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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Roberto Bellelli

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Hill BR, Ozgencil M, Buckley-Benbow L, Skingsley SLP, Tomlinson D, Eizmendi CO, Agnarelli A, Bellelli R ( 2024 ) . Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors . Cell Reports vol. 43 , ( 5 )
Ozgencil M, Dullovi A, Christiane Higos RC, Hořejší Z, Bellelli R ( 2023 ) . The linker histone H1–BRCA1 axis is a crucial mediator of replication fork stability . Life Science Alliance vol. 6 , ( 9 )
Belan O, Sebald M, Adamowicz M, Anand R, Vancevska A, Neves J, Grinkevich V, Hewitt G et al. ( 2022 ) . POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells . Molecular Cell vol. 82 , ( 24 ) 4664 - 4680.e9 .
Federico G, Carrillo F, Dapporto F, Chiariello M, Santoro M, Bellelli R, Carlomagno F ( 2022 ) . NCOA4 links iron bioavailability to DNA metabolism . Cell Reports . vol. 40 ,
Borel V, Boeing S, Van Wietmarschen N, Sridharan S, Hill BR, Ombrato L, Perez-Lloret J, Jackson D et al. ( 2022 ) . Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis . Cell Reports vol. 39 , ( 9 )
Cvetkovic MA, Ortega E, Bellelli R, Costa A ( 2022 ) . Multiple roles of Pol epsilon in eukaryotic chromosome replication . Biochemical Society Transactions vol. 50 , ( 1 ) 309 - 320 .
Venkatesan S, Angelova M, Puttick C, Zhai H, Caswell DR, Lu W-T, Dietzen M, Galanos P et al. ( 2021 ) . Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution . Cancer Discovery vol. 11 , ( 10 ) 2456 - 2473 .
Kotsantis P, Segura-Bayona S, Margalef P, Marzec P, Ruis P, Hewitt G, Bellelli R, Patel H et al. ( 2020 ) . RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions . Cell Reports vol. 33 , ( 12 )
Hewitt G, Borel V, Segura-Bayona S, Takaki T, Ruis P, Bellelli R, Lehmann LC, Sommerova L et al. ( 2020 ) . Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD . Molecular Cell vol. 81 , ( 4 ) 767 - 783.e11 .
Bellelli R, Boulton SJ ( 2020 ) . Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases . Trends in Genetics
Bellelli R, Youds J, Borel V, Svendsen J, Pavicic-Kaltenbrunner V, Boulton SJ ( 2020 ) . Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication . Cell Reports vol. 31 , ( 8 )
Logan CV, Murray JE, Parry DA, Robertson A, Bellelli R, Tarnauskaitė Ž, Challis R, Cleal L et al. ( 2018 ) . DNA Polymerase Epsilon Deficiency Causes IMAGe Syndrome with Variable Immunodeficiency . American Journal of Human Genetics vol. 103 , ( 6 ) 1038 - 1044 .
Bellelli R, Belan O, Pye VE, Clement C, Maslen SL, Skehel JM, Cherepanov P, Almouzni G et al. ( 2018 ) . POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication . Molecular Cell vol. 72 , ( 1 ) 112 - 126.e5 .
Bellelli R, Borel V, Logan C, Svendsen J, Cox DE, Nye E, Metcalfe K, O’Connell SM et al. ( 2018 ) . Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis . Molecular Cell vol. 70 , ( 4 ) 707 - 721.e7 .
Margalef P, Kotsantis P, Borel V, Bellelli R, Panier S, Boulton SJ ( 2017 ) . Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe . Cell vol. 172 , ( 3 ) 439 - 453.e14 .
Stingele J, Bellelli R, Boulton SJ ( 2017 ) . Mechanisms of DNA–protein crosslink repair . Nature Reviews Molecular Cell Biology vol. 18 , ( 9 ) 563 - 573 .
Bellelli R, Vitagliano D, Federico G, Marotta P, Tamburrino A, Salerno P, Paciello O, Papparella S et al. ( 2017 ) . Oncogene-induced senescence and its evasion in a mouse model of thyroid neoplasia . Molecular and Cellular Endocrinology vol. 460 , 24 - 35 .
Stingele J, Bellelli R, Alte F, Hewitt G, Sarek G, Maslen SL, Tsutakawa SE, Borg A et al. ( 2016 ) . Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN . Molecular Cell vol. 64 , ( 4 ) 688 - 703 .
Bellelli R, Federico G, Matte’ A, Colecchia D, Iolascon A, Chiariello M, Santoro M, De Franceschi L et al. ( 2016 ) . NCOA4 Deficiency Impairs Systemic Iron Homeostasis . Cell Reports vol. 14 , ( 3 ) 411 - 421 .
Bellelli R, Castellone MD, Guida T, Limongello R, Dathan NA, Merolla F, Cirafici AM, Affuso A et al. ( 2014 ) . NCOA4 Transcriptional Coactivator Inhibits Activation of DNA Replication Origins . Molecular Cell vol. 55 , ( 1 ) 123 - 137 .
Castellone MD, Laukkanen MO, Teramoto H, Bellelli R, Alì G, Fontanini G, Santoro M, Gutkind JS ( 2014 ) . Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma . Oncogene vol. 34 , ( 13 ) 1679 - 1687 .
Castellone MD, Langella A, Cantara S, Laurila JP, Laatikainen LE, Bellelli R, Pacini F, Salvatore M et al. ( 2014 ) . Extracellular Superoxide Dismutase Induces Mouse Embryonic Fibroblast Proliferative Burst, Growth Arrest, Immortalization, and Consequent In Vivo Tumorigenesis . Antioxidants & Redox Signaling vol. 21 , ( 10 ) 1460 - 1474 .
Bellelli R, Castellone MD, Garcia-Rostan G, Ugolini C, Nucera C, Sadow PM, Nappi TC, Salerno P et al. ( 2012 ) . FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma . Endocrine Related Cancer vol. 19 , ( 5 ) 695 - 710 .
Faraonio R, Salerno P, Passaro F, Sedia C, Iaccio A, Bellelli R, Nappi TC, Comegna M et al. ( 2011 ) . A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts . Cell Death & Differentiation vol. 19 , ( 4 ) 713 - 721 .
Castellone MD, De Falco V, Rao DM, Bellelli R, Muthu M, Basolo F, Fusco A, Gutkind JS et al. ( 2009 ) . The β-Catenin Axis Integrates Multiple Signals Downstream from RET/Papillary Thyroid Carcinoma Leading to Cell Proliferation . Cancer Research vol. 69 , ( 5 ) 1867 - 1876 .
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