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Research

Publications: Prof Kenneth Linton

Sasitharan K, Iqbal HA, Bifsa F, Olszewska A, Linton KJ ( 2021 ) . ABCB1 does not require the side-chain hydrogen-bond donors Gln<sup>347</sup>, Gln<sup>725</sup>, Gln<sup>990</sup> to confer cellular resistance to the anticancer drug taxol . International Journal of Molecular Sciences vol. 22 , ( 16 )
Emmanouilidi A, Casari I, Akkaya BG, Maffucci T, Furic L, Guffanti F, Broggini M, Chen X et al. ( 2020 ) . Inhibition of the lysophosphatidylinositol transporter abcc1 reduces prostate cancer cell growth and sensitizes to chemotherapy . Cancers vol. 12 , ( 8 ) 1 - 19 .
Goodchild E, Stoetaert J, Drake W, Linton K, Brown MJ ( 2020 ) . OR09-05 Expression of SLC35F1 in the Plasma Membrane of Cells of Aldosterone Producing Cell Clusters (APCCs) and Its Possible Role in Aldosterone Synthesis . Journal of the Endocrine Society vol. 4 , ( Suppl 1 )
Meyre D, Andress EJ, Sharma T, Snippe M, Asif H, Maharaj A, Vatin V, Gaget S et al. ( 2019 ) . Contribution of rare coding mutations in CD36 to type 2 diabetes and cardio-metabolic complications . Scientific Reports vol. 9 , ( 1 )
Adamska A, Domenichini A, Capone E, Damiani V, Akkaya BG, Linton KJ, Di Sebastiano P, Chen X et al. ( 2019 ) . Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer . Journal of Experimental and Clinical Cancer Research vol. 38 , ( 1 )
Adamska A, Ferro R, Lattanzio R, Capone E, Domenichini A, Damiani V, Chiorino G, Akkaya BG et al. ( 2019 ) . ABCC3 is a novel target for the treatment of pancreatic cancer . Advances in Biological Regulation vol. 73 ,
Kawecki C, Bocquet O, Schmelzer CEH, Heinz A, Ihling C, Wahart A, Romier B, Bennasroune A et al. ( 2019 ) . Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex . Cellular and Molecular Life Sciences vol. 76 , ( 4 ) 791 - 807 .
Rahman MM, Hazan A, Selway JL, Herath DS, Harwood CA, Pirzado MS, Atkar R, Kelsell DP et al. ( 2018 ) . A novel mechanism for activation of GLI1 by nuclear SMO that escapes anti-SMO inhibitors . Cancer Research vol. 78 , ( 10 ) 2577 - 2588 .
Andress EJ, Nicolaou M, McGeoghan F, Linton KJ ( 2017 ) . ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population . Cell Mol Life Sci
Linton KJ ( 2015 ) . Lipid flopping in the liver . Biochemical Society Transactions vol. 43 , 1003 - 1010 .
Akkaya BG, Zolnerciks JK, Ritchie TK, Bauer B, Hartz AMS, Sullivan JA, Linton KJ ( 2015 ) . The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1 . Molecular Membrane Biology vol. 32 , ( 2 ) 39 - 45 .
Sanders D, Zampronio CG, Nettleship JE, Owens RJ, Owen C, Linton KJ ( 2014 ) . Characterisation of the scavenger receptor CD36 . BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE vol. 92 , ( 6 ) 587 - 587 .
Zolnerciks JK, Akkaya BG, Snippe M, Chiba P, Seelig A, Linton KJ ( 2014 ) . The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle . FASEB J vol. 28 , ( 10 ) 4335 - 4346 .
Andress EJ, Nicolaou M, Romero MR, Naik S, Dixon PH, Williamson C, Linton KJ ( 2014 ) . A molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4 . Hepatology
Janha RE, Worwui A, Linton KJ, Shaheen SO, Sisay-Joof F, Walton RT ( 2014 ) . Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution . BMC Evol Biol vol. 14 ,
Blaydon DC, Lind LK, Plagnol V, Linton KJ, Smith FJD, Wilson NJ, McLean WHI, Munro CS et al. ( 2013 ) . Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma . Am J Hum Genet vol. 93 , ( 2 ) 330 - 335 .
Blaydon DC, Lind L, Plagnol V, Linton KJ, South AP, Leigh IM, O'Toole EA, Lundstrom A et al. ( 2013 ) . Aquaporin 5 (AQP5), a water channel protein, is mutated in autosomal dominant diffuse non-epidermolytic palmoplantar keratoderma . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S139 - S139 .
Falasca M, Linton KJ ( 2012 ) . Investigational ABC transporter inhibitors . Expert Opin Investig Drugs vol. 21 , ( 5 ) 657 - 666 .
Nicolaou M, Andress EJ, Zolnerciks JK, Dixon PH, Williamson C, Linton KJ ( 2012 ) . Canalicular ABC transporters and liver disease . J Pathol vol. 226 , ( 2 ) 300 - 315 .
Groen A, Romero MR, Kunne C, Hoosdally SJ, Dixon PH, Wooding C, Williamson C, Seppen J et al. ( 2011 ) . Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity . Gastroenterology vol. 141 , ( 5 )
Zolnerciks JK, Andress EJ, Nicolaou M, Linton KJ ( 2011 ) . Structure of ABC transporters . Essays Biochem vol. 50 , ( 1 ) 43 - 61 .
Linton KJ, Zolnerciks JK, Schmitt L ( 2011 ) . General Introduction, Structure and Likely Mechanism of Action of ABC Transport Proteins . The ABC Transporters of Human Physiology and Disease: Genetics and Biochemistry of ATP Binding Cassette Transporters , Editors: Linton, KJ, Holland, IB , World Scientific Publishing
Linton KJ, Holland IB ( 2011 ) . Preface .
Linton KJ, Holland IB ( 2011 ) . The ABC transporters of human physiology and disease: Genetics and biochemistry of atp binding cassette transporters .
Hoosdally SJ, Andress EJ, Wooding C, Martin CA, Linton KJ ( 2009 ) . The Human Scavenger Receptor CD36 GLYCOSYLATION STATUS AND ITS ROLE IN TRAFFICKING AND FUNCTION . J BIOL CHEM vol. 284 , ( 24 ) 16277 - 16288 .
Dixon PH, van Mil SWC, Chambers J, Strautnieks S, Thompson RJ, Lammert F, Kubitz R, Keitel V et al. ( 2009 ) . Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy . GUT vol. 58 , ( 4 ) 537 - 544 .
Byrne JA, Strautnieks SS, Ihrke G, Pagani F, Kinsely AS, Linton KJ, Mieli-Vergani G, Thompson RJ ( 2009 ) . Missense Mutations and Single Nucleotide Polymorphisms in ABCB11 Impair Bile Salt Export Pump Processing and Function or Disrupt Pre-Messenger RNA Splicing . HEPATOLOGY vol. 49 , ( 2 ) 553 - 567 .
Zolnerciks JK, Wooding C, Linton KJ ( 2007 ) . Evidence for a Sav1866-like architecture for the human multidrug transporter P-glycoprotein . FASEB J vol. 21 , ( 14 ) 3937 - 3948 .
Martin CA, Longman E, Wooding C, Hoosdally SJ, Ali S, Aitman TJ, Gutmann DAP, Freemont PS et al. ( 2007 ) . Cd36, a class B scavenger receptor, functions as a monomer to bind acetylated and oxidized low-density lipoproteins . PROTEIN SCI vol. 16 , ( 11 ) 2531 - 2541 .
Linton KJ ( 2007 ) . Structure and function of ABC transporters . PHYSIOLOGY vol. 22 , 122 - 130 .
Linton KJ, Higgins CF ( 2007 ) . Structure and function of ABC transporters: the ATP switch provides flexible control . PFLUG ARCH EUR J PHY vol. 453 , ( 5 ) 555 - 567 .
Byrne JA, Strautnieks SS, Ihrke G, Knisley AS, Jankowska I, Pawlowska J, Linton KJ, Higgins CF et al. ( 2005 ) . Investigation of MRNA splicing associated with the common BSEP mutations: An important disease mechanism for D482 . HEPATOLOGY . vol. 42 , 518A - 519A .
Elliott JI, Surprenant A, Marelli-Berg FM, Cooper JC, Cassady-Cain RL, Wooding C, Linton KJ, Alexander DR et al. ( 2005 ) . Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes . Nat. Cell Biol. vol. 7 , 808 - 816 .
Lepretre F, Linton KJ, Lacquemant C, Vatin V, Samson C, Dina C, Chikri M, Ali S et al. ( 2004 ) . Genetic study of the CD36 gene In a French diabetic population . DIABETES METAB vol. 30 , ( 5 ) 459 - 463 .
Higgins CF, Linton KJ ( 2004 ) . The ATP switch model for ABC transporters . NAT STRUCT MOL BIOL vol. 11 , ( 10 ) 918 - 926 .
Rothnie A, Storm J, Campbell J, Linton KJ, Kerr ID, Callaghan R ( 2004 ) . The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein . J BIOL CHEM vol. 279 , ( 33 ) 34913 - 34921 .
Lepretre F, Vasseur F, Vaxillaire M, Scherer PE, Ali S, Linton KJ, Aitman T, Froguel P ( 2004 ) . A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes . Hum Mutat vol. 24 , 104 - 110 .
Kerr ID, Berridge G, Linton KJ, Higgins CF, Callaghan R ( 2003 ) . Definition of the domain boundaries is critical to the expression of the nucleotide-binding domains of P-glycoprotein . EUR BIOPHYS J BIOPHY vol. 32 , ( 7 ) 644 - 654 .
Jodoin J, Demeule M, Fenart L, Cecchelli R, Farmer S, Linton KJ, Higgins CF, Beliveau R ( 2003 ) . P-glycoprotein in blood-brain barrier endothelial cells: interaction and oligomerization with caveolins . J NEUROCHEM vol. 87 , ( 4 ) 1010 - 1023 .
Stenham DR, Campbell JD, Sansom MSP, Higgins CF, Kerr ID, Linton KJ ( 2003 ) . An atomic detail model for the human ATP binding cassette transporter P-glycoprotein derived from disulphide cross-linking and homology modeling . FASEB J vol. 17 , ( 13 ) 2287 - + .
Gabriel MP, Storm J, Rothnie A, Taylor AM, Linton KJ, Kerr ID, Callaghan R ( 2003 ) . Communication between the nucleotide binding domains of P-glycoprotein occurs via conformational changes that involve residue 508 . BIOCHEMISTRY-US vol. 42 , ( 25 ) 7780 - 7789 .
Mullenbach R, Linton KJ, Wiltshire S, Weerasekera N, Chambers J, Elias E, Higgins CF, Johnston DG et al. ( 2003 ) . ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy . J MED GENET vol. 40 , ( 5 ) Article e70 ,
Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ ( 2003 ) . Characterisation of substrate specificity and identification of inhibitors of the human bile salt export pump, BSEP . GUT . vol. 52 ,
Mullenbach R, Linton KJ, Wiltshire S, Elias E, McCarthy MI, Williamson C ( 2003 ) . ABCB4 sequence variation in women with intrahepatic cholestasis of pregnancy . JOURNAL OF HEPATOLOGY . vol. 38 , 213 - 213 .
Byrne JA, Strautnieks SS, Higgins CF, Linton KJ, Thompson RJ ( 2003 ) . Function of BSEP . BILE ACIDS: FROM GENOMICS TO DISEASE AND THERAPY . Editors: Paumgartner, G, Keppler, D, Leuschner, U, Stiehl, A et al. , vol. 129 , 99 - 103 .
Byrne JA, Strautniks SS, Higgins CF, Linton KJ, Thompson RJ ( 2003 ) . Function of BSEP . Editors: Paumgartner, G , Springer
Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ ( 2002 ) . The human bile salt export pump: Characterization of substrate specificity and identification of inhibitors . GASTROENTEROLOGY vol. 123 , ( 5 ) 1649 - 1658 .
Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ ( 2002 ) . In vitro characterisation of the human bile salt export pump, BSEP . HEPATOLOGY . vol. 36 , 218A - 218A .
Higgins CF, Linton KJ ( 2002 ) . ABC transporters: An introduction and overview . ABC Proteins , Editors: Holland, IB, Cole, SPC, Kuchler, K, Higgins, CF et al. , Academic Press
Linton KJ, Higgins CF ( 2002 ) . P-glycoprotein misfolds in Escherichia coli: evidence against alternating-topology models of the transport cycle . MOL MEMBR BIOL vol. 19 , ( 1 ) 51 - 58 .
Linton KJ, Rosenberg M, Kerr ID, Higgins CF ( 2002 ) . Structure of ABC transporters . ABC Proteins , Editors: Holland, IB, Cole, SPC, Kuchler, K, Higgins, CF et al. , Academic Press
Taylor AM, Storm J, Soceneantu L, Linton KJ, Gabriel M, Martin C, Woodhouse J, Blott E et al. ( 2001 ) . Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein . BRIT J PHARMACOL vol. 134 , ( 8 ) 1609 - 1618 .
Rosenberg MF, Velarde G, Ford RC, Martin C, Berridge G, Kerr ID, Callaghan R, Schmidlin A et al. ( 2001 ) . Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle . EMBO J vol. 20 , ( 20 ) 5615 - 5625 .
Higgins CF, Linton KJ ( 2001 ) . Structural biology - The xyz of ABC transporters . SCIENCE vol. 293 , ( 5536 ) 1782 - 1784 .
Higgins CF, Linton KJ ( 2001 ) . The xyz of ABC transporters . Science vol. 293 , ( 5536 ) 1782 - 1784 .
Higgins CF, Callaghan R, Linton K, Ford R, Rosenberg M ( 2001 ) . Structure and function of the multidrug resistance P-glycoprotein . JOURNAL OF PHYSIOLOGY-LONDON . vol. 535 , 2S - 2S .
Dixon PH, Weerasekera N, Linton KJ, Donaldson O, Chambers J, Egginton E, Weaver J, Nelson-Piercy C et al. ( 2000 ) . Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking . HUM MOL GENET vol. 9 , ( 8 ) 1209 - 1217 .
Blott EJ, Higgins CF, Linton KJ ( 1999 ) . Cysteine-scanning mutagenesis provides no evidence for the extracellular accessibility of the nucleotide-binding domains of the multidrug resistance transporter P-glycoprotein . EMBO J vol. 18 , ( 23 ) 6800 - 6808 .
Higgins CF, Weylandt KH, Nastrucci C, Sardini A, Linton K, Diaz M, Valverde MA ( 1999 ) . Cell swelling-activated chloride channels and their regulation by P-glycoprotein . Chloride Channels , Editors: Kozlowski, R , Isis Press
Linton KJ, Higgins CF ( 1998 ) . The Escherichia coli ATP-binding cassette (ABC) proteins . MOL MICROBIOL vol. 28 , ( 1 ) 5 - 13 .
Lewis HD, Floriano B, Linton KJ, White J, Bibb MJ, Hunter IS, Leadlay PF ( 1997 ) . Evidence for a novel mechanism of resistance to the polyether polyketide tetronasin . FASEB J . vol. 11 , A1032 - A1032 .
Higgins CF, Callaghan R, Linton KJ, Rosenberg MF, Ford RC ( 1997 ) . Structure of the multidrug resistance P-glycoprotein . SEMIN CANCER BIOL vol. 8 , ( 3 ) 135 - 142 .
LINTON KJ, JARVIS BW, HUTCHINSON CR ( 1995 ) . CLONING OF THE GENES ENCODING THYMIDINE DIPHOSPHOGLUCOSE 4,6-DEHYDRATASE AND THYMIDINE DIPHOSPHO-4-KETO-6-DEOXYGLUCOSE 3,5-EPIMERASE FROM THE ERYTHROMYCIN-PRODUCING SACCHAROPOLYSPORA-ERYTHRAEA . GENE vol. 153 , ( 1 ) 33 - 40 .
LINTON KJ, THAMCHAIPENET A, HUNTER IS ( 1994 ) . The impact of molecular genetics on understanding antibiotic biosynthesis: Design of new drugs . PREHRAMBENO-TEHNOLOSKA I BIOTEHNOLOSKA REVIJA . vol. 32 , 61 - 65 .
LINTON KJ, COOPER HN, HUNTER IS, LEADLAY PF ( 1994 ) . AN ABC-TRANSPORTER FROM STREPTOMYCES-LONGISPOROFLAVUS CONFERS RESISTANCE TO THE POLYETHER-IONOPHORE ANTIBIOTIC TETRONASIN . MOL MICROBIOL vol. 11 , ( 4 ) 777 - 785 .
LINTON KJ, HUNTER IS ( 1988 ) . CLONING OF DNA-SEQUENCES FROM STREPTOMYCES-LONGISPOROFLAVUS WHICH CONFER INCREASED RESISTANCE TO THE IONOPHORE ANTIBIOTIC TETRONASIN IN STREPTOMYCES-LIVIDANS . HEREDITY vol. 61 , 304 - 305 .