Publications:  Dr Andrew Finch

Sirey TM, Roberts K, Haerty W, Bedoya-Reina O, Rogatti-Granados S, Tan JY, Li N, Heather LC et al.(2019). Erratum: Correction: The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity (eLife (2019) 8 PII: e50980). eLife vol. 8,

Pantazi A, Quintanilla A, Hari P, Tarrats N, Parasyraki E, Dix FL, Patel J, Chandra T et al.(2019). Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence. Aging Cell vol. 18, (4)

Hari P, Millar FR, Tarrats N, Birch J, Quintanilla A, Rink CJ, Fernández-Duran I, Muir M et al.(2019). The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Science Advances vol. 5, (6)

Sirey TM, Roberts K, Haerty W, Bedoya-Reina O, Granados SR, Tan JY, Li N, Heather LC et al.(2019). The long non-coding rna cerox1 is a post transcriptional regulator of mitochondrial complex i catalytic activity. eLife vol. 8,

Handley MT, Reddy K, Wills J, Rosser E, Kamath A, Halachev M, Falkous G, Williams D et al.(2019). ITPase deficiency causes a martsolf-like syndrome with a lethal infantile dilated cardiomyopathy. PLoS Genetics vol. 15, (3)

Guitart AV, Finch AJ, Kranc KR(2018). Ca²⁺tapulting HSCs into action. Journal of Experimental Medicine vol. 215, (8) 1971-1973.

Wills J, Edwards-Hicks J, Finch AJ(2017). AssayR: A Simple Mass Spectrometry Software Tool for Targeted Metabolic and Stable Isotope Tracer Analyses. Analytical Chemistry vol. 89, (18) 9616-9619.

Yeyati PL, Schiller R, Mali G, Kasioulis I, Kawamura A, Adams IR, Playfoot C, Gilbert N et al.(2017). KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability. Journal of Cell Biology vol. 216, (4) 999-1013.

Guitart AV, Panagopoulou TI, Villacreces A, Vukovic M, Sepulveda C, Allen L, Carter RN, van de Lagemaat LN et al.(2017). Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions. The Journal of experimental medicine vol. 214, (3) 719-735.

Meehan J, Ward C, Turnbull A, Bukowski-Wills J, Finch AJ, Jarman EJ, Xintaropoulou C, Martinez-Perez C et al.(2017). Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells. Oncotarget vol. 8, (26) 42857-42875.

Gammoh N, Fraser J, Puente C, Syred HM, Kang H, Ozawa T, Lam D, Acosta JC et al.(2016). Suppression of autophagy impedes glioblastoma development and induces senescence. Autophagy vol. 12, (9) 1431-1439.

Byrne KM, Monsefi N, Dawson JC, Degasperi A, Bukowski-Wills JC, Volinsky N, Dobrzy¿ski M, Birtwistle MR et al.(2016). Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches. Cell Systems vol. 2, (1) 38-48.

Rainger J, Pehlivan D, Johansson S, Bengani H, Sanchez-Pulido L, Williamson KA, Ture M, Barker H et al.(2014). Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations. American Journal of Human Genetics vol. 94, (6) 915-923.

Kasioulis I, Syred HM, Tate P, Finch A, Shaw J, Seawright A, Fuszard M, Botting CH et al.(2014). Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis. Molecular Biology of the Cell vol. 25, (8) 1216-1233.

Hilcenko C, Simpson PJ, Finch AJ, Bowler FR, Churcher MJ, Jin L, Packman LC, Shlien A et al.(2013). Aberrant 3′ oligoadenylation of spliceosomal U6 small nuclear RNA in poikiloderma with neutropenia. Blood vol. 121, (6) 1028-1038.

Lutzny G, Kocher T, Schmidt-Supprian M, Rudelius M, Klein-Hitpass L, Finch AJ, Dürig J, Wagner M et al.(2013). Protein Kinase C-β-Dependent Activation of NF-κB in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B Cells In Vivo. Cancer Cell vol. 23, (1) 77-92.

Finch AJ, Hilcenko C, Basse N, Drynan LF, Goyenechea B, Menne TF, Fernández AG, Simpson P et al.(2011). Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes shwachman-diamond syndrome. Genes and Development vol. 25, (9) 917-929.

Finch AJ, Soucek L, Junttila MR, Swigart LB, Evan GI(2009). Acute overexpression of Myc in intestinal epithelium recapitulates some but not all the changes elicited by Wnt/β-catenin pathway activation. Molecular and Cellular Biology vol. 29, (19) 5306-5315.

Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM, Karnezis AN, Swigart LB et al.(2008). Modelling Myc inhibition as a cancer therapy. Nature vol. 455, (7213) 679-683.

Cartlidge RA, Thomas GR, Cagnol S, Jong KA, Molton SA, Finch AJ, McMahon M(2008). Oncogenic BRAF^V600E inhibits BIM expression to promote melanoma cell survival. Pigment Cell and Melanoma Research vol. 21, (5) 534-544.

Ringshausen I, O'Shea CC, Finch AJ, Swigart LB, Evan GI(2006). Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell vol. 10, (6) 501-514.

Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI(2006). The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature vol. 443, (7108) 214-217.

Finch A, Prescott J, Shchors K, Hunt A, Soucek L, Dansen TB, Swigart L, Evan GI(2006). Bcl-x<inf>L</inf> gain of function and p19^ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms. Cancer Cell vol. 10, (2) 113-120.

Evan GI, Christophorou M, Lawlor EA, Ringshausen I, Prescott J, Dansen T, Finch A, Martins C et al. (2005). Oncogene-dependent tumor suppression: Using the dark side of the force for cancer therapy. Cold Spring Harbor Symposia on Quantitative Biology. vol. 70, 263-273.

Broaddus VC, Dansen TB, Abayasiriwardana KS, Wilson SM, Finch AJ, Swigart LB, Hunt AE, Evan GI(2005). Bid mediates apoptotic synergy between tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and DNA damage. Journal of Biological Chemistry vol. 280, (13) 12486-12493.

Finch A, Davis W, Carter WG, Saklatvala J(2001). Analysis of mitogen-activated protein kinase pathways used by interleukin 1 in tissues in vivo: Activation of hepatic c-Jun N-terminal kinases 1 and 2, and mitogen-activated protein kinase kinases 4 and 7. Biochemical Journal vol. 353, (2) 275-281.

Meier P, Finch A, Evan G(2000). Apoptosis in development. Nature vol. 407, (6805) 796-801.

Lasa M, Mahtani KR, Finch A, Brewer G, Saklatvala J, Clark AR(2000). Regulation of cyclooxygenase 2 mRNA stability by the mitogen- activated protein kinase p38 signaling cascade. Molecular and Cellular Biology vol. 20, (12) 4265-4274.

Saklatvala J, Dean J, Finch A(1999). Protein kinase cascades in intracellular signalling by interleukin-I and tumour necrosis factor. Biochemical Society Symposium vol. 64, 63-77.

Finch A, Holland P, Cooper J, Saklatvala J, Kracht M(1997). Selective activation of JNK/SAPK by interleukin-1 in rabbit liver is mediated by MKK7. FEBS Letters vol. 418, (1-2) 144-148.