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Research

Publications: Dr Jeffrey Davies

Hilali A, Hibbs S, Davies J, Smith M ( 2021 ) . Outcomes of allogeneic transplantation with non-myeloablative conditioning in patients with myelodysplastic and overlap syndromes . BRITISH JOURNAL OF HAEMATOLOGY . vol. 193 , 227 - 228 .
Jurgensen-Rauch A, Gibbs S, Farrell M, Aries J, Grantham M, Eccersley L, Gribben J, Hallam S et al. ( 2021 ) . Reduced intensity allogeneic hematopoietic stem cell transplantation is a safe and effective treatment option in high-risk myeloma patients – a single centre experience . British Journal of Haematology vol. 193 , ( 2 ) 420 - 423 .
Rallis KS, Hillyar CRT, Sideris M, Davies JK ( 2021 ) . T-cell-based Immunotherapies for Haematological Cancers, Part A: A SWOT Analysis of Immune Checkpoint Inhibitors (ICIs) and Bispecific T-Cell Engagers (BiTEs) . Anticancer research vol. 41 , ( 3 ) 1123 - 1141 .
Rallis KS, Hillyar CRT, Sideris M, Davies JK ( 2021 ) . T-cell-based Immunotherapies for Haematological Cancers, Part B: A SWOT Analysis of Adoptive Cell Therapies . Anticancer research vol. 41 , ( 3 ) 1143 - 1156 .
Ball J, Clear A, Aries J, Charrot S, Besley C, Mee M, Stagg A, Lindsay J et al. ( 2020 ) . Retinoic acid-responsive CD8 effector T-cells are selectively increased in IL-23-rich tissue in gastrointestinal GvHD . Blood
Aries JA, Davies JK, Auer RL, Hallam SL, Montoto S, Smith M, Sevillano B, Foggo V et al. ( 2020 ) . Clinical Outcome of Coronavirus Disease 2019 in Haemato-oncology Patients . British Journal of Haematology
Aries J, Charrot S, Ball J, Mee M, Theocharidis S, Van Gassen S, Iqbal S, Gribben JG et al. ( 2019 ) . Integrated Immune Signature Analyses Identifies Evolution of Distinct Immunoregulatory Cell Populations Which Control Alloreactivity after Allogeneic HSCT . Blood . vol. 134 , 595 - 595 .
Savoie ML, Davies JK, Cavenagh J, Oakervee H, Sive J, Smith M, Anderson D, Gribben J et al. ( 2019 ) . Low treatment related mortality and relapse leading to excellent outcomes after allogeneic transplantation for acute lymphoblastic leukaemia using a non-myeloablative conditioning without T CELL depletion . BONE MARROW TRANSPLANTATION . vol. 54 , 144 - 145 .
Aries J, Ball J, Charrot S, Mee M, Van Gassen S, Iqbal S, Gribben J, Davies J ( 2019 ) . Novel mass cytometry analysis identifies reciprocal changes in NKREG and CD4EM as the dominant early immune reconstitution signature associated with subsequent acute GVHD after RIC-AHST . BONE MARROW TRANSPLANTATION . vol. 54 , 117 - 118 .
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al. ( 2019 ) . Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma (Leukemia, (2018), 32, 5, (1261-1265), 10.1038/s41375-018-0043-y) . Leukemia vol. 33 , ( 6 )
DAVIES JK, Brennan L, Wingard J, Cogle C, Kapoor N, Shah A, Dey B, Spitzer T et al. ( 2018 ) . Infusion of alloanergized donor lymphocytes after CD34-selected haploidentical myeloablative hematopoietic stem cell transplantation . Clinical Cancer Research
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al. ( 2018 ) . Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma . Leukemia vol. 32 , ( 5 ) 1258 - 1263 .
Ball JA, Clear AJ, Calaminici M, Stagg A, Lindsay J, Gribben JG, Davies J ( 2017 ) . Human Gastro-Intestinal Graft-Versus-Host Disease Is Mediated By Retinoic Acid-Responsive CD8+ Effector T-Cells Under IL-23 Polarising Conditions . Blood . vol. 130 , 77 - 77 .
DAVIES JK, Hassan S, Sarker S, Besley C, Oakervee H, Smith M, Taussig D, Gribben JG et al. ( 2017 ) . Durable graft-versus-leukaemia effects without donor lymphocyte infusions- results of a Phase II study of sequential T-replete allogeneic transplantation for high-risk acute myeloid leukaemia and myelodysplasia . British Journal of Haematology
Davies J ( 2017 ) . Review of ‘Personalized Immunosuppression in Transplantation’ Edited by Michael Oellerich and Amitava Dasgupta . British Journal of Haematology vol. 176 , ( 3 ) 502 - 502 .
Besley C, Kotsiou E, Petty R, Ajanthah S, Chelala C, Ghazaly E, Le Dieu R, Davies J et al. ( 2016 ) . Alloresponses of Human T-Cells from Adult Peripheral Blood and Umbilical Cord Blood Are Differentially Impacted By Lenalidomide . Blood . vol. 128 , 5714 - 5714 .
Kotsiou E, Okosun J, Besley C, Iqbal S, Matthews J, Fitzgibbon J, Gribben J, DAVIES JK ( 2016 ) . TNFRSF14 aberrations in follicular lymphoma increase clinically significant allogeneic T-cell responses . Blood vol. 128 , ( 1 ) 72 - 81 .
Kotsiou E, Gribben JG, Davies JK ( 2016 ) . Allospecific Tregs expanded after anergization remain suppressive in inflammatory conditions but lack expression of gut-homing molecules . Molecular therapy : the journal of the American Society of Gene Therapy vol. 24 , ( 6 ) 1126 - 1134 .
Hassan S, Davies J, Smith M, Tsitsikas D, Oakervee H, Hallam S, Taussig D, Gribben J et al. ( 2015 ) . DURABLE REMISSIONS AFTER SEQUENTIAL TRANSPLANTATION USING T-REPLETE NON-MYELOABLATIVE CONDITIONING FOR RELAPSED/REFRACTORY ACUTE MYELOID LEUKAEMIA AND MYELODYSPLASIA . HAEMATOLOGICA . vol. 100 , 278 - 278 .
Kotsiou E, Guinan E, Gribben J, Davies J ( 2015 ) . Phenotypic and functional stability of regulatory T cells expanded after alloanergization with costimulatory molecule blockade . BONE MARROW TRANSPLANTATION . vol. 50 , S373 - S373 .
Besley CM, Kotsiou E, Petty R, Sangaralingum A, Le Dieu R, Gribben JG, Davies JK ( 2014 ) . Lenalidomide Enhances Human Alloresponses By Increasing Proliferation of Effector Memory CD8 T Cells with Enhanced Polyfunctional Effector Capacity and a Unique Gene Expression Profile . Blood . vol. 124 , 1103 - 1103 .
Kotsiou E, Okosun J, Clear AJ, Iqbal S, Fitzgibbon J, Gribben JG, Davies JK ( 2014 ) . TNFRSF14 aberrations in Follicular Lymphoma B Cells Result in Increased Alloresponses in Vitro and in Vivo . Blood . vol. 124 , 2426 - 2426 .
Besley C, Kotsiou E, Petty R, Sangaralingam A, LeDieu R, Gribben J, Davies J ( 2014 ) . Lenalidomide potentiates human T cell alloresponses by selectively increasing proliferation of alloreactive CD8+cells which exhibit a novel gene expression profile - implications for IMiD therapy after allogeneic haematopoietic stem cell transplant . BRITISH JOURNAL OF HAEMATOLOGY . vol. 165 , 16 - 17 .
Besley C, Kotsiou E, Petty R, Sangaralingam A, LeDieu R, Gribben J, Davies J ( 2014 ) . LENALIDOMIDE POTENTIATES HUMAN T CELL ALLORESPONSES BY SELECTIVELY INCREASING PROLIFERATION OF ALLOREACTIVE CD8+CELLS WHICH EXHIBIT A NOVEL GENE EXPRESSION PROFILE - IMPLICATIONS FOR IMID THERAPY AFTER ALLOGENEIC HAEMATOPOIETIC CELL TRANSPLANT . BONE MARROW TRANSPLANTATION . vol. 49 , S310 - S311 .
Barbon CM, Davies JK, Voskertchian A, Kelner RH, Brennan LL, Nadler LM, Guinan EC ( 2014 ) . Alloanergization of human T cells results in expansion of alloantigen-specific CD8(+) CD28(-) suppressor cells . Am J Transplant vol. 14 , ( 2 ) 305 - 318 .
Kotsiou E, Gribben J, Davies J ( 2013 ) . Phenotypic and functional characterisation of alloantigen-specific regulatory T cells expanded after in vitro anergisation with co-stimulatory molecule blockade . IMMUNOLOGY . vol. 140 , 22 - 22 .
Miraki-Moud F, Anjos-Afonso F, Hodby KA, Griessinger E, Rosignoli G, Lillington D, Jia L, Davies JK et al. ( 2013 ) . Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation . Proc Natl Acad Sci U S A vol. 110 , ( 33 ) 13576 - 13581 .
Davies JK, Taussig D, Oakervee H, Smith M, Agrawal S, Cavenagh JD, Gribben JG ( 2013 ) . Long-term survival with low toxicity after allogeneic transplantation for acute myeloid leukaemia and myelodysplasia using non-myeloablative conditioning without T cell depletion . Br J Haematol vol. 162 , ( 4 ) 525 - 529 .
Riches JC, Davies JK, McClanahan F, Fatah R, Iqbal S, Agrawal S, Ramsay AG, Gribben JG ( 2013 ) . T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production . Blood vol. 121 , ( 9 ) 1612 - 1621 .
Kotsiou E, Davies JK ( 2013 ) . New ways to separate graft-versus-host disease and graft-versus-tumour effects after allogeneic haematopoietic stem cell transplantation . Br J Haematol vol. 160 , ( 2 ) 133 - 145 .
Riches JC, Davies JK, McClanahan F, Fatah R, Iqbal S, Agrawal S, Ramsay AG, Gribben JG ( 2012 ) . Characterizing Immunophenotypic and Functional Pseudo-Exhaustion in T Cells From CLL Patients: The Impact of Lenalidomide . Blood vol. 120 , ( 21 ) 564 - 564 .
Davies JK, Yuk D, Nadler LM, Guinan EC ( 2012 ) . Erratum: Induction of alloanergy in human donor T cells without loss of pathogen or tumor immunity (Transplantation (2008) 86 (854)) . Transplantation vol. 93 , ( 11 )
Auer RL, MacDougall F, Oakervee HE, Taussig D, Davies JK, Syndercombe-Court D, Agrawal S, Cavenagh JD et al. ( 2012 ) . T-cell replete fludarabine/cyclophosphamide reduced intensity allogeneic stem cell transplantation for lymphoid malignancies . Br J Haematol vol. 157 , ( 5 ) 580 - 585 .
DAVIES JK, Gribben JG ( 2012 ) . Blockade of chemotaxis in graft-versus-host disease . New England Journal of Medicine vol. 367 , ( 17 )
DAVIES JK, Barbon CM, Voskertchian A, Nadler LM, Guinan EC ( 2012 ) . Ex vivo alloanergization with belatacept: a strategy to selectively modulate alloresponses after transplantation . Cell Transplantation vol. 21 , ( 9 ) 2047 - 2061 .
Riches JC, Davies J, Iqbal S, Fatah R, Agrawal S, Ramsay AG, Gribben JG ( 2011 ) . T-Cells From Patients with CLL Exhibit Phenotypic and Transcription Factor Profiles of Exhaustion Independent of CMV Serostatus . Blood vol. 118 , ( 21 ) 1780 - 1780 .
Davies J ( 2011 ) . First-line therapy for CML: nilotinib comes of age . Lancet Oncol vol. 12 , ( 9 ) 826 - 827 .
Davies JK ( 2011 ) . Costimulatory blockade with monoclonal antibodies to induce alloanergy in donor lymphocytes . Int J Hematol vol. 93 , ( 5 ) 594 - 601 .
Davies JK, Barbon CM, Voskertchian A, Nadler LM, Guinan EC ( 2011 ) . Es Vivo Costimulatory Blockade with Belatacept Provides a Strategy To Control Alloresponses after Allogeneic Transplantation . AMERICAN JOURNAL OF TRANSPLANTATION . vol. 11 , 93 - 93 .
Mcnamara C, Davies J, Dyer M, Hoskin P, Illidge T, Lyttelton M, Marcus R, Montoto S et al. ( 2011 ) . Guidelines on the investigation and management of follicular lymphoma . British Journal of Haematology
Davies JK, Barbon CM, Voskertchian AR, Nadler LM, Guinan EC ( 2011 ) . Induction of alloantigen-specific anergy in human peripheral blood mononuclear cells by alloantigen stimulation with co-stimulatory signal blockade . J Vis Exp ( 49 )
Riches JC, Davies J, Iqbal S, Fatah R, Agrawal S, Ramsay AG, Gribben JG ( 2011 ) . T-cells from Patients With CLL Exhibit Phenotypic and Transcription Factor Profiles Of Exhaustion Independent of CMV Serostatus . Blood . vol. 118 , 1780 - 1783 .
DAVIES JK, Nadler LM, Guinan EC ( 2010 ) . Alloanergization in Haploidentical Hematopoietic Stem Cell Transplantation . Bone Marrow Transplantation Across Major Genetic Barriers , Editors: Reisner, Y , World Scientific Publishing
Davies JK, Singh H, Huls H, Yuk D, Lee DA, Kebriaei P, Champlin RE, Nadler LM et al. ( 2010 ) . Combining CD19 redirection and alloanergization to generate tumor-specific human T cells for allogeneic cell therapy of B-cell malignancies . Cancer Res vol. 70 , ( 10 ) 3915 - 3924 .
Davies JK, Nadler LM, Guinan EC ( 2010 ) . Alloanergization in haploidentical hematopoietic stem cell transplantation . Bone Marrow Transplantation Across Major Genetic Barriers ,
Davies JK, Nadler LM, Guinan EC ( 2009 ) . Expansion of allospecific regulatory T cells after anergized, mismatched bone marrow transplantation . Sci Transl Med vol. 1 , ( 1 )
Davies JK, De Lima M, Cooper TJN, Spitzer T, Kapoor N, Yuk D, Brennan LL, Thall P et al. ( 2009 ) . Delayed Infusion Of Alloanergized Donor Peripheral Blood Mononuclear Cells (PBMC) Augments Pathogen-Specific Immune Reconstitution After T Cell Depleted (TCD) Haploidentical Hematopoietic Stem Cell Transplantation (HSCT) For High-Risk Acute LEUKEMIA/MDS . Biology of Blood and Marrow Transplantation . vol. 15 , 139 - 139 .
Davies JK, Singh H, Yuk D, Champlin RE, Nadler LM, Guinan EC, Cooper LJN ( 2009 ) . TO AUGMENT A GVL EFFECT AND REDUCE GVHD: ALLOREACTIVITY OF HUMAN CD19-SPECIFIC T CELLS CAN BE REDUCED BY ALLOANERGIZATION WITHOUT REDUCTION OF TUMOR-SPECIFIC KILLING . BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION . vol. 15 , 121 - 121 .
Davies J, Yuk D, Nadler L, Guinan E ( 2008 ) . Alloanergization of HILA-Mismatched Human Donor T Cells Results in the Generation of Allosuppressive CD4(+) T Regulatory Cells Both in Vitro and in Vivo . BLOOD . vol. 112 , 83 - 84 .
Davies J, Yuk D, Nadler L, Guinan E ( 2008 ) . Alloanergization of HLA-Mismatched Human Donor T Cells Results in the Generation of Allosuppressive CD4+ T Regulatory Cells Both in Vitro and in Vivo . Blood vol. 112 , ( 11 ) 207 - 207 .
Davies J, De Lima M, Cooper L, Spitzer T, Kapoor N, Brennan L, Thall P, McMannis J et al. ( 2008 ) . Phase 1 Clinical Study of Adoptive Immunotherapy with Delayed Infusion of Alloanergized Donor T Cells to Improve Immune Reconstution after Haploidentical Stem Cell Transplantation . BLOOD . vol. 112 , 422 - 423 .
Davies J, De Lima M, Cooper L, Spitzer T, Kapoor N, Brennan L, Thall P, McMannis J et al. ( 2008 ) . Phase 1 Clinical Study of Adoptive Immunotherapy with Delayed Infusion of Alloanergized Donor T Cells to Improve Immune Reconstution after Haploidentical Stem Cell Transplantation . Blood vol. 112 , ( 11 ) 1156 - 1156 .
Davies JK, Yuk D, Nadler LM, Guinan EC ( 2008 ) . Induction of alloanergy in human donor T cells without loss of pathogen or tumor immunity . Transplantation vol. 86 , ( 6 ) 854 - 864 .
Davies JK, Gribben JG, Brennan LL, Yuk DG, Nadler LM, Guinan EC ( 2008 ) . Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies . BLOOD vol. 112 , ( 6 ) 2232 - 2241 .
Haining WN, Davies J, Kanzler H, Drury L, Brenn T, Evans J, Angelosanto J, Rivoli S et al. ( 2008 ) . CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans . Clin Cancer Res vol. 14 , ( 17 ) 5626 - 5634 .
Davies J, Gribben J, Brennan L, Nadler L, Guinan E ( 2008 ) . ALLOANERGIZED HLA-MISMATCHED BONE MARROW TRANSPLANTATION - LOW INCIDENCE OF CLINICALLY SIGNIFICANT GVHD AND VIRAL INFECTION RESULTING IN LONG TERM DISEASE FREE SURVIVAL . BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION . Conference: Annual Meeting of the American-Society-for-Blood-and-Marrow-Transplantation ( San Diego, CA ) from: 13/02/2008 to: 17/02/2008 , vol. 14 , 16 - 17 .
Davies J, Yuk D, Brennan L, Nadler L, Guinan E ( 2008 ) . IN VIVO EXPANSION OF CD4+FOXP3+REGULATORY T CELLS MAY CONTRIBUTE TO CONTROL OF ACUTE GVHD AFTER HLA-MISMATCHED ALLOANERGIZED HSCT . BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION . vol. 14 , 18 - 18 .
Haining WN, Kanzler H, Davies J, Drury L, Kutok J, Brenn T, Angelosanto J, Evans J et al. ( 2007 ) . A Novel Role for CpG Oligonucleotides in Tumor Immunotherapy: CpG-ODN Induce Targeted Chemokine-Induced Lymphocyte Migration to the Peripheral Tissues in Humans . Blood vol. 110 , ( 11 ) 1791 - 1791 .
Davies J, Yuk D, Nadler L, Guinan E ( 2007 ) . Donor-derived T cells can be rendered hyporesporisive to alloantigen without loss of pathogen or tumor immune responses . BLOOD . vol. 110 , 237A - 237A .
Davies J, Yuk D, Brennan L, Nadler L, Guinan E ( 2007 ) . In vivo expansion of CD4+ FOXP3+ regulatory T cells may contribute to control of acute GvHD after HLA-mismatched alloanergized HSCT . BLOOD . vol. 110 , 874A - 875A .
Davies JK, Brennan LL, Nadler LM, Guinan EC ( 2007 ) . Ex vivo alloantigen-specific costimulatory blockade in haploidentical bone marrow transplantation (BMT)-results of a pilot clinical study . PEDIATR BLOOD CANCER . vol. 48 , 621 - 621 .
Davies JK, Guinan EC ( 2007 ) . An update on the management of severe idiopathic aplastic anaemia in children . Br J Haematol vol. 136 , ( 4 ) 549 - 564 .
Killick SB, Cavenagh JD, Davies JK, Marsh JCW ( 2006 ) . Low dose antithymocyte globulin for the treatment of older patients with aplastic anaemia . LEUKEMIA RES vol. 30 , ( 12 ) 1517 - 1520 .
Davies JK, Gorgun G, Nadler LM, Guinan EC ( 2006 ) . Effective control of mismatched alloreactivity via ex vivo alloantigen-specific co-stimulatory blockade does not significantly impact pathogen-specific immunity . BLOOD . vol. 108 , 907A - 907A .
Davies JK, Taussig DC, Oakervee H, Davies AJ, AGRAWAL SG, Gribben JG, Lister TA, Cavenagh JD ( 2006 ) . Long-Term Follow-Up After Reduced-Intensity Conditioning Allogeneic Transplantation for Acute Myeloid Leukemia/Myelodysplastic Syndrome: Late CNS Relapses Despite Graft-Versus-Host Disease . Journal of Clinical Oncology vol. 24 , 23e - 25 .
Allard S, Earley J, Davies JK, Cantwell C, Fulkes V ( 2006 ) . Hospital blood transfusion services in a mass casualty situation: lessons to be learned from July 2005 London bombings . BRITISH JOURNAL OF HAEMATOLOGY . vol. 133 , 2 - 2 .
Davies JK, Cavenagh JD ( 2006 ) . The importance of consistent use of denominators across patient groups in assessing responses in clinical trials . BRIT J HAEMATOL vol. 132 , ( 6 ) 794 - 795 .
Addison EG, North J, Bakhsh I, Marden CM, Haq S, Al-Sarraj S, Malayeri R, Wickremasinghe SE et al. ( 2005 ) . Ligation of CD8alpha on human natural killer cells prevents activation-induced apoptosis and enhances cytolytic activity . Immunology vol. 116 , ( 3 ) 354 - 361 .
DAVIES JK, Koh MB, Lowdell MW ( 2004 ) . Antiviral immunity and T-regulatory cell function are retained after selective alloreactive T-cell depletion in both the HLA-identical and HLA-mismatched settings . Biol Blood Marrow Transplant vol. 10 , ( 4 ) 259 - 268 .
Davies JK, Telfer P, Cavenagh JD, Foot N, Neat M ( 2003 ) . Autoimmune cytopenias in the 22q11.2 deletion syndrome . Clin Lab Haematol vol. 25 , ( 3 ) 195 - 197 .
DAVIES JK, Lowdell MW ( 2003 ) . New advances in acute graft-versus-host disease prophylaxis . Transfusion Medicine vol. 13 , ( 6 ) 387 - 397 .
DAVIES JK, Ahktar N, Ranasinge E ( 2001 ) . A Juicy Problem . Lancet vol. 358 , ( 9299 ) 2126 - 2126 .
Papaioannou S, Davies JK, Grant I, Osei E ( 2000 ) . Folate deficiency in pregnancy presenting as acute megaloblastic crisis . Journal of Obstetrics and Gynaecology vol. 20 , ( 2 ) 190 - 190 .
Dunne CA, Davies JK ( 1996 ) . Epidemiology of adult Still's disease . Annals of the Rheumatic Diseases vol. 55 , ( 4 ) 272 - 272 .