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Research

Publications: Prof Francesco Dell'Accio

Nalesso G, Thorup AS, Eldridge SE, De Palma A, Kaur A, Peddireddi K, Blighe K, Rana S et al. ( 2021 ) . Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis . Scientific Reports vol. 11 , ( 1 )
Bharde S, Caxaria S, Dell'Accio F, Sikandar S ( 2021 ) . Update on pain in arthritis . Current opinion in supportive and palliative care vol. 15 , ( 2 ) 99 - 107 .
Eldridge S, Barawi A, Wang H, Roelofs A, Kaneva M, Guan Z, Lydon H, Thomas B et al. ( 2021 ) . AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 1052.1 - 101052 .
Thorup AS, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J et al. ( 2021 ) . OP0200 BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 120.1 - 12121 .
Thomas B, Eldridge S, Nosrati B, Alvarez M, THORUP A-S, Nalesso G, Caxaria S, Barawi A et al. ( 2021 ) . WNT3A-loaded exosomes enable cartilage repair . Journal of Extracellular Vesicles
Kaneva MK, Muley MM, Krustev E, Reid AR, Souza PR, Dell’Accio F, McDougall JJ, Perretti M ( 2021 ) . Alpha-1-antitrypsin reduces inflammation and exerts chondroprotection in arthritis . FASEB Journal vol. 35 , ( 5 )
Chia S-L, Stott B, Miotla-Zarebska J, Riley D, Dell'Accio F, Vincent TL ( 2021 ) . In a surgical model of OA female mice compared to males display pain at an early stage of disease and differential regulation of pain sensitizers . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 102 , 132 - 132 .
Zhu L, Donhou S, Burleigh A, Zarebska JM, Curtinha M, Parisi I, Khan SN, Dell'Accio F et al. ( 2021 ) . TNF alpha-stimulated gene 6 (TSG-6) is weakly chondroprotective in murine OA but does not account for FGF2-mediated joint protection . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 102 , 134 - 134 .
Thorup AS, Dell'Accio F, Eldridge SE ( 2021 ) . Lessons from joint development for cartilage repair in the clinic . Developmental Dynamics vol. 250 , ( 3 ) 360 - 376 .
von Loga IS, Batchelor V, Driscoll C, Burleigh A, Chia SLL, Stott B, Miotla-Zarebska J, Riley D et al. ( 2020 ) . Does Pain at an Earlier Stage of Chondropathy Protect Female Mice Against Structural Progression After Surgically Induced Osteoarthritis? . Arthritis and Rheumatology vol. 72 , ( 12 ) 2083 - 2093 .
Behler-Janbeck F, Schmidt T, Eldridge S, Heeren J, Dell'accio F, Niemeier A ( 2020 ) . LIVER X RECEPTOR ACTIVATION PROTECTS FROM SURGICALLY-INDUCED KNEE OSTEOARTHRITIS IN MICE . OSTEOPOROSIS INTERNATIONAL . vol. 31 , S490 - S490 .
Zhu L, Donhou S, Burleigh A, Zarebska JM, Curtinha M, Parisi I, Khan SN, Dell'Accio F et al. ( 2020 ) . TSG-6 is weakly chondroprotective in murine OA but does not account for FGF2-mediated joint protection . ACR Open Rheumatology
Thorup A-S, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J et al. ( 2020 ) . ROR2 blockade as a therapy for osteoarthritis . Science Translational Medicine vol. 12 , ( 561 )
Eldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, GUAN Z, Lydon H, Thomas B et al. ( 2020 ) . Agrin induces long term osteochondral regeneration by supporting repair morphogenesis . Science Translational Medicine vol. 12 , ( 559 )
Bertrand J, Kräft T, Gronau T, Sherwood J, Rutsch F, Lioté F, Dell'accio F, Lohmann CH et al. ( 2020 ) . BCP crystals promote chondrocyte hypertrophic differentiation in OA cartilage by sequestering Wnt3a . Annals of the Rheumatic Diseases vol. 79 , ( 7 ) 975 - 984 .
Kania K, Colella F, Riemen AH, Wang H, Howard KA, Aigner T, Dell'Accio F, Capellini TD et al. ( 2020 ) . Expression of growth and differentiation factor 5 during joint repair and osteoarthritis . Osteoarthritis and Cartilage . vol. 28 ,
Batchelor V, von Loga IS, Driscoll C, Stott B, Miotla-Zarebska J, Dell'Accio F, Vincent TL ( 2020 ) . IDENTIFICATION OF PUTATIVE SEX-DEPENDENT PAIN PATHWAYS THAT MAY EXPLAIN WHY FEMALE MICE DEVLOP PAIN BEHAVIOUR DESPITE LOWER CHONDROPATHY SCORES . OSTEOARTHRITIS AND CARTILAGE . vol. 28 , S128 - S128 .
Bollmann M, Brinkema H, Piatek S, Walcher F, Alvarez M, Eldridge S, Dell'Accio F, Bertrand J ( 2020 ) . Short term il1ra treatment reduces post-traumatic OA in mouse in vivo and, in vitro, in human cartilage . Osteoarthritis and Cartilage . vol. 28 ,
Kania K, Colella F, Riemen AHK, Wang H, Howard KA, Thomas A, Dell'Accio F, Capellini TD et al. ( 2020 ) . Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis . Scientific Reports vol. 10 , ( 157 )
Muhammad H, Khan SN, Scammahorn JJ, Dell'Accio F, De Bari C, Colella F, Roelofs A, Vincent T ( 2019 ) . FGF2 promotes regeneration of cartilage in vivo by promoting MSC chemokinesis . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 100 , A28 - A28 .
Held A, Bollmann M, Hansen U, Pap T, Dell'Accio F, Prein C, Aszodi A, Clausen-Schaumann H et al. ( 2019 ) . Inhibition of SDC4-LOX mediated extracellular matrix stiffening prevents chondrocyte differentiation in OA cartilage via increased YAP/TAZ signaling . Osteoarthritis and Cartilage . vol. 27 , s150 - s151 .
Kouvatsos N, Dodd R, Mahmood F, Milner CM, Dell'Accio F, Day AJ ( 2018 ) . CXCL6: a glycosaminoglycan-binding chemokine with pro-inflammatory activities that are modulated by heparin and TSG-6 . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 99 , A62 - A62 .
Khan SN, Muhammad H, Scammahorn JJ, Dell'Accio F, Vincent TL ( 2018 ) . Fibroblast growth factor 2 promotes regeneration of cartilage by attracting mesenchymal stem cells to the site of cartilage injury . Osteoarthritis and Cartilage . vol. 26 ,
Thomas BL, Jones HR, Norling LV, Headland SE, Pitzalis C, Dell'Accio F, Perretti M ( 2018 ) . Neutrophil extracellular vesicles have a cartilage protective effect during inflammatory arthritis . Osteoarthritis and Cartilage . vol. 26 , s125 - s126 .
Fallas MA, Caxaria S, Sherwood J, Luyten F, Pitzalis C, Dell'Accio F ( 2018 ) . The role of GCP-2 in cartilage differentiation and repair . Osteoarthritis and Cartilage . vol. 26 ,
Sherwood J, Sambale M, Bertrand J, Dell'Accio F, Pap T ( 2018 ) . Transient receptor potential cation channel (TRPC6) as a regulator of CXCR2-mediated articular cartilage homeostasis . Osteoarthritis and Cartilage . vol. 26 , s96 - s97 .
Rhys HI, Dell'Accio F, Pitzalis C, Moore A, Norling LV, Perretti M ( 2018 ) . Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages . EBioMedicine vol. 29 , 60 - 69 .
Dell'Accio F, Cailotto F ( 2018 ) . Pharmacological blockade of the WNT-beta-catenin signaling: a possible first-in-kind DMOAD . Osteoarthritis and Cartilage vol. 26 , ( 1 ) 4 - 6 .
DELL'ACCIO F, Cailotto F ( 2017 ) . Pharmacological blockade of the WNT-beta-catenin signaling: a possible first-in-kind DMOAD . Osteoarthritis and Cartilage
Luyten FP, Bierma-Zeinstra S, Dell'Accio F, Kraus VB, Nakata K, Sekiya I, Arden NK, Lohmander LS ( 2017 ) . Towards Classification Criteria for Early Osteoarthritis of the Knee . Seminars in Arthritis and Rheumatism
Thorup A-S, Eldridge SE, Caxaria S, Nalesso G, Thomas BL, Pitzalis C, Luyten F, Dell'Accio F ( 2017 ) . A Potency Assay for Assessing the Chondrogenic Efficiency of Bioactive Molecules in Human Cartilage in vivo . Osteoarthritis and Cartilage . vol. 25 ,
Eldridge SE, Thomas BL, Shanmuganathan K, Strachan D, Ali A, Thorup A-S, Caxaria S, Nalesso G et al. ( 2017 ) . Agrin inhibits canonical WNT signalling through LRP4 . Osteoarthritis and Cartilage . vol. 25 ,
Dell'Accio F ( 2017 ) . In Vivo Models of Cartilage Repair and Chondrogenesis . Osteoarthritis and Cartilage . vol. 25 , s1 - s2 .
Sherwood J, Bertrand J, Dell'Accio F, Papy T ( 2017 ) . THE ROLE OF TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPC6 ACTIVITY IN CXCR2-MEDIATED CHONDROCYTE PHENOTYPIC STABILITY . OSTEOARTHRITIS AND CARTILAGE . vol. 25 , S20 - S20 .
Caxaria S, Sherwood J, Roeder E, Luyten F, Pitzalis C, Dell'Accio F ( 2017 ) . The Role of CXCl6 in Cartilage Development and Homeostasis . Osteoarthritis and Cartilage . vol. 25 ,
Sherwood J, Bertrand J, Dell'Accio F, Pap T ( 2017 ) . The role of transient receptor potential cation channel trpc6 activity in cxcr2-mediated chondrocyte phenotypic stability . Osteoarthritis and Cartilage vol. 25 ,
Thomas BL, Nalesso G, Eldridge SE, Pitzalis C, Dell'accio F ( 2017 ) . WNT16 is up-regulated in the joint following inflammation . Osteoarthritis and Cartilage . vol. 25 ,
Lin NY, Distler A, Beyer C, Philipi-Schöbinger A, Breda S, Dees C, Stock M, Tomcik M et al. ( 2016 ) . Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis . Annals of the Rheumatic Diseases vol. 75 , ( 11 ) 2037 - 2044 .
Sherwood J, Bertrand J, Dell'Accio F, Pap T ( 2016 ) . Maintenance of Chondrocyte Phenotypic Stability By TRPC6 Calcium Channel Activity . ARTHRITIS & RHEUMATOLOGY . vol. 68 ,
Eldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J et al. ( 2016 ) . Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo . Annals of the Rheumatic Diseases vol. 75 , ( 6 ) 1228 - 1235 .
Lin NY, Distler A, Beyer C, Philipi-Schöbinger A, Stock M, Niemeier A, Dell'Accio F, Schett G et al. ( 2016 ) . OP0072 Inhibition of Notch1 Promotes Hedgehog Signaling in A HES1-Dependent Manner and Exacerbates Experimental Osteoarthritis . Annals of the Rheumatic Diseases . vol. 75 ,
Wei W, Bastiaansen-Jenniskens YM, Suijkerbuijk M, Kops N, Bos PK, Verhaar JAN, Zuurmond A-M, Dell'Accio F et al. ( 2016 ) . High fat diet accelerates cartilage repair in DBA/1 mice . Journal of Orthopaedic Research
nalesso, thomas, sherwood JC, Yu J, Addimanda O, Eldridge SE, Thorup, Dale L et al. ( 2016 ) . WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis . Annals of Rheumatic Diseases
Sherwood J, Bertrand J, Seidemann M, Dell''Accio F, Pap T ( 2016 ) . Activation of the Transient Receptor Potential Cation Channel TRPC6 is Required for Chondrocyte Phenotypic Stability . Osteoarthritis and Cartilage . Conference: 2016 OARSI World Congress on Osteoarthritis — Promoting Clinical and Basic Research in Osteoarthritis vol. 24 , S152 - S153 .
Eldridge SE, Petrycki E, Pitzalis C, Whiteford J, Dell'Accio F ( 2016 ) . MMP3 cleaves agrin in cartilage and reduces its chondrogenic potency . Osteoarthritis and Cartilage . vol. 24 ,
Nalesso G, Wagner K, Bertrand J, Sherwood JC, Thomas BL, Eldridge SE, Pitzalis C, Dell'Accio F ( 2016 ) . Pharmacological Blockade of CAMKII is Detrimental for Osteoarthritis Progression . Osteoarthritis and Cartilage . Conference: 2016 OARSI World Congress on Osteoarthritis vol. 24 (Suppl 1) , S149 - S149 .
Sherwood J, Bertrand J, Nalesso G, Poulet B, Pitsillides A, Brandolini L, Karystinou A, De Bari C et al. ( 2015 ) . A homeostatic function of CXCR2 signalling in articular cartilage . Ann Rheum Dis vol. 74 , ( 12 ) 2207 - 2215 .
Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A et al. ( 2015 ) . Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis . Science Translational Medicine vol. 7 , ( 315 )
Sherwood J, Bertrand J, Dell'Accio F, Pap T ( 2015 ) . The Role of TRPC6 in CXCR2-Mediated Chondrocyte Phenotypic Stability . ARTHRITIS & RHEUMATOLOGY . vol. 67 ,
Wei W, Bastiaansen-Jenniskens YM, Bos KP, Verhaar JA, Zuurmond A-M, Dell'Accio F, Van Osch GJ ( 2015 ) . Obesity does not negatively influence cartilage repair or cause osteoarthritis in DBA/1 mice . Osteoarthritis and Cartilage . vol. 23 ,
Clarke CK, Hansen U, Stange R, Echtermeyer F, Dell’Accio F, Pap T, Bertrand J ( 2015 ) . Syndecan-4 regulates chondrocyte extracellular matrix architecture and modulates WNT3A-induced matrix remodeling . Osteoarthritis and Cartilage . vol. 23 ,
Sherwood J, Bertrand J, Dell'Accio F, Pap T ( 2015 ) . TRPC6 plays a role in CXCR2-mediated chondrocyte phenotypic stability . Osteoarthritis and Cartilage . vol. 23 , a152 - a153 .
Driscoll C, Watt FE, Dell'Accio F, Vincent TL ( 2015 ) . The acute response to joint destabilisation is differentially regulated between male and female mice . Osteoarthritis and Cartilage . vol. 23 ,
Dell'Accio F, Sherwood J ( 2015 ) . PPARγ/mTOR signalling: Striking the right balance in cartilage homeostasis . Annals of the Rheumatic Diseases vol. 74 , ( 3 ) 477 - 479 .
Clarke C, Held A, Stange R, Nalesso G, Sherwood J, Hansen U, Godmann L, Echtermeyer F et al. ( 2015 ) . A4.11 Syndecan-4 is an important player in regulating the WNT signalling pathway in articular cartilage . Annals of the Rheumatic Diseases . vol. 74 , a40 - a41 .
Marcus P, De Bari C, Dell’Accio F, Archer CW ( 2014 ) . Articular Chondroprogenitor Cells Maintain Chondrogenic Potential but Fail to Form a Functional Matrix When Implanted Into Muscles of SCID Mice . Cartilage vol. 5 , ( 4 ) 231 - 240 .
Greco KV, Nalesso G, Kaneva MK, Sherwood J, Iqbal AJ, Moradi-Bidhendi N, Dell'Accio F, Perretti M ( 2014 ) . Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin . Biochem Pharmacol vol. 91 , ( 3 ) 348 - 358 .
Clarke CK, Held A, Stange R, Hansen U, Godmann L, Bertrand J, Pap T, Nalesso G et al. ( 2014 ) . Syndecan-4 Regulates Chondrocyte Phenotype and Cartilage Homeostasis Via the WNT Signaling Pathway . ARTHRITIS & RHEUMATOLOGY vol. 66 , S1289 - S1290 .
Sherwood JC, Bertrand J, Eldridge SE, Dell'Accio F ( 2014 ) . Cellular and molecular mechanisms of cartilage damage and repair . Drug Discov Today vol. 19 , ( 8 ) 1172 - 1177 .
Eldridge S, Vicente-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F ( 2014 ) . Agrin expression is downregulated in OA and is required for chondrocyte differentiation . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 95 , A8 - A9 .
Nalesso G, Thomas B, Wagner K, Bertrand J, Sherwood J, Eldridge S, Pap T, Achan P et al. ( 2014 ) . The WNT/CaMKII pathway is activated in human and experimental osteoarthritis and promotes chondrocyte de-differentiation . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 95 , A25 - A26 .
Headland S, Norling L, Patel H, Dalli J, Kelly S, Pitzalis C, Dell'Accio F, Perretti M ( 2014 ) . A novel mechanism for protecting the arthritic joint: microparticles deliver Annexin A1 into cartilage (146.8) . The FASEB Journal . vol. 28 ,
Nalesso G, Thomas BL, Sherwood J, Schett G, Dale L, Addimanda O, Eltawil N, Pitzalis C et al. ( 2014 ) . WNT16 IS INDUCED BY OXIDATIVE STRESS FOLLOWING CARTILAGE INJURY AND CONTRIBUTES TO CARTILAGE HOMEOSTASIS IN OSTEOARTHRITIS . OSTEOARTHRITIS AND CARTILAGE . vol. 22 , S8 - S9 .
Thomas BL, Nalesso G, Sherwood J, Bertrand J, Achan P, Pitzalis C, Dell'Accio F ( 2014 ) . WNT16 SUPPORTS THE PHENOTYPE OF THE SUPERFICIAL ZONE CELLS IN CARTILAGE . OSTEOARTHRITIS AND CARTILAGE . vol. 22 , S160 - S160 .
Heywood HK, Nalesso G, Lee DA, Dell'accio F ( 2014 ) . Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture . Biores Open Access vol. 3 , ( 1 ) 9 - 18 .
Sherwood J, Nalesso G, Bertrand J, Achan P, Brandolini L, Pap T, Pitzalis C, Dell'Accio F ( 2013 ) . A NOVEL ROLE FOR ELR plus CXC CHEMOKINE SIGNALING IN CARTILAGE HOMEOSTASIS . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , 161 - 161 .
Eldridge S, Vicent-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F ( 2013 ) . Agrin expression is downregulated in OA and is required for chondrocyte differentiation . Osteoarthritis and Cartilage vol. 21 , s112 - s113 .
Headland SE, Dell'Accio F, Perretti M ( 2013 ) . Neutrophil-Derived Microparticles as Novel Effectors in Joint Disease . FASEB JOURNAL . vol. 27 ,
Bertrand J, Stange R, Nalesso G, Sherwood J, Godmann L, Echtermeyer F, Dell'Accio F, Pap T ( 2013 ) . SYNDECAN-4 DEFICIENT CHONDROCYTES EXHIBIT ALTERATIONS IN ACTIVATION OF WNT SIGNALING PATHWAYS LEADING TO HIGHER PHENOTYPIC STABILITY . OSTEOARTHRITIS AND CARTILAGE . Conference: World Congress of the Osteoarthritis-Research-Society-International (OARSI) ( Philadelphia, PA ) from: 18/04/2013 to: 21/04/2013 , vol. 21 , S19 - S19 .
Dell'Accio F ( 2013 ) . TARGETING WNT SIGNALLING IN OSTEOARTHRITIS . RHEUMATOLOGY . Conference: Annual Meeting of the British-Society-for-Rheumatology and British-Health-Professionals-in-Rheumatology ( Birmingham, ENGLAND ) from: 23/04/2013 to: 25/04/2013 , vol. 52 , 22 - 22 .
Sherwood J, Bertrand J, Nalesso G, Achan P, Pitzalis C, Pap T, Dell'Accio F ( 2013 ) . THE ROLE OF CXCR2 SIGNALING IN ARTICULAR CARTILAGE HOMEOSTASIS . OSTEOARTHRITIS AND CARTILAGE . vol. 21 , S19 - S20 .
Nalesso G, Thomas BL, Eldridge SE, Wagner K, Sherwood J, Bertrand J, Pap T, Pitzalis C et al. ( 2013 ) . WNT5A/CAMKII PATHWAY IS ACTIVATED IN OSTEOARTHRITIS AND PROMOTES LOSS OF CHONDROCYTE PHENOTYPE . OSTEOARTHRITIS AND CARTILAGE . vol. 21 , S226 - S226 .
Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, Timmen M, Bruckner P et al. ( 2013 ) . SYNDECAN-4 FUNCTION IS ESSENTIAL FOR MATRIX REMODELLING UNDER INFLAMMATORY CONDITIONS, BUT DISPENSABLE DURING EMBRYOGENESIS . ANNALS OF THE RHEUMATIC DISEASES . Conference: 33rd European Workshop for Rheumatology Research ( Prague ) from: 28/02/2013 to: 02/03/2013 , vol. 72 , A61 - A62 .
Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, Timmen M, Bruckner P et al. ( 2013 ) . Syndecan 4 supports bone fracture repair, but not fetal skeletal development, in mice . Arthritis Rheum vol. 65 , ( 3 ) 743 - 752 .
Sherwood J, Bertrand J, Nalesso G, Achan P, Pitzalis C, Pap T, Dell'Accio F ( 2013 ) . THE ROLE OF CXCR2 SIGNALLING IN ARTICULAR CARTILAGE HOMEOSTASIS . ANNALS OF THE RHEUMATIC DISEASES . vol. 72 , A63 - A64 .
Sherwood J, Nalesso G, Bertrand J, Brandolini L, Achan P, Pitzalis C, Pap T, Dell'Accio F ( 2013 ) . A homoeostatic role for ELR plus CXC chemokine signalling in articular and epiphyseal cartilage . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 94 , A7 - A8 .
Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, dell'Accio F, Pap T et al. ( 2013 ) . Influences of Syndecan-2 and 4 on bone fracture repair and foetal skeletal development . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 94 , A8 - A8 .
Vincent TL, Williams RO, Maciewicz R, Silman A, Garside P, Arthritis Research UK animal models working group ( 2012 ) . Mapping pathogenesis of arthritis through small animal models . Rheumatology (Oxford) vol. 51 , ( 11 ) 1931 - 1941 .
Lin N-Y, Distler A, Beyer C, Dees C, Huang J, Dell'Accio F, Distler O, Schett GA et al. ( 2012 ) . Inhibition of Notch Signaling Increases the Severity of Experimental Osteoarthritis . ARTHRITIS AND RHEUMATISM . vol. 64 , S1062 - S1063 .
Bertrand J, Stange R, Nalesso G, Sherwood J, Godmann L, Echtermeyer F, Dell'Accio F, Pap T ( 2012 ) . Syndecan-4 Regulates Activation of WNT Signaling in Chondrocytes . ARTHRITIS AND RHEUMATISM . vol. 64 , S15 - S16 .
Sherwood J, Nalesso G, Bertrand J, Pap T, Achan P, Pitzalis C, Dell'Accio F ( 2012 ) . ELR plus CXC chemokine signaling is required for phenotypic stability of human articular chondrocytes . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 93 , A6 - A7 .
Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, Dell'Accio F ( 2012 ) . WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 93 , A8 - A8 .
Bertrand J, Nitschke Y, Fuerst M, Hermann S, Schäfers M, Sherwood J, Nalesso G, Ruether W et al. ( 2012 ) . Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice . Ann Rheum Dis vol. 71 , ( 7 ) 1249 - 1253 .
Sherwood J, Nalesso G, Bertrand J, Achan P, Brandolini L, Pap T, Pitzalis C, Dell'Accio F ( 2012 ) . ELR plus CXC CHEMOKINE SIGNALLING IN CARTILAGE HOMEOSTASIS . OSTEOARTHRITIS AND CARTILAGE . vol. 20 , S116 - S116 .
Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, Dell'Accio F, Pap T et al. ( 2012 ) . SYNDECAN-4 IS CRITICALLY INVOLVED IN INFLAMMATORY DRIVEN BONE FRACTURE REPAIR, BUT NOT FETAL SKELETAL DEVELOPMENT . OSTEOARTHRITIS AND CARTILAGE . vol. 20 , S25 - S26 .
Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, Dell'Accio F, Pap T et al. ( 2012 ) . BONE FRACTURE REPAIR, BUT NOT FETAL SKELETAL DEVELOPMENT IS SUPPORTED BY SYNDECAN-4 . ANNALS OF THE RHEUMATIC DISEASES . vol. 71 ,
Sherwood J, Nalesso G, Bertrand J, Pap T, Achan P, Pitzalis C, Dell'Accio F ( 2012 ) . ELR plus CXC CHEMOKINE SIGNALLING IN ARTICULAR CHONDROCYTE PHENOTYPIC STABILITY . ANNALS OF THE RHEUMATIC DISEASES . vol. 71 , A63 - U350 .
Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Eltawil NM, Amarrelli A, Al-Kashi A et al. ( 2012 ) . Targeting therapeutics to arthritic joints by antibody specific to post-translationally modified collagen type II . Annals of the Rheumatic Diseases . vol. 71 ,
Greco KV, Iqbal AJ, Rattazzi L, Nalesso G, Moradi-Bidhendi N, Moore AR, Goldring MB, Dell'Accio F et al. ( 2011 ) . High density micromass cultures of a human chondrocyte cell line: a reliable assay system to reveal the modulatory functions of pharmacological agents . Biochem Pharmacol vol. 82 , ( 12 ) 1919 - 1929 .
Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Al-Kashi A, Winyard P, Chernajovsky Y et al. ( 2011 ) . Targeting therapeutics to arthritic joints . IMMUNOLOGY . vol. 135 , 189 - 189 .
Bertrand J, Nitschke Y, Fuerst M, Ruether W, Rutsch F, Nalesso G, Dell'Accio F, Pap T ( 2011 ) . CYTOKINES DOWNREGULATE NPP1 AND THEREFORE INDUCE CARTILAGE MINERALIZATION IN OA . OSTEOARTHRITIS AND CARTILAGE vol. 19 , S99 - S99 .
Greco KV, Moore A, Dell'Accio F, Perretti M ( 2011 ) . 3D CULTURES OF C-28/I2 CHONDROCYTES TO STUDY CHONDROCYTE BIOLOGY AND THERAPEUTIC DEVELOPMENT . INFLAMMATION RESEARCH . vol. 60 , 283 - 283 .
Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, Dell'accio F ( 2011 ) . WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways . J Cell Biol vol. 193 , ( 3 ) 551 - 564 .
Kurth TB, Dell'accio F, Crouch V, Augello A, Sharpe PT, De Bari C ( 2011 ) . Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo . Arthritis Rheum vol. 63 , ( 5 ) 1289 - 1300 .
Pringle S, De Bari C, Dell'Accio F, Przyborski S, Cooke MJ, Minger SL, Grigoriadis AE ( 2011 ) . Mesenchymal differentiation propensity of a human embryonic stem cell line . Cell Prolif vol. 44 , ( 2 ) 120 - 127 .
Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Eltawil N, Marrelli A, Gould D et al. ( 2011 ) . TARGETING THERAPEUTICS TO ARTHRITIC JOINTS . RHEUMATOLOGY . vol. 50 , 127 - 127 .
Nalesso G, Sherwood J, Ramachandran M, De Bari C, Pitzalis C, Dell'Accio F ( 2011 ) . WNT3A MODULATES CHONDROCYTE PHENOTYPE THROUGH ACTIVATION OF BOTH CANONICAL AND NON-CANONICAL PATHWAYS . RHEUMATOLOGY . vol. 50 , 77 - 77 .
Nalesso G, Sherwood J, Ramachandran M, De Bari C, Pitzalis C, Dell'Accio F ( 2011 ) . Biology of bone, cartilage and connectve tissue disease92. WNT3A Modulates Chondrocyte Phenotype through Activation of both Canonical and Non-Canonical Pathways . Rheumatology vol. 50 , ( suppl_3 ) iii77 - iii77 .
Bertrand J, Furst M, Ruther W, Rutsch F, Nitschke Y, Dell'Accio F, Pap T ( 2011 ) . LOSS OF NPP1 INDUCES CARTILAGE REMODELLING INTO BONE AND OA-LIKE CHANGES IN MICE . ANNALS OF THE RHEUMATIC DISEASES . vol. 70 , A18 - A18 .
Kurth TB, Dell'accio F, Crouch V, Augello A, Sharpe PT, De Bari C ( 2011 ) . Functional mesenchymal stem cell niches in the adult knee joint synovium in vivo . Arthritis Rheum
Sherwood J, Key S, Achan P, Nalesso G, Pitzalis C, Dell'Accio F ( 2010 ) . CXCR1 AND CXCR2 SIGNALLING IS REQUIRED BUT IS NOT SUFFICIENT TO MAINTAIN THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES . OSTEOARTHRITIS AND CARTILAGE . vol. 18 , S96 - S96 .
Nalesso G, Achan P, Pitzalis C, Dell'Accio F ( 2010 ) . WNT3A MODULATES CHONDROCYTE PHENOTYPE THROUGH ACTIVATION OF BOTH CANONICAL AND NON-CANONICAL PATHWAYS . OSTEOARTHRITIS AND CARTILAGE . vol. 18 , S104 - S105 .
Dell'accio F, Vincent TL ( 2010 ) . Joint surface defects: clinical course and cellular response in spontaneous and experimental lesions . Eur Cell Mater vol. 20 , 210 - 217 .
Sherwood JC, Achan P, Ramachandran M, Pitzalis C, Dell'Accio F ( 2010 ) . CXCR1/2 SIGNALLING IS REQUIRED FOR THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES . RHEUMATOLOGY . vol. 49 , I13 - I13 .
Sherwood JC, Pitzalis C, Dell'Accio F ( 2010 ) . CXCR1/2 signalling in the phenotypic stability of in vitro expanded adult human articular chondrocytes . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 91 , A40 - A40 .
Nalesso G, Eltawil NM, Pitzalis C, Dell'Accio F ( 2010 ) . Effects of the modulation of Wnt-canonical pathway on the phenotypic stability of human articular chondrocytes . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 91 , A40 - A41 .
Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Eltawil N, Marrelli A, Gould D et al. ( 2010 ) . Human single-chain variable fragment that specifically targets arthritic cartilage . Arthritis Rheum vol. 62 , ( 4 ) 1007 - 1016 .
Eltawil N, Pitzalis C, Dell'Accio F ( 2010 ) . Molecular response of articular cartilage to injury: Wnt signaling in an in vivo model of joint surface injury . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 91 , A29 - A29 .
Gillespie J, Savic S, Wong C, Emery P, Grigg R, McDermott MF, Goodall JC, Wu C et al. ( 2010 ) . Concurrent Oral 4 – Basic Science [OP24–OP31]OP24. Hdac Activity: A Therapeutic Target in Rheumatoid Arthritis? . Rheumatology vol. 49 , ( suppl_1 ) i11 - i13 .
Dell'Accio F ( 2010 ) . Molecular mechanisms of cartilage regeneration . European Cells and Materials . vol. 20 ,
Dell'accio F, Vincent TL ( 2010 ) . Understanding tissue response to cartilage injury . Regenerative Medicine and Biomaterials for the Repair of Connective Tissues ,
Karystinou A, Dell'Accio F, Kurth TBA, Wackerhage H, Khan IM, Archer CW, Jones EA, Mitsiadis TA et al. ( 2009 ) . Distinct mesenchymal progenitor cell subsets in the adult human synovium . Rheumatology (Oxford) vol. 48 , ( 9 ) 1057 - 1064 .
Eltawil NM, De Bari C, Achan P, Pitzalis C, Dell'accio F ( 2009 ) . A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury . Osteoarthritis Cartilage vol. 17 , ( 6 ) 695 - 704 .
Dell'Accio F, Eltawil NM, De Bari C, Pitzalis C ( 2009 ) . WNT16 in joint surface injury and osteoarthritis . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 90 , A84 - A84 .
Guillot PV, De Bari C, Dell'Accio F, Kurata H, Polak J, Fisk NM ( 2008 ) . Comparative osteogenic transcription profiling of various fetal and adult mesenchymal stem cell sources . DIFFERENTIATION vol. 76 , ( 9 ) 946 - 957 .
Manzo A, Vitolo B, Humby F, Caporali R, Jarrossay D, Dell'Accio F, Ciardelli L, Uguccioni M et al. ( 2008 ) . Mature Antigen-Experienced T Helper Cells Synthesize and Secrete the B Cell Chemoattractant CXCL13 in the Inflammatory Environment of the Rheumatoid Joint . ARTHRITIS RHEUM vol. 58 , ( 11 ) 3377 - 3387 .
El Tawil NM, De Bari C, Pitzalis C, Dell'Accio F ( 2008 ) . A mouse model of joint surface injury and repair in mice. Age and strain-dependent outcome . ARTHRITIS AND RHEUMATISM . vol. 58 , S647 - S647 .
Dell'Accio F, De Bari C, Eltawil NA, Vanhummelen P, Pitzalis C ( 2008 ) . Identification of the molecular response of articular cartilage to injury, by microarray screening . ARTHRITIS RHEUM vol. 58 , ( 5 ) 1410 - 1421 .
Dell'Accio F, Eltawil NM, De Bari C, Pitzalis C ( 2008 ) . Wnt16 in joint surface injury and osteoarthritis . RHEUMATOLOGY . vol. 47 , II177 - II178 .
De BC, Dell'accio F, Karystinou A, Guillot PV, Fisk NM, Jones EA, McGonagle D, Khan IM et al. ( 2008 ) . A biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells . Arthritis Rheum. vol. 58 , ( 1 ) 240 - 250 .
De Bari C, Dell'Accio F, Karystinou A, Guillot PV, Fisk NM, Jones EA, McGonagle D, Khan IM et al. ( 2008 ) . A biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells . Arthritis Rheum vol. 58 , ( 1 ) 240 - 250 .
De Bari C, Dell'accio F ( 2008 ) . Cell therapy: a challenge in modern medicine . Biomed Mater Eng vol. 18 , ( 1 Suppl ) S11 - S17 .
De Bari C, Dell'Accio F ( 2007 ) . Mesenchymal stem cells in rheumatology: a regenerative approach to joint repair . CLIN SCI vol. 113 , ( 7-8 ) 339 - 348 .
de Bari C, Guillot PV, Fisk NM, Jones EA, McGonagle D, Khan IM, Archer CW, Mitsiadis TA et al. ( 2007 ) . Mathematical modeling to predict bone forming potency of human mesenchymal stem cells . European Cells and Materials . vol. 14 ,
De Bari C, Pitzalis C, Dell'Accio F ( 2007 ) . Joint tissue engineering . Stem Cell Repair and Regeneration, Volume 2 ,
De Bari C, Pringle S, Pitzalis C, Dell'Accio F ( 2006 ) . The stem cell niche: A new target in medicine . Current Opinion in Orthopaedics vol. 17 , ( 5 ) 398 - 404 .
DELL'ACCIO F, Pitzalis C, Barone F, Mitsiadis T, De Bari C ( 2006 ) . Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury . Arthritis Research & Therapy vol. 8 , ( 5 ) R139 - R139 .
Marcus P, de Bari C, Dell'Accio F, Dowthwaite G, Archer CW ( 2006 ) . The in vivo fate of implanted chondroprogenitor cells in SCID mice . European Cells and Materials . vol. 12 ,
Van Damme A, Thorrez L, Ma L, Vandenburgh H, Eyckmans J, Dell'Accio F, De Bari C, Luyten F et al. ( 2006 ) . Efficient lentiviral transduction and improved engraftment of human bone marrow mesenchymal cells . Stem Cells vol. 24 , ( 4 ) 896 - 907 .
De Bari C, Dell'Accio F, Vanlauwe J, Eyckmans J, Khan IM, Archer CW, Jones EA, McGonagle D et al. ( 2006 ) . Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis . Arthritis Rheum vol. 54 , ( 4 ) 1209 - 1221 .
De Bari C, Pitzalis C, Dell'Accio F ( 2006 ) . Reparative medicine: from tissue engineering to joint surface regeneration . Regen Med vol. 1 , ( 1 ) 59 - 69 .
De Bari C, Dell'Accio F, Vanlauwe J, Pitzalis C, Luyten FP ( 2005 ) . Distinct biological properties of human mesenchymal stem cells from different sources . Arthritis research & therapy vol. 7 , ( Suppl 1 ) P107 - P107 .
Dell'Accio F, De Bari C, Pitzalis C ( 2005 ) . Molecular response to cartilage injury . Arthritis research & therapy vol. 7 , ( Suppl 1 ) P131 - P131 .
De Bari C, Dell'Accio F, Luyten FP ( 2004 ) . Failure of in vitro-differentiated mesenchymal stem cells from the synovial membrane to form ectopic stable cartilage in vivo . Arthritis Rheum vol. 50 , ( 1 ) 142 - 150 .
DELL'ACCIO F, Luyten FP, De Bari C ( 2003 ) . Microenvironment and phenotypic stability specify tissue formation by human articular cartilage-derived cells in vivo . Experimental Cell Research vol. 287 , ( 1 ) 16 - 27 .
Van Damme A, Chuah MKL, Dell'Accio F, De Bari C, Luyten F, Collen D, Vandendriessche T ( 2003 ) . Erratum: Bone marrow mesenchymal cells for haemophilia. A gene therapy using retroviral vectors with modified long-terminal repeats (Haemophilia (2003) vol 9 (94-103)) . Haemophilia vol. 9 , ( 3 )
Vandenabeele F, De Bari C, Moreels M, Lambrichts I, Dell'Accio F, Lippens PL, Luyten FP ( 2003 ) . Morphological and immunocytochemical characterization of cultured fibroblast-like cells derived from adult human synovial membrane . Arch Histol Cytol vol. 66 , ( 2 ) 145 - 153 .
De Bari C, Dell'Accio F, Vandenabeele F, Vermeesch JR, Raymackers J-M, Luyten FP ( 2003 ) . Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane . J Cell Biol vol. 160 , ( 6 ) 909 - 918 .
Van Damme A, Chuah MKL, Dell'accio F, De Bari C, Luyten F, Collen D, VandenDriessche T ( 2003 ) . Bone marrow mesenchymal cells for haemophilia A gene therapy using retroviral vectors with modified long-terminal repeats . Haemophilia vol. 9 , ( 1 ) 94 - 103 .
Dell'Accio F, Vanlauwe J, Bellemans J, Neys J, De Beri C, Luyten FP ( 2003 ) . Erratum: "Expanded phenotypically stable chondrocytes persist in the repair tissue and contribute to cartilage matrix formation and structural integration in a goat model of autologous chondrocyte implantation" (Journal of Orthopaedic Research (2003) vol. 21 (1) (123-131) (S0736026602000906)) . Journal of Orthopaedic Research vol. 21 , ( 3 )
DELL'ACCIO F, Vanlauwe J, De Bari C, Neys J, Bellemans J, Luyten F ( 2003 ) . Expanded phenotypically stable chondrocytes persist in the repair tissue and contribute to cartilage matrix formation and structural integration in a goat model of autologous chondrocyte implantation . Journal of Orthopaedic Research vol. 21 , ( 1 ) 123 - 131 .
Iannone F, De Bari C, Dell'Accio F, Covelli M, Patella V, Lo Bianco G, Lapadula G ( 2002 ) . Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes . Rheumatology (Oxford) vol. 41 , ( 12 ) 1413 - 1418 .
Luyten FP, Dell'Accio F, De Bari C ( 2001 ) . Skeletal tissue engineering: opportunities and challenges . Best Pract Res Clin Rheumatol vol. 15 , ( 5 ) 759 - 769 .
De Bari C, Dell'Accio F, Tylzanowski P, Luyten FP ( 2001 ) . Multipotent mesenchymal stem cells from adult human synovial membrane . Arthritis Rheum vol. 44 , ( 8 ) 1928 - 1942 .
DELL'ACCIO F, Luyten FP, De Bari C ( 2001 ) . Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo . Arthritis & Rheumatism vol. 44 , ( 7 ) 1608 - 1619 .
Iannone F, De Bari C, Dell'Accio F, Covelli M, Cantatore FP, Patella V, Lo Bianco G, Lapadula G ( 2001 ) . Interleukin-10 and interleukin-10 receptor in human osteoarthritic and healthy chondrocytes . Clin Exp Rheumatol vol. 19 , ( 2 ) 139 - 145 .
De Bari C, Dell'Accio F, Luyten FP ( 2001 ) . Human periosteum-derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age . Arthritis Rheum vol. 44 , ( 1 ) 85 - 95 .
Cantatore FP, Dell'Accio F, Lapadula G ( 1997 ) . Carpal tunnel syndrome: a review . Clin Rheumatol vol. 16 , ( 6 ) 596 - 603 .
Lapadula G, De Bari C, Acquista CA, Dell'Accio F, Covelli M, Iannone F ( 1997 ) . Isolated thrombocytopenia associated with low dose methotrexate therapy . Clin Rheumatol vol. 16 , ( 4 ) 429 - 430 .
Lapadula G, Iannone F, Dell'Accio F, Covelli M, Pipitone V ( 1995 ) . Interleukin-10 in rheumatoid arthritis . Clin Exp Rheumatol vol. 13 , ( 5 ) 629 - 632 .