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Research

Publications: Prof John Marshall

Murray ER, Brown NF, Howard P, Masterson L, Zammarchi F, van Berkel PH, Marshall JF ( 2021 ) . Effective targeting of pancreatic ductal adenocarcinoma metastases with an integrin av beta 6-targeting peptide-drug conjugate . CANCER RESEARCH . vol. 81 ,
Cutmore LC, Marshall JF ( 2021 ) . Current perspectives on the use of off the shelf car-t/nk cells for the treatment of cancer . Cancers vol. 13 , ( 8 )
Ohaida K, Allen M, Goom J, Marshall J, Jones L ( 2021 ) . Relationship between altered myoepithelial phenotype and the inflammatory cell infiltrate in progression of DCIS . BREAST . vol. 56 , S34 - S34 .
Raj D, Nikolaidi M, Garces I, Lorizio D, Castro NM, Caiafa SG, Moore K, Brown NF et al. ( 2021 ) . CEACAM7 is an effective target for CAR T-cell therapy of pancreatic ductal adenocarcinoma . Clinical Cancer Research vol. 27 , ( 5 ) 1538 - 1552 .
Langley RE, Gilbert DC, Duong T, Clarke NW, Nankivell M, Rosen SD, Mangar S, Macnair A et al. ( 2021 ) . Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme . The Lancet vol. 397 , ( 10274 ) 581 - 591 .
Meecham A, Marshall J ( 2021 ) . Harnessing the power of foot-and-mouth-disease virus for targeting integrin alpha-v beta-6 for the therapy of cancer . Expert Opinion on Drug Discovery vol. 16 , ( 7 ) 737 - 744 .
Dreyer SB, Upstill-Goddard R, Paulus-Hock V, Paris C, Lampraki EM, Dray E, Serrels B, Caligiuri G et al. ( 2021 ) . Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer . Gastroenterology vol. 160 , ( 1 ) 362 - 377.e13 .
Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A et al. ( 2021 ) . The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer . Nature Genetics vol. 53 , ( 1 ) 16 - 26 .
Bardhan A, Bruckner-Tuderman L, Chapple ILC, Fine JD, Harper N, Has C, Magin TM, Marinkovich MP et al. ( 2020 ) . Epidermolysis bullosa . Nature Reviews Disease Primers vol. 6 , ( 1 )
Raj D, Marshall J, Young TS, Aicher A, Heeschen C ( 2020 ) . Switchable CAR-T cells mediate long-term remission of PDAC . Pancreatology vol. 20 , ( 8 )
Meecham A, Marshall JF ( 2020 ) . The ITGB6 gene: its role in experimental and clinical biology . Gene: X vol. 5 ,
Meecham A, Marshall JF ( 2020 ) . The ITGB6 gene: its role in experimental and clinical biology . Gene vol. 763S ,
Cutmore L, Cornish D, Brown N, Nikolaidi M, Raj D, Heeschen C, Marshall J ( 2020 ) . VAR2CSA-based CAR-T cells for the treatment of pancreatic ductal adenocarcinoma . Pancreatology vol. 20 , ( 8 ) e6 - e7 .
Brown N, Nikolaidi M, Cutmore L, Cornish D, Raj D, Heeschen C, Marshall J ( 2020 ) . αvβ6 targeted CAR-T cells in immunocompetent orthotopic murine PDAC . Pancreatology vol. 20 , ( 8 )
Dexter K, BROWN N, Foster J, Kashani R, CHUPIN J, Cleaver J, Cutmore L, Marshall J et al. ( 2020 ) . Simultaneous dual isotope PET-SPECT/CT imaging of pancreatic cancer . Presented at: EMIM 2020 , Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob java.io.Serializable ,
Caley MP, Martins VL, Moore K, Lashari M, Nissinen L, Kähäri V-M, Alexander S, Jones E et al. ( 2020 ) . Loss of Laminin α3 induces cell invasion and macrophage infiltration in cutaneous squamous cell carcinoma . British Journal of Dermatology
Brunton H, Caligiuri G, Cunningham R, Upstill-Goddard R, Bailey UM, Garner IM, Nourse C, Dreyer S et al. ( 2020 ) . HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer . Cell Reports vol. 31 , ( 6 )
Cutmore LC, Brown NF, Raj D, Chauduri S, Wang P, Maher J, Wang Y, Lemoine NR et al. ( 2020 ) . Pancreatic Cancer UK Grand Challenge: Developments and challenges for effective CAR T cell therapy for pancreatic ductal adenocarcinoma . Pancreatology
Moore KM, Desai A, de Luxán Delgado B, Trabulo SMD, Reader C, Brown NF, Murray ER, Brentnall A et al. ( 2020 ) . Integrin αvβ6-specific therapy for pancreatic cancer developed from foot-and-mouth-disease virus . Theranostics vol. 10 , ( 7 ) 2930 - 2942 .
Clark E, Morton M, Sharma S, Fisher H, Howel D, Walker J, Wood R, Hancock H et al. ( 2019 ) . Prostate cancer androgen receptor splice variant 7 biomarker study - A multicentre randomised feasibility trial of biomarker-guided personalised treatment in patients with advanced prostate cancer (the VARIANT trial) study protocol . BMJ Open vol. 9 , ( 12 )
Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB et al. ( 2019 ) . The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy . Journal of Pathology vol. 249 , ( 3 ) 332 - 342 .
Brown NF, Marshall JF ( 2019 ) . Integrin-mediated TGFβ activation modulates the tumour microenvironment . Cancers vol. 11 , ( 9 )
Thomas JR, Moore KM, Sproat C, Mo S, Wolanska KI, Maldonado H, Haider S, Newman D et al. ( 2019 ) . Integrin alpha V beta 6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 100 , A39 - A39 .
Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratch T et al. ( 2019 ) . Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control . Faraday Discussions
Anderson RL, Balasas T, Callaghan J, Coombes RC, Evans J, Hall JA, Kinrade S, Jones D et al. ( 2019 ) . A framework for the development of effective anti-metastatic agents . Nat Rev Clin Oncol vol. 16 , ( 3 ) 185 - 204 .
HUANG D, PATEL K, Perez-Garrido S, MARSHALL J, PALMA M ( 2019 ) . DNA Origami Nanoarrays for Multivalent Investigations of Cancer Cell Spreading with Nanoscale Spatial Resolution and Single- Molecule Control . ACS Nano
Dreyer SB, Jamieson NB, Evers L, Duthie F, Cooke S, Marshall J, Beraldi D, Knight S et al. ( 2019 ) . Feasibility and clinical utility of endoscopic ultrasound guided biopsy of pancreatic cancer for next-generation molecular profiling . Chinese Clinical Oncology vol. 8 , ( 2 )
Velikova G, Williams LJ, Willis S, Dixon JM, Loncaster J, Hatton M, Clarke J, Kunkler IH et al. ( 2018 ) . Quality of life after postmastectomy radiotherapy in patients with intermediate-risk breast cancer (SUPREMO): 2-year follow-up results of a randomised controlled trial . The Lancet Oncology vol. 19 , ( 11 ) 1516 - 1529 .
Rudran B, Reader C, Foster J, Hodivala-Dilke K, Sosabowski J, Marshall J ( 2018 ) . P1.03-19 Antibody Blockade of Integrin Alpha-V-Beta-6 (avb6) as a Novel Treatment for NSCLC . Journal of Thoracic Oncology . vol. 13 , s518 - s519 .
Caley M, Martins V, Moore K, Lashari M, Marshall J, O'Toole E ( 2018 ) . Loss of Lam alpha 3 drives M2 macrophage differentiation in squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 178 , E399 - E400 .
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y et al. ( 2018 ) . PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer . Cell Reports vol. 22 , ( 9 ) 2469 - 2481 .
Man YKS, Davies JA, Coughlan L, Pantelidou C, Blázquez-Moreno A, Marshall JF, Parker AL, Halldén G ( 2018 ) . The novel oncolytic adenoviral mutant Ad5-3Δ-A20T retargeted to αvβ6 integrins efficiently eliminates pancreatic cancer cells . Molecular Cancer Therapeutics vol. 17 , ( 2 ) 575 - 587 .
Marshall JF ( 2018 ) . Targeting CDH17 in cancer: When blocking the ligand beats blocking the receptor? . Clinical Cancer Research vol. 24 , ( 2 ) 253 - 255 .
Rudran B, Reader C, Foster J, Hodivala-Dilke K, Sosabowski J, Marshall J ( 2018 ) . 12 Blockade of integrin alpha-v-beta-6 (αvβ6) reduces the invasive potential of NSCLC . Lung Cancer vol. 115 , s5 - s6 .
Rudran B, Reader C, Foster J, Hodivala-Dilke K, Sosabowski J, Marshall J ( 2018 ) . Blockade of integrin alpha-v-beta-6 (alpha v beta 6) reduces the invasive potential of NSCLC . LUNG CANCER . vol. 115 , S5 - S6 .
Pinnington SJL, Marshall JF, Wheeler AP ( 2018 ) . Correlative 3D Structured Illumination Microscopy and Single-Molecule Localization Microscopy for Imaging Cancer Invasion . Methods Mol Biol vol. 1764 , 253 - 265 .
Man YKS, Davies JA, Coughlan L, Pantelidou C, Marshall JF, Parker AL, Hallden G ( 2017 ) . The novel oncolytic adenoviral mutant Ad5-3 Delta-A20T retargeted to alpha v beta 6-integrins efficiently eliminates pancreatic cancer cells . HUMAN GENE THERAPY . Conference: IAM Mexico vol. 28 , A27 - A27 .
Caley M, Martins V, Moore K, Lashari M, Marshall J, O’Toole EA ( 2017 ) . 336 Tumour associated macrophage recruitment in SCC . Journal of Investigative Dermatology . vol. 137 ,
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RMG, Kao YV, Saxena SA, Romain A et al. ( 2017 ) . Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells . Molecular Therapy vol. 25 , ( 10 ) 2427 - 2427 .
Hayward M, Allen MD, Gomm JJ, Haywood L, Marshall JF, Jones LJ ( 2017 ) . Myoepithelial Cell Phenotype in DCIS Progression: Functional Significance of Integrin alpha v beta 6 and Fibronectin . JOURNAL OF PATHOLOGY . Conference: Belfast Pathology 2017 from: 20/06/2017 to: 23/06/2017 , vol. 243 , S16 - S16 .
Raab-Westphal S, Marshall JF, Goodman SL ( 2017 ) . Integrins as Therapeutic Targets: Successes and Cancers . Cancers (Basel) vol. 9 , ( 9 )
Hodgins NO, Al-Jamal WT, Wang JTW, Klippstein R, Costa PM, Sosabowski JK, Marshall JF, Maher J et al. ( 2017 ) . Investigating in vitro and in vivo αvβ6 integrin receptor-targeting liposomal alendronate for combinatory γδ T cell immunotherapy . Journal of Controlled Release vol. 256 , 141 - 152 .
Tod J, Hanley CJ, Morgan MR, Rucka M, Mellows T, Lopez M-A, Kiely P, Moutasim KA et al. ( 2017 ) . Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch . J Pathol vol. 243 , ( 1 ) 37 - 50 .
Hung K-Y, Harris PWR, Desai A, Marshall JF, Brimble MA ( 2017 ) . Structure-activity relationship study of the tumour-targeting peptide A20FMDV2 via modification of Lys16, Leu13, and N- and/or C-terminal functionality . Eur J Med Chem vol. 136 , 154 - 164 .
Sarper M, Allen MD, Gomm J, Haywood L, Decock J, Thirkettle S, Ustaoglu A, Sarker SJ et al. ( 2017 ) . Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function . Breast Cancer Research vol. 19 , ( 1 )
Rudran B, Desai A, Luzarraga M, Hodivala-Dilke K, Foster J, Sosabowski J, Marshall J ( 2017 ) . Development of non-invasive imaging of integrin alpha-v-beta-6 (alpha v beta 6)-positive lung cancers in advance of testing alpha v beta 6-targeted therapies . Lung Cancer . Conference: British Thoracic Oncology Group Conference 2017 ( Dublin, Ireland ) from: 25/01/2017 to: 27/01/2017 , vol. 103 , S4 - S4 .
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RMG, Kao YV, Saxena SA, Romain A et al. ( 2017 ) . Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells . Molecular Therapy vol. 25 , ( 1 ) 259 - 273 .
Rudran B, Desai A, Luzarraga M, Hodivala-Dilke K, Foster J, Sosabowski J, Marshall J ( 2017 ) . 6: Development of non-invasive imaging of integrin alpha-v-beta-6 (αvβ6)-positive lung cancers in advance of testing αvβ6-targeted therapies . Lung Cancer vol. 103 ,
Vallath S, Reader C, Morton J, Sansom O, Evans J, Biankin A, Barry ST, Kocher H et al. ( 2016 ) . Abstract B53: The integrin αvβ6 is a promising therapeutic target for treating PDAC . Conference: Molecular Drivers of Pancreatic Cancer Biology and Metastasisb53 - b53 .
Hayward M, Allen MD, Dreger S, Marshall JF, Jones JL ( 2016 ) . Investigating the Functional Significance of Aberrant alpha v beta 6 and Fibronectin Expression in Myoepithelial Cells: Role in the Progression of DCIS? . JOURNAL OF PATHOLOGY . Conference: Nottingham Pathology 2016 from: 28/06/2016 to: 01/07/2016 , vol. 240 , 28 - 28 .
Caley M, Martins V, Moore K, Lashari M, Kähäri V, Nissinen L, Donaldson M, Marshall J et al. ( 2016 ) . 472 Loss of Laminin α3 drives SCC invasion via ROCK signalling . Journal of Investigative Dermatology . vol. 136 ,
Heuser S, Hufbauer M, Steiger J, Marshall J, Sterner-Kock A, Mauch C, Zigrino P, Akgül B ( 2016 ) . The fibronectin/α3β1 integrin axis serves as molecular basis for keratinocyte invasion induced by βhPV . Oncogene vol. 35 , ( 34 ) 4529 - 4539 .
Huang D, Keseroglu K, Garrido S, Sapelkin A, Marshall J, Palma M ( 2016 ) . Single-molecule investigations via DNA nanostructures: A cell adhesion study . ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY . vol. 252 ,
Khan Z, Marshall JF ( 2016 ) . The role of integrins in TGFβ activation in the tumour stroma . Cell and Tissue Research vol. 365 , ( 3 ) 657 - 673 .
Man YKS, Pantelidou C, Blázquez-Moreno A, Coughlan L, Marshall J, Kocher H, Halldén G ( 2016 ) . Modifying oncolytic viral therapy for pancreatic cancer . Pancreatology vol. 16 , ( 3 )
Marshall J, Vallath S, Reader C, Morton J, Sansom O, Evans TRJ, Biankin A, Kocher HM ( 2016 ) . The integrin αvβ6 is a promising therapeutic target for treating PDAC . Pancreatology vol. 16 , ( 3 )
Caley M, Martins V, Moore K, Lashari M, Donaldson M, Marshall JF, O'Toole EA ( 2016 ) . ROCK and Rac1 signalling in squamous cell carcinoma with loss of laminin 332 . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E51 - E51 .
Allen N, Allen M, Gomm J, Hayward L, Ahmed K, Marshall J, Jones L ( 2016 ) . The role of Galectin-7 in normal and DCIS-associated myoepithelial cells: predicting progression of DCIS . European Journal of Surgical Oncology vol. 42 , ( 5 )
Slack RJ, Hafeji M, Rogers R, Ludbrook SB, Marshall JF, Flint DJ, Pyne S, Denyer JC ( 2016 ) . Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2 . Pharmacology vol. 97 , ( 3-4 ) 114 - 125 .
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic R, Violette S, Ghaem-Maghami S, Vallath S et al. ( 2016 ) . Abstract B129: Chimeric antigen receptor T-cells targeting the αvβ6 integrin demonstrate potent antitumor activity in multiple solid tumors . Conference: Preclinical Modelsb129 - b129 .
Greenman CD, Cooke SL, Marshall J, Stratton MR, Campbell PJ ( 2016 ) . Modeling the evolution space of breakage fusion bridge cycles with a stochastic folding process . Journal of Mathematical Biology vol. 72 , ( 1-2 ) 47 - 86 .
Pantelidou C, Man YKS, Coughlan L, Marshall J, Kocher H, Hallden G ( 2016 ) . Oncolytic adenoviral mutants deleted in the anti-apoptotic E1B19K gene sensitize pancreatic cancer cells to drug-induced DNA damage . INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE vol. 38 , S58 - S58 .
Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M et al. ( 2015 ) . Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC . J Natl Cancer Inst vol. 108 , ( 1 )
Paillas S, Desai A, Quetier I, Marshall J, Pouget J, Sosabowski J ( 2015 ) . Targeted Radionuclide Therapy using high-LET particle emitter-labeled vectors against alpha-v-beta6-expressing cancers . EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING . vol. 42 , S201 - S201 .
Martins V, Caley M, Moore K, Szentpetery Z, Marsh S, Murrell DF, Kaehaeri V, McGrath J et al. ( 2015 ) . Skin type VII collagen acts as a tumour suppressor by regulating TGF beta and angiogenesis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 135 , S28 - S28 .
Caley M, Martins V, Marsh S, Moore K, Lashari M, Donaldson MJ, Marshall J, O'toole E ( 2015 ) . Squamous Cell Carcinoma progression and Laminin 332 . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 135 , S23 - S23 .
Nik-Zainal S, Van Loo P, Wedge DC, Alexandrov LB, Greenman CD, Lau KW, Raine K, Jones D et al. ( 2015 ) . Erratum: The Life History of 21 Breast Cancers (Cell 149 (994-1007)) . Cell vol. 162 , ( 4 )
Reader CS, Vallath S, Morton J, Steele C, Kocher HM, Keyse SM, Sansom O, Marshall JF ( 2015 ) . Abstract B87: Cell lines generated from PDAC transgenic mice reveal integrin αvβ6 modifies the invasive phenotype of pancreatic cancer . Conference: New Therapiesb87 - b87 .
Moutasim KA, Mellows T, Marshall JF, Jenei V, Thomas GJ ( 2015 ) . Hedgehog Inhibition Results in the Upregulation of Pro-Tumourigenic αvβ6 Integrin Expression and Function in Cancer . Oral Surgery Oral Medicine Oral Pathology and Oral Radiology vol. 119 , ( 3 )
Rudran B, Marshall JF ( 2015 ) . 7: The integrin αvβ6: a new target for therapy in non-small cell lung cancer . Lung Cancer . vol. 87 ,
Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T et al. ( 2014 ) . A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma . Genome Medicine vol. 6 , ( 12 )
Allen MD, Marshall JF, Jones JL ( 2014 ) . αvβ6 Expression in myoepithelial cells: a novel marker for predicting DCIS progression with therapeutic potential . Cancer Res vol. 74 , ( 21 ) 5942 - 5947 .
Meier B, Cooke SL, Weiss J, Bailly AP, Alexandrov LB, Marshall J, Raine K, Maddison M et al. ( 2014 ) . C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency . Genome Research vol. 24 , ( 10 ) 1624 - 1636 .
Caley M, Martins V, Moore K, Marshall J, O'toole E ( 2014 ) . Diverse roles for laminin 332 subunits in squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S19 - S19 .
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al. ( 2014 ) . Therapeutic targeting of integrin αvβ6 in breast cancer . J Natl Cancer Inst vol. 106 , ( 8 )
Elosegui-Artola A, Bazellières E, Allen MD, Andreu I, Oria R, Sunyer R, Gomm JJ, Marshall JF et al. ( 2014 ) . Rigidity sensing and adaptation through regulation of integrin types . Nat Mater vol. 13 , ( 6 ) 631 - 637 .
Moutasim KA, Mellows T, Mellone M, Lopez M-A, Tod J, Kiely PC, Sapienza K, Greco A et al. ( 2014 ) . Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function . JOURNAL OF PATHOLOGY vol. 233 , ( 2 ) 196 - 208 .
Muhammad H, Taher T, Mullen L, Pastan I, Marshall J, Chernajovsky Y, Gould D, Mageed R ( 2014 ) . Development of a novel approach for targeted delivery of siRNA to B lymphocytes with a potential application in cancer . HUMAN GENE THERAPY . vol. 25 , A5 - A5 .
Caley M, Martins V, Moore K, Marshall J, O'Toole E ( 2014 ) . Diverse roles for laminin-332 subunits in squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 170 , E26 - E26 .
Vallath S, Scarpa A, Weinreb P, Violette S, Steele C, Morton J, Sansom O, Davies J et al. ( 2014 ) . The integrin αvβ6 is a promising target for the therapy of PDAC: toward phase I trials . Pancreatology vol. 14 , ( 2 )
Allen MD, Thomas GJ, Clark S, Dawoud MM, Vallath S, Payne SJ, Gomm JJ, Dreger SA et al. ( 2014 ) . Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence . Clin Cancer Res vol. 20 , ( 2 ) 344 - 357 .
Moore K, Thomas G, Duffy S, Warwick J, Gabe R, Chou P, Ellis I, Green A et al. ( 2013 ) . Abstract P4-15-01: Integrin avb6 is a therapeutic target for high-risk breast cancer and enhances trastuzumab efficacy .
John AE, Luckett JC, Tatler AL, Awais RO, Desai A, Habgood A, Ludbrook S, Blanchard AD et al. ( 2013 ) . Preclinical SPECT/CT Imaging of alpha v beta 6 Integrins for Molecular Stratification of Idiopathic Pulmonary Fibrosis . JOURNAL OF NUCLEAR MEDICINE vol. 54 , ( 12 ) 2146 - 2152 .
Ene-Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin-Aleong J et al. ( 2013 ) . Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma . Gastroenterology vol. 145 , ( 5 ) 1121 - 1132 .
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al. ( 2013 ) . Abstract B046: Therapeutic targeting of integrin αvβ6 in high-risk breast cancer . b046 - b046 .
Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K et al. ( 2013 ) . Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer . Breast Cancer Research vol. 15 , ( 5 )
Eberlein C, Kendrew J, McDaid K, Alfred A, Kang JS, Jacobs VN, Ross SJ, Rooney C et al. ( 2013 ) . A human monoclonal antibody 264RAD targeting alpha v beta 6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo . ONCOGENE vol. 32 , ( 37 ) 4406 - 4416 .
Tarpey PS, Behjati S, Cooke SL, Van Loo P, Wedge DC, Pillay N, Marshall J, Meara SO et al. ( 2013 ) . Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma . Nature Genetics vol. 45 , ( 8 ) 923 - 926 .
Caley MP, Martins V, Moore K, Marshall JF, O'Toole EA ( 2013 ) . Diverse roles for laminin 332 subunits in squamous cell carcinoma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S64 - S64 .
Martins VL, Caley MP, Moore K, Szentpetery Z, Murrell DF, Kim MH, McGrath JA, Cerio R et al. ( 2013 ) . Loss of type VII collagen in cutaneous SCC increases angiogenesis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S158 - S158 .
Sarper M, Allen MD, Decock J, Thirkettle S, Edwards DR, Marshall JF, Jones LJ ( 2013 ) . MMP-8 Loss Contributes to Altered Myoepithelial Cell Function in DCIS . JOURNAL OF PATHOLOGY . vol. 229 , S11 - S11 .
Ali I, Gautrot J, Caley M, Marshall JF, Wheeler A ( 2013 ) . Formation and inhibition of invadopodia in oral squamous cell carcinoma . MOLECULAR BIOLOGY OF THE CELL . vol. 24 ,
Kogelberg H, Miranda E, Burnet J, Ellison D, Tolner B, Foster J, Picón C, Thomas GJ et al. ( 2013 ) . Generation and characterization of a diabody targeting the αvβ6 integrin . PLoS One vol. 8 , ( 9 )
John AE, Luckett JC, Tatler AL, Awais RO, Habgood A, Ludbrook S, Blanchard A, Perkins AC et al. ( 2013 ) . Pre-Clinical Imaging Of The alpha v beta 6 Integrin For Molecular Stratification Of Idiopathic Pulmonary Fibrosis . AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE . vol. 187 ,
Elosegui-Artola A, Bazellieres E, Allen MD, Andreu I, Marshall JF, Jones JL, Trepat X, Roca-Cusachs P ( 2013 ) . Rigidity sensing and adaptation through regulation of integrin populations . MOLECULAR BIOLOGY OF THE CELL vol. 24 ,
Voet T, Kumar P, Van Loo P, Cooke SL, Marshall J, Lin ML, Esteki MZ, Van Der Aa N et al. ( 2013 ) . Single-cell paired-end genome sequencing reveals structural variation per cell cycle . Nucleic Acids Research vol. 41 , Article 12 , 6119 - 6138 .
Man YKS, DiCara D, Chan N, Vessillier S, Mather SJ, Rowe ML, Howard MJ, Marshall JF et al. ( 2013 ) . Structural guided scaffold phage display libraries as a source of bio-therapeutics . PLoS One vol. 8 , ( 8 )
John AE, Luckett J, Awas R, Habgood A, Ludbrook S, Blanchard A, Perkins A, Jenkins RG et al. ( 2012 ) . TARGETED IN VIVO IMAGING OF THE alpha V beta 6 INTEGRIN IN MICE WITH BLEOMYCIN-INDUCED LUNG FIBROSIS . THORAX . vol. 67 , A33 - A33 .
Awais RO, Mather SJ, John AE, Luckett JCA, Habgood A, Jenkins GR, Marshall JF, Perkins AC ( 2012 ) . NanoSPECT/CT imaging of pulmonary alpha v beta 6 with [In-111]A20FMDV2 as a surrogate marker for monitoring lung fibrosis . EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING . vol. 39 , S215 - S215 .
Martins V, Caley M, Moore K, Murrell DF, McGrath JA, Chen M, Marshall JF, O'Toole EA ( 2012 ) . Loss of keratinocyte type VII collagen in SCC increases TGF-beta signalling and angiogenesis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S45 - S45 .
Dreger SA, Payne SJ, Dawoud M, Robinson SD, Marshall JF, Hodivala-Dilke KM, Allen MD, Jones JL ( 2012 ) . Up-regulation of alpha v beta 6 integrin and fibronectin EDA in myoepithelial cells contribute to the angiogenic switch in pre-invasive breast cancer . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 93 , A24 - A24 .
Vallath S, Gadaletta E, Chelala C, Scarpa A, Hart IR, Kocher HM, Marshall JF ( 2012 ) . Abstract B42: Toward targeting integrin αvβ6 for the therapy of pancreatic cancer . Conference: Therapyb42 - b42 .
Ahmed KO, Allen M, Gomm J, Marshall J, Jones JL ( 2012 ) . 16P Myoepithelial Control of the Inflammatory Microenvironment Promotes Transition of Dcis to Invasive Disease . Annals of Oncology vol. 23 ,
Ahmed KO, Allen M, Gomm J, Marshall J, Jones JL ( 2012 ) . MYOEPITHELIAL CONTROL OF THE INFLAMMATORY MICROENVIRONMENT PROMOTES TRANSITION OF DCIS TO INVASIVE DISEASE . ANNALS OF ONCOLOGY . vol. 23 , 19 - 19 .
Martins V, Caley M, Moore K, Chen M, Marshall J, O'Toole E ( 2012 ) . Loss of type VII collagen in squamous cell carcinoma increases angiogenesis in vitro and in vivo . BRITISH JOURNAL OF DERMATOLOGY . vol. 166 , e25 - e26 .
Lines KE, Chelala C, Dmitrovic B, Wijesuriya N, Kocher HM, Marshall JF, Crnogorac-Jurcevic T ( 2012 ) . S100P-binding protein, S100PBP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells . Am J Pathol vol. 180 , ( 4 ) 1485 - 1494 .
Sarper M, Allen M, Decock J, Marshall JF, Edwards DR, Jones JL ( 2012 ) . Loss of MMP-8 Expression Contributes to Altered Myoepithelial Cell Function in DCIS . JOURNAL OF PATHOLOGY . vol. 226 , S13 - S13 .
Murchison EP, Schulz-Trieglaff OB, Ning Z, Alexandrov LB, Bauer MJ, Fu B, Hims M, Ding Z et al. ( 2012 ) . Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer . Cell vol. 148 , ( 4 ) 780 - 791 .
Wagstaff JL, Rowe ML, Hsieh S-J, DiCara D, Marshall JF, Williamson RA, Howard MJ ( 2012 ) . NMR relaxation and structural elucidation of peptides in the presence and absence of trifluoroethanol illuminates the critical molecular nature of integrin alpha v beta 6 ligand specificity . RSC ADVANCES vol. 2 , ( 29 ) 11019 - 11028 .
Moore K, Hart I, Jones L, Marshall J ( 2011 ) . P2-01-05: Integrin avb6 Mediates HER2−Driven Invasion in Breast Cancer .
Roy S, Bingle L, Marshall JF, Bass R, Ellis V, Speight PM, Whawell SA ( 2011 ) . The role of α9β1 integrin in modulating epithelial cell behaviour . Journal of Oral Pathology and Medicine vol. 40 , ( 10 ) 755 - 761 .
Martins VL, Moore K, Chen M, Marshall J, O'Toole EA ( 2011 ) . Loss of type VII collagen in SCC leads to increased invasion and TGF-beta signalling in vivo . BRITISH JOURNAL OF DERMATOLOGY . vol. 164 , 910 - 910 .
Martins V, Moore K, Chen M, Marshall J, O'Toole EA ( 2011 ) . Loss of type VII collagen in squamous cell carcinoma leads to increased invasion and TGF-beta signalling in vivo . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 131 , S33 - S33 .
Morgan MR, Jazayeri M, Ramsay AG, Thomas GJ, Boulanger MJ, Hart IR, Marshall JF ( 2011 ) . Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion . Oncogene vol. 30 , ( 12 ) 1422 - 1435 .
Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N et al. ( 2011 ) . Stromal features are predictive of disease mortality in oral cancer patients . J Pathol vol. 223 , ( 4 ) 470 - 481 .
Moutasim KA, Jenei V, Sapienza K, Marsh D, Weinreb PH, Violette SM, Lewis MP, Marshall JF et al. ( 2011 ) . Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis . J Pathol vol. 223 , ( 3 ) 366 - 377 .
Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D et al. ( 2011 ) . Exome sequencing identifies frequent mutation of the SWI/SNF Complex Gene PBRM1 in renal carcinoma . nature vol. 186 , Article 3 , 1150 - 1150 .
Marshall J ( 2011 ) . Transwell(®) invasion assays . Methods Mol Biol vol. 769 , 97 - 110 .
Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N et al. ( 2010 ) . Stromal features are predictive of disease mortality in oral cancer patients . J Pathol
Moutasim KA, Jenei V, Sapienza K, Marsh D, Weinreb PH, Violette SM, Lewis MP, Marshall JF et al. ( 2010 ) . Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis . J Pathol
Sapienza K, Sale S, Hague A, Hart IR, Marshall JF, Thomas GJ ( 2010 ) . EP4-mediated prostanoid signalling promotes oral cancer progression . BMC Proceedings vol. 4 , ( Suppl 2 )
Moutasim KA, Jenei V, Sapienza K, Marsh D, Marshall J, Fortune F, Tilakaratne WM, Hart IR et al. ( 2010 ) . Alkaloid-dependent upregulation of AlphavBeta6 integrin promotes oral submucous fibrosis . ORAL DIS vol. 16 , ( 6 ) 528 - 528 .
Saha A, Ellison D, Thomas GJ, Vallath S, Mather SJ, Hart IR, Marshall JF ( 2010 ) . High-resolution in vivo imaging of breast cancer by targeting the pro-invasive integrin alphavbeta6 . J Pathol vol. 222 , ( 1 ) 52 - 63 .
Froeling FEM, Marshall JF, Kocher HM ( 2010 ) . Pancreatic cancer organotypic cultures . J Biotechnol vol. 148 , ( 1 ) 16 - 23 .
Sampaio ALF, Zahn G, Leoni G, Vossmeyer D, Christner C, Marshall JF, Perretti M ( 2010 ) . Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis . J Leukoc Biol vol. 87 , ( 5 ) 877 - 884 .
Alexopoulou AN, Leao M, Caballero OL, Da Silva L, Reid L, Lakhani SR, Simpson AJ, Marshall JF et al. ( 2010 ) . Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines . Breast Cancer Res vol. 12 , ( 4 )
Wagstaff JL, Vallath S, Marshall JF, Williamson RA, Howard MJ ( 2010 ) . Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin alpha v beta 6 protein-peptide interactions . CHEM COMMUN vol. 46 , ( 40 ) 7533 - 7535 .
Payne SJL, Allen M, Dreger S, Marshall J, Hodiavala-Dilke K, Hart I, Jones L ( 2009 ) . Myoepithelial Cells in DCIS Exhibit an Altered Phenotype and Promote Angiogenesis . CANCER RESEARCH . vol. 69 , 642S - 643S .
Robinson SD, Reynolds LE, Kostourou V, Reynolds AR, da Silva RG, Tavora B, Baker M, Marshall JF et al. ( 2009 ) . Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis . J Biol Chem vol. 284 , ( 49 ) 33966 - 33981 .
Gagnon MKJ, Hausner SH, Marik J, Abbey CK, Marshall JF, Sutcliffe JL ( 2009 ) . High-throughput in vivo screening of targeted molecular imaging agents . P NATL ACAD SCI USA vol. 106 , ( 42 ) 17904 - 17909 .
Hausner SH, Abbey CK, Bold RJ, Gagnon MK, Marik J, Marshall JF, Stanecki CE, Sutcliffe JL ( 2009 ) . Targeted In vivo Imaging of Integrin alpha(v)beta(6) with an Improved Radiotracer and Its Relevance in a Pancreatic Tumor Model . CANCER RES vol. 69 , ( 14 ) 5843 - 5850 .
Coughlan L, Vallath S, Saha A, Flak M, McNeish IA, Vassaux G, Marshall JF, Hart IR et al. ( 2009 ) . In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery . J Virol vol. 83 , ( 13 ) 6416 - 6428 .
Coughlan L, Vallath S, Saha A, McNeish IA, Vassaux G, Marshall JF, Hart IR, Thomas GJ ( 2009 ) . An Ad5 Vector Retargeted to alpha v beta 6 Displays Improved Tumour Transduction Combined with Reduced Liver Uptake Following Systemic Delivery . MOLECULAR THERAPY . vol. 17 , S323 - S323 .
Sampaio ALF, Leoni G, Marshall JF, Perretti M ( 2009 ) . A role for alpha 5 beta 1 integrin in leukocyte accumulation in acute peritonitis . EUR J CLIN INVEST . vol. 39 , 22 - 23 .
Hausner SH, Kukis DL, Gagnon MKJ, Stanecki CE, Ferdani R, Marshall JF, Anderson CJ, Sutcliffe JL ( 2009 ) . Evaluation of [Cu-64]Cu-DOTA and [Cu-64]Cu-CB-TE2A Chelates for Targeted Positron Emission Tomography with an alpha(v)beta(6)-Specific Peptide . MOL IMAGING vol. 8 , ( 2 ) 111 - 121 .
Kogelberg H, Tolner B, Thomas GJ, Di Cara D, Minogue S, Ramesh B, Sodha S, Marsh D et al. ( 2008 ) . Engineering a single-chain Fv antibody to alpha v beta 6 integrin using the specificity-determining loop of a foot-and-mouth disease virus . J Mol Biol vol. 382 , ( 2 ) 385 - 401 .
Coughlan L, McNeish I, Vassaux G, Marshall J, Hart IR, Thomas G ( 2008 ) . Transductional retargeting of adenovirus-5 to alphavbeta6 integrin . HUMAN GENE THERAPY . vol. 19 , 1102 - 1102 .
Lees DM, Hart IR, Marshall JF ( 2008 ) . Existence of multiple isoforms of HS1-associated protein X-1 in murine and human tissues . J Mol Biol vol. 379 , ( 4 ) 645 - 655 .
Roy S, Marshall JF, Speight PM, Whawell SA ( 2008 ) . Role of alpha 9 beta 1 integrin in the regulation of epithelial cell behaviour . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 89 , A8 - A9 .
Marsh D, Dickinson S, Neill GW, Marshall JF, Hart IR, Thomas GJ ( 2008 ) . alpha v beta 6 integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation . CANCER RES vol. 68 , ( 9 ) 3295 - 3303 .
Dicara D, Burman A, Clark S, Berryman S, Howard MJ, Hart IR, Marshall JF, Jackson T ( 2008 ) . Foot-and-mouth disease virus forms a highly stable, EDTA-resistant complex with its principal receptor, integrin alphavbeta6: implications for infectiousness . J Virol vol. 82 , ( 3 ) 1537 - 1546 .
Allen M, Mulligan K, Clark S, Hart I, Marshall JF, Jones JL ( 2008 ) . De novo expression of alpha(v)beta(6) integrin by myoepithelial cells in ductal carcinoma in situ may be an important marker of disease progression . BREAST CANCER RESEARCH . vol. 10 , S16 - S16 .
Jones JL, Thomas GJ, Duffy SW, Gabe R, Ellis I, Green A, Saha A, Mulligan KT et al. ( 2007 ) . Expression of alphavbeta6 supersedes Her2 and triple-negative/basal classification of breast cancer and defines novel subgroups with poor survival: implications for breast cancer classification and treatment . BREAST CANCER RESEARCH AND TREATMENT . vol. 106 , S11 - S11 .
Gaggioli C, Hooper S, Hidalgo-Carcedo C, Grosse R, Marshall JF, Harrington K, Sahai E ( 2007 ) . Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells . Nat Cell Biol vol. 9 , ( 12 ) 1392 - 1400 .
Ramsay AG, Marshall JF, Hart IR ( 2007 ) . Integrin trafficking and its role in cancer metastasis . Cancer Metastasis Rev vol. 26 , ( 3-4 ) 567 - 578 .
Clark SE, Marshall JE, Hart IR, Carpenter R, Jones JL ( 2007 ) . Molecular profiling of DCIS: identification of distinct subgroups of potential prognostic importance . BREAST CANCER RESEARCH AND TREATMENT . vol. 106 , S221 - S221 .
Hausner SH, DiCara D, Marik J, Marshall JF, Sutcliffe JL ( 2007 ) . Use of a peptide derived from foot-and-mouth disease virus for the Noninvasive Imaging of human cancer: Generation and evaluation of 4-[F-18]fluorobenzoyl A20FMDV2 for in vivo imaging of integrin alpha(v)beta(6) expression with positron emission tomography . CANCER RES vol. 67 , ( 16 ) 7833 - 7840 .
Ramsay AG, Keppler MD, Jazayeri M, Thomas GJ, Parsons M, Violette S, Weinreb P, Hart IR et al. ( 2007 ) . HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6 . Cancer Res vol. 67 , ( 11 ) 5275 - 5284 .
DiCara D, Rapisarda C, Sutcliffe JL, Violette SM, Weinreb PH, Hart IR, Howard MJ, Marshall JF ( 2007 ) . Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands . J Biol Chem vol. 282 , ( 13 ) 9657 - 9665 .
Nystrom ML, McCulloch D, Weinreb PH, Violette SM, Speight PM, Marshall JF, Hart IR, Thomas GJ ( 2006 ) . Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion . Cancer Res vol. 66 , ( 22 ) 10833 - 10842 .
Hart I, Dicara D, Marshall JF ( 2006 ) . Targeting the invasion-association integrin alphavbeta6 as an anti-carcinoma strategy . EJC SUPPL vol. 4 , ( 12 ) 82 - 82 .
Thomas GJ, Nyström ML, Marshall JF ( 2006 ) . Alphavbeta6 integrin in wound healing and cancer of the oral cavity . J Oral Pathol Med vol. 35 , ( 1 ) 1 - 10 .
Allen M, Mulligan K, Clark S, Hart I, Marshall JF, Jones JL ( 2006 ) . Functional analysis of normal and DCIS modified breast myoepithelial cells . BREAST CANCER RESEARCH . vol. 8 , S9 - S9 .
Salama I, Mihaimeed F, Marshall J, Jazayeri M, Thomas G, Duffy S, Jones LJ ( 2006 ) . S100A7 and the basal phenotype in breast cancer . BREAST CANCER RESEARCH AND TREATMENT . vol. 100 , S159 - S159 .
Hooper S, Marshall JF, Sahai E ( 2006 ) . Tumor cell migration in three dimensions . Methods Enzymol vol. 406 , 625 - 643 .
Ylipalosaari M, Thomas GJ, Nystrom M, Salhimi S, Marshall JF, Huotari V, Tervahartiala T, Sorsa T et al. ( 2005 ) . alpha v beta 6 integrin down-regulates the MMP-13 expression in oral squamous cell carcinoma cells . EXP CELL RES vol. 309 , ( 2 ) 273 - 283 .
Vyas J, Ahmed W, Jayazeri M, Marshall JF, Proby CM, Storey A, O'Toole EA ( 2005 ) . Mechanisms of migration and invasion of squamous cell carcinoma in an in vitro model of squamous cell carcinogenesis . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 843 - 843 .
Vyas JJ, Ahmed W, Jayazeri M, Baksh N, Marshall JF, Proby CM, Storey A, O'Toole EA ( 2005 ) . Migration and invasion mechanisms in an in vitro model of squamous cell carcinogenesis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 124 , A22 - A22 .
Nyström ML, Thomas GJ, Stone M, Mackenzie IC, Hart IR, Marshall JF ( 2005 ) . Development of a quantitative method to analyse tumour cell invasion in organotypic culture . J Pathol vol. 205 , ( 4 ) 468 - 475 .
Scott KA, Arnott CH, Robinson SC, Moore RJ, Thompson RG, Marshall JF, Balkwill FR ( 2004 ) . TNF-alpha regulates epithelial expression of MMP-9 and integrin alphavbeta6 during tumour promotion. A role for TNF-alpha in keratinocyte migration? . Oncogene vol. 23 , ( 41 ) 6954 - 6966 .
Nystrom M, Stone M, Thomas GJ, Mackenzie I, Hart IR, Marshall JF ( 2004 ) . A quantitative method for measuring three-dimensional invasion in vitro using organotypic cultures . BRITISH JOURNAL OF CANCER . vol. 91 , S58 - S58 .
Lygoe KA, Norman JT, Marshall JF, Lewis MP ( 2004 ) . alpha v integrins play an important role in myofibroblast differentiation . WOUND REPAIR REGEN vol. 12 , ( 4 ) 461 - 470 .
Morgan MR, Thomas GJ, Russell A, Hart IR, Marshall JF ( 2004 ) . The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9 . J Biol Chem vol. 279 , ( 25 ) 26533 - 26539 .
Huntley SP, Davies M, Matthews JB, Thomas G, Marshall J, Robinson CM, Eveson JW, Paterson IC et al. ( 2004 ) . Attenuated type II TGF-B receptor signalling in human malignant oral keratinocytes induces a less differentiated and more aggressive phenotype that is associated with metastatic dissemination . INT J CANCER vol. 110 , ( 2 ) 170 - 176 .
HART IR, Joshi D, Marshall JF, Russel A, Thomas GJ, Morgan MR ( 2004 ) . The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote MMP-2 or MMP-9-mediated tumour cell invasion . J. Biol. Chem vol. 279 , 26533 - 26539 .
Dalvi N, Thomas GJ, Marshall JF, Morgan M, Bass R, Ellis V, Speight PM, Whawell SA ( 2004 ) . Modulation of the urokinase-type plasminogen activator receptor by the beta 6 integrin subunit . BIOCHEM BIOPH RES CO vol. 317 , ( 1 ) 92 - 99 .
Zhu G, Gilchrist R, Borley N, Chng HW, Morgan M, Marshall JF, Camplejohn RS, Muir GH et al. ( 2004 ) . Reduction of TSG101 protein has a negative impact on tumor cell growth . INT J CANCER vol. 109 , ( 4 ) 541 - 547 .
Lewis MP, Lygoe KA, Nystrom ML, Anderson WP, Speight PM, Marshall JF, Thomas GJ ( 2004 ) . Tumour-derived TGF-beta 1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells . BRIT J CANCER vol. 90 , ( 4 ) 822 - 832 .
Bukhary SM, Assmann V, Marshall JF, Speight PM, Thomas GJ ( 2003 ) . Restoration of e-cadherin function alters morphology of oral squamous carcinoma cells . JOURNAL OF DENTAL RESEARCH . vol. 82 , 485 - 485 .
Thomas GJ, Hart IR, Marshall JF, Speight PM ( 2003 ) . av beta 6 integrin interaction with the tgf-beta 1 latency-associated peptide (lap) . JOURNAL OF DENTAL RESEARCH . vol. 82 , 485 - 485 .
Morgan MR, Thomas GJ, Marshall JF ( 2003 ) . b6-integrin cytoplasmic tail: novel intracellular target for inhibiting oral scc invasion . JOURNAL OF DENTAL RESEARCH . vol. 82 , 472 - 472 .
Wan H, Stone MG, Simpson C, Reynolds LE, Marshall JF, Hart IR, Hodivala-Dilke KM, Eady RAJ ( 2003 ) . Desmosomal proteins, including desmoglein 3, serve as novel negative markers for epidermal stem cell-containing population of keratinocytes . J CELL SCI vol. 116 , ( 20 ) 4239 - 4248 .
Drayton S, Rowe J, Jones R, Vatcheva R, Cuthbert-Heavens D, Marshall J, Fried M, Peters G ( 2003 ) . Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes . Cancer Cell vol. 4 , ( 4 ) 301 - 310 .
South AP, Wan H, Stone MG, Dopping-Hepenstal PJC, Purkis PE, Marshall JF, Leigh IM, Eady RAJ et al. ( 2003 ) . Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability . J CELL SCI vol. 116 , ( 16 ) 3303 - 3314 .
Zhu G, Reynolds L, Crnogorac-Jurcevic T, Gillett CE, Dublin EA, Marshall JF, Barnes D, D'Arrigo C et al. ( 2003 ) . Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer . Oncogene vol. 22 , ( 24 ) 3742 - 3748 .
VAN TRAPPEN P ( 2003 ) . Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer . Oncogene vol. 22 , 3742 - 3748 .
Morgan MR, Thomas GJ, Marshall JF ( 2003 ) . beta 6-integrin cytoplasmic tail: Novel intracellular target for inhibiting oral SCC invasion . J DENT RES vol. 82 , B327 - B327 .
Hampton R, Walker M, Marshall J, Juhl H ( 2002 ) . Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells . ONCOGENE vol. 21 , ( 51 ) 7817 - 7823 .
Thomas GJ, Hart IR, Speight PM, Marshall JF ( 2002 ) . Binding of TGF-beta 1 latency-associated peptide (LAP) to alpha v beta 6 integrin modulates behaviour of squamous carcinoma cells . BRIT J CANCER vol. 87 , ( 8 ) 859 - 867 .
Sutcliffe-Goulden JL, O'Doherty MJ, Marsden PK, Hart IR, Marshall JF, Bansal SS ( 2002 ) . Rapid solid phase synthesis and biodistribution of F-18-labelled linear peptides . EUR J NUCL MED MOL I vol. 29 , ( 6 ) 754 - 759 .
Morgan MR, Thomas GJ, Russell A, Speight PM, Hart IR, Marshall JF ( 2002 ) . The ss 6 integrin subunit C-terminal 11 amino acids are sufficient to promote invasion by squamous cell carcinoma (SCC) cells . BRIT J CANCER vol. 86 , S120 - S120 .
Sutcliffe-Goulden JL, Marshall JF, O'Doherty MJ, Bansal S ( 2002 ) . Solid phase synthesis of F-18-labelled cyclic peptides . J NUCL MED vol. 43 , ( 5 ) 365P - 365P .
Cassidy J, Twelves C, Van Cutsem E, Hoff P, Bajetta E, Boyer M, Bugat R, Burger U et al. ( 2002 ) . First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin . ANN ONCOL vol. 13 , ( 4 ) 566 - 575 .
Thomas GJ, Lewis MP, Marshall JF, Speight PM ( 2001 ) . O-029. αvβ6 integrin promotes invasion of squamous carcinoma cells through upregulation of MMP-9 . Oral Oncology vol. 37 , ( SUPPL. 1 )
Davison E, Kirby I, Whitehouse J, Hart I, Marshall JF, Santis G ( 2001 ) . Adenovirus type 5 uptake by lung adenocarcinoma cells in culture correlates with Ad(5) fibre binding is mediated by alpha(v)beta(1) integrin and can be modulated by changes in beta(1) integrin function . J GENE MED vol. 3 , ( 6 ) 550 - 559 .
Thomas GJ, Lewis MP, Whawell SA, Russell A, Sheppard D, Hart IR, Speight PM, Marshall JF ( 2001 ) . Expression of the alpha v beta 6 integrin promotes migration and invasion in squamous carcinoma cells . J INVEST DERMATOL vol. 117 , ( 1 ) 67 - 73 .
Gilchrist R, Stafford H, Duddy PM, Marshall JF, Camplejohn RS, Hart IR ( 2001 ) . Mechanisms of adhesion-dependence in mouse melanocyte-derived cell lines . BRIT J CANCER vol. 85 , 82 - 82 .
Morgan MR, Thomas GJ, Speight PM, Hart IR, Marshall JF ( 2001 ) . The terminal 11a.a. cytoplasmic tail of the beta 6 integrin subunit is essential for the promotion of alpha V beta 6-dependent invasion . BRIT J CANCER vol. 85 , 22 - 22 .
Thomas GJ, Lewis MP, Hart IR, Marshall JF, Speight PM ( 2001 ) . alpha V beta 6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9 . INT J CANCER vol. 92 , ( 5 ) 641 - 650 .
Thomas GJ, Poomsawat S, Lewis MP, Hart IR, Speight PM, Marshall JF ( 2001 ) . alpha v beta 6 integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes . J INVEST DERMATOL vol. 116 , ( 6 ) 898 - 904 .
Thomas GJ, Poomsawat S, Lewis MP, Marshall JF, Speight PM ( 2001 ) . alpha v beta 6-dependent upregulation of MMP-9 promotes keratinocyte migration . J DENT RES vol. 80 , ( 4 ) 1155 - 1155 .
Hapke S, Gawaz M, Dehne K, Kohler J, Marshall JF, Graeff H, Schmitt M, Reuning U et al. ( 2001 ) . beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoter . MOL CELL BIOL vol. 21 , ( 6 ) 2118 - 2132 .
Brunton VG, Fincham VJ, McLean GW, Winder SJ, Paraskeva C, Marshall JF, Frame MC ( 2001 ) . The protrusive phase and full development of integrin-dependent adhesions in colon epithelial cells require FAK- and ERK-mediated actin spike formation: Deregulation in cancer cells . Neoplasia vol. 3 , ( 3 ) 215 - 226 .
Thorne RF, Marshall JF, Shafren DR, Gibson PG, Hart IR, Burns GF ( 2000 ) . The integrins α<inf>3</inf>β<inf>1</inf> and α<inf>6</inf>β<inf>1</inf> physically and functionally associate with CD36 in human melanoma cells: Requirement for the extracellular domain of CD36 . Journal of Biological Chemistry vol. 275 , ( 45 ) 35264 - 35275 .
Mitjans F, Meyer T, Fittschen C, Goodman S, Jonczyk A, Marshall JF, Reyes G, Piulats J ( 2000 ) . In vivo therapy of malignant melanoma by means of antagonists of αv integrins . International Journal of Cancer vol. 87 , ( 5 ) 716 - 723 .
Von Schlippe M, Marshall JF, Perry P, Stone M, Zhu AJ, Hart IR ( 2000 ) . Functional interaction between E-cadherin and αv-containing integrins in carcinoma cells . Journal of Cell Science vol. 113 , ( 3 ) 425 - 437 .
Sullivan RM, Stone M, Marshall JF, Uberall F, Rotenberg SA ( 2000 ) . Photo-induced inactivation of protein kinase Cα by dequalinium inhibits motility of murine melanoma cells . Molecular Pharmacology vol. 58 , ( 4 ) 729 - 737 .
Prest SJ, Rees RC, Murdoch C, Marshall JF, Cooper PA, Bibby M, Li G, Ali S ( 1999 ) . Chemokines induce the cellular migration of MCF-7 human breast carcinoma cells: Subpopulations of tumour cells display positive and negative chemotaxis and differential in vivo growth potentials . Clinical and Experimental Metastasis vol. 17 , ( 5 ) 389 - 396 .
Marshall JF, Hart IR ( 1999 ) . The Role of Adhesion in Metastasis:. Potential Mechanisms and Modulation of Integrin Activity . Advances in Molecular and Cell Biology vol. 28 , ( C ) 345 - 365 .
Assmann V, Jenkinson D, Marshall JF, Hart IR ( 1999 ) . The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments . Journal of Cell Science vol. 112 , ( 22 ) 3943 - 3954 .
Geng L, Ali SA, Marshall JF, Mackay CL, Hart IR, Delcommence M, Streuli CH, Rees RC ( 1998 ) . Fibronectin is chemotactic for CT 26 colon carcinoma cells: Sub-lines selected for increased chemotaxis to fibronectin display decreased tumorigenicity and lung colonization . Clinical and Experimental Metastasis vol. 16 , ( 8 ) 683 - 691 .
Assmann V, Marshall JF, Fieber C, Hofmann M, Hart IR ( 1998 ) . The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells . Journal of Cell Science vol. 111 , ( 12 ) 1685 - 1694 .
Marshall JF, Rutherford DC, Happerfield L, Hanby A, McCartney ACE, Newton-Bishop J, Hart IR ( 1998 ) . Comparative analysis of integrins in vitro and in vivo in uveal and cutaneous melanomas . British Journal of Cancer vol. 77 , ( 4 ) 522 - 529 .
Meyer T, Marshall JF, Hart IR ( 1998 ) . Expression of αv integrins and vitronectin receptor identity in breast cancer cells . British Journal of Cancer vol. 77 , ( 4 ) 530 - 536 .
Hasan NM, Adams GE, Joiner MC, Marshall JF, Hart IR ( 1998 ) . Hypoxia facilitates tumour cell detachment by reducing expression of surface adhesion molecules and adhesion to extracellular matrices without loss of cell viability . British Journal of Cancer vol. 77 , ( 11 ) 1799 - 1805 .
Saini A, Seller Z, Davies D, Marshall JF, Hart IR ( 1997 ) . Activation status and function of the VLA-4 (α4β1) integrin expressed on human melanoma cell lines . International Journal of Cancer vol. 73 , ( 2 ) 264 - 270 .
Ahmad A, Marshall JF, Basset P, Anglard P, Hart IR ( 1997 ) . Modulation of human stromelysin 3 promoter activity and gene expression by human breast cancer cells . International Journal of Cancer vol. 73 , ( 2 ) 290 - 296 .
Vile RG, Castleden S, Marshall J, Camplejohn R, Uptov C, Chong H ( 1997 ) . Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression . International Journal of Cancer vol. 71 , ( 2 ) 267 - 274 .
Davison E, Diaz RM, Hart IR, Santis G, Marshall JF ( 1997 ) . Integrin α5β1-mediated adenovirus infection is enhanced by the integrin-activating antibody TS2/16 . Journal of Virology vol. 71 , ( 8 ) 6204 - 6207 .
Francia G, Mitchell SD, Moss SE, Hanby AM, Marshall JF, Hart IR ( 1996 ) . Identification by differential display of Annexin-VI, a gene differentially expressed during melanoma progression . Cancer Research vol. 56 , ( 17 ) 3855 - 3858 .
Marshall JF, Hart IR ( 1996 ) . The role of αv-integrins in tumour progression and metastasis . Seminars in Cancer Biology vol. 7 , ( 3 ) 129 - 138 .
Marshall JF, Rutherford DC, McCartney ACE, Mitjans F, Goodman SL, Hart IR ( 1995 ) . α(v)β<inf>1</inf> is a receptor for vitronectin and fibrinogen, and acts with α<inf>5</inf>β<inf>1</inf> to mediate spreading on fibronectin . Journal of Cell Science vol. 108 , ( 3 ) 1227 - 1238 .
van Bruggen N, Chan WS, Syha J, Marshall JF, Proctor E, Williams SR, Gadian DG, Hart IR ( 1992 ) . Cell and tissue responses of a murine tumour to phthalocyanine-mediated photodynamic therapy . European Journal of Cancer vol. 28 , ( 1 ) 42 - 46 .
Hart IR, Birch M, Marshall JF ( 1991 ) . Cell adhesion receptor expression during melanoma progression and metastasis . CANCER AND METASTASIS REVIEW vol. 10 , ( 2 ) 115 - 128 .
Marshall JF, Nesbitt SA, Helfrich MH, Horton MA, Polakova K, Hart IR ( 1991 ) . Integrin expression in human melanoma cell lines: Heterogeneity of vitronectin receptor composition and function . International Journal of Cancer vol. 49 , ( 6 ) 924 - 931 .
Chan WS, Marshall JF, Hart IR, Svensen R, Bedwell J ( 1990 ) . Effect of Sulfonation on the Cell and Tissue Distribution of the Photosensitizer Aluminum Phthalocyanine . Cancer Research vol. 50 , ( 15 ) 4533 - 4538 .
MARSHALL JF, CHAN W, HART IR ( 1989 ) . EFFECT OF PHOTODYNAMIC THERAPY ON ANTITUMOR IMMUNE DEFENSES: COMPARISON OF THE PHOTOSENSITIZERS HEMATOPORPHYRIN DERIVATIVE AND CHLORO‐ALUMINUM SULFONATED PHTHALOCYANINE . Photochemistry and Photobiology vol. 49 , ( 5 ) 627 - 632 .
Chan WS, Marshall JF, Hart IR ( 1989 ) . Effect of tumour location on selective uptake and retention of phthalocyanines . Cancer Letters vol. 44 , ( 1 ) 73 - 77 .
Chan WS, Marshall JF, Lam GY, Hart IR ( 1988 ) . Tissue Uptake, Distribution, and Potency of the Photoactivatable Dye Chloroaluminum Suffonated Phthalocyanine in Mice Bearing Transplantable Tumors . Cancer Research vol. 48 , ( 11 ) 3040 - 3044 .
Chan W, Marshall JF, Hart IR ( 1987 ) . PHOTODYNAMIC THERAPY OF A MURINE TUMOR FOLLOWING SENSITISATION WITH CHLORO ALUMINUM SULFONATED PHTHALOCYANINE . Photochemistry and Photobiology vol. 46 , ( 5 ) 867 - 871 .
Chan W, Marshall JF, Svensen R, Phillips D, Hart IR ( 1987 ) . PHOTOSENSITISING ACTIVITY OF PHTHALOCYANINE DYES SCREENED AGAINST TISSUE CULTURE CELLS . Photochemistry and Photobiology vol. 45 , 757 - 761 .