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Research

Publications: Dr James Whiteford

Belvedere R, Morretta E, Pessolano E, Novizio N, Tosco A, Porta A, Whiteford J, Perretti M et al. ( 2021 ) . Mesoglycan exerts its fibrinolytic effect through the activation of annexin A2 . Journal of Cellular Physiology vol. 236 , ( 7 ) 4926 - 4943 .
Eldridge S, Barawi A, Wang H, Roelofs A, Kaneva M, Guan Z, Lydon H, Thomas B et al. ( 2021 ) . AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 1052.1 - 101052 .
Thorup AS, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J et al. ( 2021 ) . OP0200 BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 120.1 - 12121 .
Tsoyi K, Liang X, De Rossi G, Ryter SW, Xiong K, Chu SG, Liu X, Ith B et al. ( 2021 ) . CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis . American Journal of Respiratory and Critical Care Medicine
Gopal S, Arokiasamy S, Pataki C, Whiteford JR, Couchman JR ( 2021 ) . Syndecan receptors: Pericellular regulators in development and inflammatory disease . Open Biology vol. 11 , ( 2 )
Pessolano E, Belvedere R, Novizio N, Filippelli A, Perretti M, Whiteford J, Petrella A ( 2021 ) . Mesoglycan connects Syndecan-4 and VEGFR2 through Annexin A1 and formyl peptide receptors to promote angiogenesis in vitro . FEBS Journal
De Rossi G, Vähätupa M, Cristante E, Arokiasamy S, Liyanage SE, May U, Pellinen L, Uusitalo-Järvinen H et al. ( 2021 ) . Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA-Induced VE-Cadherin Internalization . Arteriosclerosis, Thrombosis, and Vascular Biology1374 - 1389 .
Thorup A-S, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J et al. ( 2020 ) . ROR2 blockade as a therapy for osteoarthritis . Science Translational Medicine vol. 12 , ( 561 )
Eldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, GUAN Z, Lydon H, Thomas B et al. ( 2020 ) . Agrin induces long term osteochondral regeneration by supporting repair morphogenesis . Science Translational Medicine vol. 12 , ( 559 )
Arokiasamy S, De Rossi G, Whiteford JR ( 2020 ) . Identification of a novel therapeutic peptide from Syndecan-3 . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 101 , A2 - A2 .
Balderstone M, Arokiasamy S, De Rossi G, Whiteford JR ( 2020 ) . Targeting a disease "off switch" . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 101 , A2 - A2 .
Godmann L, Bollmann M, Korb-Pap A, König U, Sherwood J, Beckmann D, Mühlenberg K, Echtermeyer F et al. ( 2020 ) . Antibody-mediated inhibition of syndecan-4 dimerisation reduces interleukin (IL)-1 receptor trafficking and signalling . Annals of the Rheumatic Diseases vol. 79 , ( 4 ) 481 - 489 .
Arokiasamy S, Balderstone MJM, De Rossi G, Whiteford JR ( 2020 ) . Syndecan-3 in Inflammation and Angiogenesis . Frontiers in Immunology vol. 10 ,
De Rossi G, Vahatupa M, Cristante E, Liyanage SE, May U, Uusitalo-Jarvinen H, Bainbridge JW, Jarvinen TAH et al. ( 2019 ) . A novel role for Syndecan-4 in neovascular eye diseases . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 100 , A38 - A38 .
Whiteford JR, Arokiasamy S, De Rossi G ( 2019 ) . Translating the matrix . British Journal of Pharmacology vol. 176 , ( 1 ) 3 - 4 .
Vahatupa M, De Rossi G, Jarvinen TAH, Uusitalo-Jarvinen H, Whiteford JR ( 2018 ) . Sdc4 deficiency leads to reduced VEGFA induced pathological ocular angiogenesis . INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . vol. 59 ,
Eldridge SE, Thomas BL, Shanmuganathan K, Strachan D, Ali A, Thorup A-S, Caxaria S, Nalesso G et al. ( 2017 ) . Agrin inhibits canonical WNT signalling through LRP4 . Osteoarthritis and Cartilage . vol. 25 ,
De Rossi G, Cristante E, Bland E, Bainbridge JW, Whiteford JR ( 2017 ) . A syndecan-derived peptide for the treatment of Wet age-related macular degeneration . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 98 , A15 - A15 .
De Rossi G, Cristante E, Vahatupa M, Liyanage SE, May U, Pellinen L, Uusitalo-Jarvinen H, Bainbridge JW et al. ( 2017 ) . VEGFA-driven pathological angiogenesis requires the proteoglycan syndecan-4 . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 98 , A14 - A15 .
Rauzi F, Kirkby NS, Edin ML, Whiteford J, Zeldin DC, Mitchell JA, Warner TD ( 2016 ) . Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1 . The FASEB Journal
WHITEFORD J, Ma B, Woodfin, Nourshargh ( 2016 ) . Underlying chronic inflammation alters the profile and mechanisms of acute neutrophil recruitment . Journal of Pathology
Reglerol N, Beall R, Cabrera C, Pickworthl C, Golding M, Whiteford J, Nightingale T, Imhof B et al. ( 2016 ) . JAM-C deficiency primes endothelial cells for a pro-inflammatory state . FASEB JOURNAL . vol. 30 ,
Eldridge SE, Petrycki E, Pitzalis C, Whiteford J, Dell'Accio F ( 2016 ) . MMP3 cleaves agrin in cartilage and reduces its chondrogenic potency . Osteoarthritis and Cartilage . vol. 24 ,
Hawkins KE, Joy S, Delhove JMKM, Kotiadis VN, Fernandez E, Fitzpatrick LM, Whiteford JR, King PJ et al. ( 2016 ) . NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming . Cell Reports vol. 14 , ( 8 ) 1883 - 1891 .
Woodfin A, Beyrau M, Voisin MB, Ma B, Whiteford JR, Hordijk PL, Hogg N, Nourshargh S ( 2016 ) . ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia . Blood vol. 127 , ( 7 ) 898 - 907 .
Whiteford JR, De Rossi G, Woodfin A ( 2016 ) . Mutually Supportive Mechanisms of Inflammation and Vascular Remodeling . vol. 326 , 201 - 278 .
Madalli S, Beyrau M, Whiteford J, Duchene J, Nandhra IS, Patel NSA, Motwani MP, Gilroy DW et al. ( 2015 ) . Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states . Biology of Sex Differences vol. 6 , ( 1 )
Kay E, Gomez-Garcia L, Woodfin A, Scotland RS, Whiteford JR ( 2015 ) . Sexual dimorphisms in leukocyte trafficking in a mouse peritonitis model . Journal of Leukocyte Biology vol. 98 , ( 5 ) 805 - 817 .
Gopinathan G, Milagre C, Pearce OMT, Reynolds L, Hodivala-Dilke K, Leinster A, Zhong H, Hollingsworth RE et al. ( 2015 ) . Abstract 4162: Interleukin–6 stimulates defective angiogenesis . 4162 - 4162 .
Gopinathan G, Milagre C, Pearce OMT, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE et al. ( 2015 ) . Interleukin-6 stimulates defective angiogenesis . Cancer Research vol. 75 , ( 15 ) 3098 - 3107 .
Rauzi F, Kirkby N, Edin M, Zeldin D, Whiteford J, Mitchell J, Warner T ( 2015 ) . 15(S)-HETE is a pro-angiogenic factor produced by platelets through COX-1 . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 13 , 225 - 225 .
Ma B, Whiteford JR, Nourshargh S, Woodfin A ( 2015 ) . Angiogenesis associated macrophages support elevated acute inflammatory responses . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION vol. 45 , 48 - 48 .
De Rossi G, Whiteford JR ( 2014 ) . Syndecans in angiogenesis and endothelial cell biology . Biochemical Society Transactions vol. 42 , ( 6 ) 1643 - 1646 .
De Rossi G, Evans AR, Kay E, Woodfin A, McKay TR, Nourshargh S, Whiteford JR ( 2014 ) . Shed syndecan-2 inhibits angiogenesis . Development vol. 141 , ( 22 ) e2207 - e2207 .
Kay E, Scotland RS, Whiteford JR ( 2014 ) . Sex-differences in classical monocyte recruitment during inflammation . CYTOKINE . vol. 70 , 50 - 50 .
De Rossi G, Evans AR, Kay E, Woodfin A, McKay TR, Nourshargh S, Whiteford JR ( 2014 ) . Shed syndecan-2 inhibits angiogenesis . J Cell Sci vol. 127 , ( Pt 21 ) 4788 - 4799 .
De Rossi G, Nourshargh S, Whiteford JR ( 2014 ) . Shed syndecan-2 is a regulator of angiogenesis . ANGIOGENESIS vol. 17 , ( 3 ) 756 - 756 .
De Rossi G, Nourshargh S, Whiteford JR ( 2014 ) . Syndecan-4 is required for VEGF-induced angiogenesis . ANGIOGENESIS vol. 17 , ( 3 ) 715 - 715 .
Kay E, Nourshargh S, Scotland RS, Whiteford JR ( 2014 ) . Sex-differences in classical monocyte recruitment during inflammation . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION vol. 44 , 14 - 15 .
Evans AR, De Rossi G, Woodfin A, Kay E, Leese AJ, Nourshargh S, Whiteford JR ( 2014 ) . The role of syndecan-4 in inflammation . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION vol. 44 , 23 - 23 .
Kay E, Scotland RS, Whiteford JR ( 2014 ) . Toll-like receptors: Role in inflammation and therapeutic potential . Biofactors vol. 40 , ( 3 ) 284 - 294 .
Halai K, Whiteford J, Ma B, Nourshargh S, Woodfin A ( 2014 ) . ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo . J Cell Sci vol. 127 , ( Pt 3 ) 620 - 629 .
Leinster DA, Colom B, Whiteford JR, Ennis DP, Lockley M, McNeish IA, Aurrand-Lions M, Chavakis T et al. ( 2013 ) . Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer . FASEB J vol. 27 , ( 10 ) 4244 - 4253 .
De Rossi G, Whiteford JR ( 2013 ) . Novel insight into the biological functions of syndecan ectodomain core proteins . Biofactors vol. 39 , ( 4 ) 374 - 382 .
De Rossi G, Scotland R, Whiteford J ( 2013 ) . Critical Factors in Measuring Angiogenesis Using the Aortic Ring Model . J Genet Syndr Gene Ther vol. 4 , ( 5 )
De Rossi G, Nourshargh S, Whiteford JR ( 2013 ) . Syndecan extracellular core proteins have anti-angiogenic properties . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 94 , A44 - A45 .
De Rossi G, Whiteford JR ( 2013 ) . A novel role for syndecan-3 in angiogenesis . F1000Res vol. 2 ,
WHITEFORD J, Xian X, Couchman JR ( 2012 ) . Syndecans as receptors for pericellular molecules . Extracellular Matrix: Pathobiology and Signaling , Editors: Karamanos, N , Walter de Gruyter
Proebstl D, Voisin MB, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D, Nourshargh S ( 2012 ) . Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo . J Exp Med vol. 209 , ( 6 ) 1219 - 1234 .
Whiteford JR, Xian X, Chaussade C, Vanhaesebroeck B, Nourshargh S, Couchman JR ( 2011 ) . Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148 . Molecular Biology of the Cell vol. 22 , ( 19 ) 3609 - 3624 .
Schaefer L, Evan L, Whiteford J, Dyer D, Rowan D ( 2011 ) . Cell signalling in inflammation . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 92 , A6 - A7 .
Whiteford JR, Xian X, Couchman JR ( 2011 ) . Syndecan-2 core protein directly interacts with the protein tyrosine phosphatase CD148/PTPRJ to promote integrin-mediated adhesion . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 92 , A13 - A14 .
Whiteford JR, Xian X, Couchman JR ( 2010 ) . Cell adhesion to the adhesion regulatory domains of syndecan-2 and-4 require the protein tyrosine receptor CD148/PTPRJ . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 91 , A26 - A26 .
Gopal S, Bober A, Whiteford JR, Multhaupt H, Yoneda A, Couchman JR ( 2010 ) . Heparan sulfate chain valency controls syndecan-4 function in cell adhesion . Journal of Biological Chemistry vol. 285 , 14247 - 14258 .
Multhaupt HAB, Yoneda A, Whiteford JR, Oh E-S, Lee W, Couchman JR ( 2009 ) . Syndecan signaling: when, where and why? . J Physiol Pharmacol vol. 60 Suppl 4 , 31 - 38 .
Okina E, Manon-Jensen T, Whiteford JR, Couchman JR ( 2009 ) . Syndecan proteoglycan contributions to cytoskeletal organization and contractility . Scand J Med Sci Sports vol. 19 , ( 4 ) 479 - 489 .
Whiteford JR, Ko S, Lee W, Couchman JR ( 2008 ) . Structural and cell adhesion properties of zebrafish syndecan-4 are shared with higher vertebrates . J Biol Chem vol. 283 , ( 43 ) 29322 - 29330 .
Lacroix H, Whiteford JR, Spanu PD ( 2008 ) . Localization of Cladosporium fulvum hydrophobins reveals a role for HCf-6 in adhesion . FEMS Microbiol Lett vol. 286 , ( 1 ) 136 - 144 .
Whiteford J, Couchman J ( 2008 ) . Integrin mediated cell adhesion to the syndecan‐4 ectodomain requires N‐glycosylation and phosphatases . The FASEB Journal . vol. 22 , 274 - 274 .
Alexopoulou AN, Couchman JR, Whiteford JR ( 2008 ) . The CMV early enhancer/chicken beta actin (CAG) promoter can be used to drive transgene expression during the differentiation of murine embryonic stem cells into vascular progenitors . BMC Cell Biology vol. 9 , ( 2 )
Whiteford JR, Behrends V, Kirby H, Kusche-Gullberg M, Muramatsu T, Couchman JR ( 2007 ) . Syndecans promote integrin-mediated adhesion of mesenchymal cells in two distinct pathways . Exp Cell Res vol. 313 , ( 18 ) 3902 - 3913 .
Whiteford JR, Couchman JR ( 2006 ) . A conserved NXIP motif is required for cell adhesion properties of the syndecan-4 ectodomain . J Biol Chem vol. 281 , ( 43 ) 32156 - 32163 .
Koo BK, Han I, Mortier E, Zimmermann P, Whiteford JR, Couchman JR, Oh ES, Lee W ( 2006 ) . Structural basis of cell adhesion signalling of syndecan-4 proteoglycan as a cell surface receptor . FEBS JOURNAL . vol. 273 , 90 - 90 .
Koo B-K, Jung YS, Shin J, Han I, Mortier E, Zimmermann P, Whiteford JR, Couchman JR et al. ( 2006 ) . Structural basis of syndecan-4 phosphorylation as a molecular switch to regulate signaling . J Mol Biol vol. 355 , ( 4 ) 651 - 663 .
Whiteford JR, Lacroix H, Talbot NJ, Spanu PD ( 2004 ) . Stage-specific cellular localisation of two hydrophobins during plant infection by the pathogenic fungus Cladosporium fulvum . Fungal Genet Biol vol. 41 , ( 6 ) 624 - 634 .
Johnson H, Whiteford JR, Eckert SE, Spanu PD ( 2003 ) . Production and secretion of Aspergillus nidulans catalase B in filamentous fungi driven by the promoter and signal peptide of the Cladosporium fulvum hydrophobin gene hcf-1 . Curr Genet vol. 44 , ( 3 ) 155 - 163 .
Whiteford JR, Spanu PD ( 2002 ) . Hydrophobins and the interactions between fungi and plants . Mol Plant Pathol vol. 3 , ( 5 ) 391 - 400 .
Whiteford JR, Spanu PD ( 2001 ) . The hydrophobin HCf-1 of Cladosporium fulvum is required for efficient water-mediated dispersal of conidia . Fungal Genet Biol vol. 32 , ( 3 ) 159 - 168 .
Whiteford JR, Wilson C, Tiwana H, Ebringer A ( 2000 ) . Genetic diversity in Proteus mirabilis isolates found in the urinary tract of rheumatoid arthritis patients . J INFECTION vol. 41 , ( 3 ) 245 - 248 .
Whiteford JR, Wood DA, Thurston CF ( 2000 ) . Characterisation of xylanases produced in liquid and compost cultures of the cultivated mushroom Agaricus bisporus . MYCOLOGICAL RESEARCH vol. 104 , 810 - 819 .
Whiteford JR, Thurston CF ( 2000 ) . The molecular genetics of cultivated mushrooms . Adv Microb Physiol vol. 42 , 1 - 23 .