Publications: Prof Qingbo Xu

Sun X, Wu J, Zhang X, Xie C, Wei H, Li P, Yang Y, Yuan H et al. ( 2024 ) . Atlas of Cell Repertoire Within Neointimal Lesions Is Metabolically Altered in Hypertensive Rats . Hypertension

Cerrato G, Alvarez-Lucena C, Sauvat A, Hu Y, Forveille S, Chen G, Durand S, Aprahamian F et al. ( 2023 ) . 3,4-dimethoxychalcone induces autophagy and reduces neointimal hyperplasia and aortic lesions in mouse models of atherosclerosis . Cell Death & Disease vol. 14 , ( 11 )

Li X, Pan Y, Liu K, Yang Y, Ye Y, Xu Q, Fan M, Guo F ( 2023 ) . Identification and functional coordination analysis of gene co-expression networks in different tissues of XBP1 cartilage-specific deficient mice . Cellular Signalling vol. 113 ,

Tao T, Du L, Teng P, Guo Y, Wang X, Hu Y, Zhao H, Xu Q et al. ( 2023 ) . Stem cell antigen-1+cell-derived fibroblasts are crucial for cardiac fibrosis during heart failure . Cellular and Molecular Life Sciences vol. 80 , ( 10 )

Ma Y, Han C, Xie C, Dang Q, Yang L, Li Y, Zhang M, Cheng J et al. ( 2023 ) . ATP promotes resident CD34+ cell migration mainly through P2Y2-Stim1-ERK/p38 pathway . American Journal of Physiology - Cell Physiology vol. 325 , ( 5 ) c1228 - c1243 .

Lu Y, Leng Y, Li Y, Wang J, Wang W, Wang R, Liu Y, Tan Q et al. ( 2023 ) . Endothelial RIPK1 protects artery bypass graft against arteriosclerosis by regulating SMC growth . Science Advances vol. 9 , ( 35 )

Chen T, Sun X, Gong H, Chen M, Li Y, Zhang Y, Wang T, Huang X et al. ( 2023 ) . Host CD34+ cells are replacing donor endothelium of transplanted heart . The Journal of Heart and Lung Transplantation vol. 42 , ( 12 ) 1651 - 1665 .

Sun X, Lu Y, Wu J, Wen Q, Li Z, Tang Y, Shi Y, He T et al. ( 2023 ) . Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease . Arteriosclerosis Thrombosis and Vascular Biology vol. 43 , ( 10 ) 1867 - 1886 .

Cheng J, Wu H, Xie C, He Y, Mou R, Zhang H, Yang Y, Xu Q ( 2023 ) . Single-Cell Mapping of Large and Small Arteries During Hypertensive Aging . The Journals of Gerontology Series A vol. 79 , ( 2 )

Cui Y, Li C, Zeng X, Wei X, Li P, Cheng J, Xu Q, Yang Y ( 2023 ) . Correction: ATP purinergic receptor signalling promotes Sca-1 + cell proliferation and migration for vascular remodelling . Cell Communication and Signaling vol. 21 , ( 1 )

Cui Y, Li C, Zeng X, Wei X, Li P, Cheng J, Xu Q, Yang Y ( 2023 ) . ATP purinergic receptor signalling promotes Sca-1+ cell proliferation and migration for vascular remodelling . Cell Communication and Signaling vol. 21 , ( 1 )

Lu Y, Kiechl SJ, Wang J, Xu Q, Kiechl S, Pechlaner R, Aguilar D, Al-Hashmi KM et al. ( 2023 ) . Global distributions of age- and sex-related arterial stiffness: systematic review and meta-analysis of 167 studies with 509,743 participants . eBioMedicine . vol. 92 ,

Xie J, Jiang L, Wang J, Yin Y, Wang R, Du L, Chen T, Ni Z et al. ( 2023 ) . Multilineage contribution of CD34+ cells in cardiac remodeling after ischemia/reperfusion injury . Basic Research in Cardiology vol. 118 , ( 1 )

Song Y, Yang J, Li T, Sun X, Lin R, He Y, Sun K, Han J et al. ( 2023 ) . CD34+ cell–derived fibroblast-macrophage cross-talk drives limb ischemia recovery through the OSM-ANGPTL signaling axis . Science Advances vol. 9 , ( 15 )

Ni Z, Lyu L, Gong H, Du L, Wen Z, Jiang H, Yang H, Hu Y et al. ( 2023 ) . Multilineage commitment of Sca-1+ cells in reshaping vein grafts . Theranostics vol. 13 , ( 7 ) 2154 - 2175 .

Gorospe M, Liu Y, Xu Q, Chrest FJ, Holbrook NJ ( 2023 ) . Inhibition of G1 Cyclin-Dependent Kinase Activity during Growth Arrest of Human Breast Carcinoma Cells by Prostaglandin A2 . Molecular and Cellular Biology vol. 16 , ( 3 ) 762 - 770 .

Du L, Sun X, Gong H, Wang T, Jiang L, Huang C, Xu X, Li Z et al. ( 2023 ) . Single cell and lineage tracing studies reveal the impact of CD34+ cells on myocardial fibrosis during heart failure . Stem Cell Research & Therapy vol. 14 , ( 1 )

Wu H, Xie C, Wang R, Cheng J, Xu Q, Zhao H ( 2023 ) . Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level . Frontiers in Pharmacology vol. 13 ,

Ma Z, Mao C, Chen X, Yang S, Qiu Z, Yu B, Jia Y, Wu C et al. ( 2022 ) . Peptide Vaccine Against ADAMTS-7 Ameliorates Atherosclerosis and Postinjury Neointima Hyperplasia . Circulation vol. 147 , ( 9 ) 728 - 742 .

Mou R, Chen K, Zhu P, Xu Q, Ma L ( 2022 ) . The Impact of Stem/Progenitor Cells on Lymphangiogenesis in Vascular Disease . Cells vol. 11 , ( 24 )

Chen K, Mou R, Zhu P, Xu X, Wang H, Jiang L, Hu Y, Hu X et al. ( 2022 ) . The Effect of Lymphangiogenesis in Transplant Arteriosclerosis . Circulation vol. 147 , ( 6 ) 482 - 497 .

Lin S, Lin R, Zhang H, Xu Q, He Y ( 2022 ) . Peripheral vascular remodeling during ischemia . Frontiers in Pharmacology vol. 13 ,

Pu X, Zhu P, Zhou X, He Y, Wu H, Du L, Gong H, Sun X et al. ( 2022 ) . CD34+ cell atlas of main organs implicates its impact on fibrosis . Cellular and Molecular Life Sciences vol. 79 , ( 11 )

Jia Y, Mao C, Ma Z, Huang J, Li W, Ma X, Zhang S, Li M et al. ( 2022 ) . PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting PKM2 Splicing . Circulation Research vol. 131 , ( 10 ) 807 - 824 .

Wang F, Qin K, Wang K, Wang H, Liu Q, Qian M, Chen S, Sun Y et al. ( 2022 ) . Nitric oxide improves regeneration and prevents calcification in bio-hybrid vascular grafts via regulation of vascular stem/progenitor cells . Cell Reports vol. 39 , ( 12 )

Jia Y, Zhang L, Liu Z, Mao C, Ma Z, Li W, Yu F, Wang Y et al. ( 2022 ) . Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm . Cell Discovery vol. 8 , ( 1 )

Ma X, Deng J, Han L, Song Y, Miao Y, Du X, Dang G, Yang D et al. ( 2022 ) . Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis . Protein & Cell vol. 13 , ( 7 ) 540 - 547 .

Li X, Yang Y, Liang L, Fan M, Li X, Feng N, Pan Y, Tan Q et al. ( 2022 ) . Effect Of XBP1 Deficiency In Cartilage On The Regulatory Network Of LncRNA/circRNA-miRNA-mRNA . International Journal of Biological Sciences vol. 18 , ( 1 ) 315 - 330 .

Han L, Miao Y, Zhao Y, Zhang X, Ma X, Du X, Kong W, Xu Q et al. ( 2021 ) . The binding of autotaxin to integrins mediates hyperhomocysteinemia-potentiated platelet activation and thrombosis in mice and humans . Blood Advances vol. 6 , ( 1 ) 46 - 61 .

Zhang X-J, Ji Y-X, Cheng X, Cheng Y, Yang H, Wang J, Zhao L-P, Huang Y-P et al. ( 2021 ) . A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques . Science Translational Medicine vol. 13 , ( 624 )

Zhang X-J, She Z-G, Wang J, Sun D, Shen L-J, Xiang H, Cheng X, Ji Y-X et al. ( 2021 ) . Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis . Science Translational Medicine vol. 13 , ( 624 )

Yang L, Dai R, Wu H, Cai Z, Xie N, Zhang X, Shen Y, Gong Z et al. ( 2021 ) . Unspliced XBP1 Counteracts β-Catenin to Inhibit Vascular Calcification . Circulation Research vol. 130 , ( 2 ) 213 - 229 .

Wang X, Wang R, Jiang L, Xu Q, Guo X ( 2021 ) . Endothelial repair by stem and progenitor cells . Journal of Molecular and Cellular Cardiology vol. 163 , 133 - 146 .

Gong H, Wang T, Xu Q ( 2021 ) . Resident stem cells in the heart . Medical Review vol. 1 , ( 1 ) 10 - 13 .

Zhang X-J, Liu X, Hu M, Zhao G-J, Sun D, Cheng X, Xiang H, Huang Y-P et al. ( 2021 ) . Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species . Cell Metabolism vol. 33 , ( 10 ) 2059 - 2075.e10 .

Jiang L, Chen T, Sun S, Wang R, Deng J, Lyu L, Wu H, Yang M et al. ( 2021 ) . Nonbone Marrow CD34+ Cells Are Crucial for Endothelial Repair of Injured Artery . Circulation Research vol. 129 , ( 8 ) e146 - e165 .

Wang X, Zhu X-X, Jiao S-Y, Qi D, Yu B-Q, Xie G-M, Liu Y, Song Y-T et al. ( 2021 ) . Cardiomyocyte peroxisome proliferator-activated receptor α is essential for energy metabolism and extracellular matrix homeostasis during pressure overload-induced cardiac remodeling . Acta Pharmacologica Sinica vol. 43 , ( 5 ) 1231 - 1242 .

Duan Y, Qi D, Liu Y, Song Y, Wang X, Jiao S, Li H, Gonzalez FJ et al. ( 2021 ) . Deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells . Biochemistry and Biophysics Reports vol. 27 ,

Sun X, Lyu L, Zhong X, Ni Z, Xu Q ( 2021 ) . Application of genetic cell-lineage tracing technology to study cardiovascular diseases . Journal of Molecular and Cellular Cardiology vol. 156 , 57 - 68 .

Wu H, Zhou X, Gong H, Ni Z, Xu Q ( 2021 ) . Perivascular tissue stem cells are crucial players in vascular disease . Free Radical Biology and Medicine vol. 165 , 324 - 333 .

Fu Y, Huang Y, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z et al. ( 2021 ) . Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury . Cell Research vol. 31 , ( 7 ) 773 - 790 .

Jiang L, Sun X, Deng J, Hu Y, Xu Q ( 2021 ) . Different Roles of Stem/Progenitor Cells in Vascular Remodeling . Antioxidants & Redox Signaling vol. 35 , ( 3 ) 192 - 203 .

Lu Y, Wu J, Gu W, Huang Z, Shu Z, Huang M, Chen J, Zhou M et al. ( 2021 ) . Single-cell transcriptomics uncovers phenotypic alterations in the monocytes in a Chinese population with chronic cadmium exposure . Ecotoxicology and Environmental Safety vol. 211 ,

Liu H, Chen J, Yang Q, Lei F, Zhang C, Qin J-J, Chen Z, Zhu L et al. ( 2021 ) . Development and validation of a risk score using complete blood count to predict in-hospital mortality in COVID-19 patients . Med vol. 2 , ( 4 ) 435 - 447.e4 .

Cai J, Li H, Zhang C, Chen Z, Liu H, Lei F, Qin J-J, Liu Y-M et al. ( 2021 ) . The Neutrophil-to-Lymphocyte Ratio Determines Clinical Efficacy of Corticosteroid Therapy in Patients with COVID-19 . Cell Metabolism vol. 33 , ( 2 ) 258 - 269.e3 .

Zhou Y, Huang C, Hu Y, Xu Q, Hu X ( 2020 ) . Lymphatics in Cardiovascular Disease . Arteriosclerosis Thrombosis and Vascular Biology vol. 40 , ( 11 ) e275 - e283 .

Pu X, Du L, Hu Y, Fan Y, Xu Q ( 2020 ) . Stem/Progenitor Cells and Pulmonary Arterial Hypertension . Arteriosclerosis Thrombosis and Vascular Biology vol. 41 , ( 1 ) 167 - 178 .

Cheng X, Liu Y-M, Li H, Zhang X, Lei F, Qin J-J, Chen Z, Deng K-Q et al. ( 2020 ) . Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes . Cell Metabolism vol. 32 , ( 4 ) 537 - 547.e3 .

Miao Y, Zhao Y, Han L, Ma X, Deng J, Yang J, Lü S, Shao F et al. ( 2020 ) . NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment . Cellular and Molecular Life Sciences vol. 78 , ( 4 ) 1709 - 1727 .

Cai J, Deng J, Gu W, Ni Z, Liu Y, Kamra Y, Saxena A, Hu Y et al. ( 2020 ) . Impact of Local Allo-Immunity and Recipient Cells in Transplant Arteriosclerosis . Circulation Research

Qin K, Wang F, Simpson RML, Zheng X, Wang H, Hu Y, Gao Z, Xu Q et al. ( 2020 ) . Hyaluronan promotes the regeneration of vascular smooth muscle with potent contractile function in rapidly biodegradable vascular grafts . Biomaterials vol. 257 ,

Qin J-J, Cheng X, Zhou F, Lei F, Akolkar G, Cai J, Zhang X-J, Blet A et al. ( 2020 ) . Redefining cardiac biomarkers in predicting mortality of inpatients with COVID-19 . Hypertension vol. 76 , ( 4 ) 1104 - 1112 .

Chen D, Li K, Festenstein S, Karegli J, Wilkinson H, Leonard H, Wei L, Ma N et al. ( 2020 ) . Regression of Atherosclerosis in ApoE−/− Mice Via Modulation of Monocyte Recruitment and Phenotype, Induced by Weekly Dosing of a Novel “Cytotopic” Anti‐Thrombin Without Prolonged Anticoagulation . Journal of the American Heart Association vol. 9 , ( 13 )

Pechlaner R, Xu Q, Kiechl S ( 2020 ) . Reply Vascular Age Is Not Only Atherosclerosis, it Is Also Arteriosclerosis . Journal of the American College of Cardiology vol. 76 , ( 2 ) 230 - 231 .

Cheng J, Gu W, Lan T, Deng J, Ni Z, Zhang Z, Hu Y, Sun X et al. ( 2020 ) . Single-cell RNA sequencing reveals cell type- and artery type-specific vascular remodelling in male spontaneously hypertensive rats . Cardiovascular Research vol. 117 , ( 4 ) 1202 - 1216 .

Zhang X-J, Qin J-J, Cheng X, Shen L, Zhao Y-C, Yuan Y, Lei F, Chen M-M et al. ( 2020 ) . In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19 . Cell Metabolism vol. 32 , ( 2 ) 176 - 187.e4 .

Zhou F, Liu Y-M, Xie J, Li H, Lei F, Yang H, Qin J-J, Cai J et al. ( 2020 ) . Comparative Impacts of ACE (Angiotensin-Converting Enzyme) Inhibitors Versus Angiotensin II Receptor Blockers on the Risk of COVID-19 Mortality . Hypertension vol. 76 , ( 2 ) e15 - e17 .

Zhang P, Zhu L, Cai J, Lei F, Qin J-J, Xie J, Liu Y-M, Zhao Y-C et al. ( 2020 ) . Association of Inpatient Use of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers with Mortality Among Patients With Hypertension Hospitalized With COVID-19 . Circulation Research vol. 126 , ( 12 ) 1671 - 1681 .

Deng J, Ni Z, Gu W, Chen Q, Nowak WN, Chen T, Issa Bhaloo S, Zhang Z et al. ( 2020 ) . Single-cell gene profiling and lineage tracing analyses revealed novel mechanisms of endothelial repair by progenitors . Cellular and Molecular Life Sciences vol. 77 , ( 24 ) 5299 - 5320 .

Song Y, Qi D, Wang X, Liu Y, Xie G, Yu B, Xu Q, Gonzalez FJ et al. ( 2020 ) . Hypoxia inducible factor 2α inhibition in vascular smooth muscle cells (VSMCs) abolishes abdominal aortic aneurysm in ApoE−/− mice . Journal of Molecular and Cellular Cardiology vol. 140 ,

Lu Y, Pechlaner R, Cai J, Yuan H, Huang Z, Yang G, Wang J, Chen Z et al. ( 2020 ) . Trajectories of Age-Related Arterial Stiffness in Chinese Men and Women . Journal of the American College of Cardiology vol. 75 , ( 8 ) 870 - 880 .

Shao F, Miao Y, Zhang Y, Han L, Ma X, Deng J, Jiang C, Kong W et al. ( 2019 ) . B cell-derived anti-beta 2 glycoprotein I antibody contributes to hyperhomocysteinaemia-aggravated abdominal aortic aneurysm . Cardiovascular Research vol. 116 , ( 11 ) 1897 - 1909 .

Kelleher J, Dickinson A, Cain S, Hu Y, Bates N, Harvey A, Ren J, Zhang W et al. ( 2019 ) . Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures . Stem Cell Reports vol. 13 , ( 5 ) 817 - 831 .

Lü S-L, Dang G-H, Deng J-C, Liu H-Y, Liu B, Yang J, Ma X-L, Miao Y-T et al. ( 2019 ) . Shikonin attenuates hyperhomocysteinemia-induced CD4+ T cell inflammatory activation and atherosclerosis in ApoE−/− mice by metabolic suppression . Acta Pharmacologica Sinica vol. 41 , ( 1 ) 47 - 55 .

Yang J, Dang G, Lü S, Liu H, Ma X, Han L, Deng J, Miao Y et al. ( 2019 ) . T‐cell–derived extracellular vesicles regulate B‐cell IgG production via pyruvate kinase muscle isozyme 2 . The FASEB Journal vol. 33 , ( 11 ) 12780 - 12799 .

Gu W, Nowak WN, Xie Y, Le Bras A, Hu Y, Deng J, Bhaloo SI, Lu Y et al. ( 2019 ) . Single-Cell RNA-Sequencing and Metabolomics Analyses Reveal the Contribution of Perivascular Adipose Tissue Stem Cells to Vascular Remodeling . Arteriosclerosis Thrombosis and Vascular Biology vol. 39 , ( 10 ) 2049 - 2066 .

Qi D, Wei M, Jiao S, Song Y, Wang X, Xie G, Taranto J, Liu Y et al. ( 2019 ) . Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment . Cell Death & Disease vol. 10 , ( 8 )

JIANG L, XU Q ( 2019 ) . Current status and prospects of cardiovascular stem/progenitor cells in cardiovascular regenerative medicine . Scientia Sinica Vitae vol. 49 , ( 8 ) 965 - 976 .

Ni Z, Deng J, Potter CMF, Nowak WN, Gu W, Zhang Z, Chen T, Chen Q et al. ( 2019 ) . Recipient c-Kit Lineage Cells Repopulate Smooth Muscle Cells of Transplant Arteriosclerosis in Mouse Models . Circulation Research vol. 125 , ( 2 ) 223 - 241 .

Cheng J, Wen J, Wang N, Wang C, Xu Q, Yang Y ( 2019 ) . Ion Channels and Vascular Diseases . Arteriosclerosis Thrombosis and Vascular Biology vol. 39 , ( 5 ) e146 - e156 .

Gu W, Ni Z, Tan Y-Q, Deng J, Zhang S-J, Lv Z-C, Wang X-J, Chen T et al. ( 2019 ) . Adventitial Cell Atlas of wt (Wild Type) and ApoE (Apolipoprotein E)-Deficient Mice Defined by Single-Cell RNA Sequencing . Arteriosclerosis Thrombosis and Vascular Biology vol. 39 , ( 6 ) 1055 - 1071 .

Ludwinski FE, Patel AS, Damodaran G, Cho J, Furmston J, Xu Q, Jayasinghe SN, Smith A et al. ( 2019 ) . Encapsulation of macrophages enhances their retention and angiogenic potential . npj Regenerative Medicine vol. 4 , ( 1 )

Fan Y, Chen Y, Zhang J, Yang F, Hu Y, Zhang L, Zeng C, Xu Q ( 2019 ) . Protective Role of RNA Helicase DEAD-Box Protein 5 in Smooth Muscle Cell Proliferation and Vascular Remodeling . Circulation Research vol. 124 , ( 10 ) e84 - e100 .

Chen T, Karamariti E, Hong X, Deng J, Wu Y, Gu W, Simpson R, Wong MM et al. ( 2019 ) . DKK3 (Dikkopf-3) Transdifferentiates Fibroblasts Into Functional Endothelial Cells—Brief Report . Arteriosclerosis Thrombosis and Vascular Biology vol. 39 , ( 4 ) 765 - 773 .

Lu Y, Thavarajah T, Gu W, Cai J, Xu Q ( 2018 ) . Impact of miRNA in Atherosclerosis . Arteriosclerosis Thrombosis and Vascular Biology vol. 38 , ( 9 ) e159 - e170 .

Li Y, He L, Huang X, Bhaloo SI, Zhao H, Zhang S, Pu W, Tian X et al. ( 2018 ) . Genetic Lineage Tracing of Nonmyocyte Population by Dual Recombinases . Circulation vol. 138 , ( 8 ) 793 - 805 .

Chen Q, Yang M, Wu H, Zhou J, Wang W, Zhang H, Zhao L, Zhu J et al. ( 2018 ) . Genetic lineage tracing analysis of c-kit+ stem/progenitor cells revealed a contribution to vascular injury-induced neointimal lesions . Journal of Molecular and Cellular Cardiology vol. 121 , 277 - 286 .

Ma B, Yao F, Xie N, Mao C, Liu F, Gong Z, Zhao G, Liu Z et al. ( 2018 ) . Cartilage oligomeric matrix protein is a novel notch ligand driving embryonic stem cell differentiation towards the smooth muscle lineage . Journal of Molecular and Cellular Cardiology vol. 121 , 69 - 80 .

Chen T, Wu Y, Gu W, Xu Q ( 2018 ) . Response of vascular mesenchymal stem/progenitor cells to hyperlipidemia . Cellular and Molecular Life Sciences vol. 75 , ( 22 ) 4079 - 4091 .

Pan Y, Yang J, Wei Y, Wang H, Jiao R, Moraga A, Zhang Z, Hu Y et al. ( 2018 ) . Histone Deacetylase 7‐Derived Peptides Play a Vital Role in Vascular Repair and Regeneration . Advanced Science vol. 5 , ( 8 )

Bhaloo SI, Wu Y, Le Bras A, Yu B, Gu W, Xie Y, Deng J, Wang Z et al. ( 2018 ) . Binding of Dickkopf-3 to CXCR7 Enhances Vascular Progenitor Cell Migration and Degradable Graft Regeneration . Circulation Research vol. 123 , ( 4 ) 451 - 466 .

Jia Y, Wang M, Mao C, Yu F, Wang Y, Xiao R, Jiang C, Zheng L et al. ( 2018 ) . COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity . Cell Death & Disease vol. 9 , ( 6 )

Zhang L, Bhaloo SI, Chen T, Zhou B, Xu Q ( 2018 ) . Role of Resident Stem Cells in Vessel Formation and Arteriosclerosis . Circulation Research vol. 122 , ( 11 ) 1608 - 1624 .

Lü S, Deng J, Liu H, Liu B, Yang J, Miao Y, Li J, Wang N et al. ( 2018 ) . PKM2-dependent metabolic reprogramming in CD4+ T cells is crucial for hyperhomocysteinemia-accelerated atherosclerosis . Journal of Molecular Medicine vol. 96 , ( 6 ) 585 - 600 .

Issa Bhaloo S, Wu Y, Le Bras A, Hu Y, Xu Q, Zhao Q ( 2018 ) . Abstract 479: Dickkopf-3 Binds to CXCR7 of Vascular Progenitor Cells to Enhance Degradable Graft Regeneration . Arteriosclerosis Thrombosis and Vascular Biology vol. 38 , ( Suppl_1 )

Gu W, Hong X, Le Bras A, Xu Q, Hu Y ( 2018 ) . Abstract 650: Stem Cell-derived SMCs Are Useful for Vascular Tissue Engineering . Arteriosclerosis Thrombosis and Vascular Biology vol. 38 , ( Suppl_1 )

Li J, Zhang Y, Zhang Y, Lü S, Miao Y, Yang J, Huang S, Ma X et al. ( 2018 ) . GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation . Redox Biology vol. 17 , 386 - 399 .

Gu W, Hong X, Le Bras A, Nowak WN, Bhaloo SI, Deng J, Xie Y, Hu Y et al. ( 2018 ) . Smooth muscle cells differentiated from mesenchymal stem cells are regulated by microRNAs and suitable for vascular tissue grafts . Journal of Biological Chemistry vol. 293 , ( 21 ) 8089 - 8102 .

Liu Y, Wang Z, Li J, Ban Y, Mao G, Zhang M, Wang M, Liu Y et al. ( 2018 ) . Inhibition of 5‐Hydroxytryptamine Receptor 2B Reduced Vascular Restenosis and Mitigated the β‐Arrestin2–Mammalian Target of Rapamycin/p70S6K Pathway . Journal of the American Heart Association vol. 7 , ( 3 )

Karamariti E, Zhai C, Yu B, Qiao L, Wang Z, Potter CMF, Wong MM, Simpson RML et al. ( 2017 ) . DKK3 (Dickkopf 3) Alters Atherosclerotic Plaque Phenotype Involving Vascular Progenitor and Fibroblast Differentiation Into Smooth Muscle Cells . Arteriosclerosis Thrombosis and Vascular Biology vol. 38 , ( 2 ) 425 - 437 .

Zhai C-G, Xu Y-Y, Tie Y-Y, Zhang Y, Chen W-Q, Ji X-P, Mao Y, Qiao L et al. ( 2017 ) . DKK3 overexpression attenuates cardiac hypertrophy and fibrosis in an angiotensin-perfused animal model by regulating the ADAM17/ACE2 and GSK-3β/β-catenin pathways . Journal of Molecular and Cellular Cardiology vol. 114 , 243 - 252 .

Le Bras A, Yu B, Bhaloo SI, Hong X, Zhang Z, Hu Y, Xu Q ( 2017 ) . Adventitial Sca1+ Cells Transduced With ETV2 Are Committed to the Endothelial Fate and Improve Vascular Remodeling After Injury . Arteriosclerosis Thrombosis and Vascular Biology vol. 38 , ( 1 ) 232 - 244 .

Zhao G, Fu Y, Cai Z, Yu F, Gong Z, Dai R, Hu Y, Zeng L et al. ( 2017 ) . Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic Aneurysm Formation via FoxO4 Interaction . Circulation Research vol. 121 , ( 12 ) 1331 - 1345 .

Xie Y, Potter CMF, Le Bras A, Nowak WN, Gu W, Bhaloo SI, Zhang Z, Hu Y et al. ( 2017 ) . Leptin Induces Sca-1+ Progenitor Cell Migration Enhancing Neointimal Lesions in Vessel-Injury Mouse Models . Arteriosclerosis Thrombosis and Vascular Biology vol. 37 , ( 11 ) 2114 - 2127 .

Jain T, Nikolopoulou EA, Xu Q, Qu A ( 2017 ) . Hypoxia inducible factor as a therapeutic target for atherosclerosis . Pharmacology & Therapeutics vol. 183 , 22 - 33 .

Zhang L, Chen Q, An W, Yang F, Maguire EM, Chen D, Zhang C, Wen G et al. ( 2017 ) . Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia . Arterioscler Thromb Vasc Biol vol. 37 , ( 11 ) 2182 - 2194 .

Maguire EM, Xiao Q, Xu Q ( 2017 ) . Differentiation and Application of Induced Pluripotent Stem Cell–Derived Vascular Smooth Muscle Cells . Arteriosclerosis Thrombosis and Vascular Biology vol. 37 , ( 11 ) 2026 - 2037 .

Kokkinopoulos I, Wong MM, Potter CMF, Xie Y, Yu B, Warren DT, Nowak WN, Le Bras A et al. ( 2017 ) . Adventitial SCA-1+ Progenitor Cell Gene Sequencing Reveals the Mechanisms of Cell Migration in Response to Hyperlipidemia . Stem Cell Reports vol. 9 , ( 2 ) 681 - 696 .

Hong X, Margariti A, Le Bras A, Jacquet L, Kong W, Hu Y, Xu Q ( 2017 ) . Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration . Scientific Reports vol. 7 , ( 1 )

Yu B, Chen Q, Le Bras A, Zhang L, Xu Q ( 2017 ) . Vascular Stem/Progenitor Cell Migration and Differentiation in Atherosclerosis . Antioxidants & Redox Signaling vol. 29 , ( 2 ) 219 - 235 .

Yu B, Kiechl S, Qi D, Wang X, Song Y, Weger S, Mayr A, Le Bras A et al. ( 2017 ) . A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective . Circulation vol. 136 , ( 11 ) 1022 - 1036 .

He L, Huang X, Kanisicak O, Li Y, Wang Y, Li Y, Pu W, Liu Q et al. ( 2017 ) . Preexisting endothelial cells mediate cardiac neovascularization after injury . Journal of Clinical Investigation vol. 127 , ( 8 ) 2968 - 2981 .

Wang Z, Wu Y, Wang J, Zhang C, Yan H, Zhu M, Wang K, Li C et al. ( 2017 ) . Effect of Resveratrol on Modulation of Endothelial Cells and Macrophages for Rapid Vascular Regeneration from Electrospun Poly(ε-caprolactone) Scaffolds . ACS Applied Materials & Interfaces vol. 9 , ( 23 ) 19541 - 19551 .

Nowak WN, Deng J, Ruan XZ, Xu Q ( 2017 ) . Reactive Oxygen Species Generation and Atherosclerosis . Arteriosclerosis Thrombosis and Vascular Biology vol. 37 , ( 5 ) e41 - e52 .

Cochrane A, Kelaini S, Tsifaki M, Bojdo J, Vilà‐González M, Drehmer D, Caines R, Magee C et al. ( 2017 ) . Quaking Is a Key Regulator of Endothelial Cell Differentiation, Neovascularization, and Angiogenesis . Stem Cells vol. 35 , ( 4 ) 952 - 966 .

Gu W, Hong X, Potter C, Qu A, Xu Q ( 2017 ) . Mesenchymal stem cells and vascular regeneration . Microcirculation vol. 24 , ( 1 )

Zhang L, Xu Q ( 2017 ) . Vascular Progenitors and Smooth Muscle Cells Chicken and Egg? . Circulation Research vol. 120 , ( 2 ) 246 - 248 .

Deng J, Lü S, Liu H, Liu B, Jiang C, Xu Q, Feng J, Wang X ( 2017 ) . Homocysteine Activates B Cells via Regulating PKM2-Dependent Metabolic Reprogramming . The Journal of Immunology vol. 198 , ( 1 ) 170 - 183 .

Mandal K, Foteinos G, Jahangiri M, Xu Q ( 2016 ) . Role of antiheat shock protein 60 autoantibodies in atherosclerosis . Lupus vol. 14 , ( 9 ) 742 - 746 .

Yu B, Wong MM, Potter CMF, Simpson RML, Karamariti E, Zhang Z, Zeng L, Warren D et al. ( 2016 ) . Vascular Stem/Progenitor Cell Migration Induced by Smooth Muscle Cell-Derived Chemokine (C-C Motif) Ligand 2 and Chemokine (C-X-C motif) Ligand 1 Contributes to Neointima Formation . Stem Cells vol. 34 , ( 9 ) 2368 - 2380 .

Zhao Y, Li Y, Luo P, Gao Y, Yang J, Lao K-H, Wang G, Cockerill G et al. ( 2016 ) . XBP1 splicing triggers miR-150 transfer from smooth muscle cells to endothelial cells via extracellular vesicles . Scientific Reports vol. 6 , ( 1 )

Karamariti E, Zhai C, Yu B, Niehrs C, Hu Y, Zhang C, Xu Q ( 2016 ) . B DKK3 Stabilises Atherosclerotic Plaque via Promoting Vascular Progenitor and Fibroblast Differentiation to Smooth Muscle Cells . Heart vol. 102 , ( Suppl 6 )

Fu Y, Gao C, Liang Y, Wang M, Huang Y, Ma W, Li T, Jia Y et al. ( 2016 ) . Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification . Circulation Research vol. 119 , ( 2 ) 261 - 276 .

Xie Y, Fan Y, Xu Q ( 2016 ) . Vascular Regeneration by Stem/Progenitor Cells . Arteriosclerosis Thrombosis and Vascular Biology vol. 36 , ( 5 ) e33 - e40 .

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Hong X, Le Bras A, Margariti A, Xu Q ( 2016 ) . Reprogramming towards endothelial cells for vascular regeneration . Genes & Diseases vol. 3 , ( 3 ) 186 - 197 .

Luo Y, Feng J, Xu Q, Wang W, Wang X ( 2016 ) . NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1 . Circulation Research vol. 118 , ( 6 ) 944 - 956 .

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Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, Zampetaki A, Yin X et al. ( 2015 ) . XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling . Arteriosclerosis Thrombosis and Vascular Biology vol. 35 , ( 10 ) 2134 - 2144 .

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Wang X, Karamariti E, Simpson R, Wang W, Xu Q ( 2015 ) . Dickkopf Homolog 3 Induces Stem Cell Differentiation into Smooth Muscle Lineage via ATF6 Signalling* . Journal of Biological Chemistry vol. 290 , ( 32 ) 19844 - 19852 .

Wang G, Jacquet L, Karamariti E, Xu Q ( 2015 ) . Origin and differentiation of vascular smooth muscle cells . The Journal of Physiology vol. 593 , ( 14 ) 3013 - 3030 .

Hong X, Margariti A, Jacquet L, Le Bras A, Hu Y, Xu Q ( 2015 ) . 222 Generation of Functional Endothelial-Like Cells Enabling Therapeutic Angiogenesis from Human Smooth Muscle Cells . Heart vol. 101 , ( Suppl 4 )

Wang Z, Lu Y, Qin K, Wu Y, Tian Y, Wang J, Zhang J, Hou J et al. ( 2015 ) . Enzyme-functionalized vascular grafts catalyze in-situ release of nitric oxide from exogenous NO prodrug . Journal of Controlled Release vol. 210 , 179 - 188 .

Campagnolo P, Tsai T-N, Hong X, Kirton JP, So P-W, Margariti A, Di Bernardini E, Wong MM et al. ( 2015 ) . c-Kit+ progenitors generate vascular cells for tissue-engineered grafts through modulation of the Wnt/Klf4 pathway . Biomaterials vol. 60 , 53 - 61 .

Campagnolo P, Hong X, di Bernardini E, Smyrnias I, Hu Y, Xu Q ( 2015 ) . Resveratrol-Induced Vascular Progenitor Differentiation towards Endothelial Lineage via MiR-21/Akt/β-Catenin Is Protective in Vessel Graft Models . PLOS ONE vol. 10 , ( 5 )

Yu B, Wong MM, Wang W, Hu Y, Xu Q ( 2015 ) . Abstract 200: Vascular Stem Cell Migration in Response to Monocyte Chemoattractant Protein-1 Promotes Neointima Lesion Formation . Arteriosclerosis Thrombosis and Vascular Biology vol. 35 , ( suppl_1 )

Yu B, Wong MM, Potter C, Hu Y, Wang W, Xu Q ( 2015 ) . Abstract 9: Smooth Muscle Cells Are Crucial for Vascular Stem Cell Migration and Vasculogenesis via Keratinocyte Cell-derived Chemokine . Arteriosclerosis Thrombosis and Vascular Biology vol. 35 , ( suppl_1 )

Chen T, Margariti A, Kelaini S, Cochrane A, Guha ST, Hu Y, Stitt AW, Zhang L et al. ( 2015 ) . MicroRNA‐199b Modulates Vascular Cell Fate During iPS Cell Differentiation by Targeting the Notch Ligand Jagged1 and Enhancing VEGF Signaling . Stem Cells vol. 33 , ( 5 ) 1405 - 1418 .

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Martin D, Li Y, Yang J, Wang G, Margariti A, Jiang Z, Yu H, Zampetaki A et al. ( 2014 ) . Unspliced X-box-binding Protein 1 (XBP1) Protects Endothelial Cells from Oxidative Stress through Interaction with Histone Deacetylase 3* . Journal of Biological Chemistry vol. 289 , ( 44 ) 30625 - 30634 .

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Zeng L, Li Y, Yang J, Hu Y, Xu Q ( 2014 ) . Abstract 357: The Role of X-Box Binding Protein 1 Splicing in Smooth Muscle Cell Proliferation and Neointima Formation . Arteriosclerosis Thrombosis and Vascular Biology vol. 34 , ( suppl_1 )

Jones SG, Hu Y, Xu Q, Jahangiri M ( 2014 ) . Stem Cells Accumulate on a Decellularized Arterial Xenograft In Vivo . The Annals of Thoracic Surgery vol. 97 , ( 6 ) 2104 - 2110 .

Zeng L, Li Y, Hu Y, Xu Q ( 2014 ) . The role of X-box binding protein 1 splicing in smooth muscle cell proliferation and neointima formation . Atherosclerosis vol. 232 , ( 2 )

Wong MM, Chen Y, Margariti A, Winkler B, Campagnolo P, Potter C, Hu Y, Xu Q ( 2014 ) . Macrophages Control Vascular Stem/Progenitor Cell Plasticity Through Tumor Necrosis Factor-&agr;–Mediated Nuclear Factor-&kgr;B Activation . Arteriosclerosis Thrombosis and Vascular Biology vol. 34 , ( 3 ) 635 - 643 .

Warboys CM, Chen N, Zhang Q, Shaifta Y, Vanderslott G, Passacquale G, Hu Y, Xu Q et al. ( 2014 ) . 25 Nitric Oxide-cGMP Signalling Promotes B-Catenin Nuclear Translocation and Transcriptional Activity in Endothelial Cells . Heart vol. 100 , ( Suppl 1 )

Wong MM, Yin X, Potter C, Yu B, Cai H, Di Bernardini E, Xu Q ( 2014 ) . Over-Expression of HSP47 Augments Mouse Embryonic Stem Cell Smooth Muscle Differentiation and Chemotaxis . PLoS ONE vol. 9 , ( 1 )

Di Bernardini E, Campagnolo P, Margariti A, Zampetaki A, Karamariti E, Hu Y, Xu Q ( 2013 ) . Endothelial Lineage Differentiation from Induced Pluripotent Stem Cells Is Regulated by MicroRNA-21 and Transforming Growth Factor β2 (TGF-β2) Pathways* . Journal of Biological Chemistry vol. 289 , ( 6 ) 3383 - 3393 .

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Wong MM, Winkler B, Karamariti E, Wang X, Yu B, Simpson R, Chen T, Margariti A et al. ( 2013 ) . Sirolimus Stimulates Vascular Stem/Progenitor Cell Migration and Differentiation Into Smooth Muscle Cells via Epidermal Growth Factor Receptor/Extracellular Signal–Regulated Kinase/β-Catenin Signaling Pathway . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 33 , ( 10 ) 2397 - 2406 .

Zeng L, Wang G, Ummarino D, Margariti A, Xu Q, Xiao Q, Wang W, Zhang Z et al. ( 2013 ) . Histone Deacetylase 3 Unconventional Splicing Mediates Endothelial-to-mesenchymal Transition through Transforming Growth Factor β2* . Journal of Biological Chemistry vol. 288 , ( 44 ) 31853 - 31866 .

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Chen Y, Wong MM, Campagnolo P, Simpson R, Winkler B, Margariti A, Hu Y, Xu Q ( 2013 ) . Adventitial Stem Cells in Vein Grafts Display Multilineage Potential That Contributes to Neointimal Formation . Arteriosclerosis Thrombosis and Vascular Biology vol. 33 , ( 8 ) 1844 - 1851 .

Campagnolo P, Hong X, Hu Y, Xu Q ( 2013 ) . 161 RESVERATROL REDUCES VESSEL-GRAFT NEOINTIMAL FORMATION BY INDUCING ENDOTHELIAL DIFFERENTIATION OF RESIDENT PROGENITOR CELLS THROUGH A MIR-21/AKT/B-CATENIN PATHWAY . Heart vol. 99 , ( suppl 2 )

Di Bernardini E, Campagnolo P, Margariti A, Zampetaki A, Mayer M, Hu Y, Xu Q ( 2013 ) . 183 ENDOTHELIAL LINEAGE DIFFERENTIATION FROM IPS CELLS IS REGULATED BY MIRNA-21/AKT AND TGF-Β2 PATHWAYS . Heart vol. 99 , ( suppl 2 )

Xu Q, Karamariti E, Margariti A, Hu Y ( 2013 ) . 185 SMOOTH MUSCLE CELLS DIFFERENTIATED FROM REPROGRAMMED FIBROBLASTS THROUGH DKK3 SIGNALLING ARE POTENT FOR TISSUE ENGINEERING OF VASCULAR GRAFTS . Heart vol. 99 , ( suppl 2 )

Simpson R, Hong X, Xu Q ( 2013 ) . 198 HYALURONAN IS REQUIRED FOR SMOOTH MUSCLE CELL DIFFERENTIATION FROM STEM CELLS . Heart vol. 99 , ( suppl 2 )

Margariti A, Hu Y, Stitt AW, Xu Q ( 2013 ) . 212 HUMAN INDUCED PLURIPOTENT STEM CELLS DIFFERENTIATE INTO PURE POPULATIONS OF ENDOTHELIAL CELLS MEDIATED BY SET SIMILAR PROTEIN THROUGH VE-CADHERIN TRANSCRIPTIONAL ACTIVATION . Heart vol. 99 , ( suppl 2 )

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Zeng L, Xiao Q, Chen M, Margariti A, Martin D, Ivetic A, Xu H, Mason J et al. ( 2013 ) . Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis . Circulation vol. 127 , ( 16 ) 1712 - 1722 .

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Li Y, Liu S, Zhang Z, Xu Q, Xie F, Wang J, Ping S, Li C et al. ( 2012 ) . RAGE Mediates Accelerated Diabetic Vein Graft Atherosclerosis Induced by Combined Mechanical Stress and AGEs via Synergistic ERK Activation . PLOS ONE vol. 7 , ( 4 )

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Alam S, Li H, Margariti A, Martin D, Zampetaki A, Habi O, Cockerill G, Hu Y et al. ( 2011 ) . Galectin-9 Protein Expression in Endothelial Cells Is Positively Regulated by Histone Deacetylase 3* . Journal of Biological Chemistry vol. 286 , ( 51 ) 44211 - 44217 .

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Margariti A, Winkler B, Karamariti E, Tsai T, Zeng L, Hu Y, Xu Q ( 2011 ) . 20 Direct reprogramming fibroblasts into endothelial cells . Heart vol. 97 , ( 20 )

Margariti A, Kirton JP, Yin X, Karamariti E, Mayr M, Hu Y, Zeng L, Xu Q ( 2011 ) . 21 Proteomic analysis of iPS and embryonic stem cells identifies alternate vascular cell differentiation properties . Heart vol. 97 , ( 20 )

Wang G, Xiao Q, Xu Q ( 2011 ) . 4 Stem cell differentiation to smooth muscle cells is regulated by HnRNP A2/B1 . Heart vol. 97 , ( 20 )

Campagnolo P, Kirton JP, Tsai T, Di Bernardini E, Xu Q ( 2011 ) . 50 Embryonic and IPS cell-derived cKit+ cells represent a novel vascular progenitor cell population . Heart vol. 97 , ( 20 )

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Kiechl S, Laxton RC, Xiao Q, Hernesniemi JA, Raitakari OT, Kähönen M, Mayosi BM, Jula A et al. ( 2010 ) . Coronary Artery Disease-Related Genetic Variant on Chromosome 10q11 Is Associated With Carotid Intima-Media Thickness and Atherosclerosis . Arteriosclerosis Thrombosis and Vascular Biology vol. 30 , ( 12 ) 2678 - 2683 .

Rossini A, Frati C, Lagrasta C, Graiani G, Scopece A, Cavalli S, Musso E, Baccarin M et al. ( 2010 ) . Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin . Cardiovascular Research vol. 89 , ( 3 ) 650 - 660 .

xiao Q, Wang G, Luo Z, Xu Q ( 2010 ) . The mechanism of stem cell differentiation into smooth muscle cells . Thromb Haemost vol. 104 , ( 3 ) 440 - 448 .

Stegemann C, Shalhoub J, Jenkins J, Davies AH, Ladroue C, Monaco C, Smith A, Xu Q et al. ( 2010 ) . BAS/BSCR14 Lipidomic profiling of human atherosclerotic plaques . Heart vol. 96 , ( 17 )

Alam S, Li H, Martin D, Zampetaki A, Hu Y, Xu Q, Zeng L ( 2010 ) . BAS/BSCR26 Histone deacetylase 3 protects endothelial cells from inflammation via regulation of galectin 9 expression . Heart vol. 96 , ( 17 )

Xiao Q, Wang G, Bai X, Yin X, Luo Z, Mayr M, Ye S, Xu Q ( 2010 ) . BAS/BSCR30 Crucial roles of Cbx3 identified by nuclear proteomics in smooth muscle differentiation from stem cells and vascular injury-induced neointima formation . Heart vol. 96 , ( 17 )

Zampetaki A, May D, Oren G, Yin X, Xu Q, Horrevoets A, Keshet E, Mayr M ( 2010 ) . BAS/BSCR31 Metabolic homoeostasis is maintained in myocardial hibernation by adaptive changes in the transcriptome and proteome . Heart vol. 96 , ( 17 )

Zeng L, Xiao Q, Li H, Margariti A, Hu Y, Xu Q ( 2010 ) . BAS/BSCR43 X-box binding protein 1 splicing is crucial in endothelial cell proliferation . Heart vol. 96 , ( 17 )

Margariti A, Li H, Martin D, Zampetaki A, Hu Y, Xu Q, Zeng L ( 2010 ) . BAS/BSCR46 X-box binding protein 1 splicing triggers an autophagic survival pathway in endothelial cells . Heart vol. 96 , ( 17 )

Martin D, Li H, Zampetaki A, Hu Y, Zeng L, Xu Q ( 2010 ) . YIA1 Interaction between HDAC3 and XBP1 is critical in maintainence of endothelial integrity . Heart vol. 96 , ( 17 )

Bai X, Margariti A, Zeng L, Hu Y, Xu Q ( 2010 ) . YIA5 PKCδ deficiency accelerates neointimal lesions in a mouse model of vascular injury involving delayed re-endothelialisation and vasohibin-1 accumulation . Heart vol. 96 , ( 17 )

Zhang F, Hu Y, Xu Q, Ye S ( 2010 ) . Different Effects of Angiotensin II and Angiotensin-(1-7) on Vascular Smooth Muscle Cell Proliferation and Migration . PLOS ONE vol. 5 , ( 8 )

Kirton JP, Tsai T-N, Xu Q ( 2010 ) . Cells and Vascular Tissue Engineering . Stem Cell Engineering , Springer Nature

Fleissner F, Jazbutyte V, Fiedler J, Gupta SK, Yin X, Xu Q, Galuppo P, Kneitz S et al. ( 2010 ) . Short Communication: Asymmetric Dimethylarginine Impairs Angiogenic Progenitor Cell Function in Patients With Coronary Artery Disease Through a MicroRNA-21–Dependent Mechanism . Circulation Research vol. 107 , ( 1 ) 138 - 143 .

Simper D, Mayr U, Urbich C, Zampetaki A, Prokopi M, Didangelos A, Saje A, Mueller M et al. ( 2010 ) . Comparative Proteomics Profiling Reveals Role of Smooth Muscle Progenitors in Extracellular Matrix Production . Arteriosclerosis Thrombosis and Vascular Biology vol. 30 , ( 7 ) 1325 - 1332 .

Margariti A, Zampetaki A, Xiao Q, Zou B, Karamariti E, Martin D, Yin X, Mayr M et al. ( 2010 ) . Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin . Circ Res. vol. 106 , ( 7 ) 1202 - 1211 .

Pepe AE, Xiao Q, Zampetaki A, Zhang Z, Kobayashi A, Hu Y, Xu Q ( 2010 ) . Crucial role of nrf3 in smooth muscle cell differentiation from stem cells . Circ Res. vol. 106 , ( 5 ) 870 - 879 .

Kirton JP, Xu Q ( 2010 ) . Endothelial precursors in vascular repair . Microvascular Research vol. 79 , ( 3 ) 193 - 199 .

Bai X, Wang X, Xu Q ( 2010 ) . Endothelial damage and stem cell repair in atherosclerosis . Vascular Pharmacology vol. 52 , ( 5-6 ) 224 - 229 .

Zampetaki A, Zeng L, Margariti A, Xiao Q, Li H, Zhang Z, Pepe AE, Wang G et al. ( 2010 ) . Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow . Circulation vol. 121 , ( 1 ) 132 - 142 .

Zeng L, Zampetaki A, Xu Q ( 2010 ) . Endothelial cell proliferation and differentiation in response to shear stress . Hemodynamics and Mechanobiology of Endothelium ,

Wang L, Zheng J, Du Y, Huang Y, Li J, Liu B, Liu C-J, Zhu Y et al. ( 2009 ) . Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With &agr;7&bgr;1 Integrin . Circulation Research vol. 106 , ( 3 ) 514 - 525 .

Kiechl S, Laxton RC, Xiao Q, Willeit J, Xu Q, Ye S ( 2009 ) . CAD RELATED VARIATION ON CHROMOSOME 10q11 IS ASSOCIATED WITH CIRCULATING SDF-1ALPHA LEVEL AND CAROTID INTIMA-MEDIA THICKNESS AND ATHEROSCLEROSIS . Atherosclerosis . vol. 207 ,

Foteinos G, Xu Q ( 2009 ) . Immune-mediated mechanisms of endothelial damage in atherosclerosis . Autoimmunity vol. 42 , ( 7 ) 627 - 633 .

Jiang C, Zhang H, Zhang W, Kong W, Zhu Y, Zhang H, Xu Q, Li Y et al. ( 2009 ) . Homocysteine promotes vascular smooth muscle cell migration by induction of the adipokine resistin . American Journal of Physiology - Cell Physiology vol. 297 , ( 6 ) c1466 - c1476 .

Wick G, Kleindienst R, Schett G, Amberger A, Xu Q ( 2009 ) . Role of Heat Shock Protein 65/60 in the Pathogenesis of Atherosclerosis . International Archives of Allergy and Immunology vol. 107 , ( 1-3 ) 130 - 131 .

Schett G, Metzler B, Kleindienst R, Moschèn I, Hattmannsdorfer R, Wolf H, Ottenhoff T, Xu Q et al. ( 2009 ) . Salivary Anti-hsp65 Antibodies as a Diagnostic Marker for Gingivitis and a Possible Link to Atherosclerosis . International Archives of Allergy and Immunology vol. 114 , ( 3 ) 246 - 250 .

Metzler B, Xu Q ( 2009 ) . The Role of Mast Cells in Atherosclerosis . International Archives of Allergy and Immunology vol. 114 , ( 1 ) 10 - 14 .

Ye S, Willeit J, Xiao Q, Motterle A, Laxton RC, Oberhollenzer F, Kiechl S, Xu Q ( 2009 ) . Single nucleotide polymorphism on chromosome 9p21 and endothelial progenitor cells in a general population cohort . Atherosclerosis vol. 208 , ( 2 ) 451 - 455 .

Xu Q ( 2009 ) . Disturbed Flow-Enhanced Endothelial Turnover in Atherosclerosis . Trends in Cardiovascular Medicine vol. 19 , ( 6 ) 191 - 195 .

Qu A, Jiang C, Xu M, Zhang Y, Zhu Y, Xu Q, Zhang C, Wang X ( 2009 ) . PGC-1α attenuates neointimal formation via inhibition of vascular smooth muscle cell migration in the injured rat carotid artery . American Journal of Physiology - Cell Physiology vol. 297 , ( 3 ) c645 - c653 .

Feng J, Zhang Z, Kong W, Liu B, Xu Q, Wang X ( 2009 ) . Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apoE−/− mice . Cardiovascular Research vol. 84 , ( 1 ) 155 - 163 .

Zeng L, Zampetaki A, Margariti A, Pepe AE, Alam S, Martin D, Xiao Q, Wang W et al. ( 2009 ) . Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow . Proceedings of the National Academy of Sciences of the United States of America vol. 106 , ( 20 ) 8326 - 8331 .

Mayr M, Grainger D, Mayr U, Leroyer AS, Leseche G, Sidibe A, Herbin O, Yin X et al. ( 2009 ) . Proteomics, Metabolomics, and Immunomics on Microparticles Derived From Human Atherosclerotic Plaques . Circulation Genomic and Precision Medicine vol. 2 , ( 4 ) 379 - 388 .

Prokopi M, Pula G, Mayr U, Devue C, Gallagher J, Xiao Q, Boulanger CM, Westwood N et al. ( 2009 ) . Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures . Blood vol. 114 , ( 3 ) 723 - 732 .

Xiao Q, Xu Q ( 2009 ) . Caspase-8, a double-edged sword for EPC functioning . Arterioscler Thromb Vasc Biol. vol. 29 , ( 4 ) 444 - 446 .

Xiao Q, Luo Z, Pepe AE, Margariti A, Zeng L, Xu Q ( 2009 ) . Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2 . Am J Physiol Cell Physiol. vol. 296 , ( 4 ) C711 - C723 .

Margariti A, Xiao Q, Zampetaki A, Zhang Z, Li H, Martin D, Hu Y, Zeng L et al. ( 2009 ) . Splicing of HDAC7 modulates the SRF-myocardin complex during stem-cell differentiation towards smooth muscle cells . Journal of Cell Science vol. 122 , ( 4 ) 460 - 470 .

Wang L, Zheng J, Bai X, Liu B, Liu C-J, Xu Q, Zhu Y, Wang N et al. ( 2009 ) . ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-Injured Rat Arteries . Circulation Research vol. 104 , ( 5 ) 688 - 698 .

Pula G, Mayr U, Evans C, Prokopi M, Vara DS, Yin X, Astroulakis Z, Xiao Q et al. ( 2009 ) . Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures . Circ Res. vol. 104 , ( 1 ) 32 - 40 .

Laxton RC, Hu YH, Duchene J, Zhang F, Zhang ZY, Leung KY, Xiao QZ, Scotland RS et al. ( 2009 ) . A Role of Matrix Metalloproteinase-8 in Atherosclerosis . Circ.Res. vol. 105 , ( 9 ) 921 - U231 .

Zampetaki A, Xu Q ( 2009 ) . Vascular Remodeling in Diabetes . Arteriosclerosis Thrombosis and Vascular Biology vol. 29 , ( 1 ) 10 - 11 .

Kiechl S, Lee T, Santer P, Thompson G, Tsimikas S, Egger G, Holt DW, Willeit J et al. ( 2008 ) . Asymmetric and symmetric dimethylarginines are of similar predictive value for cardiovascular risk in the general population . Atherosclerosis vol. 205 , ( 1 ) 261 - 265 .

Dai J, Wang X, Feng J, Kong W, Xu Q, Shen X, Wang X ( 2008 ) . Regulatory role of thioredoxin in homocysteine‐induced monocyte chemoattractant protein‐1 secretion in monocytes/macrophages . FEBS Letters vol. 582 , ( 28 ) 3893 - 3898 .

Mayr M, Liem D, Zhang J, Li X, Avliyakulov NK, Yang JI, Young G, Vondriska TM et al. ( 2008 ) . Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts . Journal of Molecular and Cellular Cardiology vol. 46 , ( 2 ) 268 - 277 .

Wang Q-Q, Ping B-H, Xu Q-B, Wang W ( 2008 ) . Rheological Effects of Blood in a Nonplanar Distal End-to-Side Anastomosis . Journal of Biomechanical Engineering vol. 130 , ( 5 )

Margariti A, Xiao Q, Zampetaki A, Zhang Z, Li H, Hu Y, Zeng L, Xu Q ( 2008 ) . HISTONE DEACETYLASE 7 IS ESSENTIAL FOR STEM CELL DIFFERENTIATION INTO SMOOTH MUSCLE CELLS . Atherosclerosis . vol. 199 ,

Hu Y, Foteinos G, Xiao Q, Xu Q ( 2008 ) . RAPID ENDOTHELIAL TURNOVER IN ATHEROSCLEROSIS-PRONE AREAS COINCIDES WITH STEM CELL REPAIR IN APOE-DEFICIENT MICE . Atherosclerosis . vol. 199 ,

Zeng L, Zampetaki A, Margariti A, Li H, Zhang Z, Xiao Q, Hu Y, Xu Q ( 2008 ) . XBP1 IS A KEY PROTEIN INDUCING ENDOTHELIAL CELL DEATH IN VIVO AND IN VITRO . Atherosclerosis . vol. 199 , 465 - 466 .

Tsimikas S, Willeit J, Knoflach M, Mayr M, Egger G, Notdurfter M, Witztum JL, Wiedermann CJ et al. ( 2008 ) . Lipoprotein-associated phospholipase A2 activity, ferritin levels, metabolic syndrome, and 10-year cardiovascular and non-cardiovascular mortality: results from the Bruneck study . European Heart Journal vol. 30 , ( 1 ) 107 - 115 .

Metzler B, Xu Q, Mayr M ( 2008 ) . Letter by Metzler et al Regarding Article, “Intracoronary KAI-9803 as an Adjunct to Primary Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction” . Circulation vol. 118 , ( 4 )

Zeng L, Xu Q ( 2008 ) . eNOS–ER&agr; Complex Goes to Telomerase . Circulation Research vol. 103 , ( 1 ) 10 - 12 .

Metzler B, Haubner B, Conci E, Voelkl J, Jehle J, Bauer M, Wolf D, Pachinger O et al. ( 2008 ) . Myocardial ischaemia-reperfusion injury in haematopoietic cell-restricted beta1 integrin knockout mice . Exp.Physiol. vol. 93 , ( 7 ) 825 - 833 .

Xu Q ( 2008 ) . Stem Cells and Transplant Arteriosclerosis . Circulation Research vol. 102 , ( 9 ) 1011 - 1024 .

Afzal AR, Kiechl S, Daryani YP, Weerasinghe A, Zhang Y, Reindl M, Mayr A, Weger S et al. ( 2008 ) . Common CCR5-del32 Frameshift Mutation Associated With Serum Levels of Inflammatory Markers and Cardiovascular Disease Risk in the Bruneck Population . Stroke vol. 39 , ( 7 ) 1972 - 1978 .

Mayr M, Zampetaki A, Sidibe A, Mayr U, Yin X, De Souza AI, Chung Y-L, Madhu B et al. ( 2008 ) . Proteomic and Metabolomic Analysis of Smooth Muscle Cells Derived From the Arterial Media and Adventitial Progenitors of Apolipoprotein E–Deficient Mice . Circulation Research vol. 102 , ( 9 ) 1046 - 1056 .

Foteinos G, Hu Y, Xiao Q, Metzler B, Xu Q ( 2008 ) . Rapid Endothelial Turnover in Atherosclerosis-Prone Areas Coincides With Stem Cell Repair in Apolipoprotein E–Deficient Mice . Circulation vol. 117 , ( 14 ) 1856 - 1863 .

Hu Y, Xu Q ( 2008 ) . Vessel graft atherosclerosis in murine models . Current Drug Targets vol. 9 , ( 3 ) 239 - 250 .

Mayr M, Yusuf S, Weir G, Chung Y-L, Mayr U, Yin X, Ladroue C, Madhu B et al. ( 2008 ) . Combined Metabolomic and Proteomic Analysis of Human Atrial Fibrillation . Journal of the American College of Cardiology vol. 51 , ( 5 ) 585 - 594 .

Zampetaki A, Kirton JP, Xu Q ( 2008 ) . Vascular repair by endothelial progenitor cells . Cardiovascular Research vol. 78 , ( 3 ) 413 - 421 .

YE S, WILLEIT J, KRONENBERG F, XU Q, KIECHL S ( 2008 ) . Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis - A population-based, prospective study . J Am Coll Cardiol vol. 52 , ( 5 ) 378 - 384 .

Xiao Q, Ye S, Oberhollenzer F, Mayr A, Jahangiri M, Willeit J, Kiechl S, Xu Q ( 2008 ) . SDF1 gene variation is associated with circulating SDF1alpha level and endothelial progenitor cell number: the Bruneck Study . PLoS One vol. 3 , ( 12 )

Xu Q-B, Wang X ( 2007 ) . [Updates on atherogenesis: the stem/progenitor cells hypothesis] . 中华病理学杂志 vol. 36 , ( 12 ) 793 - 795 .

Mandal K, Jahangiri M, Xu Q ( 2007 ) . Progenitor Cells and Vascular Repair . Cardiovascular Regeneration and Stem Cell Therapy , Wiley

Adams B, Xiao Q, Xu Q ( 2007 ) . Vascular progenitor cells and atherosclerosis . Future Cardiology vol. 3 , ( 6 ) 635 - 645 .

Xu Q ( 2007 ) . The role of stem cells in vein graft remodelling . Biochemical Society Transactions . vol. 35 , 895 - 899 .

Qi XW, Liu HF, Xue YZ, Kong XQ, Xu QB, Xiao QZ ( 2007 ) . Changes of endothelial progenitor cells and vascular endothelial growth factor in patients with coronary artery disease . Journal of Clinical Rehabilitative Tissue Engineering Research vol. 11 , ( 42 ) 8439 - 8443 .

Simper D, Mayr U, Benbow U, Newby A, Xu Q, Mayr M ( 2007 ) . Abstract 1162: Proteomic Characterization of the Secretome of Peripheral Blood-derived Smooth Muscle Progenitors . Circulation vol. 116 , ( suppl_16 )

Margariti A, Xiao Q, Zampetaki A, Hu Y, Zeng L, Xu Q ( 2007 ) . Abstract 433: HDAC7 is Essential for Stem Cell Differentiation into Smooth Muscle Cells . Circulation vol. 116 , ( suppl_16 )

Afzal AR, Mandal K, Nyamweya S, Foteinos G, Poloniecki J, Camm AJ, Jahangiri M, Xu Q ( 2007 ) . Association of Met439Thr Substitution in Heat Shock Protein 70 Gene with Postoperative Atrial Fibrillation and Serum HSP70 Protein Levels . Cardiology vol. 110 , ( 1 ) 45 - 52 .

Xiao Q, Kiechl S, Patel S, Oberhollenzer F, Weger S, Mayr A, Metzler B, Reindl M et al. ( 2007 ) . Endothelial Progenitor Cells, Cardiovascular Risk Factors, Cytokine Levels and Atherosclerosis – Results from a Large Population-Based Study . PLOS ONE vol. 2 , ( 10 )

Xu Q ( 2007 ) . Progenitor cells in vascular repair . Current Opinion in Lipidology vol. 18 , ( 5 ) 534 - 539 .

Adams B, Xiao Q, Xu Q ( 2007 ) . Stem Cell Therapy for Vascular Disease . Trends in Cardiovascular Medicine vol. 17 , ( 7 ) 246 - 251 .

Xiao Q, Kiechl S, Patel S, Oberhollenzer F, Weger S, Mayr A, Metzler B, Reindl M et al. ( 2007 ) . Endothelial progenitor cells, cardiovascular risk factors, cytokines levels and atherosclerosis-results from a large population-based study . Atherosclerosis . vol. 193 ,

Sidibe A, Yin X, Tarelli E, Xiao Q, Zampetaki A, Xu Q, Mayr M ( 2007 ) . Integrated Membrane Protein Analysis of Mature and Embryonic Stem Cell-derived Smooth Muscle Cells Using a Novel Combination of CyDye/Biotin Labeling * . Molecular & Cellular Proteomics vol. 6 , ( 10 ) 1788 - 1797 .

Zampetaki A, Zeng L, Xiao Q, Margariti A, Hu Y, Xu Q ( 2007 ) . Lacking cytokine production in ES cells and ES-cell-derived vascular cells stimulated by TNF-α is rescued by HDAC inhibitor trichostatin A . American Journal of Physiology - Cell Physiology vol. 293 , ( 4 ) c1226 - c1238 .

Kiechl S, Schett G, Schwaiger J, Seppi K, Eder P, Egger G, Santer P, Mayr A et al. ( 2007 ) . Soluble Receptor Activator of Nuclear Factor-κB Ligand and Risk for Cardiovascular Disease . Circulation vol. 116 , ( 4 ) 385 - 391 .

Kiechl S, Willeit J, Mayr M, Viehweider B, Oberhollenzer M, Kronenberg F, Wiedermann CJ, Oberthaler S et al. ( 2007 ) . Oxidized Phospholipids, Lipoprotein(a), Lipoprotein-Associated Phospholipase A2 Activity, and 10-Year Cardiovascular Outcomes: Prospective Results From the Bruneck Study . Arteriosclerosis Thrombosis and Vascular Biology vol. 27 , ( 8 ) 1788 - 1795 .

Roberts N, Jahangiri M, Xu Q ( 2007 ) . Progenitor cells in vascular disease . Journal of Cellular and Molecular Medicine vol. 9 , ( 3 ) 583 - 591 .

Roberts N, Xiao Q, Weir G, Xu Q, Jahangiri M ( 2007 ) . Endothelial Progenitor Cells are Mobilized After Cardiac Surgery . The Annals of Thoracic Surgery vol. 83 , ( 2 ) 598 - 605 .

Mayr M, Madhu B, Xu Q ( 2007 ) . Proteomics and Metabolomics Combined in Cardiovascular Research . Trends in Cardiovascular Medicine vol. 17 , ( 2 ) 43 - 48 .

Li C, Xu Q ( 2007 ) . Mechanical stress-initiated signal transduction in vascular smooth muscle cells in vitro and in vivo . Cellular Signalling vol. 19 , ( 5 ) 881 - 891 .

Yin X, Mayr M, Xiao Q, Wang W, Xu Q ( 2006 ) . Proteomic analysis reveals higher demand for antioxidant protection in embryonic stem cell‐derived smooth muscle cells . Proteomics vol. 6 , ( 24 ) 6437 - 6446 .

Zeng L, Xiao Q, Margariti A, Zhang Z, Zampetaki A, Patel S, Capogrossi MC, Hu Y et al. ( 2006 ) . HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells . Journal of Cell Biology vol. 174 , ( 7 ) 1059 - 1069 .

Mayr M, Mayr U, Chung Y-L, Yin X, Griffiths JR, Xu Q ( 2006 ) . Combining proteomics and metabolomics in vascular research . Vascular Pharmacology vol. 45 , ( 3 )

Mayr M, Kiechl S, Tsimikas S, Willeit J, Witztum JL, Xu Q ( 2006 ) . Oxidized LDL autoantibodies, chronic infections and carotid atherosclerosis . Vascular Pharmacology vol. 45 , ( 3 )

Yin X, Xiao Q, Mayr U, Mayr M, Xu Q ( 2006 ) . Proteomic analysis of embryonic stem cell-derived smooth muscle cells . Vascular Pharmacology vol. 45 , ( 3 )

Zeng L, Xiao Q, Margariti A, Xu Q ( 2006 ) . Shear stress-induced stem cell differentiation toward endothelial cells is regulated by HDAC-P53-P21 pathways . Vascular Pharmacology vol. 45 , ( 3 )

Margariti A, Zeng L, Xu Q ( 2006 ) . Stem cells, vascular smooth muscle cells and atherosclerosis . Cellular and molecular biology vol. 21 , ( 9 ) 979 - 985 .

Zampetaki A, Xiao Q, Zeng L, Xu Q ( 2006 ) . TLR4 expression in mouse embryonic stem cells and in stem cell-derived vascular cells is regulated by epigenetic modifications . Vascular Pharmacology vol. 45 , ( 3 )

Madeddu P, Emanueli C, Spillmann F, Meloni M, Bouby N, Richer C, Alhenc-Gelas F, Van Weel V et al. ( 2006 ) . Murine models of myocardial and limb ischemia: Diagnostic end-points and relevance to clinical problems . Vascular Pharmacology vol. 45 , ( 5 ) 281 - 301 .

Xiao Q, Zeng L, Zhang Z, Hu Y, Xu Q ( 2006 ) . Stem cell-derived Sca-1+ progenitors differentiate into smooth muscle cells, which is mediated by collagen IV-integrin α1/β1/αv and PDGF receptor pathways . American Journal of Physiology - Cell Physiology vol. 292 , ( 1 ) c342 - c352 .

Xiao Q, Zeng L, Zhang Z, Margariti A, Ali ZA, Channon KM, Xu Q, Hu Y ( 2006 ) . Sca-1+ Progenitors Derived From Embryonic Stem Cells Differentiate Into Endothelial Cells Capable of Vascular Repair After Arterial Injury . Arteriosclerosis Thrombosis and Vascular Biology vol. 26 , ( 10 ) 2244 - 2251 .

Markus HS, Labrum R, Bevan S, Reindl M, Egger G, Wiedermann CJ, Xu Q, Kiechl S et al. ( 2006 ) . Genetic and Acquired Inflammatory Conditions Are Synergistically Associated With Early Carotid Atherosclerosis . Stroke vol. 37 , ( 9 ) 2253 - 2259 .

Bhoday J, de Silva S, Xu Q ( 2006 ) . The molecular mechanisms of vascular restenosis: Which genes are crucial? . Current Vascular Pharmacology vol. 4 , ( 3 ) 269 - 275 .

Torsney E, Mandal K, Halliday A, Jahangiri M, Xu Q ( 2006 ) . Characterisation of progenitor cells in human atherosclerotic vessels . Atherosclerosis vol. 191 , ( 2 ) 259 - 264 .

Zampetaki A, Xiao Q, Zeng L, Hu Y, Xu Q ( 2006 ) . TLR4 expression in mouse embryonic stem cells and in stem cell-derived vascular cells is regulated by epigenetic modifications . Biochemical and Biophysical Research Communications vol. 347 , ( 1 ) 89 - 99 .

Castier Y, Lehoux S, Hu Y, Fonteinos G, Tedgui A, Xu Q ( 2006 ) . Characterization of neointima lesions associated with arteriovenous fistulas in a mouse model . Kidney International vol. 70 , ( 2 ) 315 - 320 .

Mayr M, Kiechl S, Tsimikas S, Miller E, Sheldon J, Willeit J, Witztum JL, Xu Q ( 2006 ) . Oxidized Low-Density Lipoprotein Autoantibodies, Chronic Infections, and Carotid Atherosclerosis in a Population-Based Study . Journal of the American College of Cardiology vol. 47 , ( 12 ) 2436 - 2443 .

Tsimikas S, Kiechl S, Willeit J, Mayr M, Miller ER, Kronenberg F, Xu Q, Bergmark C et al. ( 2006 ) . Oxidized Phospholipids Predict the Presence and Progression of Carotid and Femoral Atherosclerosis and Symptomatic Cardiovascular Disease Five-Year Prospective Results From the Bruneck Study . Journal of the American College of Cardiology vol. 47 , ( 11 ) 2219 - 2228 .

Edfeldt K, Agerberth B, Rottenberg ME, Gudmundsson GH, Wang X-B, Mandal K, Xu Q, Yan Z-Q ( 2006 ) . Involvement of the Antimicrobial Peptide LL-37 in Human Atherosclerosis . Arteriosclerosis Thrombosis and Vascular Biology vol. 26 , ( 7 ) 1551 - 1557 .

Mandal K, Afzal AR, Brecker SJD, Poloniecki J, Xu Q, Jahangiri M ( 2006 ) . Association of serum soluble heat shock protein 60 with toll-like receptor 4 polymorphism and severity of coronary artery disease . Heart vol. 92 , ( 5 )

Xu Q ( 2006 ) . The impact of progenitor cells in atherosclerosis . Nature Clinical Practice Cardiovascular Medicine vol. 3 , ( 2 ) 94 - 101 .

Mayr U, Zou Y, Zhang Z, Dietrich H, Hu Y, Xu Q ( 2005 ) . Accelerated Arteriosclerosis of Vein Grafts in Inducible NO Synthase−/− Mice Is Related to Decreased Endothelial Progenitor Cell Repair . Circulation Research vol. 98 , ( 3 ) 412 - 420 .

Huber LA, Xu Q, Jürgens G, Böck G, Bühler E, Gey KF, Schönitzer D, Traill KN et al. ( 2005 ) . Correlation of lymphocyte lipid composition membrane microviscosity and mitogen response in the aged . European Journal of Immunology vol. 21 , ( 11 ) 2761 - 2765 .

XIAO Q, Mandal K, Schett G, Mayr M, Wick G, Oberhollenzer F, Willeit J, Kiechl S et al. ( 2005 ) . Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study . Stroke vol. 36 , ( 12 ) Article PMID: 16254226 , 2571 - 2576 .

Püntmann VO, Hussain MB, Mayr M, Xu Q, Singer DRJ ( 2005 ) . Role of oxidative stress in angiotensin-II mediated contraction of human conduit arteries in patients with cardiovascular disease . Vascular Pharmacology vol. 43 , ( 4 ) 277 - 282 .

Mayr U, Mayr M, Yin X, Begum S, Tarelli E, Wait R, Xu Q ( 2005 ) . Proteomic dataset of mouse aortic smooth muscle cells . Proteomics vol. 5 , ( 17 ) 4546 - 4557 .

Ali ZA, Bursill CA, Hu Y, Choudhury RP, Xu Q, Greaves DR, Channon KM ( 2005 ) . Gene Transfer of a Broad Spectrum CC-Chemokine Inhibitor Reduces Vein Graft Atherosclerosis in Apolipoprotein E–Knockout Mice . Circulation vol. 112 , ( 9_supplement ) i235 - i241 .

Mayr M, Chung Y-L, Mayr U, Yin X, Ly L, Troy H, Fredericks S, Hu Y et al. ( 2005 ) . Proteomic and Metabolomic Analyses of Atherosclerotic Vessels From Apolipoprotein E-Deficient Mice Reveal Alterations in Inflammation, Oxidative Stress, and Energy Metabolism . Arteriosclerosis Thrombosis and Vascular Biology vol. 25 , ( 10 ) 2135 - 2142 .

Foteinos G, Afzal AR, Mandal K, Jahangiri M, Xu Q ( 2005 ) . Anti–Heat Shock Protein 60 Autoantibodies Induce Atherosclerosis in Apolipoprotein E–Deficient Mice via Endothelial Damage . Circulation vol. 112 , ( 8 ) 1206 - 1213 .

Xu Q ( 2005 ) . The role of stem cells in atherosclerosis . Archives of Cardiovascular Diseases vol. 98 , ( 6 ) 672 - 676 .

Mandal K, Torsney E, Poloniecki J, Camm AJ, Xu Q, Jahangiri M ( 2005 ) . Association of High Intracellular, But Not Serum, Heat Shock Protein 70 With Postoperative Atrial Fibrillation . The Annals of Thoracic Surgery vol. 79 , ( 3 ) 865 - 871 .

Xu Q-B ( 2005 ) . Endothelial progenitor cells in angiogenesis . Acta Physiol Sinica vol. 57 , ( 1 ) 1 - 6 .

Torsney E, Hu Y, Xu Q ( 2005 ) . Adventitial Progenitor Cells Contribute to Arteriosclerosis . Trends in Cardiovascular Medicine vol. 15 , ( 2 ) 64 - 68 .

Zampetaki A, Zhang Z, Hu Y, Xu Q ( 2005 ) . Biomechanical stress induces IL-6 expression in smooth muscle cells via Ras/Rac1-p38 MAPK-NF-κB signaling pathways . AJP Heart and Circulatory Physiology vol. 288 , ( 6 ) h2946 - h2954 .

Mandal K, Jahangiri M, Xu Q ( 2005 ) . Autoimmune Mechanisms of Atherosclerosis . vol. 170 , ( 170 ) 723 - 743 .

WANG W, Yin XK, Xu QB, Wait R, Mayr U, Mayr M, Xiao QZ, Tarelli E ( 2005 ) . Proteomic dataset of Sca-1+ progenitor cells . Proteomics vol. 5 , ( 17 ) 4533 - 4545 .

Mayr M, Mayr U, Chung Y, Yin X, Griffiths JR, Xu Q ( 2004 ) . Vascular proteomics: Linking proteomic and metabolomic changes . Proteomics vol. 4 , ( 12 ) 3751 - 3761 .

Xu Q, Wick G ( 2004 ) . The Pathogenic Role of Heat Shock Proteins in Atherosclerosis . Infection and Autoimmunity, 2nd edition ,

Xu Q ( 2004 ) . Mouse Models of Vein Grafts . Arteriosclerosis Thrombosis and Vascular Biology vol. 24 , ( 11 )

Mayr M, Mandal K, Xu Q ( 2004 ) . Pitfalls of Proteomics . Circulation vol. 110 , ( 12 ) e316 - e316 .

Mayr M, Metzler B, Chung Y-L, McGregor E, Mayr U, Troy H, Hu Y, Leitges M et al. ( 2004 ) . Ischemic preconditioning exaggerates cardiac damage in PKC-δ null mice . AJP Heart and Circulatory Physiology vol. 287 , ( 2 ) h946 - h956 .

Mayr M, Chung Y-L, Mayr U, McGregor E, Troy H, Baier G, Leitges M, Dunn MJ et al. ( 2004 ) . Loss of PKC-δ alters cardiac metabolism . AJP Heart and Circulatory Physiology vol. 287 , ( 2 ) h937 - h945 .

Mandal K, Jahangiri M, Mukhin M, Poloniecki J, Camm AJ, Xu Q ( 2004 ) . Association of Anti–Heat Shock Protein 65 Antibodies With Development of Postoperative Atrial Fibrillation . Circulation vol. 110 , ( 17 ) 2588 - 2590 .

Xu Q ( 2004 ) . Mouse Models of Arteriosclerosis From Arterial Injuries to Vascular Grafts . American Journal Of Pathology vol. 165 , ( 1 ) 1 - 10 .

Schett G, Redlich K, Pietschmann P, Smolen J, Kiechl S, Willeit J, Oberhollenzer F, Weger S et al. ( 2004 ) . Soluble RANKL and Risk of Nontraumatic Fracture—Reply . JAMA vol. 291 , ( 22 ) 2703 - 2703 .

Mayr M, Siow R, Chung Y-L, Mayr U, Griffiths JR, Xu Q ( 2004 ) . Proteomic and Metabolomic Analysis of Vascular Smooth Muscle Cells . Circulation Research vol. 94 , ( 10 ) e87 - e96 .

Mayr M, Siow R, Chung Y-L, Mayr U, Griffiths JR, Xu Q ( 2004 ) . A PROTEOMIC AND METABOLOMIC ANALYSIS: ROLE OF PKCDELTA IN VASCULAR SMOOTH MUSCLE CELLS . Cardiovascular Pathology vol. 13 , ( 3 )

Hu Y, Zhang Z, Torsney E, Davison F, Xu Q ( 2004 ) . ANGIOGENESIS WITHIN ATHEROSCLEROTIC LESIONS BY STEM/PROGENITOR CELLS . Cardiovascular Pathology vol. 13 , ( 3 )

Hu Y, Zhang Z, Torsney E, Afzal AR, Davison F, Metzler B, Xu Q ( 2004 ) . Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice . Journal of Clinical Investigation vol. 113 , ( 9 ) 1258 - 1265 .

Torsney E, Hu Y, Zou Y, Xu Q ( 2004 ) . ENDOTHELIAL DAMAGE AND THROMBOSIS IN VEIN GRAFT ATHEROSCLEROSIS ARE INHIBITED BY ASPIRIN . Cardiovascular Pathology vol. 13 , ( 3 ) 177 - 178 .

Mayr M, Kiechl S, Tsimikas S, Miller E, Willeit J, Witztum JL, Xu Q ( 2004 ) . INFECTIONS, IMMUNITY AND ATHEROSCLEROSIS: ASSOCIATIONS OF ANTIBODIES TO OXIDIZED LDL AND INFECTIOUS AGENTS IN THE BRUNECK STUDY . Cardiovascular Pathology vol. 13 , ( 3 )

Torsney E, Mayr U, Zou Y, Thompson WD, Hu Y, Xu Q ( 2004 ) . Thrombosis and Neointima Formation in Vein Grafts Are Inhibited by Locally Applied Aspirin Through Endothelial Protection . Circulation Research vol. 94 , ( 11 ) 1466 - 1473 .

Wick G, Knoflach M, Xu Q ( 2004 ) . Autoimmune and Inflammatory Mechanisms in Atherosclerosis . Annual Reviews

Schett G, Kiechl S, Redlich K, Oberhollenzer F, Weger S, Egger G, Mayr A, Jocher J et al. ( 2004 ) . Soluble RANKL and Risk of Nontraumatic Fracture . JAMA vol. 291 , ( 9 ) 1108 - 1113 .

Zal B, Kaski JC, Arno G, Akiyu JP, Xu Q, Cole D, Whelan M, Russell N et al. ( 2004 ) . Heat-Shock Protein 60-Reactive CD4+CD28null T Cells in Patients With Acute Coronary Syndromes . Circulation vol. 109 , ( 10 ) 1230 - 1235 .

Mandal K, Jahangiri M, Xu Q ( 2004 ) . Autoimmunity to heat shock proteins in atherosclerosis . Autoimmunity Reviews vol. 3 , ( 2 ) 31 - 37 .

Xu Q, Wick G ( 2004 ) . 56 The Pathogenic Role of Heat Shock Proteins in Atherosclerosis . Infection and Autoimmunity , Elsevier

Hu Y, Davison F, Zhang Z, Xu Q ( 2003 ) . Endothelial Replacement and Angiogenesis in Arteriosclerotic Lesions of Allografts Are Contributed by Circulating Progenitor Cells . Circulation vol. 108 , ( 25 ) 3122 - 3127 .

Xu Q, Zhang Z, Davison F, Hu Y ( 2003 ) . Circulating Progenitor Cells Regenerate Endothelium of Vein Graft Atherosclerosis, Which Is Diminished in ApoE-Deficient Mice . Circulation Research vol. 93 , ( 8 ) e76 - e86 .

Schett G, Steiner C-W, Xu Q, Smolen JS, Steiner G ( 2003 ) . TNFα mediates susceptibility to heat-induced apoptosis by protein phosphatase-mediated inhibition of the HSF1/hsp70 stress response . Cell Death & Differentiation vol. 10 , ( 10 ) 1126 - 1136 .

Li C, Wernig F, Leitges M, Hu Y, Xu Q ( 2003 ) . Mechanical stress‐activated PKCδ regulates smooth muscle cell migration . The FASEB Journal vol. 17 , ( 14 ) 1 - 21 .

Xu Q ( 2003 ) . Infections, heat shock proteins, and atherosclerosis . Current Opinion in Cardiology vol. 18 , ( 4 )

Metzler B, Abia R, Ahmad M, Wernig F, Pachinger O, Hu Y, Xu Q ( 2003 ) . Activation of Heat Shock Transcription Factor 1 in Atherosclerosis . American Journal Of Pathology vol. 162 , ( 5 ) 1669 - 1676 .

Perschinka H, Mayr M, Millonig G, Mayerl C, van der Zee R, Morrison SG, Morrison RP, Xu Q et al. ( 2003 ) . Cross-Reactive B-Cell Epitopes of Microbial and Human Heat Shock Protein 60/65 in Atherosclerosis . Arteriosclerosis Thrombosis and Vascular Biology vol. 23 , ( 6 ) 1060 - 1065 .

Wernig F, Mayr M, Xu Q ( 2003 ) . Mechanical Stretch-Induced Apoptosis in Smooth Muscle Cells Is Mediated by &bgr;1-Integrin Signaling Pathways . Hypertension vol. 41 , ( 4 ) 903 - 911 .

Shaw A, Xu Q ( 2003 ) . Biomechanical stress-induced signaling in smooth muscle cells: an update . Current Vascular Pharmacology vol. 1 , ( 1 ) 41 - 58 .

Mayr M, Kiechl S, Mendall MA, Willeit J, Wick G, Xu Q ( 2003 ) . Increased Risk of Atherosclerosis Is Confined to CagA-Positive Helicobacter pylori Strains . Stroke vol. 34 , ( 3 ) 610 - 615 .

Schett G, Steiner C, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G ( 2002 ) . Die gegenseitige Beeinflussung von Fas‐Aktivierung und Stressproteinantwort entscheidet über Apoptose oder Resistenzentwicklung von Zellen . Wiener klinische Wochenschrift vol. 27 , ( 3 ) 94 - 98 .

Metzler B, Hammerer-Lercher A, Jehle J, Dietrich H, Pachinger O, Xu Q, Mair J ( 2002 ) . Plasma cardiac troponin T closely correlates with infarct size in a mouse model of acute myocardial infarction . Clinica Chimica Acta vol. 325 , ( 1-2 ) 87 - 90 .

Lardenoye JHP, de Vries MR, Löwik CWGM, Xu Q, Dhore CR, Cleutjens JPM, van Hinsbergh VWM, van Bockel JH et al. ( 2002 ) . Accelerated Atherosclerosis and Calcification in Vein Grafts . Circulation Research vol. 91 , ( 7 ) 577 - 584 .

Hu Y, Mayr M, Metzler B, Erdel M, Davison F, Xu Q ( 2002 ) . Both Donor and Recipient Origins of Smooth Muscle Cells in Vein Graft Atherosclerotic Lesions . Circulation Research vol. 91 , ( 7 ) e13 - e20 .

Hu Y, Davison F, Ludewig B, Erdel M, Mayr M, Url M, Dietrich H, Xu Q ( 2002 ) . Smooth Muscle Cells in Transplant Atherosclerotic Lesions Are Originated From Recipients, but Not Bone Marrow Progenitor Cells . Circulation vol. 106 , ( 14 ) 1834 - 1839 .

Kiechl S, Werner P, Egger G, Oberhollenzer F, Mayr M, Xu Q, Poewe W, Willeit J ( 2002 ) . Active and Passive Smoking, Chronic Infections, and the Risk of Carotid Atherosclerosis . Stroke vol. 33 , ( 9 ) 2170 - 2176 .

Xu Q ( 2002 ) . Role of Heat Shock Proteins in Atherosclerosis . Arteriosclerosis Thrombosis and Vascular Biology vol. 22 , ( 10 ) 1547 - 1559 .

Mayr M, Hu Y, Hainaut P, Xu Q ( 2002 ) . Mechanical Stress‐induced DNA damage and rac‐p38MAPK Signal Pathways Mediate p53‐dependent Apoptosis in Vascular Smooth Muscle Cells . The FASEB Journal vol. 16 , ( 11 ) 1423 - 1425 .

Mayr U, Mayr M, Li C, Wernig F, Dietrich H, Hu Y, Xu Q ( 2002 ) . Loss of p53 Accelerates Neointimal Lesions of Vein Bypass Grafts in Mice . Circulation Research vol. 90 , ( 2 ) 197 - 204 .

Wernig F, Xu Q ( 2002 ) . Mechanical stress-induced apoptosis in the cardiovascular system . Progress in Biophysics and Molecular Biology vol. 78 , ( 2-3 ) 105 - 137 .

Hu Y, Xu Q ( 2002 ) . New mouse model of vein bypass graft atherosclerosis . Heart Lung and Circulation vol. 11 , ( 3 ) 182 - 188 .

Xu Q ( 2001 ) . Heat shock proteins and atherosclerosis . European Journal of Clinical Investigation vol. 31 , ( 4 ) 283 - 284 .

Metzler B, Mayr M, Dietrich H, Singh M, Wiebe E, Xu Q, Wick G ( 2001 ) . Erratum: Inhibition of arteriosclerosis by T-cell depletion in normocholesterolemic rabbits immunized with heat shock protein 65 (Arteriosclerosis, Thrombosis and Vascular Biology (1998) 19 (1905-1911)) . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 21 , ( 10 )

Leitges M, Mayr M, Braun U, Mayr U, Li C, Pfister G, Ghaffari-Tabrizi N, Baier G et al. ( 2001 ) . Exacerbated vein graft arteriosclerosis in protein kinase Cδ–null mice . Journal of Clinical Investigation vol. 108 , ( 10 ) 1505 - 1512 .

Dunzendorfer S, Meierhofer C, Xu Q, Wiedermann CJ ( 2001 ) . Pentoxifylline‐augmented antiproliferative effects of adrenomedullin on vascular smooth muscle cells . European Journal of Heart Failure vol. 2 , ( 3 ) 257 - 260 .

Hu Y, Baker AH, Zou Y, Newby AC, Xu Q ( 2001 ) . Local Gene Transfer of Tissue Inhibitor of Metalloproteinase-2 Influences Vein Graft Remodeling in a Mouse Model . Arteriosclerosis Thrombosis and Vascular Biology vol. 21 , ( 8 ) 1275 - 1280 .

Mayr M, Xu Q ( 2001 ) . Smooth muscle cell apoptosis in arteriosclerosis . Experimental Gerontology vol. 36 , ( 7 ) 969 - 987 .

Schett G, Hayer S, Tohidast-Akrad M, Xu Q, Kollias G, Steiner G, Smolen J ( 2001 ) . FRI0074 Adenoviral-based overexpression of timp-1 reduces tissue damage in the joints of tnf-a-transgenic mice . Conference: Speaker abstracts 2001a476.1 - a4a476 .

Schett G, Hayer S, Tohidast-Akrad M, Jahn-Schmid B, Lang S, Kainberger F, Kollias G, Newby A et al. ( 2001 ) . Adenoviral-based overexpression of TIMP-1 reduces tissue damage in the joints of TNF-alpha transgenic mice . Arthritis Research & Therapy vol. 3 , ( Suppl 1 )

Kiechl S, Egger G, Mayr M, Wiedermann CJ, Bonora E, Oberhollenzer F, Muggeo M, Xu Q et al. ( 2001 ) . Chronic Infections and the Risk of Carotid Atherosclerosis . Circulation vol. 103 , ( 8 ) 1064 - 1070 .

Metzler B, Mair J, Lercher A, Schaber C, Hintringer F, Pachinger O, Xu Q ( 2001 ) . Mouse model of myocardial remodelling after ischemia: role of intercellular adhesion molecule-1 . Cardiovascular Research vol. 49 , ( 2 ) 399 - 407 .

Schett G, Hayer S, Xu Q, Tohidast-Akrad M, Kollias G, Steiner G, Smolen J ( 2001 ) . Adenoviral-based overexpression of TIMP-1 reduces tissue damage in the joints TNF-transgenic mice . Arthritis Research & Therapy vol. 3 , ( Suppl 2 )

Schett G, Tohidast‐Akrad M, Smolen JS, Schmid BJ, Steiner C, Bitzan P, Zenz P, Redlich K et al. ( 2001 ) . Activation, differential localization, and regulation of the stress‐activated protein kinases, extracellular signal–regulated kinase, c‐Jun N‐terminal kinase, and p38 mitogen‐activated protein kinase, in synovial tissue and cells in rheumatoid arthritis . Arthritis & Rheumatism vol. 43 , ( 11 ) 2501 - 2512 .

Schett G, Hayer S, Tohidast‐Akrad M, Schmid BJ, Lang S, Türk B, Kainberger F, Haralambous S et al. ( 2001 ) . Adenovirus‐based overexpression of tissue inhibitor of metalloproteinases 1 reduces tissue damage in the joints of tumor necrosis factor α transgenic mice . Arthritis & Rheumatism vol. 44 , ( 12 ) 2888 - 2898 .

Wick G, Millonig G, Xu Q ( 2001 ) . The Autoimmune Pathogenesis of Atherosclerosis—An Evolutionary-Darwinian Concept . Atherosclerosis and Autoimmunity , Elsevier

Mayr M, Kiechl S, Willeit J, Wick G, Xu Q ( 2000 ) . Infections, Immunity, and Atherosclerosis . Circulation vol. 102 , ( 8 ) 833 - 839 .

Dietrich H, Hu Y, Zou Y, Huemer U, Metzler B, Li C, Mayr M, Xu Q ( 2000 ) . Rapid Development of Vein Graft Atheroma in ApoE-Deficient Mice . American Journal Of Pathology vol. 157 , ( 2 ) 659 - 669 .

Xu Q, Schett G, Perschinka H, Mayr M, Egger G, Oberhollenzer F, Willeit J, Kiechl S et al. ( 2000 ) . Serum Soluble Heat Shock Protein 60 Is Elevated in Subjects With Atherosclerosis in a General Population . Circulation vol. 102 , ( 1 ) 14 - 20 .

Hu Y, Li C, Sturm G, Wick G, Xu Q ( 2000 ) . Mechanical stress-induced HSP70 expression in SMC via RAS/RAC G-proteins, but not MAPK . Atherosclerosis vol. 151 , ( 1 )

Li C, Xu Q ( 2000 ) . Mechanical stress-initiated signal transductions in vascular smooth muscle cells . Cellular Signalling vol. 12 , ( 7 ) 435 - 445 .

Hu Y, Dietrich H, Zou Y, Wick G, Xu Q ( 2000 ) . Mouse model of transplant arteriosclerosis: Role of ICAM-1 . Atherosclerosis vol. 151 , ( 1 )

Hu Y, Dietrich H, Zou Y, Huemer U, Li C, Mayr M, Xu Q ( 2000 ) . Rapid development of vein graft atheroma in apoe-deficient mice: Implication for gene transfer study . Atherosclerosis vol. 151 , ( 1 )

Xu Q, Schett G, Li C, Hu Y, Wick G ( 2000 ) . Mechanical Stress–Induced Heat Shock Protein 70 Expression in Vascular Smooth Muscle Cells Is Regulated by Rac and Ras Small G Proteins but Not Mitogen-Activated Protein Kinases . Circulation Research vol. 86 , ( 11 ) 1122 - 1128 .

Metzler B, Hu Y, Dietrich H, Xu Q ( 2000 ) . Increased Expression and Activation of Stress-Activated Protein Kinases/c-Jun NH2-Terminal Protein Kinases in Atherosclerotic Lesions Coincide with p53 . American Journal Of Pathology vol. 156 , ( 6 ) 1875 - 1886 .

Hu Y, Zou Y, Hala M, Dietrich H, Wick G, Xu Q ( 2000 ) . PROLONGED SURVIVAL OF HEART ALLOGRAFTS FROM p53-DEFICIENT MICE1 . Transplantation vol. 69 , ( 12 ) 2634 - 2640 .

Kiechl S, Willeit J, Bonora E, Schwarz S, Xu Q ( 2000 ) . No Association Between Dehydroepiandrosterone Sulfate and Development of Atherosclerosis in a Prospective Population Study (Bruneck Study) . Arteriosclerosis Thrombosis and Vascular Biology vol. 20 , ( 4 ) 1094 - 1100 .

Zou Y, Hu Y, Mayr M, Dietrich H, Wick G, Xu Q ( 2000 ) . Reduced Neointima Hyperplasia of Vein Bypass Grafts in Intercellular Adhesion Molecule-1–Deficient Mice . Circulation Research vol. 86 , ( 4 ) 434 - 440 .

Hochleitner B-W, Hochleitner E-O, Obrist P, Eberl T, Amberger A, Xu Q, Margreiter R, Wick G ( 2000 ) . Fluid Shear Stress Induces Heat Shock Protein 60 Expression in Endothelial Cells In Vitro and In Vivo . Arteriosclerosis Thrombosis and Vascular Biology vol. 20 , ( 3 ) 617 - 623 .

Li C, Hu Y, Sturm G, Wick G, Xu Q ( 2000 ) . Ras/Rac-Dependent Activation of p38 Mitogen-Activated Protein Kinases in Smooth Muscle Cells Stimulated by Cyclic Strain Stress . Arteriosclerosis Thrombosis and Vascular Biology vol. 20 , ( 3 ) e1 - e9 .

Mayr M, Li C, Zou Y, Huemer U, Hu Y, Xu Q ( 2000 ) . Biomechanical stress‐induced apoptosis in vein grafts involves p38 mitogen‐activated protein kinases . The FASEB Journal vol. 14 , ( 2 ) 261 - 270 .

Dietrich H, Hu Y, Zou Y, Dirnhofer S, Kleindienst R, Wick G, Xu Q ( 2000 ) . Mouse Model of Transplant Arteriosclerosis . Arteriosclerosis Thrombosis and Vascular Biology vol. 20 , ( 2 ) 343 - 352 .

Xu Q ( 2000 ) . Biomechanical-stress-induced Signaling and Gene Expression in the Development of Arteriosclerosis . Trends in Cardiovascular Medicine vol. 10 , ( 1 ) 35 - 41 .

Hu Y, Dietrich H, Metzler B, Wick G, Xu Q ( 2000 ) . Hyperexpression and Activation of Extracellular Signal–Regulated Kinases (ERK1/2) in Atherosclerotic Lesions of Cholesterol-Fed Rabbits . Arteriosclerosis Thrombosis and Vascular Biology vol. 20 , ( 1 ) 18 - 26 .

Mayr M, Xu Q, Wick G ( 1999 ) . Atherogenic effects of chronic infections: the role of heat shock protein 60 in autoimmunity . Israel Medical Association Journal vol. 1 , ( 4 ) 272 - 277 .

Wick G, Perschinka H, Xu Q ( 1999 ) . Autoimmunity and atherosclerosis . American Heart Journal . vol. 138 , s444 - s449 .

Xu Q, Kiechl S, Mayr M, Metzler B, Egger G, Oberhollenzer F, Willeit J, Wick G ( 1999 ) . Association of Serum Antibodies to Heat-Shock Protein 65 With Carotid Atherosclerosis . Circulation vol. 100 , ( 11 ) 1169 - 1174 .

Li C, Hu Y, Mayr M, Xu Q ( 1999 ) . Cyclic Strain Stress-induced Mitogen-activated Protein Kinase (MAPK) Phosphatase 1 Expression in Vascular Smooth Muscle Cells Is Regulated by Ras/Rac-MAPK Pathways* . Journal of Biological Chemistry vol. 274 , ( 36 ) 25273 - 25280 .

Hu Y, Zou Y, Dietrich H, Wick G, Xu Q ( 1999 ) . Inhibition of Neointima Hyperplasia of Mouse Vein Grafts by Locally Applied Suramin . Circulation vol. 100 , ( 8 ) 861 - 868 .

Wick G, Xu Q ( 1999 ) . Atherosclerosis—An autoimmune disease! 11This paper is a modified version of an informal article that appeared in the February 1999 issue of Immunology News of the British Society for Immunology . Experimental Gerontology vol. 34 , ( 4 ) 559 - 566 .

Metzler B, Mayr M, Dietrich H, Singh M, Wiebe E, Xu Q, Wick G ( 1999 ) . Inhibition of Arteriosclerosis by T-Cell Depletion in Normocholesterolemic Rabbits Immunized With Heat Shock Protein 65 . Arteriosclerosis Thrombosis and Vascular Biology vol. 19 , ( 8 ) 1905 - 1911 .

Metzler B, Li C, Hu Y, Sturm G, Ghaffari-Tabrizi N, Xu Q ( 1999 ) . LDL Stimulates Mitogen-Activated Protein Kinase Phosphatase-1 Expression, Independent of LDL Receptors, in Vascular Smooth Muscle Cells . Arteriosclerosis Thrombosis and Vascular Biology vol. 19 , ( 8 ) 1862 - 1871 .

Schett G, Metzler B, Kleindienst R, Amberger A, Recheis H, Xu Q, Wick G ( 1999 ) . Myocardial injury leads to a release of heat shock protein (hsp) 60 and a suppression of the anti-hsp65 immune response . Cardiovascular Research vol. 42 , ( 3 ) 685 - 695 .

Schett G, Steiner C-W, Gröger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G ( 1999 ) . Activation of Fas inhibits heat‐induced activation of HSF1 and up‐regulation of hsp70 . The FASEB Journal vol. 13 , ( 8 ) 833 - 842 .

Mayr M, Metzler B, Kiechl S, Willeit J, Schett G, Xu Q, Wick G ( 1999 ) . Endothelial Cytotoxicity Mediated by Serum Antibodies to Heat Shock Proteins of Escherichia coli and Chlamydia pneumoniae . Circulation vol. 99 , ( 12 ) 1560 - 1566 .

Amberger A, Hala M, Saurwein-Teissl M, Metzler B, Grubeck-Loebenstein B, Xu Q, Wick G ( 1999 ) . Suppressive Effects of Anti-inflammatory Agents on Human Endothelial Cell Activation and Induction of Heat Shock Proteins . Molecular Medicine vol. 5 , ( 2 ) 117 - 128 .

Metzler B, Hu Y, Sturm G, Wick G, Xu Q ( 1998 ) . Induction of Mitogen-activated Protein Kinase Phosphatase-1 by Arachidonic Acid in Vascular Smooth Muscle Cells* . Journal of Biological Chemistry vol. 273 , ( 50 ) 33320 - 33326 .

Zou Y, Dietrich H, Hu Y, Metzler B, Wick G, Xu Q ( 1998 ) . Mouse Model of Venous Bypass Graft Arteriosclerosis . American Journal Of Pathology vol. 153 , ( 4 ) 1301 - 1310 .

Melrose J, Whitelock J, Xu Q, Ghosh P ( 1998 ) . Pathogenesis of abdominal aortic aneurysms: Possible role of differential production of proteoglycans by smooth muscle cells . Journal of Vascular Surgery vol. 28 , ( 4 ) 676 - 686 .

Hu Y, Böck G, Wick G, Xu Q ( 1998 ) . Activation of PDGF receptor α in vascular smooth muscle cells by mechanical stress . The FASEB Journal vol. 12 , ( 12 ) 1135 - 1142 .

Hu Y, Hochleitner B-W, Wick G, Xu Q ( 1998 ) . Decline of shear stress-induced activation of extracellular signal-regulated kinases, but not stress-activated protein kinases, in in vitro propagated endothelial cells . Experimental Gerontology vol. 33 , ( 6 ) 601 - 613 .

Schett G, Redlich K, Xu Q, Bizan P, Gröger M, Tohidast-Akrad M, Kiener H, Smolen J et al. ( 1998 ) . Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs . Journal of Clinical Investigation vol. 102 , ( 2 ) 302 - 311 .

Metzler B, Xu Q, Wick G ( 1998 ) . The role of (auto-) immunity in atherogenesis . Wiener klinische Wochenschrift vol. 110 , ( 10 ) 350 - 355 .

Zou Y, Hu Y, Metzler B, Xu Q ( 1998 ) . Signal transduction in arteriosclerosis: mechanical stress-activated MAP kinases in vascular smooth muscle cells (review) . International Journal of Molecular Medicine vol. 1 , ( 5 ) 827 - 834 .

Hu Y, Schett G, Zou Y, Dietrich H, Xu Q ( 1998 ) . Abundance of platelet-derived growth factors (PDGFs), PDGF receptors and activation of mitogen-activated protein kinases in brain decline with age . Brain Research vol. 53 , ( 1-2 ) 251 - 258 .

Hu Y, Cheng L, Hochleitner B-W, Xu Q ( 1997 ) . Activation of Mitogen-Activated Protein Kinases (ERK/JNK) and AP-1 Transcription Factor in Rat Carotid Arteries After Balloon Injury . Arteriosclerosis Thrombosis and Vascular Biology vol. 17 , ( 11 ) 2808 - 2816 .

Wick G, Romen M, Amberger A, Metzler B, Mayr M, Falkensammer G, Xu Q ( 1997 ) . Atherosclerosis, autoimmunity, and vascular‐associated lymphoid tissue . The FASEB Journal vol. 11 , ( 13 ) 1199 - 1207 .

Hu Y, Cheng L, Hochleitner B-W, Xu Q ( 1997 ) . 3.P.211 Activation of mitogen-activated protein kinases and activator protein-1 in rat arteries after balloon injury . Atherosclerosis vol. 134 , ( 1-2 )

Hu Y, Hochleitner B-W, Wick G, Xu Q ( 1997 ) . 3.P.317 Age-related decline in activation of mitogen-activated protein kinases in shear-stressed endothelial cells . Atherosclerosis vol. 134 , ( 1-2 )

Xu Q, Hu Y, Kleindienst R, Wick G ( 1997 ) . Nitric oxide induces heat-shock protein 70 expression in vascular smooth muscle cells via activation of heat shock factor 1 . Journal of Clinical Investigation vol. 100 , ( 5 ) 1089 - 1097 .

Xu Q, Fawcett TW, Gorospe M, Guyton KZ, Liu Y, Holbrook NJ ( 1997 ) . Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension . Hypertension vol. 30 , ( 1 Pt 1 ) 106 - 111 .

Hu Y, Metzler B, Xu Q ( 1997 ) . Discordant Activation of Stress-activated Protein Kinases or c-Jun NH2-terminal Protein Kinases in Tissues of Heat-stressed Mice* . Journal of Biological Chemistry vol. 272 , ( 14 ) 9113 - 9119 .

Metzler B, Schett G, Kleindienst R, van der Zee R, Ottenhoff T, Hajeer A, Bernstein R, Xu Q et al. ( 1997 ) . Epitope specificity of anti-heat shock protein 65/60 serum antibodies in atherosclerosis . Arteriosclerosis Thrombosis and Vascular Biology vol. 17 , ( 3 ) 536 - 541 .

Amberger A, Maczek C, Jürgens G, Michaelis D, Schett G, Trieb K, Eberl T, Jindal S et al. ( 1997 ) . Co-expression of ICAM-1, VCAM-1, ELAM-1 and Hsp60 in human arterial and venous endothelial cells in response to cytokines and oxidized low-density lipoproteins . Cell Stress and Chaperones vol. 2 , ( 2 ) 94 - 103 .

Schett G, Metzler B, Mayr M, Amberger A, Niederwieser D, Gupta RS, Mizzen L, Xu Q et al. ( 1997 ) . Macrophage-lysis mediated by autoantibodies to heat shock protein 65/60 . Atherosclerosis vol. 128 , ( 1 ) 27 - 38 .

Fawcett TW, Xu Q, Holbrook NJ ( 1997 ) . Potentiation of heat stress-induced hsp70 expression in vivo by aspirin . Cell Stress and Chaperones vol. 2 , ( 2 ) 104 - 109 .

Schett G, Metzler B, Amberger A, Michaelis D, Romen M, Xu Q, Wick G ( 1997 ) . The Influence of Heat Shock Proteins in Atherogenesis . Heat Shock Proteins and the Cardiovascular System , vol. 192 , Springer Nature

Xu Q, Wick G ( 1996 ) . The role of heat shock proteins in protection and pathophysiology of the arterial wall . Trends in Molecular Medicine vol. 2 , ( 9 ) 372 - 379 .

Xu Q, Fawcett TW, Udelsman R, Holbrook NJ ( 1996 ) . Activation of heat shock transcription factor 1 in rat aorta in response to high blood pressure . Hypertension vol. 28 , ( 1 ) 53 - 57 .

Xu Q, Kleindienst R, Schett G, Waitz W, Jindal S, Gupta RS, Dietrich H, Wick G ( 1996 ) . Regression of arteriosclerotic lesions induced by immunization with heat shock protein 65-containing material in normocholesterolemic, but not hypercholesterolemic, rabbits . Atherosclerosis vol. 123 , ( 1-2 ) 145 - 155 .

GUYTON KZ, XU Q, HOLBROOK NJ ( 1996 ) . Induction of the mammalian stress response gene GADD153 by oxidative stress: role of AP-1 element . Biochemical Journal vol. 314 , ( 2 ) 547 - 554 .

Guyton KZ, Liu Y, Gorospe M, Xu Q, Holbrook NJ ( 1996 ) . Activation of Mitogen-activated Protein Kinase by H2O2 ROLE IN CELL SURVIVAL FOLLOWING OXIDANT INJURY (∗) . Journal of Biological Chemistry vol. 271 , ( 8 ) 4138 - 4142 .

Liu Y, Guyton KZ, Gorospe M, Xu Q, Holbrook NJ, Kokkonen GC, Mock YD, Roth GS ( 1996 ) . Age-related Decline in Mitogen-activated Protein Kinase Activity in Epidermal Growth Factor-stimulated Rat Hepatocytes (∗) . Journal of Biological Chemistry vol. 271 , ( 7 ) 3604 - 3607 .

Xu Q, Liu Y, Gorospe M, Udelsman R, Holbrook NJ ( 1996 ) . Acute hypertension activates mitogen-activated protein kinases in arterial wall . Journal of Clinical Investigation vol. 97 , ( 2 ) 508 - 514 .

Seitz CS, Kleindienst R, Xu Q, Wick G ( 1996 ) . Coexpression of heat-shock protein 60 and intercellular-adhesion molecule-1 is related to increased adhesion of monocytes and T cells to aortic endothelium of rats in response to endotoxin . Laboratory Investigation vol. 74 , ( 1 ) 241 - 252 .

Liu Y, Guyton KZ, Gorospe M, Xu Q, Lee JC, Holbrook NJ ( 1996 ) . Differential activation of ERK, JNK/SAPK and P3/CSBP/RK map kinase family members during the cellular response to arsenite . Free Radical Biology and Medicine vol. 21 , ( 6 ) 771 - 781 .

Xu Q, Ganju L, Fawcett TW, Holbrook NJ ( 1996 ) . Vasopressin-induced heat shock protein expression in renal tubular cells . Laboratory Investigation vol. 74 , ( 1 ) 178 - 187 .

Schett G, Xu Q, Amberger A, Van der Zee R, Recheis H, Willeit J, Wick G ( 1995 ) . Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity . Journal of Clinical Investigation vol. 96 , ( 6 ) 2569 - 2577 .

Kleindienst R, Schett G, Amberger A, Seitz CS, Michaelis D, Metzler B, Dietrich H, Xu Q et al. ( 1995 ) . Atherosclerosis as an autoimmune condition . Israel Medical Association Journal vol. 31 , ( 10 ) 596 - 599 .

Xu Q, Li DG, Holbrook NJ, Udelsman R ( 1995 ) . Acute hypertension induces heat-shock protein 70 gene expression in rat aorta . Circulation vol. 92 , ( 5 ) 1223 - 1229 .

Kleindienst R, Xu Q, Schett G, Dietrich H, Wick G ( 1995 ) . Heat — Shock protein 65 — But not cholesterol-induced arteriosclerotic lesions regress in rabbit aortae . Atherosclerosis vol. 115 ,

Wick G, Schett G, Amberger A, Kleindienst R, Xu Q ( 1995 ) . Is atherosclerosis an immunologically mediated disease? . Trends in Immunology vol. 16 , ( 1 ) 27 - 33 .

Xu Q, Schett G, Seitz CS, Hu Y, Gupta RS, Wick G ( 1994 ) . Surface staining and cytotoxic activity of heat-shock protein 60 antibody in stressed aortic endothelial cells . Circulation Research vol. 75 , ( 6 ) 1078 - 1085 .

Xu Q, Luef G, Weimann S, Gupta RS, Wolf H, Wick G ( 1993 ) . Staining of endothelial cells and macrophages in atherosclerotic lesions with human heat-shock protein-reactive antisera . Arteriosclerosis Thrombosis and Vascular Biology vol. 13 , ( 12 ) 1763 - 1769 .

Kleindienst R, Xu Q, Willeit J, Waldenberger FR, Weimann S, Wick G ( 1993 ) . Immunology of atherosclerosis. Demonstration of heat shock protein 60 expression and T lymphocytes bearing alpha/beta or gamma/delta receptor in human atherosclerotic lesions . American Journal Of Pathology vol. 142 , ( 6 ) 1927 - 1937 .

Xu Q, Kleindienst R, Waitz W, Dietrich H, Wick G ( 1993 ) . Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65 . Journal of Clinical Investigation vol. 91 , ( 6 ) 2693 - 2702 .

Xu Q, Wick G, Willeit J, Marosi M, Kiechl S, Luef G, Kleindienst R, Stulnig T et al. ( 1993 ) . Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis . The Lancet vol. 341 , ( 8840 ) 255 - 259 .

Xu Q, Bühler E, Steinmetz A, Schönitzer D, Böck G, Jürgens G, Wick G ( 1992 ) . A high-density-lipoprotein receptor appears to mediate the transfer of essential fatty acids from high-density lipoprotein to lymphocytes . Biochemical Journal vol. 287 , ( 2 ) 395 - 401 .

Xu Q, Dietrich H, Steiner HJ, Gown AM, Schoel B, Mikuz G, Kaufmann SH, Wick G ( 1992 ) . Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65 . Arteriosclerosis Thrombosis and Vascular Biology vol. 12 , ( 7 ) 789 - 799 .

Xu Q, Jürgens G, Huber LA, Böck G, Wolf H, Wick G ( 1992 ) . Lipid utilization by human lymphocytes is correlated with high-density-lipoprotein binding site activity . Biochemical Journal vol. 285 , ( 1 ) 105 - 112 .

Wick G, Kleindienst R, Dietrich H, Xu Q ( 1992 ) . Is atherosclerosis an autoimmune disease? . Trends in Food Science & Technology vol. 3 , 114 - 119 .

Xu Q, Oberhuber G, Gruschwitz M, Wick G ( 1990 ) . Immunology of atherosclerosis: Cellular composition and major histocompatibility complex class II antigen expression in aortic intima, fatty streaks, and atherosclerotic plaques in young and aged human specimens . Clinical Immunology vol. 56 , ( 3 ) 344 - 359 .

Jürgens G, Xu QB, Huber LA, Böck G, Howanietz H, Wick G, Traill KN ( 1989 ) . Promotion of Lymphocyte Growth by High Density Lipoproteins (HDL) Physiological Significance of the HDL Binding Site . Journal of Biological Chemistry vol. 264 , ( 15 ) 8549 - 8556 .