Publications: Dr Andrew Finch

Dembitz V, Lawson H, Burt R, Natani S, Philippe C, James SC, Atkinson S, Durko J et al. ( 2024 ) . Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation . Leukemia vol. 38 , ( 11 ) 2395 - 2409 .

D’Avola A, Kluckova K, Finch AJ, Riches JC ( 2023 ) . Spotlight on New Therapeutic Opportunities for MYC-Driven Cancers . OncoTargets and Therapy vol. 16 , 371 - 383 .

Philippe C, Mian S, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D et al. ( 2023 ) . O20 TARGETING THE DEFECTIVE COA PATHWAY TO IMPROVE ERYTHROPOIESIS IN SF3B1-MUTANT MDS-RS PATIENTS . Leukemia Research vol. 128 ,

Lasa M, Mahtani KR, Finch A, Brewer G, Saklatvala J, Clark AR ( 2023 ) . Regulation of Cyclooxygenase 2 mRNA Stability by the Mitogen-Activated Protein Kinase p38 Signaling Cascade . Molecular and Cellular Biology vol. 20 , ( 12 ) 4265 - 4274 .

Finch AJ, Soucek L, Junttila MR, Swigart LB, Evan GI ( 2023 ) . Acute Overexpression of Myc in Intestinal Epithelium Recapitulates Some but Not All the Changes Elicited by Wnt/β-Catenin Pathway Activation . Molecular and Cellular Biology vol. 29 , ( 19 ) 5306 - 5315 .

Mian SA, Philippe C, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D et al. ( 2023 ) . Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia . Science Translational Medicine vol. 15 , ( 685 ) eabn5135 - eabn5135 .

Dembitz V, Lawson H, Philippe C, Burt RJ, James S, Magee ASM, Woodley K, Durko J et al. ( 2022 ) . Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid Leukemia . Blood vol. 140 , ( Supplement 1 ) 3058 - 3060 .

Altea-Manzano P, Vandekeere A, Edwards-Hicks J, Roldan M, Abraham E, Lleshi X, Guerrieri AN, Berardi D et al. ( 2022 ) . Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells . Molecular Cell vol. 82 , ( 23 ) 4537 - 4547.e7 .

Aird R, Wills J, Roby KF, Bénézech C, Stimson RH, Wabitsch M, Pollard JW, Finch A et al. ( 2022 ) . Hypoxia-driven metabolic reprogramming of adipocytes fuels cancer cell proliferation . Frontiers in Endocrinology vol. 13 ,

Edwards-Hicks J, Su H, Mangolini M, Yoneten KK, Wills J, Rodriguez-Blanco G, Young C, Cho K et al. ( 2022 ) . MYC sensitises cells to apoptosis by driving energetic demand . Nature Communications vol. 13 , ( 1 )

Carter RN, Gibbins MTG, Barrios-Llerena ME, Wilkie SE, Freddolino PL, Libiad M, Vitvitsky V, Emerson B et al. ( 2021 ) . The hepatic compensatory response to elevated systemic sulfide promotes diabetes . Cell Reports vol. 37 , ( 6 )

Mian S, Philippe C, Maniati E, Bergot T, Piganeau M, Di Bella D, Morales V, Finch A et al. ( 2021 ) . Vitamin B5 and Succinyl-CoA Improve Ineffective Erythropoiesis in SF3B1 Mutated Myelodysplasia . Blood vol. 138 , ( Supplement 1 )

Symeonidou V, Jakobczyk H, Bashanfer S, Malouf C, Fotopoulou F, Kotecha RS, Anderson RA, Finch AJ et al. ( 2021 ) . Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements . Cell Reports vol. 37 , ( 4 )

Finch AJ, Baena E ( 2021 ) . Spatiofunctional Dynamics of NKX3.1 to Safeguard the Prostate from Cancer . Cancer Discovery vol. 11 , ( 9 ) 2132 - 2134 .

Watts ER, Howden AJM, Morrison T, Sadiku P, Hukelmann JL, von Kriegsheim A, Ghesquière B, Murphy F et al. ( 2021 ) . Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism . Journal of Clinical Investigation vol. 131 , ( 10 )

Hajeyah AA, Griffiths WJ, Wang Y, Finch AJ, O’Donnell VB ( 2020 ) . The Biosynthesis of Enzymatically Oxidized Lipids . Frontiers in Endocrinology vol. 11 , 591819 - 591819 .

Sirey TM, Roberts K, Haerty W, Bedoya-Reina O, Rogatti-Granados S, Tan JY, Li N, Heather LC et al. ( 2019 ) . Correction: The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity . eLife vol. 8 ,

Masalmeh RHA, Rubio-Ramon C, Taglini F, Higham J, Davidson-Smith H, Clark R, Wills J, Finch AJ et al. ( 2019 ) . De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands .

Hari P, Millar FR, Tarrats N, Birch J, Quintanilla A, Rink CJ, Fernández-Duran I, Muir M et al. ( 2019 ) . The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype . Science Advances vol. 5 , ( 6 )

Pantazi A, Quintanilla A, Hari P, Tarrats N, Parasyraki E, Dix FL, Patel J, Chandra T et al. ( 2019 ) . Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence . Aging Cell vol. 18 , ( 4 )

Sirey TM, Roberts K, Haerty W, Bedoya-Reina O, Rogatti-Granados S, Tan JY, Li N, Heather LC et al. ( 2019 ) . The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity . eLife vol. 8 ,

Handley MT, Reddy K, Wills J, Rosser E, Kamath A, Halachev M, Falkous G, Williams D et al. ( 2019 ) . ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy . PLOS Genetics vol. 15 , ( 3 )

Pantazi A, Quintanilla A, Hari P, Tarrats N, Parasyraki E, Dix FL, Patel J, Chandra T et al. ( 2018 ) . Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence .

Guitart AV, Finch AJ, Kranc KR ( 2018 ) . Ca2+tapulting HSCs into action . Journal of Experimental Medicine vol. 215 , ( 8 ) 1971 - 1973 .

Wills J, Edwards-Hicks J, Finch AJ ( 2017 ) . AssayR: A Simple Mass Spectrometry Software Tool for Targeted Metabolic and Stable Isotope Tracer Analyses . Analytical Chemistry vol. 89 , ( 18 ) 9616 - 9619 .

Meehan J, Ward C, Turnbull A, Bukowski-Wills J, Finch AJ, Jarman EJ, Xintaropoulou C, Martinez-Perez C et al. ( 2017 ) . Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells . Oncotarget vol. 5 , ( 0 ) 42857 - 42875 .

Yeyati PL, Schiller R, Mali G, Kasioulis I, Kawamura A, Adams IR, Playfoot C, Gilbert N et al. ( 2017 ) . KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability . Journal of Cell Biology vol. 216 , ( 4 ) 999 - 1013 .

Guitart AV, Panagopoulou TI, Villacreces A, Vukovic M, Sepulveda C, Allen L, Carter RN, van de Lagemaat LN et al. ( 2017 ) . Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions . Journal of Experimental Medicine vol. 214 , ( 3 ) 719 - 735 .

Gammoh N, Fraser J, Puente C, Syred HM, Kang H, Ozawa T, Lam D, Acosta JC et al. ( 2016 ) . Suppression of autophagy impedes glioblastoma development and induces senescence . Autophagy vol. 12 , ( 9 ) 1431 - 1439 .

Byrne KM, Monsefi N, Dawson JC, Degasperi A, Bukowski-Wills J-C, Volinsky N, Dobrzyński M, Birtwistle MR et al. ( 2016 ) . Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches . Cell Systems vol. 2 , ( 1 ) 38 - 48 .

Guitart AV, Vukovic M, Sas Z, Vila M, Sepulveda C, Panagopoulou T, Allen L, Pollard P et al. ( 2015 ) . FUMARATE HYDRATASE IS AN ESSENTIAL REGULATOR OF EMBRYONIC AND ADULT HAEMATOPOIETIC STEM CELL . HAEMATOLOGICA . vol. 100 , 123 - 123 .

Rainger J, Pehlivan D, Johansson S, Bengani H, Sanchez-Pulido L, Williamson KA, Ture M, Barker H et al. ( 2014 ) . Monoallelic and Biallelic Mutations in MAB21L2 Cause a Spectrum of Major Eye Malformations . American Journal of Human Genetics vol. 94 , ( 6 ) 915 - 923 .

Kasioulis I, Syred HM, Tate P, Finch A, Shaw J, Seawright A, Fuszard M, Botting CH et al. ( 2014 ) . Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis . Molecular Biology of the Cell vol. 25 , ( 8 ) 1216 - 1233 .

Lutzny G, Kocher T, Schmidt-Supprian M, Rudelius M, Klein-Hitpass L, Finch AJ, Dürig J, Wagner M et al. ( 2013 ) . Protein Kinase C-β-Dependent Activation of NF-κB in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B Cells In Vivo . Cancer Cell vol. 23 , ( 1 ) 77 - 92 .

Hilcenko C, Simpson PJ, Finch AJ, Bowler FR, Churcher MJ, Jin L, Packman LC, Shlien A et al. ( 2012 ) . Aberrant 3′ oligoadenylation of spliceosomal U6 small nuclear RNA in poikiloderma with neutropenia . Blood vol. 121 , ( 6 ) 1028 - 1038 .

Finch AJ, Hilcenko C, Basse N, Drynan LF, Goyenechea B, Menne TF, Fernández ÁG, Simpson P et al. ( 2011 ) . Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome . Genes & Development vol. 25 , ( 9 ) 917 - 929 .

Cartlidge RA, Thomas GR, Cagnol S, Jong KA, Molton SA, Finch AJ, McMahon M ( 2008 ) . Oncogenic BRAFV600E inhibits BIM expression to promote melanoma cell survival . Pigment Cell & Melanoma Research vol. 21 , ( 5 ) 534 - 544 .

Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM, Karnezis AN, Swigart LB et al. ( 2008 ) . Modelling Myc inhibition as a cancer therapy . Nature vol. 455 , ( 7213 ) 679 - 683 .

Ringshausen I, O'Shea CC, Finch AJ, Swigart LB, Evan GI ( 2006 ) . Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo . Cancer Cell vol. 10 , ( 6 ) 501 - 514 .

Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI ( 2006 ) . The pathological response to DNA damage does not contribute to p53-mediated tumour suppression . Nature vol. 443 , ( 7108 ) 214 - 217 .

Finch A, Prescott J, Shchors K, Hunt A, Soucek L, Dansen TB, Swigart LB, Evan GI ( 2006 ) . Bcl-xL gain of function and p19ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms . Cancer Cell vol. 10 , ( 2 ) 113 - 120 .

Evan GI, Christophorou M, Lawlor EA, Ringshausen I, Prescott J, Dansen T, Finch A, Martins C et al. ( 2005 ) . Oncogene-dependent Tumor Suppression: Using the Dark Side of the Force for Cancer Therapy . Cold Spring Harbor Symposia on Quantitative Biology . vol. 70 , 263 - 273 .

Broaddus VC, Dansen TB, Abayasiriwardana KS, Wilson SM, Finch AJ, Swigart LB, Hunt AE, Evan GI ( 2004 ) . Bid Mediates Apoptotic Synergy between Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) and DNA Damage* . Journal of Biological Chemistry vol. 280 , ( 13 ) 12486 - 12493 .

Finch A, Davis W, Carter WG, Saklatvala J ( 2001 ) . Analysis of mitogen-activated protein kinase pathways used by interleukin 1 in tissues in vivo: activation of hepatic c-Jun N-terminal kinases 1 and 2, and mitogen-activated protein kinase kinases 4 and 7 . Biochemical Journal vol. 353 , ( Pt 2 ) 275 - 281 .

Meier P, Finch A, Evan G ( 2000 ) . Apoptosis in development . Nature vol. 407 , ( 6805 ) 796 - 801 .

Saklatvala J, Dean J, Finch A ( 1999 ) . Protein kinase cascades in intracellular signalling by interleukin-I and tumour necrosis factor . Biochemical Society Symposia vol. 64 , 63 - 77 .

Finch A, Holland P, Cooper J, Saklatvala J, Kracht M ( 1997 ) . Selective activation of JNK/SAPK by interleukin‐1 in rabbit liver is mediated by MKK7 . FEBS Letters vol. 418 , ( 1-2 ) 144 - 148 .