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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Peter King

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Novoselova TV, King PJ, Guasti L, Metherell LA, Clark AJL, Chan LF ( 2019 ) . ACTH signalling and adrenal development: Lessons from mouse models . Endocrine Connections vol. 8 , ( 7 ) R122 - R130 .
Hadjidemetriou I, Mariniello K, Ruiz-Babot G, Pittaway J, Mancini A, Mariannis D, Gomez-Sanchez CE, Parvanta L et al. ( 2019 ) . DLK1/PREF1 marks a novel cell population in the human adrenal cortex . The Journal of Steroid Biochemistry and Molecular Biology vol. 193 ,
O’Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM et al. ( 2019 ) . Oncometabolite induced primary cilia loss in pheochromocytoma . Endocrine-Related Cancer vol. 26 , ( 1 ) 165 - 180 .
Novoselova TV, Hussain M, King PJ, Guasti L, Metherell LA, Charalambous M, Clark AJL, Chan LF ( 2018 ) . MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation . FASEB Journal vol. 32 , ( 11 ) 6186 - 6196 .
Read JE, Cabrera-Sharp V, Kitscha P, Cartwright JE, King PJ, Fowkes RC, de Mestre AM ( 2018 ) . Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter . Frontiers in Endocrinology vol. 9 , 195 - 195 .
Johnston ZC, Bellingham M, Filis P, Soffientini U, Hough D, Bhattacharya S, Simard M, Hammond GL et al. ( 2018 ) . The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester . BMC Med vol. 16 , ( 1 ) 23 - 23 .
Ruiz-Babot G, Balyura M, Hadjidemetriou I, Ajodha SJ, Taylor DR, Ghataore L, Taylor NF, Schubert U et al. ( 2018 ) . Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells . Cell Reports vol. 22 , ( 5 ) 1236 - 1249 .
Katugampola H, King PJ, Chatterjee S, Meso M, Duncan AJ, Achermann JC, Guasti L, Ghataore L et al. ( 2017 ) . Kisspeptin is a novel regulator of human fetal adrenocortical development and function – a finding with important implications for the human feto-placental unit . The Journal of Clinical Endocrinology & Metabolism
Cavlan D, Evagora C, Berney D, Storr H, Drake W, King P ( 2016 ) . Adrenal pigmentation in PPNAD is a result of melanin deposition and associated with upregulation of the melanocortin 1 receptor . Endocrine Abstracts
Hawkins KE, Joy S, Delhove JMKM, Kotiadis VN, Fernandez E, Fitzpatrick LM, Whiteford JR, King PJ et al. ( 2016 ) . NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming . Cell Reports vol. 14 , ( 8 ) 1883 - 1891 .
Cavlan D, Storr H, Berney D, Evagora C, King P ( 2015 ) . Adrenal pigmentation in PPNAD is a result of melanin deposition and associated with upregulation of the melanocortin 1 receptor . Endocrine Abstracts
Hadjidemetriou I, Ruiz-Babot G, Gomez-Sanchez C, King P, Guasti L ( 2015 ) . Unveiling the complexity of the undifferentiated zone in the human adrenal cortex . Endocrine Abstracts
Diaz-Cano S, Szyszka P, Weitsman G, Dudka D, King P, Korbonits M, Grossman A, Schulte K-M et al. ( 2015 ) . Effect of Erlotinib on Proliferation and Steriodogenesis in Primary Cultures of Adrenocortical Carcinoma . LABORATORY INVESTIGATION . vol. 95 , 133A - 133A .
Ruiz-Babot G, Hadjidemetriou I, King PJ, Guasti L ( 2015 ) . New directions for the treatment of adrenal insufficiency . Frontiers in Endocrinology vol. 6 , ( MAY )
Katugampola H, Halder W, Ganatra R, Dunkel L, Storr H, Guasti L, King P ( 2014 ) . Expression of Sonic hedgehog signalling components in the developing human adrenal cortex . Endocrine Abstracts
Dworakowska D, Dudka D, Weitsman G, King PJ, Diaz-Cano SJ, Korbonits M, Grossman AB, Aylwin SJB et al. ( 2014 ) . Simultaneous Targeting PI3K/Akt/mTOR and MEK/RAF/ERK Pathways Results in a Synergistic Anti-Proliferative Effect in an Adrenocortical Carcinoma Model . ENDOCRINE REVIEWS vol. 35 , ( 3 )
Dworakowska D, Dudka D, Weistman G, King P, Diaz-Cano S, Korbonits M, Grossman AB, Aylwin S et al. ( 2014 ) . The anti-proliferative effect of anti-EGFR tyrosine kinase inhibitor in combination with mitotane on H295R adrenocortical cancer cells . Endocrine Abstracts
Radian S, King P, Korbonits M ( 2014 ) . Analysis of the AIP gene promoter . Endocrine Abstracts
Dworakowska D, Dudka D, Weitsman G, King P, Katugampola H, Korbonits M, Schulte K-M, Diaz-Cano S et al. ( 2014 ) . Pre-clinical assessment of the impact of Erlotinib on adrenocortical cancer cells proliferation . Endocrine Abstracts
Guasti L, Cavlan D, Cogger K, Banu Z, Shakur A, Latif S, King PJ ( 2013 ) . Dlk1 up-regulates Gli1 expression in male rat adrenal capsule cells through the activation of β1 integrin and ERK1/2 . Endocrinology vol. 154 , ( 12 ) 4675 - 4684 .
Guasti L, Candy Sze WC, McKay T, Grose R, King PJ ( 2013 ) . FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development . Mol Cell Endocrinol vol. 371 , ( 1-2 ) 182 - 188 .
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL et al. ( 2013 ) . Familial glucocorticoid deficiency: New genes and mechanisms . Molecular and Cellular Endocrinology vol. 371 , ( 1-2 ) 195 - 200 .
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL et al. ( 2013 ) . Familial glucocorticoid deficiency: New genes and mechanisms . Mol Cell Endocrinol vol. 371 , ( 1-2 ) 195 - 200 .
Yates R, Katugampola H, Cavlan D, Cogger K, Meimaridou E, Hughes C, Metherell L, Guasti L et al. ( 2013 ) . Adrenocortical development, maintenance, and disease . Curr Top Dev Biol vol. 106 , 239 - 312 .
Cogger K, Guasti L, Ashworth R, Brennan C, Beales P, Marion V, King P ( 2012 ) . The role of primary cilia in mouse adrenal and zebrafish interrenal development . Cilia vol. 1 , ( Suppl 1 )
Marion V, Mockel A, De Melo C, Obringer C, Claussmann A, Simon A, Messaddeq N, Durand M et al. ( 2012 ) . BBS-Induced Ciliary Defect Enhances Adipogenesis, Causing Paradoxical Higher-Insulin Sensitivity, Glucose Usage, and Decreased Inflammatory Response . CELL METABOLISM vol. 16 , ( 3 ) 363 - 377 .
Thompson IR, Chand AN, King PJ, Ansorge O, Karavitaki N, Jones CA, Rahmutula D, Gardner DG et al. ( 2012 ) . Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide . Endocr Relat Cancer vol. 19 , ( 4 ) 497 - 508 .
Meimaridou E, Kowalczyk J, Guasti L, Hughes CR, Wagner F, Frommolt P, Nürnberg P, Mann NP et al. ( 2012 ) . Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency . Nat Genet vol. 44 , ( 7 ) 740 - 742 .
Laufer E, Kesper D, Vortkamp A, King P ( 2012 ) . Sonic hedgehog signaling during adrenal development . MOLECULAR AND CELLULAR ENDOCRINOLOGY vol. 351 , ( 1 ) 19 - 27 .
Hughes CR, Guasti L, Meimaridou E, Chuang C-H, Schimenti JC, King PJ, Costigan C, Clark AJL et al. ( 2012 ) . MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans . JOURNAL OF CLINICAL INVESTIGATION vol. 122 , ( 3 ) 814 - 820 .
Gorrigan RJ, Guasti L, King P, Clark AJ, Chan LF ( 2011 ) . Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland . J Mol Endocrinol vol. 46 , ( 3 ) 227 - 232 .
Guasti L, Paul A, Laufer E, King P ( 2011 ) . Localization of Sonic hedgehog secreting and receiving cells in the developing and adult rat adrenal cortex . Mol Cell Endocrinol vol. 336 , ( 1-2 ) 117 - 122 .
Igreja S, Chahal HS, King P, Bolger GB, Srirangalingam U, Guasti L, Chapple JP, Trivellin G et al. ( 2010 ) . Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families . Hum Mutat vol. 31 , ( 8 ) 950 - 960 .
Laufer E, King P, Paul A ( 2010 ) . Shh signaling regulates adrenocortical development and identifies novel progenitors of steroidogenic lineages . ENDOCR J vol. 57 , S309 - S309 .
King P, Paul A, Laufer E ( 2009 ) . Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages . Proc Natl Acad Sci U S A vol. 106 , ( 50 ) 21185 - 21190 .
Bogdarina IG, King PJ, Clark AJL ( 2009 ) . Characterization of the angiotensin (AT1b) receptor promoter and its regulation by glucocorticoids . J Mol Endocrinol vol. 43 , ( 2 ) 73 - 80 .
Garcia EA, King P, Sidhu K, Ohgusu H, Walley A, Lecoeur C, Gueorguiev M, Khalaf S et al. ( 2009 ) . The role of ghrelin and ghrelin-receptor gene variants and promoter activity in type 2 diabetes . Eur J Endocrinol vol. 161 , ( 2 ) 307 - 315 .
Laufer E, Paul A, King PJ ( 2009 ) . Shh signaling regulates adrenocortical development and identifies novel progenitors of steroidogenic lineages . DEVELOPMENTAL BIOLOGY . vol. 331 , 490 - 490 .
Chung TT, Webb TR, Chan LF, Cooray SN, Metherell LA, King PJ, Chapple JP, Clark AJL ( 2008 ) . The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface . J Clin Endocrinol Metab vol. 93 , ( 12 ) 4948 - 4954 .
King PJ, Guasti L, Laufer E ( 2008 ) . Hedgehog signalling in endocrine development and disease . J ENDOCRINOL vol. 198 , ( 3 ) 439 - 450 .
Janes ME, Chu KME, Clark AJL, King PJ ( 2008 ) . Mechanisms of adrenocorticotropin-induced activation of extracellularly regulated kinase 1/2 mitogen-activated protein kinase in the human H295R adrenal cell line . Endocrinology vol. 149 , ( 4 ) 1898 - 1905 .
Doufexis M, Storr HL, King PJ, Clark AJL ( 2007 ) . Interaction of the melanocortin 2 receptor with nucleoporin 50: evidence for a novel pathway between a G-protein-coupled receptor and the nucleus . FASEB J vol. 21 , ( 14 ) 4095 - 4100 .
Hu L, Monteiro A, Johnston H, King P, O'Shaughnessy PJ ( 2007 ) . Expression of Cyp21a1 and Cyp11b1 in the fetal mouse testis . REPRODUCTION vol. 134 , ( 4 ) 585 - 591 .
Johnston H, King PJ, O'Shaughnessy PJ ( 2007 ) . Effects of ACTH and expression of the melanocortin-2 receptor in the neonatal mouse testis . REPRODUCTION vol. 133 , ( 6 ) 1181 - 1187 .
Bogdarina I, Welham S, King PJ, Burns SP, Clark AJL ( 2007 ) . Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension . Circ Res vol. 100 , ( 4 ) 520 - 526 .
Noon LA, Clark AJL, O'Shaughnessy PJ, King PJ ( 2006 ) . A CCAAT/enhancer-binding protein site at -87 is required for the activation of a novel murine melanocortin 2-receptor promoter at late stages during adipogenesis . Endocrinology vol. 147 , ( 12 ) 6019 - 6026 .
Noon LA, Bakmanidis A, Clark AJL, O'Shaughnessy PJ, King PJ ( 2006 ) . Identification of a novel melanocortin 2 receptor splice variant in murine adipocytes: implications for post-transcriptional control of expression during adipogenesis . J MOL ENDOCRINOL vol. 37 , ( 3 ) 415 - 420 .
White NR, Mulligan P, King PJ, Sanderson IR ( 2006 ) . Sodium butyrate-mediated Sp3 acetylation represses human insulin-like growth factor binding protein-3 expression in intestinal epithelial cells . J Pediatr Gastroenterol Nutr vol. 42 , ( 2 ) 134 - 141 .
Noon LA, Clark AJL, King PJ ( 2004 ) . A peroxisome proliferator-response element in the murine mc2-r promoter regulates its transcriptional activation during differentiation of 3T3-L1 adipocytes . J Biol Chem vol. 279 , ( 22 ) 22803 - 22808 .
King P, CLARK AJL, Noon LA ( 2004 ) . A Peroxisome Proliferator-response Element in the Murine mc2-r Promoter Regulates Its Transcriptional Activation during Differentiation of 3T3-L1 Adipocytes . Journal of Biological Chemistry vol. 279 , ( 22 ) 22803 - 22808 .
Swords FM, Noon LA, King PJ, Clark AJL ( 2004 ) . Constitutive activation of the human ACTH receptor resulting from a synergistic interaction between two naturally occurring missense mutations in the MC2R gene . Mol Cell Endocrinol vol. 213 , ( 2 ) 149 - 154 .
Fowkes RC, Desclozeaux M, Patel MV, Aylwin SJB, King P, Ingraham HA, Burrin JM ( 2003 ) . Steroidogenic factor-1 and the gonadotrope-specific element enhance basal and pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein hormone alpha-subunit gene in gonadotropes . MOL ENDOCRINOL vol. 17 , ( 11 ) 2177 - 2188 .
Fowkes RC, Sidhu KK, Sosabowski JK, King P, Burrin JM ( 2003 ) . Absence of pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein alpha-subunit gene in LbetaT2 gonadotrophs reveals disrupted cAMP-mediated gene transcription . J Mol Endocrinol vol. 31 , ( 2 ) 263 - 278 .
Clark AJL, Baig AH, Noon L, Swords FM, Hunyady L, King PJ ( 2003 ) . Expression, desensitization, and internalization of the ACTH receptor (MC2R) . MELANOCORTIN SYSTEM . Editors: Cone, RD , vol. 994 , 111 - 117 .
Swords FM, Baig A, Malchoff DM, Malchoff CD, Thorner MO, King PJ, Hunyady L, Clark AJL ( 2002 ) . Impaired desensitization of a mutant adrenocorticotropin receptor associated with apparent constitutive activity . Mol Endocrinol vol. 16 , ( 12 ) 2746 - 2753 .
Baig AH, Swords FM, Szaszák M, King PJ, Hunyady L, Clark AJL ( 2002 ) . Agonist activated adrenocorticotropin receptor internalizes via a clathrin-mediated G protein receptor kinase dependent mechanism . Endocr Res vol. 28 , ( 4 ) 281 - 289 .
Kosti O, King PJ, Hinson JP ( 2002 ) . Tumour-derived human adrenocortical cells express beta-adrenergic receptors: steroidogenic effects of beta-adrenergic input . Endocr Res vol. 28 , ( 4 ) 363 - 367 .
Fowkes RC, King P, Burrin JM ( 2002 ) . Regulation of human glycoprotein hormone alpha-subunit gene transcription in L beta T2 gonadotropes by protein kinase C and extracellular signal-regulated kinase 1/2 . BIOL REPROD vol. 67 , ( 3 ) 725 - 734 .
Noon LA, Franklin JM, King PJ, Goulding NJ, Hunyady L, Clark AJL ( 2002 ) . Failed export of the adrenocorticotrophin receptor from the endoplasmic reticulum in non-adrenal cells: evidence in support of a requirement for a specific adrenal accessory factor . J Endocrinol vol. 174 , ( 1 ) 17 - 25 .
Baig AH, Swords FM, Noon LA, King PJ, Hunyady L, Clark AJ ( 2001 ) . Desensitization of the Y1 cell adrenocorticotropin receptor: evidence for a restricted heterologous mechanism implying a role for receptor-effector complexes . J Biol Chem vol. 276 , ( 48 ) 44792 - 44797 .
Newell-Price J, King P, Clark AJ ( 2001 ) . The CpG island promoter of the human proopiomelanocortin gene is methylated in nonexpressing normal tissue and tumors and represses expression . Mol Endocrinol vol. 15 , ( 2 ) 338 - 348 .
KING PJ, Clark AJL, Newell-Price J ( 2001 ) . Methylation of a tissue-specific CpG island in normal non-expressing human tissue . Mol Endo vol. 15 , 338 - 348 .
Newell-Price J, Clark AJL, King P ( 2000 ) . DNA methylation and silencing of gene expression . Trends in Endocrinology and Metabolism vol. 11 , ( 4 ) 142 - 148 .
King PJ, Clark AJL ( 1998 ) . Analysis of the first exon of the murine ACTH receptor gene . Endocrine Research . vol. 24 , 397 - 402 .
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