Publications: Prof Karim Brohi

Juffermans NP, Gözden T, Brohi K, Davenport R, Acker JP, Reade MC, Maegele M, Neal MD et al. ( 2024 ) . Transforming research to improve therapies for trauma in the twenty-first century . Critical Care vol. 28 , ( 1 )

Maier CL, Brohi K, Curry N, Juffermans NP, Mora Miquel L, Neal MD, Shaz BH, Vlaar APJ et al. ( 2024 ) . Correction: Contemporary management of major haemorrhage in critical care . Intensive Care Medicine1 - 1 .

Maier CL, Brohi K, Curry N, Juffermans NP, Mora Miquel L, Neal MD, Shaz BH, Vlaar APJ et al. ( 2024 ) . Contemporary management of major haemorrhage in critical care . Intensive Care Medicine1 - 13 .

Van Gent J-M, Kaminski CW, Praestholm C, Pivalizza EG, Clements TW, Kao LS, Stanworth S, Brohi K et al. ( 2023 ) . Empiric Cryoprecipitate Transfusion in Patients with Severe Hemorrhage: Results from The US Experience in the International Cryostat-2 Trial . Journal of the American College of Surgeons

Schofield H, Rossetto A, Armstrong PC, Allan HE, Warner TD, Brohi K, Vulliamy P ( 2023 ) . Immature platelet dynamics are associated with clinical outcomes after major trauma . Journal of Thrombosis and Haemostasis

Dujardin RWG, Kleinveld DJB, van den Brom CE, Geeraedts LMG, Beijer E, Gaarder C, Brohi K, Stanworth S et al. ( 2023 ) . Older females have increased mortality after trauma as compared to younger females and males, associated with increased fibrinolysis . Journal of Trauma and Acute Care Surgery

Schofield H, Lindsay C, Brohi K, Davenport R ( 2023 ) . Group B or Not Group B? An Association Between ABO, Early Mortality, and Organ Dysfunction in Major Trauma Patients with Shock . Journal of Thrombosis and Haemostasis

Badminton R, Christie R, Brohi K, Cole E ( 2023 ) . Pre-injury sarcopenia and the association with discharge destination in critical care trauma patients . Trauma (London, England)

Jansen JO, Hudson J, Cochran C, MacLennan G, Lendrum R, Sadek S, Gillies K, Cotton S et al. ( 2023 ) . Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage . JAMA vol. 330 , ( 19 ) 1862 - 1871 .

Alruqi F, Aglago EK, Cole E, Brohi K ( 2023 ) . Factors Associated With Delayed Pre-Hospital Times During Trauma-Related Mass Casualty Incidents: A Systematic Review . Disaster Medicine and Public Health Preparedness vol. 17 ,

Hannadjas I, James A, Davenport R, Lindsay C, Brohi K, Cole E ( 2023 ) . Prothrombin complex concentrate (PCC) for treatment of trauma-induced coagulopathy: systematic review and meta-analyses . Critical Care vol. 27 , ( 1 )

Gunn F, Stevenson R, Almuwallad A, Rossetto A, Vulliamy P, Brohi K, Davenport R ( 2023 ) . A comparative analysis of tranexamic acid dosing strategies in traumatic major hemorrhage . Journal of Trauma and Acute Care Surgery vol. 96 , ( 2 ) 216 - 224 .

Davenport R, Brohi K, laura G ( 2023 ) . Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury: The CRYOSTAT-2 Randomized Clinical Trial . Journal of the American Medical Association vol. 330 , ( 19 )

Almuwallad A, Cole E, Rossetto A, Brohi K, Perkins Z, Davenport R ( 2023 ) . Nationwide analysis of prehospital tranexamic acid for trauma demonstrates systematic bias in adherence to treatment guidelines: a retrospective cohort study . International Journal of Surgery vol. 109 , ( 12 ) 3796 - 3803 .

Schofield H, Rossetto A, Armstrong PC, Allan HE, Warner TD, Brohi K, Vulliamy P ( 2023 ) . Immature platelet dynamics are associated with clinical outcomes after major trauma .

Dicker R, Brohi K ( 2023 ) . Violence and surgeons . British Journal of Surgery vol. 110 , ( 10 ) 1247 - 1248 .

Shepherd JM, Ross J, Anton L, Rourke C, Brentnall AR, Tarning J, White NJ, Thiemermann C et al. ( 2023 ) . Safety and efficacy of artesunate treatment in severely injured patients with traumatic hemorrhage. The TOP-ART randomized clinical trial . Intensive Care Medicine vol. 49 , ( 8 ) 922 - 933 .

Simpson R, Praditsuktavorn B, Wall J, Morales V, Thiemermann C, Tremoleda JL, Brohi K ( 2023 ) . Myocardial alterations following traumatic hemorrhagic injury . Journal of Trauma and Acute Care Surgery vol. 95 , ( 4 ) 481 - 489 .

Rossetto A, Wohlgemut JM, Brohi K, Davenport R ( 2023 ) . Sonorheometry versus rotational thromboelastometry in trauma: a comparison of diagnostic and prognostic performance . Journal of Thrombosis and Haemostasis vol. 21 , ( 8 ) 2114 - 2125 .

Tucker H, Brohi K, Tan J, Aylwin C, Bloomer R, Cardigan R, Davenport R, Davies ED et al. ( 2023 ) . Association of red blood cells and plasma transfusion versus red blood cell transfusion only with survival for treatment of major traumatic hemorrhage in prehospital setting in England: a multicenter study . Critical Care vol. 27 , ( 1 )

Brohi K ( 2023 ) . Shock, haemorrhage and transfusion . Bailey and Love’s: Short Practice of Surgery: 28th Edition ,

Curry NS, Davenport R, Wong H, Gaarder C, Johansson P, Juffermans NP, Maegele M, Stensballe J et al. ( 2022 ) . Traumatic coagulopathy in the older patient: analysis of coagulation profiles from the Activation of Coagulation and Inflammation in Trauma-2 (ACIT-2) observational, multicenter study . Journal of Thrombosis and Haemostasis vol. 21 , ( 2 ) 215 - 226 .

Dujardin RWG, Kisters JEC, Wirtz MR, Hajji N, Boer AMT-D, Stensballe J, Johansson PI, Brohi K et al. ( 2022 ) . Shock-Driven Endotheliopathy in Trauma Patients Is Associated with Leucocyte Derived Extracellular Vesicles . International Journal of Molecular Sciences vol. 23 , ( 24 )

Curry N, Davenport R, Lucas J, Deary A, Benger J, Edwards A, Evans A, Foley C et al. ( 2022 ) . The CRYOSTAT2 trial: The rationale and study protocol for a multi‐Centre, randomised, controlled trial evaluating the effects of early high‐dose cryoprecipitate in adult patients with major trauma haemorrhage requiring major haemorrhage protocol activation . Transfusion Medicine vol. 33 , ( 2 ) 123 - 131 .

Vulliamy P, Hancorn K, Glasgow S, West A, Davenport R, Brohi K, Griffiths MP ( 2022 ) . Age-related Injury Patterns Resulting from Knife Violence in an Urban Population . Scientific Reports

Vigstedt M, Baksaas-Aasen K, Henriksen HH, Maegele M, Stanworth S, Juffermans NP, Kolstadbråten KM, Naess PA et al. ( 2022 ) . Thrombelastography (TEG® 6s) early amplitudes predict maximum amplitude in severely injured trauma patients . Scandinavian Journal of Clinical and Laboratory Investigation vol. 82 , ( 6 ) 508 - 512 .

Green L, Brohi K, Allen E, Grant-Casey J, Doughty H, Estcourt L, Hearnshaw S, Klein A et al. ( 2022 ) . UK audit of the management of major bleeding and time taken to deliver blood products . British Journal of Anaesthesia vol. 129 , ( 5 ) e111 - e114 .

Sloos PH, Vulliamy P, Veer C, Gupta AS, Neal MD, Brohi K, Juffermans NP, Kleinveld DJB ( 2022 ) . Platelet dysfunction after trauma: From mechanisms to targeted treatment . Transfusion vol. 62 , ( Suppl 1 ) s281 - s300 .

Cole E, Aylwin C, Christie R, Dillane B, Farrah H, Hopkins P, Ryan C, Woodgate A et al. ( 2022 ) . Multiple Organ Dysfunction in Older Major Trauma Critical Care Patients . Annals of Surgery Open vol. 3 , ( 2 ) e174 - e174 .

Moore L, Bérubé M, Tardif P-A, Lauzier F, Turgeon A, Cameron P, Champion H, Yanchar N et al. ( 2022 ) . Quality Indicators Targeting Low-Value Clinical Practices in Trauma Care . JAMA Surgery vol. 157 , ( 6 ) 507 - 514 .

Jansen JO, Cochran C, Boyers D, Gillies K, Lendrum R, Sadek S, Lecky F, MacLennan G et al. ( 2022 ) . The effectiveness and cost-effectiveness of resuscitative endovascular balloon occlusion of the aorta (REBOA) for trauma patients with uncontrolled torso haemorrhage: study protocol for a randomised clinical trial (the UK-REBOA trial) . Trials vol. 23 , ( 1 )

Dujardin RWG, Kleinveld DJB, Gaarder C, Brohi K, Davenport RA, Curry N, Stanworth S, Johansson PI et al. ( 2022 ) . Coagulopathy Underlying Rotational Thromboelastometry Derangements in Trauma Patients: A Prospective Observational Multicenter Study . Anesthesiology vol. 137 , ( 2 ) 232 - 242 .

Byerly S, Nahmias J, Stein DM, Haut ER, Smith JW, Gelbard R, Ziesmann M, Boltz M et al. ( 2022 ) . A core outcome set for damage control laparotomy via modified Delphi method . Trauma Surgery & Acute Care Open vol. 7 , ( 1 )

Brohi K ( 2022 ) . Foreword . Textbook of Acute Trauma Carevii - viii .

Brohi K, Tallach R ( 2021 ) . Mass casualty medicine: time for a 21st century refresh . British Journal of Anaesthesia vol. 128 , ( 2 ) e65 - e67 .

Tallach R, Brohi K ( 2021 ) . Embracing uncertainty in mass casualty incidents . British Journal of Anaesthesia vol. 128 , ( 2 ) e79 - e82 .

Tallach R, Einav S, Brohi K, Abayajeewa K, Abback P-S, Aylwin C, Batrick N, Boutonnet M et al. ( 2021 ) . Learning from terrorist mass casualty incidents: a global survey . British Journal of Anaesthesia vol. 128 , ( 2 ) e168 - e179 .

Elbourne C, Cole E, Marsh S, Rex D, Makin E, Salter R, Brohi K, Edmonds N et al. ( 2021 ) . At risk child: a contemporary analysis of injured children in London and the South East of England: a prospective, multicentre cohort study . BMJ Paediatrics Open vol. 5 , ( 1 )

Rossetto A, Vulliamy P, Lee K, Brohi K, Davenport R ( 2021 ) . Temporal Transitions In Fibrinolysis After Trauma: Adverse Outcome Is Principally Related To Late Hypofibrinolysis­­­­ . Anesthesiology

Vulliamy P, Marsden M, Carden R, Brohi K, Davenport R ( 2021 ) . SP9.1.7 Emergency Laparotomy for Trauma in the United Kingdom and Ireland: a Prospective Multicentre Study . British Journal of Surgery . vol. 108 ,

Kleinveld DJB, Simons DDG, Dekimpe C, Deconinck SJ, Sloos PH, Maas MAW, Kers J, Muia J et al. ( 2021 ) . Plasma and rhADAMTS13 reduce trauma-induced organ failure by restoring the ADAMTS13-VWF axis . Blood Advances vol. 5 , ( 17 ) 3478 - 3491 .

Tucker H, Avery P, Brohi K, Davenport R, Griggs J, Weaver A, Green L ( 2021 ) . Outcome measures used in clinical research evaluating prehospital blood component transfusion in traumatically injured bleeding patients: A systematic review . Journal of Trauma and Acute Care Surgery vol. 91 , ( 6 ) 1018 - 1024 .

McElroy L, Robinson L, Battle C, Laidlaw L, Teager A, de Bernard L, McGillivray J, Tsang K et al. ( 2021 ) . Use of a modified Delphi process to develop research priorities in major trauma . European Journal of Trauma and Emergency Surgery vol. 48 , ( 2 ) 1453 - 1461 .

Johannsen S, Brohi K, Johansson PI, Moore EE, Reinhold A-K, Schöchl H, Shepherd JM, Slater B et al. ( 2021 ) . Getting hit by the bus around the world – a global perspective on goal directed treatment of massive hemorrhage in trauma . Current Opinion in Anaesthesiology vol. 34 , ( 4 ) 537 - 543 .

Qasim Z, Butler FK, Holcomb JB, Kotora JG, Eastridge BJ, Brohi K, Scalea TM, Schwab CW et al. ( 2021 ) . Selective Prehospital Advanced Resuscitative Care – Developing a Strategy to Prevent Prehospital Deaths From Noncompressible Torso Hemorrhage . Shock vol. 57 , ( 1 ) 7 - 14 .

Thaventhiran A, Thiemermann C, Brohi K, Tremoleda J, Davenport R ( 2021 ) . O1: DISCOVERING NOVEL THERAPEUTICS TO TREAT ACUTE TRAUMATIC COAGULOPATHY (ATC) . British Journal of Surgery vol. 108 , ( Supplement_1 )

Roberts DJ, Bobrovitz N, Zygun DA, Kirkpatrick AW, Ball CG, Faris PD, Stelfox HT ( 2021 ) . Evidence for use of damage control surgery and damage control interventions in civilian trauma patients: a systematic review . World Journal of Emergency Surgery vol. 16 , ( 1 )

Holcomb JB, Moore EE, Sperry JL, Jansen JO, Schreiber MA, Del Junco DJ, Spinella PC, Sauaia A et al. ( 2020 ) . Evidence-Based and Clinically Relevant Outcomes for Hemorrhage Control Trauma Trials . Annals of Surgery vol. 273 , ( 3 ) 395 - 401 .

Davenport RA, Green L, Brohi K ( 2020 ) . Cryoprecipitate/Fibrinogen Concentrate Transfusions . Trauma Induced Coagulopathy , Springer Nature

Baksaas-Aasen K, Gall LS, Stensballe J, Juffermans NP, Curry N, Maegele M, Brooks A, Rourke C et al. ( 2020 ) . Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial . Intensive Care Medicine vol. 47 , ( 1 ) 49 - 59 .

Amezcua-Prieto C, Ross J, Rogozińska E, Mighiu P, Martínez-Ruiz V, Brohi K, Bueno-Cavanillas A, Khan KS et al. ( 2020 ) . Maternal trauma due to motor vehicle crashes and pregnancy outcomes: a systematic review and meta-analysis . BMJ Open vol. 10 , ( 10 )

Guerreiro ML, Brohi K ( 2020 ) . Fibrino(Geno)Lysis: The New Kid in Town for Trauma Care . Journal of the American College of Surgeons . vol. 231 , s317 - s318 .

( 2020 ) . FEATURED ARTICLES FOR CME CREDIT SEPTEMBER 2020 . Journal of Trauma and Acute Care Surgery vol. 89 , ( 3 ) e89 - e91 .

Braasch MC, Turco LM, Cole EM, Brohi K, Winfield RD ( 2020 ) . The evolution of initial-hemostatic resuscitation and the void of posthemostatic resuscitation . J Trauma Acute Care Surg vol. 89 , ( 3 ) 597 - 601 .

Vulliamy P, Montague SJ, Gillespie S, Chan MV, Coupland LA, Andrews RK, Warner TD, Gardiner EE et al. ( 2020 ) . Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients . Blood Advances vol. 4 , ( 12 ) 2623 - 2630 .

Gall LS, Vulliamy P, Brohi K, Davenport RA ( 2020 ) . Response to the Comment on "The S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients" . Annals of Surgery vol. 271 , ( 4 ) e111 - e112 .

Moore HB, Gando S, Iba T, Kim PY, Yeh CH, Brohi K, Hunt BJ, Levy JH et al. ( 2020 ) . Defining trauma‐induced coagulopathy with respect to future implications for patient management: Communication from the SSC of the ISTH . Journal of Thrombosis and Haemostasis vol. 18 , ( 3 ) 740 - 747 .

Vulliamy P, Kornblith LZ, Kutcher ME, Cohen MJ, Brohi K, Neal MD ( 2020 ) . Alterations in platelet behavior after major trauma: adaptive or maladaptive? . Platelets vol. 32 , ( 3 ) 295 - 304 .

Perkins ZB, Yet B, Marsden M, Glasgow S, Marsh W, Davenport R, Brohi K, Tai NRM ( 2020 ) . Early Identification of Trauma-induced Coagulopathy . Annals of Surgery vol. 274 , ( 6 ) e1119 - e1128 .

Tucker H, Brohi K, Cardigan R, Davenport R, Davies J, Edmondson D, English W, Green L et al. ( 2020 ) . A national survey and simulation study of pre-hospital whole blood transfusion: what are the benefits? . BRITISH JOURNAL OF HAEMATOLOGY . vol. 189 , 164 - 165 .

Sohrabi C, Gillespie S, Rossetto A, Brohi K, Vulliamy P ( 2020 ) . Circulating levels of platelet factor 4 are elevated in the acute phase after severe traumatic brain injury . BRITISH JOURNAL OF SURGERY . vol. 107 , 128 - 128 .

Praditsuktavorn B, Wall J, Thiemermann C, Tremoleda JL, Brohi K ( 2020 ) . Rescuing Cardiac Dysfunction Following Traumatic Haemorrhagic Injury . CIRCULATION . vol. 142 , E496 - E497 .

Lopez Tremoleda J, Wall J, Naganathar V, Praditsuktavorn B, Bugg O, Mcarthur S, Thiemermann C, Brohi K ( 2019 ) . Modelling cardiac dysfunction following traumatic haemorrhage injury: impact on myocardial integrity . Frontiers in Immunology vol. 10 ,

Carden R, Lockey D, Brohi K ( 2019 ) . 034 Early cardiovascular dysfunction drives in-hospital trauma mortality . Emergency Medicine Journal vol. 36 , ( 12 )

COLE ELAINE, Gillespie S, Vulliamy P, Brohi K ( 2019 ) . Multiple organ dysfunction after trauma . British Journal of Surgery

Pearce AP, Marsden M, Newell N, Hancorn K, Lecky F, Brohi K, Tai N ( 2019 ) . Trends in admission timing and mechanism of injury can be used to improve general surgical trauma training . Annals of The Royal College of Surgeons of England vol. 102 , ( 1 ) 36 - 42 .

Cole E, Weaver A, Gall L, West A, Nevin D, Tallach R, O'Neill B, Lahiri S et al. ( 2019 ) . A Decade of Damage Control Resuscitation: New Transfusion Practice, New Survivors, New Directions . Ann Surg

Curry N, Brohi K ( 2019 ) . Surgery in Traumatic Injury and Perioperative Considerations . Seminars in Thrombosis and Hemostasis vol. 46 , ( 01 ) 073 - 082 .

Spyropoulos AC, Brohi K, Caprini J, Samama CM, Siegal D, Tafur A, Verhamme P, Douketis JD et al. ( 2019 ) . Scientific and Standardization Committee Communication: Guidance document on the periprocedural management of patients on chronic oral anticoagulant therapy: Recommendations for standardized reporting of procedural/surgical bleed risk and patient‐specific thromboembolic risk . Journal of Thrombosis and Haemostasis vol. 17 , ( 11 ) 1966 - 1972 .

Vulliamy P, Gillespie S, Armstrong P, Allan H, Warner T, Brohi K ( 2019 ) . Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage . Proceedings of the National Academy of Sciences

Sordi R, Chiazza F, Collotta D, Migliaretti G, Colas RA, Vulliamy P, Brohi K, Dalli J et al. ( 2019 ) . Resolvin D1 Attenuates the Organ Injury Associated With Experimental Hemorrhagic Shock . Ann Surg

Gall LS, Vulliamy P, Gillespie S, Jones TF, Pierre RSJ, Breukers SE, Gaarder C, Juffermans NP et al. ( 2019 ) . The S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients . Annals of Surgery vol. Publish Ahead of Pri , ( &NA; )

Gall LS, Vulliamy P, Gillespie S, Jones TF, Pierre RSJ, Breukers SE, Gaarder C, Juffermans NP et al. ( 2019 ) . The S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients . Ann Surg vol. 269 , ( 6 ) 1184 - 1191 .

Schyma BM, Cole E, Wren SM, Brohi K, Brundage SI ( 2019 ) . Delivering trauma mastery with an international trauma masters . Injury vol. 50 , ( 4 ) 877 - 882 .

Rehn M, Weaver A, Brohi K, Eshelby S, Green L, Røislien J, Lockey DJ ( 2019 ) . Effect of Prehospital Red Blood Cell Transfusion on Mortality and Time of Death in Civilian Trauma Patients . Shock vol. 51 , ( 3 ) 284 - 288 .

Juffermans NP, Wirtz MR, Balvers K, Baksaas‐Aasen K, van Dieren S, Gaarder C, Naess PA, Stanworth S et al. ( 2019 ) . Towards patient‐specific management of trauma hemorrhage: the effect of resuscitation therapy on parameters of thromboelastometry . Journal of Thrombosis and Haemostasis vol. 17 , ( 3 ) 441 - 448 .

Brohi K, Gruen RL, Holcomb JB ( 2019 ) . Why are bleeding trauma patients still dying? . Intensive Care Medicine vol. 45 , ( 5 ) 709 - 711 .

Thomas H, Foley C, Lucas J, Evans A, Davenport R, Curry N, Stanworth S, Brohi K ( 2019 ) . The challenges of delivering a time-critical intervention in emergency care . TRIALS . vol. 20 ,

Marsden M, Benger J, Brohi K, Curry N, Foley C, Green L, Lucas J, Rossetto A et al. ( 2018 ) . Coagulopathy, cryoprecipitate and CRYOSTAT-2: realising the potential of a nationwide trauma system for a national clinical trial . British Journal of Anaesthesia vol. 122 , ( 2 ) 164 - 169 .

Vulliamy P, Faulkner M, Kirkwood G, West A, O’Neill B, Griffiths MP, Moore F, Brohi K ( 2018 ) . Temporal and geographic patterns of stab injuries in young people: a retrospective cohort study from a UK major trauma centre . BMJ Open vol. 8 , ( 10 )

Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al. ( 2018 ) . Correction: Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study . PLoS Med vol. 15 , ( 10 ) e1002694 - e1002694 .

Crewdson K, Rehn M, Brohi K, Lockey DJ ( 2018 ) . Response letter to Voelckel et al . Acta Anaesthesiologica Scandinavica vol. 63 , ( 1 ) 140 - 140 .

Crewdson K, Rehn M, Brohi K, Lockey DJ ( 2018 ) . Response to Burns et al . Acta Anaesthesiologica Scandinavica vol. 63 , ( 1 ) 138 - 138 .

Glasgow SM, Perkins ZB, Tai NRM, Brohi K, Vasilakis C ( 2018 ) . Development of a discrete event simulation model for evaluating strategies of red blood cell provision following mass casualty events . European Journal of Operational Research vol. 270 , ( 1 ) 362 - 374 .

Jones TF, Torrance HDT, Owen HC, Brohi K, Barnes MR, Knight JC, Hinds CJ, Ackland GL et al. ( 2018 ) . MicroRNA profiles are associated with lymphocyte count after a major traumatic injury: a potential role for immunometabolism? . British Journal of Anaesthesia vol. 121 , ( 2 ) e23 - e24 .

Virdee J, Pafitanis G, Alamouti R, Brohi K, Patel H ( 2018 ) . Mind the gap: 11 years of train-related injuries at the Royal London Hospital Major Trauma Centre . Annals of The Royal College of Surgeons of England vol. 100 , ( 7 ) 520 - 528 .

MARSDEN M, CARDEN R, Navaratne L, Smith IM, Penn-Barwell JG, Kraven LM, BROHI KH, TAI N et al. ( 2018 ) . Outcomes following trauma laparotomy for hypotensive trauma patients: a UK military and civilian perspective . Journal of Trauma and Acute Care Surgery

Baksaas-Aasen K, Van Dieren S, Balvers K, Juffermans NP, Næss PA, Rourke C, Eaglestone S, Ostrowski SR et al. ( 2018 ) . Data-driven Development of ROTEM and TEG Algorithms for the Management of Trauma Hemorrhage: A Prospective Observational Multicenter Study . Ann Surg

Aswani A, Manson J, Itagaki K, Chiazza F, Collino M, Wupeng WL, Chan TK, Wong WSF et al. ( 2018 ) . Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage . Frontiers in Immunology vol. 9 ,

PROWLE JR ( 2018 ) . Acute Kidney Injury in Trauma Patients Admitted to Critical Care: Development and Validation of a Diagnostic Prediction Model . Scientific Reports

Harris T, Davenport R, Mak M, Brohi K ( 2018 ) . The Evolving Science of Trauma Resuscitation . Emerg Med Clin North Am vol. 36 , ( 1 ) 85 - 106 .

Crewdson K, Rehn M, Brohi K, Lockey DJ ( 2018 ) . Pre‐hospital emergency anaesthesia in awake hypotensive trauma patients: beneficial or detrimental? . Acta Anaesthesiologica Scandinavica vol. 62 , ( 4 ) 504 - 514 .

Brohi K ( 2018 ) . Shock and blood transfusion . Edition ,

Curry N, Rourke C, Davenport R, Beer S, Pankhurst L, Deary A, Thomas H, Llewelyn C et al. ( 2017 ) . Early cryoprecipitate for major haemorrhage in trauma: A randomised controlled feasibility trial . British Journal of Anaesthesia vol. 115 , ( 1 ) 76 - 83 .

VULLIAMY P, GILLESPIE S, ARMSTRONG P, CHAN M, DAVENPORT R, WARNER T, BROHI K ( 2017 ) . Platelets Shift Towards a Procoagulant and Proin ammatory Phenotype at the Expense of Aggregation During Trauma Hemorrhage: a Potential Role of Extracellular Histones . Circulation . Conference: American Heart Association Scientific Sessions ( Anaheim, CA ) from: 11/11/2017 to: 15/11/2017 , vol. e448-467 ,

Tremoleda JL, Watts SA, Reynolds PS, Thiemermann C, Brohi K ( 2017 ) . Modeling Acute Traumatic Hemorrhagic Shock Injury . Shock vol. 48 , ( 6 ) 610 - 623 .

Brohi K, Eaglestone S ( 2017 ) . Traumatic coagulopathy and massive transfusion: improving outcomes and saving blood . Programme Grants for Applied Research vol. 5 , ( 19 ) 1 - 74 .

Moran CG, Webb C, Brohi K, Smith M, Willett K ( 2017 ) . Lessons in planning from mass casualty events in UK . The BMJ vol. 359 ,

Baksaas-Aasen K, Gall L, Eaglestone S, Rourke C, Juffermans NP, Goslings JC, Naess PA, van Dieren S et al. ( 2017 ) . iTACTIC - implementing Treatment Algorithms for the Correction of Trauma-Induced Coagulopathy: study protocol for a multicentre, randomised controlled trial . Trials vol. 18 , ( 1 ) 486 - 486 .

Wilson NM, Wall J, Naganathar V, Brohi K, De'Ath HD ( 2017 ) . Mechanisms Involved in Secondary Cardiac Dysfunction in Animal Models of Trauma and Haemorrhagic Shock . Shock vol. 48 , ( 4 )

Wilson NM, Wall J, Naganathar V, Brohi K, De'Ath HD ( 2017 ) . Mechanisms Involved in Secondary Cardiac Dysfunction in Animal Models of Trauma and Hemorrhagic Shock . Shock vol. 48 , ( 4 ) 401 - 410 .

Nevin DG, Brohi K ( 2017 ) . Permissive hypotension for active haemorrhage in trauma . Anaesthesia vol. 72 , ( 12 ) 1443 - 1448 .

Brohi K, Davenport RA ( 2017 ) . In Reply . Anesthesiology vol. 127 , ( 3 ) 585 - 586 .

VULLIAMY P, GILLESPIE S, GALL L, GREEN L, Brohi K, Davenport R ( 2017 ) . Platelet transfusions reduce fibrinolysis but do not restore platelet function during trauma hemorrhage . Journal of Trauma and Acute Care Surgery vol. 83 , ( 3 ) 388 - 397 .

Asehnoune K, Balogh Z, Citerio G, Cap A, Billiar T, Stocchetti N, Cohen MJ, Pelosi P et al. ( 2017 ) . The research agenda for trauma critical care . Intensive Care Medicine vol. 43 , ( 9 ) 1340 - 1351 .

Brohi K, Schreiber M ( 2017 ) . The new survivors and a new era for trauma research . PLOS Medicine vol. 14 , ( 7 )

CABRERA CP, MANSON J, SHEPHERD JM, TORRANCE HD, WATSON D, LONGHI MP, HOTI M, PATEL MB et al. ( 2017 ) . Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma . PLoS Medicine

Sordi R, Nandra KK, Chiazza F, Johnson FL, Cabrera CP, Torrance HD, Yamada N, Patel NSA et al. ( 2017 ) . Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation . Ann Surg vol. 265 , ( 2 ) 408 - 417 .

Heath H, Renney G, Ward M, Cutillas P, Kudu H, Goldin R, Hutchins R, Foster G et al. ( 2017 ) . OC-080 Stat2 is a key mediator of acute pancreatitis . Gut . vol. 66 ,

Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al. ( 2017 ) . Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study . PLoS Med vol. 14 , ( 7 )

Lockey DJ, Brohi K ( 2017 ) . Pre-hospital thoracotomy and the evolution of pre-hospital critical care for victims of trauma . Injury vol. 48 , ( 9 ) 1863 - 1864 .

Balendran CA, Lövgren A, Hansson KM, Nelander K, Olsson M, Johansson KJ, Brohi K, Fries D et al. ( 2017 ) . Prothrombin time is predictive of low plasma prothrombin concentration and clinical outcome in patients with trauma hemorrhage: analyses of prospective observational cohort studies . Scand J Trauma Resusc Emerg Med vol. 25 , ( 1 ) 30 - 30 .

Yamada N, Lukas M, Zechendorf E, Purvis G, Chiazzo F, Varone B, Collino M, Shepherd J et al. ( 2017 ) . Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock . Annals of Surgery

GALL L, BROHI K, DAVENPORT R ( 2017 ) . Diagnosis And Treatment Of Hyperfibrinolysis In Trauma (A European Perspective) . Seminars in Thrombosis and Hemostasis

Balvers K, van Dieren S, Baksaas-Aasen K, Gaarder C, Brohi K, Eaglestone S, Stanworth S, Johansson PI et al. ( 2017 ) . Combined effect of therapeutic strategies for bleeding injury on early survival, transfusion needs and correction of coagulopathy . British Journal of Surgery vol. 104 , ( 3 ) 222 - 229 .

Yamada N, Martin L, Zechendorf E, Chiazza F, Varrone B, Collino M, Shepherd J, Heinbockel L et al. ( 2017 ) . A NOVEL SYNTHETIC, HOST-DEFENCE PEPTIDE PROTECTS AGAINST ORGAN INJURY/DYSFUNCTION IN A RAT-MODEL OF SEVERE HEMORRHAGIC SHOCK . vol. 47 , is. 6 , pp. 116 - 117 .

Davenport RA, Guerreiro M, Frith D, Rourke C, Platton S, Cohen M, Pearse R, Thiemermann C et al. ( 2017 ) . Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy . Anesthesiology vol. 126 , ( 1 ) 115 - 127 .

Rourke C, Davenport R, Brohi K ( 2017 ) . Informed consent in acute trauma resuscitation: experiences of a major trauma centre . TRIALS . vol. 18 ,

Vulliamy P, Gillespie S, Armstrong PC, Chan MV, Davenport RA, Warner TD, Brohi K ( 2017 ) . Platelets Shift Towards a Procoagulant and Proinflammatory Phenotype at the Expense of Aggregation During Trauma Hemorrhage: a Potential Role of Extracellular Histones . CIRCULATION . vol. 136 , E464 - E464 .

Perkins ZB, Lendrum RA, Brohi K ( 2016 ) . Resuscitative endovascular balloon occlusion of the aorta . vol. 22 , is. 6 , pp. 563 - 571 . Wolters Kluwer

Perkins ZB, Lendrum RA, Brohi K ( 2016 ) . Resuscitative endovascular balloon occlusion of the aorta: promise, practice, and progress? . Curr Opin Crit Care vol. 22 , ( 6 ) 563 - 571 .

Shepherd JM, Cole E, Brohi K ( 2016 ) . Contemporary patterns of multiple organ dysfunction in trauma . Shock

De'Ath HD, Oakland K, Brohi K ( 2016 ) . CT screened arterial calcification as a risk factor for mortality after trauma . Scand J Trauma Resusc Emerg Med vol. 24 , ( 1 ) 120 - 120 .

Bos L, Schouten L, van Vught L, Wiewel M, Ong D, Cremer O, Artigas A, Martin-Loeches I et al. ( 2016 ) . ESICM LIVES 2016: part one . Intensive Care Medicine Experimental vol. 4 , ( Suppl 1 )

Sivakumar S, Taccone FS, Desai KA, Lazaridis C, Skarzynski M, Sekhon M, Henderson W, Griesdale D et al. ( 2016 ) . ESICM LIVES 2016: part two : Milan, Italy. 1-5 October 2016 . Intensive Care Med Exp . Conference: ESICM Lives 2016 ( Germany ) vol. 4 , 30 - 30 .

Sharples A, Brohi K ( 2016 ) . Can clinical prediction tools predict the need for computed tomography in blunt abdominal? A systematic review . Injury vol. 47 , ( 8 ) 1811 - 1818 .

Glasgow S, Vasilakis C, Perkins Z, Brundage S, Tai N, Brohi K ( 2016 ) . Managing the surge in demand for blood following mass casualty events . Journal of Trauma and Acute Care Surgery vol. 81 , ( 1 ) 50 - 57 .

Cole E, Lecky F, West A, Smith N, Brohi K, Davenport R ( 2016 ) . The Impact of a Pan-regional Inclusive Trauma System on Quality of Care . Annals of Surgery vol. 264 , ( 1 ) 188 - 194 .

Glen J, Constanti M, Brohi K ( 2016 ) . Assessment and initial management of major trauma: summary of NICE guidance . The BMJ vol. 353 ,

Roberts DJ, Zygun DA, Faris PD, Ball CG, Kirkpatrick AW, Stelfox HT, Group IFTDCSIS, Brohi K et al. ( 2016 ) . Opinions of Practicing Surgeons on the Appropriateness of Published Indications for Use of Damage Control Surgery in Trauma Patients: An International Cross-Sectional Survey . Journal of the American College of Surgeons . vol. 223 , 515 - 529 .

Manson J, Cole E, De’Ath HD, Vulliamy P, Meier U, Pennington D, Brohi K ( 2016 ) . Early changes within the lymphocyte population are associated with the development of multiple organ dysfunction syndrome in trauma patients . Critical Care vol. 20 , ( 1 )

Hoffman KP, Playford DE, Grill E, Soberg HL, Brohi K ( 2016 ) . Minimum data set to measure rehabilitation needs and health outcome after major trauma: application of an international framework . Eur J Phys Rehabil Med vol. 52 , ( 3 ) 331 - 346 .

Heim C, Cole E, West A, Tai N, Brohi K ( 2016 ) . Survival prediction algorithms miss significant opportunities for improvement if used for case selection in trauma quality improvement programs . Injury

Roberts DJ, Bobrovitz N, Zygun DA, Ball CG, Kirkpatrick AW, Faris PD, Brohi K, D’Amours S et al. ( 2016 ) . Indications for Use of Damage Control Surgery in Civilian Trauma Patients . Annals of Surgery vol. 263 , ( 5 ) 1018 - 1027 .

Klein AA, Arnold P, Bingham RM, Brohi K, Clark R, Collis R, Gill R, McSporran W et al. ( 2016 ) . AAGBI guidelines: the use of blood components and their alternatives 2016 . Anaesthesia

Davenport RA, Brohi K ( 2016 ) . Cause of trauma-induced coagulopathy . Current Opinion in Anaesthesiology vol. 29 , ( 2 ) 212 - 219 .

Heim C, Steurer MP, Brohi K ( 2016 ) . Damage Control Resuscitation: More Than Just Transfusion Strategies . Current Anesthesiology Reports vol. 6 , ( 1 ) 72 - 78 .

Sordi R, Nandra KK, Chiazza F, Johnson FL, Cabrera CP, Torrance HD, Yamada N, Patel NSA et al. ( 2016 ) . Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation . Annals of surgery

Stanworth SJ, Davenport R, Curry N, Seeney F, Eaglestone S, Edwards A, Martin K, Allard S et al. ( 2016 ) . Mortality from trauma haemorrhage and opportunities for improvement in transfusion practice . British Journal of Surgery vol. 103 , ( 4 ) 357 - 365 .

( 2016 ) . A new device for the prevention of pulmonary embolism in critically ill patients . Journal of Trauma and Acute Care Surgery vol. 80 , ( 2 )

Sordi R, Nandra KK, Chiazza F, Johnson FL, Cabrera CP, Torrance HD, Yamada N, Patel NSA et al. ( 2016 ) . Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation . Ann Surg

Gall L, Davenport R, Brohi K ( 2016 ) . Effect of early tranexamic acid on the coagulation system in patients with suspected traumatic haemorrhage: a prospective cohort study . The Lancet . vol. 387 ,

Jenkins DH, Tai NRM, Brohi K ( 2016 ) . 3 Systems of Care in the Management of Vascular Injury . Rich's Vascular Trauma , Elsevier

Hagemo JS, Christiaans SC, Stanworth SJ, Brohi K, Johansson PI, Goslings JC, Naess PA, Gaarder C ( 2015 ) . Detection of acute traumatic coagulopathy and massive transfusion requirements by means of rotational thromboelastometry: an international prospective validation study . Critical Care vol. 19 , ( 1 )

Campbell HE, Stokes EA, Bargo DN, Curry N, Lecky FE, Edwards A, Woodford M, Seeney F et al. ( 2015 ) . Quantifying the healthcare costs of treating severely bleeding major trauma patients: a national study for England . Critical Care vol. 19 , ( 1 )

Brohi K ( 2015 ) . The trials of being a national trauma registry . Emergency Medicine Journal vol. 32 , ( 12 )

Owen HC, Torrance HDT, Jones TF, Pearse RM, Hinds CJ, Brohi K, O’Dwyer MJ ( 2015 ) . Epigenetic regulatory pathways involving microRNAs may modulate the host immune response following major trauma . Journal of Trauma and Acute Care Surgery vol. 79 , ( 5 ) 766 - 772 .

Vulliamy PE, Perkins ZB, Brohi K, Manson J ( 2015 ) . Persistent lymphopenia is an independent predictor of mortality in critically ill emergency general surgical patients . European Journal of Trauma and Emergency Surgery vol. 42 , ( 6 ) 755 - 760 .

Schäfer N, Driessen A, Fröhlich M, Stürmer EK, Maegele M, TACTIC partners ( 2015 ) . Diversity in clinical management and protocols for the treatment of major bleeding trauma patients across European level I Trauma Centres . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine vol. 23 , ( 1 )

Roberts DJ, Bobrovitz N, Zygun DA, Ball CG, Kirkpatrick AW, Faris PD, Parry N, Nicol AJ et al. ( 2015 ) . Indications for use of thoracic, abdominal, pelvic, and vascular damage control interventions in trauma patients . Journal of Trauma and Acute Care Surgery vol. 79 , ( 4 ) 568 - 579 .

Shepherd JM, Cole E, Brohi K ( 2015 ) . T-5: PATTERNS OF MULTI-ORGAN DYSFUNCTION IN SEVERELY INJURED PATIENTS WITH HAEMORRHAGE . Shock . vol. 44 Suppl 2 ,

Torrance H, Brohi K, Warnes G, Owen H, Hinds C, Pennington D, O'Dwyer M ( 2015 ) . T-helper cell polarisation following severe polytrauma . Intensive Care Medicine Experimental vol. 3 , ( Suppl 1 )

Owen H, Torrance H, Barnes M, Brohi K, Knight J, Hinds C, O'Dwyer M ( 2015 ) . The Role of Micrornas in The Development of Hospital Acquired Infection in Polytrauma Patients . Intensive Care Medicine Experimental vol. 3 , ( Suppl 1 )

Jones TF, Owen HC, Torrance HD, Pirmadjid N, Brohi K, Hinds CJ, O'Dwyer MJ ( 2015 ) . MicroRNA-mediated regulation of IL-10, IL-12 and TNFα gene expression in severely injured trauma patients . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine . vol. 23 ,

Taccone FS, Bunker N, Waldmann C, De Backer D, Brohi K, Jones RG, Vincent J-L ( 2015 ) . A new device for the prevention of pulmonary embolism in critically ill patients . Journal of Trauma and Acute Care Surgery vol. 79 , ( 3 ) 456 - 462 .

Watts S, Nordmann G, Brohi K, Midwinter M, Woolley T, Gwyther R, Wilson C, Poon H et al. ( 2015 ) . Evaluation of Prehospital Blood Products to Attenuate Acute Coagulopathy of Trauma in a Model of Severe Injury and Shock in Anesthetized Pigs . Shock vol. 44 , ( &NA; ) 138 - 148 .

Naganathar S, De''Ath HD, Wall J, BROHI K ( 2015 ) . Admission biomarkers of trauma-induced secondary cardiac injury predict adverse cardiac events and are associated with plasma catecholamine levels . Journal of Trauma and Acute Care Surgery vol. 79 , ( 1 ) 71 - 77 .

Sordi R, Chiazza F, Johnson FL, Patel NSA, Brohi K, Collino M, Thiemermann C ( 2015 ) . Inhibition of IκB Kinase Attenuates the Organ Injury and Dysfunction Associated with Hemorrhagic Shock . Molecular Medicine vol. 21 , ( 1 ) 563 - 575 .

Colom B, Bodkin JV, Beyrau M, Woodfin A, Ody C, Rourke C, Chavakis T, Brohi K et al. ( 2015 ) . Leukotriene B<inf>4</inf>-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration InVivo . Immunity vol. 42 , ( 6 ) 1075 - 1086 .

Colom B, Bodkin JV, Beyrau M, Woodfin A, Ody C, Rourke C, Chavakis T, Brohi K et al. ( 2015 ) . Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo . Immunity vol. 42 , ( 6 ) 1075 - 1086 .

Davenport R, Khan S, Brohi K ( 2015 ) . Re . Journal of Trauma and Acute Care Surgery vol. 78 , ( 6 ) 1237 - 1238 .

Hoffman K, Silvester L, Nott P, Goodfellow T, Richardson D, Wolstenholme S, Turnbull J, Jenks T et al. ( 2015 ) . Evaluation of the value of rehabilitation prescriptions within four major trauma hospitals . Physiotherapy vol. 101 ,

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O'Dwyer MJ ( 2015 ) . Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients . Annals of Surgery vol. 261 , ( 4 ) 751 - 759 .

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, OʼDwyer MJ ( 2015 ) . Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients . Ann Surg vol. 261 , ( 4 ) 751 - 759 .

Perkins ZB, Yet B, Glasgow S, Cole E, Marsh W, Brohi K, Rasmussen TE, Tai NRM ( 2015 ) . Meta-analysis of prognostic factors for amputation following surgical repair of lower extremity vascular trauma . British Journal of Surgery vol. 102 , ( 5 ) 436 - 450 .

Balvers K, Wirtz M, Rourke C, Eaglestone S, Brohi K, Stanworth S, Gaarder C, Goslings J et al. ( 2015 ) . Effect of the haemoglobin level on neurologic outcome in patients with severe traumatic brain injury . Critical Care vol. 19 , ( Suppl 1 )

Brohi K ( 2015 ) . Make the bleeding stop . Science Translational Medicine vol. 7 , ( 277 )

Perkins ZB, Yet B, Glasgow S, Cole E, Marsh W, Brohi K, Rasmussen TE, Tai NRM ( 2015 ) . Meta‐analysis of prognostic factors for amputation following surgical repair of lower extremity vascular trauma . British Journal of Surgery vol. 102 , ( 5 ) 436 - 450 .

Cole E, Davenport R, Willett K, Brohi K ( 2015 ) . Tranexamic acid use in severely injured civilian patients and the effects on outcomes: a prospective cohort study . Ann Surg vol. 261 , ( 2 ) 390 - 394 .

Torrance HD, Vivian ME, Brohi K, Prowle JR, Pearse RM, Owen HC, Hinds CJ, O'Dwyer MJ ( 2015 ) . Changes in gene expression following trauma are related to the age of transfused packed red blood cells . J Trauma Acute Care Surg vol. 78 , ( 3 ) 535 - 542 .

Glasgow S, Vasilakis C, Perkins Z, Tai N, Brohi K ( 2015 ) . DEVELOPING TRANSFUSION BASED STRATEGIES FOR OPTIMISING OUTCOMES FOLLOWING MASS CASUALTY EVENTS USING A DISCRETE EVENT SIMULATION MODELLING APPROACH . SHOCK . vol. 44 , 5 - 6 .

Wall JM, Tremoleda JL, Thiemermann C, Brohi K ( 2015 ) . HEART FATTY ACID BINDING PROTEIN (H-FABP) IS A BIOMARKER OF TRAUMA-INDUCED SECONDARY CARDIAC INJURY IN A PRE-CLINICAL MODEL OF TRAUMA-HAEMORRHAGE . SHOCK . vol. 44 , 21 - 22 .

Taccone FS, Bunker N, Waldmann C, De Backer D, Brohi K, Jones RG, Vincent J-L ( 2015 ) . Nonopioid management of acute pain associated with trauma: Focus on pharmacologic options . JOURNAL OF TRAUMA AND ACUTE CARE SURGERY vol. 79 , ( 3 ) 456 - 462 .

Shepherd JM, Cole E, Brohi K ( 2015 ) . PATTERNS OF MULTI-ORGAN DYSFUNCTION IN SEVERELY INJURED PATIENTS WITH HAEMORRHAGE . SHOCK . vol. 44 , 21 - 21 .

Whitaker J, West A, Brohi K, Sivapathasuntharam D ( 2015 ) . Reason for Admission and Outcomes for Older Patients Admitted to a Major Trauma Centre . BRITISH JOURNAL OF SURGERY . vol. 102 , 86 - 86 .

Vulliamy PE, Perkins ZB, Brohi K, Manson J ( 2015 ) . SEVERE LYMPHOPENIA IN EMERGENCY SURGICAL PATIENTS IS ASSOCIATED WITH ILLNESS SEVERITY AND MORTALITY . SHOCK . vol. 44 , 10 - 11 .

Jenkins DH, Tai NRM, Brohi K ( 2015 ) . Systems of Care in the Management of Vascular Injury . Rich's Vascular Trauma ,

Frith D, Wall J, Baptista M, Brohi K ( 2015 ) . THROMBIN GENERATION POTENTIAL DECLINES DURING TRAUMA HAEMORRHAGE DESPITE HAEMOSTATIC RESUSCITATION . SHOCK . vol. 44 , 1 - 2 .

Gall L, Davenport R, Brohi K ( 2015 ) . TRANEXAMIC ACID IS ASSOCIATED WITH ENHANCED CLOT STRENGTH, REDUCED FIBRINOLYSIS AND REDUCED ACUTE TRAUMATIC COAGULOPATHY IN BLEEDING TRAUMA PATIENTS . SHOCK . vol. 44 , 4 - 4 .

Sordi R, Nandra KK, Chiazza F, Patel NSA, Brohi K, Collino M, Thiemermann C ( 2015 ) . TRAUMA ORGAN PROTECTION WITH ARTESUNATE (TOP-ART): PRECLINICAL EFFICACY OF AN ANTIMALARIAL DRUG WITH EXCELLENT SAFETY PROFILE AND PLANNED PHASE II RCT . SHOCK . vol. 44 , 1 - 1 .

Jones TF, Gillespie S, Gall LS, Davenport RA, Brohi K ( 2015 ) . VENOUS THROMBOEMBOLIC EVENTS AFTER TRAUMATIC INJURY ARE ASSOCIATED WITH EARLY CHANGES TO THE FIBRINOLYTIC SYSTEM . SHOCK . vol. 44 , 24 - 24 .

Müller MC, Balvers K, Binnekade JM, Curry N, Stanworth S, Gaarder C, Kolstadbraaten KM, Rourke C et al. ( 2014 ) . Thromboelastometry and organ failure in trauma patients: a prospective cohort study . Critical Care vol. 18 , ( 6 )

Khan S, Davenport R, Raza I, Glasgow S, De’Ath HD, Johansson PI, Curry N, Stanworth S et al. ( 2014 ) . Damage control resuscitation using blood component therapy in standard doses has a limited effect on coagulopathy during trauma hemorrhage . Intensive Care Medicine vol. 41 , ( 2 ) 239 - 247 .

Chou D, Barry M, Brohi K ( 2014 ) . Principles of resuscitation and polytrauma management . Orthopaedic Trauma , Taylor & Francis

Bird R, Lawless J, Davenport R, Rourke C, Weaver A, Brohi K, Nevin D ( 2014 ) . Rotational thromboelastometry (ROTEM) – The future of haemostatic resuscitation in major trauma centres . International Journal of Surgery vol. 12 ,

Lord JM, Midwinter MJ, Chen YF, Belli A, Brohi K, Kovacs EJ, Koenderman L, Kubes P et al. ( 2014 ) . The systemic immune response to trauma: An overview of pathophysiology and treatment . The Lancet vol. 384 , ( 9952 ) 1455 - 1465 .

Asehnoune K, Faraoni D, Brohi K ( 2014 ) . What’s new in management of traumatic coagulopathy? . Intensive Care Medicine vol. 40 , ( 11 ) 1727 - 1730 .

Owen H, Torrance H, Brohi K, Hinds C, O'Dwyer M ( 2014 ) . 1068. MicroRNA-regulated immunosuppression in severely injured polytrauma patients . Intensive Care Medicine Experimental vol. 2 , ( Suppl 1 )

Frith D, Brohi K ( 2014 ) . Massive Transfusion in Trauma . Transfusion in the Intensive Care Unit , Springer Nature

Sivapathasuntharam D, Whitaker J, West A, Brohi K ( 2014 ) . P532: Reason for admission and outcomes for older patients presenting to a major trauma centre . European Geriatric Medicine vol. 5 ,

Perkins ZB, Maytham GD, Koers L, Bates P, Brohi K, Tai NRM ( 2014 ) . Impact on outcome of a targeted performance improvement programme in haemodynamically unstable patients with a pelvic fracture . Bone Joint J vol. 96-B , ( 8 ) 1090 - 1097 .

Heim C, Brohi K ( 2014 ) . Perioperative Hemostasis in Trauma . Perioperative Hemostasis , Springer Nature

Asehnoune K, Faraoni D, Brohi K ( 2014 ) . What's new in management of traumatic coagulopathy? . Intensive Care Medicine

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O’Dwyer MJ ( 2014 ) . Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine . vol. 22 ,

Curry N, Rourke C, Davenport R, Stanworth S, Brohi K ( 2014 ) . Fibrinogen replacement in trauma haemorrhage . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine vol. 22 , ( Suppl 1 )

Guerreiro M, Tremoleda JL, Frith D, Thiemermann C, Brohi K ( 2014 ) . Reduction of the natural Activated protein C pathway activity significantly prevents coagulopathy in a murine model of acute traumatic coagulopathy . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine vol. 22 , ( Suppl 1 )

Jenkins DH, Rappold JF, Badloe JF, Berséus O, Blackbourne L, Brohi KH, Butler FK, Cap AP et al. ( 2014 ) . Trauma hemostasis and oxygenation research position paper on remote damage control resuscitation: definitions, current practice, and knowledge gaps . Shock vol. 41 Suppl 1 , ( 0 1 ) 3 - 12 .

Hagemo JS, Stanworth S, Juffermans NP, Brohi K, Cohen MJ, Johansson PI, Røislien J, Eken T et al. ( 2014 ) . Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: A multicentre observational study . Critical Care vol. 18 , ( 2 )

Khan S, Brohi K, Chana M, Raza I, Stanworth S, Gaarder C, Davenport R ( 2014 ) . Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage . Journal of Trauma and Acute Care Surgery vol. 76 , ( 3 ) 561 - 568 .

Cole E, Davenport R, Willett K, Brohi K ( 2014 ) . The burden of infection in severely injured trauma patients and the relationship with admission shock severity . Journal of Trauma and Acute Care Surgery vol. 76 , ( 3 ) 730 - 735 .

Cole E, Davenport R, Willett K, Brohi K ( 2014 ) . The burden of infection in severely injured trauma patients and the relationship with admission shock severity . J Trauma Acute Care Surg vol. 76 , ( 3 ) 730 - 735 .

Dua A, Frith D, Wade CE, Holcomb JB, Brohi K ( 2014 ) . The Effect of Aging on Acute Traumatic Coagulopathy . Journal of Surgical Research vol. 186 , ( 2 )

Hoffman K, Cole E, Playford ED, Grill E, Soberg HL, Brohi K ( 2014 ) . Health outcome after major trauma: what are we measuring? . PLoS One vol. 9 , ( 7 )

Khan S, Brohi K, Chana M, Raza I, Stanworth S, Gaarder C, Davenport R ( 2014 ) . Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage . Journal of Trauma and Acute Care Surgery vol. 76 , ( 3 ) 561 - 568 .

Perkins ZB, Maytham GD, Koers L, Bates P, Brohi K, Tai NRM ( 2014 ) . Impact on outcome of a targeted performance improvement programme in haemodynamically unstable patients with a pelvic fracture . Bone and Joint Journal vol. 96 B , ( 8 ) 1090 - 1097 .

Perkins ZB, Yet B, Glasgow S, Marsh W, Brohi K, Rasmussen TE, Tai NR ( 2014 ) . Prognostic Factors for Amputation Following Surgical Repair of Lower Extremity Vascular Trauma: A Systematic Review and Meta-Analysis of Observational Studies . JOURNAL OF VASCULAR SURGERY . vol. 59 , 75S - 75S .

Guerreiro ML, Tremoleda JL, Thiemermann C, Brohi K ( 2014 ) . REDUCTION OF NATURAL ACTIVATED PROTEIN C PREVENTS COAGULOPATHY IN A PRECLINICAL ANIMAL MODEL OF ACUTE TRAUMATIC COAGULOPATHY . SHOCK . vol. 41 , 51 - 51 .

Vivian M, Torrance HDT, Pearse R, Brohi K, Hinds CJ, O'Dwyer MJ ( 2014 ) . THE AGE OF TRANSFUSED PACKED RED BLOOD CELLS CORRELATES WITH THE DEGREE OF IMMUNOSUPPRESSION AS ASSESSED BY GENE EXPRESSION PATTERNS IN SEVERELY INJURED TRAUMA PATIENTS . INTENSIVE CARE MEDICINE . vol. 40 , S20 - S20 .

Davenport R, Brohi K ( 2013 ) . Fibrinogen depletion in trauma: early, easy to estimate and central to trauma-induced coagulopathy . Crit Care vol. 17 , ( 5 )

Glasgow S, Davenport R, Perkins Z, Tai N, Brohi K ( 2013 ) . A comprehensive review of blood product use in civilian mass casualty events . J Trauma Acute Care Surg vol. 75 , ( 3 ) 468 - 474 .

Brockamp T, Maegele M, Gaarder C, Goslings JC, Cohen MJ, Lefering R, Joosse P, Naess PA et al. ( 2013 ) . Comparison of the predictive performance of the BIG, TRISS, and PS09 score in anadult trauma population derived from multiple international trauma registries . Critical Care vol. 17 , ( 4 )

Hunt BJ, Raza I, Brohi K ( 2013 ) . The incidence and magnitude of fibrinolytic activation in trauma patients: A reply to a rebuttal . Journal of Thrombosis and Haemostasis vol. 11 , ( 7 ) 1437 - 1438 .

Perkins Z, Maytham G, Koers L, Bates P, Brohi K, Tai N ( 2013 ) . A targeted performance improvement programme reduces mortality in exsanguinating pelvic trauma . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine vol. 21 , ( Suppl 1 )

Frith D, Lima-Baptista M, Davenport R, Rourke C, Manson J, De-Ath H, Khan S, Raza I et al. ( 2013 ) . Thromboelastometry diagnosed Acute Traumatic Coagulopathy (ATC) identifies trauma patients with poor clinical outcomes better than Disseminated Intravascular Coagulation (DIC) scoring . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine vol. 21 , ( Suppl 1 )

Khan S, Allard S, Weaver A, Barber C, Davenport R, Brohi K ( 2013 ) . A major haemorrhage protocol improves the delivery of blood component therapy and reduces waste in trauma massive transfusion . Injury vol. 44 , ( 5 ) 587 - 592 .

Khan S, Allard S, Weaver A, Barber C, Davenport R, Brohi K ( 2013 ) . A major haemorrhage protocol improves the delivery of blood component therapy and reduces waste in trauma massive transfusion . Injury vol. 44 , ( 5 ) 587 - 592 .

Hagemo JS, Næss PA, Johansson P, Windeløv NA, Cohen MJ, Røislien J, Brohi K, Heier HE et al. ( 2013 ) . Evaluation of TEG^® and RoTEM^® inter-changeability in trauma patients . Injury vol. 44 , ( 5 ) 600 - 605 .

De'Ath HD, Manson J, Davenport R, Glasgow S, Renfrew I, Davies LC, Uppal R, Brohi K ( 2013 ) . Trauma-induced secondary cardiac injury is associated with hyperacute elevations in inflammatory cytokines . Shock vol. 39 , ( 5 ) 415 - 420 .

Abrams ST, Manson J, Liu T, Alhamdi Y, Brohi K, Wang G, Toh CH ( 2013 ) . Pro-thrombotic properties of circulating histones cause microcirculatory obstruction and acute respiratory failure . BRITISH JOURNAL OF HAEMATOLOGY vol. 161 , ( SI, Suplement 1 ) Article 000317864900012 , 6 - 6 .

Torrance H, Brohi K, Hinds C, O'Dwyer M ( 2013 ) . Cytokine gene expression can predict infectious complications following severe trauma . Critical Care vol. 17 , ( Suppl 2 )

Raza I, Davenport R, Rourke C, Platton S, Manson J, Spoors C, Khan S, De'Ath HD et al. ( 2013 ) . The incidence and magnitude of fibrinolytic activation in trauma patients . J Thromb Haemost vol. 11 , ( 2 ) 307 - 314 .

Abrams ST, Zhang N, Manson J, Liu T, Dart C, Baluwa F, Wang SS, Brohi K et al. ( 2013 ) . Circulating histones are mediators of trauma-associated lung injury . American Journal of Respiratory and Critical Care Medicine vol. 187 , ( 2 ) 160 - 169 .

Glasgow SM, Perkins ZB, Davenport R, Tai NRM, Brohi K ( 2013 ) . A 100 year review of blood use in civilian mass casualty events - how best to predict future needs . BRITISH JOURNAL OF SURGERY . vol. 100 , 31 - 31 .

Perkins ZB, Glasgow S, Brohi K, Tai NRM ( 2013 ) . A systematic review and meta-analysis of prognostic variables for secondary amputation following surgical repair of lower extremity vascular trauma . BRITISH JOURNAL OF SURGERY . vol. 100 , 51 - 51 .

Davenport R, Frith D, Geurreiro M, Rourke C, Khan S, Raza I, Platton S, Cohen M et al. ( 2013 ) . ACTIVATED PROTEIN C IS CENTRAL TO SYSTEMIC FIBRINOLYSIS BUT NOT ANTICOAGULATION IN ACUTE TRAUMATIC COAGULOPATHY . SHOCK . vol. 40 , 24 - 24 .

Raza I, Khan S, Rourke C, Davenport R, Platton S, Carvalho R, Arrowsmith D, Brohi K ( 2013 ) . ACUTE TRAUMATIC COAGULOPATHY HAS MULTIPLE IMPORTANT PATTERNS OF COAGULATION SYSTEM DERANGEMENT . SHOCK . vol. 40 , 34 - 34 .

Abrams ST, Manson J, Liu T, Baluwa F, Barrera V, Brohi K, Thachil J, Wang G et al. ( 2013 ) . Acute phase proteins reduce histone-induced platelet aggregation and coagulation activation . JOURNAL OF THROMBOSIS AND HAEMOSTASIS vol. 11 , 22 - 22 .

Torrance HDT, Brohi K, Pearse RM, Fragkou P, Hinds CJ, O'Dwyer MJ ( 2013 ) . BLOOD TRANSFUSION FOLLOWING SEVERE TRAUMA IS ASSOCIATED WITH THE DEVELOPMENT OF AN EARLY ANTI-INFLAMMATORY RESPONSE . INTENSIVE CARE MEDICINE . vol. 39 , S386 - S387 .

Cole EM, West A, Davenport R, Naganathar S, Kanzara T, Carey M, Brohi K ( 2013 ) . Can residents be effective trauma team leaders in a major trauma centre? . Injury vol. 44 , ( 1 ) 18 - 22 .

Abrams ST, Manson J, Liu T, Alhamdi Y, Brohi K, Wang G, Toh CH ( 2013 ) . Circulating histone-induced thrombosis leads to circulatory and respiratory failure . JOURNAL OF THROMBOSIS AND HAEMOSTASIS vol. 11 , 128 - 128 .

Cole E, Davenport R, De'Ath H, Manson J, Brockamp T, Brohi K ( 2013 ) . Coagulation system changes associated with susceptibility to infection in trauma patients . J Trauma Acute Care Surg vol. 74 , ( 1 ) 51 - 57 .

Perkins Z, Yet B, Glasgow S, Brohi K, Marsh W, Tai NRM ( 2013 ) . EARLY PREDICTION OF TRAUMATIC COAGULOPATHY USING ADMISSION CLINICAL VARIABLES . SHOCK . vol. 40 , 25 - 25 .

Abrams S, Manson J, Liu T, Alhamdi Y, Brohi K, Wang G, Toh C ( 2013 ) . EXTRACELLULAR HISTONES-INDUCE MICROCIRCULATORY THROMBOSIS AND ACUTE RESPIRATORY FAILURE . HAEMATOLOGICA . vol. 98 , 259 - 259 .

Khan S, Raza I, Davenport R, Glasgow S, Perkins Z, De'Ath H, Cole E, Stanworth S et al. ( 2013 ) . MAJOR HEMORRHAGE PROTOCOLS HAVE A LIMITED EFFECT ON TRAUMA-INDUCED COAGULOPATHY . SHOCK . vol. 40 , 34 - 34 .

Hoffman K, West A, Nott P, Cole E, Playford D, Liu C, Brohi K ( 2013 ) . Measuring acute rehabilitation needs in trauma: Preliminary evaluation of the Rehabilitation Complexity Scale . Injury vol. 44 , ( 1 ) 104 - 109 .

Hoffman K, West A, Nott P, Cole E, Playford D, Liu C, Brohi K ( 2013 ) . Measuring acute rehabilitation needs in trauma: preliminary evaluation of the Rehabilitation Complexity Scale . Injury vol. 44 , ( 1 ) 104 - 109 .

Willink M, Khan S, Cole E, Raza I, Glasgow S, Brohi K, Davenport R ( 2013 ) . OUTCOMES FOLLOWING TRAUMA HEMORRHAGE . SHOCK . vol. 40 , 28 - 29 .

Raza I, Khan S, Rourke C, Platton S, Davenport R, Brohi K ( 2013 ) . THE RELATIVE CONTRIBUTIONS OF PAI-1, TAFI, AND FACTOR XI IN ACUTE TRAUMATIC COAGULOPATHY . SHOCK . vol. 40 , 22 - 22 .

Cole E, Davenport R, Glasgow S, Khan S, Raza I, Rourke C, Perkins Z, Brohi K ( 2013 ) . TRANEXAMIC ACID USE IN SHOCKED SEVERELY INJURED PATIENTS AND THE EFFECTS ON OUTCOMES . SHOCK . vol. 40 , 21 - 21 .

Vulliamy P, Manson J, Brohi K ( 2013 ) . The admission differential white cell count in trauma - relationship with shock, injury severity and outcome . BRITISH JOURNAL OF SURGERY . vol. 100 , 30 - 30 .

Oakland K, De'Ath H, Brohi K ( 2013 ) . The incidence of calcified atherosclerosis and association with in-hospital mortality in trauma . BRITISH JOURNAL OF SURGERY . vol. 100 , 30 - 30 .

Frith D, Brohi K ( 2012 ) . The pathophysiology of trauma-induced coagulopathy . Curr Opin Crit Care vol. 18 , ( 6 ) 631 - 636 .

Gruen RL, Brohi K, Schreiber M, Balogh ZJ, Pitt V, Narayan M, Maier RV ( 2012 ) . Haemorrhage control in severely injured patients . Lancet vol. 380 , ( 9847 ) 1099 - 1108 .

Harris T, Thomas GOR, Brohi K ( 2012 ) . Early fluid resuscitation in severe trauma . BMJ vol. 345 ,

Adams A, Fotiadis N, Chin JY, Sapsford W, Brohi K ( 2012 ) . A pictorial review of traumatic pericardial injuries . Insights Imaging vol. 3 , ( 4 ) 307 - 311 .

Perkins ZB, De'Ath HD, Aylwin C, Brohi K, Walsh M, Tai NRM ( 2012 ) . Epidemiology and outcome of vascular trauma at a British Major Trauma Centre . Eur J Vasc Endovasc Surg vol. 44 , ( 2 ) 203 - 209 .

Rourke C, Curry N, Khan S, Taylor R, Raza I, Davenport R, Stanworth S, Brohi K ( 2012 ) . Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes . J Thromb Haemost vol. 10 , ( 7 ) 1342 - 1351 .

De'Ath HD, Rourke C, Davenport R, Manson J, Renfrew I, Uppal R, Davies LC, Brohi K ( 2012 ) . Clinical and biomarker profile of trauma-induced secondary cardiac injury . British Journal of Surgery vol. 99 , ( 6 ) 789 - 797 .

De'Ath HD, Rourke C, Davenport R, Manson J, Renfrew I, Uppal R, Davies LC, Brohi K ( 2012 ) . Clinical and biomarker profile of trauma-induced secondary cardiac injury . Br J Surg vol. 99 , ( 6 ) 789 - 797 .

Frith D, Cohen MJ, Brohi K ( 2012 ) . Animal models of trauma-induced coagulopathy . Thromb Res vol. 129 , ( 5 ) 551 - 556 .

Frith D, Davenport R, Brohi K ( 2012 ) . Acute traumatic coagulopathy . Curr Opin Anaesthesiol vol. 25 , ( 2 ) 229 - 234 .

Chana M, Manson J, Davenport R, De'Ath H, Spoors C, Raza I, Khan S, Coates A et al. ( 2012 ) . Time course of lactate clearance in trauma and its relevance to outcomes . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine vol. 20 , ( Suppl 1 )

Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, Pittet JF ( 2012 ) . Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients . Ann Surg vol. 255 , ( 2 ) 379 - 385 .

Fuller G, Bouamra O, Woodford M, Jenks T, Stanworth S, Allard S, Coats TJ, Brohi K et al. ( 2012 ) . Recent massive blood transfusion practice in England and Wales: view from a trauma registry . Emerg Med J vol. 29 , ( 2 ) 118 - 123 .

Brohi K ( 2012 ) . A strategy for future trauma research . Br J Surg vol. 99 Suppl 1 , 4 - 5 .

Khan S, Allard S, Weaver A, Barber C, Davenport R, Brohi K ( 2012 ) . A trauma major haemorrhage protocol reduces waste and improves the delivery of blood component therapy . BRITISH JOURNAL OF SURGERY . vol. 99 , 44 - 44 .

Harris T, Thomas GO, Brohi K ( 2012 ) . Authors' reply to Wiles and Chitnavis . BMJ vol. 345 ,

Frith D, Guerreiro M, Pearse R, Thiemermann C, Brohi K ( 2012 ) . EXPERIMENTAL ACUTE TRAUMATIC COAGULOPATHY IS ASSOCIATED WITH MODERATE IMPAIRMENT OF THROMBIN GENERATION AND DYSFIBRINOGENEMIA . SHOCK . vol. 37 , 34 - 34 .

Harris T, Thomas GOR, Brohi K ( 2012 ) . Early fluid resuscitation in severe trauma . BMJ: British Medical Journal vol. 345 , Article ARTN e7266 ,

Roberts I, Perel P, Prieto-Merino D, Shakur H, Coats T, Hunt BJ, Lecky F, Brohi K et al. ( 2012 ) . Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial . BMJ-BRITISH MEDICAL JOURNAL vol. 345 , Article ARTN e5839 ,

Hagemo JS, Næss PA, Johansson P, Windeløv NA, Cohen MJ, Røislien J, Brohi K, Heier HE et al. ( 2012 ) . Evaluation of TEG® and RoTEM® inter-changeability in trauma patients . Injury

Davenport R, Brohi K ( 2012 ) . HYPOPERFUSION & ACTIVATION OF PROTEIN C IN TRAUMA . SHOCK . vol. 38 , 1 - 1 .

Oakland K, De'Ath H, Brohi K ( 2012 ) . Mesenteric Vessel Calcification Predicts Mortality in Older Trauma Patients . BRITISH JOURNAL OF SURGERY . vol. 99 , 39 - 39 .

Manson J, Thiemermann C, Brohi K ( 2012 ) . Trauma alarmins as activators of damage-induced inflammation . Br J Surg vol. 99 Suppl 1 , 12 - 20 .

Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, Hart D, Pearse R et al. ( 2011 ) . Functional definition and characterization of acute traumatic coagulopathy . Crit Care Med vol. 39 , ( 12 ) 2652 - 2658 .

Brohi K, Cole E, Hoffman K ( 2011 ) . Improving outcomes in the early phases after major trauma . Curr Opin Crit Care vol. 17 , ( 5 ) 515 - 519 .

Brohi K ( 2011 ) . Prediction of acute traumatic coagulopathy and massive transfusion - Is this the best we can do? . Resuscitation vol. 82 , ( 9 ) 1128 - 1129 .

Davenport R, Rourke C, Manson J, De'Ath H, Platton S, Coates A, Hart D, Pearse P et al. ( 2011 ) . Activated protein C is a principle mediator of acute traumatic coagulopathy . J THROMB HAEMOST vol. 9 , 51 - 52 .

Rourke C, Curry NS, Khan S, Stanworth S, Brohi K ( 2011 ) . Characterization of fibrinogen depletion and response to replacement therapy in bleeding trauma patients . J THROMB HAEMOST vol. 9 , 121 - 121 .

Curry N, Stanworth S, Hopewell S, Doree C, Brohi K, Hyde C ( 2011 ) . Trauma-Induced Coagulopathy-A Review of the Systematic Reviews: Is There Sufficient Evidence to Guide Clinical Transfusion Practice? . TRANSFUS MED REV vol. 25 , ( 3 ) 217 - 231 .

Manson J, Davenport R, Coates A, Rourke C, De'Ath HD, Raza I, Spoors C, Khan S et al. ( 2011 ) . TRAUMATIC TISSUE DAMAGE: THE SEARCH FOR TRAUMA ALARMINS . INFLAMMATION RESEARCH . vol. 60 , 160 - 160 .

Manson J, Abrams S, Wang G, Toh C, Brohi K ( 2011 ) . Circulating nucleosomes suggest that cell death occurs during hypoperfusion after trauma . BRITISH JOURNAL OF SURGERY . vol. 98 , 16 - 16 .

De'Ath HDI, Rourke C, Davenport R, Manson J, McNeill J, Davies C, Renfrew I, Rothman M et al. ( 2011 ) . Cardiac dysfunction after trauma: A real and present danger . BRITISH JOURNAL OF SURGERY . vol. 98 , 7 - 8 .

Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, Hart D, Pearse R et al. ( 2011 ) . Point of care diagnostics for the rapid identification of acute traumatic coagulopathy and prediction of massive trauma haemorrhage . BRITISH JOURNAL OF SURGERY . vol. 98 , 7 - 7 .

Spoors C, Rourke C, Manson J, De'Ath H, Raza I, Khan S, Davenport R, Brohi K ( 2011 ) . Rotem indices of platelet function in acute traumatic coagulopathy . BRITISH JOURNAL OF SURGERY . vol. 98 , 8 - 8 .

Manson J, Davenport R, Coates A, De'Ath H, Spoors C, Khan S, Raza I, Rourke C et al. ( 2011 ) . Trauma: Characterising the cytokine response to tissue damage . BRITISH JOURNAL OF SURGERY . vol. 98 , 22 - 22 .

Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G et al. ( 2011 ) . The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial . LANCET vol. 377 , ( 9771 ) 1096 - 1101 .

Stannard A, Brohi K, Tai N ( 2011 ) . Vascular injury in the United Kingdom . Perspectives in Vascular Surgery and Endovascular Therapy vol. 23 , ( 1 ) 27 - 33 .

Khan S, Brohi K, Davenport R, Raza I, Manson J, West A, De'Ath H, Spoors C et al. ( 2011 ) . A major haemorrhage protocol improves blood product administration and wastage compared to traditional massive transfusion protocols . JOURNAL OF THROMBOSIS AND HAEMOSTASIS vol. 9 , 691 - 692 .

Manson J, Davenport R, Coates A, Rourke C, De'ath HD, Spoors C, Khan S, Raza I et al. ( 2011 ) . DEMONSTRATING THE HUMAN CYTOKINE RESPONSE TO TISSUE DAMAGE AFTER TRAUMATIC INJURY . SHOCK vol. 36 , 23 - 23 .

Raza I, Davenport R, Brohi K, Rourke C, Platton S, Khan S, De'Ath H, Spoors C et al. ( 2011 ) . Dilutional coagulopathy following blood transfusion in trauma . JOURNAL OF THROMBOSIS AND HAEMOSTASIS vol. 9 , 692 - 693 .

Frith D, Baptista ML, Cohen MJ, Pearse R, Thiemermann C, Brohi K ( 2011 ) . EXPERIMENTAL ACUTE TRAUMATIC COAGULOPATHY: INITIATED BY HYPOPERFUSION, MODULATED BY THE PROTEIN C PATHWAY . SHOCK vol. 36 , 16 - 17 .

Frith D, Baptista ML, Cohen M, Pearse R, Thiemermann C, Brohi K ( 2011 ) . Experimental acute traumatic coagulopathy is due to systemic activation of protein c during hypoperfusion . JOURNAL OF THROMBOSIS AND HAEMOSTASIS vol. 9 , 481 - 481 .

Curry NS, Rourke C, Khan S, Kingsland SA, Allard S, Pasi J, Brohi K, Stanworth S ( 2011 ) . Fibrinogen replacement for major haemorrhage in trauma - an <i>in</i>-<i>vitro</i> study . BRITISH JOURNAL OF HAEMATOLOGY . vol. 153 , 2 - 2 .

Curry NS, Rourke C, Khan S, Beavis J, Kingsland S, Brohi K, Stanworth SJ ( 2011 ) . Fibrinogen replacement in traumatic bleeding . JOURNAL OF THROMBOSIS AND HAEMOSTASIS vol. 9 , 938 - 938 .

Davenport R, Curry N, Manson J, De'Ath H, Coates A, Rourke C, Pearse R, Stanworth S et al. ( 2011 ) . Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2 . J Trauma vol. 70 , ( 1 ) 90 - 95 .

Raza I, Davenport R, Rourke C, Platton S, Manson J, Spoors C, De'Ath H, Khan S et al. ( 2011 ) . Occult activation of fibrinolysis in trauma . JOURNAL OF THROMBOSIS AND HAEMOSTASIS vol. 9 , 848 - 848 .

Spoors CM, Davenport R, De'Ath H, Khan S, Manson J, Raza I, Rourke C, Johansson P et al. ( 2011 ) . Platelet function in trauma measured by multiple electrode aggregometry . JOURNAL OF THROMBOSIS AND HAEMOSTASIS vol. 9 , 799 - 799 .

Curry NS, Raja A, Brohi K, Gaarder T, Johansson PI, Stanworth SJ, Harrison P ( 2011 ) . Procoagulant microvesicles are elevated in acute traumatic injury . JOURNAL OF THROMBOSIS AND HAEMOSTASIS vol. 9 , 895 - 895 .

Chana MS, Manson J, Davenport R, De'ath HD, Spoors C, Raza I, Khan S, Coates A et al. ( 2011 ) . TIME COURSE OF LACTATE CLEARANCE IN TRAUMA AND ITS RELEVANCE TO OUTCOMES . SHOCK vol. 36 , 10 - 11 .

De'Ath H, Manson J, Rourke C, Davenport R, Goh N, Renfrew I, Davies C, Rothman M et al. ( 2011 ) . TRAUMA INDUCED SECONDARY CARDIAC INJURY IS ASSOCIATED WITH ACUTE INFLAMMATION . SHOCK vol. 36 , 12 - 12 .

Curry N, Hopewell S, Doree C, Hyde C, Brohi K, Stanworth S ( 2011 ) . The acute management of trauma hemorrhage: a systematic review of randomized controlled trials . CRIT CARE vol. 15 , ( 2 ) Article R92 ,

De' Ath HD, Rourke C, Manson J, Davenport R, Khan S, Raza I, Spoors C, Davies C et al. ( 2011 ) . Trauma induced secondary cardiac injury . EUROPEAN HEART JOURNAL vol. 32 , 726 - 726 .

Brohi K, Plani F, Moeng M, Riou B, Goosen J, Pretorious J, Hardiman Y, Levy H ( 2010 ) . MULTICENTER RANDOMIZED CONTROLLED TRIAL TRA-204 TO EVALUATE THE SAFETY AND EFFICACY OF MP4OX IN LACTATE CLEARANCE FOLLOWING TRAUMA HEMORRHAGE . CRITICAL CARE MEDICINE . vol. 38 , U227 - U227 .

Frith D, Stanworth S, Gaarder C, Maegele M, Goslings C, Johansson P, Allard S, Cohen M et al. ( 2010 ) . Acute traumatic coagulopathy is dependent upon injury load and shock . BRITISH JOURNAL OF SURGERY vol. 97 , 39 - 40 .

Thomas D, Wee M, Clyburn P, Walker I, Brohi K, Collins P, Doughty H, Isaac J et al. ( 2010 ) . Blood transfusion and the anaesthetist: management of massive haemorrhage . Anaesthesia vol. 65 , ( 11 ) 1153 - 1161 .

Duchesne JC, McSwain NE, Cotton BA, Hunt JP, Dellavolpe J, Lafaro K, Marr AB, Gonzalez EA et al. ( 2010 ) . Damage control resuscitation: the new face of damage control . J Trauma vol. 69 , ( 4 ) 976 - 990 .

Frith D, Goslings JC, Gaarder C, Maegele M, Cohen MJ, Allard S, Johansson PI, Stanworth S et al. ( 2010 ) . Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations . J Thromb Haemost vol. 8 , ( 9 ) 1919 - 1925 .

Cohen MJ, Carles M, Brohi K, Calfee CS, Rahn P, Call MS, Chesebro BB, West MA et al. ( 2010 ) . Early Release of Soluble Receptor for Advanced Glycation Endproducts After Severe Trauma in Humans . JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE . vol. 68 , 1273 - 1278 .

Frith D, Brohi K ( 2010 ) . The acute coagulopathy of trauma shock: clinical relevance . Surgeon vol. 8 , ( 3 ) 159 - 163 .

Curry N, Raja A, Hughes T, Black J, Pullinger R, Davenport R, Brohi K, Stanworth S ( 2010 ) . A prospective observational study evaluating changes in coagulation parameters in trauma admissions . BRITISH JOURNAL OF HAEMATOLOGY . vol. 149 , 10 - 10 .

Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K et al. ( 2010 ) . Circulating mitochondrial DAMPs cause inflammatory responses to injury . Nature vol. 464 , ( 7285 ) 104 - 107 .

Davenport RA, Tai N, West A, Bouamra O, Aylwin C, Woodford M, McGinley A, Lecky F et al. ( 2010 ) . A major trauma centre is a specialty hospital not a hospital of specialties . Br J Surg vol. 97 , ( 1 ) 109 - 117 .

Bouillon B, Brohi K, Hess JR, Holcomb JB, Parr MJ, Hoyt DB ( 2010 ) . Educational initiative on critical bleeding in trauma: Chicago, July 11-13, 2008 . J Trauma vol. 68 , ( 1 ) 225 - 230 .

Konig TC, Davenport R, Sapsford W, Walsh MS, Brohi K, Tai NRM ( 2010 ) . Emergent Thoracotomy for Blunt Trauma-Is the Outcome so Bad? . International Journal of Surgery vol. 8 , ( 7 )

Stanworth SJ, Morris TP, Gaarder C, Goslings JC, Maegele M, Cohen MJ, Konig TC, Davenport RA et al. ( 2010 ) . Reappraising the concept of massive transfusion in trauma . CRIT CARE vol. 14 , ( 6 ) Article R239 ,

Frith D, Cohen M, Pearse R, Thiemermann C, Brohi K ( 2010 ) . Rodent coagulation responses to trauma and haemorrhagic shock . INFLAMMATION RESEARCH . vol. 59 , S26 - S27 .

Mossadegh S, Leahman H, Brohi K, Sapsford W, Tai N ( 2010 ) . Splenic injury in a major British trauma centre: evolution in therapy over time . BRITISH JOURNAL OF SURGERY . vol. 97 , 65 - 65 .

Durai R, Agrawal R, Piper K, Brohi K ( 2009 ) . Wegener's granulomatosis presenting as an abdominal aortic aneurysm: a case report . Cases J vol. 2 ,

O'reilly D, Brohi K ( 2009 ) . Effects of terrorism on the healthcare community . 45 - 58 .

Chesebro BB, Rahn P, Carles M, Esmon CT, Xu J, Brohi K, Frith D, Pittet J-F et al. ( 2009 ) . Increase in activated protein C mediates acute traumatic coagulopathy in mice . Shock vol. 32 , ( 6 ) 659 - 665 .

Cohen MJ, Bir N, Rahn P, Dotson R, Brohi K, Chesebro BB, Mackersie R, Carles M et al. ( 2009 ) . Protein C Depletion Early After Trauma Increases the Risk of Ventilator-Associated Pneumonia . JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE . vol. 67 , 1176 - 1181 .

Brohi K ( 2009 ) . Trauma induced coagulopathy . J R Army Med Corps vol. 155 , ( 4 ) 320 - 322 .

Brohi K ( 2009 ) . Diagnosis and management of coagulopathy after major trauma . Br J Surg vol. 96 , ( 9 ) 963 - 964 .

Bent CL, Fotiadis N, Renfrew I, Walsh M, Brohi K, Kyriakides C, Matson M ( 2009 ) . Total percutaneous aortic repair: midterm outcomes . Cardiovasc Intervent Radiol vol. 32 , ( 3 ) 449 - 454 .

Davenport RA, Brohi K ( 2009 ) . Coagulopathy in trauma patients: importance of thrombocyte function? . Curr Opin Anaesthesiol vol. 22 , ( 2 ) 261 - 266 .

König TC, Morris T, Gaarder C, Maegele M, Goslings C, Allard S, Cohen M, Pittet JF et al. ( 2009 ) . Redefining massive transfusion . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine vol. 17 , ( Suppl 1 )

Davenport RA, Tai N, West A, Bouamra O, Aylwin C, Woodford M, McGinley A, Lecky F et al. ( 2009 ) . The Trauma Centre: a specialty hospital, not a hospital of specialties . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine vol. 17 , ( Suppl 1 )

Frith D, Chesebro B, Pittet JF, Cohen MJ, Thiemermann C, Pearse R, Brohi K ( 2009 ) . ACUTE TRAUMATIC COAGULOPATHY IS DRIVEN BY SYSTEMIC HYPOPERFUSION INDEPENDENT OF HYPOTENSION AND HAEMORRHAGE VOLUME . SHOCK . vol. 32 , 9 - 9 .

Frith D, Stanworth S, Gaarder C, Maegele M, Goslings C, Johansson PI, Allard S, Cohen MJ et al. ( 2009 ) . Acute traumatic coagulopathy is dependent on both injury severity and shock: clinical and experimental validation . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 7 , 290 - 290 .

Davenport RA, Allard S, Coates A, Thiemermann C, Pasi J, Pearse R, Brohi K ( 2009 ) . Acute traumatic coagulopathy: functional characterisation by rotational thrombolelastometry . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 7 , 1163 - 1163 .

Band RA, Bilski TR, Bowyer MW, Brohi K, Brooks A, Burris D, Carr BG, Carr SR et al. ( 2009 ) . Contributeurs . Traumatologie d'urgence , Elsevier

Cohen MJ, Brohi K, Calfee CS, Rahn P, Chesebro BB, Christiaans SC, Carles M, Howard M et al. ( 2009 ) . Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion . CRIT CARE vol. 13 , ( 6 ) Article R174 ,

Davenport R, Coates A, Allard S, Pasi J, MacCallum P, Stanworth S, Thiemermann C, Pearse R et al. ( 2009 ) . TRAUMA HAEMORRHAGE: EVOLVING ROLE OF ROTEM FOR PREDICTING TRANSFUSION REQUIREMENTS . SHOCK . vol. 32 , 15 - 15 .

Greaves P, Konig T, Barber C, Barroso AF, Weaver A, Brohi K, Allard S ( 2009 ) . Use of 'massive transfusion packs' at a major trauma centre . BRITISH JOURNAL OF HAEMATOLOGY . vol. 145 , 80 - 80 .

Hess JR, Brohi K, Dutton RP, Hauser CJ, Holcomb JB, Kluger Y, Mackway-Jones K, Parr MJ et al. ( 2008 ) . The Coagulopathy of Trauma: A Review of Mechanisms . J TRAUMA vol. 65 , ( 4 ) 748 - 754 .

Parr MJ, Bouillon B, Brohi K, Dutton RP, Hauser CJ, Hess JR, Holcomb JB, Kluger Y et al. ( 2008 ) . Traumatic Coagulopathy: Where are the Good Experimental Models? . J TRAUMA vol. 65 , ( 4 ) 766 - 771 .

Brohi K ( 2008 ) . The Utstein template for uniform reporting of data following major trauma: a valuable tool for establishing a pan-European dataset . Scand J Trauma Resusc Emerg Med vol. 16 ,

Kortbeek JB, Al Turki SA, Ali J, Antoine JA, Bouillon B, Brasel K, Brenneman F, Brink PR et al. ( 2008 ) . Advanced Trauma Life Support, 8th edition, the evidence for change . J TRAUMA vol. 64 , ( 6 ) 1638 - 1650 .

Davenport R, Aylwin C, Ward E, Goosen J, McLeod J, Brohi K, Walsh M, Tai N ( 2008 ) . A performance improvement programme aids analysis of potentially preventable death from trauma: A UK inner-city hospital experience . Injury extra. vol. 39 , ( 5 )

Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF ( 2008 ) . Acute coagulopathy of trauma: Hypoperfusion induces systemic anticoagulation and hyperfibrinolysis . JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE . vol. 64 , 1211 - 1217 .

Davies E, Davenport R, Brohi K, Tai N, Walsh M ( 2008 ) . Anatomy and mechanism of injury of fatal vascular trauma: An inner city hospital's experience . Injury extra. vol. 39 , ( 5 )

Ganter MT, Cohen MJ, Brohi K, Chesebro BB, Staudenmayer KL, Rahn P, Christiaans SC, Bir ND et al. ( 2008 ) . Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma? . ANN SURG vol. 247 , ( 2 ) 320 - 326 .

Aylwin CJ, Brohi K, Davies GD, Walsh MS ( 2008 ) . Pre-hospital and in-hospital thoracostomy: indications and complications . Ann R Coll Surg Engl vol. 90 , ( 1 ) 54 - 57 .

Brohi K ( 2008 ) . Shock and blood transfusion . Bailey &amp; Love's Short Practice of Surgery ,

Frith D, Chesebro B, Patel N, Thiemermann C, Brohi K, Cohen M, Pearse R ( 2008 ) . Towards a mouse model for acute coagulopathy of trauma/shock . SHOCK . vol. 29 , 6 - 6 .

Brohi K, Cohen MJ, Davenport RA ( 2007 ) . Acute coagulopathy of trauma: mechanism, identification and effect . Curr Opin Crit Care vol. 13 , ( 6 ) 680 - 685 .

Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet J-F ( 2007 ) . Early Coagulopathy After Traumatic Brain Injury: The Role of Hypoperfusion and the Protein C Pathway . Journal of Trauma and Acute Care Surgery vol. 63 , ( 6 ) 1254 - 1262 .

Bent CL, Matson MB, Sobeh M, Renfrew I, Uppal R, Walsh M, Brohi K, Kyriakides C ( 2007 ) . Endovascular management of acute blunt traumatic thoracic aortic injury: a single center experience . J Vasc Surg vol. 46 , ( 5 ) 920 - 927 .

Brohi K ( 2007 ) . Trauma care: The future and how to get there . Australasian Emergency Care vol. 10 , ( 4 )

Ganter MT, Brohi K, Cohen MJ, Shaffer LA, Walsh MC, Stahl GL, Pittet JF ( 2007 ) . Role of the alternative pathway in the early complement activation following major trauma . SHOCK vol. 28 , ( 1 ) 29 - 34 .

Brohi K ( 2007 ) . Trauma specialist centres . ANN ROY COLL SURG vol. 89 , ( 5 ) 252 - 253 .

Kheirabadi BS, Crissey JM, Deguzman R, Holcomb JB ( 2007 ) . In Vivo Bleeding Time and In Vitro Thrombelastography Measurements are Better Indicators of Dilutional Hypothermic Coagulopathy Than Prothrombin Time . Journal of Trauma and Acute Care Surgery vol. 62 , ( 6 ) 1352 - 1361 .

Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF ( 2007 ) . Acute traumatic coagulopathy: Initiated by hypoperfusion - Modulated through the protein C pathway? . ANN SURG vol. 245 , ( 5 ) 812 - 818 .

Davenport R, West A, Walsh M, Brohi K ( 2007 ) . A dedicated trauma service reduces hospital stay in critically injured patients . Injury extra. vol. 38 , ( 4 )

Bhatti M, Matson M, Renfrew I, Kyriakides C, Brohi K ( 2007 ) . Endovascular management of extremity vascular injuries . Injury extra. vol. 38 , ( 4 )

Aylwin CJ, König TC, Brennan NW, Shirley PJ, Davies G, Walsh MS, Brohi K ( 2006 ) . Reduction in critical mortality in urban mass casualty incidents: analysis of triage, surge, and resource use after the London bombings on July 7, 2005 . Lancet vol. 368 , ( 9554 ) 2219 - 2225 .

Rickard MJFX, Brohi K, Bautz PC ( 2005 ) . Pancreatic and duodenal injuries: Keep it simple . ANZ J SURG vol. 75 , ( 7 ) 581 - 586 .

Brohi K, Healy M, Fotheringham T, Chan O, Aylwin C, Whitley S, Walsh M ( 2005 ) . Helical computed tomographic scanning for the evaluation of the cervical spine in the unconscious, intubated trauma patient . J Trauma vol. 58 , ( 5 ) 897 - 901 .

Brohi K, Singh J, Heron M, Coats T ( 2003 ) . Acute traumatic coagulopathy . J TRAUMA vol. 54 , ( 6 ) 1127 - 1130 .

( 2003 ) . Guidelines for initial . Injury vol. 34 , ( 6 ) 405 - 425 .

Walsh M, Brohi K, Cord-Udy C ( 2003 ) . Splenectomy after major trauma: could more spleens be saved? . ANN ROY COLL SURG vol. 85 , ( 3 ) 221 - 222 .

Kyriakides C, Bicknell CD, Walsh M, Brohi K, Nott D, Cheshire NJ ( 2003 ) . Minimal-access aortic surgery: techniques and early experience . BRITISH JOURNAL OF SURGERY . vol. 90 , 495 - 496 .

Brohi K ( 2003 ) . Use of the internet to improve trauma care . Trauma vol. 5 , ( 2 ) 117 - 122 .

Henderson KIM, Coats TJ, Hassan TB, Brohi K ( 2002 ) . Audit of time to emergency trauma laparotomy . British Journal of Surgery vol. 87 , ( 4 ) 472 - 476 .

Brohi K, Wilson-Macdonald J ( 2000 ) . Evaluation of Unstable Cervical Spine Injury: A 6-Year Experience . Journal of Trauma and Acute Care Surgery . vol. 49 , 76 - 80 .

Brohi K, Dhadly P, Mauger J ( 1999 ) . LETTERS TO THE EDITOR . Journal of Trauma and Acute Care Surgery vol. 46 , ( 4 )

Ravalia A, Brohi K ( 1995 ) . Fractured neck of femur in a patient with a complicated medical condition . British Journal of Hospital Medicine vol. 53 , ( 11 )