Publications: Dr Benjamin Werner
Hung KL, Jones MG, Wong IT-L, Curtis EJ, Lange JT, He BJ, Luebeck J, Schmargon R et al.
(
2024
)
.
Coordinated inheritance of extrachromosomal DNAs in cancer cells
.
Nature
vol.
635
,
(
8037
)
201
-
209
.
Noorani I, Haughey M, Luebeck J, Rowan A, Grönroos E, Terenzi F, Wong IT-L, Kittel J et al.
(
2024
)
.
Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastoma
.
vol.
5
,
(
10-31
)
Moeller M, Werner B, Huang W
(
2024
)
.
Accumulating waves of random mutations before fixation
.
Physical Review E
vol.
110
,
(
4
)
Noorani I, Haughey M, Luebeck J, Rowan A, Gronroos EC, Bafna V, Huang W, Mischel P et al.
(
2024
)
.
111MO Extrachromosomal DNA drives oncogene spatial heterogeneity in IDH-wildtype glioblastomas
.
ESMO Open
vol.
9
,
Kayhanian H, Cross W, van der Horst SEM, Barmpoutis P, Lakatos E, Caravagna G, Zapata L, Van Hoeck A et al.
(
2024
)
.
Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer
.
Nature Genetics
vol.
56
,
(
7
)
1420
-
1433
.
Yu L, Renton J, Burian A, Khachaturyan M, Bayer T, Kotta J, Stachowicz JJ, DuBois K et al.
(
2024
)
.
A somatic genetic clock for clonal species
.
Nature Ecology & Evolution
vol.
8
,
(
7
)
1327
-
1336
.
Moeller ME, Mon Père NV, Werner B, Huang W
(
2024
)
.
Measures of genetic diversification in somatic tissues at bulk and single-cell resolution
.
eLife
vol.
12
,
Li H, Yang Z, Tu F, Deng L, Han Y, Fu X, Wang L, Gu D et al.
(
2023
)
.
Mutation divergence over space in tumour expansion
.
Journal of The Royal Society Interface
vol.
20
,
(
208
)
Cereser B, Yiu A, Tabassum N, Del Bel Belluz L, Zagorac S, Ancheta KRZ, Zhong R, Miere C et al.
(
2023
)
.
The mutational landscape of the adult healthy parous and nulliparous human breast
.
Nature Communications
vol.
14
,
(
1
)
Zapata L, Caravagna G, Williams MJ, Lakatos E, AbdulJabbar K, Werner B, Chowell D, James C et al.
(
2023
)
.
Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors
.
Nature Genetics
vol.
55
,
(
3
)
451
-
460
.
Househam J, Heide T, Cresswell GD, Spiteri I, Kimberley C, Zapata L, Lynn C, James C et al.
(
2022
)
.
Phenotypic plasticity and genetic control in colorectal cancer evolution
.
Nature
vol.
611
,
(
7937
)
744
-
753
.
Lange JT, Rose JC, Chen CY, Pichugin Y, Xie L, Tang J, Hung KL, Yost KE et al.
(
2022
)
.
The evolutionary dynamics of extrachromosomal DNA in human cancers
.
Nature Genetics
vol.
54
,
(
10
)
1527
-
1533
.
Tari H, Kessler K, Trahearn N, Werner B, Vinci M, Jones C, Sottoriva A
(
2022
)
.
Quantification of spatial subclonal interactions enhancing the invasive phenotype of pediatric glioma
.
Cell Reports
vol.
40
,
(
9
)
Werner B
(
2021
)
.
Shining light on dark selection in healthy human tissues
.
Nature Genetics
vol.
53
,
(
11
)
1525
-
1526
.
Reusch TBH, Baums IB, Werner B
(
2021
)
.
Evolution via somatic genetic variation in modular species
.
Trends in Ecology & Evolution
Graham T, Eszter L, Marc W, Ryan S, William C, Jacob H, Luis Z, Benjamin W et al.
(
2020
)
.
Evolutionary dynamics of neoantigens in growing tumours
.
Nature Genetics
Graham T, Caravagna G, Heide T, Williams M, Zapata L, Daniel N, Ketevan C, Cross W et al.
(
2020
)
.
Subclonal reconstruction of tumors using machine learning and population genetics
.
Nature Genetics
vol.
52
,
898
-
907
.
Acar A, Nichol D, Fernandez-Mateos J, Cresswell GD, Barozzi I, Hong SP, Trahearn N, Spiteri I et al.
(
2020
)
.
Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
.
Nature Communications
vol.
11
,
(
1
)
Article
1923
,
Williams MJ, Zapata L, Werner B, Barnes CP, Sottoriva A, Graham TA
(
2020
)
.
Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios
.
eLife
vol.
9
,
Werner B, Case J, Williams MJ, Chkhaidze K, Temko D, Fernández-Mateos J, Cresswell GD, Nichol D et al.
(
2020
)
.
Measuring single cell divisions in human tissues from multi-region sequencing data
.
Nature Communications
vol.
11
,
(
1
)
Pichugin Y, Huang W, Werner B
(
2019
)
.
Stochastic dynamics of extra-chromosomal DNA
.
Retel C, Kowallik V, Huang W, Werner B, Becks L, Feulner P, Huang W
(
2019
)
.
The feedback between selection and demography shapes genomic diversity during coevolution
.
Science Advances
Chkhaidze K, Heide T, Werner B, Williams MJ, Huang W, Caravagna G, Graham TA, Sottoriva A
(
2019
)
.
Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data
.
PLOS Computational Biology
vol.
15
,
(
7
)
Chkhaidze K, Heide T, Werner B, Williams MJ, Huang W, Caravagna G, Baker A-M, Graham TA et al.
(
2019
)
.
Abstract 4232: Spatially constrained tumor growth affects the patterns of clonal selection and neutral drift in cancer genomic data
.
Cancer Research
.
vol.
79
,
4232
-
4232
.
Opasic L, Zhou D, Werner B, Dingli D, Traulsen A
(
2019
)
.
How many samples are needed to infer truly clonal mutations from heterogenous tumours?
.
BMC Cancer
vol.
19
,
(
1
)
Caravagna G, Heide T, Williams M, Zapata L, Nichol D, Chkhaidze K, Cross W, Cresswell GD et al.
(
2019
)
.
Model-based tumor subclonal reconstruction
.
Werner B, Case J, Williams MJ, Chkhaidze K, Temko D, Fernandez-Mateos J, Cresswell GD, Nichol D et al.
(
2019
)
.
Measuring single cell divisions in human cancers from multi-region sequencing data
.
Lakatos E, Williams MJ, Schenck RO, Cross WCH, Househam J, Werner B, Gatenbee C, Robertson-Tessi M et al.
(
2019
)
.
Evolutionary dynamics of neoantigens in growing tumours
.
Spiteri I, Caravagna G, Cresswell GD, Vatsiou A, Nichol D, Acar A, Ermini L, Chkhaidze K et al.
(
2018
)
.
Evolutionary dynamics of residual disease in human glioblastoma
.
Annals of Oncology
vol.
30
,
(
3
)
456
-
463
.
Werner B, Williams MJ, Barnes CP, Graham TA, Sottoriva A
(
2018
)
.
Reply to ‘Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution’
.
Nature Genetics
vol.
50
,
(
12
)
1624
-
1626
.
Heide T, Zapata L, Williams MJ, Werner B, Caravagna G, Barnes CP, Graham TA, Sottoriva A
(
2018
)
.
Reply to ‘Neutral tumor evolution?’
.
Nature Genetics
vol.
50
,
(
12
)
1633
-
1637
.
Khan KH, Cunningham D, Werner B, Vlachogiannis G, Spiteri I, Heide T, Mateos JF, Vatsiou A et al.
(
2018
)
.
Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial
.
Cancer Discovery
vol.
8
,
(
10
)
1270
-
1285
.
Williams MJ, Werner B, Heide T, Barnes CP, Graham TA, Sottoriva A
(
2018
)
.
Reply to ‘Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data’
.
Nature Genetics
vol.
50
,
(
12
)
1628
-
1630
.
Böttcher MA, Dingli D, Werner B, Traulsen A
(
2018
)
.
Replicative cellular age distributions in compartmentalized tissues
.
Journal of The Royal Society Interface
vol.
15
,
(
145
)
Williams MJ, Werner B, Heide T, Curtis C, Barnes CP, Sottoriva A, Graham TA
(
2018
)
.
Author Correction: Quantification of subclonal selection in cancer from bulk sequencing data
.
Nature Genetics
vol.
50
,
(
9
)
1342
-
1342
.
Werner B, Sottoriva A
(
2018
)
.
Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates
.
PLOS Computational Biology
vol.
14
,
(
6
)
Williams MJ, Werner B, Heide T, Curtis C, Barnes CP, Sottoriva A, Graham TA
(
2018
)
.
Quantification of subclonal selection in cancer from bulk sequencing data
.
Nature Genetics
vol.
50
,
(
6
)
895
-
903
.
Böttcher MA, Werner B, Dingli D, Traulsen A
(
2018
)
.
Replicative cellular age distributions in compartmentalised tissues
.
Heide T, Zapata L, Williams MJ, Werner B, Barnes CP, Graham TA, Sottoriva A
(
2018
)
.
Reply: Neutral tumor evolution?
.
Williams MJ, Werner B, Barnes CP, Graham TA, Sottoriva A
(
2018
)
.
Reply: Is the evolution of tumors Darwinian or non-Darwinian?
.
National Science Review
vol.
5
,
(
1
)
17
-
19
.
Huang W, Traulsen A, Werner B, Hiltunen T, Becks L
(
2017
)
.
Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity
.
Nat Commun
vol.
8
,
(
1
)
2059
-
2059
.
Williams MJ, Werner B, Barnes CP, Graham TA, Sottoriva A
(
2017
)
.
Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures
.
Nature Genetics
vol.
49
,
(
9
)
1289
-
1291
.
Werner B, Traulsen A, Sottoriva A, Dingli D
(
2017
)
.
Detecting truly clonal alterations from multi-region profiling of tumours
.
Scientific Reports
vol.
7
,
(
1
)
Lote H, Spiteri I, Ermini L, Vatsiou A, Roy A, McDonald A, Maka N, Balsitis M et al.
(
2017
)
.
Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer
.
Annals of Oncology
vol.
28
,
(
6
)
1243
-
1249
.
Williams MJ, Werner B, Curtis C, Barnes CP, Sottoriva A, Graham TA
(
2016
)
.
Quantification of subclonal selection in cancer from bulk sequencing data
.
Werner B, Traulsen A, Dingli D
(
2016
)
.
Response to the Editor: On the Growth of Hematopoietic Stem Cells and Childhood Leukemias
.
Stem Cells
vol.
34
,
(
10
)
2610
-
2610
.
Hindersin L, Werner B, Dingli D, Traulsen A
(
2016
)
.
Should tissue structure suppress or amplify selection to minimize cancer risk?
.
Biology Direct
vol.
11
,
(
1
)
Williams MJ, Werner B, Graham TA, Sottoriva A
(
2016
)
.
Functional versus non-functional intratumor heterogeneity in cancer
.
Molecular & Cellular Oncology
vol.
3
,
(
4
)
e1162897
-
e1162897
.
Werner B, Scott JG, Sottoriva A, Anderson ARA, Traulsen A, Altrock PM
(
2016
)
.
The Cancer Stem Cell Fraction in Hierarchically Organized Tumors Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories
.
Cancer Research
vol.
76
,
(
7
)
1705
-
1713
.
Williams MJ, Werner B, Barnes CP, Graham TA, Sottoriva A
(
2016
)
.
Identification of neutral tumor evolution across cancer types
.
Nature Genetics
vol.
48
,
(
3
)
238
-
244
.
Sottoriva A, Graham TA, Werner B, Williams M, Barnes C
(
2016
)
.
Neutral Evolution in Colorectal Cancer: How Can We Distinguish Functional from Non-functional Variation?
.
JOURNAL OF PATHOLOGY
.
vol.
240
,
7
-
7
.
Werner B, Traulsen A, Dingli D
(
2015
)
.
Ontogenic growth as the root of fundamental differences between childhood and adult cancer
.
Stem Cells
vol.
34
,
(
3
)
543
-
550
.
Bouillon A-S, Ferreira MS, Werner B, Hummel S, Panse JP, Reinecke P, Schemenau J, Haas R et al.
(
2015
)
.
Comprehensive Analysis of Telomere Biology in Patients with Aplastic Anemia and Hypoplastic Myelodysplastic Syndrome: Further Evidence for a Common Mechanism
.
Blood
vol.
126
,
(
23
)
Werner B, Beier F, Hummel S, Balabanov S, Lassay L, Orlikowsky T, Dingli D, Brümmendorf TH et al.
(
2015
)
.
Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions
.
eLife
vol.
4
,
Werner B, Gallagher RE, Paietta EM, Litzow MR, Tallman MS, Wiernik PH, Slack JL, Willman CL et al.
(
2014
)
.
Dynamics of Leukemia Stem-like Cell Extinction in Acute Promyelocytic Leukemia
.
Cancer Research
vol.
74
,
(
19
)
5386
-
5396
.
Schulz R, Werner B, Behn U
(
2014
)
.
Self-Tolerance in a Minimal Model of the Idiotypic Network
.
Frontiers in Immunology
vol.
5
,
Werner B, Dingli D, Traulsen A
(
2013
)
.
A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues
.
Journal of The Royal Society Interface
vol.
10
,
(
85
)
Glauche I, Bystrykh L, Eaves C, Roeder I, participants O
(
2013
)
.
Stem cell clonality — Theoretical concepts, experimental techniques, and clinical challenges
.
Blood Cells Molecules and Diseases
vol.
50
,
(
4
)
232
-
240
.
Huang W, Werner B, Traulsen A
(
2012
)
.
The impact of random frequency-dependent mutations on the average population fitness
.
BMC Ecology and Evolution
vol.
12
,
(
1
)
Werner B, Lutz D, Brümmendorf TH, Traulsen A, Balabanov S
(
2011
)
.
Dynamics of Resistance Development to Imatinib under Increasing Selection Pressure: A Combination of Mathematical Models and In Vitro Data
.
PLOS ONE
vol.
6
,
(
12
)
Werner B, Dingli D, Lenaerts T, Pacheco JM, Traulsen A
(
2011
)
.
Dynamics of Mutant Cells in Hierarchical Organized Tissues
.
PLOS Computational Biology
vol.
7
,
(
12
)