Skip to main content
Research

Publications: Prof Denise Sheer

Adiutori R, Puentes F, Bremang M, Lombardi V, Zubiri I, Leoni E, Aarum J, Sheer D et al. ( 2021 ) . Analysis of circulating protein aggregates as a route of investigation into neurodegenerative disorders . Brain Commun vol. 3 , ( 3 )
Patel A, Jones T, Woodward L, Dokal A, Rajeeve V, Cutillas P, Stone T, Jacques T et al. ( 2020 ) . LGG-57. SIGNALLING MECHANISMS IN PAEDIATRIC LOW-GRADE GLIOMA . Neuro-Oncology vol. 22 , ( Suppl 3 ) iii377 - iii377 .
Patel A, Jones T, Woodward L, Dokal A, Rajeeve V, Cutillas P, Stone T, Jacques T et al. ( 2020 ) . SIGNALLING MECHANISMS IN PAEDIATRIC LOW-GRADE GLIOMA . NEURO-ONCOLOGY . vol. 22 , 377 - 377 .
Aarum J, Cabrera CP, Jones TA, Rajendran S, Adiutori R, Giovannoni G, Barnes MR, Malaspina A et al. ( 2020 ) . Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates . EMBO Reports vol. 21 , ( 10 )
Aarum J, Cabrera CP, Jones TA, Rajendran S, Adiutori R, Giovannoni G, Barnes MR, Malaspina A et al. ( 2020 ) . Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates . EMBO Reports vol. 21 , ( 10 ) Article ARTN e49585 ,
Dumas A, Pomella N, Rosser G, Guglielmi L, Vinel C, Millner T, Rees J, Aley N et al. ( 2020 ) . Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment . The EMBO Journal
Merve A, Zhang X, Pomella N, Acquati S, Hoeck JD, Dumas A, Rosser G, Li Y et al. ( 2019 ) . Correction to: C-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism (Acta Neuropathologica Communications (2019) 7:95 DOI: 10.1186/s40478-019-0739-x) . Acta Neuropathologica Communications vol. 7 , ( 1 )
Merve A, Zhang X, Pomella N, Acquati S, Hoeck J, Dumas A, Rosser G, Li Y et al. ( 2019 ) . Choroid plexus papillomas are induced by c-Myc overexpression in the choroid plexus via a T-cell inflammatory mechanism . Neuro-Oncology . vol. 21 , iv9 - iv10 .
Caley M, Marsh S, Martins VL, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al. ( 2019 ) . 298 Defective DNA Repair and Chromosomal Instability in RDEB . Journal of Investigative Dermatology . vol. 139 ,
Marsh S, Caley MP, Martins VLC, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al. ( 2019 ) . Type VII collagen and Nesprin 2: LINCing the basement membrane to altered cell cycle and increased DNA damage . BRITISH JOURNAL OF DERMATOLOGY . vol. 180 , E188 - E189 .
Merve A, Zhang X, Pomella N, Acquati S, Hoeck JD, Dumas A, Rosser G, Li Y et al. ( 2019 ) . C-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism . Acta Neuropathologica Communications vol. 7 , ( 1 )
Adiutori R, Aarum J, Zubiri I, Bremang M, Jung S, Sheer D, Pike I, Malaspina A ( 2018 ) . The proteome of neurofilament-containing protein aggregates in blood . Biochemistry and Biophysics Reports vol. 14 , 168 - 177 .
Jeyapalan JN, Doctor GT, Jones TA, Alberman SN, Tep A, Haria CM, Schwalbe EC, Morley ICF et al. ( 2016 ) . DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas . Acta Neuropathologica Communications vol. 4 , ( 1 )
Noor DAM, Jeyapalan JN, Alhazmi S, Carr M, Squibb B, Wallace C, Tan C, Cusack M et al. ( 2016 ) . Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines . NPJ Genom Med vol. 1 ,
Jones TA, Jeyapalan JN, Forshew T, Tatevossian RG, Lawson ARJ, Patel SN, Doctor GT, Mumin MA et al. ( 2015 ) . Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-κB pathways . Acta neuropathologica communications vol. 3 ,
Jeyapalan JN, Haria CM, Jones TA, Tatevossian RG, Qaddoumi I, Ellison DW, Sheer D ( 2015 ) . PO77EXPRESSION OF THE ONCOGENIC SPLICE VARIANT OF CYCLIN D1, CCND1B, IN PAEDIATRIC LOW GRADE GLIOMAS . Neuro-Oncology vol. 17 , ( suppl_8 ) viii14 - viii14 .
Sheer D, Jeyapalan J, Doctor GT, Jones TA, Alberman SN, Tep A, Haria CM, Schwalbe EC et al. ( 2015 ) . DNA METHYLATION ANALYSIS OF PAEDIATRIC LOW-GRADE ASTROCYTOMAS IDENTIFIES A TUMOUR-SPECIFIC SIGNATURE AT A SET OF ENHANCERS . PEDIATRIC BLOOD & CANCER vol. 62 , S283 - S284 .
Jeyapalan JN, Haria CM, Jones TA, Tatevossian RG, Qaddoumi I, Ellison DW, Sheer D ( 2015 ) . EXPRESSION OF THE ONCOGENIC SPLICE VARIANT OF CYCLIN D1, CCND1B, IN PAEDIATRIC LOW GRADE GLIOMAS . NEURO-ONCOLOGY . vol. 17 , 14 - 14 .
Coll-Bastus N, Mao X, Young BD, Sheer D, Lu Y-J ( 2015 ) . DNA replication-dependent induction of gene proximity by androgen . Hum Mol Genet vol. 24 , ( 4 ) 963 - 971 .
Jeyapalan JN, Jones TA, Tatevossian RG, Qaddoumi I, Ellison D, Sheer D ( 2014 ) . MICRORNA PROFILING USING SMALL RNA-SEQ IN PAEDIATRIC LOW GRADE GLIOMAS . NEURO-ONCOLOGY . vol. 16 ,
Jeyapalan JN, Jones TA, Tatevossian RG, Qaddoumi I, Ellison DW, Sheer D ( 2014 ) . OP17MICRORNA PROFILING USING SMALL RNA-SEQ IN PAEDIATRIC LOW GRADE GLIOMAS . Neuro-Oncology vol. 16 , ( suppl_6 ) vi19 - vi19 .
Ottaviani D, LeCain M, Sheer D ( 2014 ) . The role of microhomology in genomic structural variation . Trends Genet vol. 30 , ( 3 ) 85 - 94 .
Bastus NC, Mao X, Young BD, Sheer D, Lu Y-J ( 2014 ) . Novel function of androgen receptor-the regulation of DNA replication and genomic movement . INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE vol. 34 , S89 - S89 .
Ogunkolade BW, Jones TA, Aarum J, Szary J, Owen N, Ottaviani D, Mumin MA, Patel S et al. ( 2013 ) . BORIS/CTCFL is an RNA-binding protein that associates with polysomes . BMC Cell Biol vol. 14 ,
Henriquez NV, Forshew T, Tatevossian R, Ellis M, Richard-Loendt A, Rogers H, Jacques TS, Reitboeck PG et al. ( 2013 ) . Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumor propagation in vitro . Cancer Res vol. 73 , ( 18 ) 5834 - 5844 .
Zhang J, Wu G, Miller CP, Tatevossian RG, Dalton JD, Tang B, Orisme W, Punchihewa C et al. ( 2013 ) . Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas . Nature Genetics vol. 45 , ( 6 ) 602 - 612 .
Forshew T, Lewis P, Waldman A, Peterson D, Glaser M, Brock C, Sheer D, Mulholland PJ ( 2013 ) . Three different brain tumours evolving from a common origin . Oncogenesis vol. 2 ,
Jeyapalan JN, Patel SN, Forshew T, Lawson ARJ, Tatevossian RG, Corbett-Jones T, Mumin MA, Picker SR et al. ( 2012 ) . MICRORNA SIGNATURES IN A BROAD COHORT OF PAEDIATRIC BRAIN TUMOURS . PEDIATRIC BLOOD & CANCER vol. 59 , ( 6 ) 1084 - 1084 .
Jeyapalan JN, Morley ICF, Hill AA, Mumin MA, Tatevossian RG, Qaddoumi I, Ellison DW, Sheer D ( 2012 ) . DNA METHYLATION PROFILING OF LOW GRADE ASTROCYTOMAS USING THE ILLUMINA 450K BEADCHIP REVEALS CHANGES IN GENES INVOLVED IN BRAIN DEVELOPMENT AND DRUG RESISTANCE . NEURO-ONCOLOGY . vol. 14 , 3 - 3 .
Ottaviani D, Lever E, Mao S, Christova R, Ogunkolade BW, Jones TA, Szary J, Aarum J et al. ( 2012 ) . CTCF binds to sites in the major histocompatibility complex that are rapidly reconfigured in response to interferon-gamma . Nucleic Acids Res vol. 40 , ( 12 ) 5262 - 5270 .
Jeyapalan JN, Morley ICF, Hill AA, Tatevossian RG, Qaddoumi I, Ellison D, Sheer D ( 2012 ) . DNA METHYLATION PROFILING OF LOW GRADE ASTROCYTOMAS USING THE ILLUMINA 450K BEADCHIP REVEALS CHANGES IN GENES INVOLVED IN BRAIN DEVELOPMENT AND DRUG RESISTANCE . NEURO-ONCOLOGY . vol. 14 , 77 - 77 .
Viana-Pereira M, Pereira M, Burford A, Jury A, Popov S, Perryman L, Bax D, Forshew T et al. ( 2012 ) . MOLECULAR DETERMINANTS OF EFFICACY OF MET RECEPTOR INHIBITION IN PAEDIATRIC GLIOBLASTOMA . NEURO-ONCOLOGY . vol. 14 , 66 - 67 .
Tatevossian R, Qaddoumi I, Tang B, Dalton J, Shurtleff S, Punchihewa C, Orisme W, Neale G et al. ( 2012 ) . RAF GENE ABNORMALITIES DEFINE SUBSETS OF PEDIATRIC LOW-GRADE GLIOMAS AND GLIONEURONAL TUMORS . NEURO-ONCOLOGY . vol. 14 , 77 - 78 .
Ellison D, Tatevossian R, Qaddoumi I, Tang B, Dalton J, Shurtleff S, Punchihewa C, Orisme W et al. ( 2012 ) . RAF Gene Abnormalities Define Subsets of Pediatric Low-Grade Gliomas and Glioneuronal Tumors . JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY . vol. 71 , 577 - 577 .
Nicolaides T, Hariono S, Barkovich K, Hashizume R, Rowitch D, Weiss W, Sheer D, Baker S et al. ( 2011 ) . TARGETED THERAPY FOR BRAFV600E MUTANT MALIGNANT ASTROCYTOMA . NEURO-ONCOLOGY vol. 13 , 112 - 112 .
Bezecny P, Sang NJPXWF, Mumin MA, Pieri C, Mulholland PJ, Sheer D ( 2011 ) . Addition of Erlotinib Changes Gene Expression in Glioblastoma Cell Lines Treated With Vorinostat . EUROPEAN JOURNAL OF CANCER . vol. 47 , S578 - S578 .
Hashizume R, Aoki Y, Hariono S, Huillard E, Rowitch D, Jones C, Forshew T, Sheer D et al. ( 2011 ) . COMBINATION-TARGETED THERAPY SHOWS IMPROVED EFFICACY AGAINST BRAF(V600E) MUTANT MALIGNANT ASTROCYTOMAS . NEURO-ONCOLOGY . vol. 13 , I1 - I1 .
Tatevossian R, Tang B, Dalton J, Forshew T, Lawson A, Ma J, Neale G, Shurtleff S et al. ( 2011 ) . MYB UPREGULATION AND GENETIC ABERRATIONS IN A SUBSET OF PEDIATRIC LOW-GRADE GLIOMAS . NEURO-ONCOLOGY . vol. 13 , I5 - I5 .
Lawson ARJ, Hindley GFL, Forshew T, Tatevossian RG, Jamie GA, Kelly GP, Neale GA, Ma J et al. ( 2011 ) . RAF GENE FUSION BREAKPOINTS IN PEDIATRIC BRAIN TUMORS ARE CHARACTERIZED BY SIGNIFICANT ENRICHMENT OF SEQUENCE MICROHOMOLOGY . NEURO-ONCOLOGY . vol. 13 , I24 - I25 .
Lawson ARJ, Hindley GFL, Forshew T, Tatevossian RG, Jamie GA, Kelly GP, Neale GA, Ma J et al. ( 2011 ) . RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology . Genome Res vol. 21 , ( 4 ) 505 - 514 .
Jeyapalan JN, Mumin MA, Forshew T, Lawson ARJ, Tatevossian RG, Jacques TS, Sheer D ( 2011 ) . MICRORNA EXPRESSION IN PAEDIATRIC BRAIN TUMOURS . NEURO-ONCOLOGY . vol. 13 , 6 - 6 .
Jones TA, Ogunkolade BW, Szary J, Aarum J, Mumin MA, Patel S, Pieri CA, Sheer D ( 2011 ) . Widespread expression of BORIS/CTCFL in normal and cancer cells . PLoS One vol. 6 , ( 7 )
Tatevossian RG, Tang B, Dalton J, Forshew T, Lawson AR, Ma J, Neale G, Shurtleff SA et al. ( 2010 ) . MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas . ACTA NEUROPATHOL vol. 120 , ( 6 ) 731 - 743 .
Tatevossian R, Tang B, Forshew T, Lawson A, Dalton J, Ma J, Neale G, Broniscer A et al. ( 2010 ) . DNA COPY NUMBER CHANGES AND KIAA1549-BRAF FUSION GENE DETECTION IN 125 PEDIATRIC LOW-GRADE GLIOMAS . PEDIATR BLOOD CANCER vol. 55 , ( 5 ) 798 - 799 .
Bezecny P, Pieri C, Szary J, Mulholland PJ, Sheer D ( 2010 ) . HISTONE DEACETYLASE INHIBITOR VORINOSTAT REDUCES EXPRESSION OF PLATELET-DERIVED GROWTH FACTOR RECEPTOR A (PDGFRA) AND MATRIX METALLOPROTEINASE-2 (MMP2) GENES IN GLIOBLASTOMA CELL LINES . ANNALS OF ONCOLOGY . vol. 21 , 333 - 334 .
Lawson ARJ, Tatevossian RG, Phipps KP, Picker SR, Michalski A, Sheer D, Jacques TS, Forshew T ( 2010 ) . RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort . Acta Neuropathol vol. 120 , ( 2 ) 271 - 273 .
Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S et al. ( 2010 ) . Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome (Corrigendum) . NATURE vol. 466 , ( 7304 )
Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S et al. ( 2010 ) . Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome . Nature vol. 465 , ( 7299 ) 813 - 817 .
Forshew T, Lawson ARJ, Hindley GFL, Tatevossian RG, Jamie G, Ellison DW, Sheer D ( 2010 ) . BREAKPOINT ANALYSIS OF RAF GENE FUSIONS IN PAEDIATRIC LOW-GRADE ASTROCYTOMAS . NEURO-ONCOLOGY . vol. 12 , II23 - II23 .
Tatevossian RG, Lawson ARJ, Forshew T, Hindley GFL, Ellison DW, Sheer D ( 2010 ) . MAPK pathway activation and the origins of pediatric low-grade astrocytomas . J Cell Physiol vol. 222 , ( 3 ) 509 - 514 .
Lever E, Sheer D ( 2010 ) . The role of nuclear organization in cancer . J Pathol vol. 220 , ( 2 ) 114 - 125 .
Ellison D, Forshew T, Tatevossian R, Lawson A, Ma J, Neale G, Dalton J, Broniscer A et al. ( 2009 ) . ABNORMALITIES OF THE MAPK PATHWAY IN PEDIATRIC LOW-GRADE GLIOMAS . NEURO-ONCOLOGY . vol. 11 , 610 - 610 .
Forshew T, Tatevossian RG, Lawson ARJ, Ma J, Neale G, Ogunkolade BW, Jones TA, Aarum J et al. ( 2009 ) . Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas . J Pathol vol. 218 , ( 2 ) 172 - 181 .
Ellison D, Forshew T, Tatevossian R, Ma J, Neale G, Ogunkolade W, Dalton J, Bailey S et al. ( 2009 ) . Activation of the MAPK Pathway: A Signature Genetic Defect in Posterior Fossa Pilocytic Astrocytomas . JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY vol. 68 , ( 5 ) 566 - 567 .
Dorine B, Little L, Gaspar N, Perryman L, Marshall L, Viana-Pereira M, Jones T, Williams RD et al. ( 2009 ) . Molecular and Phenotypic Characterisation of Paediatric Glioma Cell Lines as Models for Preclinical Drug Development . PLoS.ONE vol. 4 , ( 4 )
Bax DA, Little SE, Gaspar N, Perryman L, Marshall L, Viana-Pereira M, Jones TA, Williams RD et al. ( 2009 ) . Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development . PLoS One vol. 4 , ( 4 )
Ottaviani D, Lever E, Mitter R, Jones T, Forshew T, Christova R, Tomazou EM, Rakyan VK et al. ( 2008 ) . Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex . Genome Res vol. 18 , ( 11 ) 1778 - 1786 .
Tatevossian R, Forshew T, Bax D, Mitter R, Jones C, Sheer D ( 2008 ) . IDENTIFICATION OF CANDIDATE TUMOR SUPPRESSOR GENES IN PEDIATRIC ASTROCYTOMA USING NONSENSE-MEDIATED DECAY INHIBITION AND DEVELOPMENT OF A NOVEL GENE INTERACTION NETWORK . NEURO-ONCOLOGY . vol. 10 , 803 - 803 .
Forshew T, Tatevossian R, Clifford S, Ellison D, Sheer D ( 2008 ) . MOLECULAR GENETIC AND EPIGENETIC ANALYSIS OF PEDIATRIC LOW-GRADE ASTROCYTIC GLIOMAS . NEURO-ONCOLOGY . vol. 10 , 800 - 800 .
Tomazou EM, Rakyan VK, Lefebvre G, Andrews R, Ellis P, Jackson DK, Langford C, Francis MD et al. ( 2008 ) . Generation of a genomic tiling array of the human Major Histocompatibility Complex (MHC) and its application for DNA methylation analysis . BMC Med Genomics vol. 1 , ( 1 )
Ottaviani D, Lever E, Takousis P, Sheer D ( 2008 ) . Anchoring the genome . Genome Biol vol. 9 , ( 1 )
Takousis P, Johonnett P, Williamson J, Sasieni P, Warnes G, Forshew T, Azuara V, Fisher A et al. ( 2007 ) . Replication timing profile reflects the distinct functional and genomic features of the MHC class II region . CELL CYCLE vol. 6 , ( 19 ) 2393 - 2398 .
Christova R, Jones T, Wu P-J, Bolzer A, Costa-Pereira AP, Watling D, Kerr IM, Sheer D ( 2007 ) . P-STAT1 mediates higher-order chromatin remodelling of the human MHC in response to IFNgamma . J Cell Sci vol. 120 , ( Pt 18 ) 3262 - 3270 .
Donev R, Newall A, Thome J, Sheer D ( 2007 ) . A role for SC35 and hnRNPA1 in the determination of amyloid precursor protein isoforms . MOL PSYCHIATR vol. 12 , ( 7 ) 681 - 690 .
Mulholland PJ, Fiegler H, Mazzanti C, Gorman P, Sasieni P, Adams J, Jones TA, Babbage JW et al. ( 2006 ) . Genomic profiling identifies discrete deletions associated with translocations in glioblastoma multiforme . CELL CYCLE vol. 5 , ( 7 ) 783 - 791 .
Enukashvily N, Donev R, Sheer D, Podgornaya O ( 2005 ) . Satellite DNA binding and cellular localisation of RNA helicase P68 . J CELL SCI vol. 118 , ( 3 ) 611 - 622 .
Wang J, Shiels C, Sasieni P, Wu PJ, Islam SA, Freemont PS, Sheer D ( 2004 ) . Promyelocytic leukemia nuclear bodies associate with transcriptionally active genomic regions . J Cell Biol vol. 164 , ( 4 ) 515 - 526 .
SASIENI PD, Wu PJ, Wang J, Shields C, Islam SA, Freemont PS, Sheer D ( 2004 ) . Promyelocytic leukaemia nuclear bodies associate with transcriptionally active genomic regions . Journal of Cell Biology. vol. 164 , ( 4 ) 515 - 526 .
Donev R, Horton R, Beck S, Doneva T, Vatcheva R, Bowen WR, Sheer D ( 2003 ) . Recruitment of heterogeneous nuclear ribonucleoprotein A1 in vivo to the LMP/TAP region of the major histocompatibility complex . J Biol Chem vol. 278 , ( 7 ) 5214 - 5226 .
Donev RM, Doneva TA, Bowen WR, Sheer D ( 2002 ) . HnRNP-A1 binds directly to double-stranded DNA in vitro within a 36 bp sequence . MOL CELL BIOCHEM vol. 233 , ( 1-2 ) 181 - 185 .
Williams RRE, Broad S, Sheer D, Ragoussis J ( 2002 ) . Subchromosomal positioning of the epidermal differentiation complex (EDC) in keratinocyte and lymphoblast interphase nuclei . EXP CELL RES vol. 272 , ( 2 ) 163 - 175 .
Shiels C, Islam SA, Vatcheva R, Sasieni P, Sternberg MJ, Freemont PS, Sheer D ( 2001 ) . PML bodies associate specifically with the MHC gene cluster in interphase nuclei . J Cell Sci vol. 114 , ( Pt 20 ) 3705 - 3716 .
Sheer D, Volpi E, Beck S, Horton R, Donev R ( 2001 ) . Large-Scale chromatin structure and function in the Major Histocompatibility Complex . J MED GENET vol. 38 , S16 - S16 .
Sheer D, Volpi EV ( 2001 ) . Human Chromosomes (4th Edition) . Chromosome Research vol. 9 , ( 6 ) 474 - 474 .
Wu PJ, Bardos JI, Sheer D, Freemont P, Saha V ( 2001 ) . Expression and association of the human trithorax and polycomb group of proteins . BRIT J CANCER vol. 85 , 109 - 109 .
Volpi EV, Sheer D, Uhlmann F ( 2001 ) . Cohesion, but not too close . Curr Biol vol. 11 , ( 10 )
Abdel-Rahman WM, Katsura K, Rens W, Gorman PA, Sheer D, Bicknell D, Bodmer WF, Arends MJ et al. ( 2001 ) . Spectral Karyotyping reveals a new subset of colorectal cancers characterized by balanced translocations . J PATHOL vol. 193 , 24A - 24A .
Abdel-Rahman WM, Katsura K, Rens W, Gorman PA, Sheer D, Bicknell D, Bodmer WF, Arends MJ et al. ( 2001 ) . Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement . P NATL ACAD SCI USA vol. 98 , ( 5 ) 2538 - 2543 .
Schultz J, Jones T, Bork P, Sheer D, Blencke S, Steyrer S, Wellbrock U, Bevec D et al. ( 2001 ) . Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 4q35 . GENOMICS vol. 71 , ( 3 ) 368 - 370 .
Sirivatanauksorn V, Sirivatanauksorn Y, Gorman PA, Davidson JM, Sheer D, Moore PS, Scarpa A, Edwards PAW et al. ( 2001 ) . Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping . INT J CANCER vol. 91 , ( 3 ) 350 - 358 .
Groet J, Ives JH, Jones TA, Chen L, Danton M, Flomen RH, Sheer D, Hrascan R et al. ( 2001 ) . Allelic loss in the gene-poor band 21q11 -> q21 in squamous non-small cell lung carcinoma: cloning of a novel ubiquitin specific protease from the minimal deleted region . CYTOGENET CELL GENET vol. 92 , ( 1-2 ) 16 - 16 .
SASIENI PD, Vatcheva R, Sheer D, Sternberg MJE, Freemont PS, Islam SA, Shiels C ( 2001 ) . PML bodies associate specifically with the MHC gene cluster in interphase nuclei . Journal of Cell Science vol. 114 , 3705 - 3716 .
Woodford-Richens K, Williamson J, Bevan S, Young J, Leggett B, Frayling I, Thway Y, Hodgson S et al. ( 2000 ) . Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium . Cancer Research vol. 60 , ( 9 ) 2477 - 2482 .
Groet J, Ives JH, Jones TA, Danton M, Flomen RH, Sheer D, Hraš¿an R, Paveli¿ K et al. ( 2000 ) . Narrowing of the region of allelic loss in 21q11-21 in squamous non- small cell lung carcinoma and cloning of a novel ubiquitin-specific protease gene from the deleted segment . Genes Chromosomes and Cancer vol. 27 , ( 2 ) 153 - 161 .
Roylance R, Gorman P, Harris W, Liebmann R, Barnes D, Hanby A, Sheer D ( 1999 ) . Comparative genomic hybridization of breast tumors stratified by histological grade reveals new insights into the biological progression of breast cancer . Cancer Research vol. 59 , ( 7 ) 1433 - 1436 .
Flomen RH, Gorman PA, Vatcheva R, Groet J, Bariši¿ I, Liguti¿ I, Sheer D, Nižeti¿ D ( 1997 ) . Rieger syndrome locus: A new reciprocal translocation t(4;12)(q25;q15) and a deletion del(4)(q25q27) both break between markers D4S2945 and D4S193 . Journal of Medical Genetics vol. 34 , ( 3 ) 191 - 195 .
Wang XC, Katso R, Butler R, Hanby AM, Poulsom R, Jones T, Sheer D, Ganesan TS ( 1996 ) . H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer . Mol Med vol. 2 , ( 2 ) 189 - 203 .
Dunne J, Hanby AM, Poulsom R, Jones TA, Sheer D, Chin WG, Da SM, Zhao Q et al. ( 1995 ) . Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule . Genomics vol. 30 , ( 2 ) 207 - 223 .
Shipley J, Williams S, O'Byrne A, Kearney L, Jones T, Young B, Dyer M, Catovsky D et al. ( 1995 ) . Characterization of a t(10;11)(p13-14;q14-21) in the monoblastic cell line U937 . Genes Chromosomes Cancer vol. 13 , ( 2 ) 138 - 142 .
Abrahamsen TG, Wesenberg F, Mørk S, Allen J, Hayes R, DaRosso R, Nirenberg A, Ali-Osman F et al. ( 1993 ) . Abstracts for the Tenth International Conference on Brain Tumour Research and Therapy . Journal of Neuro-Oncology vol. 15 , ( Suppl 1 ) s1 - s30 .
Wynford-Thomas D, Bond JA, Wyllie FS, Burns JS, Williams ED, Jones T, Sheer D, Lemoine NR ( 1990 ) . Conditional immortalization of human thyroid epithelial cells: A tool for analysis of oncogene action . Molecular and Cellular Biology vol. 10 , ( 10 ) 5365 - 5377 .
Lemoine NR, Mayall ES, Jones T, Sheer D, McDermid S, Kendall-Taylor P, Wynford-Thomas D ( 1989 ) . Characterisation of human thyroid epithelial cells immortalised in vitro by simian virus 40 DNA transfection . British Journal of Cancer vol. 60 , ( 6 ) 897 - 903 .
Sheer D ( 1985 ) . Genetic aspects of carcinogenesis . Br J Surg vol. 72 Suppl , S39 - S41 .