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Research

Publications: Dr Xuenong Bo

Bo L, Bo X ( 2022 ) . Colony stimulating factor 1: friend or foe of neurons? . Neural Regeneration Research vol. 17 , ( 4 ) 773 - 774 .
Guijarro-Belmar A, Domanski D, Bo X, Shewan D, Huang W ( 2021 ) . The therapeutic potential of targeting exchange protein directly activated by cyclic adenosine 3′,5′-monophosphate (Epac) for central nervous system trauma . Neural Regeneration Research vol. 16 , ( 3 ) 460 - 469 .
Gushchina S, Yip PK, Parry GA, Sivakumar H, Li J, Liu M, Bo X ( 2021 ) . Alleviation of neuropathic pain by over-expressing a soluble colony-stimulating factor 1 receptor to suppress microgliosis and macrophage accumulation . GLIA
Guijarro-Belmar A, Viskontas M, Wei Y, Bo X, Shewan D, Huang W ( 2019 ) . Epac2 elevation reverses inhibition by chondroitin sulfate proteoglycans in vitro and transforms postlesion inhibitory environment to promote axonal outgrowth in an ex vivo model of spinal cord injury . Journal of Neuroscience vol. 39 , ( 42 ) 8330 - 8346 .
Bo X ( 2018 ) . Is ATP a key player in conditioning neurons to support axonal regeneration? . Neural Regen Res vol. 13 , ( 12 ) 2077 - 2079 .
BO XUENONG, GUSHCHINA S, PRYCE G, YIP P, WU D, PALLIER P, GIOVANNONI G, BAKER D ( 2018 ) . Increased expression of colony‐stimulating factor‐1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and neuronal loss . Glia vol. 66 , ( 10 ) 2108 - 2125 .
Wu D, Lee S, Luo J, Xia H, Gushchina S, Richardson PM, Yeh J, Krügel U et al. ( 2017 ) . Intraneural injection of ATP stimulates regeneration of primary sensory axons in the spinal cord . Journal of Neuroscience vol. 38 , ( 6 ) 1351 - 1365 .
BO X, Verhaagen J ( 2015 ) . Gene Delivery and Therapy for Neurological Disorders . Gene Delivery and Therapy for Neurological Disorders , Editors: BO, X , vol. 98 , Humana Press
Bo X, Zhang Y ( 2015 ) . Gene therapy approaches to promoting axonal regeneration after spinal cord injury . vol. 98 ,
Bo X, Verhaagen J ( 2015 ) . Preface .
Luo J, Lee S, Wu D, Yeh J, Ellamushi H, Wheeler AP, Warnes G, Zhang Y et al. ( 2013 ) . P2X7 purinoceptors contribute to the death of Schwann cells transplanted into the spinal cord . Cell Death Dis vol. 4 ,
Zhang Y, Gao F, Wu D, Moshayedi P, Zhang X, Ellamushi H, Yeh J, Priestley JV et al. ( 2013 ) . Lentiviral mediated expression of a NGF-soluble Nogo receptor 1 fusion protein promotes axonal regeneration . Neurobiol Dis vol. 58 , 270 - 280 .
Bo X, Wu D, Yeh J, Zhang Y ( 2011 ) . Gene therapy approaches for neuroprotection and axonal regeneration after spinal cord and spinal root injury . Curr Gene Ther vol. 11 , ( 2 ) 101 - 115 .
Miao T, Wu D, Wheeler A, Wang P, Zhang Y, Bo X, Yeh JS, Subang MC et al. ( 2011 ) . Two cytokine signaling molecules co-operate to promote axonal transport and growth . Exp Neurol vol. 228 , ( 2 ) 165 - 172 .
Luo JA, Bo XN, Wu DS, Yeh J, Richardson PM, Zhang Y ( 2011 ) . Promoting Survival, Migration, and Integration of Transplanted Schwann Cells by Over-Expressing Polysialic Acid . GLIA vol. 59 , ( 3 ) 424 - 434 .
Luo J, Bo X, Wu D, Yeh J, Richardson PM, Zhang Y ( 2011 ) . Promoting Survival, Migration, and Integration of Transplanted Schwann Cells by Over-expressing Polysialic Acid . Glia
Luo J, Bo X, Wu D, Yeh J, Richardson PM, Zhang Y ( 2010 ) . Promoting survival, migration, and integration of transplanted Schwann cells by over-expressing polysialic acid . Glia
Wu DS, Yang P, Zhang XY, Luo J, Haque ME, Yeh J, Richardson PM, Zhang Y et al. ( 2009 ) . Targeting a Dominant Negative Rho Kinase to Neurons Promotes Axonal Outgrowth and Partial Functional Recovery After Rat Rubrospinal Tract Lesion . MOL THER vol. 17 , ( 12 ) 2020 - 2030 .
Richardson PM, Miao T, Wu D, Zhang Y, Yeh J, Bo X ( 2009 ) . Responses of the nerve cell body to axotomy . Neurosurgery vol. 65 , ( SUPPL. 4 )
Richardson PM, Miao TZ, Wu DS, Zhang Y, Yeh J, Bo XN ( 2009 ) . RESPONSES OF THE NERVE CELL BODY TO AXOTOMY . NEUROSURGERY vol. 65 , ( 4 ) A74 - A79 .
Zhang Y, Yeh J, Richardson PM, Bo X ( 2008 ) . Cell adhesion molecules of the immunoglobulin superfamily in axonal regeneration and neural repair . Restorative Neurology and Neuroscience vol. 26 , ( 2-3 AXONAL REGENERATO ) 81 - 96 .
Miao TZ, Wu DS, Zhang Y, Bo XN, Xiao F, Zhang XY, Magoulas C, Subang MC et al. ( 2008 ) . SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun N-terminal kinase . MOL CELL NEUROSCI vol. 37 , ( 2 ) 367 - 375 .
Zhang Y, Yeh J, Richardson PM, Bo XN ( 2008 ) . Cell adhesion molecules of the immunoglobulin superfamily in axonal regeneration and neural repair . RESTOR NEUROL NEUROS vol. 26 , ( 2-3 ) 81 - 96 .
Zhang Y, Zhang XY, Wu DS, Verhaagen J, Richardson PM, Yeh J, Bo XN ( 2007 ) . Lentiviral-mediated expression of polysialic acid in spinal cord and conditioning lesion promote regeneration of sensory Axons into spinal cord . MOL THER vol. 15 , ( 10 ) 1796 - 1804 .
Zhang Y, Ghadiri-Sani M, Zhang XY, Richardson PM, Yeh J, Bo XN ( 2007 ) . Induced expression of polysialic acid in the spinal cord promotes regeneration of sensory axons . MOL CELL NEUROSCI vol. 35 , ( 1 ) 109 - 119 .
Wu DS, Zhang Y, Bo XN, Huang WL, Xiao F, Zhang XY, Miao TZ, Magoulas C et al. ( 2007 ) . Actions of neuropoietic cytokines and cyclic AMP in regenerative conditioning of rat primary sensory neurons . EXP NEUROL vol. 204 , ( 1 ) 66 - 76 .
Zhang Y, Zhang X, Yeh J, Richardson P, Bo X ( 2007 ) . Engineered expression of polysialic acid enhances Purkinje cell axonal regeneration in L1/GAP-43 double transgenic mice . Eur J Neurosci vol. 25 , ( 2 ) 351 - 361 .
Miao T, Wu DS, Zhang Y, Bo XN, Subang MC, Wang P, Richardson PM ( 2006 ) . Suppressor of cytokine signaling-3 suppresses the ability of activated signal transducer and activator of transcription-3 to stimulate neurite growth in rat primary sensory neurons . J NEUROSCI vol. 26 , ( 37 ) 9512 - 9519 .
Zhang XY, Bo XN, Anderson PN, Lieberman AR, Zhang Y ( 2006 ) . Distribution and expression of tissue inhibitors of metalloproteinase in dorsal root entry zone and dorsal column after dorsal root injury . J NEUROSCI RES vol. 84 , ( 2 ) 278 - 290 .
Zhang Y, Bo XN, Schoepfer R, Holtmaat AJDG, Verhaagen J, Emson PC, Lieberman AR, Anderson PN ( 2005 ) . Growth-associated protein GAP-43 and L1 act synergistically to promote regenerative growth of Purkinje cell axons in vivo . P NATL ACAD SCI USA vol. 102 , ( 41 ) 14883 - 14888 .
Zhang Y, Bo X, Schoepfer R, Holtmaat AJDG, Verhaagen J, Emson PC, Lieberman AR, Anderson PN ( 2005 ) . Growth-associated protein GAP-43 and L1 act synergistically to promote regenerative growth of Purkinje cell axons in vivo . Proc Natl Acad Sci U S A vol. 102 , ( 41 ) 14883 - 14888 .
Jiang LH, Kim M, Spelta V, Bo XN, Surprenant A, North RA ( 2003 ) . Subunit arrangement in P2X receptors . J NEUROSCI vol. 23 , ( 26 ) 8903 - 8910 .
Bo XN, Jiang LH, Wilson HL, Kim M, Burnstock G, Surprenant A, North RA ( 2003 ) . Pharmacological and biophysical properties of the human P2X(5) receptor . MOL PHARMACOL vol. 63 , ( 6 ) 1407 - 1416 .
Bo XN, Kim M, Nori SL, Schoepfer R, Burnstock G, North RA ( 2003 ) . Tissue distribution of P2X(4) receptors studied with an ectodomain antibody . CELL TISSUE RES vol. 313 , ( 2 ) 159 - 165 .
BO X, Liu M, Burnstock G, Schoepfer R ( 2001 ) . Characterization and expression of ATP P2X(4) receptor from embryonic chick skeletal muscle . Drug Develop Res. vol. 53 , 22 - 28 .
Bo X, Burnstock G ( 2001 ) . Localization of ATP P2X Receptors . Ion Channel Localization Methods and Protocols , Editors: Lopatin, A, Nichols, C , The Humana Press Inc ( Totowa ),
Bo XN, Schoepfer R, Burnstock G ( 2000 ) . Molecular cloning and characterization of a novel ATP P2X receptor subtype from embryonic chick skeletal muscle . J BIOL CHEM vol. 275 , ( 19 ) 14401 - 14407 .
Bo X, Alavi A, Xiang Z, Oglesby I, Ford A, Burnstock G ( 1999 ) . Localization of ATP-gated P2X2 and P2X3 receptor immunoreactive nerves in rat taste buds . NeuroReport vol. 10 , ( 5 ) 1107 - 1111 .
Xiang Z, Bo X, Burnstock G ( 1999 ) . P2X receptor immunoreactivity in the rat cochlea, vestibular ganglion and cochlear nucleus . vol. 128 , ( 1-2 ) 190 - 196 .
Nori S, Fumagalli L, Bo X, Bogdanov Y, Burnstock G ( 1998 ) . Coexpression of mRNAs for P2X1, P2X2 and P2X4 receptors in rat vascular smooth muscle: an in situ hybridization and RT-PCR study . J Vasc Res vol. 35 , ( 3 ) 179 - 185 .
Xiang Z, Bo X, Burnstock G ( 1998 ) . Localization of ATP-gated P2X receptor immunoreactivity in rat sensory and sympathetic ganglia . Neuroscience Letters vol. 256 , ( 2 ) 105 - 108 .
Xiang Z, Bo X, Oglesby I, Ford A, Burnstock G ( 1998 ) . Localization of ATP-gated P2X2 receptor immunoreactivity in the rat hypothalamus . Brain Research vol. 813 , ( 2 ) 390 - 397 .
Bo X, Karoon P, Nori SL, Bardini M, Burnstock G ( 1998 ) . P2X purinoceptors in postmortem human cerebral arteries . Journal of Cardiovascular Pharmacology vol. 31 , ( 5 ) 794 - 799 .
Bo X, Sexton A, Xiang Z, Nori SL, Burnstock G ( 1998 ) . Pharmacological and histochemical evidence for P2X receptors in human umbilical vessels . European Journal of Pharmacology vol. 353 , ( 1 ) 59 - 65 .
Zhong Y, Dunn PM, Xiang Z, Bo X, Burnstock G ( 1998 ) . Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons . British Journal of Pharmacology vol. 125 , ( 4 ) 771 - 781 .
Vallejo AI, Bo XN, Burnstock G ( 1996 ) . P2Y purinoceptors in gastric gland plasma membranes . EUR J PHARMACOL vol. 312 , ( 2 ) 209 - 214 .
Lambrecht G, Ardanuy U, Bäumert HG, Bo X, Hoyle CHV, Nickel P, Pfaff O, Ralevic V et al. ( 1996 ) . Design and pharmacological characterization of selective P2-purinoceptor antagonists . Perspectives in Receptor Research , Editors: Giardinà, D, Piergentili, A, Pigini, M , Elsevier ( Amsterdam ),
Zhao M, Bo X, Burnstock G ( 1996 ) . Distribution of [3H] alpha, beta-methylene ATP binding sites in pulmonary blood vessels of different species . Pulm Pharmacol vol. 9 , ( 3 ) 167 - 174 .
Neely CF, Matot I, Batra VK, Bo XN, Burnstock G ( 1996 ) . P-2X purinoceptors in the feline pulmonary vascular bed: Distribution and selective in vivo pharmacological probes . AM J PHYSIOL-LUNG C vol. 14 , ( 6 ) L889 - L897 .
Zhao M, Bo XN, Neely CF, Burnstock G ( 1996 ) . Characterization and autoradiographic localization of [H-3]alpha,beta-methylene ATP binding sites in cat urinary bladder . GEN PHARMACOL vol. 27 , ( 3 ) 509 - 512 .
BO XN, ZHANG Y, NASSAR M, BURNSTOCK G, SCHOEPFER R ( 1995 ) . A P2X PURINOCEPTOR CDNA CONFERRING A NOVEL PHARMACOLOGICAL PROFILE . FEBS LETT vol. 375 , ( 1-2 ) 129 - 133 .
Bo X, Burnstock G ( 1995 ) . Characterization and autoradiographic localization of [3H] alpha, beta-methylene adenosine 5'-triphosphate binding sites in human urinary bladder . Br J Urol vol. 76 , ( 3 ) 297 - 302 .
MOCKETT BG, BO XN, HOUSLEY GD, THORNE PR, BURNSTOCK G ( 1995 ) . AUTORADIOGRAPHIC LABELING OF P-2 PURINOCEPTORS IN THE GUINEA-PIG COCHLEA . HEARING RES vol. 84 , ( 1-2 ) 177 - 193 .
BO XN, BURNSTOCK G ( 1994 ) . DISTRIBUTION OF [H-3] ALPHA,BETA-METHYLENE ATP BINDING-SITES IN RAT-BRAIN AND SPINAL-CORD . NEUROREPORT vol. 5 , ( 13 ) 1601 - 1604 .
BO XN, FISCHER B, MAILLARD M, JACOBSON KA, BURNSTOCK G ( 1994 ) . COMPARATIVE-STUDIES ON THE AFFINITIES OF ATP DERIVATIVES FOR P-2X-PURINOCEPTORS IN RAT URINARY-BLADDER . BRIT J PHARMACOL vol. 112 , ( 4 ) 1151 - 1159 .
ZIGANSHIN AU, HOYLE CHV, BO XN, LAMBRECHT G, MUTSCHLER E, BAUMERT HG, BURNSTOCK G ( 1993 ) . PPADS SELECTIVELY ANTAGONIZES P(2X)-PURINOCEPTOR-MEDIATED RESPONSES IN THE RABBIT URINARY-BLADDER . BRIT J PHARMACOL vol. 110 , ( 4 ) 1491 - 1495 .
BO XN, BURNSTOCK G ( 1993 ) . TRIPHOSPHATE, THE KEY STRUCTURE OF THE ATP MOLECULE RESPONSIBLE FOR INTERACTION WITH P(2X)-PURINOCEPTORS . GEN PHARMACOL vol. 24 , ( 3 ) 637 - 640 .
BO XN, BURNSTOCK G ( 1993 ) . HETEROGENEOUS DISTRIBUTION OF [H-3] ALPHA,BETA-METHYLENE ATP BINDING-SITES IN BLOOD-VESSELS . J VASC RES vol. 30 , ( 2 ) 87 - 101 .
Simon J, Bo X, Burnstock G, Barnard EA ( 1993 ) . Solubilisation and molecular characterisation of the P(2X) purinoceptor . Biochemical Society Transactions . vol. 21 ,
BO XN, SIMON J, BURNSTOCK G, BARNARD EA ( 1992 ) . SOLUBILIZATION AND MOLECULAR-SIZE DETERMINATION OF THE P(2X) PURINOCEPTOR FROM RAT VAS-DEFERENS . J BIOL CHEM vol. 267 , ( 25 ) 17581 - 17587 .
BO XN, BURNSTOCK G ( 1992 ) . SPECIES-DIFFERENCES IN CHARACTERISTICS AND DISTRIBUTION OF [H-3] ALPHA,BETA-METHYLENE ATP BINDING-SITES IN URINARY-BLADDER AND URETHRA OF RAT, GUINEA-PIG AND RABBIT . EUR J PHARMACOL vol. 216 , ( 1 ) 59 - 66 .
BO XN, NEELY CF, BURNSTOCK G ( 1992 ) . AUTORADIOGRAPHIC LOCALIZATION OF P2-PURINOCEPTORS IN CAT AND HUMAN PULMONARY VESSELS WITH [H-3] ALPHA,BETA-MEATP . FASEB J vol. 6 , ( 4 ) A1555 - A1555 .
Bo XN, Burnstock G ( 1990 ) . High- and low-affinity binding sites for [3H]-alpha, beta-methylene ATP in rat urinary bladder membranes . Br J Pharmacol vol. 101 , ( 2 ) 291 - 296 .
Bo XN, Burnstock G ( 1990 ) . The effects of Bay K 8644 and nifedipine on the responses of rat urinary bladder to electrical field stimulation, beta,gamma-methylene ATP and acetylcholine . Br J Pharmacol vol. 101 , ( 2 ) 494 - 498 .
Bo X, Burnstock G ( 1989 ) . [3H]-alpha, beta-methylene ATP, a radioligand labelling P2-purinoceptors . Journal of Autonomic Nervous System vol. 28 , ( 1 ) 85 - 88 .
Bo X, Burnstock G ( 1989 ) . [<sup>3</sup>H]-α,β-Methylene ATP, a radioligand labelling P<inf>2</inf>-purinoceptors . Journal of the Autonomic Nervous System vol. 28 , ( 1 ) 85 - 88 .