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Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Miguel Ganuza Fernandez

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Sá da Bandeira D, Nevitt CD, Segato Dezem F, Marção M, Liu Y, Kelley Z, DuBose H, Chabot A et al. ( 2024 ) . NR4A1 and NR4A2 orphan nuclear receptors regulate endothelial-to-hematopoietic transition in mouse hematopoietic stem cell specification . Development vol. 151 , ( 22 )
Sánchez-Lanzas R, Barclay J, Hardas A, Kalampalika F, Jiménez-Pompa A, Gallipoli P, Ganuza M ( 2024 ) . A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones . Leukemia1 - 13 .
Sánchez-Lanzas R, Jiménez-Pompa A, Ganuza M ( 2024 ) . The evolving hematopoietic niche during development . Frontiers in Molecular Biosciences vol. 11 ,
Ganuza M, Morales-Hernández A, Van Huizen A, Chabot A, Hall T, Caprio C, Finkelstein D, Kilimann MW et al. ( 2024 ) . Neurobeachin regulates hematopoietic progenitor differentiation and survival by modulating Notch activity . Blood Advances vol. 8 , ( 15 ) 4129 - 4143 .
Gorur V, Kranc KR, Ganuza M, Telfer P ( 2023 ) . Haematopoietic stem cell health in sickle cell disease and its implications for stem cell therapies and secondary haematological disorders . Blood Reviews vol. 63 ,
Ganuza M, Hall T, Myers J, Nevitt C, Sánchez-Lanzas R, Chabot A, Ding J, Kooienga E et al. ( 2022 ) . Murine foetal liver supports limited detectable expansion of life-long haematopoietic progenitors . Nature Cell Biology vol. 24 , ( 10 ) 1475 - 1486 .
Bogeska R, Mikecin A-M, Kaschutnig P, Fawaz M, Büchler-Schäff M, Le D, Ganuza M, Vollmer A et al. ( 2022 ) . Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging . Cell Stem Cell vol. 29 , ( 8 ) 1273 - 1284.e8 .
Sánchez‐Lanzas R, Kalampalika F, Ganuza M ( 2022 ) . Diversity in the bone marrow niche: Classic and novel strategies to uncover niche composition . British Journal of Haematology vol. 199 , ( 5 ) 647 - 664 .
Ganuza M, Clements W, McKinney-Freeman S ( 2021 ) . Specification of hematopoietic stem cells in mammalian embryos: a rare or frequent event? . Blood vol. 140 , ( 4 ) 309 - 320 .
Ganuza M, Hall T, Obeng EA, McKinney-Freeman S ( 2020 ) . Clones assemble! The clonal complexity of blood during ontogeny and disease . Experimental Hematology vol. 83 , 35 - 47 .
Ganuza M, Hall T, Finkelstein D, Wang Y-D, Chabot A, Kang G, Bi W, Wu G et al. ( 2019 ) . The global clonal complexity of the murine blood system declines throughout life and after serial transplantation . Blood vol. 133 , ( 18 ) 1927 - 1942 .
Ganuza M, Chabot A, Tang X, Bi W, Natarajan S, Carter R, Gawad C, Kang G et al. ( 2018 ) . Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs . Nature Communications vol. 9 , ( 1 ) 5405 - 5405 .
Hall T, Walker M, Ganuza M, Holmfeldt P, Bordas M, Kang G, Bi W, Palmer LE et al. ( 2018 ) . Nfix Promotes Survival of Immature Hematopoietic Cells via Regulation of c-Mpl . Stem Cells vol. 36 , ( 6 ) 943 - 950 .
Ganuza M, Hall T, Finkelstein D, Chabot A, Kang G, McKinney-Freeman S ( 2017 ) . Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny . Nature Cell Biology vol. 19 , ( 10 ) 1153 - 1163 .
Ganuza M, McKinney-Freeman S ( 2017 ) . Hematopoietic stem cells under pressure . Curr Opin Hematol vol. 24 , ( 4 ) 314 - 321 .
Ganuza M, Hadland B, Chabot A, Li C, Kang G, Bernstein I, McKinney-Freeman S ( 2017 ) . Murine hemogenic endothelial precursors display heterogeneous hematopoietic potential ex vivo . Experimental Hematology vol. 51 , 25 - 35.e6 .
Holmfeldt P, Ganuza M, Marathe H, He B, Hall T, Kang G, Moen J, Pardieck J et al. ( 2016 ) . Correction: Functional screen identifies regulators of murine hematopoietic stem cell repopulation . Journal of Experimental Medicine vol. 213 , ( 11 ) 2525 - 2525 .
Holmfeldt P, Ganuza M, Marathe H, He B, Hall T, Kang G, Moen J, Pardieck J et al. ( 2016 ) . Functional screen identifies regulators of murine hematopoietic stem cell repopulation . Journal of Experimental Medicine vol. 213 , ( 3 ) 433 - 449 .
Fernandez MG, Holmfeldt P, Marathe H, Hall T, Pardieck J, McKinney-Freeman S ( 2014 ) . Functional Screen Identifies Novel Regulators of Murine Hematopoietic Stem Cell Engraftment . Blood vol. 124 , ( 21 )
Ganuza M, Santamaría D ( 2012 ) . Cdk7: Open questions beyond the prevailing model . Cell Cycle vol. 11 , ( 19 ) 3519 - 3520 .
Ganuza M, Sáiz‐Ladera C, Cañamero M, Gómez G, Schneider R, Blasco MA, Pisano D, Paramio JM et al. ( 2012 ) . Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion . The EMBO Journal vol. 31 , ( 11 ) 2498 - 2510 .
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