Skip to main content
Research

Publications: Prof Gareth Sanger

Andrews PLR, Cai W, Rudd JA, Sanger GJ ( 2021 ) . COVID-19, nausea, and vomiting . Journal of Gastroenterology and Hepatology (Australia) vol. 36 , ( 3 ) 646 - 656 .
Makwana R, Loy J, Adebibe M, Devalia K, Andrews PL, Sanger GJ ( 2021 ) . Copeptin, a surrogate marker of arginine<sup>8</sup> vasopressin, has no ability to modulate human and mouse gastric motility . European Journal of Pharmacology vol. 892 ,
Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA et al. ( 2021 ) . International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function . Pharmacological Reviews vol. 73 , ( 1 ) 310 - 520 .
Davis MP, Sanger GJ ( 2021 ) . The Benefits of Olanzapine in Palliating Symptoms . Current Treatment Options in Oncology vol. 22 , ( 1 )
Sanger G, Andrews P ( 2020 ) . Emesis . Encyclopedia of Molecular Pharmacology. , Editors: Offermanns, S, Rosenthal, W , In: Offermanns S., Rosenthal W. (eds) Encyclopedia of Molecular Pharmacology. Springer, Cham
Straface M, Makwana R, Palmer A, Rombolà L, Aleong JC, Morrone LA, Sanger GJ ( 2020 ) . Inhibition of neuromuscular contractions of human and rat colon by bergamot essential oil and linalool: Evidence to support a therapeutic action . Nutrients vol. 12 , ( 5 )
Choudhry N, Scott F, Edgar M, Sanger GJ, Kelly P ( 2020 ) . Reversal of Pathogen-Induced Barrier Defects in Intestinal Epithelial Cells by Contra-pathogenicity Agents . Digestive Diseases and Sciences
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF et al. ( 2019 ) . THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors . British Journal of Pharmacology vol. 176 , ( S1 ) S21 - S141 .
Cibert-Goton V, Kung VWS, McGuire C, Hockley JRF, Tranter MM, Dogra H, Belai A, Blackshaw LA et al. ( 2019 ) . Functional and anatomical deficits in visceral nociception with age: a mechanism of silent appendicitis in the elderly? . Pain vol. 161 , ( 4 ) 773 - 786 .
Straface M, Makwana R, Rombola L, Chinaleong J, Morrone LA, Sanger GJ ( 2019 ) . Bergamot essential oil and its constituent linalool, inhibit cholinergically-mediated contractions of human and rat isolated colon . NEUROGASTROENTEROLOGY AND MOTILITY . Conference: Neurogastroenterology vol. 31 ,
Palmer A, Straface M, Chin-Aleong J, Knowles C, Sanger GJ ( 2019 ) . Isolation and culture of primary myenteric neurons and glial cells from human colon: The effects of different concentrations of nerve growth factor . NEUROGASTROENTEROLOGY AND MOTILITY . Conference: Neurogastroenterology vol. 31 ,
Makwana R, Elahi S, Adebibe M, Loy J, Sanger GJ ( 2019 ) . Low concentrations of arginine vasopressin (AVP) act at V1A receptors in human stomach to increase frequency and amplitude of spontaneous rhythmic contractions: Role in nausea . NEUROGASTROENTEROLOGY AND MOTILITY . Conference: Neurogastroenterology ( Lisbon, Portugal ) from: 05/09/2019 to: 07/09/2019 , vol. 31 ,
Scott F, Elahi S, Adebibe M, Parampalli U, Mannur K, Góralczyk A, Sanger GJ ( 2019 ) . Farnesoid X receptor - a molecular predictor of weight loss after vertical sleeve gastrectomy? . Obesity Science and Practice vol. 5 , ( 3 ) 273 - 280 .
Ruffle JK, Patel A, Giampietro V, Howard MA, Sanger GJ, Andrews PLR, Williams SCR, Aziz Q et al. ( 2019 ) . Functional brain networks and neuroanatomy underpinning nausea severity can predict nausea susceptibility using machine learning . Journal of Physiology vol. 597 , ( 6 ) 1517 - 1529 .
SANGER GJ, BROAD J, KUNG V, Palmer A, ELAHI S, Karami A, Darreh-Shori T, Ahmed S et al. ( 2018 ) . Changes in neuromuscular structure and functions of human colon during ageing are region-dependent . Gut
SANGER GJ, Andrews PLR ( 2018 ) . A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research . Front. Pharmacol. 9:913. vol. 9 , Article 913 ,
Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL et al. ( 2017 ) . THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview . British Journal of Pharmacology vol. 174 , S1 - S16 .
Liszt KI, Ley JP, Lieder B, Behrens M, Stöger V, Reiner A, Hochkogler CM, Köck E et al. ( 2017 ) . Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells . Proceedings of the National Academy of Sciences vol. 114 , ( 30 ) E6260 - E6269 .
Sanger GJ, Pasricha PJ ( 2017 ) . Investigational drug therapies for the treatment of gastroparesis . Expert Opin Investig Drugs vol. 26 , ( 3 ) 331 - 342 .
Sanger GJ, Broad J, Callaghan B, Furness JB ( 2016 ) . Ghrelin and Motilin Control Systems in GI Physiology and Therapeutics . vol. 239 , SpringerLink
McGuire C, Boundouki G, Hockley JR, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J et al. ( 2016 ) . Ex vivo study of human visceral nociceptors . GUT Article 27654583 , 1 - 11 .
Broad J, Maurel D, Kung VWS, Hicks GA, Schemann M, Barnes MR, Kenakin TP, Granier S et al. ( 2016 ) . Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design . Scientific Reports vol. 6 ,
Sanger GJ ( 2016 ) . Chronic constipation: improved understanding offers a new therapeutic approach . J Physiol vol. 594 , ( 15 ) 4085 - 4087 .
Broad J, Kung V, Karami A, Darreh-Shori T, Knowles C, Sanger GJ ( 2016 ) . Region-specific increase in colonic function of choline acetyltransferase in the elderly . NEUROGASTROENTEROLOGY AND MOTILITY . Conference: Neurogastro Motility vol. 28 , 102 - 102 .
Hellström PM, Tack J, Johnson LV, Hacquoil K, Barton ME, Richards DB, Alpers DH, Sanger GJ et al. ( 2016 ) . The pharmacodynamics, safety and pharmacokinetics of single doses of the motilin agonist, camicinal, in type 1 diabetes mellitus with slow gastric emptying . British Journal of Pharmacology vol. 173 , ( 11 ) 1768 - 1777 .
Broad J, Takahashi N, Tajimi M, Sudo M, Góralczyk A, Parampalli U, Mannur K, Yamamoto T et al. ( 2016 ) . RQ-00201894: A motilin receptor agonist causing long-lasting facilitation of human gastric cholinergically-mediated contractions . Journal of Pharmacological Sciences vol. 130 , ( 2 ) 60 - 65 .
Sanger GJ, Furness JB ( 2016 ) . Ghrelin and motilin receptors as drug targets for gastrointestinal disorders . Nature Reviews Gastroenterology and Hepatology vol. 13 , ( 1 ) 38 - 48 .
Kung V, Broad J, Machesney M, THAHA MA, Knowles CH, Sanger G ( 2015 ) . Preoperative chemotherapy does not appear to have short-term effects on human rectal neuromuscular functions . Gut . Conference: Digestive Disorders Federation 2015 ( London, UK ) from: 22/06/2015 to: 26/06/2015 , vol. Suppl 1 , A584 - A584 .
Broad J, Callaghan B, Sanger GJ, Brock JA, Furness JB ( 2015 ) . Analysis of the ghrelin receptor-independent vascular actions of ulimorelin . European Journal of Pharmacology vol. 752 , 34 - 39 .
Farmer AD, Ban VF, Coen SJ, Sanger GJ, Barker GJ, Gresty MA, Giampietro VP, Williams SC et al. ( 2015 ) . Visually induced nausea causes characteristic changes in cerebral, autonomic and endocrine function in humans . Journal of Physiology vol. 593 , ( 5 ) 1183 - 1196 .
Broad J, Hughes F, Chin-Aleong J, Sifrim D, Sanger GJ ( 2014 ) . Regionally dependent neuromuscular functions of motilin and 5-HT₄ receptors in human isolated esophageal body and gastric fundus . Neurogastroenterol Motil vol. 26 , ( 9 ) 1311 - 1322 .
Broad J, Góralczyk A, Mannur K, Dukes GE, Sanger GJ ( 2014 ) . Drugs acting at 5-HT4 , D2 , motilin, and ghrelin receptors differ markedly in how they affect neuromuscular functions in human isolated stomach . Neurogastroenterol Motil vol. 26 , ( 6 ) 851 - 861 .
Kung VWS, Broad J, Sanger GJ, Knowles CH ( 2014 ) . Gender- and regionally-specific decline in colonic neuromuscular activity with advanced age . BRITISH JOURNAL OF SURGERY . vol. 101 , 3 - 3 .
Sanger GJ ( 2014 ) . The relationship between symptom improvement and gastric emptying in the treatment of gastroparesis: remember the pharmacology . Am J Gastroenterol vol. 109 , ( 3 ) 444 - 445 .
Sanger GJ ( 2014 ) . Ghrelin and motilin receptor agonists: time to introduce bias into drug design . Neurogastroenterol Motil vol. 26 , ( 2 ) 149 - 155 .
Andrews PLR, Sanger GJ ( 2014 ) . Nausea and the quest for the perfect anti-emetic . EUROPEAN JOURNAL OF PHARMACOLOGY vol. 722 , 108 - 121 .
Andrews PLR, Sanger GJ ( 2014 ) . Nausea and the quest for the perfect anti-emetic . Eur J Pharmacol vol. 722 , 108 - 121 .
Sanger GJ ( 2013 ) . Ghrelin and motilin receptor agonists: a long and winding misconception . Neurogastroenterol Motil vol. 25 , ( 12 )
Sanger GJ, Wang Y, Hobson A, Broad J ( 2013 ) . Motilin: towards a new understanding of the gastrointestinal neuropharmacology and therapeutic use of motilin receptor agonists . Br J Pharmacol vol. 170 , ( 7 ) 1323 - 1332 .
Broad J, Kung VWS, Boundouki G, Aziz Q, De Maeyer JH, Knowles CH, Sanger GJ ( 2013 ) . Cholinergic interactions between donepezil and prucalopride in human colon: potential to treat severe intestinal dysmotility . Br J Pharmacol vol. 170 , ( 6 ) 1253 - 1261 .
Sanger GJ, Broad J, Andrews PLR ( 2013 ) . The relationship between gastric motility and nausea: gastric prokinetic agents as treatments . Eur J Pharmacol vol. 715 , ( 1-3 ) 10 - 14 .
Broad J, Sanger GJ ( 2013 ) . The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin . Br J Pharmacol vol. 168 , ( 8 ) 1859 - 1867 .
Javid FA, Bulmer DC, Broad J, Aziz Q, Dukes GE, Sanger GJ ( 2013 ) . Anti-emetic and emetic effects of erythromycin in Suncus murinus: role of vagal nerve activation, gastric motility stimulation and motilin receptors . Eur J Pharmacol vol. 699 , ( 1-3 ) 48 - 54 .
Izzo AA ( 2013 ) . Novel insights which may translate into treatments for irritable bowel syndrome . Front Pharmacol vol. 4 ,
Webb DL, Rudholm-Feldreich T, Gillberg L, Halim MA, Theodorsson E, Sanger GJ, Campbell CA, Boyce M et al. ( 2013 ) . The type 2 CCK/gastrin receptor antagonist YF476 acutely prevents NSAID-induced gastric ulceration while increasing iNOS expression . Naunyn-Schmiedeberg's Archives of Pharmacology vol. 386 , ( 1 ) 41 - 49 .
Sanger GJ, Broad J, Kung V, Knowles CH ( 2013 ) . Translational neuropharmacology: the use of human isolated gastrointestinal tissues . Br J Pharmacol vol. 168 , ( 1 ) 28 - 43 .
Sanger GJ ( 2012 ) . Motilin receptor neuropharmacology: revised understanding . Curr Opin Pharmacol vol. 12 , ( 6 ) 641 - 646 .
Sanger GJ ( 2012 ) . New target profiling for gastrointestinal disorders: where are we going? . Curr Opin Pharmacol vol. 12 , ( 6 ) 629 - 631 .
Broad J, Mukherjee S, Samadi M, Martin JE, Dukes GE, Sanger GJ ( 2012 ) . Regional- and agonist-dependent facilitation of human neurogastrointestinal functions by motilin receptor agonists . Br J Pharmacol vol. 167 , ( 4 ) 763 - 774 .
Ng KS, Andrews P, Chua YC, Ban VF, Gresty M, Coen SJ, Sanger GJ, Williams SC et al. ( 2012 ) . Psychophysiological markers and the brain processing of nausea in healthy humans using a novel virtual reality video . NEUROGASTROENTEROLOGY AND MOTILITY vol. 24 , 39 - 40 .
Ng KS, Coen SJ, Chua YC, Ban VF, Gresty MA, Sanger GJ, Williams SC, Barker GJ et al. ( 2012 ) . STUDIES OF THE PSYCHOPHYSIOLOGICAL MARKERS AND THE BRAIN PROCESSING OF NAUSEA IN HEALTHY HUMANS USING A NOVEL VIRTUAL REALITY VIDEO . GUT vol. 61 , A317 - A318 .
Broad J, Andrews PL, Sanger GJ ( 2012 ) . VASOPRESSIN CONTRACTS HUMAN ISOLATED STOMACH MUSCLE: POSSIBLE ROLE IN NAUSEA? . GUT vol. 61 , A297 - A298 .
Sung EZ, Arasaradnam RP, Jarvie EM, James S, Goodyear SJ, Borman RA, Snead D, SANGER GJ et al. ( 2012 ) . Effects of neo-adjuvant chemotherapy for oesophago-gastric cancer on neuro-muscular gastric function . Mol Biol Rep vol. 39 , ( 12 ) 9989 - 9994 .
Leming S, Broad J, Cozens SJ, Otterson M, Winchester W, Lee K, Dukes GE, Sanger GJ ( 2011 ) . GSK962040: a small molecule motilin receptor agonist which increases gastrointestinal motility in conscious dogs . Neurogastroenterol Motil vol. 23 , ( 10 ) 958 - e410 .
Sanger GJ, Holbrook JD, Andrews PLR ( 2011 ) . The translational value of rodent gastrointestinal functions: a cautionary tale . Trends Pharmacol Sci vol. 32 , ( 7 ) 402 - 409 .
Ng K, Chua Y, Ban VF, Gresty M, Coen S, Sanger G, Williams S, Barker G et al. ( 2011 ) . Identifying human biomarkers of nausea for refining animal studies on emesis . Gut . vol. 60 ,
Sanger GJ, Broad J, Alpers DH ( 2011 ) . Translation of Motilin and Ghrelin Receptor Agonists into Drugs for Gastrointestinal Disorders . Peptide Drug Discovery and Development. Translational Research in Academia and Industry , Editors: Castanho, MARB, Santos, NC , Wiley VCH
Sanger GJ, Chang L, Bountra C, Houghton LA ( 2010 ) . Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders . Therap Adv Gastroenterol vol. 3 , ( 5 ) 291 - 305 .
Broad J, Leming S, Matthews KL, Briggs M, Otterson M, Winchester W, Cozens SJ, Dukes GE et al. ( 2010 ) . GSK962040: a small molecule motilin receptor agonist which increases gastrointestinal (GI) motility in dogs . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 22 , 84 - 84 .
Falken Y, Hellstrom PM, Sanger GJ, Dewit O, Dukes G, Gryback P, Holst JJ, Naslund E ( 2010 ) . Actions of prolonged ghrelin infusion on gastrointestinal transit and glucose homeostasis in humans . NEUROGASTROENT MOTIL vol. 22 , ( 6 ) e192 - e200 .
Broad J, Boundouki G, Knowles CH, Sanger GJ ( 2010 ) . CHARACTERISATION OF MOTOR NERVE RESPONSES TO ELECTRICAL FIELD STIMULATION IN HUMAN ISOLATED COLON . GUT . vol. 59 , A140 - A140 .
Ng K, Chua Y, Gresty M, Marreddy U, Williams S, Barker G, Andrews P, Sanger G et al. ( 2010 ) . OC-072 Identification of psychophysiological biomarkers of nausea using a novel visual induction method . Gut . vol. 59 ,
Sanger GJ, Chang L, Bountra C, Houghton L ( 2010 ) . Challenges and Prospects for Pharmacotherapy in Functional Gastrointestinal Disorders . Ther Adv Gastroenterol vol. 3 , ( 5 ) 291 - 305 .
Sanger GJ, Quigley EMM ( 2010 ) . Constipation, IBS and the 5-HT<inf>4</inf> receptor: What role for prucalopride? . Clinical Medicine Insights: Gastroenterology vol. 3 , 21 - 33 .
Broad J, Mukherjee S, Boundouki G, Dukes GE, Sanger GJ ( 2010 ) . Different abilities of [Nle13]-motilin and the motilin receptor agonist GSK962040 to facilitate cholinergic and nitrergic activity in human isolated stomach . Neurogastroenterol Motil . vol. 22 (S1) ,
Ferens DM, Yin L, Bron R, Hunne B, Ohashi-Doi K, Kitchener PD, Sanger GJ, Witherington J et al. ( 2010 ) . Functional and in situ hybridisation evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors . Neuroscience vol. 166 , ( 2 ) 671 - 679 .
Broad J, Leming S, Matthews KL, Briggs M, Otterson M, Winchester W, Cozens SJ, Dukes GE et al. ( 2010 ) . GSK962040: a small molecule motilin receptor agonist which increases gastrointestinal (GI) motility in dogs . Neurogastroenterol Motil . vol. 23 , 958 - e410 .
Sanger GJ ( 2010 ) . Gastrointestinal pharmacology: challenges ahead . Front Pharm vol. 1 , 4 - 4 .
Ng K, Chua Y, Gresty M, Marreddy U, Williams S, Barker G, Andrews P, Sanger G et al. ( 2010 ) . Identification of psychophysiological biomarkers of nausea using a novel visual induction method . Gut . vol. 59 suppl 1 ,
Sanger GJ, Hellström PM, Näslund E ( 2010 ) . The hungry stomach: physiology, disease, and drug development opportunities . Front Pharmacol vol. 1 ,
Sanger GJ ( 2009 ) . Translating 5-HT receptor pharmacology . Neurogastroenterol Motil vol. 21 , ( 12 ) 1235 - 1238 .
Mitchell NA, Pepperell E, Ociepka S, Brown JD, Witherington J, Tuladhar B, Sanger GJ, Lee K et al. ( 2009 ) . 5-hydroxyindalpine, an agonist at the putative 5-HT<inf>1P</inf> receptor, has no activity on human recombinant monoamine receptors but accelerates distension-induced peristalsis in mouse isolated colon . Neurogastroenterology and Motility vol. 21 , ( 7 )
Bassil AK, Bourdu S, Townson KA, Wheeldon A, Jarvie EM, Zebda N, Abuin A, Grau E et al. ( 2009 ) . UDP-glucose modulates gastric function through P2Y<inf>14</inf> receptor-dependent and -independent mechanisms . American Journal of Physiology - Gastrointestinal and Liver Physiology vol. 296 , ( 4 )
Witherington J, Abberley L, Bellenie BR, Boatman R, Collis K, Dean DK, Gaiba A, Paul King N et al. ( 2009 ) . Aryl sulphonyl amides as potent agonists of the growth hormone secretagogue (ghrelin) receptor . Bioorganic and Medicinal Chemistry Letters vol. 19 , ( 3 ) 684 - 687 .
Holbrook JD, Gill CH, Zebda N, Spencer JP, Leyland R, Rance KH, Trinh H, Balmer G et al. ( 2009 ) . Characterisation of 5-HT3c, 5-HT3d and 5-HT3e receptor subunits: evolution, distribution and function . J Neurochem vol. 108 , ( 2 ) 384 - 396 .
SANGER GJ, Westaway SM, Brown SL, Fell SCM, Johnson CM, MacPherson DT, Mitchell DJ, Myatt JW et al. ( 2009 ) . Discovery of N-(3-Fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040): The first small molecule motilin receptor agonist clinical candidate . J Med Chem vol. 52 , 1180 - 1189 .
SANGER GJ, Westaway SM, Barnes AA, Macpherson DT, Muir AI, Jarvie EM, Bolton VN, Cellek S et al. ( 2009 ) . GSK962040: a small molecule, selective motilin receptor agonist, effective as a stimulant of human and rabbit gastrointestinal motility . Neurogastroenterology and Motility vol. 21 , 657 - 666 .
Sung EZH, Da Silva NF, Goodyear S, Mcternan PG, Sanger GJ, Nwokolo CU ( 2009 ) . Increased plasma ghrelin following infliximab in Crohn's disease . Alimentary Pharmacology and Therapeutics vol. 29 , ( 1 ) 83 - 89 .
Bassil AK, Taylor CM, Bolton VJN, Grey KM, Brown JD, Cutler L, Summerfield SG, Bruton G et al. ( 2009 ) . Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology . Br J Pharmacol vol. 158 , ( 1 ) 252 - 258 .
Shafton AD, Sanger GJ, Witherington J, Brown JD, Muir A, Butler S, Abberley L, Shimizu Y et al. ( 2009 ) . Oral administration of a centrally acting ghrelin receptor agonist to conscious rats triggers defecation . Neurogastroenterology and Motility vol. 21 , ( 1 ) 71 - 77 .
Bailey JM, Scott JS, Basilla JB, Bolton VJ, Boyfield I, Evans DG, Fleury E, Heightman TD et al. ( 2009 ) . The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor . Bioorg Med Chem Lett vol. 19 , ( 22 ) 6452 - 6458 .
Westaway SM, Sanger GJ ( 2009 ) . The identification and rationale for drugs which act at the motilin receptor . Progress in Medicinal Chemistry vol. 48 , 31 - 80 .
Westaway SM, Sanger GJ ( 2009 ) . The identification of and rationale for drugs which act at the motilin receptor . vol. 48 ,
Heightman TD, Conway E, Corbett DF, Macdonald GJ, Stemp G, Westaway SM, Celestini P, Gagliardi S et al. ( 2008 ) . Identification of small molecule agonists of the motilin receptor . Bioorganic and Medicinal Chemistry Letters vol. 18 , ( 24 ) 6423 - 6428 .
Westaway SM, Brown SL, Conway E, Heightman TD, Johnson CN, Lapsley K, Macdonald GJ, MacPherson DT et al. ( 2008 ) . The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor . Bioorganic and Medicinal Chemistry Letters vol. 18 , ( 24 ) 6429 - 6436 .
Jarvie EM, Cellek S, Sanger GJ ( 2008 ) . Potentiation by cholinesterase inhibitors of cholinergic activity in rat isolated stomach and colon . Pharmacological Research vol. 58 , ( 5-6 ) 297 - 301 .
Malik NM, Moore GBT, Kaur R, Liu YL, Wood SL, Morrow RW, Sanger GJ, Andrews PLR ( 2008 ) . Adaptive upregulation of gastric and hypothalamic ghrelin receptors and increased plasma ghrelin in a model of cancer chemotherapy-induced dyspepsia . Regulatory Peptides vol. 148 , ( 1-3 ) 33 - 38 .
Bolton VN, Bassil AK, Lee K, Sanger GJ ( 2008 ) . Inhibition by tianeptine of neuronally mediated contractions in the rat isolated gastrointestinal tract . Pharmacological Research vol. 57 , ( 5 ) 339 - 343 .
Sanger GJ, Lee K ( 2008 ) . Hormones of the gut-brain axis as targets for the treatment of upper gastrointestinal disorders . Nature Reviews Drug Discovery vol. 7 , ( 3 ) 241 - 254 .
Sanger GJ ( 2008 ) . Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases . Drug Discovery Today vol. 13 , ( 5-6 ) 234 - 239 .
Sanger GJ ( 2008 ) . 5-Hydroxytryptamine and the gastrointestinal tract: Where next? . Trends in Pharmacological Sciences vol. 29 , ( 9 ) 465 - 471 .
Bassil AK, Borman RA, Jarvie EM, McArthur-Wilson RJ, Thangiah R, Sung EZ, Lee K, Sanger GJ ( 2008 ) . Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon . Br J Pharmacol vol. 154 , 126 - 135 .
Sanger GJ, Alpers DH ( 2008 ) . Development of drugs for gastrointestinal motor disorders: translating science to clinical need . Neurogastroenterol Motil vol. 20 , 177 - 184 .
Sanger GJ, Lee K ( 2008 ) . Hormones of the gut-brain axis as targets for the treatment of upper gastrointestinal disorders . NATURE REVIEWS DRUG DISCOVERY vol. 7 , 242 - 254 .
Olsson C, Holbrook JD, Bompadre G, Jönsson E, Hoyle C, Sanger GJ, Holmgren S, Andrews PLR ( 2008 ) . Identification of genes for ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin . Gen Comparative Endocrinol vol. 155 , 217 - 226 .
Witherington J, Abberley L, Briggs MA, Collis K, Dean DK, Gaiba A, King PN, Kraus H et al. ( 2008 ) . Potent achiral agonists of the growth hormone secretatgogue (ghrelin) receptor. Part 2 – Lead Optimisation . Bioorg Med Chem Lett vol. 18 , 2203 - 2205 .
Cellek S, Thangiah R, Jarvie EM, Vivekanandan S, Lalude O, Sanger GJ ( 2008 ) . Synergy between 5-HT4 receptor activation and acetylcholinesterase inhibition in human colon and rat forestomach . Neurogastroenterol Motil vol. 20 , 539 - 545 .
Heightman TD, Scott JS, Longley M, Bordas V, Dean DK, Elliott R, Hutley G, Witherington J et al. ( 2007 ) . Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification . Bioorganic and Medicinal Chemistry Letters vol. 17 , ( 23 ) 6584 - 6587 .
Sanger GJ ( 2007 ) . Endocannabinoids and the gastrointestinal tract: What are the key questions? . British Journal of Pharmacology vol. 152 , ( 5 ) 663 - 670 .
Sanger GJ ( 2007 ) . Gastrointestinal diseases . Drug Discovery Today: Therapeutic Strategies vol. 4 , ( 3 ) 153 - 154 .
Borman RA, Sanger GJ ( 2007 ) . Novel approaches and clinical opportunity for gastrointestinal prokinetic drugs . Drug Discovery Today: Therapeutic Strategies vol. 4 , ( 3 ) 165 - 170 .
Shafton AD, Bogeski G, Kitchener PD, Sanger GJ, Furness JB, Shimizu Y ( 2007 ) . Effects of NMDA receptor antagonists on visceromotor reflexes and on intestinal motility, in vivo . Neurogastroenterology and Motility vol. 19 , ( 7 ) 617 - 624 .
Jarvie EM, North Laidler VJ, Corcoran S, Bassil A, Sanger GJ ( 2007 ) . Differences between the abilities of tegaserod and motilin receptor agonists to stimulate gastric motility in vitro . British Journal of Pharmacology vol. 150 , ( 4 ) 455 - 462 .
Dass NB, Bassil AK, North-Laidler VJ, Morrow R, Aziz E, Tuladhar BR, Sanger GJ ( 2007 ) . Neuromedin U can exert colon-specific, enteric nerve-mediated prokinetic activity, via a pathway involving NMU <inf>1</inf> receptor activation . British Journal of Pharmacology vol. 150 , ( 4 ) 502 - 508 .
Bassil AK, Häglund Y, Brown J, Rudholm T, Hellström PM, Näslund E, Lee K, Sanger GJ ( 2007 ) . Little or no ability of obestatin to interact with ghrelin or modify motility in the rat gastrointestinal tract . British Journal of Pharmacology vol. 150 , ( 1 ) 58 - 64 .
Malik NM, Liu YL, Cole N, Sanger GJ, Andrews PLR ( 2007 ) . Differential effects of dexamethasone, ondansetron and a tachykinin NK<inf>1</inf> receptor antagonist (GR205171) on cisplatin-induced changes in behaviour, food intake, pica and gastric function in rats . European Journal of Pharmacology vol. 555 , ( 2-3 ) 164 - 173 .
Cellek S, Thangiah R, Bassil AK, Campbell CA, Gray KM, Stretton JL, Lalude O, Vivekanandan S et al. ( 2007 ) . Demonstration of Functional Neuronal β<inf>3</inf>-Adrenoceptors Within the Enteric Nervous System . Gastroenterology vol. 133 , ( 1 ) 175 - 183 .
Sanger GJ, Tuladhar BR, Brown J, Aziz E, Sivakumar D, Furness JB ( 2007 ) . Modulation of peristalsis by NK3 receptor antagonism in guinea-pig isolated ileum is revealed as intraluminal pressure is raised . Autonom Autocoid Pharmacol vol. 27 , 105 - 111 .
Dass NB, John AK, Bassil AK, Crumbley CW, Shehee WR, Maurio FP, Moore GBT, Taylor CM et al. ( 2007 ) . The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation . Neurogastroenterology and Motility vol. 19 , ( 1 ) 66 - 74 .
Sanger GJ, Andrews PLR ( 2006 ) . Treatment of nausea and vomiting: Gaps in our knowledge . Autonomic Neuroscience: Basic and Clinical vol. 129 , ( 1-2 ) 3 - 16 .
Shimizu Y, Chang EC, Shafton AD, Ferens DM, Sanger GJ, Witherington J, Furness JB ( 2006 ) . Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat . Journal of Physiology vol. 576 , ( 1 ) 329 - 338 .
Cellek S, John AK, Thangiah R, Dass NB, Bassil AK, Jarvie EM, Lalude O, Vivekanandan S et al. ( 2006 ) . 5-HT<inf>4</inf> receptor agonists enhance both cholinergic and nitrergic activities in human isolated colon circular muscle . Neurogastroenterology and Motility vol. 18 , ( 9 ) 853 - 861 .
Liu YL, Malik NM, Sanger GJ, Andrews PLR ( 2006 ) . Ghrelin alleviates cancer chemotherapy-associated dyspepsia in rodents . Cancer Chemotherapy and Pharmacology vol. 58 , ( 3 ) 326 - 333 .
Bassil AK, Dass NB, Sanger GJ ( 2006 ) . The prokinetic-like activity of ghrelin in rat isolated stomach is mediated via cholinergic and tachykininergic motor neurones . European Journal of Pharmacology vol. 544 , ( 1-3 ) 146 - 152 .
Rudd JA, Ngan MP, Wai MK, King AG, Witherington J, Andrews PLR, Sanger GJ ( 2006 ) . Anti-emetic activity of ghrelin in ferrets exposed to the cytotoxic anti-cancer agent cisplatin . Neuroscience Letters vol. 392 , ( 1-2 ) 79 - 83 .
Malik NM, Moore GBT, Smith G, Liu YL, Sanger GJ, Andrews PLR ( 2006 ) . Behavioural and hypothalamic molecular effects of the anti-cancer agent cisplatin in the rat: A model of chemotherapy-related malaise? . Pharmacology Biochemistry and Behavior vol. 83 , ( 1 ) 9 - 20 .
Sanger GJ, Tuladhar BR, Bueno L, Furness JB ( 2006 ) . Defensive and pathological functions of the gastrointestinal NK3 receptor . Vascular Pharmacology vol. 45 , 215 - 220 .
Sanger GJ, Holzer P ( 2005 ) . Endogenous opioids and the gastrointestinal tract . Seminars in Colon and Rectal Surgery vol. 16 , ( 4 ) 197 - 199 .
Bassil AK, Dass NB, Murray CD, Muir A, Sanger GJ ( 2005 ) . Prokineticin-2, motilin, ghrelin and metoclopramide: Prokinetic utility in mouse stomach and colon . European Journal of Pharmacology vol. 524 , ( 1-3 ) 138 - 144 .
Liu YL, Malik N, Sanger GJ, Friedman MI, Andrews PLR ( 2005 ) . Pica - A model of nausea? Species differences in response to cisplatin . Physiology and Behavior vol. 85 , ( 3 ) 271 - 277 .
King AG, Sanger GJ ( 2005 ) . Effect of a selective and potent central nervous system penetrant, neurokinin-3 receptor antagonist (SB-222200), on cisplatin-induced emesis in the ferret . Neuroscience Letters vol. 376 , ( 1 ) 5 - 8 .
Sanger GJ, Tuladhar BR ( 2004 ) . The role of endogenous opioids in the control of gastrointestinal motility: Predictions from in vitro modelling . Neurogastroenterology and Motility vol. 16 , ( SUPPL. 2 ) 38 - 45 .
O'Connor V, Genin A, Davis S, Karishma KK, Doyère V, De Zeeuw CI, Sanger G, Hunt SP et al. ( 2004 ) . Differential Amplification of Intron-containing Transcripts Reveals Long Term Potentiation-associated Up-regulation of Specific Pde10A Phosphodiesterase Splice Variants . Journal of Biological Chemistry vol. 279 , ( 16 ) 15841 - 15849 .
Shafton AD, Bogeski G, Kitchener PD, Lewis VA, Sanger GJ, Furness JB ( 2004 ) . Effects of the peripherally acting NK<inf>3</inf> receptor antagonist, SB-235375, on intestinal and somatic nociceptive responses and on intestinal motility in anaesthetized rats . Neurogastroenterology and Motility vol. 16 , ( 2 ) 223 - 231 .
Sanger GJ ( 2004 ) . Neurokinin NK <inf>1</inf> and NK <inf>3</inf> receptors as targets for drugs to treat gastrointestinal motility disorders and pain . British Journal of Pharmacology vol. 141 , ( 8 ) 1303 - 1312 .
Dass NB, Hill J, Muir A, Testa T, Wise A, Sanger GJ ( 2003 ) . The rabbit motilin receptor: Molecular characterisation and pharmacology . British Journal of Pharmacology vol. 140 , ( 5 ) 948 - 954 .
Read KE, Sanger GJ, Ramage AG ( 2003 ) . Evidence for the involvement of central 5-HT <inf>7</inf> receptors in the micturition reflex in anaesthetized female rats . British Journal of Pharmacology vol. 140 , ( 1 ) 53 - 60 .
Dass NB, Munonyara M, Bassil AK, Hervieu GJ, Osbourne S, Corcoran S, Morgan M, Sanger GJ ( 2003 ) . Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin . Neuroscience vol. 120 , ( 2 ) 443 - 453 .
Bogeski G, Lean NP, Kitchener PD, Timar-Peregrin A, Sanger GJ, Shafton AD, Furness JB ( 2003 ) . Analysis of factors that determine the compliance of rat jejunum to distension in vivo . Neurogastroenterology and Motility vol. 15 , ( 4 ) 417 - 425 .
Fioramonti J, Gaultier E, Toulouse M, Sanger GJ, Bueno L ( 2003 ) . Intestinal anti-nociceptive behaviour of NK<inf>3</inf> receptor antagonism in conscious rats: Evidence to support a peripheral mechanism of action . Neurogastroenterology and Motility vol. 15 , ( 4 ) 363 - 369 .
Hoyle CHV, Hill J, Sanger GJ, Andrews PLR ( 2003 ) . Analysis of pancreatic polypeptide cDNA from the house musk shrew, Suncus murinus, suggests a phylogenetically closer relationship with humans than for other small laboratory animal species . Regulatory Peptides vol. 114 , ( 2-3 ) 137 - 144 .
Génin A, French P, Doyère V, Davis S, Errington ML, Maroun M, Stean T, Truchet B et al. ( 2003 ) . LTP but not seizure is associated with up-regulation of AKAP-150 . European Journal of Neuroscience vol. 17 , ( 2 ) 331 - 340 .
Newton RA, Case CP, Lawson SN, Bingham S, Davey P, Medhurst AD, Piercy V, Raval P et al. ( 2003 ) . Molecular approaches to the study of pain . Pain: Current Understanding, Emerging Therapies, and Novel Approaches to Drug Discovery ,
Andrews PLR, Sanger GJ ( 2002 ) . Abdominal vagal afferent neurones: An important target for the treatment ofgastrointestinal dysfunction . Current Opinion in Pharmacology vol. 2 , ( 6 ) 650 - 656 .
Sanger GJ, Hicks GA ( 2002 ) . Drugs targeting functional bowel disorders: Insights from animal studies . Current Opinion in Pharmacology vol. 2 , ( 6 ) 678 - 683 .
Furness JB, Sanger GJ ( 2002 ) . Gastrointestinal neuropharmacology: Identification of therapeutic targets . Current Opinion in Pharmacology vol. 2 , ( 6 ) 609 - 611 .
Furness JB, Sanger GJ ( 2002 ) . Intrinsic nerve circuits of the gastrointestinal tract: Identification of drug targets . Current Opinion in Pharmacology vol. 2 , ( 6 ) 612 - 622 .
Sanger GJ, Munonyara ML, Dass N, Prosser H, Pangalos MN, Parsons ME ( 2002 ) . GABA<inf>B</inf> receptor function in the ileum and urinary bladder of wildtype and GABA<inf>B1</inf> subunit null mice . Autonomic and Autacoid Pharmacology vol. 22 , ( 3 ) 147 - 154 .
Timar-Peregrin A, Kumano K, Khalil Z, Sanger GJ, Furness JB ( 2001 ) . The relationship between propagated contractions and pseudoaffective changes in blood pressure in response to intestinal distension . Neurogastroenterology and Motility vol. 13 , ( 6 ) 575 - 584 .
Newton RA, Bingham S, Case PC, Sanger GJ, Lawson SN ( 2001 ) . Dorsal root ganglion neurons show increased expression of the calcium channel α2δ-1 subunit following partial sciatic nerve injury . Molecular Brain Research vol. 95 , ( 1-2 ) 1 - 8 .
Fedouloff M, Hossner F, Voyle M, Ranson J, Powles J, Riley G, Sanger G ( 2001 ) . Synthesis and pharmacological activity of metabolites of the 5-HT<inf>4</inf> receptor antagonist SB-207266 . Bioorganic and Medicinal Chemistry vol. 9 , ( 8 ) 2119 - 2128 .
Medhurst AD, Lezoualc'h F, Fischmeister R, Middlemiss DN, Sanger, GJ ( 2001 ) . Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT<inf>4</inf> receptor in the central nervous system by TaqMan real time RT-PCR . Molecular Brain Research vol. 90 , ( 2 ) 125 - 134 .
Rausch O, Newton RA, Bingham S, Macdonald R, Case CP, Sanger GJ, Lawson SN, Reith AD ( 2000 ) . Nerve injury-associated kinase: A sterile 20-like protein kinase up-regulated in dorsal root ganglia in a rat model of neuropathic pain . Neuroscience vol. 101 , ( 3 ) 767 - 777 .
Hayes P, Meadows HJ, Gunthorpe MJ, Harries MH, Duckworth DM, Cairns W, Harrison DC, Clarke CE et al. ( 2000 ) . Cloning and functional expression of a human orthologue of rat vanilloid receptor-1 . Pain vol. 88 , ( 2 ) 205 - 215 .
Sanger GJ, Ellis ES, Harries MH, Tilford NS, Wardle KA, Benham CD ( 2000 ) . Rank-order inhibition by ω-conotoxins in human and animal autonomic nerve preparations . European Journal of Pharmacology vol. 388 , ( 1 ) 89 - 95 .
Sanger GJ, Yoshida M, Yahyah M, Kitazumi K ( 2000 ) . Increased defecation during stress or after 5-hydroxytryptophan: Selective inhibition by the 5-HT<inf>4</inf> receptor antagonist, SB-207266 . British Journal of Pharmacology vol. 130 , ( 3 ) 706 - 712 .
Newton RA, Bingham S, Davey PD, Medhurst AD, Piercy V, Raval P, Parsons AA, Sanger GJ et al. ( 1999 ) . Identification of differentially expressed genes in dorsal root ganglia following partial sciatic nerve injury . Neuroscience vol. 95 , ( 4 ) 1111 - 1120 .
Wood MD, Murkitt KL, Gager T, Ranson J, Sanger GJ ( 1999 ) . Pharmacological characterisation of the human P2X<inf>4</inf> receptor using the FLIPR . Pharmacology Reviews and Communications vol. 10 , ( 4 ) 341 - 347 .
Sanger GJ ( 1999 ) . Hypersensitivity and hyperreactivity in the irritable bowel syndrome: An opportunity for drug discovery . Digestive Diseases vol. 17 , ( 2 ) 90 - 99 .
Carpenter D, Meadows HJ, Brough S, Chapman G, Clarke C, Coldwell M, Davis R, Harrison D et al. ( 1999 ) . Site-specific splice variation of the human P2X<inf>4</inf> receptor . Neuroscience Letters vol. 273 , ( 3 ) 183 - 186 .
Smith MI, Banner SE, Sanger GJ ( 1999 ) . 5-HT<inf>4</inf> receptor antagonism potentiates inhibition of intestinal allodynia by 5-HT<inf>3</inf> receptor antagonism in conscious rats . Neuroscience Letters vol. 271 , ( 1 ) 61 - 64 .
Piercy V, Banner SE, Bhattacharyya A, Parsons AA, Sanger GJ, Smith SA, Bingham S ( 1999 ) . Thermal, but not mechanical, nociceptive behavior is altered in the Zucker diabetic fatty rat and is independent of glycemic status . Journal of Diabetes and its Complications vol. 13 , ( 3 ) 163 - 169 .
Reavill C, Hatcher JP, Lewis VA, Sanger GJ, Hagan J ( 1998 ) . 5-HT<inf>4</inf> receptor antagonism does not affect motor and reward 4 mechanisms in the rat . European Journal of Pharmacology vol. 357 , ( 2-3 ) 115 - 120 .
Sanger GJ, Banner SE, Smith MI, Wardle KA ( 1998 ) . SB-207266: 5-HT<inf>4</inf> receptor antagonism in human isolated gut and prevention of 5-HT-evoked sensitization of peristalsis and increased defaecation in animal models . Neurogastroenterology and Motility vol. 10 , ( 4 ) 271 - 279 .
King FD, Gaster LM, Sanger GJ, Wardle KA ( 1998 ) . Modulators of 5-HT functions in the treatment of gastrointestinal disorders . Pharmacochemistry Library , vol. 29 ,
Wardle KA, Ranson J, Sanger GJ ( 1997 ) . Pharmacological characterization of the vanilloid receptor in the rat dorsal spinal cord . British Journal of Pharmacology vol. 121 , ( 5 ) 1012 - 1016 .
Kennett GA, Bright F, Trail B, Blackburn TP, Sanger GJ ( 1997 ) . Anxiolytic-like actions of the selective 5-HT<inf>4</inf> receptor antagonists SB 204070A and SB 207266A in rats . Neuropharmacology vol. 36 , ( 4-5 ) 707 - 712 .
Banner SE, Smith MI, Bywater D, Gaster LM, Sanger GJ ( 1996 ) . Increased defaecation caused by 5-HT<inf>4</inf> receptor activation in the mouse . European Journal of Pharmacology vol. 308 , ( 2 ) 181 - 186 .
Sanger GJ ( 1996 ) . 5-Hydroxytryptamine and functional bowel disorders . Neurogastroenterology and Motility vol. 8 , ( 4 ) 319 - 331 .
Wardle KA, Furey G, Sanger GJ ( 1996 ) . Pharmacological characterization of the vanilloid receptor in the rat isolated vas deferens . Journal of Pharmacy and Pharmacology vol. 48 , ( 3 ) 285 - 291 .
Wardle KA, Bingham S, Ellis ES, Gaster LM, Rushant B, Smith MI, Sanger GJ ( 1996 ) . Selective and functional 5-hydroxytryptamine<inf>4</inf> receptor antagonism by SB 207266 . British Journal of Pharmacology vol. 118 , ( 3 ) 665 - 670 .
Gaster LM, Joiner GF, King FD, Wyman PA, Sutton JM, Bingham S, Ellis ES, Sanger GJ et al. ( 1995 ) . N-[(1-Butyl-4-piperidinyl)methyl]-3,4-dihydro-2ff-[1,3] oxazino [3,2-α] indole-10-carboxamide Hydrochloride: The First Potent and Selective 5-HT<inf>4</inf> Receptor Antagonist Amide with Oral Activity . Journal of Medicinal Chemistry vol. 38 , ( 24 ) 4760 - 4763 .
Banner SE, Carter M, Sanger GJ ( 1995 ) . 5-Hydroxytryptamine<inf>3</inf> receptor antagonism modulates a noxious visceral pseudoaffective reflex . Neuropharmacology vol. 34 , ( 3 ) 263 - 267 .
BINGHAM S, KING BF, RUSHANT B, SMITH MI, GASTER L, SANGER GJ ( 1995 ) . Antagonism by SB 204070 of 5‐HT‐evoked Contractions in the Dog Stomach: an In‐vivo Model of 5‐HT<inf>4</inf> Receptor Function . Journal of Pharmacy and Pharmacology vol. 47 , ( 3 ) 219 - 222 .
Banner SE, Sanger GJ ( 1995 ) . Differences between 5‐HT<inf>3</inf> receptor antagonists in modulation of visceral hypersensitivity . British Journal of Pharmacology vol. 114 , ( 2 ) 558 - 562 .
FRANKS CM, HARDCASTLE J, HARDCASTLE PT, SANGER GJ ( 1995 ) . Do 5‐HT<inf>4</inf> Receptors Mediate the Intestinal Secretory Response to 5‐HT in Rat In‐vivo? . Journal of Pharmacy and Pharmacology vol. 47 , ( 3 ) 213 - 218 .
Sanger GJ, Gaster LM ( 1994 ) . Overview central &amp; peripheral nervous system: 5-HT<inf>4</inf> receptor antagonists . Expert Opinion on Therapeutic Patents vol. 4 , ( 4 ) 323 - 332 .
Sanger GJ, Gaster LM ( 1994 ) . 5-HT<inf>4</inf> receptor antagonists . Expert Opinion on Therapeutic Patents vol. 4 , ( 4 ) 323 - 334 .
SANGER GJ, WARDLE KA ( 1994 ) . Constipation Evoked by 5‐HT<inf>3</inf>‐Receptor Antagonism: Evidence for Heterogeneous Efficacy among Different Antagonists in Guinea‐pigs . Journal of Pharmacy and Pharmacology vol. 46 , ( 8 ) 666 - 670 .
Bingham S, Blower PR, Davey PT, King PD, Sanger GJ, Wardle KA, Nishioka Y ( 1994 ) . Differences between the anti-emetic efficacies of the 5-HT<inf>3</inf> receptor antagonists granisetron and azasetron in the conscious ferret . Pharmacometrics vol. 47 , ( 1 ) 21 - 28 .
BERMUDEZ J, SANGER GJ ( 1994 ) . Prolonged anti‐emetic activity and 5‐HT<inf>3</inf>‐receptor antagonism by BRL 46470 in conscious ferrets . Journal of Pharmacy and Pharmacology vol. 46 , ( 6 ) 520 - 521 .
Gaster LM, Sanger GJ ( 1994 ) . SB 204070: 5-HT<inf>4</inf> receptor antagonists and their potential therapeutic utility . Drugs of the Future vol. 19 , ( 12 ) 1109 - 1121 .
Wardle KA, Ellis ES, Baxter GS, Kennett GA, Gaster LM, Sanger GJ ( 1994 ) . The effects of SB 204070, a highly potent and selective 5‐HT<inf>4</inf> receptor antagonist, on guinea‐pig distal colon . British Journal of Pharmacology vol. 112 , ( 3 ) 789 - 794 .
Blackburn TP, Baxter GS, Kennett GA, King FD, Piper DC, Sanger GJ, Thomas DR, Upton N et al. ( 1993 ) . BRL 46470A: a highly potent, selective and long acting 5-HT<inf>3</inf> receptor antagonist with anxiolytic-like properties . Psychopharmacology vol. 110 , ( 3 ) 257 - 264 .
Gaster LM, Jennings AJ, Joiner GF, King FD, Mulholland KR, Rahman SK, Starr S, Wyman PA et al. ( 1993 ) . (1-Butyl-4-piperidinyl)methyl 8-Amino-7-chloro-1,4-benzodioxane-5-carboxylate Hydrochloride: A Highly Potent and Selective 5-HT<inf>4</inf> Receptor Antagonist Derived from Metoclopramide . Journal of Medicinal Chemistry vol. 36 , ( 25 ) 4121 - 4123 .
King FD, Hadley MS, Joiner KT, Martin RT, Sanger GJ, Smith DM, Smith GE, Smith P et al. ( 1993 ) . Substituted Benzamides with Conformationally Restricted Side Chains. 5. Azahicyclo[x.y.z] Derivatives as 5-HT<inf>4</inf> Receptor Agonists and Gastric Motility Stimulants . Journal of Medicinal Chemistry vol. 36 , ( 6 ) 683 - 689 .
Wardle KA, Sanger GJ ( 1993 ) . The guinea‐pig distal colon ‐ a sensitive preparation for the investigation of 5‐HT<inf>4</inf> receptor‐mediated contractions . British Journal of Pharmacology vol. 110 , ( 4 ) 1593 - 1599 .
Bermudez J, King FD, Sanger GJ ( 1992 ) . Indazole and indoline as aromatic bioisosteres in the imidazole class of serotonin 5-HT<inf>3</inf> receptor antagonists . Bioorganic and Medicinal Chemistry Letters vol. 2 , ( 12 ) 1509 - 1512 .
BENNETT A, STAMFORD IF, SANGER GJ, BLOOM SR ( 1992 ) . The Effects of Various Peptides on Human Isolated Gut Muscle . Journal of Pharmacy and Pharmacology vol. 44 , ( 12 ) 960 - 967 .
Bermudez J, Fake CS, Joiner GF, Joiner KA, King FD, Miner WD, Sanger GJ ( 1990 ) . 5-Hydroxytryptamine (5-HT3) Receptor Antagonists. 1. Indazole and Indolizine-3-carboxylic Acid Derivatives . Journal of Medicinal Chemistry vol. 33 , ( 7 ) 1924 - 1929 .
King FD, Dabbs S, Bermudez J, Sanger GJ ( 1990 ) . Benzotriazinones as “Virtual Ring” Mimics of o-Methoxybenzamides: Novel and Potent 5-HT<inf>3</inf> Receptor Antagonists . Journal of Medicinal Chemistry vol. 33 , ( 11 ) 2942 - 2944 .
Sanger GJ ( 1990 ) . New antiemetic drugs . Canadian Journal of Physiology and Pharmacology . vol. 68 , 314 - 324 .
Bermudez J, Dunbar A, Sanger GJ, Turner DH ( 1990 ) . Stimulation of Canine Gastric Motility by BRL 24924, a New Gastric Prokinetic Agent . Neurogastroenterology &amp; Motility vol. 2 , ( 4 ) 281 - 286 .
Bermudez J, Dunbar A, Sanger GJ, Turner DH ( 1990 ) . Stimulation of canine gastric motility by BRL 24924, a new gastric prokinetic agent . Journal of Gastrointestinal Motility vol. 2 , ( 4 ) 281 - 286 .
Moss HE, Sanger GJ ( 1990 ) . The effects of granisetron, ICS 205-930 and ondansetron on the visceral pain reflex induced by duodenal distension . British Journal of Pharmacology vol. 100 , ( 3 ) 497 - 501 .
Sanger GJ, Nelson DR ( 1989 ) . Selective and functional 5-hydroxytryptamine<inf>3</inf> receptor antagonism by BRL 43694 (granisetron) . European Journal of Pharmacology vol. 159 , ( 2 ) 113 - 124 .
King FD, Sanger GJ ( 1989 ) . 5-HT<inf>3</inf> receptor antagonists . Drugs of the Future vol. 14 , ( 9 ) 875 - 889 .
Wardle KA, Sanger GJ ( 1989 ) . Atypical 5-HT receptors in guinea-pig isolated ileum . British journal of pharmacology vol. 98 Suppl ,
Sanger GJ, King FD ( 1988 ) . From metoclopramide to selective gut motility stimulants and 5-HT<inf>3</inf> receptor antagonists . Drug Design and Delivery vol. 3 , ( 4 ) 273 - 295 .
King FD, Sanger GJ ( 1988 ) . Gastrointestinal Motility Enhancing Agents . Annual Reports in Medicinal Chemistry vol. 23 , ( C ) 201 - 210 .
Andrews PLR, Rapeport WG, Sanger GJ ( 1988 ) . Neuropharmacology of emesis induced by anti-cancer therapy . Trends in Pharmacological Sciences vol. 9 , ( 9 ) 334 - 341 .
Burke T, Sanger G ( 1988 ) . Regionally selective cholinergic stimulation by BRL 24924 in the human isolated gut . British Journal of Clinical Pharmacology vol. 26 , ( 3 ) 261 - 265 .
Bermudez J, Boyle EA, Miner WD, Sanger GJ ( 1988 ) . The anti-emetic potential of the 5-hydroxytryptamine3 receptor antagonist BRL 43694 . British Journal of Cancer vol. 58 , ( 5 ) 644 - 650 .
Sanger GJ ( 1987 ) . Activation of a myenteric 5‐hydroxytryptamine‐like receptor by metoclopramide . Journal of Pharmacy and Pharmacology vol. 39 , ( 6 ) 449 - 453 .
SANGER GJ ( 1987 ) . Evidence that 5-hydroxytryptamine3 receptors mediate cytotoxic drug and radiation-evoked emesis . British Journal of Cancer vol. 56 , 159 - 162 .
Sanger GJ ( 1987 ) . Increased gut cholinergic activity and antagonism of 5‐hydroxytryptamine M‐receptors by BRL 24924: potential clinical importance of BRL 24924 . British Journal of Pharmacology vol. 91 , ( 1 ) 77 - 87 .
Sanger GJ, McClelland CM ( 1986 ) . Increased gastric cholinergic activity evoked by 5-hydroxy-L-tryptophan in the rat . European Journal of Pharmacology vol. 127 , ( 3 ) 179 - 185 .
SANGER GJ, Miner WD ( 1986 ) . Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism . British Journal of Pharmacology vol. 88 , 497 - 499 .
Sanger GJ ( 1985 ) . The effects of various pharmacological agents on the metoclopramide-induced increase in cholinergic-mediated contractions of rat isolated forestomach . European Journal of Pharmacology vol. 114 , ( 2 ) 139 - 145 .
Sanger GJ ( 1985 ) . Effects of metoclopramide and domperidone on cholinergically mediated contractions of human isolated stomach muscle . Journal of Pharmacy and Pharmacology vol. 37 , ( 9 ) 661 - 664 .
Sanger GJ ( 1985 ) . Three different ways in which 5‐hydroxytryptamine can affect cholinergic activity in guinea‐pig isolated ileum . Journal of Pharmacy and Pharmacology vol. 37 , ( 8 ) 584 - 586 .
Bennett A, Sanger GJ, Stamford IF, Hensby CN ( 1983 ) . Prostanoids formed by human gastrointestinal tissues and their effects on muscle activity . Advances in prostaglandin, thromboxane, and leukotriene research vol. 12 , 379 - 381 .
Sanger GJ, Jackson A, Bennett A ( 1982 ) . A prostaglandin analogue which potently relaxes human uterus but not gut muscle . European Journal of Pharmacology vol. 81 , ( 1 ) 141 - 143 .
BENNETT A, SANGER GJ ( 1982 ) . PINANE THROMBOXANE A<inf>2</inf> ANALOGUES ARE NON‐SELECTIVE PROSTANOID ANTAGONISTS IN RAT AND HUMAN STOMACH MUSCLE . British Journal of Pharmacology vol. 77 , ( 4 ) 591 - 596 .
Sanger GJ, Hensby CN, Stamford IF, Bennett A ( 1981 ) . Identification of arachidonic acid metabolites extracted from human uterus, and their effects on the isolated myometrium . Journal of Pharmacy and Pharmacology vol. 33 , ( 1 ) 607 - 610 .
BENNETT A, HENSBY CN, SANGER GJ, STAMFORD IF ( 1981 ) . METABOLITES OF ARACHIDONIC ACID FORMED BY HUMAN GASTROINTESTINAL TISSUES AND THEIR ACTIONS ON THE MUSCLE LAYERS . British Journal of Pharmacology vol. 74 , ( 2 ) 435 - 444 .
SANGER GJ, BENNETT A ( 1981 ) . Secoverine hydrochloride is a muscarinic antagonist in human isolated gastrointestinal muscle and myometrium . Journal of Pharmacy and Pharmacology vol. 33 , ( 1 ) 711 - 714 .
BENNETT A, PRATT D, SANGER GJ ( 1980 ) . ANTAGONISM BY FENAMATES OF PROSTAGLANDIN ACTION IN GUINEA‐PIG AND HUMAN ALIMENTARY MUSCLE . British Journal of Pharmacology vol. 68 , ( 3 ) 357 - 362 .
BENNETT A, JAROSIK C, SANGER GJ, WILSON DE ( 1980 ) . ANTAGONISM OF PROSTANOID‐INDUCED CONTRACTIONS OF RAT GASTRIC FUNDUS MUSCLE BY SC‐19220, SODIUM MECLOFENAMATE, INDOMETHACIN OR TRIMETHOQUINOL . British Journal of Pharmacology vol. 71 , ( 1 ) 169 - 175 .
Lacey SM, Sanger GJ ( 1980 ) . Antagonism of prostanoid-induced contractions of rat stomach muscle by trimethoquinol or isoxsuprine . British Journal of Pharmacology vol. 70 , ( 1 )
Sanger GJ, Bennett A ( 1980 ) . PGI2 or PGE2 selectively antagonize responses to excitatory PGs in human isolated myometrium . Advances in prostaglandin and thromboxane research vol. 6 , 399 - 400 .
Bennett A, Sanger GJ ( 1980 ) . Prostacyclin relaxes the longitudinal muscle of human isolated stomach and antagonizes contractions to some prostanoids . Journal of Physiology vol. VOL 298 ,
SANGER GJ, BENNETT A ( 1980 ) . Regional differences in the responses to prostanoids of circular muscle from guinea‐pig isolated intestine . Journal of Pharmacy and Pharmacology vol. 32 , ( 1 ) 705 - 708 .
SANGER GJ, WATT AJ ( 1980 ) . Some mechanisms which may modulate noradrenaline release in guinea‐pig isolated ileum . Journal of Pharmacy and Pharmacology vol. 32 , ( 1 ) 188 - 191 .
Sanger GJ, Bennett A ( 1980 ) . Trimethoquinol selectively antagonizes contractions of rat gastric fundus to TXB2 and epoxymethano analogs of PGH2 . Advances in prostaglandin and thromboxane research vol. 8 , 1559 - 1560 .
Bennett A, Sanger GJ ( 1979 ) . Prostacyclin and prostaglandin E<inf>2</inf> selectively antagonize responses of human isolated myometrium to excitatory prostaglandins . Journal of Physiology vol. Vol. 292 ,
Bennett A, Carroll MA, Sanger GJ ( 1979 ) . Sodium flufenamate antagonises the potentiation by prostaglandins of noradrenaline-induced vasoconstriction in rat mesentery . British Journal of Pharmacology vol. 66 , ( 3 )
Bennett A, Sanger GJ ( 1979 ) . Trimethoquinol selectively antagonises longitudinal muscle contractions of rat isolated gastric fundus to thromboxane B<inf>2</inf> and epoxymethano analogues of PGH<inf>2</inf> . British Journal of Pharmacology vol. 66 , ( 3 )
SANGER GJ, WATT AJ ( 1978 ) . The effect of PGE<inf>1</inf> on peristalsis and on perivascular nerve inhibition of peristaltic activity in guinea‐pig isolated ileum . Journal of Pharmacy and Pharmacology vol. 30 , ( 1 ) 762 - 765 .
Bennett A, Sanger GJ ( 1978 ) . The effects of prostaglandin D<inf>2</inf> on the circular muscle of guinea-pig isolated ileum and colon . British Journal of Pharmacology vol. 63 , ( 2 )
Sanger GJ, Watt AJ ( 1976 ) . A postsynaptic action of prostaglandin E<inf>1</inf> on sympathetic responses in guinea pig ileum . British Journal of Pharmacology vol. 58 , ( 2 )
Blair EL, Grund ER, Reed JD, Sanders DJ, Sanger G, Shaw B ( 1975 ) . The effect of sympathetic nerve stimulation on serum gastrin, gastric acid secretion and mucosal blood flow responses to meat extract stimulation in anaesthetized cats . The Journal of Physiology vol. 253 , ( 2 ) 493 - 504 .