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Research

Publications: Prof Nicholas Lemoine

Lu S, Zhang Z, Du P, Chard LS, Yan W, El Khouri M, Wang Z, Zhang Z et al. ( 2021 ) . Erratum: A virus-infected, reprogrammed somatic cell-derived tumor cell (VIReST) vaccination regime can prevent initiation and progression of pancreatic cancer (Clinical Cancer Research (2020) 26 (465-476) DOI: 10.1158/1078-0432.CCR-19-1395) . Clinical Cancer Research vol. 27 , ( 9 )
Zhang Z, Zhang C, Miao J, Wang Z, Wang Z, Cheng Z, Wang P, Dunmall LSC et al. ( 2020 ) . A Tumor-Targeted Replicating Oncolytic Adenovirus Ad-TD-nsIL12 as a Promising Therapeutic Agent for Human Esophageal Squamous Cell Carcinoma . Cells vol. 9 , ( 11 )
Martin L-A, Lemoine NR ( 2020 ) . Cancer gene therapy I: genetic intervention strategies . Gene Therapy ,
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al. ( 2020 ) . Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer . npj Breast Cancer vol. 6 , ( 1 )
Zhang Z, Lu S, Dunmall LSC, Wang Z, Cheng Z, Zhang Z, Yan W, Chu Y et al. ( 2020 ) . Treatment and Prevention of Lung Cancer Using a Virus-Infected Reprogrammed Somatic Cell-Derived Tumor Cell Vaccination (VIReST) Regime . Frontiers in Immunology vol. 11 ,
Ahmed J, Chard LS, Yuan M, Wang J, Howells A, Li Y, Li H, Zhang Z et al. ( 2020 ) . Erratum: A new oncolytic Vaccinia virus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery (J ImmunoTher Cancer (2020) 8 (e000415) DOI: 10.1136/jitc-2019-000415) . Journal for ImmunoTherapy of Cancer vol. 8 , ( 1 )
Ahmed J, Chard LS, Yuan M, Wang J, Howells A, Li Y, Li H, Zhang Z et al. ( 2020 ) . A new oncolytic v accinia virus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery . Journal for ImmunoTherapy of Cancer vol. 8 , ( 1 )
Ferguson MS, Chard Dunmall LS, Gangeswaran R, Marelli G, Tysome JR, Burns E, Whitehead MA, Aksoy E et al. ( 2020 ) . Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus . Molecular Therapy vol. 28 , ( 5 ) 1263 - 1275 .
Cutmore LC, Brown NF, Raj D, Chauduri S, Wang P, Maher J, Wang Y, Lemoine NR et al. ( 2020 ) . Pancreatic Cancer UK Grand Challenge: Developments and challenges for effective CAR T cell therapy for pancreatic ductal adenocarcinoma . Pancreatology
Lu S, Zhang Z, Du P, Chard LS, Yan W, Khouri ME, Wang Z, Zhang Z et al. ( 2020 ) . A virus-infected, reprogrammed somatic cell–derived tumor cell (VIREST) vaccination regime can prevent initiation and progression of pancreatic cancer . Clinical Cancer Research vol. 26 , ( 2 ) 465 - 476 .
Oscanoa J, Sivapalan L, Gadaleta E, Dayem Ullah AZ, Lemoine NR, Chelala C ( 2020 ) . SNPnexus: A web server for functional annotation of human genome sequence variation (2020 update) . Nucleic Acids Research vol. 48 , ( W1 ) W185 - W192 .
Ottaviani S, Stebbing J, Frampton AE, Zagorac S, Krell J, de Giorgio A, Trabulo SM, Nguyen VTM et al. ( 2019 ) . Author Correction: TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression . Nat Commun vol. 10 , ( 1 ) 3738 - 3738 .
Hallden G, Wang Y, Wong H-H, Lemoine NR ( 2019 ) . ONCOLYTIC ADENOVIRUSES FOR CANCER GENE THERAPY . Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology ,
( 2019 ) . Erratum . Int J Cancer vol. 144 , ( 10 )
Ottaviani S, Stebbing J, Frampton AE, Zagorac S, Krell J, De Giorgio A, Trabulo SM, Nguyen VTM et al. ( 2018 ) . TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression . Nature Communications vol. 9 , ( 1 )
Dayem Ullah AZ, Oscanoa J, Wang J, Nagano A, Lemoine NR, Chelala C ( 2018 ) . SNPnexus: Assessing the functional relevance of genetic variation to facilitate the promise of precision medicine . Nucleic Acids Research vol. 46 , ( W1 ) W109 - W113 .
Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A et al. ( 2018 ) . A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia . EMBO Mol Med
Marelli G, Howells A, Lemoine NR, Wang Y ( 2018 ) . Oncolytic Viral Therapy and the Immune System: A Double-Edged Sword Against Cancer . Frontiers in Immunology vol. 9 , 866 - 866 .
Wang P, Li X, Wang J, Gao D, Li Y, Li H, Chu Y, Zhang Z et al. ( 2018 ) . Erratum: Author Correction: Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent (Nature communications (2017) 8 1 (1395)) . Nature communications vol. 9 , ( 1 )
Wang J, Dumartin L, Mafficini A, Ulug P, Sangaralingam A, Alamiry NA, Radon TP, Salvia R et al. ( 2017 ) . Splice variants as novel targets in pancreatic ductal adenocarcinoma . Scientific Reports vol. 7 , ( 1 )
Wang P, Li X, Wang J, Gao D, Li Y, Li H, Chu Y, Zhang Z et al. ( 2017 ) . Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent . Nat Commun vol. 8 , ( 1 ) 1395 - 1395 .
Marzec J, Dayem Ullah AZ, Pirrò S, Gadaleta E, Crnogorac-Jurcevic T, Lemoine NR, Kocher HM, Chelala C ( 2017 ) . The Pancreatic Expression Database: 2018 update . Nucleic Acids Res vol. 46 , ( D1 ) D1107 - D1110 .
Spurrell E, Gangeswaran R, Wang P, Cao F, Gao D, Feng B, Wold W, Tollefson A et al. ( 2017 ) . Erratum: STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus [Journal of Virology, 88, 4, (2014) (2291-2300)] DOI: 10.1128/JVI.02829-13 . Journal of Virology vol. 91 , ( 20 )
Howells A, Marelli G, Lemoine NR, Wang Y ( 2017 ) . Oncolytic Viruses-Interaction of Virus and Tumor Cells in the Battle to Eliminate Cancer . Front Oncol vol. 7 , 195 - 195 .
Glorioso JC, Lemoine N ( 2017 ) . Gene therapy-from small beginnings to where we are now . Gene Therapy vol. 24 , ( 9 ) 495 - 496 .
Sangaralingam A, Dayem Ullah AZ, Marzec J, Gadaleta E, Nagano A, Ross-Adams H, Wang J, Lemoine NR et al. ( 2017 ) . 'Multi-omic' data analysis using O-miner . Brief Bioinform
Webb ES, Liu P, BALEEIRO R, Lemoine NR, Yuan M, Wang Y ( 2017 ) . Immune checkpoint inhibitors in cancer therapy . Journal of Biomedical Research
Szlosarek PW, Steele JP, Nolan L, Gilligan D, Taylor P, Spicer J, Lind M, Mitra S et al. ( 2017 ) . Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial . JAMA oncology vol. 3 , ( 1 ) 58 - 66 .
Szlosarek PW, Steele JP, Nolan L, Gilligan D, Taylor P, Spicer J, Lind M, Mitra S et al. ( 2017 ) . Arginine deprivation with pegylated arginine deiminase in patients with argininosuccinate synthetase 1-deficient malignant pleural mesothelioma a randomized clinical trial . JAMA Oncology vol. 3 , ( 1 ) E1 - E9 .
CRNOGORAC-JURCEVIC T, Dumartin L, Alrawashdeh W, Trabulo SM, Radon TP, Steiger K, Feakins RM, di Magliano MP et al. ( 2016 ) . ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation . Oncogene
Yuan M, Wang P, Chard LS, Lemoine NR, Wang Y ( 2016 ) . A simple and efficient approach to construct mutant vaccinia virus vectors . Journal of Visualized Experiments vol. 2016 , ( 116 )
Carapuça EF, Gemenetzidis E, Feig C, Bapiro TE, Williams MD, Wilson AS, Delvecchio FR, Arumugam P et al. ( 2016 ) . Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma . Journal of Pathology vol. 239 , ( 3 ) 286 - 296 .
Pantelidou C, Cherubini G, Lemoine NR, Halldén G ( 2016 ) . The E1B19K-deleted oncolytic adenovirus mutant AdΔ19K sensitizes pancreatic cancer cells to drug-induced DNA-damage by down-regulating Claspin and Mre11 . Oncotarget vol. 7 , ( 13 ) 15703 - 15724 .
Yuan M, Webb E, Lemoine NR, Wang Y ( 2016 ) . CRISPR-Cas9 as a powerful tool for efficient creation of oncolytic viruses . Viruses vol. 8 , ( 3 )
Yaghchi CA, Zhang Z, Alusi G, Lemoine NR, Wang Y ( 2015 ) . Vaccinia virus, a promising new therapeutic agent for pancreatic cancer . Immunotherapy vol. 7 , ( 12 ) 1249 - 1258 .
Radon TP, Massat NJ, Jones R, Alrawashdeh W, Dumartin L, Ennis D, Duffy SW, Kocher HM et al. ( 2015 ) . Identification of a three-biomarker panel in urine for early detection of pancreatic adenocarcinoma . Clinical Cancer Research vol. 21 , ( 15 ) 3512 - 3521 .
Ahmed J, Yuan M, Li Y, Chu Y, Zhang Z, Gao D, Chard LS, Alusi G et al. ( 2015 ) . 420. A Promising Neo-Adjuvant Immuno-Therapeutic Agent for Preventing Cancer Recurrence and Metastasis After Surgery . Molecular Therapy . vol. 23 ,
Ferguson M, Tysome J, Burns E, Whitehead M, Aksoy E, Clear A, Alusi G, Hiley C et al. ( 2015 ) . 649. Targeting Innate Host Immunity Through PI3K Delta for Enhancement of Systemic Delivery of Oncolytic Vaccinia Virus . Molecular Therapy . vol. 23 , s258 - s259 .
Yuan M, Gao X, Chard LS, Ali Z, Ahmed J, Li Y, Liu P, Lemoine NR et al. ( 2015 ) . A marker-free system for highly efficient construction of vaccinia virus vectors using CRISPR Cas9 . Molecular Therapy - Methods and Clinical Development vol. 2 ,
Hughes J, Wang P, Alusi G, Shi H, Chu Y, Wang J, Bhakta V, McNeish I et al. ( 2015 ) . Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus . Gene Therapy
Chard LS, Maniati E, Wang P, Zhang Z, Gao D, Wang J, Cao F, Ahmed J et al. ( 2015 ) . A vaccinia virus armed with interleukin-10 Is a promising therapeutic agent for treatment of murine pancreatic cancer . Clinical Cancer Research vol. 21 , ( 2 ) 405 - 416 .
Yuan M, Zhang W, Wang J, Al Yaghchi C, Ahmed J, Chard L, Lemoine NR, Wang Y ( 2015 ) . Efficiently editing the vaccinia virus genome by using the CRISPR-Cas9 system . Journal of Virology vol. 89 , ( 9 ) 5176 - 5179 .
Ibrahim AM, Wang Y, Lemoine NR ( 2015 ) . Immune-checkpoint blockade: The springboard for immuno-combination therapy . Gene Therapy vol. 22 , ( 11 ) 849 - 850 .
Hughes J, Wang P, Alusi G, Shi H, Chu Y, Wang J, Bhakta V, McNeish I et al. ( 2015 ) . Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus . Gene Therapy vol. 22 , ( 6 ) 476 - 484 .
Chard LS, Lemoine NR, Wang Y ( 2015 ) . New role of Interleukin-10 in enhancing the antitumor efficacy of oncolytic vaccinia virus for treatment of pancreatic cancer . OncoImmunology vol. 4 , ( 9 ) 1 - 3 .
Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T et al. ( 2014 ) . A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma . Genome Medicine vol. 6 , ( 12 )
Pantelidou C, Lemoine N, Hallden G ( 2014 ) . Adenoviruses deleted in the anti-apoptotic E1B19K-gene synergise with DNA-damaging drugs through attenuation of DNA-damage repair responses and checkpoint activation in pancreatic cancer cells . HUMAN GENE THERAPY . vol. 25 , A17 - A17 .
Hughes J, Wang P, Alusi G, Bhakta V, Chu Y, Shi H, McNeish I, McCart A et al. ( 2014 ) . Backbone selection for development of tumour-targeted oncolyti Vaccinia virus for cancer treatment . HUMAN GENE THERAPY . vol. 25 , A22 - A23 .
Ahmed J, Yuan M, Li Y, Chu Y, Shi H, Chard L, Alusi G, Lemoine N et al. ( 2014 ) . A Novel Tumour Selective Oncolytic Vaccinia Virus Lacking the N1L Gene Enhances the Anti-Tumour Immune Response When Used as an Anticancer Therapeutic . MOLECULAR THERAPY . vol. 22 , S248 - S249 .
Coleman SJ, Chioni A-M, Ghallab M, Anderson RK, Lemoine NR, Kocher HM, Grose RP ( 2014 ) . Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion . EMBO Mol Med vol. 6 , ( 4 ) 467 - 481 .
Allen MD, Luong P, Hudson C, Leyton J, Delage B, Ghazaly E, Cutts R, Yuan M et al. ( 2014 ) . Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging . Cancer Res vol. 74 , ( 3 ) 896 - 907 .
Spurrell E, Gangeswaran R, Wang P, Cao F, Gao D, Feng B, Wold W, Tollefson A et al. ( 2014 ) . STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus . J Virol vol. 88 , ( 4 ) 2291 - 2300 .
Ahmed J, Yuan M, Alusi G, Lemoine NR, Wang Y ( 2014 ) . Chapter 16 The Lister Strain of Vaccinia Virus as an Anticancer Therapeutic Agent . Gene Therapy of Cancer ,
Dayem Ullah AZ, Cutts RJ, Ghetia M, Gadaleta E, Hahn SA, Crnogorac-Jurcevic T, Lemoine NR, Chelala C ( 2014 ) . The pancreatic expression database: recent extensions and updates . Nucleic Acids Res vol. 42 , ( Database issue ) D944 - D949 .
Szlosarek PW, Steele J, Sheaff M, Szyszko T, Ellis S, Nolan L, Taylor P, Gilligan D et al. ( 2013 ) . A RANDOMISED PHASE II TRIAL OF PEGYLATED ARGININE DEIMINASE IN PATIENTS WITH MALIGNANT PLEURAL MESOTHELIOMA . JOURNAL OF THORACIC ONCOLOGY vol. 8 , S308 - S308 .
Gadaleta E, Cutts RJ, Sangaralingam A, Lemoine NR, Chelala C ( 2013 ) . An Integrated Systems Approach to the Study of Pancreatic Cancer . Systems Biology in Cancer Research and Drug Discovery ,
Dayem Ullah AZ, Lemoine NR, Chelala C ( 2013 ) . A practical guide for the functional annotation of genetic variations using SNPnexus . Brief Bioinform vol. 14 , ( 4 ) 437 - 447 .
Chard LS, Maniati E, Wang P, Hughes J, Wang J, Denes B, Fodor I, Hagemann T et al. ( 2013 ) . A Vaccinia Virus Armed with Interleukin-10 That Dampens Host Immunity to the Vctor but Not to Tumor Is a Promising Therapeutic Agent for Pancreatic Cancer . MOLECULAR THERAPY . vol. 21 , S196 - S196 .
Hughes J, Wang P, Alusi G, Bhakta V, Chu Y, Shi H, McNeish I, McCart A et al. ( 2013 ) . Lister Strain Vaccinia Virus Demonstrates Favourable Anti-Tumor Efficacy and Tumor-Selectivity Compared to Western Reserve Strain . MOLECULAR THERAPY . vol. 21 , S216 - S216 .
Coleman S, Chioni A-M, Ghallab M, Lemoine N, Grose RP, Kocher H ( 2013 ) . 538 Nuclear Translocation of FGFR1 and FGF2 in Pancreatic Stellate Cells Is Necessary for Pancreatic Cancer Cell Invasion . Gastroenterology vol. 144 , ( 5 ) s - 98 .
Coleman S, Chioni A-M, Ghallab M, Lemoine N, Grose RP, Kocher H ( 2013 ) . Nuclear Translocation of FGFR1 and FGF2 in Pancreatic Stellate Cells Is Necessary for Pancreatic Cancer Cell Invasion . GASTROENTEROLOGY . vol. 144 , S98 - S98 .
Barry S, Chelala C, Lines K, Sunamura M, Wang A, Marelli-Berg FM, Brennan C, Lemoine NR et al. ( 2013 ) . S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells . Clin Exp Metastasis vol. 30 , ( 3 ) 251 - 264 .
Hiley CT, Chard LS, Gangeswaran R, Tysome JR, Briat A, Lemoine NR, Wang Y ( 2013 ) . Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway . J Virol vol. 87 , ( 5 ) 2781 - 2790 .
Crnogorac-Jurcevic T, Chelala C, Barry S, Harada T, Bhakta V, Lattimore S, Jurcevic S, Bronner M et al. ( 2013 ) . Molecular analysis of precursor lesions in familial pancreatic cancer . PLoS One vol. 8 , ( 1 )
Coleman SJ, Chioni A-M, Ghallab M, Anderson RK, Lemoine NR, Grose RP, Kocher HM ( 2013 ) . Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells is necessary for pancreatic cancer cell invasion . Pancreatology vol. 13 , ( 1 ) e10 - e11 .
Ahmed J, Yuan M, Alusi G, Lemoine NR, Wang Y ( 2013 ) . The Lister Strain of Vaccinia Virus as an Anticancer Therapeutic Agent . Gene Therapy of Cancer: Translational Approaches from Preclinical Studies to Clinical Implementation: Third Edition ,
Tysome JR, Lemoine NR, Wang Y ( 2013 ) . Update on oncolytic viral therapy - targeting angiogenesis . Onco Targets Ther vol. 6 , 1031 - 1040 .
Tysome JR, Li X, Wang S, Wang P, Gao D, Du P, Chen D, Gangeswaran R et al. ( 2012 ) . A novel therapeutic regimen to eradicate established solid tumors with an effective induction of tumor-specific immunity . Clin Cancer Res vol. 18 , ( 24 ) 6679 - 6689 .
Adam V, Ekblad M, Sweeney K, Müller H, Busch KH, Johnsen CT, Kang NR, Lemoine NR et al. ( 2012 ) . Synergistic and Selective Cancer Cell Killing Mediated by the Oncolytic Adenoviral Mutant AdΔΔ and Dietary Phytochemicals in Prostate Cancer Models . Hum Gene Ther vol. 23 , ( 9 ) 1003 - 1015 .
Hiley CT, Chard L, Tysome J, Briat A, Lemoine NR, Wang Y ( 2012 ) . Abstract A37: Increased efficacy of oncolytic vaccinia virus, an emerging therapy for pancreatic adenocarcinoma, due to intratumoral hypoxia and vascular endothelial growth factor A . a37 - a37 .
Delage B, Luong P, Maharaj L, O'Riain C, Syed N, Crook T, Hatzimichael E, Papoudou-Bai A et al. ( 2012 ) . Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis . Cell Death Dis vol. 3 ,
Cutts RJ, Dayem Ullah AZ, Sangaralingam A, Gadaleta E, Lemoine NR, Chelala C ( 2012 ) . O-miner: an integrative platform for automated analysis and mining of -omics data . Nucleic Acids Res vol. 40 , ( Web Server issue ) W560 - W568 .
Dayem Ullah AZ, Lemoine NR, Chelala C ( 2012 ) . SNPnexus: a web server for functional annotation of novel and publicly known genetic variants (2012 update) . Nucleic Acids Res vol. 40 , ( Web Server issue ) W65 - W70 .
Wang P, Jiang G, Chard L, Wang J, Gao D, Cao H, Lemoine NR, Wang Y ( 2012 ) . A Rationally Designed Oncolytic Adenovirus, Ad-TD-IL-12, Cures Pancreatic Cancer in the Immunocompetent Syrian Hamster . MOLECULAR THERAPY . vol. 20 , S131 - S131 .
Sweeney KG, Cheong SC, Lemoine NR, Hallden G ( 2012 ) . Abstract 2712: A non-replicating adenovirus expressing Hey1 is cytotoxic to prostate cancer cells . 2712 - 2712 .
Maya-Pineda HR, Miranda-Rota E, Lemoine NR, Halldén G ( 2012 ) . Abstract 2713: Adenovirus E1A binding to p300 is essential for synergistic cell killing in combination with chemotherapeutic drugs in prostate cancer cells . 2713 - 2713 .
Wong HH, Jiang G, Gangeswaran R, Wang P, Wang J, Yuan M, Wang H, Bhakta V et al. ( 2012 ) . Modification of the early gene enhancer-promoter improves the oncolytic potency of adenovirus 11 . Mol Ther vol. 20 , ( 2 ) 306 - 316 .
Miranda E, Maya Pineda H, Öberg D, Cherubini G, Garate Z, Lemoine NR, Halldén G ( 2012 ) . Adenovirus-mediated sensitization to the cytotoxic drugs docetaxel and mitoxantrone is dependent on regulatory domains in the E1ACR1 gene-region . PLoS One vol. 7 , ( 10 )
Ferguson MS, Lemoine NR, Wang Y ( 2012 ) . Systemic delivery of oncolytic viruses: hopes and hurdles . Adv Virol vol. 2012 ,
Cherubini G, Kallin C, Mozetic A, Hammaren-Busch K, Müller H, Lemoine NR, Halldén G ( 2011 ) . The oncolytic adenovirus AdΔΔ enhances selective cancer cell killing in combination with DNA-damaging drugs in pancreatic cancer models . Gene Ther vol. 18 , ( 12 ) 1157 - 1165 .
Dumartin L, Whiteman HJ, Weeks ME, Hariharan D, Dmitrovic B, Iacobuzio-Donahue CA, Brentnall TA, Bronner MP et al. ( 2011 ) . AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D . Cancer Res vol. 71 , ( 22 ) 7091 - 7102 .
Gadaleta E, Cutts RJ, Kelly GP, Crnogorac-Jurcevic T, Kocher HM, Lemoine NR, Chelala C ( 2011 ) . A global insight into a cancer transcriptional space using pancreatic data: importance, findings and flaws . Nucleic Acids Res vol. 39 , ( 18 ) 7900 - 7907 .
Bhattacharyya M, Francis J, Eddouadi A, Lemoine NR, Halldén G ( 2011 ) . An oncolytic adenovirus defective in pRb-binding (dl922-947) can efficiently eliminate pancreatic cancer cells and tumors in vivo in combination with 5-FU or gemcitabine . Cancer Gene Ther vol. 18 , ( 10 ) 734 - 743 .
Tysome JR, Wang P, Alusi G, Briat A, Gangeswaran R, Wang J, Bhakta V, Fodor I et al. ( 2011 ) . Lister vaccine strain of vaccinia virus armed with the endostatin-angiostatin fusion gene: an oncolytic virus superior to dl1520 (ONYX-015) for human head and neck cancer . Hum Gene Ther vol. 22 , ( 9 ) 1101 - 1108 .
Gadaleta E, Lemoine NR, Chelala C ( 2011 ) . Online resources of cancer data: barriers, benefits and lessons . Brief Bioinform vol. 12 , ( 1 ) 52 - 63 .
Cutts RJ, Gadaleta E, Hahn SA, Crnogorac-Jurcevic T, Lemoine NR, Chelala C ( 2011 ) . The Pancreatic Expression database: 2011 update . Nucleic Acids Res vol. 39 , ( Database issue ) D1023 - D1028 .
Cutts RJ, Gadaleta E, Lemoine NR, Chelala C ( 2011 ) . Using BioMart as a framework to manage and query pancreatic cancer data . Database (Oxford) vol. 2011 ,
Dumartin L, Whiteman HJ, Weeks ME, Timms JF, Brentnall TA, Bronner MP, Brennan C, Lemoine NR et al. ( 2010 ) . AGR2 Regulates the Invasion of Pancreatic Cancer Cells Through Cathepsins B and D . PANCREAS vol. 39 , ( 8 ) 1318 - 1319 .
Jiang G, Cao F, Ren G, Gao D, Bhakta V, Zhang Y, Cao H, Dong Z et al. ( 2010 ) . PRSS3 promotes tumour growth and metastasis of human pancreatic cancer . Gut vol. 59 , ( 11 ) 1535 - 1544 .
Sweeney K, Cheong SC, Lemoine N, Hallden G ( 2010 ) . A non-replicating adenovirus expressing Hey1 is cytotoxic to prostate cancer cells . HUMAN GENE THERAPY . vol. 21 , 1398 - 1398 .
Ekblad M, Oberg D, Lemoine N, Hallden G ( 2010 ) . Development of an oncolytic adenovirus expressing the prodrug-converting enzyme CD/UPRT (Ad Delta Delta CU) . HUMAN GENE THERAPY . vol. 21 , 1473 - 1473 .
Radhakrishnan S, Miranda E, Ekblad M, Holford A, Pizarro MT, Lemoine NR, Halldén G ( 2010 ) . Efficacy of oncolytic mutants targeting pRb and p53 pathways is synergistically enhanced when combined with cytotoxic drugs in prostate cancer cells and tumor xenografts . Hum Gene Ther vol. 21 , ( 10 ) 1311 - 1325 .
Cherubini G, Kalllin C, Mozetic A, Hammaren-Busch K, Muller H, Lemoine N, Hallden G ( 2010 ) . Investigating a new potent and selective oncolytic adenovirus (Ad Delta Delta) in combination with chemotherapy . HUMAN GENE THERAPY . vol. 21 , 1473 - 1474 .
Mao XY, Yu YW, Boyd LK, Ren GP, Lin DM, Chaplin T, Kudahetti SC, Stankiewicz E et al. ( 2010 ) . Distinct Genomic Alterations in Prostate Cancers in Chinese and Western Populations Suggest Alternative Pathways of Prostate Carcinogenesis . CANCER RES vol. 70 , ( 13 ) 5207 - 5212 .
Wong HH, Lemoine NR ( 2010 ) . Novel therapies for pancreatic cancer: setbacks and progress . Future Oncol vol. 6 , ( 7 ) 1061 - 1064 .
Delage B, Fennell DA, Nicholson L, McNeish I, Lemoine NR, Crook T, Szlosarek PW ( 2010 ) . Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer . Int J Cancer vol. 126 , ( 12 ) 2762 - 2772 .
Sziosarek PW, Delage B, O'Riain C, Hatzimichael E, Crook T, Calaminici M, Gribben JG, Lemoine N et al. ( 2010 ) . Effect of inactivation of argininosuccinate synthetase on sensitivity of lymphomas to caspase-dependent apoptosis following treatment with arginine deiminase . JOURNAL OF CLINICAL ONCOLOGY vol. 28 , ( 15 )
Hiley CT, Yuan M, Lemoine NR, Wang Y ( 2010 ) . Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours . Gene Ther vol. 17 , ( 2 ) 281 - 287 .
Oberg D, Yanover E, Adam V, Sweeney K, Costas C, Lemoine NR, Halldén G ( 2010 ) . Improved potency and selectivity of an oncolytic E1ACR2 and E1B19K deleted adenoviral mutant in prostate and pancreatic cancers . Clin Cancer Res vol. 16 , ( 2 ) 541 - 553 .
Wong HH, Lemoine NR, Wang Y ( 2010 ) . Oncolytic viruses for cancer therapy: overcoming the obstacles . Viruses vol. 2 , ( 1 ) 78 - 106 .
Tysome JR, Lemoine NR, Wang YH ( 2009 ) . Combination of anti-angiogenic therapy and virotherapy: Arming oncolytic viruses with anti-angiogenic genes . CURR OPIN MOL THER vol. 11 , ( 6 ) 664 - 669 .
Pardo OE, Latigo J, Jeffery RE, Nye E, Poulsom R, Spencer-Dene B, Lemoine NR, Stamp GW et al. ( 2009 ) . The fibroblast growth factor receptor inhibitor PD173074 blocks small cell lung cancer growth in vitro and in vivo . Cancer Res vol. 69 , ( 22 ) 8645 - 8651 .
Peerlinck I, Merron A, Baril P, Conchon S, Martin-Duque P, Hindorf C, Burnet J, Quintanilla M et al. ( 2009 ) . Targeted radionuclide therapy using a Wnt-targeted replicating adenovirus encoding the Na/I symporter . Clin Cancer Res vol. 15 , ( 21 ) 6595 - 6601 .
Tysome JR, Briat A, Alusi G, Cao F, Gao D, Yu J, Wang P, Yang S et al. ( 2009 ) . Lister strain of vaccinia virus armed with endostatin-angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancer . Gene Ther vol. 16 , ( 10 ) 1223 - 1233 .
Seckl MJ, Pardo OE, Aboagye EO, Latigo J, Stamp G, Lemoine N, Spencer-Dean B ( 2009 ) . The FGF receptor (FGFR) inhibitor PD0173074 blocks SCLC growth in vitro and in vivo . J THORAC ONCOL vol. 4 , ( 9 ) S385 - S385 .
Wong HH, Lemoine NR ( 2009 ) . Pancreatic cancer: molecular pathogenesis and new therapeutic targets (vol 6, pg 412, 2009) . NAT REV GASTRO HEPAT vol. 6 , ( 8 ) 440 - 440 .
Wong HH, Lemoine NR ( 2009 ) . Pancreatic cancer: molecular pathogenesis and new therapeutic targets . Nat Rev Gastroenterol Hepatol vol. 6 , ( 7 ) 412 - 422 .
Wang Y, Gangeswaran R, Zhao X, Wang P, Tysome J, Bhakta V, Yuan M, Chikkanna-Gowda CP et al. ( 2009 ) . CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells . J Clin Invest vol. 119 , ( 6 ) 1604 - 1615 .
Wong HH, Gangeswaran R, Francis J, Lemoine NR, Wang Y ( 2009 ) . Adenovirus 11 is an Alternative Oncolytic Virus Targeting Adenovirus 5-Insensitive Cancer and Shows Distinct E1A Gene Transcriptional Activity . MOLECULAR THERAPY . vol. 17 , S235 - S236 .
Adam V, Oberg D, Lemoine N, Hallden G ( 2009 ) . Prostate Cancer Targeting by Replication-Selective Adenoviral Mutants: Combination Treatments with Phytochemical Drugs . MOLECULAR THERAPY . vol. 17 , S320 - S320 .
Tysome JR, Briat A, Hiley C, Gangeswaran R, Chikkanna-Gowda CP, Bhakta V, Alusi G, Trivedi K et al. ( 2009 ) . Systemic Delivery of Lister Strain Vaccinia Virus to Tumors Is Facilitated by the Depletion of Macrophages in Immuno-Competent Mice . MOLECULAR THERAPY . vol. 17 , S247 - S247 .
Leitner S, Sweeney K, Oberg D, Davies D, Miranda E, Lemoine NR, Halldén G ( 2009 ) . Oncolytic adenoviral mutants with E1B19K gene deletions enhance gemcitabine-induced apoptosis in pancreatic carcinoma cells and anti-tumor efficacy in vivo . Clin Cancer Res vol. 15 , ( 5 ) 1730 - 1740 .
Chelala C, Khan A, Lemoine NR ( 2009 ) . SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms . Bioinformatics vol. 25 , ( 5 ) 655 - 661 .
Marinov M, Ziogas A, Pardo OE, Tan LT, Dhillon T, Mauri FA, Lane HA, Lemoine NR et al. ( 2009 ) . AKT/mTOR pathway activation and BCL-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001 . Clin Cancer Res vol. 15 , ( 4 ) 1277 - 1287 .
Chelala C, Lemoine NR, Hahn SA, Crnogorac-Jurcevic T ( 2009 ) . A web-based platform for mining pancreatic expression datasets . Pancreatology vol. 9 , ( 4 ) 340 - 343 .
Harada T, Chelala C, Crnogorac-Jurcevic T, Lemoine NR ( 2009 ) . Genome-wide analysis of pancreatic cancer using microarray-based techniques . Pancreatology vol. 9 , ( 1-2 ) 13 - 24 .
Tysome JR, Briat A, Alusi G, Cao F, Yu J, Wang P, Yang S, Dong Z et al. ( 2009 ) . Lister strain of vaccinia virus armed with endostatin–angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancerVaccine strain of vaccinia virus for cancer therapy . Gene Therapy vol. 16 , ( 10 ) 1223 - 1233 .
Antonello D, Gobbo S, Corbo V, Sipos B, Lemoine NR, Scarpa A ( 2009 ) . Update on the molecular pathogenesis of pancreatic tumors other than common ductal adenocarcinoma . Pancreatology vol. 9 , ( 1-2 ) 25 - 33 .
Yuan M, Tomlinson V, Lara R, Holliday D, Chelala C, Harada T, Gangeswaran R, Manson-Bishop C et al. ( 2008 ) . Yes-associated protein (YAP) functions as a tumor suppressor in breast . Cell Death Differ vol. 15 , ( 11 ) 1752 - 1759 .
Adam V, Lemoine N, Hallden G ( 2008 ) . Prostate cancer targeting by replication-selective adenoviral mutants: combination treatments with phytochemical drugs . HUMAN GENE THERAPY . vol. 19 , 1165 - 1165 .
Peerlinck I, Amini-Nik S, Phillips RK, Iggo R, Lemoine NR, Tejpar S, Vassaux G ( 2008 ) . Therapeutic potential of replication-selective oncolytic adenoviruses on cells from familial and sporadic desmoid tumors . Clin Cancer Res vol. 14 , ( 19 ) 6187 - 6192 .
Tysome JR, Alusi G, Lemoine N, Wang Y ( 2008 ) . Oncolytic Vaccinia Virus Gene Therapy for HNSCC . Otolaryngology vol. 139 , ( 2 ) p92 - p93 .
Weeks ME, Hariharan D, Petronijevic L, Radon TR, Whiteman HJ, Kocher HM, Timms JF, Lemoine NR et al. ( 2008 ) . Analysis of the urine proteome in patients with pancreatic ductal adenocarcinoma . PROTEOM CLIN APPL vol. 2 , ( 7-8 ) 1047 - 1057 .
Montiel-Equihua CA, Martín-Duque P, de la Vieja A, Quintanilla M, Burnet J, Vassaux G, Lemoine NR ( 2008 ) . Targeting sodium/iodide symporter gene expression for estrogen-regulated imaging and therapy in breast cancer . Cancer Gene Ther vol. 15 , ( 7 ) 465 - 473 .
Lemoine NR ( 2008 ) . The clinician-scientist: a rare breed under threat in a hostile environment . Dis Model Mech vol. 1 , ( 1 ) 12 - 14 .
Tysome J, Alusi G, Fodor I, Lemoine N, Wang Y ( 2008 ) . Oncolytic vaccinia virus armed with the endostatin‐angiostatin fusion protein; a novel therapy for head and neck cancer . Clinical Otolaryngology vol. 33 , ( 3 ) 300 - 300 .
Baird SK, Aerts JL, Eddaoudi A, Lockley M, Lemoine NR, McNeish IA ( 2008 ) . Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer . Oncogene vol. 27 , ( 22 ) 3081 - 3090 .
Baird SK, Ingemarsdotter CK, Eddaoudi A, Lockley M, Lemoine NR, McNeish IA ( 2008 ) . Oncolytic adenoviral mutants define a novel mode of programmed cell death in ovarian cancer . HUMAN GENE THERAPY . vol. 19 , 399 - 399 .
Adam VS, Lemoine N, Hallden G ( 2008 ) . Prostate cancer targeting by replication-selective adenoviral mutants: Combination treatments with phytochemical drugs . HUMAN GENE THERAPY . vol. 19 , 419 - 419 .
Harada T, Chelala C, Bhakta V, Chaplin T, Caulee K, Baril P, Young BD, Lemoine NR ( 2008 ) . Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays . Oncogene vol. 27 , ( 13 ) 1951 - 1960 .
Wong HH, Lemoine NR ( 2008 ) . Biological approaches to therapy of pancreatic cancer . Pancreatology vol. 8 , ( 4-5 ) 431 - 461 .
Cheong SC, Wang Y, Meng J-H, Hill R, Sweeney K, Kirn D, Lemoine NR, Halldén G ( 2008 ) . E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models . Cancer Gene Ther vol. 15 , ( 1 ) 40 - 50 .
Danovi SA, Wong HH, Lemoine NR ( 2008 ) . Targeted therapies for pancreatic cancer . Br Med Bull vol. 87 , 97 - 130 .
Marinov M, Ziogas A, Pardo OE, Tan LT, Lane HA, Lemoine NR, Zangemeister-Wittke U, Seckl MJ et al. ( 2007 ) . Akt/mTOR pathway activation and Bcl-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001 (Everolimus) . MOL CANCER THER vol. 6 , ( 12 ) 3409S - 3409S .
Aiuti A, Bachoud-Levi AC, Blesch A, Brenner MK, Cattaneo F, Chiocca EA, Gao G, High KA et al. ( 2007 ) . Progress and prospects: gene therapy clinical trials (part 2) (vol 14, pg 1555, 2007) . GENE THER vol. 14 , ( 24 ) 1754 - 1754 .
Chelala C, Hahn SA, Whiteman HJ, Barry S, Hariharan D, Radon TP, Lemoine NR, Crnogorac-Jurcevic T ( 2007 ) . Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets . BMC GENOMICS vol. 8 , Article 439 ,
Aiuti A, Bachoud-Lévi AC, Blesch A, Brenner MK, Cattaneo F, Chiocca EA, Gao G, High KA et al. ( 2007 ) . Progress and prospects: gene therapy clinical trials (part 2) . Gene Ther vol. 14 , ( 22 ) 1555 - 1563 .
Bond JA, Gescher AJ, Verschoyle RD, Lemoine NR, Errington R, Wiltshire M, Smith PJ, Wynford-Thomas D ( 2007 ) . Cytotoxic action of phorbol esters on human pancreatic cancer cells . INT J CANCER vol. 121 , ( 7 ) 1445 - 1454 .
Cheong SC, Lemoine N, Hallden G ( 2007 ) . Inhibition of androgen receptor signaling pathways in prostate cancer cells by adenoviral vectors expressing Hey1 . HUMAN GENE THERAPY . vol. 18 , 1004 - 1004 .
Whiteman HJ, Weeks ME, Dowen SE, Barry S, Timms JF, Lemoine NR, Crnogorac-Jurcevic T ( 2007 ) . The role of S100P in the invasion of pancreatic cancer cells is mediated through cytoskeletal changes and regulation of cathepsin D . Cancer Res vol. 67 , ( 18 ) 8633 - 8642 .
Mahon PC, Baril P, Bhakta V, Chelala C, Caulee K, Harada T, Lemoine NR ( 2007 ) . S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer . Cancer Res vol. 67 , ( 14 ) 6786 - 6795 .
Lopes RB, Gangeswaran R, McNeish IA, Wang YH, Lemoine NR ( 2007 ) . Expression of the IAP protein family is dysregulated in pancreatic cancer cells and is important for resistance to chemotherapy . INT J CANCER vol. 120 , ( 11 ) 2344 - 2352 .
Radhakrishnan S, Hallden G, Chinegwundoh F, Lemoine N ( 2007 ) . Synergistic enhancement of prostate cancer cell death by combination therapy of adenovirus and chemotherapy . BJU INTERNATIONAL . vol. 99 , 28 - 28 .
Sheikh AA, Vimalachandran D, Thompson CC, Jenkins RE, Nedjadi T, Shekouh A, Campbell F, Dodson A et al. ( 2007 ) . The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells . PROTEOMICS . vol. 7 , 1929 - 1940 .
Pandha H, Rigg A, John J, Lemoine N ( 2007 ) . Loss of expression of antigen-presenting molecules in human pancreatic cancer and pancreatic cancer cell lines . CLIN EXP IMMUNOL vol. 148 , ( 1 ) 127 - 135 .
Radhakrishnan S, Hallden GK, Chinegwundoh F, Lemoine N ( 2007 ) . Synergistic enhancement of cell death by combination therapy with adenovirus and chemotherapy . JOURNAL OF UROLOGY . vol. 177 , 182 - 183 .
Baril P, Gangeswaran R, Mahon PC, Caulee K, Kocher HM, Harada T, Zhu M, Kalthoff H et al. ( 2007 ) . Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway . Oncogene vol. 26 , ( 14 ) 2082 - 2094 .
Neesse A, Gangeswaran R, Luettges J, Feakins R, Weeks ME, Lemoine NR, Crnogorac-Jurcevic T ( 2007 ) . Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells . Oncogene vol. 26 , ( 11 ) 1533 - 1545 .
Harada T, Baril P, Gangeswaran R, Kelly G, Chelala C, Bhakta V, Caulee K, Mahon PC et al. ( 2007 ) . Identification of genetic alterations in pancreatic cancer by the combined use of tissue microdissection and array-based comparative genomic hybridisation . Br J Cancer vol. 96 , ( 2 ) 373 - 382 .
Thompson CC, Ashcroft FJ, Patel S, Saraga G, Vimalachandran D, Prime W, Campbell F, Dodson A et al. ( 2007 ) . Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility . GUT vol. 56 , ( 1 ) 95 - 106 .
Neesse A, Gangeswaran R, Luettges J, Feakins R, Weeks ME, Lemoine NR, Crnogorac-Jurcevic T ( 2006 ) . Sperm associated antigen 1 (spag1) is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells . PANCREAS vol. 33 , ( 4 ) 485 - 486 .
Vimalachandran D, Sheikh A, Tweedle E, Khattak I, Thompson CC, Jenkins RE, Nedjadi T, Shekouh A et al. ( 2006 ) . The expression of S100A8 in tumour-associated monocytes is directly associated with the Smad4 status of pancreatic cancer cells . PANCREAS vol. 33 , ( 4 ) 506 - 506 .
Leyton J, Lockley M, Aerts JL, Baird SK, Aboagye EO, Lemoine NR, McNeish IA ( 2006 ) . Quantifying the activity of adenoviral E1A CR2 deletion mutants using renilla luciferase bioluminescence and 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography imaging . Cancer Res vol. 66 , ( 18 ) 9178 - 9185 .
Capurso G, Lattimore S, Crnogorac-Jurcevic T, Panzuto F, Milione M, Bhakta V, Campanini N, Swift SM et al. ( 2006 ) . Gene expression profiles of progressive pancreatic endocrine tumours and their liver metastases reveal potential novel markers and therapeutic targets . ENDOCR-RELAT CANCER vol. 13 , ( 2 ) 541 - 558 .
Khan SA, Taylor-Robinson SD, Carmichael PL, Habib N, Lemoine NR, Thomas HC ( 2006 ) . Analysis of p53 mutations for a mutational signature in human intrahepatic cholangiocarcinoma . Int J Oncol vol. 28 , ( 5 ) 1269 - 1277 .
Martin-Duque P, Quintanilla M, McNeish I, Lopes R, Romero J, Romero D, Lemoine NR, Cajal SRY et al. ( 2006 ) . Caspase-1 as a radio- and chemo-sensitiser in vitro and in vivo . INT J MOL MED vol. 17 , ( 5 ) 841 - 847 .
Bhattacharrya M, Lemoine NR ( 2006 ) . Gene therapy developments for pancreatic cancer . BEST PRACT RES CL GA vol. 20 , ( 2 ) 285 - 298 .
Chernajovsky Y, Layward L, Lemoine N ( 2006 ) . Controversy - Fighting cancer with oncolytic viruses . BRIT MED J vol. 332 , ( 7534 ) 170 - 172 .
Chernajovsky Y, Layward L, Lemoine N ( 2006 ) . Fighting cancer with oncolytic viruses . BMJ vol. 332 , ( 7534 ) 170 - 172 .
Lockley M, Fernandez M, Wang Y, Li NF, Conroy S, Lemoine N, McNeish I ( 2006 ) . Activity of the adenoviral E1A deletion mutant dl922-947 in ovarian cancer: comparison with E1A wild-type viruses, bioluminescence monitoring, and intraperitoneal delivery in icodextrin . Cancer Res vol. 66 , ( 2 ) 989 - 998 .
Vassaux G, Nitcheu J, Jezzard S, Lemoine NR ( 2006 ) . Bacterial gene therapy strategies . J Pathol vol. 208 , ( 2 ) 290 - 298 .
Martin-Duque P, Quintanilla M, McNeish I, Lopes R, Romero J, Romero D, Lemoine NR, Cajal SRY et al. ( 2005 ) . Radio- and chemo-sensitization by caspase-1 in vitro and in vivo . CLINICAL CANCER RESEARCH . vol. 11 , 8996S - 8996S .
Arencibia JM, Del Rio M, Bonnin A, Lopes R, Lemoine NR, López-Barahona M ( 2005 ) . Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation . Int J Oncol vol. 27 , ( 6 ) 1617 - 1623 .
Crnogorac-Jurcevic T, Gangeswaran R, Bhakta V, Capurso G, Lattimore S, Akada M, Sunamura M, Prime W et al. ( 2005 ) . Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma . Gastroenterology vol. 129 , ( 5 ) 1454 - 1463 .
Smith PG, Oakley F, Fernandez M, Mann DA, Lemoine NR, Whitehouse A ( 2005 ) . Herpesvirus saimiri-based vector biodistribution using noninvasive optical imaging . Gene Ther vol. 12 , ( 19 ) 1465 - 1476 .
Vimalachandran CD, Watson R, Thompson CC, Greenhalf W, Yan L, Prime W, Campbell F, Dodson A et al. ( 2005 ) . High nuclear A100A6 (calcyclin) is significantly associated with poor survival in pancreatic cancer patients . BRITISH JOURNAL OF SURGERY . vol. 92 , 1313 - 1314 .
Liu T-C, Wang Y, Hallden G, Brooks G, Francis J, Lemoine NR, Kirn D ( 2005 ) . Functional interactions of antiapoptotic proteins and tumor necrosis factor in the context of a replication-competent adenovirus . Gene Ther vol. 12 , ( 17 ) 1333 - 1346 .
Lemoine NR ( 2005 ) . Silencing RNA: a novel treatment for pancreatic cancer? . GUT vol. 54 , ( 9 ) 1215 - 1216 .
Lopes R, Castro I, Pontes P, Candeias J, Lemoine NR, Sambade C ( 2005 ) . Expression profile of survivin in acute leukaemias: the importance of differential splicing . Leukemia vol. 19 , ( 7 ) 1284 - 1286 .
Petralia GA, Lemoine NR, Kakkar AK ( 2005 ) . Mechanisms of disease: the impact of antithrombotic therapy in cancer patients . Nat Clin Pract Oncol vol. 2 , ( 7 ) 356 - 363 .
Buluwela L, Pike J, Mazhar D, Kamalati T, Hart SM, Al-Jehani R, Yahaya H, Patel N et al. ( 2005 ) . Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-alpha and the transcriptional repressor PLZF (vol 12, pg 452, 2005) . GENE THER vol. 12 , ( 10 ) 862 - 862 .
Vimalachandran D, Greenhalf W, Thompson C, Luttges J, Prime W, Campbell F, Dodson A, Watson R et al. ( 2005 ) . High nuclear S100A6 (Calcyclin) is significantly associated with poor survival in pancreatic cancer patients . CANCER RES vol. 65 , ( 8 ) 3218 - 3225 .
Akada M, Crnogorac-Jurcevic T, Lattimore S, Mahon P, Lopes R, Sunamura M, Matsuno S, Lemoine NR ( 2005 ) . Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer . CLIN CANCER RES vol. 11 , ( 8 ) 3094 - 3101 .
Lemoine NR ( 2005 ) . Antithrombotic therapy in cancer . J Clin Oncol vol. 23 , ( 10 ) 2119 - 2120 .
Capurso G, Lattimore S, Crnogorac-Jurcevic T, Panzuto F, Milione M, Bhakta V, Bordi C, Lemoine NR et al. ( 2005 ) . Gene expression profiles of non-functioning primary and metastatic pancreatic endocrine tumours (pets) reveal potential new markers and targets for therapy . GASTROENTEROLOGY . vol. 128 , A483 - A483 .
Buluwela L, Pike J, Mazhar D, Kamalati T, Hart SM, Al-Jehani R, Yahaya H, Patel N et al. ( 2005 ) . Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-alpha and the transcriptional repressor PLZF (vol 12, pg 452, 2005) . GENE THER vol. 12 , ( 6 ) 552 - 552 .
Buluwela L, Pike J, Mazhar D, Kamalati T, Hart SM, Al-Jehani R, Yahaya H, Patel N et al. ( 2005 ) . Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-alpha and the transcriptional repressor PLZF . Gene Ther vol. 12 , ( 5 ) 452 - 460 .
Wang Y, Xue S-A, Hallden G, Francis J, Yuan M, Griffin BE, Lemoine NR ( 2005 ) . Virus-associated RNA I-deleted adenovirus, a potential oncolytic agent targeting EBV-associated tumors . Cancer Res vol. 65 , ( 4 ) 1523 - 1531 .
Missiaglia E, Donadelli M, Palmieri M, Crnogorac-Jurcevic T, Scarpa A, Lemoine NR ( 2005 ) . Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatment is associated with activation of the interferon signalling pathway . Oncogene vol. 24 , ( 1 ) 199 - 211 .
Wang Y, Thorne S, Hannock J, Francis J, Au T, Reid T, Lemoine N, Kirn D et al. ( 2005 ) . A novel assay to assess primary human cancer infectibility by replication-selective oncolytic adenoviruses . Clin Cancer Res vol. 11 , ( 1 ) 351 - 360 .
Stoll V, Calleja V, Vassaux G, Downward J, Lemoine NR ( 2005 ) . Dominant negative inhibitors of signalling through the phosphoinositol 3-kinase pathway for gene therapy of pancreatic cancer . Gut vol. 54 , ( 1 ) 109 - 116 .
Dowen SE, Crnogorac-Jurcevic T, Gangeswaran R, Hansen M, Eloranta JJ, Bhakta V, Brentnall TA, Luttges J et al. ( 2005 ) . Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer . AM J PATHOL vol. 166 , ( 1 ) 81 - 92 .
Capurso G, Crnogorac-Jurcevic T, Milione M, Panzuto F, Campanini N, Dowen SE, Di Florio A, Sette C et al. ( 2005 ) . Peanut-like 1 (septin 5) gene expression in normal and neoplastic human endocrine pancreas . Neuroendocrinology vol. 81 , ( 5 ) 311 - 321 .
McNeish IA, Lopes R, Bell SJ, McKay TR, Fernandez M, Lockley M, Wheatley SP, Lemoine NR ( 2005 ) . Survivin interacts with Smac/DIABLO in ovarian carcinoma cells but is redundant in Smac-mediated apoptosis . Exp Cell Res vol. 302 , ( 1 ) 69 - 82 .
Savage P, Cowburn P, Clemens D, Hurley T, Laguda B, Martin-Duque P, Vassaux G, Lemoine NR ( 2004 ) . Suicide gene therapy conversion of ethanol to acetaldehyde mediated by human beta 2 alcohol dehydrogenase . CANCER GENE THER vol. 11 , ( 12 ) 774 - 781 .
Petrovska L, Aspinall RJ, Barber L, Clare S, Simmons CP, Stratford R, Khan SA, Lemoine NR et al. ( 2004 ) . Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene . CELL MICROBIOL vol. 6 , ( 11 ) 1071 - 1084 .
Missiaglia E, Blaveri E, Terris B, Wang Y-H, Costello E, Neoptolemos JP, Crnogorac-Jurcevic T, Lemoine NR ( 2004 ) . Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis . Int J Cancer vol. 112 , ( 1 ) 100 - 112 .
Pike J, Holmes D, Kamalati T, Davies D, Tolhurst R, Mazhar D, Fishpool S, al-Jehani R et al. ( 2004 ) . Silencing of androgen-regulated genes using a fusion of AR with the PLZF transcriptional repressor . Oncogene vol. 23 , ( 45 ) 7561 - 7570 .
Pardo OE, Lesay A, Arcaro A, Lopes R, Ng BL, Warne PH, McNeish IA, Tetley TD et al. ( 2004 ) . Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells (vol 23, pg 7600, 2003) . MOL CELL BIOL vol. 24 , ( 15 ) 6887 - 6887 .
Critchley RJ, Jezzard S, Radford KJ, Goussard S, Lemoine NR, Grillot-Courvalin C, Vassaux G ( 2004 ) . Potential therapeutic applications of recombinant, invasive E. coli . Gene Ther vol. 11 , ( 15 ) 1224 - 1233 .
Groot-Wassink T, Aboagye EO, Wang Y, Lemoine NR, Keith WN, Vassaux G ( 2004 ) . Noninvasive imaging of the transcriptional activities of human telomerase promoter fragments in mice . Cancer Res vol. 64 , ( 14 ) 4906 - 4911 .
Leslie J, McFaul C, Earl J, Azadeh B, Prime W, Bartsch D, Harada T, Lemoine N et al. ( 2004 ) . Identification of a familial pancreatic cancer gene by focusing haplotype analysis using LOH in sporadic cancer . BRITISH JOURNAL OF CANCER . vol. 91 , S31 - S31 .
Wang Y, Faux SP, Hallden G, Kirn DH, Houghton CE, Lemoine NR, Patrick G ( 2004 ) . Interleukin-1beta and tumour necrosis factor-alpha promote the transformation of human immortalised mesothelial cells by erionite . Int J Oncol vol. 25 , ( 1 ) 173 - 178 .
Vimalachandran D, Watson R, Shekouh A, Thompson C, Campbell F, Prime W, Crngorac-Jurcevic T, Lemoine N et al. ( 2004 ) . The calcium binding protein s100A6 (calcyclin) as a prognostic indicator in pancreatic cancer . BRITISH JOURNAL OF CANCER . vol. 91 , S32 - S32 .
Liu T-C, Hallden G, Wang Y, Brooks G, Francis J, Lemoine N, Kirn D ( 2004 ) . An E1B-19 kDa gene deletion mutant adenovirus demonstrates tumor necrosis factor-enhanced cancer selectivity and enhanced oncolytic potency . Mol Ther vol. 9 , ( 6 ) 786 - 803 .
Burn J, Lemoine N, O'Toole L ( 2004 ) . Assessing cancer risk . Expert Rev Anticancer Ther vol. 4 Suppl 1 , S13 - S17 .
Kakkar AK, Levine MN, Kadziola Z, Lemoine NR, Low V, Patel HK, Rustin G, Thomas M et al. ( 2004 ) . Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS) . J Clin Oncol vol. 22 , ( 10 ) 1944 - 1948 .
Madhusudan S, Tamir A, Bates N, Flanagan E, Gore ME, Barton DPJ, Harper P, Seckl M et al. ( 2004 ) . A multicenter Phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with recurrent epithelial ovarian cancer overexpressing HER-2/neu oncogene . Clin Cancer Res vol. 10 , ( 9 ) 2986 - 2996 .
Yaohe, Pen H, Jennelle, Gunnel, Shao-an, Grriffin BE, Lemoine NR ( 2004 ) . Anti-CD22 immunolipoplexes enhance transduction of adenovirus in B lymphoma cells independent on adenovirus' receptor but do not enhance the cytotoxicity of oncolytic adenovirus . MOLECULAR THERAPY . vol. 9 , S171 - S172 .
Liu TC, Wang YH, Hallden G, Francis J, Brooks G, Lemoine N, Kirn D ( 2004 ) . Oncolytic adenovirus E1B-19kD deletion and E3B retention results in both enhanced potency and tumor necrosis factor-mediated selectivity . MOLECULAR THERAPY . vol. 9 , S109 - S109 .
Hill RJ, Hallden GK, Wang YH, Francis J, Simpson C, Kirn DH, Lemoine NR ( 2004 ) . The gene expression and function of adenoviral E3-genes in murine tumour cell lines . MOLECULAR THERAPY . vol. 9 , S374 - S375 .
Wang YH, Xue SA, Hallden G, Francis J, Griffin BE, Lemoine NR ( 2004 ) . VAI deleted adenovirus as an oncolytic agent targeting human EBV-associated tumours . MOLECULAR THERAPY . vol. 9 , S230 - S230 .
Lemoine NR, McNeish IA ( 2004 ) . Gene transfer: Bax to the future for cancer therapy . Gut vol. 53 , ( 4 ) 478 - 479 .
Marani M, Hancock D, Lopes R, Tenev T, Downward J, Lemoine NR ( 2004 ) . Role of Bim in the survival pathway induced by Raf in epithelial cells . Oncogene vol. 23 , ( 14 ) 2431 - 2441 .
McNeish IA, Bell SJ, Lemoine NR ( 2004 ) . Gene therapy progress and prospects: cancer gene therapy using tumour suppressor genes . Gene Ther vol. 11 , ( 6 ) 497 - 503 .
Groot-Wassink T, Aboagye EO, Wang Y, Lemoine NR, Reader AJ, Vassaux G ( 2004 ) . Quantitative imaging of Na/I symporter transgene expression using positron emission tomography in the living animal . Mol Ther vol. 9 , ( 3 ) 436 - 442 .
Capurso G, Delle Fave G, Lemoine N ( 2004 ) . Re: Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity . J Natl Cancer Inst vol. 96 , ( 1 )
Brown NL, Lemoine NR ( 2004 ) . Clinical trials with GDEPT: cytosine deaminase and 5-fluorocytosine . Methods Mol Med vol. 90 , 451 - 457 .
Nasir FA, Patel HK, Scully MF, Fareed J, Lemoine NR, Kakkar AK ( 2003 ) . The low molecular weight heparins dalteparin sodium inhibits angiogenesis and induces apoptosis in an experimental tumour model . BLOOD . vol. 102 , 808A - 808A .
Wang Y, Hallden G, Hill R, Anand A, Liu T-C, Francis J, Brooks G, Lemoine N et al. ( 2003 ) . E3 gene manipulations affect oncolytic adenovirus activity in immunocompetent tumor models . Nat Biotechnol vol. 21 , ( 11 ) 1328 - 1335 .
Pardo OE, Lesay A, Arcaro A, Lopes R, Ng BL, Warne PH, McNeish IA, Tetley TD et al. ( 2003 ) . Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells . Mol Cell Biol vol. 23 , ( 21 ) 7600 - 7610 .
Shekouh AR, Thompson CC, Prime W, Campbell F, Hamlett J, Herrington CS, Lemoine NR, Crnogorac-Jurcevic T et al. ( 2003 ) . Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma . Proteomics vol. 3 , ( 10 ) 1988 - 2001 .
Wang Y, Groot-Wassink T, Lemoine NR, Vassaux G ( 2003 ) . Cellular characterization of the tropism of recombinant adenovirus for the adrenal glands . Eur J Clin Invest vol. 33 , ( 9 ) 794 - 798 .
Crnogorac-Jurcevic T, Missiaglia E, Blaveri E, Gangeswaran R, Jones M, Terris B, Costello E, Neoptolemos JP et al. ( 2003 ) . Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent . J Pathol vol. 201 , ( 1 ) 63 - 74 .
Halldén G, Hill R, Wang Y, Anand A, Liu T-C, Lemoine NR, Francis J, Hawkins L et al. ( 2003 ) . Novel immunocompetent murine tumor models for the assessment of replication-competent oncolytic adenovirus efficacy . Mol Ther vol. 8 , ( 3 ) 412 - 424 .
Lemoine NR, Kirby RB ( 2003 ) . UK cash for gene therapy: government pledges support . Gene Ther vol. 10 , ( 17 ) 1405 - 1406 .
Radford KJ, Jackson AM, Wang J-H, Vassaux G, Lemoine NR ( 2003 ) . Recombinant E. coli efficiently delivers antigen and maturation signals to human dendritic cells: presentation of MART1 to CD8+ T cells . Int J Cancer vol. 105 , ( 6 ) 811 - 819 .
Zhu G, Reynolds L, Crnogorac-Jurcevic T, Gillett CE, Dublin EA, Marshall JF, Barnes D, D'Arrigo C et al. ( 2003 ) . Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer . Oncogene vol. 22 , ( 24 ) 3742 - 3748 .
McNeish IA, Bell S, McKay T, Tenev T, Marani M, Lemoine NR ( 2003 ) . Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis via a caspase-9-mediated pathway . Exp Cell Res vol. 286 , ( 2 ) 186 - 198 .
McKay TR, Bell S, Tenev T, Stoll V, Lopes R, Lemoine NR, McNeish IA ( 2003 ) . Procaspase 3 expression in ovarian carcinoma cells increases survivin transcription which can be countered with a dominant-negative mutant, survivin T34A; a combination gene therapy strategy . Oncogene vol. 22 , ( 23 ) 3539 - 3547 .
VAN TRAPPEN P ( 2003 ) . Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer . Oncogene vol. 22 , 3742 - 3748 .
Groot-Wassink T, Barthel H, Lemoine NR, Vassaux G ( 2003 ) . Sodium iodide symporter: a new strategy to target cancer? . Lancet vol. 361 , ( 9372 ) 1905 - 1906 .
Liu TC, Wang YH, Hallden G, Anand A, Lemoine NR, Kirn DH ( 2003 ) . Adenoviral E1B-19kD deletion results in enhanced oncolytic effect and reduced toxicity in an immunocompetent murine tumor . MOLECULAR THERAPY . vol. 7 , S416 - S416 .
Wang YH, Francis J, Griffin BE, Lemoine NLR, Xue SA ( 2003 ) . Cytotoxicity of replication-competent adenovirus to lymphoproliferative disorders correlates with expression of heparan sulfate . MOLECULAR THERAPY . vol. 7 , S359 - S359 .
Hill RJ, Hallden GK, Lemoine NR, Kirn DH ( 2003 ) . In vitro screening of murine carcinoma cell lines for testing of replication-competent oncolytic adenoviruses . MOLECULAR THERAPY . vol. 7 , S362 - S362 .
Aspinali RJ, Clare S, Goulding D, Goldin RD, Lemoine NR, Dougan G ( 2003 ) . Microbiology and cellular pathology of infection with sifA-mutant Salmonella typhimurium . GASTROENTEROLOGY . vol. 124 , A484 - A484 .
Crnogorac-Jurcevic T, Lemoine NR ( 2003 ) . Molecular profiles of pancreatic adenocarcinoma . GUT . vol. 52 , A36 - A36 .
Khan SA, Taylor-Robinson SD, Carmichael PL, Habib N, Lemoine N, Thomas HC ( 2003 ) . Novel p53 mutations but lack of a mutational fingerprint in human intrahepatic cholangiocarcinoma . GUT . vol. 52 , A32 - A32 .
Liu TC, Hallden G, Anand A, Wang YH, Lemoine N, Kirn D ( 2003 ) . Adenovirus E1B-19kD gene deletion enhances oncolytic virus efficacy and selectivity . CANCER GENE THERAPY . vol. 10 , S20 - S20 .
Lemoine NR ( 2002 ) . Risks and benefits of gene therapy for immunodeficiency: a reality check . GENE THER vol. 9 , ( 23 ) 1561 - 1562 .
Kakkar AK, Kadziola Z, Williamson RCN, Levine MN, Low V, Lemoine NR, Fragmin Adv Malignancy Outcome ( 2002 ) . Low molecular weight heparin (LMWH) therapy and survival in advanced cancer . BLOOD . vol. 100 , 148A - 148A .
Radford KJ, Higgins DE, Pasquini S, Cheadle EJ, Carta L, Jackson AM, Lemoine NR, Vassaux G ( 2002 ) . A recombinant E. coli vaccine to promote MHC class I-dependent antigen presentation: application to cancer immunotherapy . GENE THER vol. 9 , ( 21 ) 1455 - 1463 .
Campbell NJH, Lemoine NR, Glorioso JC ( 2002 ) . Information overload? Take the 'Progress and Prospects' cure . Gene Ther vol. 9 , ( 20 )
Groot-Wassink T, Aboagye EO, Glaser M, Lemoine NR, Vassaux G ( 2002 ) . Adenovirus biodistribution and noninvasive imaging of gene expression in vivo by positron emission tomography using human sodium/iodide symporter as reporter gene . Hum Gene Ther vol. 13 , ( 14 ) 1723 - 1735 .
Crnogorac-Jurcevic T, Efthimiou E, Nielsen T, Loader J, Terris B, Stamp G, Baron A, Scarpa A et al. ( 2002 ) . Expression profiling of microdissected pancreatic adenocarcinomas . Oncogene vol. 21 , ( 29 ) 4587 - 4594 .
Harrington K, Alvarez-Vallina L, Crittenden M, Gough M, Chong H, Diaz RM, Vassaux G, Lemoine N et al. ( 2002 ) . Cells as vehicles for cancer gene therapy: The missing link between targeted vectors and systemic delivery? . HUM GENE THER vol. 13 , ( 11 ) 1263 - 1280 .
McNeish IA, Bell S, McKay T, Tenev T, Stoll V, Lemoine NR ( 2002 ) . Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis predominantly via a caspase-9-mediated pathway and enhances sensitivity to cisplatin and paclitaxel . BRIT J CANCER vol. 86 , S20 - S21 .
Marani M, Tenev T, Hancock D, Downward J, Lemoine NR ( 2002 ) . Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis . Mol Cell Biol vol. 22 , ( 11 ) 3577 - 3589 .
Tagawa T, Manvell M, Brown N, Keller M, Perouzel E, Murray KD, Harbottle RP, Tecle M et al. ( 2002 ) . Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide mu (mu) and plasmid DNA . GENE THER vol. 9 , ( 9 ) 564 - 576 .
Terris B, Blaveri E, Crnogorac-Jurcevic T, Jones M, Missiaglia E, Ruszniewski P, Sauvanet A, Lemoine NR ( 2002 ) . Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas . AM J PATHOL vol. 160 , ( 5 ) 1745 - 1754 .
Lemoine NR ( 2002 ) . The power to deliver: stem cells in gene therapy . Gene Ther vol. 9 , ( 10 ) 603 - 605 .
Savage P, Cowburn P, Clayton A, Man S, McMichael A, Lemoine N, Epenetos A, Ogg G ( 2002 ) . Induction of viral and tumour specific CTL responses using antibody targeted HLA class I peptide complexes . Br J Cancer vol. 86 , ( 8 ) 1336 - 1342 .
Savage P, Cowburn P, Clayton A, Man S, Lawson T, Ogg G, Lemoine N, McMichael A et al. ( 2002 ) . Anti-viral cytotoxic T cells inhibit the growth of cancer cells with antibody targeted HLA class I/peptide complexes in SCID mice . Int J Cancer vol. 98 , ( 4 ) 561 - 566 .
Pasquini S, Peralta S, Missiaglia E, Carta L, Lemoine NR ( 2002 ) . Prime-boost vaccines encoding an intracellular idiotype/GM-CSF fusion protein induce protective cell-mediated immunity in murine pre-B cell leukemia . Gene Ther vol. 9 , ( 8 ) 503 - 510 .
Aspinall RJ, Simmons CP, Petrovska L, Clare S, Khan S, Stratford R, Shea J, Holden DW et al. ( 2002 ) . Selective delivery of antigen to the class I MHC pathway by SifA-mutant Salmonella typhimurium - An assessment of vaccine vector potential . GASTROENTEROLOGY vol. 122 , ( 4 ) A535 - A535 .
Missiaglia E, Moore PS, Williamson J, Lemoine NR, Falconi M, Zamboni G, Scarpa A ( 2002 ) . Sex chromosome anomalies in pancreatic endocrine tumors . Int J Cancer vol. 98 , ( 4 ) 532 - 538 .
Lemoine N ( 2002 ) . 10th International Conference on Gene Therapy of Cancer. 13-15 December, 2001, Sidney Kimmel Cancer Center, San Diego, CA, USA . Expert Rev Anticancer Ther vol. 2 , ( 1 ) 9 - 11 .
Scarpa A, Orlandini S, Moore PS, Lemoine NR, Beghelli S, Baron A, Falconi M, Zamboni G ( 2002 ) . Dpc4 is expressed in virtually all primary and metastatic pancreatic endocrine carcinomas . VIRCHOWS ARCH vol. 440 , ( 2 ) 155 - 159 .
Martins LM, Iaccarino I, Tenev T, Gschmeissner S, Totty NF, Lemoine NR, Savopoulos J, Gray CW et al. ( 2002 ) . The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif . J Biol Chem vol. 277 , ( 1 ) 439 - 444 .
Terris B, Blaveri E, Crnogorac-Jurcevic T, Jones M, Missiaglia E, Lemoine N ( 2002 ) . Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas . MODERN PATHOL vol. 15 , ( 1 ) 294A - 295A .
Sirivatanauksorn Y, Sirivatanauksorn V, Lemoine NR ( 2002 ) . DNA fingerprinting from cells captured by laser microdissection . Methods Enzymol vol. 356 , 289 - 294 .
Glorioso J, Lemoine N ( 2002 ) . Electronic submission, review and tracking system for gene therapy . GENE THER vol. 9 , ( 1 ) 1 - 1 .
Hawkins LK, Lemoine NR, Kirn D ( 2002 ) . Oncolytic biotherapy: a novel therapeutic platform . LANCET ONCOL vol. 3 , ( 1 ) 17 - 26 .
Crnogorac-Jurcevic T, Nielsen TO, Lemoine NR ( 2002 ) . RT-PCR from laser-capture microdissected samples . Methods Mol Biol vol. 193 , 197 - 204 .
Sirivatanauksorn V, Sirivatanauksorn Y, McKie AB, Lemoine NR ( 2002 ) . Use of DNA fingerprinting to detect genetic rearrangements in human cancer . Methods Mol Med vol. 68 , 107 - 114 .
El-Hariry I, Pignatelli M, Lemoine NR ( 2001 ) . FGF-1 and FGF-2 regulate the expression of E-cadherin and catenins in pancreatic adenocarcinoma . Int J Cancer vol. 94 , ( 5 ) 652 - 661 .
Moore PS, Sipos B, Orlandini S, Sorio C, Real FX, Lemoine NR, Gress T, Bassi C et al. ( 2001 ) . Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4 . Virchows Arch vol. 439 , ( 6 ) 798 - 802 .
Lemoine NR, Tenev T, McNeish L, Stoll V, Marani M, Vassaux G ( 2001 ) . Targeting suicide genes for cancer gene therapy . CANCER GENE THER vol. 8 , S17 - S17 .
Rigg AS, Lemoine NR ( 2001 ) . Adenoviral delivery of TIMP1 or TIMP2 can modify the invasive behavior of pancreatic cancer and can have a significant antitumor effect in vivo . CANCER GENE THER vol. 8 , ( 11 ) 869 - 878 .
Crnogorac-Jurcevic T, Efthimiou E, Capelli P, Blaveri E, Baron A, Terris B, Jones M, Tyson K et al. ( 2001 ) . Gene expression profiles of pancreatic cancer and stromal desmoplasia . Oncogene vol. 20 , ( 50 ) 7437 - 7446 .
Lemoine N ( 2001 ) . Genome medicine: gene therapy for the new millennium . IDrugs vol. 4 , ( 11 ) 1247 - 1249 .
Lemoine N ( 2001 ) . Tumor-selective transcriptional targeting for cancer gene therapy . CANCER GENE THER vol. 8 , ( 9 ) 691 - 691 .
Lemoine N ( 2001 ) . American Society of Gene Therapy - Fourth Annual Meeting. Emerging technologies. 30 May-3 June 2001, Seattle, WA, USA . IDrugs vol. 4 , ( 8 ) 901 - 903 .
Madhusudan S, Bates N, Flanagan E, Charnock FMC, Gore M, Barton DPJ, Harper, Karapetis C et al. ( 2001 ) . A multicentre phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with epithelial overian cancer overexpressing HER-2/neu . BRIT J CANCER vol. 85 , 26 - 26 .
Sirivatanauksorn Y, Sirivatanauksorn V, Lemoine NR, Williamson RC, Davidson BR ( 2001 ) . Genomic homogeneity in fibrolamellar carcinomas . Gut vol. 49 , ( 1 ) 82 - 86 .
El-Hariry I, Pignatelli M, Lemoine NR ( 2001 ) . FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines . BRIT J CANCER vol. 84 , ( 12 ) 1656 - 1663 .
McNeish IA, Tenev T, Bell S, Marani M, Vassaux G, Lemoine N ( 2001 ) . Herpes simplex virus thymidine kinase/ganciclovir-induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells . CANCER GENE THER vol. 8 , ( 4 ) 308 - 319 .
Ariaens A, Taniguchi T, Crnogorac-Jurcevic T, Lemoine NR ( 2001 ) . Investigation of expression profiles associated with factor VIIa activation of TF signalling and TIMP1 upregulation in human pancreatic adenocarcinoma cells . J PATHOL vol. 193 , 27A - 27A .
Tenev T, Marani M, McNeish I, Lemoine NR ( 2001 ) . Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors . CELL DEATH DIFFER vol. 8 , ( 3 ) 256 - 264 .
Ghaneh P, Greenhalf W, Humphreys M, Wilson D, Zumstein L, Lemoine NR, Neoptolemos JP ( 2001 ) . Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo . Gene Ther vol. 8 , ( 3 ) 199 - 208 .
Efthimiou E, Crnogorac-Jurcevic T, Lemoine NR ( 2001 ) . Inherited predisposition to pancreatic cancer . GUT vol. 48 , ( 2 ) 143 - 147 .
Sirivatanauksorn V, Sirivatanauksorn Y, Gorman PA, Davidson JM, Sheer D, Moore PS, Scarpa A, Edwards PAW et al. ( 2001 ) . Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping . INT J CANCER vol. 91 , ( 3 ) 350 - 358 .
Moore PS, Orlandini S, Zamboni G, Capelli P, Rigaud G, Falconi M, Bassi C, Lemoine NR et al. ( 2001 ) . Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis . BRIT J CANCER vol. 84 , ( 2 ) 253 - 262 .
Efthimiou E, Crnogorac-Jurcevic T, Lemoine NR ( 2001 ) . Pancreatic cancer genetics . Pancreatology vol. 1 , ( 6 ) 571 - 575 .
Martín-Duque P, Vassaux G, Lemoine N, Ramón y Cajal S ( 2001 ) . Prospects in cancer gene therapy . Oncologia vol. 24 , ( 6 ) 20 - 31 .
Rigaud G, Moore PS, Zamboni G, Orlandini S, Taruscio D, Paradisi S, Lemoine NR, Klöppel G et al. ( 2000 ) . Allelotype of pancreatic acinar cell carcinoma . International Journal of Cancer vol. 88 , ( 5 ) 772 - 777 .
Zhao J, Tenev T, Martins LM, Downward J, Lemoine NR ( 2000 ) . The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner . J CELL SCI vol. 113 , ( 23 ) 4363 - 4371 .
Kawesha A, Ghaneh P, Andrén-Sandberg A, Ögraed D, Skar R, Dawiskiba S, Evans JD, Campbell F et al. ( 2000 ) . K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, ERBB-2 and ERBB-3 in resected pancreatic ductal adenocarcinoma . International Journal of Cancer vol. 89 , ( 6 ) 469 - 474 .
Aspinall RJ, Lemoine NR ( 2000 ) . Suicide and the not-so-innocent bystander . Gut vol. 47 , ( 3 ) 327 - 328 .
Scarpa A, Di Pace C, Talamini G, Falconi M, Lemoine NR, Iacono C, Achille A, Baron A et al. ( 2000 ) . Cancer of the ampulla of Vater: Chromosome 17p allelic loss is associated with poor prognosis . Gut vol. 46 , ( 6 ) 842 - 848 .
Taniguchi T, Lemoine NR ( 2000 ) . Application of suppression subtractive hybridisation for identification of genes regulated by the TF-FVIIa pathway in pancreatic cancer . MOLECULAR PATHOGENESIS OF PANCREATIC CANCER . Editors: Gress, TM , vol. 41 , 57 - 59 .
Vile R, Russell SJ, Lemoine NR ( 2000 ) . Cancer gene therapy: Hard lessons and new courses . Gene Therapy vol. 7 , ( 1 ) 2 - 8 .
Vassaux G, Lemoine NR ( 2000 ) . Gene therapy for carcinoma of the breast - Genetic toxins . BREAST CANCER RES vol. 2 , ( 1 ) 22 - 27 .
Lemoine NR, Sirivatanauksorn V, Crnogorac-Jurcevic T ( 2000 ) . Molecular profile of pancreatic cancer . MOLECULAR PATHOGENESIS OF PANCREATIC CANCER . Editors: Gress, TM , vol. 41 , 4 - 16 .
Lane R, Lemoine N, Hall C, Coats D ( 2000 ) . Oncology and the media . The lancet oncology vol. 1 , ( 4 ) 246 - 249 .
Ogg GS, Dunbar PR, Cerundolo V, McMichael AJ, Lemoine NR, Savage P ( 2000 ) . Sensitization of tumour cells to lysis by virus-specific CTL using antibody-targeted MHC class I/peptide complexes . British Journal of Cancer vol. 82 , ( 5 ) 1058 - 1062 .
Thatcher NJ, Edwards RJ, Lemoine NR, Doehmer J, Davies DS ( 2000 ) . The potential of acetaminophen as a prodrug in gene-directed enzyme prodrug therapy . Cancer Gene Therapy vol. 7 , ( 4 ) 521 - 525 .
Sirivatanauksorn Y, Sirivatanauksorn V, Bhattacharya S, Davidson BR, Dhillon AP, Kakkar AK, Williamson RCN, Lemoine NR ( 1999 ) . Evolution of genetic abnormalities in hepatocellular carcinomas demonstrated by DNA fingerprinting . Journal of Pathology vol. 189 , ( 3 ) 344 - 350 .
Sirivatanauksorn Y, Drury R, Crnogorac-Jur¿evi¿ T, Sirivatanauksorn V, Lemoine NR ( 1999 ) . Laser-assisted microdissection: Applications in molecular pathology . Journal of Pathology vol. 189 , ( 2 ) 150 - 154 .
Habib NA, Hodgson H, Lemoine N, Pignatelli M ( 1999 ) . A phase I/II study of hepatic artery infusion with wtp53-CMV-Ad in metastatic malignant liver tumours . Human Gene Therapy vol. 10 , ( 12 ) 2019 - 2034 .
Kakkar AK, Chinswangwatanakul V, Lemoine NR, Tebbutt S, Williamson RCN ( 1999 ) . Role of tissue factor expression on tumour cell invasion and growth of experimental pancreatic adenocarcinoma . British Journal of Surgery vol. 86 , ( 7 ) 890 - 894 .
Melcher A, Todryk S, Bateman A, Chong H, Lemoine NR, Vile RG ( 1999 ) . Adoptive transfer of immature dendritic cells with autologous or allogeneic tumor cells generates systemic antitumor immunity . Cancer Research vol. 59 , ( 12 ) 2802 - 2805 .
El-Hariry I, Jordinson M, Lemoine N, Pignatelli M ( 1999 ) . Characterization of the E-cadherin-catenin complexes in pancreatic carcinoma cell lines . Journal of Pathology vol. 188 , ( 2 ) 155 - 162 .
Vassaux G, Hurst HC, Lemoine NR ( 1999 ) . Insulation of a conditionally expressed transgene in an adenoviral vector . Gene Therapy vol. 6 , ( 6 ) 1192 - 1197 .
Schmitt JF, Keogh MC, Dennehy U, Chen D, Lupu F, Weston K, Taylor D, Kakkar VV et al. ( 1999 ) . Tissue-selective expression of dominant-negative proteins for the regulation of vascular smooth muscle cell proliferation . Gene Therapy vol. 6 , ( 6 ) 1184 - 1191 .
Pandha HS, Bateman AR, Lemoine NR ( 1999 ) . Dendritic cells in cancer immunotherapy . Drug News and Perspectives vol. 12 , ( 3 ) 165 - 174 .
Keogh MC, Chen D, Schmitt JF, Dennehy U, Kakkar VV, Lemoine NR ( 1999 ) . Design of a muscle cell-specific expression vector utilising human vascular smooth muscle α-actin regulatory elements . Gene Therapy vol. 6 , ( 4 ) 616 - 628 .
Chinswangwatanakul V, Worthington T, Lemoine NR, Williamson RCN, Kakkar AK ( 1999 ) . Circulating vascular endothelial growth factor correlates with systemic thrombin generation in patients with pancreatic carcinoma [6] . Thrombosis and Haemostasis vol. 81 , ( 5 )
Aspinall RJ, Lemoine NR ( 1999 ) . Gene therapy for pancreatic and biliary malignancies . Annals of Oncology . vol. 10 ,
Lemoine NR, Glorioso JC ( 1999 ) . Gene therapy for the millenium: In with the new . Gene Therapy vol. 6 , ( 7 )
Pandha HS, Martin LA, Rigg A, Hurst HC, Stamp GWH, Sikora K, Lemoine NR ( 1999 ) . Genetic prodrug activation therapy for breast cancer: A phase I clinical trial of erbB-2-directed suicide gene expression . Journal of Clinical Oncology vol. 17 , ( 7 ) 2180 - 2189 .
Rigg AS, Lemoine NR ( 1999 ) . Genetic prodrug activation therapy for pancreatic cancer . Annals of the New York Academy of Sciences . vol. 880 , 319 - 325 .
Sirivatanauksorn Y, Sirivatanauksorn V, Bhattacharya S, Davidson BR, Dhillon AP, Kakkar AK, Williamson RCN, Lemoine NR ( 1999 ) . Genomic heterogeneity in synchronous hepatocellular carcinomas . Gut vol. 45 , ( 5 ) 761 - 765 .
Rigg AS, Scarpa A, Pandha HS, Lemoine NR ( 1998 ) . Gene therapy for pancreatic cancer . Italian Journal of Gastroenterology and Hepatology vol. 30 , ( 5 ) 462 - 466 .
Taniguchi T, Kakkar AK, Tuddenham EGD, Williamson RCN, Lemoine NR ( 1998 ) . Enhanced expression of urokinase receptor induced through the tissue factor-factor VIIa pathway in human pancreatic cancer . Cancer Research vol. 58 , ( 19 ) 4461 - 4467 .
Hoorens A, Prenzel K, Lemoine NR, Klöppel G ( 1998 ) . Undifferentiated carcinoma of the pancreas: Analysis of intermediate filament profile and Ki-ras mutations provides evidence of a ductal origin . Journal of Pathology vol. 185 , ( 1 ) 53 - 60 .
Zbar AP, Lemoine NR, Wadhwa M, Thomas H, Snary D, Kmiot WA ( 1998 ) . Biological therapy: Approaches in colorectal cancer. Strategies to enhance carcinoemhryonic antigen (CEA) as an immunogenic target . British Journal of Cancer vol. 77 , ( 5 ) 683 - 693 .
Todryk SM, Chong H, Vile RG, Pandha H, Lemoine NR ( 1998 ) . Can immunotherapy by gene transfer tip the balance against colorectal cancer? . Gut vol. 43 , ( 4 ) 445 - 449 .
Sirivatanauksorn V, Sirivatanauksorn Y, Lemoine NR ( 1998 ) . Molecular pattern of ductal pancreatic cancer . Langenbeck's Archives of Surgery vol. 383 , ( 2 ) 105 - 115 .
Taniguchi T, Rigg A, Lemoine NR ( 1998 ) . Targeting angiogenesis: Genetic intervention which strikes at the weak link of tumorigenesis . Gene Therapy vol. 5 , ( 8 ) 1011 - 1013 .
Lemoine N ( 1998 ) . Tumour-selective targeting of prodrug activation . British Journal of Cancer . vol. 78 ,
Taniguchi T, Lemoine NR, Kakkar AK ( 1998 ) . Urokinase receptor is a key player in tumour progression . Gut vol. 43 , ( 6 ) 739 - 740 .
Martin LA, Vile R, Lemoine NR, Sikora K, Pandha HS ( 1997 ) . Genetic prodrug activation therapy . Lancet vol. 350 , ( 9094 ) 1793 - 1794 .
Bramhall SR, Neoptolemos JP, Stamp GWH, Lemoine NR ( 1997 ) . Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma . Journal of Pathology vol. 182 , ( 3 ) 347 - 355 .
Kashiwagi H, Spigelman AD, Talbot IC, Debinski HS, McKie AB, Lemoine NR, Phillips RKS ( 1997 ) . p53 and K-ras status in duodenal adenomas in familial adenomatous polyposis . British Journal of Surgery vol. 84 , ( 6 ) 826 - 829 .
McKie AB, Iwamura T, Leung HY, Hollingsworth MA, Lemoine NR ( 1997 ) . Alu-polymerase chain reaction genomic fingerprinting technique identifies multiple genetic loci associated with pancreatic tumourigenesis . Genes Chromosomes and Cancer vol. 18 , ( 1 ) 30 - 41 .
Barton C, Lemoine N, Iversen PL, Bishop MR ( 1997 ) . Antisense oligonucleotides targeting p53 [1] (multiple letters) . Journal of Clinical Oncology vol. 15 , ( 1 )
Scupoli MT, Sartoris S, Tosi G, Ennas MG, Nicolis M, Cestari T, Zamboni G, Martignoni G et al. ( 1997 ) . Erratum: Expression of MHC class I and class II antigens in pancreatic adenocarcinomas (Tissue Antigens (1996) 48 (301-311)) . Tissue Antigens vol. 49 , ( 4 )
El-Hariry I, Pignatelli M, Lemoine N ( 1997 ) . Fibroblast growth factor 1 and fibroblast growth factor 2 immunoreactivity in gastrointestinal tumours . Journal of Pathology vol. 181 , ( 1 ) 39 - 45 .
Keogh MC, Chen D, Lupu F, Shaper N, Schmitt JF, Kakkar W, Lemoine NR ( 1997 ) . High efficiency reporter gene transfection of vascular tissue in vitro and in vivo using a cationic lipid-DNA complex . Gene Therapy vol. 4 , ( 2 ) 162 - 171 .
Lemoine NR ( 1997 ) . Molecular advances in pancreatic cancer . Digestion vol. 58 , ( 6 ) 550 - 556 .
Lemoine NR, Wynford-Thomas D ( 1997 ) . Transfection and transformation of human thyroid epithelial cells . Methods in molecular biology (Clifton, N.J.) vol. 75 , 441 - 447 .
Ring CJA, Blouin P, Martin LA, Hurst HC, Lemoine NR ( 1997 ) . Use of transcriptional regulatory elements of the MUC-1 and ERBB2 genes to drive tumour-selective expression of a prodrug activating enzyme . Gene Therapy vol. 4 , ( 10 ) 1045 - 1052 .
Ring CJA, Harris JD, Hurst HC, Lemoine NR ( 1996 ) . Suicide gene expression induced in tumour cells transduced with recombinant adenoviral, retroviral and plasmid vectors containing the ERBB2 promoter . Gene Therapy vol. 3 , ( 12 ) 1094 - 1103 .
Achille A, Scupoli MT, Magalini AR, Zamboni G, Romanelli MG, Orlandini S, Biasi MO, Lemoine NR et al. ( 1996 ) . APC gene mutations and allelic losses in sporadic ampullary tumours: Evidence of genetic difference from tumours associated with familial adenomatous polyposis . International Journal of Cancer vol. 68 , ( 3 ) 305 - 312 .
Larkin DFP, Oral HB, Ring CJA, Lemoine NR, George AJT ( 1996 ) . Adenovirus-mediated gene delivery to the corneal endothelium . Transplantation vol. 61 , ( 3 ) 363 - 370 .
Martin LA, Lemoine NR ( 1996 ) . Direct cell killing by suicide genes . Cancer and Metastasis Reviews vol. 15 , ( 3 ) 301 - 316 .
Scupoli MT, Sartoris S, Tosi G, Ennas MG, Nicolis M, Cestari T, Zamboni G, Martignoni G et al. ( 1996 ) . Expression of MHC class I and class II antigens in pancreatic adenocarcinomas . Tissue Antigens vol. 48 , ( 4 I ) 301 - 311 .
Bramhall SR, Stamp GWH, Dunn J, Lemoine NR, Neoptolemos JP ( 1996 ) . Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease . British Journal of Cancer vol. 73 , ( 8 ) 972 - 978 .
Pandha HS, Lemoine NR ( 1996 ) . Gene therapy in gastroenterology . Gut vol. 38 , ( 2 ) 161 - 165 .
Harris JD, Lemoine NR ( 1996 ) . Strategies for targeted gene therapy . Trends in Genetics vol. 12 , ( 10 ) 400 - 405 .
Di Renzo MF, Poulsom R, Olivero M, Comoglio PM, Lemoine NR ( 1995 ) . Expression of the Met/Hepatocyte Growth Factor Receptor in Human Pancreatic Cancer . Cancer Research vol. 55 , ( 5 ) 1129 - 1138 .
Oda T, Scarpa A, Fukao K, Lemoine NR, Hirohashi S ( 1995 ) . Abnormal expression of E-cadherin in human pancreatic carcinoma cell lines . Nippon rinsho. Japanese journal of clinical medicine vol. 53 , ( 7 ) 1595 - 1601 .
Barton CM, McKie AB, Hogg A, Bia B, Elia G, Phillips SMA, Ding S, Lemoine NR ( 1995 ) . Abnormalities of the RB1 and DCC tumor suppressor genes: Uncommon in human pancreatic adenocarcinoma . Molecular Carcinogenesis vol. 13 , ( 2 ) 61 - 69 .
Barton CM, Lemoine NR ( 1995 ) . Antisense oligonucleotides directed against p53 have antiproliferative effects unrelated to effects on p53 expression . British Journal of Cancer vol. 71 , ( 3 ) 429 - 437 .
Carter G, Gilbert C, Lemoine NR ( 1995 ) . Effects of antisense oligonucleotides targeting K-ras expression in pancreatic cancer cell lines . International Journal of Oncology vol. 6 , ( 5 ) 1105 - 1112 .
Kakkar AK, Lemoine NR, Stone SR, Altieri D, Williamson RCN ( 1995 ) . Identification of a thrombin receptor with factor Xa receptor and tissue factor in human pancreatic carcinoma cells . Journal of Clinical Pathology - Clinical Molecular Pathology vol. 48 , ( 5 )
Pignatelli M, Ansari TW, Gunter P, Liu D, Hirano S, Takeichi M, Kloppel G, Lemoine NR ( 1995 ) . Loss of membranous E-cadherin expression in pancreatic cancer: Correlation with lymph node metastasis, high grade, and advanced stage . Journal of Pathology vol. 176 , ( 4 ) 243 - 248 .
Lemoine NR ( 1995 ) . Oncogenes and cancer markers . Molecular Medicine Today vol. 1 , ( 4 ) 164 - 165 .
Kakkar AK, Lemoine NR, Scully MF, Tebbutt S, Williamson RCN ( 1995 ) . Tissue factor expression correlates with histological grade in human pancreatic cancer . British Journal of Surgery vol. 82 , ( 8 ) 1101 - 1104 .
Lemoine NR ( 1995 ) . Type-1 growth factor receptors in pancreatic and gastrointestinal neoplasia . European Journal of Gastroenterology and Hepatology vol. 7 , ( 10 ) 939 - 944 .
Harris JD, Gutierrez AA, Hurst HC, Sikora K, Lemoine NR ( 1994 ) . Gene therapy for cancer using tumour-specific prodrug activation . Gene Therapy vol. 1 , ( 3 ) 170 - 175 .
Ali M, Lemoine NR, Ring CJA ( 1994 ) . The use of DNA viruses as vectors for gene therapy . Gene Therapy vol. 1 , ( 6 ) 367 - 384 .
Hoorens A, Klöppel G, Gebhard F, Kraft K, Lemoine NR ( 1994 ) . Pancreatoblastoma in an adult: its separation from acinar cell carcinoma . Virchows Archiv vol. 424 , ( 5 ) 485 - 490 .
Leung HY, Gullick WJ, Lemoine NR ( 1994 ) . Expression and functional activity of fibroblast growth factors and their receptors in human pancreatic cancer . International Journal of Cancer vol. 59 , ( 5 ) 667 - 675 .
Lemoine NR ( 1994 ) . Genetic intervention for therapy and prevention of pancreatic cancer . Digestive Surgery vol. 11 , ( 3-6 ) 170 - 177 .
Lemoine N, Beauchamp D ( 1994 ) . Growth factors and receptors . International Journal of Pancreatology . vol. 16 , 250 - 251 .
Lemoine NR, Hurst HC ( 1994 ) . Introduction . European Journal of Cancer vol. 30 , ( 13 )
Leung HY, Hughes CM, Kloppel G, Williamson RCN, Lemoine NR ( 1994 ) . Localisation of expression of fibroblast growth factors and their receptors in pancreatic adenocarcinoma by in situ hybridisation . International Journal of Oncology vol. 4 , ( 6 ) 1219 - 1223 .
Phillips SMA, Barton CM, Lee SJ, Morton DG, Wallace DMA, Lemoine NR, Neoptolemos JP ( 1994 ) . Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis . British Journal of Cancer vol. 70 , ( 6 ) 1252 - 1257 .
Lemoine NR ( 1994 ) . Molecular biology of breast cancer . Annals of Oncology . vol. 5 ,
Bi S, Barton CM, Lemoine NR, Cross NCP, Goldman JM ( 1994 ) . Retroviral transduction of Philadelphia-positive chronic myeloid leukemia cells with a human mutant p53 cDNA and its effect on in vitro proliferation . Experimental Hematology vol. 22 , ( 1 ) 95 - 99 .
SIKORA K, HARRIS J, HURST H, LEMOINE N ( 1994 ) . Therapeutic Strategies Using c‐erb B‐2 Promoter‐Controlled Drug Activation . Annals of the New York Academy of Sciences vol. 716 , ( 1 ) 115 - 125 .
Gasparini G, Pozza F, Bevilacqua P, Gullick WJ, Lemoine NR, Maluta S, Palma PD, Caffo O et al. ( 1994 ) . c-erbB-3 and c-erbB-2 protein expression in node-negative breast carcinoma-an immunocytochemical study . European Journal of Cancer vol. 30 , ( 1 ) 16 - 22 .
Hoorens A, Lemoine NR, McLellan E, Morohoshi T, Kamisawa T, Heitz PU, Stamm B, Ruschoff J et al. ( 1993 ) . Pancreatic acinar cell carcinoma: An analysis of cell lineage markers, p53 expression, and Ki-ras mutation . American Journal of Pathology vol. 143 , ( 3 ) 685 - 698 .
McKie AB, Lemoine NR, Filipe MI ( 1993 ) . Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer . International Journal of Cancer vol. 55 , ( 4 ) 598 - 603 .
Carter G, Lemoine NR ( 1993 ) . Antisense technology for cancer therapy: Does it make sense? . British Journal of Cancer vol. 67 , ( 5 ) 869 - 876 .
Wyllie FS, Lemoine NR, Barton CM, Dawson T, Bond J, Wynford¿Thomas D ( 1993 ) . Direct growth stimulation of normal human epithelial cells by mutant p53 . Molecular Carcinogenesis vol. 7 , ( 2 ) 83 - 88 .
Rajkumar T, Goden CSR, Lemoine NR, Gullick WJ ( 1993 ) . Expression of the C‐erbB‐3 protein in gastrointestinal tract tumours determined by monoclonal antibody RTJ1 . The Journal of Pathology vol. 170 , ( 3 ) 271 - 278 .
Sanidas EE, Filipe MI, Linehan J, Lemoine NR, Gullick WJ, Rajkumar T, Levison DA ( 1993 ) . Expression of the c‐erbB‐3 gene product in gastric cancer . International Journal of Cancer vol. 54 , ( 6 ) 935 - 940 .
McLellan EA, Owen RA, Stepniewska KA, Sheffield JP, Lemoine NR ( 1993 ) . High frequency of K-ras mutations in sporadic colorectal adenomas . Gut vol. 34 , ( 3 ) 392 - 396 .
Burns J, Barton C, Wynford-Thomas D, Lemoine N ( 1993 ) . In vitro transformation of epithelial cells by ras oncogenes . Epithelial Cell Biology vol. 2 , ( 1 ) 26 - 43 .
Lemoine NR, Sikora K ( 1993 ) . Interventional genetics and cancer treatment . British Medical Journal vol. 306 , ( 6879 ) 665 - 666 .
Hall PA, Lemoine NR ( 1993 ) . Models of pancreatic cancer . Cancer Surveys vol. 16 , 135 - 155 .
Gasparini G, Gullick WJ, Bevilacqua P, Pozza F, Lemoine NR, Meli S, Boracchi P, La Malfa G et al. ( 1993 ) . Pathobiological characteristics of the first primary and risk of metachronous contralateral invasive breast carcinoma: Clinical implications . International Journal of Oncology vol. 2 , ( 5 ) 781 - 790 .
Lemoine NR, Wright NA ( 1993 ) . The molecular pathology of cancer: Introduction . Cancer Surveys vol. 16 , 1 - 2 .
Gutierrez AA, Lemoine NR, Sikora K ( 1992 ) . Gene therapy for cancer . The Lancet vol. 339 , ( 8795 ) 715 - 721 .
Lemoine NR, Hughes CM, Cowell JK ( 1992 ) . Aberrant expression of the tumour suppressor gene p53 is very frequent in Wilms' tumours . The Journal of Pathology vol. 168 , ( 2 ) 237 - 242 .
Barton CM, Staddon SL, Hughes CM, Hall PA, O'Sullivan C, Kloppel G, Theis B, Russell RCG et al. ( 1992 ) . Corrigendum: Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer (British Journal of Cancer (1991) 64 (1076)) . British Journal of Cancer vol. 65 , ( 3 )
Bond J, Dawson T, Lemoine N, Wynford¿Thomas D ( 1992 ) . Effect of serum growth factors and phorbol ester on growth and survival of human thyroid epithelial cells expressing mutant ras . Molecular Carcinogenesis vol. 5 , ( 2 ) 129 - 135 .
Prigent SA, Lemoine NR, Hughes CM, Plowman GD, Selden C, Gullick WJ ( 1992 ) . Expression of the c-erbB-3 protein in normal human adult and fetal tissues . Oncogene vol. 7 , ( 7 ) 1273 - 1278 .
Lemoine NR, Hollywood DP, Hughes CM, Prigent SA, Gullick WJ, Hurst HC ( 1992 ) . Expression of the erbb3 gene product in breast cancer . British Journal of Cancer vol. 66 , ( 6 ) 1116 - 1121 .
Lemoine NR ( 1992 ) . Growth factors and oncogenes . The Journal of Pathology vol. 168 , ( 4 ) 419 - 422 .
Lemoine NR, Leung HY, Gullick WJ ( 1992 ) . Growth factors in the gastrointestinal tract . Gut vol. 33 , ( 10 ) 1297 - 1300 .
Lemoine NR, Jain S, Hughes CM, Staddon SL, Maillet B, Hall PA, Klöppel G ( 1992 ) . Ki-ras oncogene activation in preinvasive pancreatic cancer . Gastroenterology vol. 102 , ( 1 ) 230 - 236 .
Hall PA, Lemoine NR ( 1992 ) . Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas . The Journal of Pathology vol. 166 , ( 2 ) 97 - 103 .
Kennedy RL, Jones TH, Davies R, Justice SK, Lemoine NR ( 1992 ) . Release of interleukin-6 by human thyroid epithelial cells immortalized by simian virus 40 DNA transfection . Journal of Endocrinology vol. 133 , ( 3 ) 477 - 482 .
Lemoine NR, Lobresco M, Leung H, Barton C, Hughes CM, Prigent SA, Gullick WJ, Klöppel G ( 1992 ) . The erbB‐3 Gene in human pancreatic cancer . The Journal of Pathology vol. 168 , ( 3 ) 269 - 273 .
Prigent SA, Lemoine NR ( 1992 ) . The type 1 (EGFR-related) family of growth factor receptors and their ligands . Progress in Growth Factor Research vol. 4 , ( 1 ) 1 - 24 .
Wright PA, Lemoine NR, Goretzki PE, Wyllie FS, Bond J, Hughes C, Roher HD, Williams ED et al. ( 1991 ) . Mutation of the p53 gene in a differentiated human thyroid carcinoma cell line, but not in primary thyroid tumours . Oncogene vol. 6 , ( 9 ) 1693 - 1697 .
Hall PA, Ray A, Lemoine NR, Midgley CA, Krausz T, Lane DP ( 1991 ) . p53 immunostaining as a marker of malignant disease in diagnostic cytopathology . The Lancet vol. 338 , ( 8765 )
Wright PA, Williams ED, Lemoine NR, Wynford-Thomas D ( 1991 ) . Radiation-associated and 'spontaneous' human thyroid carcinomas show a different pattern of ras oncogene mutation . Oncogene vol. 6 , ( 3 ) 471 - 473 .
Lemoine NR, Hughes CM, Gullick WJ, Brown CL, Wynford¿Thomas D ( 1991 ) . Abnormalities of the EGF receptor system in human thyroid neoplasia . International Journal of Cancer vol. 49 , ( 4 ) 558 - 561 .
Barton CM, Staddon SL, Hughes CM, O¿Sullivan C, Lemoine NR, Hall PA, Kl¿ppel G, Theis B et al. ( 1991 ) . Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer . British Journal of Cancer vol. 64 , ( 6 ) 1076 - 1081 .
Lemoine NR, Jain S, Silvestre F, Lopes C, Hughes CM, McLelland E, Gullick WJ, Isabel Filipe M ( 1991 ) . Amplification and overexpression of the EGF receptor and c-erbB-2 proto-oncogenes in human stomach cancer . British Journal of Cancer vol. 64 , ( 1 ) 79 - 83 .
Hall PA, Coates P, Lemoine NR, Horton MA ( 1991 ) . Characterization of integrin chains in normal and neoplastic human pancreas . The Journal of Pathology vol. 165 , ( 1 ) 33 - 41 .
Tuzi NL, Venter DJ, Kumar S, Staddon SL, Lemoine NR, Gullick WJ ( 1991 ) . Expression of growth factor receptors in human brain tumours . British Journal of Cancer vol. 63 , ( 2 ) 227 - 233 .
Gullick WJ, Hughes CM, Mellon K, Neal DE, Lemoine NR ( 1991 ) . Immunohistochemical detection of the epidermal growth factor receptor in paraffin‐embedded human tissues . The Journal of Pathology vol. 164 , ( 4 ) 285 - 289 .
Hall PA, Lemoine NR ( 1991 ) . Koch's postulates revisited . The Journal of Pathology vol. 164 , ( 4 ) 283 - 284 .
Hall PA, Lemoine NR, Murphy G, Dowling RH ( 1991 ) . Molecular differences between human and experimental pancreaticobiliary diversion-induced rat pancreatic neoplasia . Gut vol. 32 , ( 5 ) 533 - 535 .
Barton CM, Hall PA, Hughes CM, Gullick WJ, Lemoine NR ( 1991 ) . Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer . The Journal of Pathology vol. 163 , ( 2 ) 111 - 116 .
Lemoine NR, Staddon S, Bond J, Wyllie FS, Shaw JJ, Wynford-Thomas D ( 1990 ) . Partial transformation of human thyroid epithelial cells by mutant Ha-ras oncogene . Oncogene vol. 5 , ( 12 ) 1833 - 1837 .
Lemoine NR, Staddon S, Dickson C, Barnes DM, Gullick WJ ( 1990 ) . Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer . Oncogene vol. 5 , ( 2 ) 237 - 239 .
Lemoine NR, Wyllie FS, Lillehaug JR, Staddon SL, Hughes CM, Aasland R, Shaw J, Varhaug JE et al. ( 1990 ) . Absence of abnormalities of the c-erbB-1 and c-erbB-2 proto-oncogenes in human thyroid neoplasia . European Journal of Cancer and Clinical Oncology vol. 26 , ( 7 ) 777 - 779 .
Wynford-Thomas D, Bond JA, Wyllie FS, Burns JS, Williams ED, Jones T, Sheer D, Lemoine NR ( 1990 ) . Conditional immortalization of human thyroid epithelial cells: A tool for analysis of oncogene action . Molecular and Cellular Biology vol. 10 , ( 10 ) 5365 - 5377 .
Lemoine NR, Hall PA ( 1990 ) . Growth factors and oncogenes in pancreatic cancer . Bailliere's Clinical Gastroenterology vol. 4 , ( 4 ) 815 - 832 .
Jasani B, Wyllie FS, Wright PA, Lemoine NR, Williams ED, Wynford-Thomas D ( 1990 ) . Immunocytochemically detectable TGF-β associated with malignancy in thyroid epithelial neoplasia . Growth Factors vol. 2 , ( 2 ) 149 - 155 .
Gullick WJ, Lemoine NR, Langbeheim H ( 1990 ) . Letters to the editor . The Journal of Pathology vol. 162 , ( 3 ) 275 - 276 .
Hall PA, Hughes CM, Staddon SL, Richman PI, Gullick WJ, Lemoine NR ( 1990 ) . The c‐erbB‐2 proto‐oncogene in human pancreatic cancer . The Journal of Pathology vol. 161 , ( 3 ) 195 - 200 .
Stratton MR, Marshall CJ, Cooper CS, Nag A, Jones JA, Smith RG, Wright PA, Lemoine NR et al. ( 1989 ) . ALTERED c-H-ras GENE IN NON-NEOPLASTIC TISSUE . The Lancet vol. 333 , ( 8639 ) 668 - 669 .
Lemoine NR, Mayall ES, Jones T, Sheer D, McDermid S, Kendall-Taylor P, Wynford-Thomas D ( 1989 ) . Characterisation of human thyroid epithelial cells immortalised in vitro by simian virus 40 DNA transfection . British Journal of Cancer vol. 60 , ( 6 ) 897 - 903 .
Lemoine NR, Mayall ES, Wyllie FS, Williams ED, Goyns M, Stringer B, Wynford-Thomas D ( 1989 ) . High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis . Oncogene vol. 4 , ( 2 ) 159 - 164 .
Wright PA, Lemoine NR, Mayall ES, Wyllie FS, Hughes D, Williams ED, Wynford-Thomas D ( 1989 ) . Papillary and follicular thyroid carcinomas show a different pattern of ras oncogene mutation . British Journal of Cancer vol. 60 , ( 4 ) 576 - 577 .
Wyllie FS, Lemoine NR, Williams ED, Wynford-Thomas D ( 1989 ) . Structure and expression of nuclear oncogenes in multi-stage thyroid tumorigenesis . British Journal of Cancer vol. 60 , ( 4 ) 561 - 565 .
Burns JS, Lemoine L, Lemoine NR, Williams ED, Wynford-Thomas D ( 1989 ) . Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T . British Journal of Cancer vol. 59 , ( 5 ) 755 - 760 .
Lemoine NR, Mayall ES, Dillwyn Williams E, Thurston V, Wynford-Thomas D ( 1988 ) . Agent-specific ras oncogene activation in rat thyroid tumours . Oncogene vol. 3 , ( 5 ) 541 - 544 .
Lemoine NR, Mayall ES, Wyllie F, Farr CJ, Hughes D, Padua RA, Thurston V, Williams ED et al. ( 1988 ) . Activated ras Oncogenes in Human Thyroid Cancers . Cancer Research vol. 48 , ( 16 ) 4459 - 4463 .
Wyllie FS, Wynford-Thomas V, Lemoine NR, Williams GT, Williams ED, Wynford-Thomas D ( 1988 ) . Ha-ras restriction fragment length polymorphisms in colorectal cancer . British Journal of Cancer vol. 57 , ( 2 ) 135 - 138 .
Lemoine NR, Wynford-Thomas V, Wynford-Thomas D ( 1987 ) . Optimisation of conditions for detection of activated oncogenes by transfection of NIH 3T3 cells . British Journal of Cancer vol. 55 , ( 6 ) 639 - 642 .
Barnard NJ, Hall PA, Lemoine NR, Kadar N ( 1987 ) . Proliferative index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical and pathological variables . The Journal of Pathology vol. 152 , ( 4 ) 287 - 295 .
HALL PA, LEMOINE NR, RYAN JF ( 1986 ) . Carcinoma of the gall bladder metastatic to the cervix. Case report . BJOG: An International Journal of Obstetrics & Gynaecology vol. 93 , ( 11 ) 1187 - 1190 .
Hall PA, Lemoine NR ( 1986 ) . Comparison of manual data coding errors in two hospitals . Journal of Clinical Pathology vol. 39 , ( 6 ) 622 - 626 .
Lemoine NR, Hall PA ( 1986 ) . Epithelial tumors metastatic to the uterine cervix. A study of 33 cases and review of the literature . Cancer vol. 57 , ( 10 ) 2002 - 2005 .
Lemoine NR, Ryan JF, Cox EL, Mayston V, Revell PA, Swash M ( 1986 ) . Immunohistochemical analysis of mononuclear cell subsets in inflammatory and non-inflammatory myopathies . Journal of Clinical Pathology vol. 39 , ( 3 ) 271 - 274 .
WRIGHT S, LEMOINE NR, LEIGH IM ( 1986 ) . Woolly hair naevi with systematized linear epidermal naevus . Clinical and Experimental Dermatology vol. 11 , ( 2 ) 179 - 182 .