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Research

Publications: Dr Olivier Marches

Goddard PJ, Sanchez-Garrido J, Slater SL, Kalyan M, Ruano-Gallego D, Marchès O, Fernández LÁ, Frankel G et al. ( 2019 ) . Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages . Cell Rep vol. 27 , ( 4 ) 1008 - 1017.e6 .
Rossignol A, Roche SM, Virlogeux-Payant I, Wiedemann A, Grépinet O, Fredlund J, Trotereau J, Marchès O et al. ( 2014 ) . Deciphering why Salmonella Gallinarum is less invasive in vitro than Salmonella Enteritidis . Vet Res vol. 45 ,
Brooke MA, Etheridge SL, Kaplan N, Simpson C, O'Toole EA, Ishida-Yamamoto A, Marches O, Getsios S et al. ( 2014 ) . iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function . Hum Mol Genet vol. 23 , ( 15 ) 4064 - 4076 .
Rossignol A, Roche SM, Virlogeux-Payant I, Wiedemann A, Grépinet O, Fredlund J, Trotereau J, Marchès O et al. ( 2014 ) . Deciphering why . Veterinary Research vol. 45 , ( 1 )
Pearson JS, Giogha C, Ong SY, Kennedy CL, Kelly M, Robinson KS, Lung TWF, Mansell A et al. ( 2013 ) . A type III effector antagonizes death receptor signalling during bacterial gut infection . Nature vol. 501 , ( 7466 ) 247 - 251 .
Simpson C, Brooke M, Marches O, Kelsell D ( 2013 ) . A specific requirement for a disintegrin and metalloprotease (ADAM) 17 in protection against cutaneous Staphylococcus aureus infection . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S192 - S192 .
Simpson C, Kelsell DP, Marchès O ( 2013 ) . Connexin 26 facilitates gastrointestinal bacterial infection in vitro . Cell Tissue Res vol. 351 , ( 1 ) 107 - 116 .
Vossenkämper A, Macdonald TT, Marchès O ( 2011 ) . Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system . J Inflamm (Lond) vol. 8 ,
Pearson JS, Riedmaier P, Marchès O, Frankel G, Hartland EL ( 2011 ) . A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation . Mol Microbiol vol. 80 , ( 1 ) 219 - 230 .
Arbeloa A, Oates CV, Marchès O, Hartland EL, Frankel G ( 2011 ) . Enteropathogenic and enterohemorrhagic Escherichia coli type III secretion effector EspV induces radical morphological changes in eukaryotic cells . Infect Immun vol. 79 , ( 3 ) 1067 - 1076 .
Vossenkämper A, Marchès O, Fairclough PD, Warnes G, Stagg AJ, Lindsay JO, Evans PC, Luong LA et al. ( 2010 ) . Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE . J Immunol vol. 185 , ( 7 ) 4118 - 4127 .
Munera D, Crepin VF, Marches O, Frankel G ( 2010 ) . N-terminal type III secretion signal of enteropathogenic Escherichia coli translocator proteins . J Bacteriol vol. 192 , ( 13 ) 3534 - 3539 .
Hemrajani C, Berger CN, Robinson KS, Marchès O, Mousnier A, Frankel G ( 2010 ) . NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection . Proc Natl Acad Sci U S A vol. 107 , ( 7 ) 3129 - 3134 .
Hemrajani C, Marches O, Wiles S, Girard F, Dennis A, Dziva F, Best A, Phillips AD et al. ( 2008 ) . Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut . Infect Immun vol. 76 , ( 11 ) 4804 - 4813 .
Marchès O, Covarelli V, Dahan S, Cougoule C, Bhatta P, Frankel G, Caron E ( 2008 ) . EspJ of enteropathogenic and enterohaemorrhagic Escherichia coli inhibits opsono-phagocytosis . Cell Microbiol vol. 10 , ( 5 ) 1104 - 1115 .
Bai L, Schüller S, Whale A, Mousnier A, Marches O, Wang L, Ooka T, Heuschkel R et al. ( 2008 ) . Enteropathogenic Escherichia coli O125:H6 triggers attaching and effacing lesions on human intestinal biopsy specimens independently of Nck and TccP/TccP2 . Infect Immun vol. 76 , ( 1 ) 361 - 368 .
Tobe T, Beatson SA, Taniguchi H, Abe H, Bailey CM, Fivian A, Younis R, Matthews S et al. ( 2006 ) . An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination . Proc Natl Acad Sci U S A vol. 103 , ( 40 ) 14941 - 14946 .
Vlisidou I, Marchés O, Dziva F, Mundy R, Frankel G, Stevens MP ( 2006 ) . Identification and characterization of EspK, a type III secreted effector protein of enterohaemorrhagic Escherichia coli O157:H7 . FEMS Microbiol Lett vol. 263 , ( 1 ) 32 - 40 .
Marchès O, Batchelor M, Shaw RK, Patel A, Cummings N, Nagai T, Sasakawa C, Carlsson SR et al. ( 2006 ) . EspF of enteropathogenic Escherichia coli binds sorting nexin 9 . J Bacteriol vol. 188 , ( 8 ) 3110 - 3115 .
Kelly M, Hart E, Mundy R, Marches O, Wiles S, Badea L, Luck S, Tauschek M et al. ( 2006 ) . Essential role of the type III secretion system effector NleB in colonization of mice by Citrobacter rodentium . INFECT IMMUN vol. 74 , ( 4 ) 2328 - 2337 .
Marchés O, Wiles S, Dziva F, La Ragione RM, Schüller S, Best A, Phillips AD, Hartland EL et al. ( 2005 ) . Characterization of two non-locus of enterocyte effacement-encoded type III-translocated effectors, NleC and NleD, in attaching and effacing pathogens . Infect Immun vol. 73 , ( 12 ) 8411 - 8417 .
Garmendia J, Phillips AD, Carlier M-F, Chong Y, Schüller S, Marches O, Dahan S, Oswald E et al. ( 2004 ) . TccP is an enterohaemorrhagic Escherichia coli O157:H7 type III effector protein that couples Tir to the actin-cytoskeleton . Cell Microbiol vol. 6 , ( 12 ) 1167 - 1183 .
Marchès O, Ledger TN, Boury M, Ohara M, Tu X, Goffaux F, Mainil J, Rosenshine I et al. ( 2003 ) . Enteropathogenic and enterohaemorrhagic Escherichia coli deliver a novel effector called Cif, which blocks cell cycle G2/M transition . Mol Microbiol vol. 50 , ( 5 ) 1553 - 1567 .
Boullier S, Nougayrède J-P, Marchès O, Tasca C, Boury M, Oswald E, De Rycke J, Milon A ( 2003 ) . Genetically engineered enteropathogenic Escherichia coli strain elicits a specific immune response and protects against a virulent challenge . Microbes Infect vol. 5 , ( 10 ) 857 - 867 .
Beutin L, Marchés O, Bettelheim KA, Gleier K, Zimmermann S, Schmidt H, Oswald E ( 2003 ) . HEp-2 cell adherence, actin aggregation, and intimin types of attaching and effacing Escherichia coli strains isolated from healthy infants in Germany and Australia . Infect Immun vol. 71 , ( 7 ) 3995 - 4002 .
Stevens MP, Marchès O, Campbell J, Huter V, Frankel G, Phillips AD, Oswald E, Wallis TS ( 2002 ) . Intimin, tir, and shiga toxin 1 do not influence enteropathogenic responses to shiga toxin-producing Escherichia coli in bovine ligated intestinal loops . Infect Immun vol. 70 , ( 2 ) 945 - 952 .
Nougayrède JP, Boury M, Tasca C, Marchès O, Milon A, Oswald E, De Rycke J ( 2001 ) . Type III secretion-dependent cell cycle block caused in HeLa cells by enteropathogenic Escherichia coli O103 . Infect Immun vol. 69 , ( 11 ) 6785 - 6795 .