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Research

Publications: Prof Edel O'Toole

Steele L, Schwartz J, Hansen CD, O'Toole EA ( 2021 ) . Prevalence and Characterization of Itch in Pachyonychia Congenita . JAMA Dermatology vol. 157 , ( 11 ) 1378 - 1380 .
Heywood WE, Bliss E, Bahelil F, Cyrus T, Crescente M, Jones T, Iqbal S, Paredes LG et al. ( 2021 ) . Proteomic signatures for perioperative oxygen delivery in skin after major elective surgery: mechanistic sub-study of a randomised controlled trial . British Journal of Anaesthesia vol. 127 , ( 4 ) 511 - 520 .
Lincoln V, Chao L, Woodley DT, Murrell D, Kim M, O'Toole EA, Ly A, Cogan J et al. ( 2021 ) . Over-expression of stromal periostin correlates with poor prognosis of cutaneous squamous cell carcinomas . Experimental Dermatology vol. 30 , ( 5 ) 698 - 704 .
Langton AK, Ayer J, Griffiths TW, Rashdan E, Naidoo K, Caley MP, Birch-Machin MA, O'Toole EA et al. ( 2021 ) . Distinctive clinical and histological characteristics of atrophic and hypertrophic facial photoageing . Journal of the European Academy of Dermatology and Venereology vol. 35 , ( 3 ) 762 - 768 .
Bodemer C, Steijlen P, Mazereeuw-Hautier J, O'Toole EA ( 2021 ) . Treatment of hereditary palmoplantar keratoderma: a review by analysis of the literature* . British Journal of Dermatology vol. 184 , ( 3 ) 393 - 400 .
Reynolds G, Vegh P, Fletcher J, Poyner EFM, Stephenson E, Goh I, Botting RA, Huang N et al. ( 2021 ) . Developmental cell programs are co-opted in inflammatory skin disease . Science vol. 371 , ( 6527 )
Steele L, Hong A, Balogh P, O'Toole EA, Harwood CA, Maruthappu T ( 2021 ) . Disseminated tinea incognita in a patient with ichthyosis vulgaris and eczema . Clinical and Experimental Dermatology vol. 46 , ( 1 ) 210 - 212 .
Tan XL, Thomas BR, Tan YJ, O’Toole EA ( 2021 ) . Effects of systemic therapies on pruritus in adults with atopic dermatitis: a systematic review and meta-analysis . Clinical and Experimental Dermatology
Steele L, Tawfik SS, O'Toole EA ( 2020 ) . The Proteolytic Network in Palmoplantar Keratoderma: SERPINA12 Joins the Family . Journal of Investigative Dermatology vol. 140 , ( 11 ) 2111 - 2113 .
Caley MP, Martins VL, Moore K, Lashari M, Nissinen L, Kähäri V-M, Alexander S, Jones E et al. ( 2020 ) . Loss of Laminin α3 induces cell invasion and macrophage infiltration in cutaneous squamous cell carcinoma . British Journal of Dermatology
Mateo-Casas M, Reyes S, O'Toole EA, De Trane S, Yildiz O, Allen-Philbey K, Mathews J, Baker D et al. ( 2020 ) . Severe skin reactions associated with cladribine in people with multiple sclerosis . Multiple Sclerosis and Related Disorders . vol. 43 ,
Enjalbert F, Dewan P, Caley MP, Jones EM, Morse MA, Kelsell DP, Enright AJ, O'Toole EA ( 2020 ) . 3D model of harlequin ichthyosis reveals inflammatory therapeutic targets . Journal of Clinical Investigation
Kazmi A, O'Toole E, Maruthappu T ( 2020 ) . Not just skin deep: a complicated DRESS . BRITISH JOURNAL OF DERMATOLOGY . vol. 182 , E129 - E130 .
Simpson JK, Martinez-Queipo M, Onoufriadis A, Tso S, Glass E, Liu L, Higashino T, Scott W et al. ( 2020 ) . Genotype–phenotype correlation in a large English cohort of patients with autosomal recessive ichthyosis . British Journal of Dermatology vol. 182 , ( 3 ) 729 - 737 .
Steele L, O'Toole EA ( 2020 ) . Pachyonychia congenita, a paradigm for rare skin disorders . British Journal of Dermatology vol. 182 , ( 3 ) 521 - 522 .
Funk T, Hansen CD, Paller A, O'Toole EA ( 2020 ) . Update on pachyonychia congenita research . British Journal of Dermatology vol. 182 , ( 3 ) 788 - 789 .
Thomas BR, O’Toole EA ( 2020 ) . Diagnosis and management of inherited palmoplantar keratodermas . Acta Dermato-Venereologica vol. 100 , ( 100-year theme Genodermatoses ) 168 - 176 .
Thomas BR, Javadzadeh S, Robinson E, Ahmed R, Begum R, Rahman S, Khanam H, Kelsell DP et al. ( 2019 ) . 163 Eczema: Relationships between the environment, severity and the risk of admission to hospital . Journal of Investigative Dermatology . vol. 139 ,
Jones EM, Marsh S, O’Shaughnessy RF, CAMERA E, Picardo M, Aumailley M, O’Toole E, Caley M ( 2019 ) . 274 Junctional Epidermolysis Bullosa: Bottom Up Control Of The Skin Barrier? . Journal of Investigative Dermatology . vol. 139 ,
Caley M, Marsh S, Martins VL, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al. ( 2019 ) . 298 Defective DNA Repair and Chromosomal Instability in RDEB . Journal of Investigative Dermatology . vol. 139 ,
Zamiri M, Wilson NJ, O'Toole EA, Smith FJD ( 2019 ) . Novel mutations in desmoglein 1: focal palmoplantar keratoderma in milder phenotypes . British Journal of Dermatology vol. 181 , ( 3 ) 618 - 620 .
Theocharopoulos I, O'Toole EA ( 2019 ) . Stopping pachyonychia congenita plantar pain with a statin? . British Journal of Dermatology vol. 181 , ( 3 ) 446 - 447 .
Javadzadeh S, O'Toole EA ( 2019 ) . Pyogenic granulomas as a side-effect of retinoid therapy, with ADAM17 as a potential key player: a case series . BRITISH JOURNAL OF DERMATOLOGY . vol. 181 , 83 - 83 .
Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM et al. ( 2019 ) . Loss-of-function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype . British Journal of Dermatology vol. 180 , ( 5 ) 1114 - 1122 .
Mazereeuw-Hautier J, Hernández-Martín A, O'Toole EA, Bygum A, Amaro C, Aldwin M, Audouze A, Bodemer C et al. ( 2019 ) . Management of congenital ichthyoses: European guidelines of care, part two . British Journal of Dermatology vol. 180 , ( 3 ) 484 - 495 .
Mazereeuw-Hautier J, Vahlquist A, Traupe H, Bygum A, Amaro C, Aldwin M, Audouze A, Bodemer C et al. ( 2019 ) . Management of congenital ichthyoses: European guidelines of care, part one . British Journal of Dermatology vol. 180 , ( 2 ) 272 - 281 .
Smith PP, Dhillon-Smith RK, O'Toole E, Cooper N, Coomarasamy A, Clark TJ ( 2019 ) . Outcomes in prevention and management of miscarriage trials: a systematic review . BJOG vol. 126 , ( 2 ) 176 - 189 .
Bladen JC, Wang J, Sangaralingam A, Moosajee M, Fitchett C, Chelala C, Beaconsfield M, O'Toole EA et al. ( 2018 ) . MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma . Scientific Reports vol. 8 , ( 1 )
David J, O'Toole E, O'Reilly K, Thuery G, Assmann N, Finlay D, Harkin A ( 2018 ) . Inhibitors of the NMDA-Nitric Oxide Signaling Pathway Protect Against Neuronal Atrophy and Synapse Loss Provoked by l-alpha Aminoadipic Acid-treated Astrocytes . Neuroscience vol. 392 , 38 - 56 .
Vodo D, O'Toole EA, Malchin N, Lahav A, Adir N, Sarig O, Green KJ, Smith FJD et al. ( 2018 ) . Striate palmoplantar keratoderma resulting from a missense mutation in DSG1 . British Journal of Dermatology vol. 179 , ( 3 ) 755 - 757 .
Alexander SC, Marsh S, Caley M, O'Toole EA ( 2018 ) . Understanding Angiogenesis in Squamous Cell Carcinoma with Loss of Type VII Collagen . JOURNAL OF PATHOLOGY . vol. 246 , S44 - S44 .
Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ et al. ( 2018 ) . Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker . EUROPEAN HEART JOURNAL . vol. 39 , 1206 - 1206 .
Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ et al. ( 2018 ) . P5709Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker . European Heart Journal vol. 39 , ( suppl_1 )
Wray EV, Wilson NJ, O'Toole E, Smith F, Zamiri M ( 2018 ) . Novel mutations in desmoglein 1: focal palmoplantar keratoderma in milder phenotypes . BRITISH JOURNAL OF DERMATOLOGY . vol. 179 , 82 - 83 .
Simpson J, Martinez-Queipo M, Onoufriadis A, Tso S, Glass E, Liu L, Higashino T, Scott W et al. ( 2018 ) . Phenotypic spectrum of 146 cases of autosomal recessive congenital ichthyosis in England . BRITISH JOURNAL OF DERMATOLOGY . vol. 179 , 80 - 81 .
Krupiczojc MA, O'Toole EA ( 2018 ) . Plantar pain in pachyonychia congenita . British Journal of Dermatology vol. 179 , ( 1 ) 11 - 12 .
KELSELL DP, O'TOOLE E, PIGORS M, SCOTT CA, Tabarra N, VAN HEEL DA ( 2018 ) . Exome sequencing and rare variant analysis reveals multiple filaggrin mutations in Bangladeshi atopic eczema families and novel risk genes . Journal of Investigative Dermatology
Enjalbert F, Dewan P, Caley MP, Fell B, Morse M, Kelsell D, Enright A, O'Toole EA ( 2018 ) . 661 Understanding the role of ABCA12 in the pathogenesis of harlequin ichthyosis . Journal of Investigative Dermatology . vol. 138 ,
Jones E, Marsh S, O'Shaughnessy R, Aumailley M, O'Toole EA, Caley MP ( 2018 ) . 680 A role for the basement membrane in skin lipid trafficking . Journal of Investigative Dermatology . vol. 138 ,
Marsh S, Caley MP, Martins V, Chen M, McGrath J, Barnes M, O'Toole EA ( 2018 ) . 812 Type VII collagen and Nesprin 2, LINCing the basement membrane to altered cell cycle and increased DNA damage . Journal of Investigative Dermatology . vol. 138 ,
Bladen JC, Moosajee M, Tracey-White D, Beaconsfield M, O’Toole EA, Philpott MP ( 2018 ) . Analysis of hedgehog signaling in periocular sebaceous carcinoma . Graefe's Archive for Clinical and Experimental Ophthalmology vol. 256 , ( 4 ) 853 - 860 .
McDonald BS, Pigors M, Kelsell DP, O'Toole EA, Burkitt-Wright E, Kerr B, Batta K ( 2018 ) . Noonan syndrome with multiple lentigines and associated craniosynostosis . Clinical and Experimental Dermatology vol. 43 , ( 3 ) 357 - 359 .
Maruthappu T, McGinty LA, Blaydon DC, Fell B, Määttä A, Duit R, Hawkins T, Braun KM et al. ( 2018 ) . Recessive Mutation in FAM83G Associated with Palmoplantar Keratoderma and Exuberant Scalp Hair . Journal of Investigative Dermatology vol. 138 , ( 4 ) 984 - 987 .
Thomas LJ, Freeman A, O'Toole EA, McGrath JA, Perrett CM ( 2018 ) . Inherited palmoplantar keratodermas: the heart of the matter . Clinical and Experimental Dermatology vol. 43 , ( 2 ) 228 - 230 .
Smith CJ, Caley M, Parkinson EK, O'Toole EA, Pratten J, Yang J ( 2018 ) . INVESTIGATING THE DIFFERENCES IN THE WOUND HEALING RESPONSES OF SKIN AND GINGIVAL KERATINOCYTES . WOUND REPAIR AND REGENERATION . vol. 26 , A30 - A31 .
Ip SCI, Cottle DL, Jones LK, Weir JM, Kelsell DP, O'Toole EA, Meikle PJ, Smyth IM ( 2017 ) . A profile of lipid dysregulation in harlequin ichthyosis . Br J Dermatol vol. 177 , ( 5 ) e217 - e219 .
Enjalbert F, Dewan P, Caley M, Fell B, Morse M, Kelsell DP, Enright A, O'Toole EA ( 2017 ) . Understanding the role of ABCA12 in the Pathogenesis of Harlequin Ichthyosis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . Conference: ESDR 2017 vol. 137 , S208 - S208 .
Badowski C, Sim AYL, Verma C, Szeverényi I, Natesavelalar C, Terron-Kwiatkowski A, Harper J, O'Toole EA et al. ( 2017 ) . Modeling the Structure of Keratin 1 and 10 Terminal Domains and their Misassembly in Keratoderma . Journal of Investigative Dermatology vol. 137 , ( 9 ) 1914 - 1923 .
Kanapathy M, Hachach-Haram N, Bystrzonowski N, Connelly JT, O'Toole EA, Becker DL, Mosahebi A, Richards T ( 2017 ) . Epidermal grafting for wound healing: a review on the harvesting systems, the ultrastructure of the graft and the mechanism of wound healing . International Wound Journal vol. 14 , ( 1 ) 16 - 23 .
Kelsell DP, Rajpopat S, Thomas A, O'Toole EA ( 2016 ) . Harlequin Ichthyosis: genetic, functional and clinical investigations . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 50 - 50 .
O'Toole EA, Ruban EL, Balogun M, Martins VL, Caley MP, Falasca M ( 2016 ) . Phospholipase C beta4 is a therapeutic target in cutaneous squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 56 - 57 .
McGeoghan F, Menon M, Dewan P, Caley M, Donaldson M, O’Toole EA ( 2016 ) . 132 Identification of novel pathways linked to the pathogenesis of Recessive X-Linked Ichthyosis . Journal of Investigative Dermatology . vol. 136 ,
Enjalbert F, Dewan P, Caley M, Fell B, Donaldson M, Kelsell DP, O’Toole EA ( 2016 ) . 133 Understanding the role of ABCA12 in the pathogenesis of Harlequin Ichthyosis . Journal of Investigative Dermatology . vol. 136 ,
Maruthappu T, McGinty L, Blaydon D, Duit R, Maatta A, O’Toole E, Kelsell DP ( 2016 ) . 180 Mutations in FAM83G/PAWS1 cause autosomal recessive palmoplantar keratoderma with leukonychia and abundant curly hair . Journal of Investigative Dermatology . vol. 136 ,
Posafalvi A, Maruthappu T, Castelletti S, Syrris P, O’Toole E, McKenna WJ, Kelsell DP ( 2016 ) . 183 Clinical and genetic studies reveal cutaneous phenotypes linked to desmoplakin haploinsufficiency in arrhythmogenic cardiomyopathy . vol. 136 , is. 9 ,
Caley M, Martins V, Moore K, Lashari M, Kähäri V, Nissinen L, Donaldson M, Marshall J et al. ( 2016 ) . 472 Loss of Laminin α3 drives SCC invasion via ROCK signalling . Journal of Investigative Dermatology . vol. 136 ,
Ahmed A, McGinty L, Blaydon D, Kelsell DP, O'Toole EA, De Silva B ( 2016 ) . Mild arthrogryposis, renal dysfunction and cholestasis syndrome caused by a novel splice-site mutation in VPS33B . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 81 - 82 .
McDonald B, Amieva M, Kelsell DP, O'Toole EA, Burkett-Wright E, Kerr B, Batta K ( 2016 ) . Noonan syndrome with multiple lentigines identified by next-generation sequencing . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 163 - 163 .
Ziaj S, Pigors M, Scott C, Lewis F, Ali I, Roberts N, Kelsell DP, O'Toole EA ( 2016 ) . Novel mutations in SLURP1 causing Mal de Meleda palmoplantar keratoderma with varying phenotypes . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 81 - 81 .
Muttardi K, Nitoiu D, Kelsell DP, O'Toole EA, Batta K ( 2016 ) . Acral peeling skin syndrome associated with a novel CSTA gene mutation . Clinical and Experimental Dermatology vol. 41 , ( 4 ) 394 - 398 .
McGeoghan FT, O’Toole E, Caley M, Menon M, Dewan P, Donaldson M ( 2016 ) . 375 Modelling and understanding pathomechanisms of X-linked recessive ichthyosis in vitro . Journal of Investigative Dermatology . vol. 136 ,
Pigors M, Common JE, Wong C, Malik S, Scott CA, Foo J, Liu J, Margolis D et al. ( 2016 ) . 380 Exome sequencing and rare variant analysis reveals multiple filaggrin mutations in Bangladeshi atopic eczema families and novel risk genes . Journal of Investigative Dermatology . vol. 136 ,
Chao L, Gor V, Murrell DF, Kim M, O’Toole E, Ly A, Woodley D, Wysong A et al. ( 2016 ) . 421 Over-expression of periostin is associated with clinical outcomes and poor prognosis in cutaneous squamous cell carcinoma . Journal of Investigative Dermatology . vol. 136 ,
Badowski C, Sim AYL, Verma C, Szeverenyi I, Dang TT, Ng Y, Natesavelalar C, Benny P et al. ( 2016 ) . A new model for the structure of the head domains of keratins K1 and K10 and its implications for striate palmoplantar keratoderma . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E45 - E45 .
Kenny F, Kao A, Barber A, O'Toole E, Connelly J ( 2016 ) . Epidermal growth factor signalling mediates keratinocyte mechanoregulation . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E44 - E44 .
Pigors M, Common JEA, Wong C, Scott CA, Foo JN, Liu J, O'Toole E, Simpson MA et al. ( 2016 ) . Exome sequencing reveals multiple filaggrin mutations in Bangladeshi families with atopic eczema . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E64 - E65 .
Caley M, Martins V, Moore K, Lashari M, Donaldson M, Marshall JF, O'Toole EA ( 2016 ) . ROCK and Rac1 signalling in squamous cell carcinoma with loss of laminin 332 . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E51 - E51 .
Wee JS, Smith FJD, Wilson NJ, O'Toole EA ( 2016 ) . Focal PPK secondary to a novel KRT6C mutation (Pachyonychia congenita-K6c) . Journal of the European Academy of Dermatology and Venereology vol. 30 , ( 8 ) 1415 - 1416 .
Krupiczojc MA, O'Toole EA ( 2016 ) . Management of cutaneous squamous cell carcinoma in patients with epidermolysis bullosa . British Journal of Dermatology vol. 174 , ( 1 )
Hill DS, Robinson NDP, Caley MP, Chen M, O'Toole EA, Armstrong JL, Przyborski S, Lovat PE ( 2015 ) . A novel fully humanized 3D skin equivalent to model early melanoma invasion . Molecular Cancer Therapeutics vol. 14 , ( 11 ) 2665 - 2673 .
Wilson NJ, Cole C, Milstone LM, Kiszewski AE, Hansen CD, O'Toole EA, Schwartz ME, McLean WHI et al. ( 2015 ) . Expanding the Phenotypic Spectrum of Olmsted Syndrome . Journal of Investigative Dermatology vol. 135 , ( 11 ) 2879 - 2883 .
Thomson J, O'Toole EA ( 2015 ) . The future of U.K. dermatology translational research through the Oracle of Delphi . British Journal of Dermatology vol. 173 , ( 5 ) 1122 - 1123 .
Kopecki Z, Yang GN, Jackson JE, Melville EL, Calley MP, Murrell DF, Darby IA, O'Toole EA et al. ( 2015 ) . Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression . Oncotarget vol. 6 , ( 34 ) 36426 - 36440 .
Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M et al. ( 2015 ) . Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC . J Natl Cancer Inst vol. 108 , ( 1 )
Marsh S, Martins V, Caley M, Barnes M, Donaldson MJ, O'toole E ( 2015 ) . Loss of keratinocyte type VII collagen induces pro-carcinogenic transcriptomic pathways . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 135 , S44 - S44 .
McGeoghan FT, Derwin P, Caley M, Donaldson MJ, O'toole E ( 2015 ) . Modelling X-linked recessive ichthyosis in vitro . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 135 , S62 - S62 .
Martins V, Caley M, Moore K, Szentpetery Z, Marsh S, Murrell DF, Kaehaeri V, McGrath J et al. ( 2015 ) . Skin type VII collagen acts as a tumour suppressor by regulating TGF beta and angiogenesis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 135 , S28 - S28 .
Caley M, Martins V, Marsh S, Moore K, Lashari M, Donaldson MJ, Marshall J, O'toole E ( 2015 ) . Squamous Cell Carcinoma progression and Laminin 332 . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 135 , S23 - S23 .
Chinthapalli S, Buckley D, Lin Z, Nitoiu D, Scott C, Smith F, Yang Y, Kelsell D et al. ( 2015 ) . A novel peeling skin syndrome . BRITISH JOURNAL OF DERMATOLOGY . vol. 173 , 78 - 78 .
Knöbel M, O'Toole EA, Smith FJD ( 2015 ) . Keratins and skin disease . Cell Tissue Res vol. 360 , ( 3 ) 583 - 589 .
Kenny F, Kao A, Barber A, O'Toole E, Connelly JT ( 2015 ) . Epidermal growth factor signalling mediates mechanoregulation of keratinocyte proliferation . BRITISH JOURNAL OF DERMATOLOGY . vol. 172 , E33 - E33 .
McGeoghan F, Dewan P, Caley M, Donaldson M, O'Toole E ( 2015 ) . Generation of an in vitro three-dimensional model of X-linked recessive ichthyosis . BRITISH JOURNAL OF DERMATOLOGY . vol. 172 , E40 - E40 .
Lin Z, Zhao J, Nitoiu D, Scott CA, Plagnol V, Smith FJD, Wilson NJ, Cole C et al. ( 2015 ) . Loss-of-function mutations in CAST cause peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads . American Journal of Human Genetics vol. 96 , ( 3 ) 440 - 447 .
O'Toole EA, Kaspar RL, Sprecher E, Schwartz ME, Rittié L ( 2014 ) . Pachyonychia congenita cornered: report on the 11th Annual International Pachyonychia Congenita Consortium Meeting . Br J Dermatol vol. 171 , ( 5 ) 974 - 977 .
Brooke MA, O'Toole EA, Kelsell DP ( 2014 ) . Exoming into rare skin disease: EGFR deficiency . J Invest Dermatol vol. 134 , ( 10 ) 2486 - 2488 .
Caley M, Martins V, Moore K, Marshall J, O'toole E ( 2014 ) . Diverse roles for laminin 332 subunits in squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S19 - S19 .
Lin Z, Nitoiu D, Scott C, Zhao J, Plagnol V, O'toole E, Kelsell D, Yang Y ( 2014 ) . Peeling skin, leukonychia, acral punctate keratoses, cheilitis and knuckle pads with milia caused by loss-of-function mutations in calpastatin . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S53 - S53 .
Ruban EL, Balogun MA, Martins V, Caley M, Raimondi C, O'toole E, Falasca M ( 2014 ) . Phospholipase C beta4 regulates invasion and proliferation in cutaneous SCC in vivo . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S22 - S22 .
Marsh S, Martins V, Caley M, Barnes M, Donaldson M, O'toole E ( 2014 ) . RNA-Seqing the skin basement membrane . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S25 - S25 .
Ahmed H, O'Toole EA ( 2014 ) . Recent advances in the genetics and management of harlequin ichthyosis . Pediatr Dermatol vol. 31 , ( 5 ) 539 - 546 .
Cichoń MA, Szentpetery Z, Caley MP, Papadakis ES, Mackenzie IC, Brennan CH, O'Toole EA ( 2014 ) . The receptor tyrosine kinase Axl regulates cell-cell adhesion and stemness in cutaneous squamous cell carcinoma . Oncogene vol. 33 , ( 32 ) 4185 - 4192 .
Wilson NJ, O'Toole EA, Milstone LM, Hansen CD, Shepherd AA, Al-Asadi E, Schwartz ME, McLean WHI et al. ( 2014 ) . The molecular genetic analysis of the expanding pachyonychia congenita case collection . BRITISH JOURNAL OF DERMATOLOGY vol. 171 , ( 2 ) 343 - 355 .
Brooke MA, Etheridge SL, Kaplan N, Simpson C, O'Toole EA, Ishida-Yamamoto A, Marches O, Getsios S et al. ( 2014 ) . iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function . Hum Mol Genet vol. 23 , ( 15 ) 4064 - 4076 .
Sommerlad M, Scott C, Harwood C, Kelsell D, O'Toole E ( 2014 ) . Ichthyosis with striate keratoderma caused by a compound heterozygous mutation in ichthyin/NIPAL4 . BRITISH JOURNAL OF DERMATOLOGY . vol. 171 , 118 - 119 .
Muttardi K, Nitoiu D, Kelsell DP, O'Toole EA, Batta K ( 2014 ) . Peeling the surface of cystatin A defects . BRITISH JOURNAL OF DERMATOLOGY . vol. 171 , 117 - 118 .
Ooi J, Chinthapalli S, O'Toole E, Alazawi W ( 2014 ) . PWE-142 Is Liver Disease Overlooked In Patients With Psoriasis? . Gut vol. 63 Suppl 1 ,
O'Toole EA ( 2014 ) . Type VII collagen and squamous cell carcinoma . Br J Dermatol vol. 170 , ( 6 )
Kopecki Z, Yang G, Jackson J, Melville E, Martin V, Caley M, Proby C, Pouniotis D et al. ( 2014 ) . Cytoskeletal protein Flii is elevated in human cSCCs and overexpression of Flii in mice leads to higher incidence and severity of tumour formation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S28 - S28 .
Brown L, Waseem A, Cruz IN, Szary J, Gunic E, Mannan T, Unadkat M, Yang M et al. ( 2014 ) . Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation . Oncogene vol. 33 , ( 18 ) 2363 - 2374 .
Bladen J, Thaung C, Beaconsfield M, O'Toole E, Philpott M ( 2014 ) . Analysis of the Hedgehog signalling pathway in periocular sebaceous gland carcinoma . INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . vol. 55 ,
Caley M, Martins V, Moore K, Marshall J, O'Toole E ( 2014 ) . Diverse roles for laminin-332 subunits in squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 170 , E26 - E26 .
Marsh S, Martins V, Caley M, Barnes M, Donaldson M, O'Toole E ( 2014 ) . Global transcriptomic changes in primary keratinocytes with loss of basement membrane genes . BRITISH JOURNAL OF DERMATOLOGY . vol. 170 , E37 - E38 .
Kopecki Z, Yang G, Jackson J, Melville E, Martin V, Matthew C, Proby C, Pouniotis D et al. ( 2014 ) . TREATMENT OF SCC WITH FLIGHTLESS NEUTRALIZING ANTIBODY BLOCKS CELL INVASION AND REDUCES TUMOR GROWTH IN MICE . WOUND REPAIR AND REGENERATION vol. 22 , ( 2 ) A49 - A49 .
Kulkarni M, O'Loughlin A, Vazquez R, Mashayekhi K, Rooney P, Greiser U, O'Toole E, O'Brien T et al. ( 2014 ) . Use of a fibrin-based system for enhancing angiogenesis and modulating inflammation in the treatment of hyperglycemic wounds . Biomaterials vol. 35 , ( 6 ) 2001 - 2010 .
Jones M, Dry IR, Frampton D, Singh M, Kanda RK, Yee MB, Kellam P, Hollinshead M et al. ( 2014 ) . RNA-seq analysis of host and viral gene expression highlights interaction between varicella zoster virus and keratinocyte differentiation . PLoS Pathog vol. 10 , ( 1 )
Blaydon DC, Lind LK, Plagnol V, Linton KJ, Smith FJD, Wilson NJ, McLean WHI, Munro CS et al. ( 2013 ) . Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma . Am J Hum Genet vol. 93 , ( 2 ) 330 - 335 .
Blaydon DC, Lind L, Plagnol V, Linton KJ, South AP, Leigh IM, O'Toole EA, Lundstrom A et al. ( 2013 ) . Aquaporin 5 (AQP5), a water channel protein, is mutated in autosomal dominant diffuse non-epidermolytic palmoplantar keratoderma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S139 - S139 .
Caley MP, Martins V, Moore K, Marshall JF, O'Toole EA ( 2013 ) . Diverse roles for laminin 332 subunits in squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S64 - S64 .
Martins VL, Caley MP, Moore K, Szentpetery Z, Murrell DF, Kim MH, McGrath JA, Cerio R et al. ( 2013 ) . Loss of type VII collagen in cutaneous SCC increases angiogenesis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S158 - S158 .
Ruban EL, Martins VL, Caley M, Raimondi C, Falasca M, O'Toole EA ( 2013 ) . Phospholipase C-beta 4 regulates proliferation and invasion in cutaneous SCC . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S73 - S73 .
Marsh ST, Martins VL, Donaldson M, Braun K, O'Toole EA ( 2013 ) . Regulation of normal epidermal homeostasis by the basement membrane . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S157 - S157 .
Szentpetery Z, Lovat PE, Bergamaschi D, O'Toole EA ( 2013 ) . The receptor tyrosine kinase, Axl, as a therapeutic target in malignant melanoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S240 - S240 .
Marsh ST, Caley MP, Kwan A, O'Toole EA, Donaldson M ( 2013 ) . Transcriptome profiling identifies novel functions of acitretin in human epidermis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S186 - S186 .
Martins VL, Caley M, O'Toole EA ( 2013 ) . Matrix metalloproteinases and epidermal wound repair . Cell Tissue Res vol. 351 , ( 2 ) 255 - 268 .
Scott CA, Plagnol V, Nitoiu D, Bland PJ, Blaydon DC, Chronnell CM, Poon DS, Bourn D et al. ( 2013 ) . Targeted sequence capture and high-throughput sequencing in the molecular diagnosis of ichthyosis and other skin diseases . J Invest Dermatol vol. 133 , ( 2 ) 573 - 576 .
Scott CA, Plagnol V, Nitoiu D, Bland PJ, Blaydon DC, Chronnell CM, Poon DS, Bourn D et al. ( 2013 ) . Targeted sequence capture and high-throughput sequencing in the molecular diagnosis of ichthyosis and other skin diseases . Journal of Investigative Dermatology vol. 133 , ( 2 ) 573 - 576 .
Brown LE, Gunic E, Unadkat M, Mannan T, Tsang S, Ahmed W, Valderrama F, O'Toole EA et al. ( 2012 ) . Desmoglein 3 regulates cancer cell migration through Protein Kinase C dependent-ezrin activation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S37 - S37 .
Kulkarni M, O'Loughlin A, Vazquez-Martinez R, Mashayekhi K, Greiser U, O'Toole E, O'Brien T, Malagon M et al. ( 2012 ) . Fibrin mediated proangiogenic and secretory control gene therapy for compromised wound healing . JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE vol. 6 , 291 - 291 .
Singh M, Caley M, Jones M, Breuer J, O'Toole E ( 2012 ) . Keratin 15 and VZV replication in skin . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S112 - S112 .
Martins V, Caley M, Moore K, Murrell DF, McGrath JA, Chen M, Marshall JF, O'Toole EA ( 2012 ) . Loss of keratinocyte type VII collagen in SCC increases TGF-beta signalling and angiogenesis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S45 - S45 .
Szentpetery Z, Cichon M, Caley M, O'Toole E ( 2012 ) . The receptor tyrosine kinase Axl regulates intercellular adhesion, epithelial-mesenchymal transition and stemness in cutaneous squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S45 - S45 .
Scott CA, Tattersall D, O'Toole EA, Kelsell DP ( 2012 ) . Connexins in epidermal homeostasis and skin disease . Biochimica et Biophysica Acta - Biomembranes vol. 1818 , ( 8 ) 1952 - 1961 .
Wan H, Brown L, Gunic E, Mannan T, Tsang S, Valderrama F, O'Toole E ( 2012 ) . Desmoglein 3 Regulates Cancer Cell Migration Through PKC Dependent-ezrin Activation . EUROPEAN JOURNAL OF CANCER . vol. 48 , S45 - S46 .
Tsang SM, Brown L, Lin K, Liu L, Piper K, O'Toole EA, Grose R, Hart IR et al. ( 2012 ) . Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris . J Pathol vol. 227 , ( 1 ) 81 - 93 .
Marsh ST, Martins V, Braun K, Donaldson M, O'Toole EA ( 2012 ) . The role of the basement membrane in stem cell maintenance and epidermal homeostasis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S34 - S34 .
Martins V, Caley M, Moore K, Chen M, Marshall J, O'Toole E ( 2012 ) . Loss of type VII collagen in squamous cell carcinoma increases angiogenesis in vitro and in vivo . BRITISH JOURNAL OF DERMATOLOGY . vol. 166 , e25 - e26 .
Tull T, Chu A, O'Toole E, Teixeira F, Schmid K, Punjabi S ( 2012 ) . Macrocephaly: Capillary malformation with the neuroradiologic features of Sturge-Weber syndrome: A syndrome overlap? . JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY . vol. 66 , AB95 - AB95 .
Scott C, Bland P, Plagnol V, Nitoiu D, Poon D, O'Toole E, Kelsell D ( 2012 ) . Next-generation sequencing in genetic diagnosis of skin disease . BRITISH JOURNAL OF DERMATOLOGY . vol. 166 , e34 - e34 .
Ruban EL, Martins VL, Falasca M, O'Toole EA ( 2012 ) . Phospholipase C signalling in cutaneous squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 166 , e23 - e24 .
Marsh S, Martins V, Braun K, Donaldson M, O'Toole E ( 2012 ) . The role of the basement membrane in normal epidermal homeostasis . BRITISH JOURNAL OF DERMATOLOGY . vol. 166 , e32 - e32 .
Kulkarni M, O'loughlin A, Vazquez R, Mashayekhi K, Greiser U, O'toole EA, O'brien T, Malagon MM et al. ( 2011 ) . Spatiotemporally controlled proangiogenic and secretory control therapy for compromised wound healing . 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials .
Blaydon DC, Biancheri P, Di W-L, Plagnol V, Cabral RM, Brooke MA, van Heel DA, Ruschendorf F et al. ( 2011 ) . Inflammatory skin and bowel disease linked to ADAM17 deletion . N Engl J Med vol. 365 , ( 16 ) 1502 - 1508 .
Ruban E, Martins V, Falasca M, O'Toole E ( 2011 ) . Phospholipase C signalling in cutaneous squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 131 , S32 - S32 .
Marsh S, Martins V, O'Toole E ( 2011 ) . The role of the basement membrane in normal epidermal homeostasis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 131 , S33 - S33 .
Dewan P, Robinson J, O'Toole E, Paige DG, Goldsmith P ( 2011 ) . Need for transition in dermatology: a study from a London teaching hospital . BRITISH JOURNAL OF DERMATOLOGY . vol. 165 , 20 - 20 .
Dewan P, Terron-Kwiatkowski A, Rajpopat S, Dopping-Hepenstal PJ, McGrath JA, Baty D, O'Toole EA ( 2011 ) . Recessive epidermolytic palmoplantar keratoderma caused by a keratin 1 mutation . BRITISH JOURNAL OF DERMATOLOGY . vol. 165 , 120 - 120 .
Rajpopat S, Moss C, Mellerio J, Vahlquist A, Gånemo A, Hellstrom-Pigg M, Ilchyshyn A, Burrows N et al. ( 2011 ) . Harlequin ichthyosis: a review of clinical and molecular findings in 45 cases . Arch Dermatol vol. 147 , ( 6 ) 681 - 686 .
O'Toole EA, Kelsell DP ( 2011 ) . Collodion Baby . Harper's Textbook of Pediatric Dermatology: Third Edition , vol. 1 ,
O'Toole EA, Kelsell DP ( 2011 ) . Harlequin Ichthyosis . Harper's Textbook of Pediatric Dermatology: Third Edition , vol. 1 ,
Martinez-Levasseur LM, Gendron D, Knell RJ, O'Toole EA, Singh M, Acevedo-Whitehouse K ( 2011 ) . Acute sun damage and photoprotective responses in whales . Proc Biol Sci vol. 278 , ( 1711 ) 1581 - 1586 .
Cichon MA, Mackenzie IC, O'Toole EA ( 2011 ) . Axl plays a role in cell adhesion and 'stemness' in cutaneous SCC . BRITISH JOURNAL OF DERMATOLOGY . vol. 164 , 908 - 909 .
Martins VL, Moore K, Chen M, Marshall J, O'Toole EA ( 2011 ) . Loss of type VII collagen in SCC leads to increased invasion and TGF-beta signalling in vivo . BRITISH JOURNAL OF DERMATOLOGY . vol. 164 , 910 - 910 .
Ruban EL, Martins VL, Falasca M, O'Toole EA ( 2011 ) . Phospholipase C signalling in cutaneous squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 164 , 935 - 935 .
Dewan P, Terron-Kwiatkowski A, Rajpopat S, Baty D, O'Toole EA ( 2011 ) . Recessive epidermolytic palmoplantar keratoderma caused by a keratin 1 mutation . BRITISH JOURNAL OF DERMATOLOGY . vol. 164 , 932 - 932 .
Wong S, Rizvi H, Cerio R, O'Toole EA ( 2011 ) . An unusual case of vulval papulonecrotic tuberculid . Clin Exp Dermatol vol. 36 , ( 3 ) 277 - 280 .
Martins V, Moore K, Chen M, Marshall J, O'Toole EA ( 2011 ) . Loss of type VII collagen in squamous cell carcinoma leads to increased invasion and TGF-beta signalling in vivo . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 131 , S33 - S33 .
Talsania N, Jolliffe V, O'Toole EA, Cerio R ( 2011 ) . Platelike osteoma cutis . J Am Acad Dermatol vol. 64 , ( 3 ) 613 - 615 .
Martinez-Levasseur LM, Gendron D, Knell RJ, O'Toole EA, Singh M, Acevedo-Whitehouse K ( 2011 ) . Acute sun damage and photoprotective responses in whales . Proceedings of the Royal Society B vol. 278 , ( 1711 ) 1581 - 1586 .
Scott CA, Tattersall D, O'Toole EA, Kelsell DP ( 2011 ) . Connexins in epidermal homeostasis and skin disease . Biochimica et Biophysica Acta - Biomembranes
Scott CA, O'Toole EA, Mohungoo MJ, Messenger A, Kelsell DP ( 2011 ) . Novel and recurrent connexin 30.3 and connexin 31 mutations associated with erythrokeratoderma variabilis . Clin Exp Dermatol vol. 36 , ( 1 ) 88 - 90 .
Martins V, Chen M, Purdie K, O'Toole E ( 2010 ) . Loss of type VII collagen in cutaneous SCC increases cell invasion through TGF-beta signalling . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 130 , S19 - S19 .
Ruban E, Martins V, Falasca M, O'Toole E ( 2010 ) . Phospholipase C signalling in cutaneous squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 130 , S31 - S31 .
Cichon M, Mackenzie I, O'Toole E ( 2010 ) . The role of the receptor tyrosine kinase Axl in intercellular adhesion and signalling in cutaneous squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 130 , S15 - S15 .
O'Toole EA ( 2010 ) . Molecular Biology . Rook's Textbook of Dermatology: Eighth Edition , vol. 1 ,
O'Toole EA, Mellerio JE ( 2010 ) . Wound Healing . Rook's Textbook of Dermatology: Eighth Edition , vol. 1 ,
Martins VL, Chen M, Purdie KJ, O'Toole EA ( 2010 ) . Inhibition of the transforming growth factor-beta pathway decreases cell movement in squamous cell carcinoma cells with loss of type VII collagen . BRITISH JOURNAL OF DERMATOLOGY . vol. 162 , 947 - 947 .
Rajpopat S, Poon DS, O'Toole EA, Kelsell DP ( 2010 ) . Loss of ABCA12 leads to dysregulated expression of the nuclear hormone receptor pathway molecules RXR-alpha, PPAR-delta and the lipid transporter ABCA1 . BRITISH JOURNAL OF DERMATOLOGY . vol. 162 , 939 - 939 .
Cichon MA, Mackenzie IC, O'Toole EA ( 2010 ) . The role of the receptor tyrosine kinase Axl in cell-cell adhesion and signaling in cancer . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 130 , S34 - S34 .
Cichon MA, Mackenzie IC, O'Toole EA ( 2010 ) . The role of the receptor tyrosine kinase Axl in intercellular adhesion and signalling in cancer . BRITISH JOURNAL OF DERMATOLOGY . vol. 162 , 922 - 922 .
Singh M, Breuer J, Heseltine R, Cerio R, Millar J, Philpott MP, O'Toole EA ( 2010 ) . Varicella-zoster replication and its association with keratin 15 expression and Wnt signalling . BRITISH JOURNAL OF DERMATOLOGY . vol. 162 , 914 - 915 .
Majmudar V, Herath D, O'Toole EA, Harrison A ( 2010 ) . Bullous pemphigoid of childhood: a rare disease with diagnostic and management challenges . CLIN EXP DERMATOL vol. 35 , ( 2 ) 213 - 214 .
Wilson NJ, Messenger AG, Leachman SA, O'Toole EA, Lane EB, McLean WHI, Smith FJD ( 2010 ) . Keratin K6c Mutations Cause Focal Palmoplantar Keratoderma . J INVEST DERMATOL vol. 130 , ( 2 ) 425 - 429 .
Papadakis ES, Cichon M, Vyas JJ, Patel N, Ghali L, Cerio R, Storey A, O'Toole EA ( 2010 ) . Axl Promotes Cutaneous Squamous Cell Carcinoma Survival Through Negative Regulation of Pro-Apoptotic Bcl-2 Family Members . Journal of Investigative Dermatology vol. 131 , 509 - 517 .
South AP, O'Toole EA ( 2010 ) . Understanding the Pathogenesis of Recessive Dystrophic Epidermolysis Bullosa Squamous Cell Carcinoma . DERMATOL CLIN vol. 28 , ( 1 ) 171 - + .
Talsania N, O'Toole EA ( 2009 ) . Severe hypersensitivity reaction to minocycline in association with lymphomatoid papulosis . Clin Exp Dermatol vol. 34 , ( 7 ) e397 - e398 .
Papadakis ES, Storey A, O'Toole EA ( 2009 ) . A role for the receptor tyrosine kinase Axl in regulating NF-kappa B activity in cutaneous squamous cell carcinomas . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 129 , S72 - S72 .
Rajpopat S, O'Toole EA, Kelsell DP ( 2009 ) . Harlequin ichthyosis: prenatal diagnosis and a review of the clinical outcome of survivors . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 129 , S52 - S52 .
Martins VL, Chen M, Purdie K, McGrath JA, O Toole EA ( 2009 ) . Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of type VII collagen . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 129 , S82 - S82 .
Cichon MA, Papadakis ES, Mackenzie IC, O'Toole EA ( 2009 ) . The role of the receptor tyrosine kinase, Axl, in intercellular adhesion and signalling in cutaneous squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 129 , S79 - S79 .
Vlachou C, O'Toole EA, Kelsell DP, Batta K ( 2009 ) . A new autosomal dominant pure hair-nail ectodermal dysplasia showing variable expression within a family . BRITISH JOURNAL OF DERMATOLOGY . vol. 161 , 126 - 126 .
Singh M, Heseltine R, Millar J, Cerio R, Breuer J, O'Toole EA ( 2009 ) . Localization of varicella-zoster virus reactivation in neuronal and adnexal structures in skin . BRITISH JOURNAL OF DERMATOLOGY . vol. 161 , 88 - 88 .
Martins VL, Vyas JJ, Chen M, Purdie K, Mein CA, South AP, Storey A, McGrath JA et al. ( 2009 ) . Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen . J Cell Sci vol. 122 , ( Pt 11 ) 1788 - 1799 .
Sinclair C, O'Toole EA, Paige D, El Bashir H, Robinson J, Dobson R, Lench N, Stevens HP et al. ( 2009 ) . Filaggrin mutations are associated with ichthyosis vulgaris in the Bangladeshi population . Br J Dermatol vol. 160 , ( 5 ) 1113 - 1115 .
Papadakis ES, Vyas JJ, Patel N, Ghali L, Storey A, O'Toole EA ( 2009 ) . An antiapoptotic role for the receptor tyrosine kinase Axl in cutaneous squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 160 , 924 - 924 .
Martins VL, Vyas JJ, Chen M, Purdie KJ, South AP, Storey A, McGrath JA, O'Toole EA ( 2009 ) . Mechanisms of increased invasion of cutaneous squamous cell carcinoma cells with loss of type VII collagen . BRITISH JOURNAL OF DERMATOLOGY . vol. 160 , 906 - 906 .
Rajpopat S, O'Toole EA, Kelsell DP ( 2009 ) . Prenatal diagnosis of harlequin ichthyosis, the search for novel mutations and a review of clinical outcome . BRITISH JOURNAL OF DERMATOLOGY . vol. 160 , 923 - 923 .
Cichon MA, Papadakis ES, MacKenzie IC, O'Toole EA ( 2009 ) . The role of the receptor tyrosine kinase, Axl, intercellular adhesion and signalling in cancer . BRITISH JOURNAL OF DERMATOLOGY . vol. 160 , 914 - 914 .
Amarasingham EN, Martins VL, Papadakis ES, O'Toole EA ( 2009 ) . The role of type VII collagen in apoptosis in skin . BRITISH JOURNAL OF DERMATOLOGY . vol. 160 , 913 - 914 .
Singh M, Breuer J, Heseltine R, Millar J, Philpott MP, O'Toole EA ( 2009 ) . Varicella-zoster virus infection in skin shows prominent involvement of adnexal stem cell compartments . BRITISH JOURNAL OF DERMATOLOGY . vol. 160 , 904 - 904 .
Thomas AC, Tattersall D, Norgett EE, O'Toole EA, Kelsell DP ( 2009 ) . Premature terminal differentiation and a reduction in specific proteases associated with loss of ABCA12 in Harlequin ichthyosis . Am J Pathol vol. 174 , ( 3 ) 970 - 978 .
O'Toole E ( 2008 ) . Epidermal basement membrane-mesenchymal interactions . EXP DERMATOL vol. 17 , ( 10 ) 880 - 881 .
Majmudar V, O'Toole E, Khorshid M, Harrison A ( 2008 ) . Birt-Hogg-Dube syndrome: a systemic syndrome with initial presentation to dermatologists . BRITISH JOURNAL OF DERMATOLOGY . vol. 159 , 93 - 93 .
Webber N, O'Toole EA, Paige DG, Rosser E ( 2008 ) . Cutaneous features associated with microcephalic osteodysplastic primordial dwarfism type II . Pediatr Dermatol vol. 25 , ( 3 ) 401 - 402 .
Papadakis ES, Vyas JJ, Storey A, O'Toole EA ( 2008 ) . A role for the receptor tyrosine kinase, Axl, in cutaneous squamous cell carcinoma survival . BRITISH JOURNAL OF DERMATOLOGY . vol. 158 , 883 - 883 .
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Neill GW, Harrison WJ, Ikram MS, Williams TDL, Bianchi LS, Nadendla SK, Green JL, Ghali L et al. ( 2008 ) . GLI1 repression of ERK activity correlates with colony formation and impaired migration in human epidermal keratinocytes . Carcinogenesis vol. 29 , ( 4 ) 738 - 746 .
Neill GW, Harrison W, Ikram M, Williams T, Bianchi L, Nadendla S, O'Toole EA, Aberger F et al. ( 2008 ) . GLI1 repression of epidermal growth factor receptor extracellular signal-regulated kinase signalling may account for the poor metastatic potential of basal cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 158 , 884 - 884 .
Webber NK, Elston CM, O'Toole EA ( 2008 ) . Generalized pustular psoriasis and cryptogenic organizing pneumonia . Br J Dermatol vol. 158 , ( 4 ) 853 - 854 .
Kelsell DP, Thomas AC, Tattersall D, O'Toole EA ( 2008 ) . Genetic and functional mechanisms in harlequin ichthyosis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 128 , S116 - S116 .
Singh M, Breuer J, Cerio R, Millar J, Philpott MP, O'Toole EA ( 2008 ) . Immunohistochemical study of varicella-zoster virus infection in skin confirms prominent involvement of the follicular epithelium . BRITISH JOURNAL OF DERMATOLOGY . vol. 158 , 892 - 892 .
Martins VL, Vyas JJ, Purdie KJ, Chen M, McGrath JA, Storey A, South AP, O'Toole EA ( 2008 ) . Loss of type VII collagen in squamous cell carcinoma results in increased invasion with disorganized epithelial differentiation and epithelial-mesenchymal transition . BRITISH JOURNAL OF DERMATOLOGY . vol. 158 , 882 - 882 .
Martin VI, Vyas JJ, Chen M, Purdie K, South AP, Storey A, McGrath JA, O'Toole EA ( 2008 ) . Mechanisms of increased invasion of cutaneous squamous cell carcinoma with loss of type VII collagen . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 128 , S37 - S37 .
Singh M, Breuer J, Cerio R, Millar J, Philpott MP, O'Toole EA ( 2008 ) . Varicella zoster virus colocalizes within adnexal stem cell compartments of skin . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 128 , S194 - S194 .
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O'Toole EA, van Koningsveld R, Chen M, Woodley DT ( 2008 ) . Hypoxia induces epidermal keratinocyte matrix metalloproteinase-9 secretion via the protein kinase C pathway . J Cell Physiol vol. 214 , ( 1 ) 47 - 55 .
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Neill W, Harrison WJ, Ikram MS, Williams TDL, Green JL, Ghali L, Frischauf AM, O'Toole EA et al. ( 2007 ) . Attenuation of EGFR-ERK signalling by GLI1 highlights a mechanism to promote the epithelial phenotype and may account for the poor metastatic potential of basal cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 127 , S91 - S91 .
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Man YKS, Trolove C, Tattersall D, Thomas AC, Papakonstantinopoulou A, Patel D, Scott C, Chong J et al. ( 2007 ) . A deafness-associated mutant human connexin 26 improves the epithelial barrier in vitro . J Membr Biol vol. 218 , ( 1-3 ) 29 - 37 .
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Cox GA, Pourreyron C, Volz A, O'Toole EA, Chen M, Bruckner-Tuderman L, Salas-Alanis JC, Leigh IM et al. ( 2007 ) . Does the presence or absence of type VII collagen expression in individuals with recessive dystrophic epidermolysis bullosa have implications for the risk of developing squamous cell carcinoma? . BRITISH JOURNAL OF DERMATOLOGY . vol. 157 , 12 - 13 .
Sinclair C, O'Toole EA, Paige D, Mein CA, Kelsell DP ( 2007 ) . A comprehensive survey of 28 candidate genes for atopic dermatitis using a hapTAG approach in a unique Bangladeshi population of East London . BRITISH JOURNAL OF DERMATOLOGY . vol. 156 , 1103 - 1103 .
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van Koningsveld R, Fitchett CJ, Rugg EL, Kelsell DP, O'Toole EA ( 2007 ) . The effect of pachyonychia congenita type 1 mutations in keratinocyte adhesion and desmosome formation and associated signal transduction . BRITISH JOURNAL OF DERMATOLOGY . vol. 156 , 1099 - 1099 .
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Martins VL, Vyas JJ, Purdie KJ, Chen M, McGrath JA, Storey A, South AP, O'Toole EA ( 2007 ) . Knock-down of type VII collagen in squamous cell carcinoma increases migration and invasion with loss of differentiation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 127 , S35 - S35 .
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Man S, Unsworth H, Aasen T, Trolove C, Tattersall D, Thomas A, O'Toole E, Navsaria H et al. ( 2006 ) . Connexins have isoform and tissue specific functions and are critical for skin differentiation, migration, wound healing and bacterial invasion . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 10 - 10 .
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Van Koningsveld R, Fitchett CJ, Rugg EL, O'Toole EA ( 2006 ) . Functional effects of pachyonychia congenita type I mutations on keratinocyte migration and the actin cytoskeleton . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 3 - 3 .
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Martins VL, Vyas JJ, Purdie KJ, Chen M, McGrath JA, Storey A, South AP, O'Toole EA ( 2006 ) . Type VII collagen regulates squamous cell carcinoma cell migration and proteinase expression . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 87 - 87 .
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Fitchett CJ, Van Koningsveld R, Rugg EL, O'Toole EA ( 2006 ) . Functional effects of pachyonychia congenita type I mutations on keratinocyte migration . BRITISH JOURNAL OF DERMATOLOGY . vol. 155 , 235 - 236 .
Thomas AC, Norgett EE, Cullup T, O'Toole EA, Kelsell DP ( 2006 ) . Genetic and functional mechanisms of ABCA12-associated harlequin ichthyosis . BRITISH JOURNAL OF DERMATOLOGY . vol. 155 , 236 - 236 .
Vyas JJ, Proby CM, Storey A, O'Toole EA ( 2006 ) . Signalling mechanisms of squamous cell carcinoma in an in vitro model of squamous cell carcinogenesis . BRITISH JOURNAL OF DERMATOLOGY . vol. 155 , 237 - 237 .
Green J, Ikram M, Vyas J, Patel N, Proby CM, Ghali L, Leigh IM, O'Toole EA et al. ( 2006 ) . Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours . Br J Cancer vol. 94 , ( 10 ) 1446 - 1451 .
Rajpopat S, O'Tooele E, Paige D ( 2006 ) . Harlequin ichthyosis: A new understanding . JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY . vol. 54 , AB123 - AB123 .
Wierzbicka E, Robert M, Herbreteau D, Lorette G, Jury CS, Mealyea M, McHenry P, Lever R et al. ( 2006 ) . The French Society of Dermatology. Joint session between the French Society of Pediatric Dermatology, the French Society of Dermatology and the British Society of Paediatric Dermatology . Annales de Dermatologie et de Venereologie vol. 133 , ( 6-7 ) 614 - 629 .
Common JEA, O'Toole EA, Leigh IM, Thomas A, Griffiths WAD, Venning V, Grabczynska S, Peris Z et al. ( 2005 ) . Clinical and genetic heterogeneity of erythrokeratoderma variabilis . J Invest Dermatol vol. 125 , ( 5 ) 920 - 927 .
Common JEA, Bitner-Glindzicz M, O'Toole EA, Barnes MR, Jenkins L, Forge A, Kelsell DP ( 2005 ) . Specific loss of connexin 26 expression in ductal sweat gland epithelium associated with the deletion mutation del(GJB6-D13S1830) . Clin Exp Dermatol vol. 30 , ( 6 ) 688 - 693 .
Leachman SA, Kaspar RL, Fleckman P, Florell SR, Smith FJD, McLean WHI, Lunny DP, Milstone LM et al. ( 2005 ) . Clinical and pathological features of pachyonychia congenita . J Investig Dermatol Symp Proc . vol. 10 , 3 - 17 .
Lau KG, Hattori Y, Chopra S, O'Toole EA, Storey A, Nagai T, Maitani Y ( 2005 ) . Ultra-deformable liposomes containing bleomycin: in vitro stability and toxicity on human cutaneous keratinocyte cell lines . Int J Pharm vol. 300 , ( 1-2 ) 4 - 12 .
Kelsell DP, Norgett EE, Unsworth H, Teh MT, Cullup T, Mein CA, Dopping-Hepenstal PJ, Kennedy CT et al. ( 2005 ) . Clinical and molecular features of Harlequin ichthyosis . BRITISH JOURNAL OF DERMATOLOGY . vol. 153 , 5 - 5 .
Thein M, Khorshid SM, Cerio R, O'Toole EA ( 2005 ) . Unusual histopathology in cutaneous sarcoidosis mimicking late secondary syphilis . BRITISH JOURNAL OF DERMATOLOGY . vol. 153 , 70 - 70 .
Ismail F, O'Toole EA, McGregor JM, Khorshid SM ( 2005 ) . Unusual distribution of punctate dysplastic keratoses and skin cancers in sunbed users: a report of three cases . Br J Dermatol vol. 152 , ( 6 ) 1374 - 1376 .
Kelsell DP, Norgett EE, Unsworth H, Teh M-T, Cullup T, Mein CA, Dopping-Hepenstal PJ, Dale BA et al. ( 2005 ) . Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis . Am J Hum Genet vol. 76 , ( 5 ) 794 - 803 .
Di W-L, Gu Y, Common JEA, Aasen T, O'Toole EA, Kelsell DP, Zicha D ( 2005 ) . Connexin interaction patterns in keratinocytes revealed morphologically and by FRET analysis . J Cell Sci vol. 118 , ( Pt 7 ) 1505 - 1514 .
Common JEA, Thomas AC, O'Toole EA, Kelsell DP ( 2005 ) . Evidence for a key role of Connexin 26 in early epidermal differentiation . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 855 - 855 .
Fitchett CJ, Rugg EL, Gilfillan N, Leigh IM, O'Toole EA ( 2005 ) . Functional effects of pachyonychia congenita type I mutations on keratinocyte migration and proliferation . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 835 - 835 .
Fitchett CJ, Rugg EL, Gilfillan N, Leigh IM, O'Toole EA ( 2005 ) . Functional effects of pachyonychia congenital type I mutations on keratinocyte motility and proliferation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 124 , A95 - A95 .
Neill GW, Kasper M, Williams T, Ikram M, Ghali L, Green J, Quinn A, Frischauf A et al. ( 2005 ) . Gli1 co-operates with EGFR signalling to induce a neuronal phenotype in keratinocytes . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 844 - 844 .
Patel N, Vyas J, Ghali L, Green J, Cerio R, Storey A, O'Toole EA ( 2005 ) . Increased Axl expression in invasive squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 843 - 843 .
Ong C, Di WL, O'Toole EA, Green A, Callard R, Harper J ( 2005 ) . LEKTI is required for skin barrier integrity and acts via the PAR-2 signalling pathway . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 851 - 852 .
Vyas J, Ahmed W, Jayazeri M, Marshall JF, Proby CM, Storey A, O'Toole EA ( 2005 ) . Mechanisms of migration and invasion of squamous cell carcinoma in an in vitro model of squamous cell carcinogenesis . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 843 - 843 .
Vyas JJ, Ahmed W, Jayazeri M, Baksh N, Marshall JF, Proby CM, Storey A, O'Toole EA ( 2005 ) . Migration and invasion mechanisms in an in vitro model of squamous cell carcinogenesis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 124 , A22 - A22 .
Ong C, O'Toole EA, Ghali L, Malone M, Smith VV, Callard R, Harper JI ( 2004 ) . LEKTI demonstrable by immunohistochemistry of the skin: a potential diagnostic skin test for Netherton syndrome . Br J Dermatol vol. 151 , ( 6 ) 1253 - 1257 .
Ong C, Di WL, Mazereeuw J, Callard R, O'Toole E, Harper J ( 2004 ) . LEKTI, terminal differentiation of keratinocytes and skin barrier formation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 123 ,
Neill G, Ikram MS, Green JL, Quinn AG, O'Toole E, Philpott MP ( 2004 ) . Gli1 co-operates with EGFR-Sre signalling to induce a fibroblastoid phenotype in primary keratinocytes . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 122 , A17 - A17 .
Ismail FF, Khorshid SM, O'Toole EA, McGregor JM ( 2004 ) . Sunbed related dysplastic keratosis - A report of three cases . JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY . vol. 50 , P122 - P122 .
Common JEA, Di W-L, Davies D, Galvin H, Leigh IM, O'Toole EA, Kelsell DP ( 2003 ) . Cellular mechanisms of mutant connexins in skin disease and hearing loss . Cell Commun Adhes . vol. 10 , 347 - 351 .
Jolliffe VM, O'Toole EA, Common JE, Kelsell DP, Yell JA, Paige DG, McKenna KE, Leigh IM ( 2003 ) . Clinical and molecular features of keratitis-ichthyosis-deafness syndrome . BRITISH JOURNAL OF DERMATOLOGY . vol. 149 , 80 - 80 .
O'Toole E, Lyons I ( 2003 ) . Migration and proteolysis in a cell culture model of squamous epidermal carcinogenesis . BRITISH JOURNAL OF DERMATOLOGY . vol. 148 , 858 - 858 .
Eisman S, O'Toole EA, Jones A, Whittaker SJ ( 2003 ) . Granulomatous mycosis fungoides presenting as an acquired ichthyosis . Clin Exp Dermatol vol. 28 , ( 2 ) 174 - 176 .
Common JEA, Becker D, Di W-L, Leigh IM, O'Toole EA, Kelsell DP ( 2002 ) . Functional studies of human skin disease- and deafness-associated connexin 30 mutations . Biochem Biophys Res Commun vol. 298 , ( 5 ) 651 - 656 .
Hunt SJ, O'toole E, Philips W, Hardman C, Wakelin SH, Walters S ( 2002 ) . A case of childhood sarcoidosis . Clin Exp Dermatol vol. 27 , ( 6 ) 448 - 450 .
Chen M, O'Toole EA, Sanghavi J, Mahmud N, Kelleher D, Weir D, Fairley JA, Woodley DT ( 2002 ) . The epidermolysis bullosa acquisita antigen (type VII collagen) is present in human colon and patients with crohn's disease have autoantibodies to type VII collagen . J Invest Dermatol vol. 118 , ( 6 ) 1059 - 1064 .
Jean-Baptiste S, O'Toole EA, Chen M, Guitart J, Paller A, Chan LS ( 2002 ) . Expression of eotaxin, an eosinophil-selective chemokine, parallels eosinophil accumulation in the vesiculobullous stage of incontinentia pigmenti . Clin Exp Immunol vol. 127 , ( 3 ) 470 - 478 .
Jones J, O'Toole EA, Rustin MHA, Whittaker SJ ( 2002 ) . Case 1. Systematic lupus erythematosus (SLE) . Clin Exp Dermatol vol. 27 , ( 1 ) 78 - 79 .
O'TOOLE EA, Woodley DT, Yurko MA ( 2002 ) . Phosphorylation of focal adhesion kinase (pp125(FAK)) is increased in human keratinocytes induced to migrate by extracellular matrices . Journal of Cellular Physiology vol. 188 , ( 1 ) 24 - 32 .
O'Toole EA ( 2001 ) . Extracellular matrix and keratinocyte migration . Clin Exp Dermatol vol. 26 , ( 6 ) 525 - 530 .
O'Toole EA, Di WL, Common J, Leigh IM, Kelsell DP ( 2001 ) . Heterogeneity of genetic mutations in erythrokeratodermas . J INVEST DERMATOL vol. 117 , ( 3 ) 797 - 797 .
Yurko MA, O'Toole EA, Woodley DT ( 2001 ) . Phosphorylation of focal adhesion kinase (pp125(FAK)) is increased in human keratinocytes induced to migrate by extracellular matrices . J Cell Physiol vol. 188 , ( 1 ) 24 - 32 .
Eisman S, O'Toole EA, Collis C, Rustin MH ( 2001 ) . Zosteriform Kaposi's sarcoma . Clin Exp Dermatol vol. 26 , ( 5 ) 402 - 404 .
Chen M, O'Toole EA, Muellenhoff M, Medina E, Kasahara N, Woodley DT ( 2000 ) . Development and characterization of a recombinant truncated type VII collagen 'minigene'. Implication for gene therapy of dystrophic epidermolysis bullosa . Journal of Biological Chemistry vol. 275 , ( 32 ) 24429 - 24435 .
O'Toole EA, Mak LL, Guitart J, Woodley DT, Hashimoto T, Amagai M, Chan LS ( 2000 ) . Induction of keratinocyte IL-8 expression and secretion by IgG autoantibodies as a novel mechanism of epidermal neutrophil recruitment in a pemphigus variant . Clinical and Experimental Immunology vol. 119 , ( 1 ) 217 - 224 .
Xu L, O'Toole EA, Olivry T, Hernandez C, Peng J, Chen M, Chan LS ( 2000 ) . Molecular cloning of canine bullous pemphigoid antigen 2 cDNA and immunomapping of NC16A domain by canine bullous pemphigoid autoantibodies . Biochimica et Biophysica Acta - Molecular Basis of Disease vol. 1500 , ( 1 ) 97 - 107 .
Chen M, O'Toole EA, Li YY, Woodley DT ( 1999 ) . α2β1 integrin mediates dermal fibroblast attachment to type VII collagen via a 158-amino-acid segment of the NC1 domain . Experimental Cell Research vol. 249 , ( 2 ) 231 - 239 .
O'Toole EA, Powell F, Barnes L ( 1999 ) . Jessner's lymphocytic infiltrate and probable discoid lupus erythematosus occurring separately in two sisters . Clinical and Experimental Dermatology vol. 24 , ( 2 ) 90 - 93 .
O'Toole EA, Kennedy U, Nolan JJ, Young MM, Rogers S, Barnes L ( 1999 ) . Necrobiosis lipoidica: Only a minority of patients have diabetes mellitus . British Journal of Dermatology vol. 140 , ( 2 ) 283 - 286 .
Chen M, Marinkovich MP, Jones JCR, O'Toole EA, Li YY, Woodley DT ( 1999 ) . NC1 domain of type VII collagen binds to the β3 chain of laminin 5 via a unique subdomain within the fibronectin-like repeats . Journal of Investigative Dermatology vol. 112 , ( 2 ) 177 - 183 .
Nasca MR, O'Toole EA, Palicharla P, West DP, Woodley DT ( 1999 ) . Thalidomide increases human keratinocyte migration and proliferation . Journal of Investigative Dermatology vol. 113 , ( 5 ) 720 - 724 .
Xu L, Chen M, Peng J, O'Toole EA, Woodley DT, Chan LS ( 1998 ) . Molecular cloning and characterization of a cDNA encoding canine type VII collagen non-collagenous (NC1) domain, the target antigen of autoimmune disease epidermolysis bullosa acquisita (EBA) . Biochimica et Biophysica Acta - Molecular Basis of Disease vol. 1408 , ( 1 ) 25 - 34 .
Sung CC, O'Toole EA, Lannutti BJ, Hunt J, O'Gorman M, Woodley DT, Paller AS ( 1998 ) . Integrin α5β1 expression is required for inhibition of keratinocyte migration by ganglioside GT1b . Experimental Cell Research vol. 239 , ( 2 ) 311 - 319 .
Fishman DA, Kearns A, Chilukuri K, Bafetti LM, O'Toole EA, Georgacopoulos J, Ravosa MJ, Stack MS ( 1998 ) . Metastatic dissemination of human ovarian epithelial carcinoma is promoted by α2β1-integrin-mediated interaction with type I collagen . Invasion and Metastasis vol. 18 , ( 1 ) 15 - 26 .
O'Toole EA, Marinkovich MP, Peavey CL, Amieva MR, Furthmayr H, Mustoe TA, Woodley DT ( 1997 ) . Hypoxia increases human keratinocyte motility on connective tissue . Journal of Clinical Investigation vol. 100 , ( 11 ) 2881 - 2891 .
O'Toole EA, Nasca MR, Palicharla P, West DP, Woodley DT ( 1997 ) . Thalidomide increases keratinocyte proliferation and chemokine secretion in vitro . Clinical Pharmacology and Therapeutics vol. 61 , ( 2 )
O'Toole EA, Marinkovich MP, Hoeffler WK, Furthmayr H, Woodley DT ( 1997 ) . Laminin-5 inhibits human keratinocyte migration . Experimental Cell Research vol. 233 , ( 2 ) 330 - 339 .
Chen M, Marinkovich MP, Veis A, Cai X, Rao CN, O'Toole EA, Woodley DT ( 1997 ) . Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components . Journal of Biological Chemistry vol. 272 , ( 23 ) 14516 - 14522 .
Chen M, Goyal S, Cai X, O'Toole EA, Woodley DT ( 1997 ) . Modulation of type VII collagen (anchoring fibril) expression by retinoids in human skin cells . Biochimica et Biophysica Acta - Gene Structure and Expression vol. 1351 , ( 3 ) 333 - 340 .
Chen M, Chan LS, Cai X, O'Toole EA, Sample JC, Woodley DT ( 1997 ) . Development of an ELISA for rapid detection of anti-type VII collagen autoantibodies in epidermolysis bullosa acquisita . Journal of Investigative Dermatology vol. 108 , ( 1 ) 68 - 72 .
O'Toole EA, Mooney EE, Walsh JB, Sweeney EC, Barnes L ( 1997 ) . Disseminated herpes zoster in the elderly . Irish Journal of Medical Science vol. 166 , ( 3 ) 141 - 142 .
Chen M, Petersen MJ, Li HL, Cai XY, O'Toole EA, Woodley DT ( 1997 ) . Ultraviolet A irradiation upregulates type VII collagen expression in human dermal fibroblasts . Journal of Investigative Dermatology vol. 108 , ( 2 ) 125 - 128 .
Rao CN, Reddy P, Liu Y, O'Toole E, Reeder D, Foster DC, Kisiel W, Woodley DT ( 1996 ) . Extracellular matrix-associated serine protease inhibitors (M(r) 33,000, 31,000, and 27,000) are single-gene products with differential glycosylation: cDNA cloning of the 33-kDa inhibitor reveals its identity to tissue factor pathway inhibitor-2 . Archives of Biochemistry and Biophysics vol. 335 , ( 1 ) 82 - 92 .
Cha D, O'Brien P, O'Toole EA, Woodley DT, Hudson LG ( 1996 ) . Enhanced modulation of keratinocyte motility by transforming growth factor-α (TGF-α) relative to epidermal growth factor (EGF) . Journal of Investigative Dermatology vol. 106 , ( 4 ) 590 - 597 .
O'Toole EA, Goel M, Woodley DT ( 1996 ) . Hydrogen peroxide inhibits human keratinocyte migration . Dermatologic Surgery vol. 22 , ( 6 ) 525 - 529 .
Stinson J, O'Toole E, Cooke T, D'Arcy G, Hall M, Barnes L, Feely J ( 1995 ) . Cholesterol and lipoprotein (a) levels in psoriasis . Irish medical journal vol. 88 , ( 4 ) 128 - 129 .
O'Toole EA, Deasy P, Watson R ( 1995 ) . Cutis Marmorata Telangiectatica Congenita Associated with a Double Aortic Arch . Pediatric Dermatology vol. 12 , ( 4 ) 348 - 350 .
O'Toole EA, Stephens R, Young MM, Tanner A, Barnes L ( 1995 ) . Subungual melanoma: A relation to direct injury? . Journal of the American Academy of Dermatology vol. 33 , ( 3 ) 525 - 528 .
O'Toole EA, Gormally S, Drumm B, Monaghan H, Watson R ( 1995 ) . Unilateral Beau's Lines in Childhood Reflex Sympathetic Dystrophy . Pediatric Dermatology vol. 12 , ( 3 ) 245 - 247 .
Buckley D, Rogers S, O'Connor W, Murphy G, Darby C, O'Moore R, Mulcahy F, Barnes L et al. ( 1994 ) . Annual Jacob Medal Meeting Proceedings of Meeting held 13th May, 1994 . Irish Journal of Medical Science vol. 163 , ( 8 ) 400 - 401 .