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Research

Publications: Prof Michele Bombardieri

Pezoulas VC, Goules A, Kalatzis F, Chatzis L, Kourou KD, Venetsanopoulou A, Exarchos TP, Gandolfo S et al. ( 2022 ) . Addressing the clinical unmet needs in primary Sjögren's Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts . Computational and Structural Biotechnology Journal vol. 20 , 471 - 484 .
Iqbal AJ, Krautter F, Blacksell IA, Wright RD, Austin-Williams SN, Voisin MB, Hussain MT, Law HL et al. ( 2022 ) . Galectin-9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin-dependent manner . FASEB Journal vol. 36 , ( 1 )
Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Goldmann K, Fossati-Jimack L et al. ( 2021 ) . OP0136 RITUXIMAB PREVENTS THE PROGRESSION OF B-CELL DRIVEN INFLAMMATORY INFILTRATE IN THE MINOR SALIVARY GLANDS OF PRIMARY SJOGREN’S SYNDROME BY DOWNREGULATING IMMUNOLOGICAL PATHWAYS KEY IN ECTOPIC GERMINAL CENTRE ORGANIZATION: RESULTS FROM THE TRACTISS TRIAL . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 79 - 80 .
Pontarini E, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Fossati-Jimack L, Coleby R, Chowdhury F et al. ( 2021 ) . NKp30 Receptor Upregulation in Salivary Glands of Sjögren’s Syndrome Characterizes Ectopic Lymphoid Structures and Is Restricted by Rituximab Treatment . Frontiers in Immunology vol. 12 ,
Arends S, de Wolff L, van Nimwegen JF, Verstappen GMPJ, Vehof J, Bombardieri M, Bowman SJ, Pontarini E et al. ( 2021 ) . Composite of Relevant Endpoints for Sjögren's Syndrome (CRESS): development and validation of a novel outcome measure . The Lancet Rheumatology vol. 3 , ( 8 ) e553 - e562 .
Chowdhury F, Tappuni A, Bombardieri M ( 2021 ) . Biological Therapy in Primary Sjögren's Syndrome: Effect on Salivary Gland Function and Inflammation . Frontiers in Medicine vol. 8 ,
Rivellese F, Pontarini E, Fossati-Jimack L, Moura RA, Romão VC, Fonseca JE, Nerviani A, Cubuk C et al. ( 2021 ) . OP0011 INTEGRATION OF FLOW AND DIGITAL CYTOMETRY IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS IDENTIFIES DISTINCT IMMUNOPHENOTYPES IN PERIPHERAL BLOOD AND DISEASE TISSUE . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 7.2 - 7.7 .
Arends S, de Wolff L, Van Nimwegen JF, Verstappen GM, Vehof J, Bombardieri M, Bowman SJ, Pontarini E et al. ( 2021 ) . OP0130 COMPOSITE OF RELEVANT ENDPOINTS IN SJÖGREN’S SYNDROME (CRESS): A COMPREHENSIVE TOOL FOR CLINICAL TRIALS . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 74.1 - 7475 .
Jimenez-Royo P, Bombardieri M, Ciurtin C, Kostapanos M, Tappuni AR, Jordan N, Saleem A, Fuller T et al. ( 2021 ) . Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren's syndrome . Rheumatology (United Kingdom) vol. 60 , ( 5 ) 2396 - 2408 .
Fanelli G, Romano M, Nova-Lamperti E, Sunderland MW, Nerviani A, Scottà C, Bombardieri M, Quezada SA et al. ( 2021 ) . PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype . PLoS Biology vol. 19 , ( 4 )
Rivellese F, Manou-Stathopoulou S, Mauro D, Goldmann K, Pyne D, Rajakariar R, Gordon P, Schafer P et al. ( 2021 ) . Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus . Lupus Science and Medicine vol. 8 , ( 1 )
Giacomelli R, Afeltra A, Bartoloni E, Berardicurti O, Bombardieri M, Bortoluzzi A, Carubbi F, Caso F et al. ( 2021 ) . The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus . Autoimmunity Reviews vol. 20 , ( 2 )
Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G et al. ( 2021 ) . Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial . The Lancet vol. 397 , ( 10271 ) 305 - 317 .
Pontarini E, Verstappen GM, Grigoriadou S, Kroese FGM, Bootsma H, Bombardieri M ( 2021 ) . Blocking T cell co-stimulation in primary Sjögren's syndrome: Rationale, clinical efficacy and modulation of peripheral and salivary gland biomarkers . Clinical and Experimental Rheumatology vol. 38 , ( 4 ) S222 - S227 .
Pontarini E, Coleby R, Bombardieri M ( 2021 ) . Cellular and molecular diversity in Sjogren's syndrome salivary glands: Towards a better definition of disease subsets . Seminars in Immunology
De Wolff L, Arends S, Pontarini E, Bombardieri M, Bowman SJ, Bootsma H ( 2021 ) . Development and performance of the Clinical Trials ESSDAI (ClinTrialsESSDAI), consisting of frequently active clinical domains, in two randomised controlled trials in primary Sjögren's syndrome . Clinical and Experimental Rheumatology vol. 39 , ( 6 ) S100 - S106 .
Retamozo S, Acar-Denizli N, Horváth IF, Ng WF, Rasmussen A, Dong X, Li X, Baldini C et al. ( 2021 ) . Influence of the age at diagnosis in the disease expression of primary Sjögren's syndrome. Analysis of 12,753 patients from the Sjögren Big Data Consortium . Clinical and Experimental Rheumatology vol. 39 , ( 6 ) S166 - S174 .
Bombardieri M, Argyropoulou OD, Ferro F, Coleby R, Pontarini E, Governato G, Lucchesi D, Fulvio G et al. ( 2021 ) . One year in review 2020: Pathogenesis of primary Sjögren's syndrome . Clinical and Experimental Rheumatology vol. 38 , ( 4 ) S3 - S9 .
Delvecchio FR, Fincham REA, Spear S, Clear A, Roy-Luzarraga M, Balkwill FR, Gribben JG, Bombardieri M et al. ( 2021 ) . Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice . Cellular and Molecular Gastroenterology and Hepatology vol. 12 , ( 5 ) 1543 - 1565 .
Chowdhury F, Grigoriadou S, Bombardieri M ( 2021 ) . Severity of COVID-19 infection in primary Sjögren's syndrome and the emerging evidence of COVID-19-induced xerostomia . Clinical and Experimental Rheumatology vol. 39 , ( 6 ) S215 - S222 .
Coleby R, Lucchesi D, Pontarini E, Pitzalis C, Bombardieri M ( 2021 ) . Stepwise changes in the murine salivary gland immune response during virally-induced ectopic lymphoid structure formation . Clinical and Experimental Rheumatology vol. 39 , ( 6 ) S39 - S48 .
Lucchesi D, Pontarini E, Donati V, Mandarano M, Sidoni A, Bartoloni E, Baldini C, Tappuni AR et al. ( 2021 ) . The use of digital image analysis in the histological assessment of Sjögren's syndrome salivary glands improves inter-rater agreement and facilitates multicentre data harmonisation . Clinical and Experimental Rheumatology vol. 38 , ( 4 ) S180 - S188 .
Price E, Allen A, Rauz S, Tappuni A, Sutcliffe N, Bombardieri M, Carty S, Ciurtin C et al. ( 2020 ) . The management of Sjögren's syndrome: British Society for Rheumatology guideline scope . Rheumatology
Pontarini E, Murray-Brown WJ, Croia C, Lucchesi D, Conway J, Rivellese F, Fossati-Jimack L, Astorri E et al. ( 2020 ) . Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren's syndrome with ectopic germinal centres and MALT lymphoma . Annals of the Rheumatic Diseases vol. 79 , ( 12 ) 1588 - 1599 .
Nerviani A, Boutet M-A, Ghirardi GM, Lliso-Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2020 ) . MerTK Synovial Expression Correlates with Disease Activity and Treatment Response in Rheumatoid Arthritis Patients . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,
Meednu N, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, Bombardieri M, DiCarlo E, Orange D et al. ( 2020 ) . Role of NR4A Nuclear Receptor Family in RA Synovial Ectopic Lymphoid Neogenesis Revealed by Single Cell Profiling . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,
Brito-Zerón P, Acar-Denizli N, Ng WF, Horváth IF, Rasmussen A, Seror R, Li X, Baldini C et al. ( 2020 ) . Epidemiological profile and north-south gradient driving baseline systemic involvement of primary Sjögren's syndrome . Rheumatology (United Kingdom) vol. 59 , ( 9 ) 2350 - 2359 .
Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill DG, Derrac Soria A, Jones SA et al. ( 2020 ) . Impaired Interleukin-27–Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjögren's Syndrome . Arthritis and Rheumatology vol. 72 , ( 9 ) 1559 - 1570 .
Nerviani A, Boutet MA, Ghirardi GM, Lliso Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2020 ) . THU0082 MERTK SYNOVIAL EXPRESSION CORRELATES WITH TREATMENT RESPONSE IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 79 , 253.1 - 25253 .
Nerviani A, Di Cicco M, Mahto A, Lliso-Ribera G, Rivellese F, Thorborn G, Hands R, Bellan M et al. ( 2020 ) . A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients . Frontiers in Immunology vol. 11 ,
Corsiero E, Carlotti E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M ( 2020 ) . H and L chain affinity maturation and/or Fab N-glycosylation influence immunoreactivity toward neutrophil extracellular trap antigens in rheumatoid arthritis synovial b cell clones . Journal of Immunology vol. 204 , ( 9 ) 2374 - 2379 .
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . B CELL-RICH SYNOVITIS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 59 ,
Nerviani A, Lliso-Ribera G, Boutet M-A, Goldmann K, Rivellese F, Kelly S, Bombardieri M, Lewis M et al. ( 2020 ) . HISTOLOGICAL AND MOLECULAR FEATURES OF THE DISEASED SYNOVIUM IN EARLY UNTREATED PSA IN COMPARISON WITH RA . RHEUMATOLOGY . vol. 59 ,
Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill D, Soria AD, Jones S et al. ( 2020 ) . IL-27 REGULATES THE MAGNITUDE OF ECTOPIC GERMINAL CENTRES IN EXPERIMENTAL SIALADENITIS BUT FAILS TO MODULATE IL-17 AND IFNG PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJOGREN'S SYNDROME . RHEUMATOLOGY . vol. 59 ,
Humby FC, Lewis M, Durez P, Buch MH, Bombardieri M, Rizvi H, Rivellese F, Fossati L et al. ( 2020 ) . O07 Randomised, open labelled clinical trial to investigate synovial mechanisms determining response: resistance to rituximab versus tocilizumab in RA patients failing TNF inhibitor therapy . Rheumatology . vol. 59 ,
Nerviani A, Lliso-Ribera G, Boutet M-A, Goldmann K, Rivellese F, Kelly S, Bombardieri M, Lewis M et al. ( 2020 ) . O20 Histological and molecular features of the diseased synovium in early untreated PsA in comparison with RA . Rheumatology . vol. 59 ,
Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill D, Soria AD, Jones S et al. ( 2020 ) . O31 IL-27 regulates the magnitude of ectopic germinal centres in experimental sialadenitis but fails to modulate IL-17 and IFNg production in CD4 T cells from patients with Sjögren's syndrome . Rheumatology . vol. 59 ,
Humby FC, Lewis M, Durez P, Buch MH, Bombardieri M, Rizvi H, Rivellese F, Fossati L et al. ( 2020 ) . RANDOMISED, OPEN LABELLED CLINICAL TRIAL TO INVESTIGATE SYNOVIAL MECHANISMS DETERMINING RESPONSE: RESISTANCE TO RITUXIMAB VERSUS TOCILIZUMAB IN RA PATIENTS FAILING TNF INHIBITOR THERAPY . RHEUMATOLOGY . vol. 59 , 3 - + .
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure . Arthritis and Rheumatology
Fisher BA, Szanto A, Ng WF, Bombardieri M, Posch MG, Papas AS, Farag AM, Daikeler T et al. ( 2020 ) . Assessment of the anti-CD40 antibody iscalimab in patients with primary Sjögren's syndrome: a multicentre, randomised, double-blind, placebo-controlled, proof-of-concept study . The Lancet Rheumatology vol. 2 , ( 3 ) e142 - e152 .
Pontarini E, Verstappen GM, Grigoriadou S, Kroese FGM, Bootsma H, Bombardieri M ( 2020 ) . Blocking T cell co-stimulation in primary Sjogren's syndrome: rationale, clinical efficacy and modulation of peripheral and salivary gland biomarkers . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 38 , ( 4 ) S222 - S227 .
Colafrancesco S, Priori R, Smith CG, Minniti A, Iannizzotto V, Pipi E, Lucchesi D, Pontarini E et al. ( 2020 ) . CXCL13 as biomarker for histological involvement in Sjögren's syndrome . Rheumatology (United Kingdom) vol. 59 , ( 1 ) 165 - 170 .
Bombardieri M, Argyropoulou OD, Ferro F, Coleby R, Pontarini E, Governato G, Lucchesi D, Fulvio G et al. ( 2020 ) . One year in review 2020: pathogenesis of primary Sjogren's syndrome . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 38 , ( 4 ) S3 - S9 .
Lucchesi D, Pontarini E, Donati V, Mandarano M, Sidoni A, Bartoloni E, Baldini C, Tappuni AR et al. ( 2020 ) . The use of digital image analysis in the histological assessment of Sjogren's syndrome salivary glands improves inter-rater agreement and facilitates multicentre data harmonisation . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 38 , ( 4 ) S180 - S188 .
Pucino V, Certo M, Bulusu V, Cucchi D, Goldmann K, Pontarini E, Haas R, Smith J et al. ( 2019 ) . Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring . Cell Metabolism
Davies K, Mirza K, Tarn J, Howard-Tripp N, Bowman SJ, Lendrem D, Ng WF, Hall F et al. ( 2019 ) . Fatigue in primary Sjögren’s syndrome (pSS) is associated with lower levels of proinflammatory cytokines: a validation study . Rheumatology International vol. 39 , ( 11 ) 1867 - 1873 .
Mariette X, Bombardieri M, Alevizos I, Moate R, Sullivan B, Noaiseh G, Kvarnstrom M, Rees W et al. ( 2019 ) . A Phase 2a Study of MEDI5872 (AMG557), a Fully Human Anti-ICOS Ligand Monoclonal Antibody in Patients with Primary Sjogren's Syndrome . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,
Humby F, Buch MH, Durez P, Lewis M, Bombardieri M, Rizvi H, Kelly S, Fosatti L et al. ( 2019 ) . A Randomised, Open Labelled Clinical Trial to Investigate Synovial Mechanisms Determining Response - Resistance to Rituximab versus Tocilizumab in Rheumatoid Arthritis Patients Failing TNF Inhibitor Therapy . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,
Corsiero E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M ( 2019 ) . Characterization of calreticulin, a stromal-derived autoantigens, recognized by RA synovial recombinant monoclonal antibodies . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 773 - 774 .
Pucino V, Certo M, Bulusu V, Goldmann K, Cucchi D, Haas R, Smith J, Blighe K et al. ( 2019 ) . Lactate influx into human CD4+T-cells, via SLC5A12, causes STAT3-and fatty acid synthesis-mediated IL17 expression and tissue retention . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 1276 - 1277 .
Tarn JR, Howard-Tripp N, Lendrem DW, Mariette X, Saraux A, Devauchelle-Pensec V, Seror R, Skelton AJ et al. ( 2019 ) . Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials . The Lancet Rheumatology vol. 1 , ( 2 ) e85 - e94 .
Prediletto E, Pontarini E, Lucchesi D, Corsiero E, Pratesi F, Migliorini P, Pitzalis C, Bombardieri M ( 2019 ) . Synovial fluid fibroblast-like synoviocytes enhance long-term survival of EBV infected memory B cells in rheumatoid arthritis . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 791 - 791 .
Grigoriadou S, Chowdhury F, Pontarini E, Tappuni A, Bowman SJ, Bombardieri M ( 2019 ) . B-cell depletion with rituximab in the treatment of primary Sjögren's syndrome: What have we learnt? . Clinical and Experimental Rheumatology vol. 37 , S217 - S224 .
Lewis MJ, Barnes MR, Blighe K, Goldmann K, Rana S, Hackney JA, Ramamoorthi N, John CR et al. ( 2019 ) . Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes . Cell Reports vol. 28 , 2455 - 2470 .
Retamozo S, Acar-Denizli N, Rasmussen A, Horváth IF, Baldini C, Priori R, Sandhya P, Hernandez-Molina G et al. ( 2019 ) . Systemic manifestations of primary Sjögren's syndrome out of the ESSDAI classification: Prevalence and clinical relevance in a large international, multi-ethnic cohort of patients . Clinical and Experimental Rheumatology vol. 37 , S97 - S106 .
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Ribera GL, Nerviani A et al. ( 2019 ) . THU0058 B CELL SYNOVITIS AND CLINICAL PHENOTYPES IN RHEUMATOID ARTHRITIS AT DIFFERENT DISEASE STAGES . https://ard.bmj.com/content/78/Suppl_2 . Conference: Annual European Congress of Rheumatology, EULAR 2019 ( Madrid ) from: 12/06/2019 to: 15/06/2019 , 296.2 - 29297 .
Vomero M, Caliste M, Barbati C, Colasanti T, Spinelli F, Ceccarelli F, Perricone C, Finucci A et al. ( 2019 ) . AB0145 THE INHIBITION OF JAK PATHWAY WAS ASSOCIATED WITH REDUCTION OF AUTOPHAGY IN SYNOVIOCYTES FROM RHEUMATOID ARTHRITIS PATIENTS . 1530.3 - 151531 .
Manou-Stathopoulou S, Rivellese F, Mauro D, Goldmann K, Pyne D, Schafer P, Bombardieri M, Pitzalis C et al. ( 2019 ) . AB0179 THE TRANSCRIPTION FACTORS IKZF1 AND IKZF3 CONTROL B CELL ACTIVATION AND DIFFERENTIATION IN SYSTEMIC LUPUS ERYTHEMATOSUS . 1548.1 - 151548 .
Bombardieri M, Ciurtin C, Kostapanos M, Astorri E, Tappuni A, Jordan N, Azeem S, Fuller T et al. ( 2019 ) . AB0496  18 F-FDG-PET/CT, 11 C-METHIONINE-PET/CT AND MULTI-PARAMETRIC MRI IN THE EVALUATION OF DISEASE ACTIVITY AND GLAND FUNCTION IN PRIMARY SJÖGREN’S SYNDROME . Conference: Abstracts Accepted for Publication1711.2 - 171711 .
Retamozo S, Acar-Denizli N, Ng WF, Horváth IF, Rasmussen A, Seror R, Xiaomei L, Baldini C et al. ( 2019 ) . AB0550 PHENOTYPE OF BIOPSY-PROVEN PATIENTS WITH PRIMARY SJÖGREN SYNDROME LACKING RO AUTOANTIBODIES: HIGH FREQUENCY OF DRYNESS SYMPTOMS WITH LOW SYSTEMIC ACTIVITY (BIG DATA SJÖGREN PROJECT) . Conference: Abstracts Accepted for Publication1736.2 - 171737 .
Fisher B, Szántó A, Ng WF, Bombardieri M, Posch M, Papas A, Farag A, Daikeler T et al. ( 2019 ) . FRI0174 SUBCUTANEOUS DOSING OF THE NOVEL ANTI-CD40 ANTIBODY ISCALIMAB ACHIEVES TARGET DRUG EXPOSURE AND CLINICAL EFFICACY IN PRIMARY SJÖGREN’S SYNDROME; RESULTS OF A PHASE IIA RANDOMISED OPEN LABEL TWO ARM PARALLEL GROUP TRIAL . Conference: Poster Presentations760.2 - 76761 .
Retamozo S, Acar-Denizli N, Ng WF, Szanto A, Rasmussen A, Seror R, Xiaomei L, Baldini C et al. ( 2019 ) . LYMPHOMA ARISING AT THE TIME OF DIAGNOSIS OF PRIMARY SJOGREN SYNDROME: A HIGHLY-ACTIVE SYSTEMIC SUBSET OF THE DISEASE . ANNALS OF THE RHEUMATIC DISEASES . vol. 78 , 138 - 138 .
Nerviani A, Ribera GL, Boutet MA, Goldmann K, Kelly S, Bombardieri M, Lewis M, Humby F et al. ( 2019 ) . OP0113 HISTOLOGICAL AND MOLECULAR PORTRAIT OF THE SYNOVIAL TISSUE IN EARLY TREATMENT-NAÏVE PSORIATIC ARTHRITIS IN COMPARISON WITH RHEUMATOID ARTHRITIS . 130 - 131 .
Ribera GL, Humby F, Nerviani A, Lewis M, Kelly S, Bombardieri M, Goldmann K, Hands R et al. ( 2019 ) . OP0120 BASELINE CELLULAR AND MOLECULAR CHARACTERISTICS OF SYNOVIAL TISSUE AND RELATION WITH TNFI RESPONSE. RESULTS FROM THE PATHOBIOLOGY OF THE EARLY ARTHRITIS COHORT (PEAC) . 134 - 134 .
Lucchesi D, Coleby R, Pontarini E, Prediletto E, Hill D, Soria AD, Rivellese F, Pitzalis C et al. ( 2019 ) . OP0276 DENDRITIC CELL-DERIVED IL-27 REGULATES THE MAGNITUDE OF INDUCIBLE ECTOPIC GERMINAL CENTRES BUT FAILS TO DOWNMODULATE IL-17 PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJÖGREN’S SYNDROME . Conference: Oral Presentations220.1 - 22220 .
Pontarini E, Brown WM, Croia C, Lucchesi D, Rivellese F, Fossati-Jimack L, Ruscitti P, Prediletto E et al. ( 2019 ) . OP0279 A UNIQUE IL-21 SIGNATURE CHARACTERIZES LESIONAL AND CIRCULATING T-FOLLICULAR HELPER CELLS IN SJÖGREN’S SYNDROME PATIENTS WITH ECTOPIC GERMINAL CENTRES AND MALT LYMPHOMA . Conference: Oral Presentations221.1 - 22221 .
Rivellese F, Manou-Stathopoulou S, Mauro D, Pontarini E, Lucchesi D, Congia M, Schafer P, Sutcliffe N et al. ( 2019 ) . THU0234 THE TRANSCRIPTION FACTORS IKAROS (IKZF1) AND AIOLOS (IKZF3) ARE EXPRESSED IN THE SALIVARY GLANDS OF SJÖGREN’S SYNDROME PATIENTS WITH LYMPHOID AGGREGATES AND MODULATE B CELL ACTIVATION IN VITRO . 394.2 - 39395 .
Retamozo S, Acar-Denizli N, Ng WF, Horváth IF, Rasmussen A, Seror R, Xiaomei L, Baldini C et al. ( 2019 ) . THU0277 HOW THE AGE AT DIAGNOSIS MODIFIES THE PHENOTYPE OF PRIMARY SJÖGREN SYNDROME: ANALYSIS IN 11,420 PATIENTS (BIG DATA SJÖGREN PROJECT) . Conference: Poster Presentations416.2 - 41417 .
Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V et al. ( 2019 ) . PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes . Annals of the Rheumatic Diseases vol. 78 , ( 5 ) 600 - 609 .
Manou-Stathopoulou S, Rivellese F, Mauro D, Goldmann K, Pyne D, Schafer P, Bombardieri M, Pitzalis C et al. ( 2019 ) . 235 IKZF1 and IKZF3 inhibition impairs B cell differentiation and modulates gene expression in systemic lupus erythematosus . a174.2 - a1a175 .
Hackett KL, Davies K, Tarn J, Bragg R, Hargreaves B, Miyamoto S, McMeekin P, Mitchell S et al. ( 2019 ) . Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren's syndrome . RMD Open vol. 5 , ( 1 )
HUMBY F ( 2019 ) . Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients . Annals of the Rheumatic Diseases
Nocturne G, Pontarini E, Bombardieri M, Mariette X ( 2019 ) . Lymphomas complicating primary Sjögren's syndrome: from autoimmunity to lymphoma . Rheumatology (Oxford)
Pontarini E, Lucchesi D, Fossati-Jimack L, Coleby R, Tentorio P, Croia C, Bombardieri M, Mavilio D ( 2019 ) . NK cell recruitment in salivary glands provides early viral control but is dispensable for tertiary lymphoid structure formation . Journal of Leukocyte Biology vol. 105 , ( 3 ) 589 - 602 .
Colafrancesco S, Priori R, Smith C, Minniti A, Iannizzotto V, Pipi E, Nayar S, Campos J et al. ( 2019 ) . P055 CXCL13 as biomarker for histological involvement in sjogren’s syndrome . Annals of the Rheumatic Diseases . vol. 78 ,
PITZALIS C, CORSIERO E, DELVECCHIO F, BOMBARDIERI M ( 2019 ) . B cells in the formation of Tertiary Lymphoid Organs in autoimmunity, transplantation and tumorigenesis . Current Opinion in Immunology vol. 57 , 46 - 52 .
Vomero M, Manganelli V, Barbati C, Colasanti T, Capozzi A, Finucci A, Spinelli FR, Ceccarelli F et al. ( 2019 ) . Reduction of autophagy and increase in apoptosis correlates with a favorable clinical outcome in patients with rheumatoid arthritis treated with anti-TNF drugs . Arthritis Research and Therapy vol. 21 , ( 1 )
Grigoriadou S, Chowdhury F, Pontarini E, Tappuni A, Bowman SJ, Bombardieri M ( 2019 ) . B-cell depletion with rituximab in the treatment of primary Sjogren's syndrome: what have we learnt? . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 37 , ( 3 ) S217 - S224 .
Giacomelli R, Afeltra A, Alunno A, Bartoloni-Bocci E, Berardicurti O, Bombardieri M, Bortoluzzi A, Caporali R et al. ( 2019 ) . Guidelines for biomarkers in autoimmune rheumatic diseases - evidence based analysis . Autoimmunity Reviews vol. 18 , ( 1 ) 93 - 106 .
Acar-Denizli N, Kostov B, Ramos-Casals M, Brito-Zerón P, Morcillo C, Brito-Zerón P, Flores-Chávez A, Ramos-Casals M et al. ( 2019 ) . The Big Data Sjögren consortium: A project for a new data science era . Clinical and Experimental Rheumatology vol. 37 , S19 - S23 .
Manganelli V, Recalchi S, Capozzi A, Riitano G, Mattei V, Longo A, Franco MD, Alessandri C et al. ( 2018 ) . Autophagy induces protein carbamylation in fibroblast-like synoviocytes from patients with rheumatoid arthritis . Rheumatology (United Kingdom) vol. 57 , ( 11 ) 2032 - 2041 .
Farag A, Papas A, Fisher B, Zeher M, Ng W-F, Bombardieri M, Posch M, Daikeler T et al. ( 2018 ) . Novel Anti-CD40 Monoclonal Antibody CFZ533 in Patients with Primary Sjogren Syndrome: A Phase Iia Double-Blind, Placebo–Controlled Randomized Trial . Oral Surgery Oral Medicine Oral Pathology and Oral Radiology . vol. 126 , e203 - e204 .
Nerviani A, Humby F, Ribera GL, Tan WS, Boutet MA, Goldmann K, Bene F, Hands R et al. ( 2018 ) . Comparative Histologic and Molecular Analysis of Synovial Tissue in Early Treatment-Naive Psoriatic and Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,
Rivellese F, Mauro D, Congia M, Pontarini E, Schafer P, Bombardieri M, Pitzalis C, Lewis MJ ( 2018 ) . Expression and Functions of the Transcription Factors Ikaros and Aiolos in Sjogren's Syndrome and Systemic Lupus Erythematosus . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,
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Astorri E, Lucchesi D, Pitzalis C, Bombardieri M ( 2016 ) . Chapter 7 Spontaneous and Inducible Animal Models of Sjögren’s Syndrome . Sjogren's Syndrome ,
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Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Nerviani A, Rocher-Ros V, Cardus A, Williams AS et al. ( 2015 ) . Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis . Journal of Experimental Medicine vol. 212 , ( 11 ) 1793 - 1802 .
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Bowman S, Everett C, Bombardieri M, Busch R, Emery P, Hall F, Pease CT, Pitzalis C et al. ( 2015 ) . Preliminary Results of a Double-Blind Randomised Trial of Rituximab Anti-B-Cell Therapy in Patients with Primary Sjogrens Syndrome . ARTHRITIS & RHEUMATOLOGY vol. 67 ,
DiCicco M, Humby F, Kelly S, Hands R, Ng N, Mahto A, Lazarou I, Rocher V et al. ( 2015 ) . Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease at 12 Months: Results from the Pathobiology of Early Arthritis Cohort . ARTHRITIS & RHEUMATOLOGY vol. 67 ,
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Humby F, Kelly S, Hands R, Rocher V, DiCicco M, Ng N, Zou L, Bugatti S et al. ( 2015 ) . Use of ultrasound-guided small joint biopsy to evaluate the histopathologic response to rheumatoid arthritis therapy: recommendations for application to clinical trials . Arthritis Rheumatol vol. 67 , ( 10 ) 2601 - 2610 .
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Pontarini E, Lucchesi D, Mavilio D, Bombardieri M ( 2015 ) . AB0169 Recruitment and Activation of NK Cells in the Salivary Glands Regulates Early Viral Control but is Dependable for Autoimmunity and Focal Lymphocytic Sialoadenitis in an Inducible Murine Model of Sjogren-Like Disease . Annals of the Rheumatic Diseases . vol. 74 ,
Astorri E, Croia C, Picarelli G, Sutcliffe N, Tappuni A, Bombardieri M, Priori R ( 2015 ) . AB0565 Routine Investigations for Circulating Igg4 and/or Igg4+ Salivary Gland Histopathology Fail to Reveal Undiagnosed Cases of Igg4 Related Disease in Sicca Patients not Fulfilling the Diagnosis of Sjogren's Syndrome . Annals of the Rheumatic Diseases . vol. 74 ,
Corsiero E, Carlotti E, Pitzalis C, Bombardieri M ( 2015 ) . FRI0007 The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETS)-Citrullinated Autoantigens of Ra Synovial Monoclonal Antibodies . Annals of the Rheumatic Diseases . vol. 74 ,
Carlotti E, Floyd J, Murray-Brown W, Barnes M, Mehr R, Bombardieri M, Pitzalis C ( 2015 ) . FRI0008 Longitudinal Analysis of the IGH-VH Gene by High-Throughput Sequencing in Early Rheumatoid Arthritis Paired Biopsies and its Association with Response to Dmards . Annals of the Rheumatic Diseases . vol. 74 ,
Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Mehr R et al. ( 2015 ) . FRI0020 Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjögren's Syndrome . Annals of the Rheumatic Diseases . vol. 74 ,
Decourcey J, Nerviani A, Melgar S, Bulfone-Paus S, Loscher CE, Bombardieri M, Pitzalis C ( 2015 ) . OP0117 Snare Regulation of TH17 Cells and Ectopic Lymphoid Structure (ELS) Formation in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 74 ,
Nayar S, Campos J, Cloake T, Bowman S, Bombardieri M, Pitzalis C, Luther S, Buckley C et al. ( 2015 ) . SAT0005 IL22 Regulates Autoantibody Production by Inducing Lymphoid Chemokine Expression in Tertiary Lymphoid Organs . Annals of the Rheumatic Diseases . vol. 74 ,
Nerviani A, Humby F, Kelly S, Bombardieri M, Pitzalis C ( 2015 ) . THU0033 A Functional Inhibitory Role for the GAS6/MERTK Axis in Modulating Synovial Inflammation in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 74 ,
Weller ML, Gardener MR, Bogus ZC, Smith MA, Astorri E, Michael DG, Michael DA, Zheng C et al. ( 2015 ) . Hepatitis Delta Virus Detected in Salivary Glands of Sjogren's Syndrome Patients and Induces a Sjogren's Syndrome Phenotype in vivo . SCANDINAVIAN JOURNAL OF IMMUNOLOGY . vol. 81 , 427 - 427 .
Nayar S, Campos J, Cloake T, Bowman S, Bombardieri M, Pitzalis C, Luther S, Buckley C et al. ( 2015 ) . IL22 Regulates Autoantibody Production by Inducing Lymphoid Chemokine Expression in Tertiary Lymphoid Organs . SCANDINAVIAN JOURNAL OF IMMUNOLOGY . vol. 81 , 425 - 425 .
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Pontarini E, Lucchesi D, Mavilio D, Bombardieri M ( 2015 ) . Recruitment and Activation of NK Cells in the Salivary Glands Regulates Early Viral Control but is Dependable for Autoimmunity and Focal Lymphocytic Sialoadenitis in an Inducible Murine Model of Sjogren-Like Disease . SCANDINAVIAN JOURNAL OF IMMUNOLOGY . vol. 81 , 426 - 426 .
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Kelly S, Humby F, Filer A, Ng N, Di Cicco M, Hands RE, Rocher V, Bombardieri M et al. ( 2015 ) . Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients . Ann Rheum Dis vol. 74 , ( 3 ) 611 - 617 .
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Haas R, Smith J, Rocher-Ros V, Nadkarni S, Montero-Melendez T, D’Acquisto F, Bland EJ, Bombardieri M et al. ( 2015 ) . Lactate regulates metabolic and proinflammatory circuits in control of T cell migration and effector functions . PLoS Biology vol. 13 , ( 7 )
Corsiero E, Sutcliffe N, Pitzalis C, Bombardieri M, Reddy J ( 2014 ) . Accumulation of self-reactive naïve and memory B cell reveals sequential defects in B cell tolerance checkpoints in Sjögren's Syndrome . PLoS ONE vol. 9 , ( 12 )
Corsiero E, Bombardieri M, Carlotti E, Pratesi F, Robinson W, Migliorini P, Pitzalis C ( 2014 ) . Citrullinated histones from neutrophil extracellular traps (NETs) fuel ectopic germinal centre responses and ACPA production in rheumatoid joints . IMMUNOLOGY vol. 143 , 43 - 43 .
Pontarini E, Lucchesi D, Bombardieri M, Mavilio D ( 2014 ) . Recruitment and activation of NK cells regulates early immune responses to viral infection in the salivary glands of an inducible murine model of Sjogren-like disease . IMMUNOLOGY vol. 143 , 93 - 93 .
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Di Cicco M, Kelly S, Humby F, Ng N, Nerviani A, Rocher V, Hands R, Bombardieri M et al. ( 2014 ) . SAT0048 Synovial Lymphocytic Aggregates Predict Clinical Response to Certolizumab Pegol in Rheumatoid Arthritis (Clinical and Pathological Response to Certolizumab-Pegol (Clip-Cert) Study) . Annals of the Rheumatic Diseases . vol. 73 ,
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Astorri E, Scrivo R, Bombardieri M, Picarelli G, Pecorella I, Porzia A, Valesini G, Priori R ( 2014 ) . CX3CL1 and CX3CR1 expression in tertiary lymphoid structures in salivary gland infiltrates: fractalkine contribution to lymphoid neogenesis in Sjogren's syndrome . Rheumatology (Oxford) vol. 53 , ( 4 ) 611 - 620 .
Lucchesi D, Pitzalis C, Bombardieri M ( 2014 ) . EBV and other viruses as triggers of tertiary lymphoid structures in primary Sjögren's syndrome . Expert Rev Clin Immunol vol. 10 , ( 4 ) 445 - 455 .
Bombardieri M ( 2014 ) . I3. Future Therapeutic Approaches . Rheumatology vol. 53 , ( suppl_1 ) i1 - i1 .
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Kam YNW, Filer A, Buckley CD, Pitzalis C, Bombardieri M ( 2013 ) . Secretory Leukocyte Protease Inhibitor Released By Rheumatoid Synovial Fibroblasts Exerts a Negative Control Of BAFF-Dependent B Cell Activation In Vitro and In Vivo In The Collagen-Induced and Chimeric RA/SCID Arthritis Models . ARTHRITIS AND RHEUMATISM . vol. 65 , S1029 - S1029 .
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Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Rocher V, Williams AS, Pitzalis C, Jenkins BJ et al. ( 2013 ) . Interleukin-27 as a novel antagonist of ectopic lymphoid-like structure development in early inflammatory arthritis . CYTOKINE . vol. 63 , 274 - 274 .
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Lendrem D, Mitchell S, McMeekin P, Bowman S, Price E, Pease CT, Emery P, Andrews J et al. ( 2013 ) . Health-related utility values of patients with primary Sjögren's syndrome and its predictors . Annals of the Rheumatic Diseases
Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . AB0022 Accumulation of circulating autoreactive naïve b cells reveal defects of early b cell tolerance checkpoints in patients with sjögren’s syndrome . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )
Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . AB0044 Analysis of recombinant monoclonal antibodies from single B cells reveals early defects of B cell tolerance checkpoints in patients with sjÖgren’s syndrome . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )
Kam NW, Bombardieri M, Filter A, Buckley C, Pitzalis C ( 2013 ) . AB0099 Aberrant basal and TLR-stimulated expression of TSLP in rheumatoid synovial fibroblasts . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )
Croia C, Bombardieri M, Serafini B, Humby F, Migliorini P, Aloisi F, Pitzalis C ( 2013 ) . AB0155 Anti-VCA and EBNA1 antibodies are produced in the rheumatoid synovium in the presence of ectopic lymphoid structures and correlate with ACPA production . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )
Spinelli FR, Truglia S, Alessandri C, Bombardieri M, Ceccarelli F, Martinelli F, Miranda F, Conti V et al. ( 2013 ) . AB0200 High expression of toll like receptors 7 and interleukin 18 in lupus nephritis . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )
Murray-Brown W, Picarelli G, Vartoukian S, Sutcliffe N, Fortune F, Valesini G, Pitzalis C, Tappuni A et al. ( 2013 ) . AB0222 Monocyte-derived IL-32 expression correlates with the level of inflammation in salivary glands of sjÖgren’s syndrome . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )
Ng N, Humby F, Kelly S, Di Cicco M, Dadoun S, Bombardieri M, Hands R, Rocher V et al. ( 2013 ) . AB0247 Rheumatoid arthritis patient characteristics at different therapeutic timepoints . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )
Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEAL DEFECTS OF EARLY B CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 792 - 792 .
Croia C, Serafini B, Tappuni A, Aloisi F, Sutcliffe N, Pitzalis C, Bombardieri M ( 2013 ) . ECTOPIC LYMPHOID STRUCTURES SUPPORT EPSTEIN-BARR VIRUS PERSISTENCE AND AUTOREACTIVE PLASMA CELL INFECTION IN SJOGREN'S SYNDROME SALIVARY GLANDS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 462 - 462 .
Ng W-F, Lendrem D, Mitchell S, Bowman S, Price E, Pease C, Emery P, Andrews J et al. ( 2013 ) . EVALUATING HEALTH STATUS OF 620 PATIENTS WITH PRIMARY SJOGREN'S SYNDROME USING EQ-5D . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , 466 - 466 .
Astorri E, Scrivo R, Bombardieri M, Picarelli G, Pecorella I, Porzia A, Valesini G, Priori R ( 2013 ) . EXPRESSION OF FRACTALKINE IN SJOGREN'S SYNDROME PATIENTS: CELLULAR AND MOLECULAR CHARACTERIZATION OF CX3CL1 AND CX3CR1 IN SERA AND SALIVARY GLANDS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 78 - 78 .
Croia C, Serafini B, Tappuni A, Aloisi F, Sutcliffe N, Pitzalis C, Bombardieri M ( 2013 ) . FRI0259 Ectopic lymphoid structures support epstein-barr virus persistence and autoreactive plasma cell infection in sjogren’s syndrome salivary glands . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )
Ng W-F, Miller A, Bowman S, Price E, Kitas G, Pease C, Emery P, Lanyon P et al. ( 2013 ) . FRI0323 Level of physical activity in primary sjögren’s syndrome and its predictors . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )
Ng W-F, Mitchell S, Lendrem D, Bowman S, Price E, Pease C, Emery P, Andrews J et al. ( 2013 ) . HOW GOOD ARE THE EULAR SJOGREN'S SYNDROME DISEASE ACTIVITY INDEX (ESSDAI), AND EULAR SJOGREN'S SYNDROME PATIENTS REPORTED INDEX (ESSPRI) IN PREDICTING HEALTH STATUS IN PRIMARY SJOGREN'S SYNDROME? . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , 553 - 554 .
Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Pitzalis C, Bombardieri M ( 2013 ) . LESIONAL IL-21 EXPRESSION CORRELATES WITH FUNCTIONAL GERMINAL CENTER FORMATION AND T FOLLICULAR HELPER CELL INFILTRATION IN THE SALIVARY GLANDS OF SJOGREN'S SYNDROME . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 77 - 77 .
Ng W-F, Miller A, Bowman S, Price E, Kitas G, Pease C, Emery P, Lanyon P et al. ( 2013 ) . LEVEL OF PHYSICAL ACTIVITY IN PRIMARY SJOGREN'S SYNDROME AND ITS PREDICTORS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 483 - 484 .
Bombardieri M, Rocher V, Mittereder N, Carlesso G, Herbst R, Sleeman M, Pitzalis C ( 2013 ) . MAVRILIMUMAB REDUCES PRO-INFLAMMATORY CYTOKINES AND CD68 POSITIVE MACROPHAGES IN SYNOVIAL EXPLANTS FROM RHEUMATOID ARTHRITIS SUBJECTS ENGRAFTED INTO SCID/BEIGE MICE . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 156 - 157 .
Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Pitzalis C, Bombardieri M ( 2013 ) . OP0080 Lesional IL-21 Expression Correlates with Functional Germinal Center Formation and T Follicular Helper Cell Infiltration in the Salivary Glands of Sjögren’s Syndrome . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )
Astorri E, Scrivo R, Bombardieri M, Picarelli G, Pecorella I, Porzia A, Valesini G, Priori R ( 2013 ) . OP0082 Expression of Fractalkine in Sjögren’s Syndrome Patients: Cellular and Molecular Characterization of CX3CL1 and CX3CR1 in Sera and Salivary Glands . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )
Bombardieri M, Rocher V, Mittereder N, Carlesso G, Herbst R, Sleeman M, Pitzalis C ( 2013 ) . OP0303 Mavrilimumab Reduces Pro-Inflammatory Cytokines and CD68 Positive Macrophages in Synovial Explants from Rheumatoid Arthritis Subjects Engrafted Into SCID/Beige Mice . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )
Ng N, Humby F, Kelly S, Di Cicco M, Dadoun S, Bombardieri M, Hands R, Rocher V et al. ( 2013 ) . RHEUMATOID ARTHRITIS PATIENT CHARACTERISTICS AT DIFFERENT THERAPEUTIC TIMEPOINTS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 862 - 862 .
Deidda S, Humby F, Kelly S, Di Cicco M, Ng N, Hands R, Bombardieri M, Pitzalis C ( 2013 ) . SAT0014 Synovial Sublining Macrophages: A Sensitive Biomarker for Response to Treatment in Early RA Patients . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )
Tarn J, Mitchell S, Bowman S, Price E, Pease C, Sutcliffe N, Emery P, Andrews J et al. ( 2013 ) . SERUM CYTOKINE AND CHEMOKINE PROFILING IN PRIMARY SJOGREN'S SYNDROME . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , 527 - 528 .
Di Cicco M, Dadoun S, Humby F, Kelly S, Ng N, Hands RE, Buckley C, McInnes I et al. ( 2013 ) . SYNOVIAL ECTOPIC LYMPHOID-LIKE STRUCTURES ARE ASSOCIATED WITH DIAGNOSIS OF RHEUMATOID ARTHRITIS, DISEASE ACTIVITY AND ANTIBODY STATUS IN EARLY ARTHRITIS PATIENTS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 192 - 192 .
Deidda S, Humby F, Kelly S, Di Cicco M, Ng N, Hands R, Bombardieri M, Pitzalis C ( 2013 ) . SYNOVIAL SUBLINING MACROPHAGES: A SENSITIVE BIOMARKER FOR RESPONSE TO TREATMENT IN EARLY RA PATIENTS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 583 - 584 .
Di Cicco M, Dadoun S, Humby F, Kelly S, Ng N, Hands RE, Buckley C, McInnes I et al. ( 2013 ) . THU0087 Synovial Ectopic Lymphoid-like Structures are Associated with Diagnosis of Rheumatoid Arthritis, Disease Activity and Antibody Status in Early Arthritis Patients . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )
Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEALS DEFECTS OF EARLY B-CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME . RHEUMATOLOGY . vol. 52 , 159 - 159 .
Patel HB, Bombardieri M, Pitzalis C, Perretti M ( 2013 ) . Activation of Melanocortin Receptor 3 as a new strategy to control experimental and rheumatoid arthritis . FASEB JOURNAL . vol. 27 ,
Ng N, Humby F, Bombardieri M, Kelly S, Di Cicco M, Dadoun S, Hands R, Rocher V et al. ( 2013 ) . CLINICAL, IMAGING AND HISTOLOGICAL CHARACTERISTICS OF PATIENTS WITH RHEUMATOID ARTHRITIS AT DIFFERENT STAGES OF DISEASE PROGRESSION . RHEUMATOLOGY . vol. 52 , 71 - 71 .
Kam NW, Filter A, Buckley C, Pitzalis C, Bombardieri M ( 2013 ) . MEMBRANE-BOUND AND SOLUBLE BAFF EXPRESSION BY HUMAN RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTES IN RESPONSE TO TLR STIMULATION . RHEUMATOLOGY . vol. 52 , 80 - 80 .
Di Cicco M, Humby F, Kelly S, Ng N, Hands R, Dadoun S, Buckley C, McInnes IB et al. ( 2013 ) . SYNOVIAL LYMPHOCYTE AGGREGATES IN EARLY INFLAMMATORY ARTHRITIS: CORRELATION WITH DIAGNOSIS, DISEASE ACTIVITY AND ANTIBODY STATUS . RHEUMATOLOGY . vol. 52 , 29 - 29 .
Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . Accumulation of Circulating Autoreactive Naive B Cells Reveal Defects of Early B Cell Tolerance Checkpoints in Patients with Sjogren's Syndrome . ANNALS OF THE RHEUMATIC DISEASES . vol. 72 , A30 - A31 .
Lucchesi D, Bombardieri M, Barone F, Nayar S, Proctor G, Buckley CD, Pitzalis C ( 2013 ) . INDUCIBLE TERTIARY LYMPHOID STRUCTURES AND AUTOIMMUNITY IN A NOVEL MODEL OF SIALOADENITIS IN WILD-TYPE MICE . ANNALS OF THE RHEUMATIC DISEASES . vol. 72 , A42 - A42 .
Kam NW, Filer A, Buckley C, Bombardieri M, Pitzalis C ( 2013 ) . MEMBRANE-BOUND AND SOLUBLE BAFF EXPRESSION BY HUMAN RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTES IN RESPONSE TO TLR STIMULATION . ANNALS OF THE RHEUMATIC DISEASES . vol. 72 , A38 - A38 .
Croia C, Serafini B, Bombardieri M, Kelly S, Humby F, Severa M, Rizzo F, Coccia EM et al. ( 2013 ) . SYNOVIAL LYMPHOID STRUCTURES SUPPORT EPSTEIN-BARR VIRUS PERSISTENCE AND AUTOREACTIVE PLASMA CELL INFECTION IN RHEUMATOID ARTHRITIS . ANNALS OF THE RHEUMATIC DISEASES . vol. 72 , A43 - A44 .
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Ciccia F, Rizzo A, Accardo-Palumbo A, Giardina A, Bombardieri M, Guggino G, Taverna S, Leo GD et al. ( 2012 ) . Increased expression of interleukin-32 in the inflamed ileum of ankylosing spondylitis patients . Rheumatology (Oxford) vol. 51 , ( 11 ) 1966 - 1972 .
Bombardieri M, Barone F, Lucchesi D, Nayar S, van den Berg WB, Proctor G, Buckley CD, Pitzalis C ( 2012 ) . Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of salivary gland inflammation in C57BL/6 mice . J Immunol vol. 189 , ( 7 ) 3767 - 3776 .
Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2012 ) . Accumulation of circulating autoreactive naive B cells reveal defects of early B cell tolerance checkpoints in patients with Sjogren's syndrome . IMMUNOLOGY . vol. 137 , 327 - 327 .
Jones GW, Greenhill CJ, Williams AS, Nowell MA, Bombardieri M, Pitzalis C, Jenkins BJ, Jones SA ( 2012 ) . IL-27 control of ectopic lymphoid structures in inflammatory arthritis . IMMUNOLOGY . vol. 137 , 44 - 44 .
Lucchesi D, Bombardieri M, Barone F, Nayar S, Proctor G, Buckley CD, Pitzalis C ( 2012 ) . Inducible tertiary lymphoid structures formation in a novel model of sialoadenitis in wild-type mice is preceded by ectopic expression of lymphoid chemokines . IMMUNOLOGY . vol. 137 , 189 - 189 .
Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Pitzalis C, Bombardieri M ( 2012 ) . Lesional IL-21 expression correlates with functional germinal center formation and T follicular helper cell infiltration in the salivary glands of Sjogren's syndrome . IMMUNOLOGY . vol. 137 , 491 - 491 .
Kam NW, Filer A, Buckley C, Bombardieri M, Pitzalis C ( 2012 ) . Membrane-bound and soluble BAFF expression by human rheumatoid fibroblast-like synoviocytes in response to TLR stimulation . IMMUNOLOGY . vol. 137 , 583 - 584 .
Bombardieri M, Pitzalis C ( 2012 ) . Ectopic lymphoid neogenesis and lymphoid chemokines in Sjogren's syndrome: at the interplay between chronic inflammation, autoimmunity and lymphomagenesis . Curr Pharm Biotechnol vol. 13 , ( 10 ) 1989 - 1996 .
Corsiero E, Bombardieri M, Manzo A, Bugatti S, Uguccioni M, Pitzalis C ( 2012 ) . Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases . Immunol Lett vol. 145 , ( 1-2 ) 62 - 67 .
Croia C, Bombardieri M, Francesca A, Serafini B, Humby F, Kelly S, Migliorini P, Pitzalis C ( 2012 ) . ANTI-VCA AND EBNA1 ANTIBODIES ARE PRODUCED IN THE RHEUMATOID SYNOVIUM IN THE PRESENCE OF ECTOPIC LYMPHOID STRUCTURES AND CORRELATE WITH ACPA PRODUCTION . RHEUMATOLOGY . vol. 51 , 43 - 43 .
Nayar S, Cloake T, Bombardieri M, Pitzalis C, Buckley C, Barone F ( 2012 ) . ECTOPIC LYMPHONEOGENESIS IN A NOVEL MURINE MODEL OF SALIVARY GLANDS SIALOADENITIS IS CHARACTERIZED BY ASYNCHRONY IN THE LYMPHANGIOGENETIC AND ANGIOGENETIC PROGRAM . RHEUMATOLOGY . vol. 51 , 143 - 144 .
Lendrem D, Mitchell S, Bowman S, Price E, Pease CT, Emery P, Andrews J, Bombardieri M et al. ( 2012 ) . EVALUATING HEALTH STATUS OF 620 PATIENTS WITH PRIMARY SJOGREN'S SYNDROME USING EQ-5D . RHEUMATOLOGY . vol. 51 , 171 - 171 .
Lendrem D, Mitchell S, Bowman S, Price E, Pease CT, Emery P, Andrews J, Bombardieri M et al. ( 2012 ) . HOW GOOD ARE THE EULAR SJOGREN'S SYNDROME DISEASE ACTIVITY INDEX, AND EULAR SJOGREN'S SYNDROME PATIENTS REPORTED INDEX IN PREDICTING HEALTH STATUS IN PRIMARY SJOGREN'S SYNDROME? . RHEUMATOLOGY . vol. 51 , 176 - 176 .
Whitehead MA, Bombardieri M, Pitzalis C, Vanhaesebroeck B ( 2012 ) . Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter . Biochem J vol. 443 , ( 3 ) 857 - 867 .
Murray-Brown W, Priori R, Tappuni T, Vartoukian S, Seoudi N, Picarelli G, Fortune F, Valesini G et al. ( 2012 ) . MONOCYTE-DERIVED IL-32 EXPRESSION CORRELATES WITH THE LEVEL OF INFLAMMATION IN SALIVARY GLANDS OF SJOGREN'S SYNDROME . RHEUMATOLOGY . vol. 51 , 176 - 176 .
Vila J, Mitchell S, Bowman S, Price E, Pease CT, Emery P, Andrews J, Bombardieri M et al. ( 2012 ) . THE CLINICAL RELEVANCE OF ANTI-RO52 AND ANTI-RO60 IN PATIENTS IN THE UNITED KINGDOM PRIMARY SJOGREN'S SYNDROME REGISTRY (UKPSSR) . RHEUMATOLOGY . vol. 51 , 35 - 35 .
DiCicco M, Humby F, Kelly S, Hands R, Buckley C, McInnes I, Taylor P, Bombardieri M et al. ( 2012 ) . THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT: A PRELIMINARY ANALYSIS CORRELATING HISTOMORPHOLOGY AND DISEASE ACTIVITY . RHEUMATOLOGY . vol. 51 , 149 - 149 .
Kelly S, Bombardieri M, Humby F, Ng N, Di Cicco M, Hands R, Epis O, Filer A et al. ( 2012 ) . ULTRASOUND GUIDED SYNOVIAL BIOPSIES: SAFETY, TOLERABILITY, AND TISSUE QUALITY . RHEUMATOLOGY . vol. 51 , 68 - 68 .
Kam NW, Bombardieri M, Filer A, Buckley C, Pitzalis C ( 2011 ) . Aberrant basal and TLR-stimulated expression of TSLP in rheumatoid synovial fibroblasts . IMMUNOLOGY . vol. 135 , 125 - 125 .
Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2011 ) . Analysis of recombinant monoclonal antibodies from single B cells reveals early defects of B cell tolerance checkpoints in patients with Sjogren's syndrome . IMMUNOLOGY . vol. 135 , 72 - 72 .
Nayar S, Barone F, Choy P, Chang M-M, Bombardieri M, Lucchesi D, Pitzalis C, Buckley C ( 2011 ) . Ectopic lymphoneogenesis in a novel murine model of salivary glands sialoadenitis is characterized by asynchrony in the lymphangiogenetic and angiogenetic program . IMMUNOLOGY . vol. 135 , 49 - 49 .
Bombardieri M, Lucchesi D, Barone F, Nayar S, Proctor G, Buckley CD, Pitzalis C ( 2011 ) . Inducible functional tertiary lymphoid structures, autoimmunity and exocrine dysfunction in wild-type mouse salivary glands via local adenoviral delivery . IMMUNOLOGY . vol. 135 , 167 - 167 .
Bombardieri M, Kam N-W, Brentano F, Choi K, Filer A, Kyburz D, McInnes IB, Gay S et al. ( 2011 ) . A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells . Ann Rheum Dis vol. 70 , ( 10 ) 1857 - 1865 .
Bombardieri M, Kam YNW, Filer A, Buckley CD, Pitzalis C ( 2011 ) . Aberrant Basal and TLR-Stimulated Expression of TSLP in Rheumatoid Synovial Fibroblasts . ARTHRITIS AND RHEUMATISM . vol. 63 , S140 - S140 .
Croia C, Bombardieri M, Serafini B, Coccia EM, Severa M, Kelly S, Aloisi F, Pitzalis C ( 2011 ) . EBV Infection In the Rheumatoid Synovium: Relationship with Ectopic Lymphoid Structures, In Situ Autoantobody Production and CD8 T Cell Activation . ARTHRITIS AND RHEUMATISM . vol. 63 , S140 - S140 .
Bugatti S, Manzo A, Bombardieri M, Vitolo B, Humby F, Kelly S, Montecucco C, Pitzalis C ( 2011 ) . Synovial Tissue Heterogeneity and Peripheral Blood Biomarkers . CURRENT RHEUMATOLOGY REPORTS vol. 13 , ( 5 ) 440 - 448 .
Marrelli A, Bombardieri M, Kelly S, Cipriani P, Giacomelli R, Pitzalis C ( 2011 ) . DIGITAL IMAGE ANALYSIS FOR THE EVALUATION OF BLOOD VESSEL DENSITY IN RHEUMATOID SYNOVIUM: CORRELATION WITH QUANTITATIVE REAL-TIME PCR EXPRESSION OF ENDOTHELIAL ANTIGEN AND ANGIOGENIC GROWTH FACTORS . RHEUMATOLOGY . vol. 50 , 75 - 75 .
Croia C, Serafini B, Bombardieri M, Kelly S, Coccia EM, Severa M, Francesca A, Pitzalis C ( 2011 ) . EBV INFECTION IN THE RHEUMATOID ARTHRITIS SYNOVIUM: RELATIONSHIP TO ECTOPIC LYMPHOID STRUCTURES AND CD8 T CELL ACTIVATION . RHEUMATOLOGY . vol. 50 , 75 - 75 .
Bombardieri M ( 2011 ) . HOW WILL B-CELL BASIC SCIENCE RESEARCH DRIVE TREATMENT IN SJOGREN'S SYNDROME? . RHEUMATOLOGY . vol. 50 , 12 - 13 .
Priori R, Barone F, Alessandri C, Colafrancesco S, McInnes IB, Pitzalis C, Valesini G, Bombardieri M ( 2011 ) . Markedly increased IL-18 liver expression in adult-onset Still's disease-related hepatitis . Rheumatology (Oxford) vol. 50 , ( 4 ) 776 - 780 .
Mahoney DJ, Swales C, Athanasou NA, Bombardieri M, Pitzalis C, Kliskey K, Sharif M, Day AJ et al. ( 2011 ) . TSG-6 Inhibits Osteoclast Activity via an Autocrine Mechanism and Is Functionally Synergistic With Osteoprotegerin . ARTHRITIS RHEUM-US vol. 63 , ( 4 ) 1034 - 1043 .
Rajak R, Amos N, Camilleri J, Charles PJ, Plant D, Chowdhury M, Worthington J, Venables P et al. ( 2011 ) . Rheumatoid arthritis - aetiopathogenesis and animal models87. Do We Need to Redefine Seropositivity in RA? . Rheumatology vol. 50 , ( suppl_3 ) iii74 - iii76 .
Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C ( 2011 ) . EVOLUTION OF ECTOPIC LYMPHOID NEOGENESIS AND IN SITU AUTOANTIBODIES PRODUCTION IN AUTOIMMUNE DIABETIC NOD MICE: CELLULAR AND MOLECULAR CHARACTERISATION OF TERTIARY LYMPHOID STRUCTURES IN PANCREATIC ISLETS . ANNALS OF THE RHEUMATIC DISEASES . vol. 70 ,
Patel HB, Bombardieri M, Sampaio ALF, D'Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C et al. ( 2010 ) . Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis . FASEB J vol. 24 , ( 12 ) 4835 - 4843 .
Corsiero E, Bombardieri M, Humby F, Manzo A, Kelly S, Pitzalis C ( 2010 ) . Characterization of inter follicular large B cells, a new subpopulation of B lymphocytes, in tertiary lymphoid organs in rheumatic autoimmune diseases . IMMUNOLOGY . vol. 131 , 33 - 33 .
Astorri E, Guglielmi C, Bombardieri M, Alessandri C, Buzzetti R, Maggi D, Valesini G, Pitzalis C et al. ( 2010 ) . Circulating Reg1α proteins and autoantibodies to Reg1α proteins as biomarkers of β-cell regeneration and damage in type 1 diabetes . Horm Metab Res vol. 42 , ( 13 ) 955 - 960 .
Croia C, Serafini B, Bombardieri M, Kelly S, Coccia EM, Severa M, Aloisi F, Pitzalis C ( 2010 ) . EBV infection in the rheumatoid arthritis synovium: relationship to tertiary lymphoid structures and CD8 T cell activation . IMMUNOLOGY . vol. 131 , 124 - 124 .
Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C ( 2010 ) . Evolution of ectopic lymphoid neogenesis and in-situ autoantibodies production in autoimmune diabetic NOD mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islet . IMMUNOLOGY . vol. 131 , 63 - 63 .
Ciccia F, Accardo-Palumbo A, Giardina A, Di Maggio P, Principato A, Bombardieri M, Rizzo A, Alessandro R et al. ( 2010 ) . Expansion of Intestinal CD4+CD25(high) Treg Cells in Patients With Ankylosing Spondylitis A Putative Role for Interleukin-10 in Preventing Intestinal Th17 Response . ARTHRITIS RHEUM-US vol. 62 , ( 12 ) 3625 - 3634 .
Hendler A, Mulli TK, Hughes FJ, Perrett D, Bombardieri M, Houri-Haddad Y, Weiss EI, Nissim A ( 2010 ) . Involvement of autoimmunity in the pathogenesis of aggressive periodontitis . Journal of Dental Research vol. 89 , ( 12 ) 1389 - 1394 .
Lucchesi D, Astorri E, Bombardieri M, Corsiero E, Barone F, Proctor G, Pitzalis C ( 2010 ) . Molecular and cellular evolution of functional tertiary lymphoid structures in salivary glands of NOD mice . IMMUNOLOGY . vol. 131 , 59 - 59 .
Kam NW, Bombardieri M, Brentano F, Choi K, Kyburz D, Gay S, Mclnnes IB, Pitzalis C ( 2010 ) . Rheumatoid synovial fibroblasts support AID expression and Ig class-switching in B cells via a Baff-dependent TLR3-stimulated pathway . IMMUNOLOGY . vol. 131 , 71 - 71 .
Ciccia F, Bombardieri M, Rizzo A, Principato A, Giardina AR, Raiata F, Peralta S, Ferrante A et al. ( 2010 ) . Over-expression of paneth cell-derived anti-microbial peptides in the gut of patients with ankylosing spondylitis and subclinical intestinal inflammation . Rheumatology (Oxford) vol. 49 , ( 11 ) 2076 - 2083 .
Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C ( 2010 ) . Evolution of ectopic lymphoid neogenesis and in situ autoantibody production in autoimmune nonobese diabetic mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islets . J Immunol vol. 185 , ( 6 ) 3359 - 3368 .
Patel HB, Bombardieri M, Sampaio ALF, D’Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C et al. ( 2010 ) . Anti‐inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis . The FASEB Journal vol. 24 , ( 12 ) 4835 - 4843 .
Mahoney DJ, Swales C, Athanasou N, Bombardieri M, Pitzalis C, Kliskey K, Sharif M, Day A et al. ( 2010 ) . TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with OPG . Bone vol. 47 ,
Astorri E, Bombardieri M, Corsiero E, Gabba S, Barone F, Proctor G, Pitzalis C ( 2010 ) . MOLECULAR AND CELLULAR EVOLUTION OF FUNCTIONAL TERTIARY LYMPHOID STRUCTURES IN SALIVARY GLANDS OF NOD MICE . RHEUMATOLOGY . vol. 49 , I28 - I28 .
Bombardieri M, Kam YNW, Brentano F, Choi K, Kyburz D, Gay S, McInnes IB, Pitzalis C ( 2010 ) . RHEUMATOID SYNOVIAL FIBROBLASTS SUPPORT AID EXPRESSION AND IG CLASS-SWITCHING IN B CELLS VIA A BAFF-DEPENDENT TLR3-STIMULATED PATHWAY . RHEUMATOLOGY . vol. 49 , I26 - I27 .
Swales C, Mahoney DJ, Athanasou NA, Bombardieri M, Pitzalis C, Sharif O, Day AJ, Milner CM et al. ( 2010 ) . TSG-6: AN AUTOCRINE REGULATOR OF INFLAMMATORY JOINT DISEASE? . RHEUMATOLOGY . vol. 49 , I27 - I27 .
Bombardieri M, Astorri E, Corsiero E, Gabba S, Barone F, Proctor G, Pitzalis C ( 2010 ) . MOLECULAR AND CELLULAR EVOLUTION OF FUNCTIONAL TERTIARY LYMPHOID STRUCTURES IN SALIVARY GLANDS OF NOD MICE . ANNALS OF THE RHEUMATIC DISEASES . vol. 69 ,
Manzo A, Bombardieri M, Humby F, Pitzalis C ( 2010 ) . Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling . IMMUNOL REV vol. 233 , 267 - 285 .
Priori R, Alessandri C, Magrini L, Cassara EAM, Ceccarelli F, Modesti M, Croia C, Bombardieri M et al. ( 2009 ) . Nucleosome accumulation and reduction of C-reactive protein are associated with the generation of anti-nuclear antibodies in patients with rheumatoid arthritis treated with adalimumab, but not with etanercept . ANN RHEUM DIS vol. 68 , ( 9 ) 1514 - 1516 .
Patel HB, Bombardieri M, Pitzalis C, Perretti M ( 2009 ) . Activation of melanocortin receptor type 3 as a new strategy to control experimental and rheumatoid arthritis . EUR J CLIN INVEST vol. 39 , 29 - 29 .
Bombardieri M, Ciccia F, Principato A, Tripodo C, Peralta S, Triolo G, Pitzalis C ( 2009 ) . IL-23 OVEREXPRESSION AS IMMUNOLOGICAL SIGNATURE OF SUBCLINICAL INTESTINAL INFLAMMATION IN ANKYLOSING SPONDYLITIS . RHEUMATOLOGY . vol. 48 , I6 - I6 .
Ciccia F, Bombardieri M, Principato A, Giardina A, Tripodo C, Porcasi R, Peralta S, Franco V et al. ( 2009 ) . Overexpression of Interleukin-23, but Not Interleukin-17, as an Immunologic Signature of Subdinical Intestinal Inflammation in Ankylosing Spondylitis . ARTHRITIS RHEUM vol. 60 , ( 4 ) 955 - 965 .
Conigliaro P, Priori R, Bombardieri M, Alessandri C, Barone F, Pitzalis C, McInnas IB, Valesini G ( 2009 ) . Lymph node IL-18 expression in adult-onset Still's disease . Annals of the Rheumatic Diseases vol. 68 , ( 3 ) 442 - 443 .
Humby F, Bombardieri M, Manzo A, Kelly S, Blades MC, Kirkham B, Spencer J, Pitzalis C ( 2009 ) . Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium . PLoS Med vol. 6 , ( 1 )
Guglielmi C, Astorri E, Portuesi R, Bombardieri M, Valorani M, Pozzilli P ( 2008 ) . A diet rich in protein and poor in starch with reduced food intake prevents diabetes in the NOD moose: the significance of Reg gene expression in the pancreas . DIABETOLOGIA vol. 51 , S229 - S229 .
Astorri E, Bombardieri M, Guglielmi C, Pitzalis C, Pozzilli P ( 2008 ) . Beta cell regeneration in type 1 diabetes: the role of Reg genes in NOD mice . DIABETOLOGIA vol. 51 , S186 - S186 .
Humby F, Bombardieri M, Antonio M, Blades M, Bruce K, Spencer J, Pitzalis C ( 2008 ) . Ectopic lymphoid structures expressing AID drive self sustained in situ prodction of autoantibodies in rheumatoid synovium . ARTHRITIS AND RHEUMATISM . vol. 58 , S633 - S634 .
Bombardieri M, Barone F, Humby F, Morgan P, Challacombe S, Spencer J, Pitzalis C ( 2008 ) . Activation-induced cytidine deaminase expression supports functionality of ectopic lymphoid neogenesis in patients with and animal models of Sjogren's syndrome . RHEUMATOLOGY . vol. 47 , II85 - II85 .
Humby F, Bombardieri M, Manzo A, Blades M, Kirkham B, Spencer J, Pitzalis C ( 2008 ) . Activation-induced cytidine deaminase supports self sustained autoantibody production within RA synovium . RHEUMATOLOGY . vol. 47 , II59 - II59 .
Barone F, Bombardieri M, Rosado MM, Morgan PR, Challacombe SJ, De Vita S, Carsetti R, Spencer J et al. ( 2008 ) . CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: Association with reactive and malignant areas of lymphoid organization . J IMMUNOL vol. 180 , ( 7 ) 5130 - 5140 .
Bombardieri M, Barone F, Pitzalis C ( 2008 ) . Response to comment on "Activation-Induced Cyridine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis aud MALT Lymphoma in Sjogren's Syndrome" . J IMMUNOL vol. 180 , ( 4 ) 2008 - 2009 .
Quartuccio L, Fabris M, Moretti M, Barone F, Bombardieri M, Rupolo M, Lombardi S, Pitzalis C et al. ( 2008 ) . Resistance to rituximab therapy and local BAFF overexpression in Sjögren’s syndrome-related myoepithelial sialadenitis and low-grade parotid B-cell lymphoma . Open Rheumatology Journal vol. 2 , 38 - 43 .
Croce A, Firuzi O, Altieri F, Eufemi M, Agostino R, Priori R, Bombardieri M, Alessandri C et al. ( 2007 ) . Effect of infliximab on the glycosylation of IgG of patients with rheumatoid arthritis . Journal of Clinical Laboratory Analysis vol. 21 , ( 5 ) 303 - 314 .
Bombardieri M, Barone F, Humby F, Kelly S, McGurk M, Morgan P, Challacombe S, De Vita S et al. ( 2007 ) . Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjögren's syndrome . J Immunol vol. 179 , ( 7 ) 4929 - 4938 .
Barone F, Bombardieri M, Spencer J, Isaacson P, Humby F, Morgan P, Challacombe S, Valesini G et al. ( 2007 ) . CXCL13, CCL21 and CXCL12 are upregulated in mucosal-associated lymphoid tissue lymphomas in patients with Sjorgen's syndrome and cooperate in the maintenance of the immune response and malignant cell survival . Arthritis research & therapy vol. 9 , ( Suppl 3 ) P15 - P15 .
Bombardieri M, McInnes IB, Pitzalis C ( 2007 ) . Interleukin-18 as a potential therapeutic target in chronic autoimmune/inflammatory conditions . Expert Opinion on Biological Therapy vol. 7 , ( 1 ) 31 - 40 .
Alessandri C, Sorice M, Bombardieri M, Conigliaro P, Longo A, Garofalo T, Manganelli V, Conti F et al. ( 2006 ) . Antiphospholipid reactivity against cardiolipin metabolites occurring during endothelial cell apoptosis . Arthritis Research and Therapy vol. 8 ,
Alessandri C, Bombardieri M, Valesini G ( 2006 ) . Pathogenic Mechanisms Of Anti-Endothelial Cell Antibodies (AECA): Their Prevalence And Clinical Relevance .
Bombardieri M, Barone F, Carlucci F, Proctor G, van de Loo FA, van den Berg WB, Botto M, Valesini G et al. ( 2006 ) . The IL-18/IL-18R axis is significantly up-regulated in submandibular glands in the nod mouse model of Sjogren's syndrome and is associated with an ongoing TH1-mediated inflammation . RHEUMATOLOGY . vol. 45 , I156 - I156 .
Scrivo R, Spadaro A, Riccieri V, Bombardieri M, Di Franco M, Celestino D, Valesini G ( 2005 ) . Soluble P-selectin levels in synovial fluid and serum from patients with psoriatic arthritis . Reumatismo vol. 57 , ( 4 ) 250 - 255 .
PITZALIS C, Manzo A, Bombardieri M, Valesini G, Challacombe SJ, Morgan PR, Barone F, Blades MC ( 2005 ) . Association of CXCL13 and CCL21 Expression With the Progressive Organization of Lymphoid-like Structures in Sjogren’s Syndrome . Arthritis & Rheumatism vol. 52 , ( 6 ) 1773 - 1784 .
Alessandri C, Bombardieri M, Di Prospero L, Conigliaro P, Conti F, Labbadia G, Misasi R, Sorice M et al. ( 2005 ) . Anti-lysobisphosphatidic acid antibodies in patients with antiphospholipid syndrome and systemic lupus erythematosus . Clinical and Experimental Immunology vol. 140 , ( 1 ) 173 - 180 .
Bombardieri M, Barone F, Proctor G, van de Loo FA, van den Berg WB, Valesini G, McInnes IB, Pitzalis C ( 2005 ) . Efficient IL-18 and IL-18BPc adenoviral gene transfer to cultured murine submandibular gland epithelial cells and successful murine retrograde submandibular duct cannulation to modulate IL-18 function in the salivary gland of animal models of Sjogren's syndrome . Arthritis research & therapy vol. 7 , ( Suppl 1 ) P94 - P94 .
Alessandri C, Bombardieri M, Papa N, Cinquini M, Magrini L, Tincani A, Valesini G ( 2004 ) . Decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNFα therapy (infliximab) in rheumatoid arthritis is associated with clinical improvement . Annals of the Rheumatic Diseases vol. 63 , ( 10 ) 1218 - 1221 .
Priori R, Bombardieri M, Spinelli FR, Merlin F, Miceli-Richard C, La Cava M, Scavalli AS, Guerrisi R et al. ( 2004 ) . Sporadic Blau syndrome with a double CARD15 mutation. Report of a case with lifelong follow-up . Sarcoidosis Vasculitis and Diffuse Lung Diseases vol. 21 , ( 3 ) 228 - 231 .
Conti F, Alessandri C, Bompane D, Bombardieri M, Spinelli FR, Rusconi AC, Valesini G ( 2004 ) . Autoantibody profile in systemic lupus erythematosus with psychiatric manifestations: a role for anti-endothelial-cell antibodies . Arthritis research &amp; therapy vol. 6 , ( 4 )
Bombardieri M, Barone F, Pittoni V, Alessandri C, Conigliaro P, Blades MC, Priori R, McInnes IB et al. ( 2004 ) . Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate . Arthritis research &amp; therapy vol. 6 , ( 5 )
Barone F, Bombardieri M, Blades MC, Manzo A, Morgan P, Challacombe S, Valesini G, Pitzalis C ( 2004 ) . Lymphoid chemokine expression in Sjogren's syndrome: relationship with the lymphoid organization of the periductal inflammatory aggregates . Arthritis research & therapy vol. 6 , ( Suppl 3 ) 94 - 94 .
Bombardieri M, Alessandri C, Labbadia G, Iannuccelli C, Carlucci F, Riccieri V, Paoletti V, Valesini G ( 2004 ) . Role of anti-cyclic citrullinated peptide antibodies in discriminating patients with rheumatoid arthritis from patients with chronic hepatitis C infection-associated polyarticular involvement . Arthritis research &amp; therapy vol. 6 , ( 2 )
Spadaro A, Scrivo R, Bombardieri M, Riccieri V, Rinaldi T, Taccari E, Valesini G ( 2003 ) . Relationship of interleukin-12 and interleukin-13 imbalance with class-specific rheumatoid factors and anticardiolipin antibodies in systemic lupus erythematosus . Clinical Rheumatology vol. 22 , ( 2 ) 107 - 111 .
Alessandri C, Bombardieri M, Scrivo R, Viganego F, Conti F, De Luca N, Riccieri V, Valesini G ( 2003 ) . Anti-carbonic anhydrase II antibodies in systemic sclerosis: Association with lung involvement . Autoimmunity vol. 36 , ( 2 ) 85 - 89 .
Pittoni V, Bombardieri M, Spinelli FR, Scrivo R, Alessandri C, Conti F, Spadaro A, Valesini G ( 2002 ) . Anti-tumour necrosis factor (TNF) α treatment of rheumatoid arthritis (infliximab) selectively down regulates the production of interleukin (IL) 18 but not of IL12 and IL13 . Annals of the Rheumatic Diseases vol. 61 , ( 8 ) 723 - 725 .
Ossandon A, Bombardieri M, Coari G, Graziani G, Valesini G ( 2002 ) . Protein losing enteropathy in systemic lupus erythematosus: Role of diet and octreotide [2] . Lupus vol. 11 , ( 7 ) 465 - 466 .