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Research

Publications: Dr Gareth Pryce

Marta M, Baker D, Creeke P, Pryce G, Gnanapavan S, Giovannoni G ( 2021 ) . Antigen-specific tolerization in human autoimmunity: Inhibition of interferon-beta1a anti-drug antibodies in multiple sclerosis: A case report . Multiple Sclerosis and Related Disorders vol. 56 ,
Baker D, Roberts CAK, Pryce G, Kang AS, Marta M, Reyes S, Schmierer K, Giovannoni G et al. ( 2020 ) . COVID-19 vaccine-readiness for anti-CD20-depleting therapy in autoimmune diseases . Clinical and Experimental Immunology vol. 202 , ( 2 ) 149 - 161 .
Saxena G, Moore JM, Jones M, Pryce G, Ali L, Leisegang GR, Vijay V, Loveless S et al. ( 2020 ) . Detecting and predicting neutralization of alemtuzumab responses in MS . Neurology(R) neuroimmunology & neuroinflammation vol. 7 , ( 4 )
Baker D ( 2020 ) . Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis . Acta Neuropathologica
Baker D, Pryce G, James LK, Marta M, Schmierer K ( 2020 ) . The ocrelizumab phase II extension trial suggests the potential to improve the risk:benefit balance in multiple sclerosis . Multiple Sclerosis and Related Disorders Article 102279 , 102279 - 102279 .
Baker D, Ali L, SAXENA G, Pryce G, Jones M, Schmierer K, Giovannoni G, Gnanapavan S et al. ( 2020 ) . The irony of humanization: Alemtuzumab the first, but one of the most immunogenic, humanized monoclonal antibodies . Frontiers in Immunology vol. 11 , ( 124 )
Baker D, Pryce G, James LK, Schmierer K, Giovannoni G ( 2020 ) . Failed B cell survival factor trials support the importance of memory B cells in multiple sclerosis . European Journal of Neurology vol. 27 , ( 2 ) 221 - 228 .
Baker D, Pryce G, James LK, Marta M, Schmierer K ( 2020 ) . The ocrelizumab phase II extension trial suggests the potential to improve the risk:benefit balance in multiple sclerosis . Multiple Sclerosis and Related Disorders2020.01.09.20016774 - 2020.01.09.20016774 .
Baker D, Pryce G, Herrod SS, Schmierer K ( 2019 ) . Potential mechanisms of action related to the efficacy and safety of cladribine . Multiple Sclerosis and Related Disorders vol. 30 , 176 - 186 .
Pryce G, Baker D ( 2019 ) . CHAPTER 11 Cannabinoids as a Therapeutic Approach in Multiple Sclerosis . Emerging Drugs and Targets for Multiple Sclerosis ,
Pryce G, Baker D ( 2019 ) . CHAPTER 11: Cannabinoids as a Therapeutic Approach in Multiple Sclerosis . RSC Drug Discovery Series , vol. 2019-January ,
BAKER D, GIOVANNONI G, PRYCE G, AMOR S, SCHMIERER K ( 2018 ) . Learning from other autoimmunities to understand targeting of B cells to control multiple sclerosis . Brain
BO XUENONG, GUSHCHINA S, PRYCE G, YIP P, WU D, PALLIER P, GIOVANNONI G, BAKER D ( 2018 ) . Increased expression of colony‐stimulating factor‐1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and neuronal loss . Glia vol. 66 , ( 10 ) 2108 - 2125 .
BAKER D, Pryce, G ( 2018 ) . Oligoclonal bands in multiple sclerosis; functional significance and therapeutic implications. Does the specificity matter? . multiple sclerosis and related disorders
Dubuisson N, Baker D, Kang AS, Pryce G, Marta M, Visser LH, Hofmann WE, Gnanapavan S et al. ( 2018 ) . Alemtuzumab depletion failure can occur in multiple sclerosis . Immunology vol. 154 , ( 2 ) 253 - 260 .
Schmierer K, Marta M, Pryce G, Giovannoni G, Baker D ( 2017 ) . PO150 Memory b cells are key for immunotherapy in multiple sclerosis . Journal of Neurology Neurosurgery & Psychiatry . vol. 88 , a52 - a52 .
Pryce G, Baker D ( 2017 ) . Antidote to cannabinoid intoxication: the CB<inf>1</inf> receptor inverse agonist, AM251, reverses hypothermic effects of the CB<inf>1</inf> receptor agonist, CB-13, in mice . British Journal of Pharmacology vol. 174 , ( 21 ) 3790 - 3794 .
Pryce G, Sisay S, Petrova N, Giovannonni G, Selwood DL, Baker D ( 2017 ) . Neuroprotection in an experimental model of multiple sclerosis, via opening of big conductance, calcium-activated potassium channels . MULTIPLE SCLEROSIS JOURNAL . vol. 23 , 621 - 622 .
BAKER D ( 2017 ) . Big conductance calcium-activated potassium channel openers control spasticity without sedation . British Journal of Pharmcology
BAKER D, Giovannoni G, Sefia E, Pryce G, Meier U ( 2017 ) . Depletion of CD20 B cells fails to inhibit relapsing mouse experimental autoimmune encephalomyelitis . Multiple Sclerosis and Related Disorders
von Kutzleben S, Pryce G, Giovannoni G, Baker D ( 2017 ) . Depletion of CD52-positive cells inhibits the development of central nervous system autoimmune disease, but deletes an immunetolerance promoting CD8 t-cell population. Implications for secondary autoimmunity of alemtuzumab in multiple sclerosis . Immunology vol. 150 , ( 4 ) 444 - 455 .
Baker D, Marta M, Pryce G, Giovannoni G, Schmierer K ( 2017 ) . Memory B Cells are Major Targets for Effective Immunotherapy in Relapsing Multiple Sclerosis . EBioMedicine vol. 16 , 41 - 50 .
Williams T, Pryce G, Giovannoni G, Selwood D, Baker D ( 2016 ) . VSN16R-A NOVEL TREATMENT FOR SPASTICITY IN EXPERIMENTAL MULTIPLE SCLEROSIS . vol. 87 , is. 12 , Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob java.io.Serializable ,
Peferoen LAN, Breur M, van de Berg S, Peferoen-Baert R, Boddeke EHWGM, van der Valk P, Pryce G, van Noort JM et al. ( 2016 ) . Ageing and recurrent episodes of neuroinflammation promote progressive experimental autoimmune encephalomyelitis in Biozzi ABH mice . Immunology vol. 149 , ( 2 ) 146 - 156 .
Sevastou I, Pryce G, Baker D, Selwood DL ( 2016 ) . Characterisation of Transcriptional Changes in the Spinal Cord of the Progressive Experimental Autoimmune Encephalomyelitis Biozzi ABH Mouse Model by RNA Sequencing . PLOS ONE vol. 11 , ( 6 ) e0157754 - e0157754 .
Ummenthum K, Peferoen LAN, Finardi A, Baker D, Pryce G, Mantovani A, Bsibsi M, Bottazzi B et al. ( 2016 ) . Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease . European Journal of Immunology vol. 46 , ( 3 ) 701 - 711 .
Warne J, Pryce G, Hill JM, Shi X, Lennerås F, Puentes F, Kip M, Hilditch L et al. ( 2016 ) . Selective inhibition of the mitochondrial permeability transition pore protects against neurodegeneration in experimental multiple sclerosis . Journal of Biological Chemistry vol. 291 , ( 9 ) 4356 - 4373 .
Pryce G, Riddall DR, Selwood DL, Giovannoni G, Baker D ( 2015 ) . Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids . Journal of Neuroimmune Pharmacology vol. 10 , ( 2 ) 281 - 292 .
Pryce G, Baker D ( 2015 ) . Endocannabinoids in multiple sclerosis and amyotrophic lateral sclerosis . vol. 231 , 213 - 231 .
Pryce G, Baker D ( 2015 ) . Cannabinoids fail to show evidence of slowing down the progression of multiple sclerosis . Evidence-Based Medicine vol. 20 , ( 4 )
Vainchtein I, Vinet J, Al-Izki S, Pryce G, Grit C, Brouwer N, Amor S, Baker D et al. ( 2015 ) . Microglia are involved in apoptotic clearance during chronic-relapsing EAE . GLIA . vol. 63 , E353 - E353 .
Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, Van Der Pol SMA, Hirst MC et al. ( 2015 ) . Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation . Journal of Cerebral Blood Flow and Metabolism vol. 35 , ( 3 ) 412 - 423 .
Pryce G, Riddall DR, Selwood DL, Giovannoni G, Baker D ( 2014 ) . Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids . Journal of Neuroimmune Pharmacology
Von Kutzleben S, Pryce G, Chretien N, Turner M, Siders W, Baker D ( 2014 ) . Inhibition of relapsing experimental autoimmune encephalomyelitis in Biozzi ABH mice using a mouse CD52-specific monoclonal antibody . Journal of Neuroimmunology . vol. 275 ,
Lopez-Ramirez MA, Wu D, Pryce G, Simpson JE, Reijerkerk A, King-Robson J, Kay O, de Vries HE et al. ( 2014 ) . MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation . FASEB J vol. 28 , ( 6 ) 2551 - 2565 .
Hampton DW, Serio A, Pryce G, Al-Izki S, Franklin RJM, Giovannoni G, Baker D, Chandran S ( 2014 ) . Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis . Acta Neuropathologica Communications vol. 2 , ( 1 )
Pryce G, Visintin C, Ramagopalan SV, Al-Izki S, De Faveri LE, Nuamah RA, Mein CA, Montpetit A et al. ( 2014 ) . Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists . FASEB J vol. 28 , ( 1 ) 117 - 130 .
Mullen L, Rigby A, Sclanders M, Adams G, Mittal G, Colston J, Fatah R, Subang C et al. ( 2014 ) . Latency can be conferred to a variety of cytokines by fusion with latency-associated peptide from TGF-β . Expert Opin Drug Deliv vol. 11 , ( 1 ) 5 - 16 .
Al-Izki S, Pryce G, Hankey DJR, Lidster K, von Kutzleben SM, Browne L, Clutterbuck L, Posada C et al. ( 2014 ) . Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis . Brain vol. 137 , ( Pt 1 ) 92 - 108 .
Pryce G, Cabranes A, Fernández-Ruiz J, Bisogno T, Di Marzo V, Long JZ, Cravatt BF, Giovannoni G et al. ( 2013 ) . Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors . Mult Scler vol. 19 , ( 14 ) 1896 - 1904 .
Puentes F, van der Star BJ, Victor M, Kipp M, Beyer C, Peferoen-Baert R, Ummenthum K, Pryce G et al. ( 2013 ) . Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis . Journal of Neuroinflammation vol. 10 ,
Baker D, Lidster K, Al-Izki S, Pryce G, Giovannoni G ( 2013 ) . Animal models of progressive disability in MS . IRISH JOURNAL OF MEDICAL SCIENCE vol. 182 , S5 - S6 .
Sisay S, Pryce G, Jackson SJ, Tanner C, Ross RA, Michael GJ, Selwood DL, Giovannoni G et al. ( 2013 ) . Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis . PLoS One vol. 8 , ( 10 )
Lopez-Ramirez MA, Wu D, Pryce G, Simpson JE, Reijerkerk A, King-Robson J, de Vries HE, Hirst MC et al. ( 2012 ) . Endothelial miR-155 promotes blood brain barrier dysfunction in neuroinflammation . JOURNAL OF NEUROIMMUNOLOGY . vol. 253 , 3 - 4 .
Pryce G, Baker D ( 2012 ) . Potential control of multiple sclerosis by cannabis and the endocannabinoid system . CNS Neurol Disord Drug Targets vol. 11 , ( 5 ) 624 - 641 .
Gnanapavan S, Grant D, Pryce G, Jackson S, Baker D, Giovannoni G ( 2012 ) . Neurofilament a biomarker of neurodegeneration in autoimmune encephalomyelitis . Autoimmunity vol. 45 , ( 4 ) 298 - 303 .
Baker D, Pryce G, Jackson SJ, Bolton C, Giovannoni G ( 2012 ) . The biology that underpins the therapeutic potential of cannabis-based medicines for the control of spasticity in multiple sclerosis . Multiple Sclerosis and Related Disorders vol. 1 , ( 2 ) 64 - 75 .
Hilliard A, Stott C, Wright S, Guy G, Pryce G, Al-Izki S, Bolton C, Giovannoni G ( 2012 ) . Evaluation of the Effects of Sativex (THC BDS: CBD BDS) on Inhibition of Spasticity in a Chronic Relapsing Experimental Allergic Autoimmune Encephalomyelitis: A Model of Multiple Sclerosis . ISRN Neurol vol. 2012 ,
Al-Izki S, Pryce G, O'Neill JK, Butter C, Giovannoni G, Amor S, Baker D ( 2012 ) . Practical guide to the induction of relapsing progressive experimental autoimmune encephalomyelitis in the Biozzi ABH mouse . Multiple Sclerosis and Related Disorders vol. 1 , ( 1 ) 29 - 38 .
Graves RS, Pryce G, Cabranes A, Fernandez-Ruiz J, Bisogno T, Di Marzo V, Cravatt BF, Michael GJ et al. ( 2011 ) . Fatty acid amide hydrolase as a target for neuroprotection . MULTIPLE SCLEROSIS JOURNAL vol. 17 , S431 - S431 .
Al-Izki S, Pryce G, Amor S, Gerritsen W, Garthwaite J, Giovannoni G, Selwood DL, Baker D ( 2011 ) . Selective targeting of neuroprotection to MS lesions: sodium channel blockers in experimental autoimmune encephalomyelitis . MULTIPLE SCLEROSIS JOURNAL vol. 17 , S209 - S210 .
Pryce G, Visintin C, Lutz B, Marsicano G, Giovannoni G, Selwood DL, Baker D ( 2011 ) . Selective targeting of spasticity by CNS-excluded cannabinoids . MULTIPLE SCLEROSIS JOURNAL vol. 17 , S247 - S247 .
Baker D, Pryce G, Visintin C, Pertwee RG, Tanner C, Ross R, Irving A, Sisay S et al. ( 2011 ) . VSN16R a novel agent for the control of spasticity . MULTIPLE SCLEROSIS JOURNAL vol. 17 , S243 - S243 .
Ayoub SS, Pryce G, Seed MP, Bolton C, Flower RJ, Baker D ( 2011 ) . Paracetamol-induced hypothermia is independent of cannabinoids and transient receptor potential vanilloid-1 and is not mediated by AM404 . Drug Metab Dispos vol. 39 , ( 9 ) 1689 - 1695 .
Al-Izki S, Pryce G, Jackson SJ, Giovannoni G, Baker D ( 2011 ) . Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis . Mult Scler vol. 17 , ( 8 ) 939 - 948 .
Al-Izki S, Pryce G, Giovannoni G, Baker D ( 2009 ) . Evaluating potential therapies for bladder dysfunction in a mouse model of multiple sclerosis with high-resolution ultrasonography . Mult Scler vol. 15 , ( 7 ) 795 - 801 .
Hampton DW, Anderson J, Pryce G, Irvine KA, Giovannoni G, Fawcett JW, Compston A, Franklin RJM et al. ( 2008 ) . An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss . J NEUROIMMUNOL vol. 201 , 200 - 211 .
Jackson S, Al-Izik S, Pryce G, Giovannoni G, Baker D ( 2008 ) . Fingolimod reduces axonal loss in relapsing secondary progressive experimental autoimmune encephalomyelitis . MULTIPLE SCLEROSIS . vol. 14 , S80 - S81 .
Parkes H, Shorter S, So PW, Baker D, Pryce G, Giovannoni G, Schmierer K ( 2008 ) . High resolution 1H nuclear magnetic resonance spectroscopic-based metabolomic urine analysis of experimental autoimmune encephalitis, a model disease of multiple sclerosis . MULTIPLE SCLEROSIS . vol. 14 , S86 - S87 .
Al-Izki S, Pryce G, Jackson S, Giovannoni G, Baker D ( 2008 ) . Neuroprotective effects of omega-3 fatty acids in a mouse model of multiple sclerosis . JOURNAL OF NEUROIMMUNOLOGY . vol. 197 , 173 - 173 .
Anderson JM, Hampton DW, Patani R, Pryce G, Crowther RA, Reynolds R, Franklin RJM, Giovannoni G et al. ( 2008 ) . Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis . BRAIN vol. 131 , 1736 - 1748 .
East E, Gverić D, Baker D, Pryce G, Lijnen HR, Cuzner ML ( 2008 ) . Chronic relapsing experimental allergic encephalomyelitis (CREAE) in plasminogen activator inhibitor-1 knockout mice: the effect of fibrinolysis during neuroinflammation . Neuropathol Appl Neurobiol vol. 34 , ( 2 ) 216 - 230 .
Croxford JL, Pryce G, Jackson SJ, Ledent C, Giovannoni G, Pertwee RG, Yamamura T, Baker D ( 2008 ) . Cannabinoid-mediated neuroprotection, not immuno suppression, may be more relevant to multiple sclerosis . J NEUROIMMUNOL vol. 193 , ( 1-2 ) 120 - 129 .
Pryce G, Jackson SJ, Baker D ( 2008 ) . Cannabinoids for the control of multiple sclerosis . Cannabinoids and the Brain ,
Baker D, Pryce G ( 2008 ) . The endocannabinoid system and multiple sclerosis . Curr Pharm Des vol. 14 , ( 23 ) 2326 - 2336 .
Baker D, Jackson SJ, Pryce G ( 2007 ) . Cannabinoid control of neuroinflammation related to multiple sclerosis . Br J Pharmacol vol. 152 , ( 5 ) 649 - 654 .
Maresz K, Pryce G, Ponomarev ED, Marsicano G, Croxford JL, Shriver LP, Ledent C, Cheng XD et al. ( 2007 ) . Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells . NAT MED vol. 13 , ( 4 ) 492 - 497 .
Pryce G, Baker D ( 2007 ) . Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors . BRIT J PHARMACOL vol. 150 , ( 4 ) 519 - 525 .
Baker D, Croxford JL, Pryce G, Jackson SM, Ledent C, Marsicano G, Lutz B, Giovannoni G et al. ( 2006 ) . Cannabinoid-mediated immunosuppression in experimental allergic encephalomyelitis . JOURNAL OF NEUROIMMUNOLOGY . vol. 178 , 90 - 91 .
Cabranes A, Pryce G, Baker D, Fernandez-Ruiz J ( 2006 ) . Changes in CB1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis mice . BRAIN RES vol. 1107 , 199 - 205 .
Bilsland LG, Dick JRT, Pryce G, Petrosino S, Di Marzo V, Baker D, Greensmith L ( 2006 ) . Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice . FASEB J vol. 20 , ( 7 ) 1003 - + .
Baker D, Pryce G, Croxford JL, Yamamura T ( 2006 ) . Cannabinoid-mediated immunosuppression in experimental allergic encephalomyelitits . CURRENT TOPICS IN NEUROIMMUNOLOGY . Editors: Tabira, T, Yamamura, T, Kira, J , 109 - 116 .
Cristino L, De Petrocellis L, Pryce G, Baker D, Guglielmotti V, Di Marzo V ( 2006 ) . Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain . NEUROSCIENCE vol. 139 , ( 4 ) 1405 - 1415 .
Baker D, Pryce G, Davies WL, Hiley CR ( 2006 ) . In silico patent searching reveals a new cannabinoid receptor . Trends Pharmacol Sci vol. 27 , ( 1 ) 1 - 4 .
Ligresti A, Cascio MG, Pryce G, Kulasegram S, Beletskaya I, De Petrocellis L, Saha B, Mahadevan A et al. ( 2006 ) . New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis . BRIT J PHARMACOL vol. 147 , ( 1 ) 83 - 91 .
de Lago E, Fernandez-Ruiz J, Ortega-Gutierrez S, Cabranes A, Pryce G, Baker D, Lopez-Rodriguez M, Ramos JA ( 2006 ) . UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders . EUR NEUROPSYCHOPHARM vol. 16 , ( 1 ) 7 - 18 .
Heijmans N, Smith PA, Morris-Downes MM, Pryce G, Baker D, Donaldson AVJ, 't Hart B, Amor S ( 2005 ) . Encephalitogenic and tolerogenic potential of altered peptide ligands of MOG and PLP in Biozzi ABH mice . J NEUROIMMUNOL vol. 167 , ( 1-2 ) 23 - 33 .
East E, Baker D, Pryce G, Lijnen HR, Cuzner ML, Gverić D ( 2005 ) . A role for the plasminogen activator system in inflammation and neurodegeneration in the central nervous system during experimental allergic encephalomyelitis . Am J Pathol vol. 167 , ( 2 ) 545 - 554 .
Pryce G, O'Neill JK, Croxford JL, Amor S, Hankey DJ, East E, Giovannoni G, Baker D ( 2005 ) . Autoimmune tolerance eliminates relapses but fails to halt progression in a model of multiple sclerosis . J NEUROIMMUNOL vol. 165 , ( 1-2 ) 41 - 52 .
Jackson SJ, Pryce G, Diemel LT, Cuzner ML, Baker D ( 2005 ) . Cannabinoid-receptor 1 null mice are susceptible to neurofilament damage and caspase 3 activation . Neuroscience vol. 134 , ( 1 ) 261 - 268 .
Smith PA, Morris-Downes M, Heijmans N, Pryce G, Arter E, O'Neill JK, 't Hart B, Baker D et al. ( 2005 ) . Epitope spread is not critical for the relapse and progression of MOG 8-21 induced EAE in Biozzi ABH mice . J NEUROIMMUNOL vol. 164 , ( 1-2 ) 76 - 84 .
Jackson SJ, Diemel LT, Pryce G, Baker D ( 2005 ) . Cannabinoids and neuroprotection in CNS inflammatory disease . J Neurol Sci . vol. 233 , 21 - 25 .
Pryce G, Baker D ( 2005 ) . Emerging properties of cannabinoid medicines in management of multiple sclerosis . Trends Neurosci vol. 28 , ( 5 ) 272 - 276 .
Gegg ME, Harry R, Hankey D, Zambarakji H, Pryce G, Baker D, Adamson P, Calder V et al. ( 2005 ) . Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction . J IMMUNOL vol. 174 , ( 4 ) 2327 - 2335 .
Pryce G, Jackson SM, Hankey DRJ, Giovannoni G, Baker D ( 2004 ) . Cannabinoids are neuroprotective: dissociation of true neuroprotection from protection secondary to immunosuppression . JOURNAL OF NEUROIMMUNOLOGY . vol. 154 , 78 - 78 .
Pryce G, O'Neill JK, Hankey DRJ, East E, Amor S, Giovannoni G, Baker B ( 2004 ) . Immunological tolerance that eliminates relapses, fails to halt secondary progression in a chronic multiple sclerosis model . JOURNAL OF NEUROIMMUNOLOGY . vol. 154 , 62 - 62 .
Baker D, Pryce G ( 2004 ) . The potential role of the endocannabinoid system in the control of multiple scleorsis . Current Medicinal Chemistry - Central Nervous System Agents vol. 4 , ( 3 ) 195 - 202 .
East E, Baker D, Pryce G, Cuzner ML, Gveric D ( 2004 ) . The role of plasminogen activators in experimental allergic encephalomyelitis: inflammation and axonal pathology . JOURNAL OF NEUROIMMUNOLOGY . vol. 154 , 167 - 167 .
de Lago E, Ligresti A, Ortar G, Morera E, Cabranes A, Pryce G, Bifulco M, Baker D et al. ( 2004 ) . In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake . EUR J PHARMACOL vol. 484 , ( 2-3 ) 249 - 257 .
Wilkinson JD, Whalley BJ, Baker D, Pryce G, Constanti A, Gibbons S, Williamson EM ( 2003 ) . Medicinal cannabis: is Delta(9)-tetrahydrocannabinol necessary for all its effects? . J PHARM PHARMACOL vol. 55 , ( 12 ) 1687 - 1694 .
Pryce G, Ahmed Z, Hankey DJR, Jackson SJ, Croxford JL, Pocock JM, Ledent C, Petzold A et al. ( 2003 ) . Cannabinoids inhibit neurodegeneration in models of multiple sclerosis . BRAIN vol. 126 , 2191 - 2202 .
East E, Baker D, Pryce GM, Cuzner ML, Gveric D ( 2003 ) . The role of plasminogen activators in experimental allergic encephalomyelitis . GLIA . 40 - 40 .
Greenwood J, Walters CE, Pryce G, Kanuga N, Beraud E, Baker D, Adamson P ( 2003 ) . Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis . FASEB J vol. 17 , ( 8 ) 905 - 907 .
Pryce G, Giovannoni G, Baker D ( 2003 ) . Mifepristone or inhibition of 11 beta-hydroxylase activity potentiates the sedating effects of the cannabinoid receptor-1 agonist Delta(9)-tetrahydrocannabinol in mice . NEUROSCI LETT vol. 341 , ( 2 ) 164 - 166 .
Petzold A, Baker D, Pryce G, Keir G, Thompson EJ, Giovannoni G ( 2003 ) . Quantification of neurodegeneration by measurement of brain-specific proteins . J Neuroimmunol vol. 138 , ( 1-2 ) 45 - 48 .
Baker D, Pryce G, Giovannoni G, Thompson AJ ( 2003 ) . The therapeutic potential of cannabis . LANCET NEUROL vol. 2 , ( 5 ) 291 - 298 .
Baker D, Pryce G ( 2003 ) . The therapeutic potential of cannabis in multiple sclerosis . Expert Opin Investig Drugs vol. 12 , ( 4 ) 561 - 567 .
Ahmed Z, Doward AI, Pryce G, Taylor DL, Pocock JM, Leonard JP, Baker D, Cuzner ML ( 2002 ) . A role for caspase-1 and-3 in the pathology of experimental allergic encephalomyelitis - Inflammation versus degeneration . AM J PATHOL vol. 161 , ( 5 ) 1577 - 1586 .
Walters CE, Pryce G, Hankey DJR, Sebti SM, Hamilton AD, Baker D, Greenwood J, Adamson P ( 2002 ) . Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis . J IMMUNOL vol. 168 , ( 8 ) 4087 - 4094 .
Brooks JW, Pryce G, Bisogno T, Jaggar SI, Hankey DJR, Brown P, Bridges D, Ledent C et al. ( 2002 ) . Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB1/CB2 receptors . EUR J PHARMACOL vol. 439 , ( 1-3 ) 83 - 92 .
Ahmed Z, Gveric D, Pryce G, Baker D, Leonard JP, Cuzner ML, Diemel LT ( 2001 ) . Myelin/axonal pathology in interleukin-12 induced serial relapses of experimental allergic encephalomyelitis in the Lewis rat . Am J Pathol vol. 158 , ( 6 ) 2127 - 2138 .
Baker D, Pryce G, Croxford JL, Brown P, Pertwee RG, Makriyannis A, Khanolkar A, Layward L et al. ( 2001 ) . Endocannabinoids control spasticity in a multiple sclerosis model . FASEB J vol. 15 , ( 2 ) 300 - 302 .
Baker D, Pryce G, Ludovic Croxford J, Brown P, Pertwee RG, Huffman JW, Layward L ( 2000 ) . Cannabinoids control spasticity and tremor in a multiple sclerosis model . Nature vol. 404 , ( 6773 ) 84 - 87 .
Pryce G, Male D, Campbell I, Greenwood J ( 1997 ) . Factors controlling T-cell migration across rat cerebral endothelium in vitro . Journal of Neuroimmunology vol. 75 , ( 1-2 ) 84 - 94 .
Greenwood J, Pryce G, Devine L, Male DK, Dos Santos WLC, Calder VL, Adamson P ( 1996 ) . SV40 large T immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics . Journal of Neuroimmunology vol. 71 , ( 1-2 ) 51 - 63 .
Male D, Rahman J, Pryce G, Tamatani T, Miyasaka M ( 1994 ) . Lymphocyte migration into the CNS modelled in vitro: Roles of LFA-1, ICAM- 1 and VLA-4 . Immunology vol. 81 , ( 3 ) 366 - 372 .
Pryce G, Santos W, Male D ( 1994 ) . An assay for the analysis of lymphocyte migration across cerebral endothelium in vitro . Journal of Immunological Methods vol. 167 , ( 1-2 ) 55 - 63 .
Male D, Pryce G, Linke A, Rahman J ( 1992 ) . Lymphocyte migration into the CNS modelled in vitro . Journal of Neuroimmunology vol. 40 , ( 2-3 ) 167 - 171 .
Pryce G, Male DK, Sarkar C ( 1991 ) . Control of lymphocyte migration into brain: Selective interactions of lymphocyte subpopulations with brain endothelium . Immunology vol. 72 , ( 3 ) 393 - 398 .
Male D, Pryce G, Hughes C, Lantos P ( 1990 ) . Lymphocyte migration into brain modelled in vitro: Control by lymphocyte activation, cytokines, and antigen . Cellular Immunology vol. 127 , ( 1 ) 1 - 11 .
Male D, Pryce G, Rahman J ( 1990 ) . Comparison of the immunological properties of rat cerebral and aortic endothelium . Journal of Neuroimmunology vol. 30 , ( 2-3 ) 161 - 168 .
Pryce G, Male D, Sedgwick J ( 1989 ) . Antigen presentation in brain: Brain endothelial cells are poor stimulators of T-cell proliferation . Immunology vol. 66 , ( 2 ) 207 - 212 .
Male D, Pryce G ( 1989 ) . Induction of Ia molecules on brain endothelium is related to susceptibility to experimental allergic encephalomyelitis . Journal of Neuroimmunology vol. 21 , ( 1 ) 87 - 90 .
Male D, Pryce G ( 1988 ) . Kinetics of MHC gene expression and mRNA synthesis in brain endothelium . Immunology vol. 63 , ( 1 ) 37 - 42 .
Male D, Pryce G ( 1988 ) . Synergy between interferons and monokines in MHC induction on brain endothelium . Immunology Letters vol. 17 , ( 3 ) 267 - 271 .
Male DK, Pryce G, Hughes CCW ( 1987 ) . Antigen presentation in brain: MHC induction on brain endothelium and astrocytes compared . Immunology vol. 60 , ( 3 ) 453 - 459 .
Male DK, Pryce G, Butcher GW ( 1987 ) . SEROLOGICAL EVIDENCE FOR A DEFECT IN RT1.B (I‐A) EXPRESSION BY THE BDIX RAT STRAIN . International Journal of Immunogenetics vol. 14 , ( 6 ) 301 - 312 .
Banga JP, Mirakian R, Hammond L, Pryce G, Bidey S, Bottazzo F, Weetman AP, McGregor AM et al. ( 1986 ) . Characterization of monoclonal antibodies directed towards the microsomal/microvillar thyroid autoantigen recognized by Hashimoto autoantibodies . Clinical and Experimental Immunology vol. 64 , ( 3 ) 544 - 554 .
Male D, Pryce G ( 1986 ) . Agglutination Assay Using Protein A-Sensitized Erythrocytes for Detection of Immunoglobulin in Tissue Culture Supernatants . Methods in Enzymology vol. 121 , ( C ) 556 - 561 .
MALE DK, PRYCE G, COOKE A, HUTCHINGS P, MARSHALL S, ROITT IM ( 1986 ) . T and B Cell Connections in Experimentally Induced Autoimmunity . Annals of the New York Academy of Sciences vol. 475 , ( 1 ) 94 - 105 .
Male D, Lelchuk R, Curry S, Pryce G, Playfair JH ( 1985 ) . Serum IL-2 inhibitor in mice. II. Molecular characteristics . Immunology vol. 56 , ( 1 ) 119 - 125 .
Male DK, Champion BR, Pryce G, Matthews H, Shepherd P ( 1985 ) . Antigenic determinants of human thyroglobulin differentiated using antigen fragments . Immunology vol. 54 , ( 3 ) 419 - 427 .
Male D, Pryce G, Roitt I ( 1985 ) . Molecular analysis of induced idiotypes associated with autoanti-thyroglobulin . Molecular Immunology vol. 22 , ( 3 ) 255 - 263 .
Banga JP, Pryce G, Hammond L, Roitt IM ( 1985 ) . Structural features of the autoantigens involved in thyroid autoimmune disease: The thyroid microsomal/microvillar antigen . Molecular Immunology vol. 22 , ( 6 ) 629 - 642 .
BANGA JP, GUARNOTTA G, HARTE A, PRYCE G, CAMPBELL MA, QUARTEY‐PAPAFIO R, LYDYARD PM, ROITT IM ( 1984 ) . A Common Epitope Identified by a Monoclonal Antibody, MID 2, Present on All Leucocytes and Associated with a Group of High Molecular Weight Glycopeptides . Scandinavian Journal of Immunology vol. 19 , ( 1 ) 11 - 21 .
Banga JP, Pryce G, Hammond L, Roitt IM ( 1984 ) . Characterization of the human thyroid microsomal antigen involved in thyroid autoimmunity . Biochemical Society Transactions vol. 12 , ( 6 ) 1118 - 1119 .
Male D, Pryce G ( 1983 ) . A rapid assay for immunoglobulin in hybridoma supernatants . Immunological Investigations vol. 12 , ( 5 ) 465 - 471 .
Male D, Pryce G, Quartey‐Papafio R, Roitt I ( 1983 ) . The occurrence of defined idiotypes on autoantibodies to mouse thyroglobulin . European Journal of Immunology vol. 13 , ( 11 ) 942 - 947 .