Heide T, Curtis C, Barnes CP, Sottoriva A, Graham TA(2018). Erratum to: Quantification of subclonal selection in cancer from bulk sequencing data (Nature Genetics, (2018), 50, 6, (895-903), 10.1038/s41588-018-0128-6). Nature Genetics vol. 50, (9)
10.1038/s41588-018-0169-x
Williams MJ, Werner B, Heide T, Curtis C, Barnes CP, Sottoriva A, Graham TA(2018). Quantification of subclonal selection in cancer from bulk sequencing data. Nature Genetics vol. 50, (6) 895-903.
10.1038/s41588-018-0128-6
https://qmro.qmul.ac.uk/xmlui/handle/123456789/49624
Werner B, Sottoriva A(2018). Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates. PLoS Computational Biology vol. 14, (6)
10.1371/journal.pcbi.1006233
Böttcher MA, Dingli D, Werner B, Traulsen A(2018). Replicative cellular age distributions in compartmentalized tissues. Journal of the Royal Society Interface vol. 15, (145)
10.1098/rsif.2018.0272
Williams MJ, Werner B, Barnes CP, Graham TA, Sottoriva A(2018). Reply: Is the evolution of tumors Darwinian or non-Darwinian?. National Science Review vol. 5, (1) 17-19.
10.1093/nsr/nwx131
Huang W, Traulsen A, Werner B, Hiltunen T, Becks L(2017). Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity. Nat Commun vol. 8, (1) 2059-2059.
10.1038/s41467-017-01957-8
https://qmro.qmul.ac.uk/xmlui/handle/123456789/31352
Williams MJ, Werner B, Barnes CP, Graham TA, Sottoriva A(2017). Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures. Nature Genetics vol. 49, (9) 1289-1291.
10.1038/ng.3877
Lote H, Spiteri I, Ermini L, Vatsiou A, Roy A, McDonald A, Maka N, Balsitis M et al.(2017). Carbon dating cancer: Defining the chronology of metastatic progression in colorectal cancer. Annals of Oncology vol. 28, (6) 1243-1249.
10.1093/annonc/mdx074
Werner B, Traulsen A, Sottoriva A, DIngli D(2017). Detecting truly clonal alterations from multi-region profiling of tumours. Scientific Reports vol. 7,
10.1038/srep44991
Sottoriva A, Graham TA, Werner B, Williams M, Barnes C (2016). Neutral Evolution in Colorectal Cancer: How Can We Distinguish Functional from Non-functional Variation?. JOURNAL OF PATHOLOGY. vol. 240, 7-7.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18164
Werner B, Traulsen A, Dingli D(2016). Response to the Editor: On the Growth of Hematopoietic Stem Cells and Childhood Leukemias. Stem Cells vol. 34, (10)
10.1002/stem.2469
Hindersin L, Werner B, Dingli D, Traulsen A(2016). Should tissue structure suppress or amplify selection to minimize cancer risk?. Biology Direct vol. 11, (1)
10.1186/s13062-016-0140-7
Williams MJ, Werner B, Graham TA, Sottoriva A(2016). Functional versus non-functional intratumor heterogeneity in cancer. Molecular & Cellular Oncology vol. 3, (4) e1162897-e1162897.
10.1080/23723556.2016.1162897
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15910
Werner B, Scott JG, Sottoriva A, Anderson ARA, Traulsen A, Altrock PM(2016). The cancer stem cell fraction in hierarchically organized tumors can be estimated using mathematical modeling and patient-specific treatment trajectories. Cancer Research vol. 76, (7) 1705-1713.
10.1158/0008-5472.CAN-15-2069
Williams MJ, Werner B, Barnes CP, Graham TA, Sottoriva A(2016). Identification of neutral tumor evolution across cancer types. Nature Genetics vol. 48, (3) 238-244.
10.1038/ng.3489
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13290
Werner B, Traulsen A, Dingli D(2016). Ontogenic growth as the root of fundamental differences between childhood and adult cancer. Stem Cells vol. 34, (3) 543-550.
10.1002/stem.2251
Werner B, Beier F, Hummel S, Balabanov S, Lassay L, Orlikowsky T, Dingli D, Brümmendorf TH et al.(2015). Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions. eLife vol. 4, (OCTOBER2015)
10.7554/eLife.08687
Werner B, Gallagher RE, Paietta EM, Litzow MR, Tallman MS, Wiernik PH, Slack JL, Willman CL et al.(2014). Dynamics of leukemia stem-like cell extinction in acute promyelocytic leukemia. Cancer Research vol. 74, (19) 5386-5396.
10.1158/0008-5472.CAN-14-1210
Schulz R, Werner B, Behn U(2014). Self-tolerance in a minimal model of the idiotypic network. Frontiers in Immunology vol. 5, (MAR)
10.3389/fimmu.2014.00086
Werner B, Dingli D, Traulsen A(2013). A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues. Journal of the Royal Society Interface vol. 10, (85)
10.1098/rsif.2013.0349
Huang W, Werner B, Traulsen A(2012). The impact of random frequency-dependent mutations on the average population fitness. BMC Evolutionary Biology vol. 12, (1)
10.1186/1471-2148-12-160
Werner B, Lutz D, Brümmendorf TH, Traulsen A, Balabanov S(2011). Dynamics of resistance development to imatinib under increasing selection pressure: A combination of mathematical models and in vitro data. PLoS ONE vol. 6, (12)
10.1371/journal.pone.0028955
Werner B, Dingli D, Lenaerts T, Pacheco JM, Traulsen A(2011). Dynamics of mutant cells in hierarchical organized tissues. PLoS Computational Biology vol. 7, (12)
10.1371/journal.pcbi.1002290
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