Publications: Prof Andrew Silver

Lewis A, Humphreys DT, Pan-Castillo B, Berti G, Felice C, Gordon H, Gadhok R, Nijhuis A et al. ( 2023 ) . Epigenetic and Metabolic Reprogramming of Fibroblasts in Crohn’s Disease Strictures Reveals Histone Deacetylases as Therapeutic Targets . Journal of Crohn's and Colitis

Murtough S, Babu D, Webb CM, Picard HLD, McGinty LA, Chao-Chu J, Pink R, Silver AR et al. ( 2023 ) . INVESTIGATING iRHOM2-ASSOCIATED TRANSCRIPTIONAL CHANGES IN TYLOSIS WITH ESOPHAGEAL CANCER . Gastro Hep Advances

Gordon H, Wichmann K, Lewis A, Sanders T, Wildemann M, Hoti I, Hornsby E, Kok KB et al. ( 2023 ) . Human Intestinal Dendritic Cells Can Overcome Retinoic Acid Signaling to Generate Proinflammatory CD4 T Cells with Both Gut and Skin Homing Properties . The Journal of Immunology vol. 212 , ( 1 ) 96 - 106 .

Feakins RM, Loughrey MB, Silver A ( 2023 ) . Buds, clusters, and transitions in 21st century colorectal carcinoma: revolution or reinvention?† . The Journal of Pathology vol. 261 , ( 2 ) 121 - 124 .

Lewis A, Sánchez S, Berti G, Pan-Castillo B, Nijhuis A, Mehta S, Eleid L, Gordon H et al. ( 2022 ) . Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease . Clinical Science vol. 136 , ( 19 ) 1405 - 1423 .

Shailes H, Tse WY, Freitas MO, Silver A, Martin SA ( 2022 ) . Statin Treatment as a Targeted Therapy for APC-Mutated Colorectal Cancer . Frontiers in Oncology vol. 12 ,

Lewis A, Pan-Castillo B, Berti G, Felice C, Gordon H, Gadhok R, Minicozzi A, Chinaleong J et al. ( 2021 ) . DOP23 Single-cell RNA sequencing identifies an important role for class I histone-deacetylase enzymes in intestinal myofibroblasts from patients with Crohn’s Disease strictures . Journal of Crohn's and Colitis vol. 15 , ( Supplement_1 ) s062 - s062 .

Felice C, Lewis A, Armuzzi A, Lindsay JO, Silver A ( 2021 ) . P079 Valproic acid increases MiR449a expression in intestinal mucosa from patients with inflammatory bowel disease . Journal of Crohn's and Colitis vol. 15 , ( Supplement_1 ) s181 - s181 .

Lewis A, Pan-Castillo B, Berti G, Felice C, Gordon H, Gadhok R, Minicozzi A, Chinaleong J et al. ( 2021 ) . Single-cell RNA sequencing identifies an important role for class I histone-deacetylase enzymes in intestinal myofibroblasts from patients with Crohn's Disease strictures . JOURNAL OF CROHNS & COLITIS . vol. 15 , S062 - S062 .

Felice C, Lewis A, Armuzzi A, Lindsay JO, Silver A ( 2021 ) . Valproic acid increases MiR449a expression in intestinal mucosa from patients with inflammatory bowel disease . JOURNAL OF CROHNS & COLITIS . vol. 15 , S181 - S181 .

Felice C, Lewis A, Iqbal S, Gordon H, Rigoni A, Colombo MP, Armuzzi A, Feakins R et al. ( 2020 ) . Intestinal Inflammation is Linked to Hypoacetylation of Histone 3 Lysine 27 and can be Reversed by Valproic Acid Treatment in Inflammatory Bowel Disease Patients . Cellular and Molecular Gastroenterology and Hepatology vol. 11 , ( 3 )

Hontecillas-Prieto L, Flores-Campos R, Silver A, de Álava E, Hajji N, García-Domínguez DJ ( 2020 ) . Synergistic Enhancement of Cancer Therapy Using HDAC Inhibitors: Opportunity for Clinical Trials . Frontiers in Genetics vol. 11 ,

Martin S ( 2019 ) . MLH1 deficiency leads to deregulated mitochondrial metabolism . Cell Death and Disease vol. 10 , 795 - 795 .

Lewis A, Nijhuis A, Berti G, Felice C, Jeffrey R, Iqbal S, Pomeranc AB, Aldelemi S et al. ( 2019 ) . DOP20 Drugs that modulate histone acetylation disrupt TGF-β-signalling and reduce collagen I expression in models of stricturing Crohn’s disease . Journal of Crohn's and Colitis vol. 13 , ( Supplement_1 ) s037 - s038 .

Lewis A, Jeffrey R, Kumagai T, Hawkey CJ, Clark MM, Allez M, Satsangi J, Rogler G et al. ( 2019 ) . OP20 Mucosal micoRNA profiles predict response to autologous stem-cell transplantation in Crohn’s disease . Journal of Crohn's and Colitis . vol. 13 , s014 - s014 .

Lewis A, Nijhuis A, Berti G, Bishop CL, Feakins R, Lindsay JO, Silver A ( 2019 ) . P035 Pharmacological inhibition of the canonical WNT signalling pathway represents a potential novel therapy for fibrosis in Crohn’s disease . Journal of Crohn's and Colitis . vol. 13 , s103 - s104 .

Lewis A, Nijhuis A, Berti G, Felice C, Jeffrey R, Iqbal S, Pomeranc AB, Aldelemi S et al. ( 2019 ) . Drugs that modulate histone acetylation disrupt TGF-β-signalling and reduce collagen I expression in models of stricturing Crohn's disease . JOURNAL OF CROHNS & COLITIS . vol. 13 , S38 - S38 .

Mehta SJ, Lewis A, Nijhuis A, Jeffery R, Biancheri P, Di Sabatino A, Feakins R, Silver A et al. ( 2018 ) . Epithelial down‐regulation of the miR‐200 family in fibrostenosing Crohn's disease is associated with features of epithelial to mesenchymal transition . Journal of Cellular and Molecular Medicine vol. 22 , ( 11 ) 5617 - 5628 .

Baker A-M, Cross W, Curtius K, Bakir IA, Choi C-HR, Davis HL, Temko D, Biswas S et al. ( 2018 ) . Evolutionary history of human colitis-associated colorectal cancer . Gut vol. 68 , ( 6 )

Baker A-M, Cross W, Curtius K, Choi C-HR, Al-Bakir I, Temko D, Martinez P, Williams M et al. ( 2018 ) . Abstract 5368: The evolutionary history of human colitis-associated colorectal cancer . Cancer Research . vol. 78 , 5368 - 5368 .

Mehta SJ, Lewis A, Nijhuis A, Jeffery R, Feakins R, Silver A, Lindsay JO ( 2018 ) . P002 Epithelial to mesenchymal transition is a hallmark of fibrostenosing Crohn’s disease and is associated with down regulation of the miR-200 family . Journal of Crohn's and Colitis vol. 12 , ( supplement_1 ) s91 - s92 .

Mehta SJ, Lewis A, Nijhuis A, Jeffery R, Feakins R, Silver A, Lindsay JO ( 2018 ) . Epithelial to mesenchymal transition is a hallmark of fibrostenosing Crohn's disease and is associated with down regulation of the miR-200 family . JOURNAL OF CROHNS & COLITIS . vol. 12 , S91 - S92 .

Bolland H, McIntyre A, Shams-Nateri A, Bishop C, Silver A ( 2018 ) . eIF4A2 is a regulator of hypoxic translation and colorectal tumour cell survival . BRITISH JOURNAL OF CANCER . vol. 119 , 23 - 23 .

Rigoni A, Poulsom R, Jeffery R, Mehta S, Lewis A, Yau C, Giannoulatou E, Feakins R et al. ( 2017 ) . Separation of Dual Oxidase 2 and Lactoperoxidase Expression in Intestinal Crypts and Species Differences May Limit Hydrogen Peroxide Scavenging During Mucosal Healing in Mice and Humans . Inflamm Bowel Dis vol. 24 , ( 1 ) 136 - 148 .

Shailes H, Bridge G, Foxler D, Sharp TV, Silver A, Martin SA ( 2017 ) . Abstract A31: Targeting APC loss using synthetic lethality in Colorectal Cancer . Molecular Cancer Therapeutics . vol. 16 , a31 - a31 .

Adam J, Ramracheya R, Chibalina MV, Ternette N, Hamilton A, Tarasov AI, Zhang Q, Rebelato E et al. ( 2017 ) . Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes . Cell Rep vol. 20 , ( 13 ) 3135 - 3148 .

Bustos V, Nolan ÁM, Nijhuis A, Harvey H, Parker A, Poulsom R, McBryan J, Thomas W et al. ( 2017 ) . GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions . Oncotarget vol. 5 , ( 0 ) 84258 - 84275 .

Reissig K, Silver A, Hartig R, Schinlauer A, Walluscheck D, Guenther T, Siedentopf S, Ross J et al. ( 2017 ) . Chk1 Promotes DNA Damage Response Bypass following Oxidative Stress in a Model of Hydrogen Peroxide-Associated Ulcerative Colitis through JNK Inactivation and Chromatin Binding . Oxid Med Cell Longev vol. 2017 , 9303158 - 9303158 .

Lessel W, Silver A, Jechorek D, Guenther T, Roehl F-W, Kalinski T, Roessner A, Poehlmann-Nitsche A ( 2017 ) . Inactivation of JNK2 as carcinogenic factor in colitis-associated and sporadic colorectal carcinogenesis . Carcinogenesis vol. 38 , ( 5 ) 559 - 569 .

Baker A-M, Davis CHRCH, Al-Bakir I, Martinez P, Temko D, Cross W, Williams M, Biswas S et al. ( 2017 ) . MULTI-REGION EXOME SEQUENCING REVEALS THE CLONAL EVOLUTION OF COLITIS-ASSOCIATED COLORECTAL CANCER . GASTROENTEROLOGY . Conference: Pathological Society vol. 152 , S983 - S984 .

Lewis A, Felice C, Kumagai T, Lai C, Singh K, Jeffery RR, Feakins R, Giannoulatou E et al. ( 2017 ) . The miR-200 family is increased in dysplastic lesions in ulcerative colitis patients . PLoS One vol. 12 , ( 3 ) e0173664 - e0173664 .

Nijhuis A, Thompson H, Adam J, Parker A, Gammon L, Lewis A, Bundy JG, Tomoyoshi S et al. ( 2017 ) . Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance . Human Molecular Genetics

Nijhuis A, Curciarello R, Mehta S, Feakins R, Bishop CL, Lindsay JO, Silver A ( 2017 ) . MCL-1 is modulated in Crohn's disease fibrosis by miR-29b via IL-6 and IL-8 . Cell Tissue Res

Lewis A, Felice C, Nihjuis A, Iqbal S, Mehta S, Feakins R, Armuzzi A, Silver A et al. ( 2017 ) . Hypoacetylation of histone-3 is a hallmark of intestinal fibrosis in Crohn's disease . JOURNAL OF CROHNS & COLITIS . vol. 11 , S17 - S17 .

Shailes H, Bridge G, Foxler D, Sharp TV, Silver A, Martin SA ( 2017 ) . Targeting APC loss using synthetic lethality in Colorectal Cancer . MOLECULAR CANCER THERAPEUTICS . vol. 16 ,

Walton S-J, Lewis A, Jeffery R, Thompson H, Feakins R, Giannoulatou E, Yau C, Lindsay JO et al. ( 2016 ) . Familial adenomatous patients with desmoid tumours show increased expression of miR-34a in serum and high levels in tumours . Oncoscience vol. 3 , ( 5-6 ) 173 - 185 .

Alzoubi S, Brody L, Rahman S, Mahul-Mellier A-L, Mercado N, Ito K, El-Bahrawy M, Silver A et al. ( 2016 ) . Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer . Oncotarget vol. 7 , ( 28 ) 44505 - 44521 .

Suraweera N, Mouradov D, Li S, Jorissen RN, Hampson D, Ghosh A, Sengupta N, THAHA MA et al. ( 2016 ) . Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer . Oncotarget

Nolan A, Bray I, Stallings R, Silver A, Thomas W, Harvey B ( 2016 ) . Oestrogen and Hypoxia Modulate Gene Expression in Colorectal Cancer Cells Through Specific Microrna Regulation . IRISH JOURNAL OF MEDICAL SCIENCE vol. 185 , S34 - S34 .

Santoro V, Jia R, Thompson H, Nijhuis A, Jeffery R, Kiakos K, Silver AR, Hartley JA et al. ( 2015 ) . Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer . Journal of the National Cancer Institute vol. 108 , ( 6 )

Rigoni A, Bongiovanni L, Burocchi A, Sangaletti S, Danelli L, Guarnotta C, Lewis A, Rizzo A et al. ( 2015 ) . Mast Cells Infiltrating Inflamed or Transformed Gut Alternatively Sustain Mucosal Healing or Tumor Growth . Cancer Research vol. 75 , ( 18 ) 3760 - 3770 .

Lewis A, Mehta S, Hanna LN, Rogalski LA, Jeffery R, Nijhuis A, Kumagai T, Biancheri P et al. ( 2015 ) . Low Serum Levels of MicroRNA-19 Are Associated with a Stricturing Crohn's Disease Phenotype . Inflammatory Bowel Diseases vol. 21 , ( 8 ) 1926 - 1934 .

Jawad N, Johnson C, Butterworth E, Saeed I, Feakins R, Rodriguez-Justo M, McDonald S, Wright N et al. ( 2015 ) . OC-012 Do inflammatory polyps show features associated with the early stages of malignant progression? . Gut . vol. 64 ,

Urban BC, Collard TJ, Eagle CJ, Southern SL, Greenhough A, Hamdollah-Zadeh M, Ghosh A, Poulsom R et al. ( 2015 ) . BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling . Gut vol. 65 , ( 7 )

Lewis A, Nijhuis A, Mehta S, Kumagai T, Feakins R, Lindsay JO, Silver A ( 2015 ) . Intestinal Fibrosis in Crohn's Disease . Inflammatory Bowel Diseases vol. 21 , ( 5 ) 1141 - 1150 .

Felice C, Lewis A, Armuzzi A, Lindsay JO, Silver A ( 2015 ) . Review article: selective histone deacetylase isoforms as potential therapeutic targets in inflammatory bowel diseases . Aliment Pharmacol Ther vol. 41 , ( 1 ) 26 - 38 .

Davis H, Irshad S, Bansal M, Rafferty H, Boitsova T, Bardella C, Jaeger E, Lewis A et al. ( 2014 ) . Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche . Nature Medicine vol. 21 , ( 1 ) 62 - 70 .

Mehta S, Nijhuis A, Kumagai T, Lindsay J, Silver A ( 2014 ) . Defects in the adherens junction complex (E-cadherin/ β-catenin) in inflammatory bowel disease . Cell and Tissue Research vol. 360 , ( 3 ) 749 - 760 .

Nijhuis A, Biancheri P, Lewis A, Bishop CL, Giuffrida P, Chan C, Feakins R, Poulsom R et al. ( 2014 ) . In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts . Clin Sci (Lond) vol. 127 , ( 5 ) 341 - 350 .

MacFie TS, Poulsom R, Parker A, Warnes G, Boitsova T, Nijhuis A, Suraweera N, Poehlmann A et al. ( 2014 ) . DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid . Inflamm Bowel Dis vol. 20 , ( 3 ) 514 - 524 .

Poehlmann A, Reissig K, Schönfeld P, Walluscheck D, Schinlauer A, Hartig R, Lessel W, Guenther T et al. ( 2013 ) . Repeated H2 O2 exposure drives cell cycle progression in an in vitro model of ulcerative colitis . J Cell Mol Med vol. 17 , ( 12 ) 1619 - 1631 .

Ogunkolade BW, Jones TA, Aarum J, Szary J, Owen N, Ottaviani D, Mumin MA, Patel S et al. ( 2013 ) . BORIS/CTCFL is an RNA-binding protein that associates with polysomes . BMC Cell Biol vol. 14 ,

Poehlmann A, Reissig K, Just A, Walluscheck D, Hartig R, Schinlauer A, Lessel W, Guenther T et al. ( 2013 ) . Non-apoptotic function of caspases in a cellular model of hydrogen peroxide-associated colitis . J Cell Mol Med vol. 17 , ( 7 ) 901 - 913 .

Mehta SJ, Silver AR, Lindsay JO ( 2013 ) . Review article: strategies for the management of chronic unremitting ulcerative colitis . Aliment Pharmacol Ther vol. 38 , ( 2 ) 77 - 97 .

Biancheri P, Di Sabatino A, Nijhuis A, Lai C, Ghosh A, Macdonald TT, Lindsay J, Silver A et al. ( 2013 ) . OC.07.1 MICRO-RNA EXPRESSION PROFILING IDENTIFIES MIR-29B AS A RELEVANT PRO-FIBROGENIC FACTOR IN CROHN'S DISEASE INTESTINAL STRICTURES . Digestive and Liver Disease vol. 45 , s70 - s71 .

Ghosh A, Lai C, McDonald S, Suraweera N, Sengupta N, Propper D, Dorudi S, Silver A ( 2013 ) . HSP27 expression in primary colorectal cancers is dependent on mutation of KRAS and PI3K/AKT activation status and is independent of TP53 . Exp Mol Pathol vol. 94 , ( 1 ) 103 - 108 .

Biancheri P, Nijhuis A, Di Sabatino A, Lai C, Ghosh A, MacDonald TT, Corazza GR, Lindsay J et al. ( 2013 ) . P057 Micro-RNA expression profiling identifies miR-29b as a relevant pro-fibrogenic factor in Crohn's disease intestinal strictures . Journal of Crohn's and Colitis vol. 7 , ( Supplement_1 ) s32 - s32 .

Sengupta N, Yau C, Sakthianandeswaren A, Mouradov D, Gibbs P, Suraweera N, Cazier J, Polanco-Echeverry G et al. ( 2013 ) . Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion . Molecular Cancer Article 1 ,

Boitsova T, Rafferty H, Davis H, Bardella C, Gill P, East J, Tomlinson I, Chetty R et al. ( 2013 ) . BONE MORPHOGENETIC PROTEIN (BMP) PATHWAY DYSREGULATION SUBVERTS ONCOGENE INDUCED SENESCENCE MECHANISMS IN THE SERRATED PATHWAY OF TUMOURIGENESIS . GUT . vol. 62 , A200 - A200 .

Sengupta N, Yau C, Sakthianandeswaren A, Mouradov D, Gibbs P, Suraweera N, Cazier J-B, Polanco-Echeverry G et al. ( 2013 ) . Genome analysis of colorectal cancers in British Bangladeshis identifies early onset and a high prevalence of rbfox1 deletion compared to Caucasians . BRITISH JOURNAL OF SURGERY . vol. 100 , 7 - 7 .

Biancheri P, Nijhuis A, Lai C, Ghosh A, Feakins R, Chan C, Di Sabatino A, Corazza GR et al. ( 2012 ) . Tu1915 Differential MicroRNA Expression Profiles in Crohn's Disease Strictured Versus Non-Strictured Intestine . Gastroenterology vol. 142 , ( 5 ) s - 877 .

Silver A, Sengupta N, Propper D, Wilson P, Hagemann T, Patel A, Parker A, Ghosh A et al. ( 2012 ) . A distinct DNA methylation profile associated with microsatellite and chromosomal stable sporadic colorectal cancers . Int J Cancer vol. 130 , ( 5 ) 1082 - 1092 .

Macfie T, Parker A, Nijhuis A, Boitsova T, Suraweera N, Jeffery R, Poulsom R, Lindsay J et al. ( 2012 ) . 5-ASA ENHANCES <i>DUOX2</i> EXPRESSION IN ACTIVE ULCERATIVE COLITIS: A RISK FOR COLORECTAL CANCER? . GUT vol. 61 , A401 - A402 .

Jawad N, Graham T, Novelli M, Rodriguez-Justo M, Feakins R, Silver A, Wright N, McDonald S ( 2012 ) . ARE PSEUDOPOLYPS THE SOURCE OF TUMORIGENIC MUTATIONS IN ULCERATIVE COLITIS? . GUT vol. 61 , A236 - A236 .

Biancheri P, Nijhuis A, Lai C, Ghosh A, Feakins R, Chan C, Di Sabatino A, Corazza GR et al. ( 2012 ) . Differential MicroRNA Expression Profiles in Crohn's Disease Strictured Versus Non-Strictured Intestine . GASTROENTEROLOGY . vol. 142 , S877 - S877 .

Silver AR, Sengupta N, Propper D, Wilson P, Hagemann T, Patel A, Parker A, Ghosh A et al. ( 2012 ) . Genomic Profiling of Genetic Events in Colorectal Cancer: Identifying Subgroups with Distinct Phenotype-Genotype Associations . JOURNAL OF PATHOLOGY . vol. 226 , S6 - S6 .

Nijhuis A, Biancheri P, Lai C, Ghosh A, Boitsova T, Chan C, MacDonald T, Lindsay J et al. ( 2012 ) . MICRORNA EXPRESSION PROFILING IN STRICTURING CROHN'S DISEASE IDENTIFIES MIR-34A AS A FUNCTIONALLY RELEVANT INFLUENCE ON DISEASE PHENOTYPE . GUT vol. 61 , A167 - A168 .

Lai C, Robinson J, Clark S, Stamp G, Poulsom R, Silver A ( 2011 ) . Elevation of WNT5A expression in polyp formation in Lkb1+/- mice and Peutz-Jeghers syndrome . J Pathol vol. 223 , ( 5 ) 584 - 592 .

McDonald SL, Silver AR ( 2011 ) . On target? Strategies and progress in the development of therapies for colorectal cancer targeted against WNT signalling . COLORECTAL DIS vol. 13 , ( 4 ) 360 - 369 .

Patel HS, Silver AR, Levine T, Williams G, Northover JM ( 2010 ) . Human papillomavirus infection and anal dysplasia in renal transplant recipients . Br J Surg vol. 97 , ( 11 ) 1716 - 1721 .

Carvajal-Carmona LG, Silver A, Tomlinson IP ( 2010 ) . Molecular Genetics of Familial Adenomatous Polyposis . Hereditary Colorectal Cancer , Springer Nature

Sengupta N, MacFie TS, MacDonald TT, Pennington D, Silver AR ( 2010 ) . Cancer immunoediting and "spontaneous" tumor regression . Pathol Res Pract vol. 206 , ( 1 ) 1 - 8 .

Kuester D, Guenther T, Biesold S, Hartmann A, Bataille F, Ruemmele P, Peters B, Meyer F et al. ( 2010 ) . Aberrant methylation of DAPK in long-standing ulcerative colitis and ulcerative colitis-associated carcinoma . PATHOLOGY RESEARCH AND PRACTICE vol. 206 , ( 9 ) 616 - 624 .

Patel H, Silver A, Levine T, Williams G, Northover J ( 2010 ) . Prevalence of human papillomavirus types and risk factors for anal dysplasia in renal transplant patients . British Journal of Surgery vol. 97 , Article PMID:20730855 , 1716 - 1721 .

Elsaba TMA, Martinez-Pomares L, Robins AR, Crook S, Seth R, Jackson D, McCart A, Silver AR et al. ( 2010 ) . The Stem Cell Marker CD133 Associates with Enhanced Colony Formation and Cell Motility in Colorectal Cancer . PLOS ONE vol. 5 , ( 5 ) Article ARTN e10714 ,

Robinson J, Lai C, Martin A, Nye E, Tomlinson I, Silver A ( 2009 ) . Oral rapamycin reduces tumour burden and vascularization in Lkb1(+/-) mice . J Pathol vol. 219 , ( 1 ) 35 - 40 .

Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, Talbot IC, Glynne-Jones R et al. ( 2009 ) . Correction: Hypoxia-inducible factor-1α and -2α are expressed in most rectal cancers but only hypoxia-inducible factor-1α is associated with prognosis . British Journal of Cancer vol. 101 , ( 4 ) 742 - 742 .

McDonald SL, Silver A ( 2009 ) . The opposing roles of Wnt-5a in cancer . Br J Cancer vol. 101 , ( 2 ) 209 - 214 .

Silver ARJ, Masson WK, Breckon G, Cox R ( 2009 ) . Preliminary Molecular Studies on Two Chromosome 2 Encoded Genes, c-abl and β2M, in Radiation-induced Murine Myeloid Leukaemias . International Journal of Radiation Biology vol. 53 , ( 1 ) 57 - 63 .

Howarth K, Ranta S, Winter E, Teixeira A, Schaschl H, Harvey JJ, Rowan A, Jones A et al. ( 2009 ) . A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk . BMC MED GENET vol. 10 , Article 54 ,

Pollard P, Deheragoda M, Segditsas S, Lewis A, Rowan A, Howarth K, Willis L, Nye E et al. ( 2009 ) . The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression . Gastroenterology vol. 136 , ( 7 )

Elahi E, Suraweera N, Volikos E, Haines J, Brown N, Davidson G, Churchman M, Ilyas M et al. ( 2009 ) . Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice . PLoS One vol. 4 , ( 2 )

Rashid S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, Talbot IC, Glynee-Jones R et al. ( 2009 ) . Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis . Br J Cancer vol. 100 , ( 10 ) 1666 - 1673 .

Segditsas S, Sieber O, Deheragoda M, East P, Rowan A, Jeffery R, Nye E, Clark S et al. ( 2008 ) . Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice . HUM MOL GENET vol. 17 , ( 24 ) 3864 - 3875 .

Robinson J, Nye E, Stamp G, Silver A ( 2008 ) . Osteogenic tumours in Lkb1-deficient mice . Exp Mol Pathol vol. 85 , ( 3 ) 223 - 226 .

Vickaryous N, Polanco-Echeverry G, Morrow S, Suraweera N, Thomas H, Tomlinson I, Silver A ( 2008 ) . Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome . Br J Cancer vol. 99 , ( 10 ) 1726 - 1728 .

Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, Talbot IC, Glynne-Jones R et al. ( 2008 ) . Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer . Pathology - Research and Practice vol. 205 , ( 1 ) 1 - 9 .

McCart A, Haines J, Suraweera N, Tomlinson I, Silver A ( 2008 ) . Characterisation of an intestinal neoplasm modifier locus in Apc Min mice . European Journal of Cancer Supplements . vol. 6 ,

McCart AE, Vickaryous NK, Silver A ( 2008 ) . Apc mice: Models, modifiers and mutants . PATHOL RES PRACT vol. 204 , ( 7 ) 479 - 490 .

Sengupta N, Banerjea A, Suraweera N, Hammond L, Silver A, Dorudi S ( 2008 ) . Copy number and methylation analysis of microsatellite and chromosome stable colorectal cancers associated with poor outcome . DISEASES OF THE COLON & RECTUM . vol. 51 , 643 - 643 .

Sengupta N, Gill KA, MacFie TS, Lai CS, Suraweera N, Mcdonald S, Silver A ( 2008 ) . Management of colorectal cancer: a role for genetics in prevention and treatment? . Pathol Res Pract vol. 204 , ( 7 ) 469 - 477 .

Patel H, Polanco-Echeverry G, Segditsas S, Volikos E, McCart A, Lai C, Guenther T, Zaitoun A et al. ( 2007 ) . Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma . Int J Cancer vol. 121 , ( 12 ) 2668 - 2673 .

Tomlinson I, Webb E, Carvajal-Carmona L, Broderick P, Kemp Z, Spain S, Penegar S, Chandler I et al. ( 2007 ) . A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21 . NAT GENET vol. 39 , ( 8 ) 984 - 988 .

Carvajal-Carmona LG, Howarth KM, Lockett M, Polanco-Echeverry GM, Volikos E, Gorman M, Barclay E, Martin L et al. ( 2007 ) . Molecular classification and genetic pathways in hyperplastic polyposis syndrome . J Pathol vol. 212 , ( 4 ) 378 - 385 .

Suraweera N, Latchford A, McCart A, Rogers P, Spain S, Sieber O, Phillips R, Tomlinson I et al. ( 2007 ) . Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP . J MED GENET vol. 44 , ( 8 ) 541 - 544 .

Will O, Carvajal-Carmona LG, Gorman P, Howarth KM, Jones AM, Polanco-Echeverry GM, Chinaleong JA, Gunther T et al. ( 2007 ) . Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenorna phenotype without extraintestinal cancer . GASTROENTEROLOGY vol. 132 , ( 2 ) 527 - 530 .

Latchford A, Volikos E, Johnson V, Rogers P, Suraweera N, Tomlinson I, Phillips R, Silver A ( 2007 ) . APC mutations in FAP-associated desmoid tumours are non-random but not 'just right' . HUM MOL GENET vol. 16 , ( 1 ) 78 - 82 .

SILVER A, Northover J, Patel H ( 2007 ) . Anal cancer in renal transplant patients . Int J Colorectal Dis vol. 16 , ( 1 ) 1 - 5 .

Patel HS, Silver ARJ, Northover JMA ( 2007 ) . Anal cancer in renal transplant patients . Int J Colorectal Dis vol. 22 , ( 1 ) 1 - 5 .

Monahan KJ, Thomas HJ, Silver AR, Tomlinson IP, Phillips RK ( 2007 ) . Polyposis families without mutations have a less severe phenotype . GUT . vol. 56 , A24 - A24 .

Suraweera N, Haines J, McCart A, Rogers P, Latchford A, Coster M, Polanco-Echeverry G, Guenther T et al. ( 2006 ) . Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice . Hum Mol Genet vol. 15 , ( 23 ) 3429 - 3435 .

Suraweera N, Robinson J, Volikos E, Guenther T, Talbot I, Tomlinson I, Silver A ( 2006 ) . Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines . Int J Cancer vol. 119 , ( 8 ) 1837 - 1842 .

Sieber OM, Segditsas S, Knudsen AL, Zhang J, Luz J, Rowan AJ, Spain SL, Thirlwell C et al. ( 2006 ) . Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation . Gut vol. 55 , ( 10 ) 1440 - 1448 .

Kuester D, El-Rifai W, Guenther T, Hartmann A, Tannapfel A, Meyer F, Bohr URM, Biesold S et al. ( 2006 ) . Aberrant promoter methylation pattern in ulcerative colitis-associated carcinomas compared to sporadic colorectal carcinomas . MODERN PATHOLOGY . vol. 19 , 61 - 62 .

Kuester D, El-Rifai W, Guenther T, Hartmann A, Tannapfel A, Meyer F, Bohr URM, Biesold S et al. ( 2006 ) . Potential protective role of glutathione peroxidase-x3 in the inflammation-driven pathologv of ulcerative colitis and its frequent promoter hypermethylation in ulcerative colitis-associated carcinoma . MODERN PATHOLOGY . vol. 19 , 62 - 62 .

Silver A, Boultwood J, Breckon G, Masson W, Adam J, Shaw AR, Cox R ( 2006 ) . Interleukin‐1 Beta Gene Deregulation Associated With Chromosomal Rearrangement: A Candidate Initiating Event for Murine Radiation‐Myeloid Leukemogenesis? . Molecular Carcinogenesis vol. 2 , ( 4 ) 226 - 232 .

Silver A, George A, Masson W, Breckon G, Adam J, Cox R ( 2006 ) . DNA Methylation Changes in the IL‐I (2F) Chromosomal Region of Some Radiation‐Induced Acute Myeloid Leukaemias Carrying Chromosome 2 Rearrangements . Genes Chromosomes and Cancer vol. 3 , ( 5 ) 376 - 381 .

Bouffler S, Silver A, Papworth D, Coates J, Cox R ( 2006 ) . Murine radiation myeloid leukaemogenesis: Relationship between interstitial telomere‐like sequences and chromosome 2 fragile sites . Genes Chromosomes and Cancer vol. 6 , ( 2 ) 98 - 106 .

Tomlinson I, SILVER A, Volikos E, Robinson J, Aaltonen L, Aittomoki K, Mecklin J-P, Moeslein G et al. ( 2006 ) . Lkb1 exonic and whole-gene deletions are a common cause of Peutz-Jeghers syndrome . J Med Genet vol. 43 , ( 5 ) e18 - e18 .

McCart A, Latchford A, Volikos E, Rowan A, Tomlinson I, Silver A ( 2006 ) . A novel exon duplication event leading to a truncating germ-fine mutation of the APC gene in a Familial Adenomatous Polyposis family . FAM CANCER vol. 5 , ( 2 ) 205 - 208 .

Monahan KJ, Emmanouil V, Phillips RK, Huw TJ, Silver AR, Tomlinson IP ( 2006 ) . The genotype-phenotype relationship of polyposis families reveals clinically distinct subgroups . GASTROENTEROLOGY . vol. 130 , A152 - A152 .

Rowan A, Halford S, Gaasenbeek M, Kemp Z, Sieber O, Volikos E, Douglas E, Fiegler H et al. ( 2005 ) . Refining molecular analysis in the pathways of colorectal carcinogenesis . Clin Gastroenterol Hepatol vol. 3 , ( 11 ) 1115 - 1123 .

Johnson V, Lipton LR, Cummings C, Eftekhar Sadat AT, Izatt L, Hodgson SV, Talbot IC, Thomas HJW et al. ( 2005 ) . Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families . J Med Genet vol. 42 , ( 10 ) 756 - 762 .

Tomlinson I, SILVER A, Volikos E, Eftekhar Sadat A, Johnson V, Halford S, Truninger K, Talbot I et al. ( 2005 ) . Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in the hereditary non-polyposis colorectal cancer syndrome . Gut vol. 54 , 264 - 267 .

Bouffler S, Silver A, Cox R ( 2005 ) . The role of DNA repeats and associated secondary structures in genomic instability and neoplasia . BioEssays vol. 15 , ( 6 ) 409 - 412 .

Tomlinson I, SILVER A, Suraweera N, Wilding J, Cabuy E, Bodmer W, Sieber O, Slijepcevic P et al. ( 2005 ) . Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice . Proc. Natl. Acad. Sci. USA vol. 102 , 2868 - 2873 .

Tomlinson I, SILVER A, Robinson J, Rogers PA, Johnson V, Houlston RS, Thomas HJW, Evans DG et al. ( 2005 ) . Evidence for an association between compound heterozygosity for germ-line mutations in the haemochromatosis (HFE) gene and increased risk of colorectal cancer . Cancer Epidemiology Biomarkers and Prevention vol. 14 , 1460 - 1463 .

Tomlinson I, SILVER A, Suraweera N, Meijne E, Moody J, Carvajal-Carmona LG, Yoshida K, Pollard P et al. ( 2005 ) . Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia . Oncogene vol. 24 , 3678 - 3683 .

Sieber OM, Howarth KM, Thirlwell C, Rowan A, Mandir N, Goodlad RA, Gilkar A, Spencer-Dene B et al. ( 2004 ) . Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (Apc(Min/+)) mice . CANCER RES vol. 64 , ( 24 ) 8876 - 8881 .

Suraweera N, Zampeli E, Rogers P, Atkin W, Forbes A, Harbord M, Silver A ( 2004 ) . NCF1 (p47phox) and ncf1 pseudogenes are not associated with inflammatory bowel disease . Inflamm Bowel Dis vol. 10 , ( 6 ) 758 - 762 .

Kemp Z, Thirlwell C, Sieber O, Silver A, Tomlinson I ( 2004 ) . An update on the genetics of colorectal cancer . HUM MOL GENET vol. 13 , R177 - R185 .

Tomlinson I, SILVER A, Phillips R, Philp C, Bassett P, Neale K, Gallagher M, Sturt N ( 2004 ) . Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis (FAP) independent of the germline APC mutation . Gut vol. 53 , 1832 - 1836 .

SILVER A, Phillips R, Latchford A ( 2004 ) . Familial adenomatous polyposis associated desmoid disease . CME J Gastroenterology, Hepatology & Nutrition vol. 6 , ( 1 ) 22 - 27 .

SILVER A, Degg N, Weil M, Coster M, Ellender M, Cox R, Haines J, Edwards A et al. ( 2003 ) . Adenoma multiplicity in Irradiated ApcMin mice is modified by chromosome 16 segments from BALB/c . Cancer Research vol. 63 , 2361 - 2363 .

SILVER A, Cox R, Bouffler S ( 2002 ) . Mechanistic and genetic studies of radiation tumorigenesis in the mouse--implications for low dose risk estimation . Journal of Radiological Protection vol. 22 , ( 3A ) A11 - A16 .

SILVER A, Cox R, Edwards A, Haines J, Clark D, Moody J, Meijne E, Finnon R ( 2002 ) . A major breakpoint cluster domain in murine radiation-induced acute myeloid leukaemia . Mol. Carcinog. vol. 34 , 64 - 71 .

SILVER A, Moody J, Haines J, Meijne E, Edwards A, Newbold R, Parris C, Cox R et al. ( 2002 ) . Functional evidence from microcell-mediated chromosome transfer of myeloid leukaemia supressor genes on human chromosomes 7 and 11 . Genes, Chrom. & Cancer vol. 34 , 390 - 397 .

SILVER A, Edwards A, Spanjer S, Bouffler S, Wilding J, Moody J, Huiskamp R, Cox R et al. ( 2001 ) . Analysis of loss of heterozygosity in lymphoma and leukaemia arising in F1 hybrid mice locates a common region of chromosome 4 loss . Genes, Chrom. & Cancer vol. 31 , 373 - 381 .

SILVER A, Neville A, O'Hare M, Davies D, Alsop A, Jat P, Moody J, Atherton A et al. ( 2001 ) . Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells . Proc. Natl. Acad. Sci. USA vol. 98 , 646 - 651 .

SILVER A, Ullrich R, Long S, McCarthy M, Weil M, Yu Y, Okayasu R, Cox R et al. ( 2001 ) . Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA PKcs) gene . Cancer Research vol. 61 , 1820 - 1824 .

Finnon P, SILVER A, Bouffler S, Slijepcevic A, Wong H-P ( 2001 ) . Long but dysfunctional telomeres correlate with chromosomal radiosensitivity in a mouse AML cell line . Int. J. Rad Biol. vol. 77 , 1151 - 1162 .

Finnon P, Silver ARJ, Bouffler SD ( 2000 ) . Upregulation of telomerase activity by X-irradiation in mouse leukaemia cells is independent of Tert, Terc, Tnks and Myc transcription . Carcinogenesis vol. 21 , ( 4 ) 573 - 578 .

Hande P, Slijepcevic P, Silver A, Bouffler S, van Buul P, Bryant P, Lansdorp P ( 1999 ) . Elongated Telomeres inscidMice . Genomics vol. 56 , ( 2 ) 221 - 223 .

Russo I, Silver ARJ, Cuthbert AP, Griffin DK, Trott DA, Newbold RF ( 1999 ) . A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization . Oncogene vol. 17 , ( 26 ) 3417 - 3426 .

Clark DJ, Meijne EIM, Bouffler SD, Huiskamp R, Skidmore CJ, Cox R, Silver ARJ ( 1998 ) . Microsatellite analysis of recurrent chromosome 2 deletions in acute myeloid leukaemia induced by radiation in FI hybrid mice . Genes Chromosomes and Cancer vol. 16 , ( 4 ) 238 - 246 .

Meijne EIM, Silver ARJ, Bouffler SD, Morris DJ, van Kampen EW, Spanjer S, Huiskamp R, Cox R ( 1998 ) . Role of telomeric sequences in murine radiation‐induced myeloid leukaemia . Genes Chromosomes and Cancer vol. 16 , ( 4 ) 230 - 237 .

Wurzelmann JI, Silver A, Schreinemachers DM, Sandler RS, Everson RB ( 1996 ) . Iron intake and the risk of colorectal cancer . Cancer Epidemiology Biomarkers & Prevention vol. 5 , ( 7 ) 503 - 507 .

Silver A, Bouffler S, Finnon P, Rance E, Morris D, Cox (INVITED) R ( 1994 ) . Site-Specific Chromosome Damage and Myeloid Leukaemogenesis in the CBA Mouse . Radiation Protection Dosimetry . vol. 52 , 461 - 464 .

Silver A, Cox R ( 1993 ) . Telomere-like DNA polymorphisms associated with genetic predisposition to acute myeloid leukemia in irradiated CBA mice . Proceedings of the National Academy of Sciences of the United States of America vol. 90 , ( 4 ) 1407 - 1410 .

Cox R, Breckon G, Silver ARJ, Mason WK, George AM ( 1991 ) . Chromosomal changes: Radiation sensitive sites on chromosome 2 and their role in radiation myeloid leukaemogenesis in the mouse . Radiation and Environmental Biophysics vol. 30 , ( 3 ) 177 - 179 .

BRECKON G, SILVER A, COX R ( 1991 ) . Radiation-induced Chromosome 2 Breakage and the Initiation of Murine Radiation Acute Myeloid Leukaemogenesis . Journal of Radiation Research vol. 32 , ( SUPPLEMENT2 ) 248 - 256 .

Silver ARJ, Masson WK, George AM, Adam J, Cox R ( 1990 ) . TheIL-1α and β genes are closely linked (<70 kb) on mouse chromosome 2 . Somatic Cell and Molecular Genetics vol. 16 , ( 6 ) 549 - 556 .

Silver AR, Breckon G, Masson WK, Adam J, Boultwood J, Cox R ( 1990 ) . Radiation-induced chromosome 2 rearrangement and initiation of murine acute myeloid leukemia . Radiation Research . vol. 121 , 233 - 234 .

Greaves MF, Morgenstern GR, Lord BI, Priest ND, Baverstock KF, Humphreys ER, Loutit JF, Major ER et al. ( 1988 ) . Meeting report. Forum on alpha-emitters in bone and leukaemia . International Journal of Radiation Biology vol. 53 , ( 3 ) 521 - 539 .

O'Neill P, Jenkins TC, Stratford IJ, Silver AR, Ahmed I, McNeil SS, Fielden EM, Adams GE ( 1987 ) . Mechanism of action of some bioreducible 2-nitroimidazoles: comparison of in vitro cytotoxicity and ability to induce DNA strand breakage . Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics vol. 1 , ( 4 ) 271 - 280 .

Silver ARJ, Mcneil SS, O'Neill P, Jenkins TC, Ahmed I ( 1986 ) . Induction of DNA strand breaks by reduced nitroimidazoles Implications for DNA base damage . Biochemical Pharmacology vol. 35 , ( 22 ) 3923 - 3928 .

Walling JM, Stratford IJ, Adams GE, Silver ARJ, Ahmed I, Jenkins TC, Fielden EM ( 1986 ) . Studies on the mechanisms of the radiosensitizing and cytotoxic properties of RSU-1069 and its analogues . International Journal of Radiation Oncology • Biology • Physics vol. 12 , ( 7 ) 1083 - 1086 .

Silver ARJ, O'Neill P, Jenkins TC, McNeil SS ( 1986 ) . The phosphate-group of dna as a potential target for RSU-1069, a nitroimidazole-aziridine radiosensitizer . International Journal of Radiation Oncology • Biology • Physics vol. 12 , ( 7 ) 1203 - 1206 .

Silver ARJ, O'Neill P ( 1986 ) . Interaction of the aziridine moiety of RSU-1069 with nucleotides and inorganic phosphate Implications for alkylation of DNA . Biochemical Pharmacology vol. 35 , ( 7 ) 1107 - 1112 .

Stratford IJ, Walling JM, Silver AR ( 1986 ) . The differential cytotoxicity of RSU 1069: Cell survival studies indicating interaction with DNA as a possible mode of action . British Journal of Cancer vol. 53 , ( 3 ) 339 - 344 .

Stratford IJ, O'Neill P, Sheldon PW, Silver ARJ, Walling JM, Adams GE ( 1986 ) . RSU 1069, a nitroimidazole containing an aziridine group Bioreduction greatly increases cytotoxicity under hypoxic conditions . Biochemical Pharmacology vol. 35 , ( 1 ) 105 - 109 .

Silver ARJ, O'Neill P, Jenkins TC ( 1985 ) . Induction of DNA strand breaks by RSU-1069, a nitroimidazole-aziridine radiosensitizer Role of binding of both unreduced and radiation-reduced forms to DNA, in vitro . Biochemical Pharmacology vol. 34 , ( 19 ) 3537 - 3542 .