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Publications:  Dr Emma Chambers

Chambers ES, Vukmanovic-Stejic M(2020). Skin barrier immunity and ageing. Immunology vol. 160, (2) 116-125.
Chambers ES, Akbar AN(2020). Can blocking inflammation enhance immunity during aging?. Journal of Allergy and Clinical Immunology vol. 145, (5) 1323-1331.
Pereira B, De Maeyer R, Covre L, Nehar-Belaid D, Lanna A, Ward S, Marches R, Chambers E et al.(2020). Sestrins induce natural killer function in 1 senescent-like CD8+ T cells. Nature Immunology
Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ et al.(2019). Senescent cells evade immune clearance via HLA-E-mediated NK and CD8<sup>+</sup> T cell inhibition. Nature Communications vol. 10, (1)
Patel NP, Vukmanovic-Stejic M, Suarez-Farinas M, Chambers ES, Sandhu D, Fuentes-Duculan J, Mabbott NA, Rustin MHA et al.(2018). Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen-Specific Challenge. J Infect Dis vol. 218, (suppl_2) S88-S98.
Vukmanovic-Stejic M, Chambers ES, Suárez-Fariñas M, Sandhu D, Fuentes-Duculan J, Patel N, Agius E, Lacy KE et al.(2018). Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammation. Journal of Allergy and Clinical Immunology vol. 142, (3) 844-856.
Covre LP, Martins RF, Devine OP, Chambers ES, Vukmanovic-Stejic M, Silva JA, Dietze R, Rodrigues RR et al.(2018). Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis. Front Immunol vol. 9,
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Martineau AR, Griffiths CJ, Corrigan CJ, Hawrylowicz CM(2018). Dendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids. Clinical and Experimental Allergy vol. 48, (1) 13-22.
Callender LA, carroll EC, beal R, Chambers ES, Nourshargh S, Akbar AN, Henson SM(2017). Human CD8+ EMRA T cells display a senescent-associated secretory phenotype regulated by p38 MAPK. Aging Cell
Mann EH, Chambers ES, Chen Y-H, Richards DF, Hawrylowicz CM(2015). 1α,25-dihydroxyvitamin D3 acts via transforming growth factor-β to up-regulate expression of immunosuppressive CD73 on human CD4+ Foxp3- T cells. Immunology vol. 146, (3) 423-431.
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ et al.(2015). Distinct endotypes of steroid-resistant asthma characterized by IL-17A<sup>high</sup> and IFN-γ<sup>high</sup> immunophenotypes: Potential benefits of calcitriol. Journal of Allergy and Clinical Immunology vol. 136, (3) 628-637.e4.
Pfeffer PE, Mann EH, Hornsby E, Chambers ES, Chen YH, Rice L, Hawrylowicz CM(2014). Vitamin D influences asthmatic pathology through its action on diverse immunological pathways. Annals of the American Thoracic Society vol. 11, S314-S321.
Chambers ES, Suwannasaen D, Mann EH, Urry Z, Richards DF, Lertmemongkolchai G, Hawrylowicz CM(2014). 1α,25-dihydroxyvitamin D3 in combination with transforming growth factor-β increases the frequency of Foxp3⁺ regulatory T cells through preferential expansion and usage of interleukin-2. Immunology vol. 143, (1) 52-60.
Gupta A, Dimeloe S, Richards DF, Chambers ES, Black C, Urry Z, Ryanna K, Xystrakis E et al.(2014). Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma. Thorax vol. 69, (6) 508-515.
Mann EH, Chambers ES, Pfeffer PE, Hawrylowicz CM(2014). Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma. Annals of the New York Academy of Sciences vol. 1317, (1) 57-69.
Nanzer AM, Chambers ES, Ryanna K, Freeman AT, Colligan G, Richards DF, Timms PM, Martineau AR et al.(2014). The effects of calcitriol treatment in glucocorticoid-resistant asthma. Journal of Allergy and Clinical Immunology
Nanzer AM, Chambers ES, Ryanna K, Richards DF, Black C, Timms PM, Martineau AR, Griffiths CJ et al.(2013). Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion. Journal of Allergy and Clinical Immunology vol. 132, (2)
Urry Z, Chambers ES, Xystrakis E, Dimeloe S, Richards DF, Gabryšová L, Christensen J, Gupta A et al.(2012). The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells. Eur J Immunol vol. 42, (10) 2697-2708.
Chambers ES, Nanzer AM, Richards DF, Ryanna K, Freeman AT, Timms PM, Martineau AR, Griffiths CJ et al.(2012). Serum 25-dihydroxyvitamin D levels correlate with CD4(+)Foxp3(+) T-cell numbers in moderate/severe asthma. J Allergy Clin Immunol vol. 130, (2) 542-544.
Chambers ES, Hawrylowicz CM(2011). The impact of vitamin D on regulatory T cells. Curr Allergy Asthma Rep vol. 11, (1) 29-36.
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