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Research

Publications: Dr Hong Wan

Ahmad US, Parkinson EK, Wan H ( 2022 ) . Desmoglein-3 induces YAP phosphorylation and inactivation during collective migration of oral carcinoma cells . Molecular Oncology
Rehman A, Huang Y, Wan H ( 2021 ) . Evolving mechanisms in the pathophysiology of pemphigus vulgaris: A review emphasizing the role of desmoglein 3 in regulating p53 and the yes-associated protein . Life vol. 11 , ( 7 )
Huang Y, Jedličková H, Cai Y, Rehman A, Gammon L, Ahmad US, Uttagomol J, Parkinson EK et al. ( 2021 ) . Oxidative Stress-Mediated YAP Dysregulation Contributes to the Pathogenesis of Pemphigus Vulgaris . Frontiers in Immunology vol. 12 ,
Rehman A, Wan H ( 2020 ) . A novel regulatory pathway of Desmoglein-3 in keratinocyte stress response . Journal of Cellular Signaling vol. 1 , ( 4 ) 169 - 179 .
Houacine S, Kang A, Parkinson EK, Wan H, Fortune F ( 2020 ) . Induction of p53 in keratinocyte cultures treated with Behçet's patient sera . Journal of Oral Pathology and Medicine vol. 49 , ( 5 ) 435 - 442 .
Uttagomol J, Ahmad US, Rehman A, Huang Y, Laly AC, Kang A, Soetaert J, Chance R et al. ( 2019 ) . Evidence for the desmosomal cadherin desmoglein-3 in regulating YAP and Phospho-YAP in keratinocyte responses to mechanical forces . International Journal of Molecular Sciences vol. 20 , ( 24 )
Wan H, Li X, Ahmad U, Huang Y, Uttagomol J, Rehman A, Zhou K, Warnes G et al. ( 2019 ) . Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells . Mechanisms of Ageing and Development
Rehman A, Cai Y, Hünefeld C, Jedličková H, Huang Y, Teck Teh M, Sharif Ahmad U, Uttagomol J et al. ( 2019 ) . The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53 . Cell Death and Disease vol. 10 , ( 10 )
Hoque Apu E, Akram SU, Rissanen J, Wan H, Salo T ( 2018 ) . Desmoglein 3 – Influence on oral carcinoma cell migration and invasion . Experimental Cell Research vol. 370 , ( 2 ) 353 - 364 .
Wan H ( 2018 ) . Desmoglein-3 . Encyclopedia of Signaling Molecules ,
Uttagomol J, Connelly J, Wan H ( 2018 ) . Evidence for desmoglein 3 as a mechanosensor in keratinocytes . BRITISH JOURNAL OF DERMATOLOGY . vol. 178 , E406 - E407 .
Rehman A, Cai Y, Jedlickova H, Harwood C, Bergamaschi D, Wan H ( 2018 ) . Novel role of desmoglein-3 acting as a negative regulator of p53 . BRITISH JOURNAL OF DERMATOLOGY . vol. 178 , E417 - E418 .
Uttagomol J, Aguedo A, Connelly J, Wan H ( 2018 ) . Desmoglein 3 acts as a mechanosensor in keratinocytes . JOURNAL OF INVESTIGATIVE DERMATOLOGY . Conference: IID vol. 138 , S146 - S146 .
Rehman A, Cai Y, Jedlikova H, Harwood C, Bergamaschi D, Wan H ( 2018 ) . Desmoglein-3 acts as an anti-stress protein via suppression of p53 . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 138 , S229 - S229 .
Wan H, Gadmor H, Brown L ( 2018 ) . Anchoring junctions in the oral mucosa: Adherens junctions and desmosomes . Oral Mucosa in Health and Disease: A Concise Handbook ,
Wan H, Gadmor H, Brown L ( 2018 ) . Cell-Cell interactions in the oral mucosa: Tight junctions and gap junctions . Oral Mucosa in Health and Disease: A Concise Handbook ,
Wan H ( 2016 ) . Desmoglein-3 . Encyclopedia of Signaling Molecules ,
WAN H ( 2016 ) . Desmoglein 3 acts as a potential oncogene in promoting cancer cell migration and invasion through regulating AP-1 and PKC dependent-Ezrin activation . Conference: British Skin Foundation Skin Deep-20th Anniversary Symposium ( royal college of physicians, London ) from: 13/10/2016 to: 13/10/2016 , vol. 175 , 65 - 66 .
TEH M, Wan HONG ( 2016 ) . Independent Evaluation of a FOXM1-based Quantitative Malignancy Diagnostic System (qMIDS) on Head and Neck Squamous Cell Carcinomas . Oncotarget vol. 7 , ( 34 ) 54555 - 54563 .
Mofta H, Dias K, Hoque Apu E, Liu L, Uttagomal J, Bergmeier L, Kermorgan S, Wan H ( 2016 ) . Desmoglein 3 regulates membrane trafficking of cadherins, an implication in cell-cell adhesion . Cell Adhesion & Migration
Wan H, Lin K, Tsang SM, Uttagomol J ( 2016 ) . Evidence for Dsg3 in regulating Src signaling by competing with it for binding to caveolin-1 . Data in Brief vol. 6 , 124 - 134 .
WAN H ( 2015 ) . Desmoglein 3: a help or a hindrance in cancer progression? . Cancers vol. Cancers 2015 , ( 7 ) 266 - 286 .
Brown L, Wan H ( 2015 ) . Desmoglein 3: A help or a hindrance in cancer progression? . Cancers vol. 7 , ( 1 ) 266 - 286 .
Wan H, Kenny F, Connelly J ( 2014 ) . DESMOGLEIN 3 ACTS AS A MECHANOSENSOR IN RESPONSE TO ENVIRONMENTAL MECHANICAL PROPERTY . ANTICANCER RESEARCH vol. 34 , ( 10 ) 6238 - 6238 .
Moftah H, Diaz K, Kermorgant S, Wan H ( 2014 ) . Role for Desmoglein 3 in regulating E-cadherin trafficking . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S29 - S29 .
Brown L, Waseem A, Cruz IN, Szary J, Gunic E, Mannan T, Unadkat M, Yang M et al. ( 2013 ) . Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation . Oncogene vol. 33 , 2363 - 2374 .
Teh M-T, Hutchison IL, Costea DE, Neppelberg E, Liavaag PG, Purdie K, Harwood C, Wan H et al. ( 2013 ) . Exploiting FOXM1-orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis . Int J Cancer vol. 132 , ( 9 ) 2095 - 2106 .
Tsang SM, Brown L, Gadmor H, Gammon L, Fortune F, Wheeler A, Wan H ( 2012 ) . Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1/Cdc42 in the regulation of actin organisation and dynamics . Exp Cell Res vol. 318 , ( 18 ) 2269 - 2283 .
Brown LE, Gunic E, Unadkat M, Mannan T, Tsang S, Ahmed W, Valderrama F, O'Toole EA et al. ( 2012 ) . Desmoglein 3 regulates cancer cell migration through Protein Kinase C dependent-ezrin activation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S37 - S37 .
Wan H, Brown L, Gunic E, Mannan T, Tsang S, Valderrama F, O'Toole E ( 2012 ) . Desmoglein 3 Regulates Cancer Cell Migration Through PKC Dependent-ezrin Activation . EUROPEAN JOURNAL OF CANCER . vol. 48 , S45 - S46 .
Tsang SM, Brown L, Lin K, Liu L, Piper K, O'Toole EA, Grose R, Hart IR et al. ( 2012 ) . Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris . J Pathol vol. 227 , ( 1 ) 81 - 93 .
Bose A, Teh M-T, Hutchison IL, Wan H, Leigh IM, Waseem A ( 2012 ) . Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling . PLoS One vol. 7 , ( 6 )
Mannan T, Jing S, Foroushania SH, Fortune F, Wan H ( 2011 ) . RNAi-mediated inhibition of the desmosomal cadherin (desmoglein 3) impairs epithelial cell proliferation . CELL PROLIFERAT vol. 44 , ( 4 ) 301 - 310 .
Teh M-T, Parkinson EK, Thurlow JK, Liu F, Fortune F, Wan H ( 2011 ) . A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinoma . J Oral Pathol Med vol. 40 , ( 1 ) 67 - 76 .
Gemenetzidis E, Costea DE, Parkinson EK, Waseem A, Wan H, Teh MT ( 2011 ) . Induction of human epithelial stem/progenitor expansion by FOXM1 (Cancer Research (2010) 70, (9515-9526)) . Cancer Research vol. 71 , ( 1 )
Cabral RM, Wan H, Cole CL, Abrams DJ, Kelsell DP, South AP ( 2010 ) . Identification and characterisation of DSPla, a novel isoform of human desmoplakin . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 130 , S16 - S16 .
Cabral RM, Wan H, Cole CL, Abrams DJ, Kelsell DP, South AP ( 2010 ) . Identification and characterization of DSPIa, a novel isoform of human desmoplakin . CELL TISSUE RES vol. 341 , ( 1 ) 121 - 129 .
Tsang S, Liu L, Teh M, Wheeler A, Piper K, Grose R, Hart I, Garrod D et al. ( 2010 ) . Novel role for human desmoglein 3 in regulating E-cadherin mediated adherens junctions through Src family kinase activation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 130 , S33 - S33 .
Tsang SM, Liu L, Teh M-T, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F et al. ( 2010 ) . Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src . PloS ONE vol. 5 , ( 12 )
Gemenetzidis E, Elena-Costea D, Parkinson EK, Waseem A, Wan H, Teh MT ( 2010 ) . Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1 . Cancer Research vol. 70 , ( 22 ) Article N/A , 9515 - 9526 .
Gemenetzidis E, Bose A, Riaz AM, Chaplin T, Young BD, Ali M, Sugden D, Thurlow JK et al. ( 2009 ) . FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation . PLoS One vol. 4 , ( 3 )
Wan H, South AP, Hart IR ( 2007 ) . Increased keratinocyte proliferation initiated through downregulation of desmoplakin by RNA interference . Exp Cell Res vol. 313 , ( 11 ) 2336 - 2344 .
Wan H, Yuan M, Simpson C, Allen K, Gavins FNE, Ikram MS, Basu S, Baksh N et al. ( 2007 ) . Stem/progenitor cell-like properties of desmoglein 3dim cells in primary and immortalized keratinocyte lines . Stem Cells vol. 25 , ( 5 ) 1286 - 1297 .
Wan H, Yuan M, Simpson C, Allen K, Gavins FN, Ikram MS, Basu S, Baksh N et al. ( 2007 ) . Stem/progenitor cell-like properties of Desmoglein 3dim cells in primary and immortalized keratinocyte lines . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 127 , S66 - S66 .
Wan H, Hart IR ( 2005 ) . Downregulation of desmoplakin by RNA interference in HaCaT cells results in increased cellular proliferation . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 834 - 834 .
South AP, Wan H, Hart IR ( 2005 ) . Generation of stable knockdown in keratinocyte cell lines using retrovirus-mediated RNA interference . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 846 - 846 .
Wan H, Hart IR ( 2005 ) . Specific downregulation of Desmoglein 3 by RNA interference in HaCaT keratinocyte cells causes decreased cell proliferation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 124 , A29 - A29 .
Wan H, Dopping-Hepenstal PJC, Gratian MJ, Stone MG, Zhu G, Purkis PE, South AP, Keane F et al. ( 2004 ) . Striate palmoplantar keratoderma arising from desmoplakin and desmoglein 1 mutations is associated with contrasting perturbations of desmosomes and the keratin filament network . BRIT J DERMATOL vol. 150 , ( 5 ) 878 - 891 .
Wan H, Stone MG, Simpson C, Reynolds LE, Marshall JF, Hart IR, Hodivala-Dilke KM, Eady RAJ ( 2003 ) . Desmosomal proteins, including desmoglein 3, serve as novel negative markers for epidermal stem cell-containing population of keratinocytes . J CELL SCI vol. 116 , ( 20 ) 4239 - 4248 .
South AP, Wan H, Stone MG, Dopping-Hepenstal PJC, Purkis PE, Marshall JF, Leigh IM, Eady RAJ et al. ( 2003 ) . Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability . J CELL SCI vol. 116 , ( 16 ) 3303 - 3314 .
Wan H, Dopping-Hepenstal PJC, Gratian MJ, Stone MG, McGrath JA, Eady RAJ ( 2003 ) . Desmosomes exhibit site-specific features in human palm skin . EXP DERMATOL vol. 12 , ( 4 ) 378 - 388 .
Wan H, Marshall J, Reynolds LE, Stone MG, McGrath JA, Hodivala-Dilke KM, Eady RAJ ( 2002 ) . Diversity of desmoplakin expression in basal palm keratinocytes: A possible clue to the identification of epidermal stem cells . J INVEST DERMATOL vol. 119 , ( 3 ) 714 - 714 .
South A, Wan H, Stone M, Dopping-Hepenstal P, Purkis P, Leigh I, Eady R, Hart I et al. ( 2002 ) . Lack of plakophilin-1 reduces calcium stability of membrane bound desmosomal components . J INVEST DERMATOL vol. 119 , ( 1 ) 226 - 226 .
Whittock NV, Smith FJ, Wan H, Mallipeddi R, Griffiths WA, Dopping-Hepenstal P, Ashton GH, Eady RA et al. ( 2002 ) . Frameshift mutation in the V2 domain of human keratin 1 results in striate palmoplantar keratoderma . J INVEST DERMATOL vol. 118 , ( 5 ) 838 - 844 .
Hamada T, McLean WHI, Ramsay M, Ashton GHS, Nanda A, Jenkins T, Edelstein I, South AP et al. ( 2002 ) . Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1) . HUM MOL GENET vol. 11 , ( 7 ) 833 - 840 .
Whittock NV, Wan H, Morley SM, Garzon MC, Kristal L, Hyde P, McLean WHI, Pulkkinen L et al. ( 2002 ) . Compound heterozygosity for non-sense and mis-sense mutations in desmoplakin underlies skin fragility/woolly hair syndrome . J INVEST DERMATOL vol. 118 , ( 2 ) 232 - 238 .
Wan H, Dopping-Hepenstal T, Gratian M, Stone MG, McGrath JA, Eady RAJ ( 2001 ) . Desmosomes exhibit site-specific features in human palm skin . J INVEST DERMATOL vol. 117 , ( 3 ) 789 - 789 .
Whittock NV, Wan H, Smith FJD, Keane F, Mallipedi R, Griffiths WAD, Dopping-Hepenstal P, Ashton GHS et al. ( 2001 ) . Frameshift mutation in the V2 domain of keratin I causes the striate form of palmoplantar keratoderma . J INVEST DERMATOL vol. 117 , ( 3 ) 766 - 766 .
Springall T, Sheerin NS, Abe K, Holers VM, Wan H, Sacks SH ( 2001 ) . Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli . NAT MED vol. 7 , ( 7 ) 801 - 806 .
Wan H, Winton HL, Soeller C, Taylor GW, Gruenert DC, Thompson PJ, Cannell MB, Stewart GA et al. ( 2001 ) . The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus . CLIN EXP ALLERGY vol. 31 , ( 2 ) 279 - 294 .
Ring PC, Wan H, Schou C, Kroll KA, Roepstorff P, Robinson C ( 2000 ) . The 18-kDa form of cat allergen Felis domesticus 1 (Fel d 1) is associated with gelatin- and fibronectin-degrading activity . Clin.Exp.Allergy vol. 30 , ( 8 ) 1085 - 1096 .
Wan H, Winton HL, Soeller C, Stewart GA, Thompson PJ, Gruenert DC, Cannell MB, Garrod DR et al. ( 2000 ) . Tight junction properties of the immortalized human bronchial epithelial cell lines Calu-3 and 16HBE14o- . Eur.Respir.J. vol. 15 , ( 6 ) 1058 - 1068 .
Wan H, Winton HL, Soeller C, Gruenert DC, Thompson PJ, Cannell MB, Stewart GA, Garrod DR et al. ( 2000 ) . Quantitative structural and biochemical analyses of tight junction dynamics following exposure of epithelial cells to house dust mite allergen Der p 1 . Clin.Exp.Allergy vol. 30 , ( 5 ) 685 - 698 .
Wan H, Winton HL, Soeller C, Tovey ER, Gruenert DC, Thompson PJ, Stewart GA, Taylor GW et al. ( 1999 ) . Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions . J.Clin.Invest vol. 104 , ( 1 ) 123 - 133 .
Robinson C, Wan H, Winton HL, Soeller C, Cannell MB, Gruenert DC, Thompson PJ, Stewart GA et al. ( 1999 ) . Cleavage of occludin by Der P 1 facilitates transepithelial permeation of allergen . AM J RESP CRIT CARE vol. 159 , ( 3 ) A856 - A856 .
Robinson C, Wan H, Winton HL ( 1999 ) . Proteinases and sensitization: house mites and enzyme detergents - Response . CLIN EXP ALLERGY vol. 29 , ( 2 ) 281 - 282 .
Robinson C, Wan H, Winton HL ( 1999 ) . Response by Robinson, Wan and Winton . Clin.Exp.Allergy vol. 29 , ( 2 ) 281 - 282 .
Robinson C, Wan H, Winton HL, Garrod DR, Stewart GA, Thompson PJ ( 1999 ) . Proteinase Allergens of House Dust Mites: Molecular Biology, Biochemistry and Possible Functional Significance of Their Enzyme Activity . Molecular Biology of the Lung ,
Winton HL, Wan H, Cannell MB, Gruenert DC, Thompson PJ, Garrod DR, Stewart GA, Robinson C ( 1998 ) . Cell lines of pulmonary and non-pulmonary origin as tools to study the effects of house dust mite proteinases on the regulation of epithelial permeability . Clin.Exp.Allergy vol. 28 , ( 10 ) 1273 - 1285 .
Winton HL, Wan H, Cannell MB, Thompson PJ, Garrod DR, Stewart GA, Robinson C ( 1998 ) . Class specific inhibition of house dust mite proteinases which cleave cell adhesion, induce cell death and which increase the permeability of lung epithelium . Br.J.Pharmacol. vol. 124 , ( 6 ) 1048 - 1059 .
Robinson C, Wan H, Winton HL ( 1998 ) . Epithelial repair in asthma. Do the benefits of house dust mite avoidance result from proteinase avoidance? . Clin.Exp.Allergy vol. 28 , ( 5 ) 530 - 533 .
Wan H, Williams RL, Doherty PJ, Williams DF ( 1997 ) . A study of cell behaviour on the surfaces of multifilament materials . J.Mater.Sci.Mater.Med. vol. 8 , ( 1 ) 45 - 51 .
WAN H, WILLIAMS R, DOHERTY P, WILLIAMS DF ( 1994 ) . A STUDY OF THE REPRODUCIBILITY OF THE MTT TEST . J MATER SCI-MATER M vol. 5 , ( 3 ) 154 - 159 .
Wan H, Williams RL, Doherty PJ, Williams DF ( 1994 ) . The cytotoxicity evaluation of Kevlar and silicon carbide by MTT assay . Journal of Material Science: Materials in Medicine vol. 5 , ( 6-7 ) 441 - 445 .