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Research

Publications: Prof Claude Chelala

Sivapalan L, Kocher HM, Ross-Adams H, Chelala C ( 2021 ) . Molecular profiling of ctDNA in pancreatic cancer: Opportunities and challenges for clinical application . Pancreatology vol. 21 , ( 2 ) 363 - 378 .
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al. ( 2020 ) . Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer . NPJ Breast Cancer vol. 6 , ( 1 )
Montero Melendez T, Nagano A, Chelala C, Filer A, Buckley CD, Perretti M ( 2020 ) . Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis . Nature Communications vol. 11 , ( 1 ) Article 745 ,
Lu S, Zhang Z, Du P, Chard LS, Yan W, Khouri ME, Wang Z, Zhang Z et al. ( 2020 ) . A virus-infected, reprogrammed somatic cell–derived tumor cell (VIREST) vaccination regime can prevent initiation and progression of pancreatic cancer . Clinical Cancer Research vol. 26 , ( 2 ) 465 - 476 .
Pirrò S, Spada F, Gadaleta E, Ferrentino F, Thorn GJ, Cesareni G, Chelala C ( 2019 ) . HiPPO and PANDA: Two Bioinformatics Tools to Support Analysis of Mass Cytometry Data . J Comput Biol
Pirrò S, Gadaleta E, Galgani A, Colizzi V, Chelala C ( 2019 ) . SMAC, a computational system to link literature, biomedical and expression data . Scientific Reports vol. 9 , ( 1 )
Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB et al. ( 2019 ) . The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy . Journal of Pathology vol. 249 , ( 3 ) 332 - 342 .
Martin S ( 2019 ) . MLH1 deficiency leads to deregulated mitochondrial metabolism . Cell Death and Disease vol. 10 , 795 - 795 .
Barry S, Carlsen E, Marques P, Stiles CE, Gadaleta E, Berney DM, Roncaroli F, Chelala C et al. ( 2019 ) . Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors . Oncogene vol. 38 , ( 27 ) 5381 - 5395 .
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al. ( 2019 ) . Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma (Leukemia, (2018), 32, 5, (1261-1265), 10.1038/s41375-018-0043-y) . Leukemia vol. 33 , ( 6 )
Allen N, Allen M, Ahmed K, Gomm J, Nelan R, Nagano A, Chelala C, Gadaleta E et al. ( 2019 ) . Defining molecular signatures to personalise management of patients with early breast cancer . CANCER RESEARCH . Conference: 2018 San Antonio Breast Cancer Symposium from: 04/12/2019 to: 08/12/2019 , vol. 79 ,
Bladen JC, Wang J, Sangaralingam A, Moosajee M, Fitchett C, Chelala C, Beaconsfield M, O'Toole EA et al. ( 2018 ) . MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma . Scientific Reports vol. 8 , ( 1 )
Inman GJ, Wang J, Nagano A, Alexandrov LB, Purdie KJ, Taylor RG, Sherwood V, Thomson J et al. ( 2018 ) . The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature . Nature Communications vol. 9 , ( 1 )
Arnandis T, Monteiro P, Adams SD, Bridgeman VL, Rajeeve V, Gadaleta E, Marzec J, Chelala C et al. ( 2018 ) . Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion . Developmental Cell vol. 47 , ( 4 ) 409 - 424.e9 .
Dayem Ullah AZ, Oscanoa J, Wang J, Nagano A, Lemoine NR, Chelala C ( 2018 ) . SNPnexus: Assessing the functional relevance of genetic variation to facilitate the promise of precision medicine . Nucleic Acids Research vol. 46 , ( W1 ) W109 - W113 .
Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A et al. ( 2018 ) . A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia . EMBO Mol Med
Wang J, Dayem Ullah AZ, Chelala C ( 2018 ) . IW-Scoring: an Integrative Weighted Scoring framework for annotating and prioritizing genetic variations in the noncoding genome . Nucleic acids research vol. 46 , ( 8 )
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al. ( 2018 ) . Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma . Leukemia vol. 32 , ( 5 ) 1258 - 1263 .
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y et al. ( 2018 ) . PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer . Cell Reports vol. 22 , ( 9 ) 2469 - 2481 .
WANG Y, Dayem Ullah AZ, Chelala C ( 2018 ) . IW-Scoring: an Integrative Weighted Scoring framework for annotating and prioritising genetic variations in the noncoding genome. Nucleic Acids Research . Nucleic Acids Research vol. 46 , ( 8 ) e47 - e47 .
Gadaleta E, Pirrò S, Dayem Ullah AZ, Marzec J, Chelala C ( 2018 ) . BCNTB bioinformatics: The next evolutionary step in the bioinformatics of breast cancer tissue banking . Nucleic Acids Research vol. 46 , ( D1 ) D1055 - D1061 .
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward JA et al. ( 2017 ) . Genomic Profiling Reveals Spatial Intra-Tumor Heterogeneity in Follicular Lymphoma . BLOOD . vol. 130 ,
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al. ( 2017 ) . Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers . Cancer Discov
Wang J, Dumartin L, Mafficini A, Ulug P, Sangaralingam A, Alamiry NA, Radon TP, Salvia R et al. ( 2017 ) . Splice variants as novel targets in pancreatic ductal adenocarcinoma . Scientific Reports vol. 7 , ( 1 )
Marzec J, Dayem Ullah AZ, Pirrò S, Gadaleta E, Crnogorac-Jurcevic T, Lemoine NR, Kocher HM, Chelala C ( 2017 ) . The Pancreatic Expression Database: 2018 update . Nucleic Acids Res vol. 46 , ( D1 ) D1107 - D1110 .
Sangaralingam A, Dayem Ullah AZ, Marzec J, Gadaleta E, Nagano A, Ross-Adams H, Wang J, Lemoine NR et al. ( 2017 ) . 'Multi-omic' data analysis using O-miner . Brief Bioinform
Tawana K, Wang J, Király PA, Kállay K, Benyó G, Zombori M, Csomor J, Al Seraihi A et al. ( 2017 ) . Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree . European Journal of Human Genetics vol. 25 , ( 8 ) 1020 - 1024 .
Chupin J, Nagano A, Haley V, Lenihan C, Cavicchioli F, O¿Leary K, Sahgal N, Nigro CL et al. ( 2017 ) . Abstract 104: miRNAs in the 14q32 cluster are involved in lapatinib resistance . 104 - 104 .
Harwood C, Proby C, Wang J, Nagano A, Alexandrov L, Purdie K, Chelala C, Inman G et al. ( 2017 ) . Chronic azathioprine treatment is causal in cutaneous squamous cell carcinoma development and is associated with a novel mutational signature . BRITISH JOURNAL OF DERMATOLOGY . vol. 177 , 9 - 10 .
Thomson J, Wang A, Nagano A, Chelala C, Purdie K, Har C, Proby C, Inman G et al. ( 2017 ) . Understanding actinic keratosis and squamous cell carcinoma in the era of whole-exome and -genome sequencing . BRITISH JOURNAL OF DERMATOLOGY . vol. 177 , 15 - 16 .
Besley C, Kotsiou E, Petty R, Sangaralingam A, Chelala C, Ghazaly E, LeDieu R, Gribben J et al. ( 2017 ) . ALLORESPONSES OF HUMAN T-CELLS FROM ADULT PERIPHERAL BLOOD AND UMBILICAL CORD BLOOD ARE DIFFERENTIALLY IMPACTED BY LENALIDOMIDE - IMPLICATIONS FOR AHSCT . HAEMATOLOGICA . vol. 102 , 638 - 638 .
Ironside A, Hawkesford K, Gomm J, Haywood L, Goulding I, Wang J, Lamaziere A, Poirot M et al. ( 2017 ) . Molecular mediators of mammographic density . CANCER RESEARCH . Conference: 2016 San Antonio Breast Cancer Symposium from: 06/12/2016 to: 10/12/2016 , vol. 77 ,
Morrissey B, Blyth K, Carter P, Chelala C, Jones L, Holen I, Speirs V ( 2017 ) . The Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) Framework: Encouraging Reduction, Replacement, and Refinement in Animal Research . PLoS Biol vol. 15 , ( 1 ) e2000719 - e2000719 .
Moniz LS, Surinova S, Ghazaly E, Velasco LG, Haider S, Rodríguez-Prados JC, Berenjeno IM, Chelala C et al. ( 2017 ) . Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate . Scientific Reports vol. 7 ,
Besley C, Kotsiou E, Petty R, Ajanthah S, Chelala C, Ghazaly E, Le Dieu R, Davies J et al. ( 2016 ) . Alloresponses of Human T-Cells from Adult Peripheral Blood and Umbilical Cord Blood Are Differentially Impacted By Lenalidomide . Blood . vol. 128 , 5714 - 5714 .
Makoukji J, Makhoul NJ, Khalil M, El-Sitt S, Aldin ES, Jabbour M, Boulos F, Gadaleta E et al. ( 2016 ) . Gene expression profiling of breast cancer in Lebanese women . Scientific Reports vol. 6 , 36639 - 36639 .
Ghayad SE, Rammal G, Ghamloush F, Basma H, Nasr R, Diab-Assaf M, Chelala C, Saab R ( 2016 ) . Exosomes derived from embryonal and alveolar rhabdomyosarcoma carry differential miRNA cargo and promote invasion of recipient fibroblasts . Scientific Reports vol. 6 , Article 37088 ,
Parker H, Rose-Zerilli MJJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J et al. ( 2016 ) . Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia . LEUKEMIA vol. 30 , ( 11 ) 2179 - 2186 .
Proby CM, Inman G, Wang JA, Nagano A, Purdie KJ, Gulati A, Lambert S, Mladkova N et al. ( 2016 ) . Characterisation of the molecular landscape of cutaneous squamous cell carcinoma and Identification of a novel mutational signature associated with chronic azathioprine exposure . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 58 - 59 .
Speirs V, Morrisey B, Holen I, Blyth K, Carter P, Chelala C, Jones L ( 2016 ) . SEARCHBreast: An online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals . Journal of Pathology vol. 240 , ( 1 ) 120 - 120 .
Mao X, Luo F, Boyd LK, Zhou B, Zhang Y, Stankiewicz E, Marzec J, Vasiljevic N et al. ( 2016 ) . NKAIN2 functions as a novel tumor suppressor in prostate cancer . Oncotarget
Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D et al. ( 2016 ) . Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma . Nature Communications vol. 7 , 12493 - 12493 .
Jones JL, Gomm J, Haywood L, Morgan A, Goulding I, Allen M, Chelala C, Gadelata E ( 2016 ) . Breast Cancer Now Cell Culture Programme: a bespoke resource for the research community . Breast Cancer Research and Treatment . Conference: UK Breast Cancer Research Symposium 2016 from: 22/07/2016 to: 23/07/2016 , vol. 159 , 196 - 196 .
Balarajah V, Ambily A, Dayem Ullah AZ, Imrali A, Dowe T, Al-Sarireh B, Abu Hilal M, Davidson BR et al. ( 2016 ) . Pancreatic cancer tissue banks: where are we heading? . Future Oncol vol. 12 , ( 23 ) 2661 - 2663 .
Locke M, Ghazaly E, Freitas MO, Mitsinga M, Lattanzio L, Lo Nigro C, Nagano A, Wang J et al. ( 2016 ) . Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1 . Cell Reports vol. 16 , ( 6 ) 1604 - 1613 .
Proby C, Inman G, Wang J, Nagano A, Purdie K, Mladkova N, Lambert S, Gulati A et al. ( 2016 ) . Characterisation of the molecular landscape of cutaneous squamous cell carcinoma . MELANOMA RESEARCH . vol. 26 , E69 - E69 .
Cammareri P, Rose A, Vincent D, Wang J, Nagano A, Libertini S, Ridgway R, Mchugh A et al. ( 2016 ) . Frequent loss of function mutations in TGF beta R1 and TGF beta R2 implicate hair follicle bulge stem cells as a cell of origin of cutaneous squamous cell carcinoma . MELANOMA RESEARCH . vol. 26 , E63 - E64 .
Inman G, Proby CM, Wang JA, Nagano A, Alexandrov L, Purdie K, Rose A, Weir L et al. ( 2016 ) . Identification of a novel mutational signature in cutaneous SCC associated with chronic azathioprine exposure . MELANOMA RESEARCH . vol. 26 , E114 - E115 .
Morrissey B, Blyth K, Carter P, Chelala C, Jones L, Holen I, Speirs V ( 2016 ) . SEARCHBreast; making surplus material from in vivo models of breast cancer available for research . EUROPEAN JOURNAL OF CANCER . vol. 61 , S198 - S198 .
Morrissey B, Holen I, Chelala C, Carter P, Jones L, Blyth K, Speirs V ( 2016 ) . Introducing SEARCHBreast: a virtual resource to facilitate sharing of surplus animal material developed for breast cancer research . NPJ Breast Cancer vol. 2 , 16020 - 16020 .
Parker H, Rose-Zerilli MJJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J et al. ( 2016 ) . Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia . Leukemia
GROSE RP, Dawkins JBN, Wang J, maniati, heward, koniali, kocher, martin et al. ( 2016 ) . Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma . Cancer Research
Araf S, Wang J, Pangault C, Kotsiou E, Hoxha E, Iqbal S, Davies J, Johnson P et al. ( 2016 ) . GENOMIC PROFILING REVEALS SPATIAL HETEROGENEITY IN FOLLICULAR LYMPHOMA: IMPLICATIONS FOR PRECISION MEDICINE . HAEMATOLOGICA . vol. 101 , 270 - 270 .
Rose-Zerilli MJJ, Gibson J, Wang J, Tapper W, Davis Z, Parker H, Larrayoz M, McCarthy H et al. ( 2016 ) . Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease . Leukemia vol. 30 , ( 6 ) 1301 - 1310 .
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al. ( 2016 ) . Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma (vol 48, pg 183, 2016) . NATURE GENETICS vol. 48 , ( 6 ) 700 - 700 .
Rio-Machin A, Cardoso S, Tawana K, Wang J, Chelala C, Plagnol V, Wallis Y, Ryan G et al. ( 2016 ) . WHOLE EXOME SEQUENCING REVEALS NOVEL CANDIDATE GENES IN FAMILIAL MDS/AML . HAEMATOLOGICA . vol. 101 , 205 - 206 .
Morrissey B, Blyth K, Carter P, Chelala C, Jones L, Holen I, Speirs V ( 2016 ) . SEARCHBreast: A new online resource to make surplus material from in vivo models of breast cancer visible and accessible to researchers . Breast Cancer Research vol. 18 , ( 1 )
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Seraihi AFA et al. ( 2016 ) . Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Nat Genet vol. 48 , ( 6 ) 700 - 700 .
Cammareri P, Rose A, Vincent D, Wang J, Nagano A, Coates P, Sapkota G, Purdie K et al. ( 2016 ) . Inactivation of transforming growth factor-beta receptors in human cutaneous squamous cell carcinoma and murine hair follicle stem cells drives tumorigenesis . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E51 - E52 .
Proby C, Inman G, Nagano A, Purdie K, Mladkova N, Alexandrov L, Stratton M, Watt S et al. ( 2016 ) . The molecular landscape of cutaneous squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E50 - E51 .
Marzec J, Mao X, Li M, Wang M, Feng N, Gou X, Wang G, Sun Z et al. ( 2016 ) . A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population . Oncotarget vol. 7 , ( 16 ) 21393 - 21403 .
Blyth K, Carter P, Morrissey B, Chelala C, Jones L, Holen I, Speirs V ( 2016 ) . SEARCHBreast: a new resource to locate and share surplus archival material from breast cancer animal models to help address the 3Rs . Breast Cancer Research and Treatment vol. 156 , ( 3 ) 447 - 452 .
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al. ( 2016 ) . Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Nature Genetics vol. 48 , ( 2 ) 183 - 188 .
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al. ( 2015 ) . Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Nature Genetics .
Morrissey B, Blyth K, Carter P, Chelala C, Holen I, Jones L, Speirs V ( 2015 ) . SEARCHBreast workshop proceedings: 3D modelling of breast cancer . ATLA Alternatives to Laboratory Animals vol. 43 , ( 6 ) 367 - 375 .
Tawana K, Wang J, Renneville A, Bödör C, Hills R, Loveday C, Savic A, Van Delft FW et al. ( 2015 ) . Disease evolution and outcomes in familial AML with germline CEBPA mutations . Blood vol. 126 , ( 10 ) 1214 - 1223 .
Speirs V, Blyth K, Carter P, Chelala C, Holen I, Jones L, Morrissey B ( 2015 ) . Animal research: Share surplus animal tissue . Nature vol. 522 , ( 7555 ) 156 - 156 .
Makoukji J, Raad M, Genadry K, El-Sitt S, Makhoul NJ, Aldin ES, Nohra E, Jabbour M et al. ( 2015 ) . Association between CLN3 (neuronal ceroid lipofuscinosis, CLN3 type) gene expression and clinical characteristics of breast cancer patients . Frontiers in Oncology vol. 5 , ( OCT )
Cutts RJ, Guerra-Assunção JA, Gadaleta E, Dayem Ullah AZ, Chelala C ( 2015 ) . BCCTBbp: the Breast Cancer Campaign Tissue Bank bioinformatics portal . Nucleic Acids Res vol. 43 , ( Database issue ) D831 - D836 .
Debernardi S, Massat NJ, Radon TP, Sangaralingam A, Banissi A, Ennis DP, Dowe T, Chelala C et al. ( 2015 ) . Noninvasive urinary miRNA biomarkers for early detection of pancreatic adenocarcinoma . American Journal of Cancer Research vol. 5 , ( 11 ) 3455 - 3466 .
Guillermet-Guibert J, Smith LB, Halet G, Whitehead MA, Pearce W, Rebourcet D, León K, Crépieux P et al. ( 2015 ) . Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells . PLoS Genetics vol. 11 , ( 7 )
Smedley D, Haider S, Durinck S, Pandini L, Provero P, Allen J, Arnaiz O, Awedh MH et al. ( 2015 ) . The BioMart community portal: An innovative alternative to large, centralized data repositories . Nucleic Acids Research vol. 43 , ( W1 ) W589 - W598 .
Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T et al. ( 2014 ) . A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma . Genome Medicine vol. 6 , ( 12 )
Ren G, Zhang Y, Mao X, Liu X, Mercer E, Marzec J, Ding D, Jiao Y et al. ( 2014 ) . Transcription-mediated chimeric RNAs in prostate cancer: time to revisit old hypothesis? . OMICS vol. 18 , ( 10 ) 615 - 624 .
Cutts R, Jithesh PV, Delage B, Luong P, Thomas G, Chelala C, Szlosarek PW ( 2014 ) . Abstract 1431: Gene expression analysis of argininosuccinate synthetase loss and the effects of pegylated arginine deiminase in malignant pleural mesothelioma . 1431 - 1431 .
Wong P-P, Yeoh CC, Ahmad AS, Chelala C, Gillett C, Speirs V, Jones JL, Hurst HC ( 2014 ) . Identification of MAGEA antigens as causal players in the development of tamoxifen-resistant breast cancer . Oncogene vol. 33 , ( 37 ) 4579 - 4588 .
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al. ( 2014 ) . Therapeutic targeting of integrin αvβ6 in breast cancer . J Natl Cancer Inst vol. 106 , ( 8 )
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevi¿ N, Chaplin T et al. ( 2014 ) . Identification of ZDHHC14 as a novel human tumour suppressor gene . J Pathol vol. 232 , ( 5 ) 566 - 577 .
Speirs V, Chelala C, Coates R, Jones JL, Matharoo-Ball B, Quinlan P ( 2014 ) . The Breast Cancer Campaign Tissue Bank: Generating new biomaterials to accelerate breast cancer research . EUROPEAN JOURNAL OF CANCER . vol. 50 , S200 - S200 .
Okosun J, Bödör C, Wang J, Araf S, Yang CY, Pan C, Boller S, Cittaro D et al. ( 2014 ) . Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma . Nature Genetics vol. 46 , ( 2 ) 176 - 181 .
Okosun J, Bödör C, Wang J, Araf S, Yang C-Y, Pan C, Boller S, Cittaro D et al. ( 2014 ) . Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma . Nat Genet vol. 46 , ( 2 ) 176 - 181 .
Allen MD, Luong P, Hudson C, Leyton J, Delage B, Ghazaly E, Cutts R, Yuan M et al. ( 2014 ) . Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging . Cancer Res vol. 74 , ( 3 ) 896 - 907 .
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevíc N, Chaplin T et al. ( 2014 ) . Erratum:Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol (2014); 232: 566-577)) . Journal of Pathology vol. 234 , ( 1 )
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Marzec J, Vasiljevic N, Chaplin T, Foster JM et al. ( 2014 ) . Identification of ZDHHC14 as a novel human tumour suppressor: gene . INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE vol. 34 , S90 - S90 .
Mao X, Marzec J, Li M, Zhang Z, Feng N, Gou X, Sun Z, Xu J et al. ( 2014 ) . Population differences in the genetic risk of prostate cancer and predisposition loci in the Chinese population . INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE vol. 34 , S89 - S89 .
Dayem Ullah AZ, Cutts RJ, Ghetia M, Gadaleta E, Hahn SA, Crnogorac-Jurcevic T, Lemoine NR, Chelala C ( 2014 ) . The pancreatic expression database: recent extensions and updates . Nucleic Acids Res vol. 42 , ( Database issue ) D944 - D949 .
Moore K, Thomas G, Duffy S, Warwick J, Gabe R, Chou P, Ellis I, Green A et al. ( 2013 ) . Abstract P4-15-01: Integrin avb6 is a therapeutic target for high-risk breast cancer and enhances trastuzumab efficacy .
Speirs V, Good R, Hanby A, Matharoo-Ball B, Thomson B, Ellis I, Quinlan P, Lyons D et al. ( 2013 ) . Abstract P4-19-02: Early experience of patient donation and researcher use of tissues donated to a national breast cancer tissue bank .
Tawana K, Renneville A, Wang J, Georgiades P, Thomas X, Mialou V, Savic A, Van Delft FW et al. ( 2013 ) . Familial AML With Germline CEBPA Mutations: Extended Clinical Outcomes and Analysis Of Secondary Mutations Using Whole Exome Sequencing . Blood . vol. 122 , 740 - 740 .
Popov N, Maniati E, Marzec J, Okosun J, Scott R, Kranz A, Stewart F, Chelala C et al. ( 2013 ) . Investigating The Role Of MLL2 (Mll4) In B Cell Development . Blood . vol. 122 , 343 - 343 .
Ene-Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin-Aleong J et al. ( 2013 ) . Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma . Gastroenterology vol. 145 , ( 5 ) 1121 - 1132 .
Bödör C, Grossmann V, Popov N, Okosun J, O'Riain C, Tan K, Marzec J, Araf S et al. ( 2013 ) . EZH2 mutations are frequent and represent an early event in follicular lymphoma . Blood vol. 122 , ( 18 ) 3165 - 3168 .
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al. ( 2013 ) . Abstract B046: Therapeutic targeting of integrin αvβ6 in high-risk breast cancer . b046 - b046 .
Gadaleta E, Cutts RJ, Sangaralingam A, Lemoine NR, Chelala C ( 2013 ) . An Integrated Systems Approach to the Study of Pancreatic Cancer . Systems Biology in Cancer Research and Drug Discovery ,
Dayem Ullah AZ, Lemoine NR, Chelala C ( 2013 ) . A practical guide for the functional annotation of genetic variations using SNPnexus . Brief Bioinform vol. 14 , ( 4 ) 437 - 447 .
Kadaba R, Birke H, Wang J, Hooper S, Andl CD, Di Maggio F, Soylu E, Ghallab M et al. ( 2013 ) . Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes . J Pathol vol. 230 , ( 1 ) 107 - 117 .
Milne R, La Vecchia C, Van Steen K, Hahn S, Buchholz M, Costello E, Esposito I, Hoheisel JD et al. ( 2013 ) . EU pancreas: An integrated european platform for pancreas cancer research - From basic science to clinical and public health interventions for a rare disease . Public Health Genomics vol. 16 , ( 6 ) 305 - 312 .
Barry S, Chelala C, Lines K, Sunamura M, Wang A, Marelli-Berg FM, Brennan C, Lemoine NR et al. ( 2013 ) . S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells . Clin Exp Metastasis vol. 30 , ( 3 ) 251 - 264 .
Crnogorac-Jurcevic T, Chelala C, Barry S, Harada T, Bhakta V, Lattimore S, Jurcevic S, Bronner M et al. ( 2013 ) . Molecular analysis of precursor lesions in familial pancreatic cancer . PLoS One vol. 8 , ( 1 )
Okosun J, Boedoer C, Wang J, Araf S, Marzec J, Iqbal S, Matthews J, Calaminici M et al. ( 2012 ) . Whole Genome Sequencing in Sequential Biopsies Reveals the Genetic Evolution of Follicular Lymphoma to Transformed Follicular Lymphoma . BLOOD . vol. 120 ,
Cutts RJ, Dayem Ullah AZ, Sangaralingam A, Gadaleta E, Lemoine NR, Chelala C ( 2012 ) . O-miner: an integrative platform for automated analysis and mining of -omics data . Nucleic Acids Res vol. 40 , ( Web Server issue ) W560 - W568 .
Dayem Ullah AZ, Lemoine NR, Chelala C ( 2012 ) . SNPnexus: a web server for functional annotation of novel and publicly known genetic variants (2012 update) . Nucleic Acids Res vol. 40 , ( Web Server issue ) W65 - W70 .
Lines KE, Chelala C, Dmitrovic B, Wijesuriya N, Kocher HM, Marshall JF, Crnogorac-Jurcevic T ( 2012 ) . S100P-binding protein, S100PBP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells . Am J Pathol vol. 180 , ( 4 ) 1485 - 1494 .
Gadaleta E, Cutts RJ, Kelly GP, Crnogorac-Jurcevic T, Kocher HM, Lemoine NR, Chelala C ( 2011 ) . A global insight into a cancer transcriptional space using pancreatic data: importance, findings and flaws . Nucleic Acids Res vol. 39 , ( 18 ) 7900 - 7907 .
Froeling FEM, Feig C, Chelala C, Dobson R, Mein CE, Tuveson DA, Clevers H, Hart IR et al. ( 2011 ) . Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression . Gastroenterology vol. 141 , ( 4 ) 1486 - 1497.14 .
Froeling F, Chelala C, Clevers H, Hart I, Kocher H ( 2011 ) . Retinoic Acid-Induced Stellate Cell Quiescence Results in Sfrp4 Secretion Which Abrogates Wnt-beta-Catenin Signalling Pathway Modulating Human Pancreatic Tumour Cell Behaviour . GASTROENTEROLOGY . vol. 140 , S156 - S157 .
Lines KE, Audi N, Chelala C, Wijesuriya N, Kocher H, Hurst H, Crnogorac-Jurcevic T ( 2011 ) . Abstract 1537: Role of S100PBP in pancreatic adenocarcinoma . 1537 - 1537 .
Allen MD, Vaziri R, Green M, Chelala C, Brentnall AR, Dreger S, Vallath S, Nitch-Smith H et al. ( 2011 ) . Clinical and functional significance of α9β1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion . J Pathol vol. 223 , ( 5 ) 646 - 658 .
Guberman JM, Ai J, Arnaiz O, Baran J, Blake A, Baldock R, Chelala C, Croft D et al. ( 2011 ) . BioMart Central Portal: an open database network for the biological community . Database (Oxford) vol. 2011 ,
Gadaleta E, Lemoine NR, Chelala C ( 2011 ) . Online resources of cancer data: barriers, benefits and lessons . Brief Bioinform vol. 12 , ( 1 ) 52 - 63 .
Cutts RJ, Gadaleta E, Hahn SA, Crnogorac-Jurcevic T, Lemoine NR, Chelala C ( 2011 ) . The Pancreatic Expression database: 2011 update . Nucleic Acids Res vol. 39 , ( Database issue ) D1023 - D1028 .
Cutts RJ, Gadaleta E, Lemoine NR, Chelala C ( 2011 ) . Using BioMart as a framework to manage and query pancreatic cancer data . Database (Oxford) vol. 2011 ,
Flak MB, Connell CM, Chelala C, Archibald K, Salako MA, Pirlo KJ, Lockley M, Wheatley SP et al. ( 2010 ) . p21 Promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker . Mol Cancer vol. 9 ,
An Q, Jones L, Tapper W, Chelala C, Iravani M, MacKay A, Hammond V, Durcan L et al. ( 2010 ) . A novel tumour-based test to identify breast cancer due to BRCA1 and BRCA2 mutations . BREAST CANCER RESEARCH . vol. 12 , S10 - S10 .
Eccles DM, An Q, Jones L, Tapper W, Chelala C, Iravani M, Mckay A, Hammond V et al. ( 2009 ) . A Novel Tumour-Based Test To Identify Breast Cancer Due to BRCA1 and BRCA2 Mutations . CANCER RESEARCH . vol. 69 , 775S - 775S .
Dawoud MM, Jones D, Hodivala-Dilke K, Dreger S, Chelala C, Asaad NY, Jones L ( 2009 ) . Microenvironmental Changes in DCIS: Myoepithelial Cells Change from Tumour Suppressor to Tumour Promoter . CANCER RESEARCH . vol. 69 , 760S - 760S .
Barry S, Chelala C, Sunamura M, Bhakta V, Lemoine NR, Jurcevic T ( 2009 ) . Search for Novel molecular targets in pancreatic cancer by comparative analysis of primary and metastatic disease . CLIN EXP METASTAS vol. 26 , ( 7 ) 856 - 856 .
Wang Y, Gangeswaran R, Zhao X, Wang P, Tysome J, Bhakta V, Yuan M, Chikkanna-Gowda CP et al. ( 2009 ) . CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells . J Clin Invest vol. 119 , ( 6 ) 1604 - 1615 .
Flak MB, Connell CM, Hill RM, Hallden G, Chelala C, McNeish IA ( 2009 ) . Critical Role for p21 and p27 in Efficacy of Oncolytic Adenovirus dl922-947 in Ovarian Cancer . MOLECULAR THERAPY . vol. 17 , S100 - S100 .
Chelala C, Khan A, Lemoine NR ( 2009 ) . SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms . Bioinformatics vol. 25 , ( 5 ) 655 - 661 .
Chelala C, Lemoine NR, Hahn SA, Crnogorac-Jurcevic T ( 2009 ) . A web-based platform for mining pancreatic expression datasets . Pancreatology vol. 9 , ( 4 ) 340 - 343 .
Harada T, Chelala C, Crnogorac-Jurcevic T, Lemoine NR ( 2009 ) . Genome-wide analysis of pancreatic cancer using microarray-based techniques . Pancreatology vol. 9 , ( 1-2 ) 13 - 24 .
Yuan M, Tomlinson V, Lara R, Holliday D, Chelala C, Harada T, Gangeswaran R, Manson-Bishop C et al. ( 2008 ) . Yes-associated protein (YAP) functions as a tumor suppressor in breast . Cell Death Differ vol. 15 , ( 11 ) 1752 - 1759 .
Flak MB, Connell CM, Hill RM, Hallden G, Chelala C, McNeish IA ( 2008 ) . Host cell factors in ovarian cancer influencing efficacy of oncolytic adenovirus dl922-947 . HUMAN GENE THERAPY . vol. 19 , 1083 - 1083 .
Gupta M, Raghavan M, Gale RE, Chelala C, Allen C, Molloy G, Chaplin T, Linch DC et al. ( 2008 ) . Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia . Genes Chromosomes Cancer vol. 47 , ( 9 ) 729 - 739 .
Raghavan M, Smith L-L, Lillington DM, Chaplin T, Kakkas I, Molloy G, Chelala C, Cazier J-B et al. ( 2008 ) . Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia . Blood vol. 112 , ( 3 ) 814 - 821 .
Harada T, Chelala C, Bhakta V, Chaplin T, Caulee K, Baril P, Young BD, Lemoine NR ( 2008 ) . Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays . Oncogene vol. 27 , ( 13 ) 1951 - 1960 .
Chelala C, Hahn SA, Whiteman HJ, Barry S, Hariharan D, Radon TP, Lemoine NR, Crnogorac-Jurcevic T ( 2007 ) . Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets . BMC Genomics vol. 8 ,
Gupta M, Raghavan M, Gale RE, Chelala C, Allen C, Molloy G, Chaplin T, Linch DC et al. ( 2007 ) . A genome-wide map of acquired uniparental disomy in acute myeloid leukemia . BLOOD . vol. 110 , 302A - 302A .
Mahon PC, Baril P, Bhakta V, Chelala C, Caulee K, Harada T, Lemoine NR ( 2007 ) . S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer . Cancer Res vol. 67 , ( 14 ) 6786 - 6795 .
Raghavan M, Smith LL, Chaplin T, Lillington D, Molloy G, Kakkas I, Chelala C, Cazier JB et al. ( 2007 ) . Frequent relapse of acute myeloid leukaemia by mitotic recombination . BRITISH JOURNAL OF HAEMATOLOGY . vol. 137 , 25 - 25 .
Chelala C, Duchatelet S, Joffret M-L, Bergholdt R, Dubois-Laforgue D, Ghandil P, Pociot F, Caillat-Zucman S et al. ( 2007 ) . PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits . Diabetes vol. 56 , ( 2 ) 522 - 526 .
Harada T, Baril P, Gangeswaran R, Kelly G, Chelala C, Bhakta V, Caulee K, Mahon PC et al. ( 2007 ) . Identification of genetic alterations in pancreatic cancer by the combined use of tissue microdissection and array-based comparative genomic hybridisation . Br J Cancer vol. 96 , ( 2 ) 373 - 382 .
Senée V, Chelala C, Duchatelet S, Feng D, Blanc H, Cossec J-C, Charon C, Nicolino M et al. ( 2006 ) . Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism . Nat Genet vol. 38 , ( 6 ) 682 - 687 .
Ghandil P, Chelala C, Dubois-Laforgue D, Senee V, Caillat-Zucman S, Kockum I, Luthman H, Nerup J et al. ( 2005 ) . Crohn's disease associated CARD15 (NOD2) variants are not involved in the susceptibility to type 1 diabetes . MOL GENET METAB vol. 86 , ( 3 ) 379 - 383 .
Chelala C, Auffray C ( 2005 ) . Sex-linked recombination variation and distribution of disease-related genes . Gene vol. 346 , 29 - 39 .
Imanishi T, Itoh T, Suzuki Y, O'Donovan C, Fukuchi S, Koyanagi KO, Barrero RA, Tamura T et al. ( 2004 ) . Integrative annotation of 21,037 human genes validated by full-length cDNA clones . PLoS Biol vol. 2 , ( 6 )
Chelala C, Debignes MD, Imbeaud S, Zoorob R, Auffray C, Curis E, Benazeth S, Cox D ( 2002 ) . Inconsistencies between maps of human chromosome 22 correlate with increased frequency of disease-related loci . J BIOL SYST vol. 10 , ( 4 ) 303 - 317 .
Eveno E, Mariage-Samson R, Bortoli S, Imbeaud S, Decraene C, Pietu G, CHELALA C, Devignes MD et al. ( 2002 ) . The Genexpress IMAGE Knowledge Base of the Human Genome and Transcriptomes . Analysing Gene Expression, A Handbook of Methods: Possibilities and Pitfalls , Editors: Lorkowski, S, Cullen, P , Wiley-VCH
Chelala C, Imbeaud S, Devignes MD, Zoorob R, Auffray C ( 2001 ) . Refined localization of twenty-one genes in subregion p13.1 of human chromosome 1 . CYTOGENET CELL GENET vol. 92 , ( 3-4 ) 209 - 212 .