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Research

Publications: Dr Sarah Martin

Silva VL, Saxena J, Nicolini F, Hoare JI, Metcalf S, Martin SA, Lockley M ( 2021 ) . Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer . Cell Death and Disease vol. 12 , ( 4 )
Cucchi D, Gibson A, Martin SA ( 2021 ) . The emerging relationship between metabolism and DNA repair . Cell Cycle vol. 20 , ( 10 ) 943 - 959 .
Dell'Anno I, Martin SA, Barbarino M, Melani A, Silvestri R, Bottaro M, Paolicchi E, Corrado A et al. ( 2020 ) . Drug-repositioning screening identified fludarabine and risedronic acid as potential therapeutic compounds for malignant pleural mesothelioma . Invest New Drugs vol. 39 , ( 1 ) 1 - 14 .
Martin S ( 2019 ) . MLH1 deficiency leads to deregulated mitochondrial metabolism . Cell Death and Disease vol. 10 , 795 - 795 .
Szlosarek P, Khadeir R, Sheaff M, Locke M, Lau K, Wu B, Bomalaski J, Martin S et al. ( 2017 ) . MA 19.05 Pegylated Arginine Deiminase Potentiates PD-1/PD-L1 Immune Checkpoint Blockade in Malignant Mesothelioma . Journal of Thoracic Oncology . vol. 12 ,
Shailes H, Bridge G, Foxler D, Sharp TV, Silver A, Martin SA ( 2017 ) . Abstract A31: Targeting APC loss using synthetic lethality in Colorectal Cancer . a31 - a31 .
Shailes H, Bridge G, Foxler D, Sharp TV, Silver A, Martin SA ( 2017 ) . Targeting APC loss using synthetic lethality in Colorectal Cancer . MOLECULAR CANCER THERAPEUTICS . vol. 16 ,
Guillotin D, Austin P, Begum R, Freitas MO, Merve A, Brend T, Short S, Marino S et al. ( 2017 ) . Drug-repositioning screens identify triamterene as a selective drug for the treatment of DNA mismatch repair deficient cells . Clinical Cancer Research vol. 23 , ( 11 ) 2880 - 2890 .
Locke M, Ghazaly E, Freitas MO, Mitsinga M, Lattanzio L, Lo Nigro C, Nagano A, Wang J et al. ( 2016 ) . Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1 . Cell Reports vol. 16 , ( 6 ) 1604 - 1613 .
Szlosarek PW, Locke M, Ghazaly E, Lattanzio L, Lo Nigro C, Martin SA ( 2016 ) . Abstract 1050: Inhibition of the polyamine synthesis pathway is synthetically lethal with loss of argininosuccinate synthase 1 in cancer . pp. 1050 - 1050 .
Tookman L, Ashley B, Connell C, Bridge G, Ingemarsdotter C, Dowson S, Shibata A, Michelle L et al. ( 2016 ) . 570 RAD51 and BRCA2 enhance oncolytic adenovirus type 5 activity in ovarian cancer . European Journal of Cancer vol. 61 ,
Tookman L, Ashley B, Connell C, Bridge G, Ingemarsdotter C, Dowson S, Shibata A, Michelle L et al. ( 2016 ) . RAD51 and BRCA2 enhance oncolytic adenovirus type 5 activity in ovarian cancer . EUROPEAN JOURNAL OF CANCER . vol. 61 , S124 - S124 .
Begum R, Martin S ( 2016 ) . Targeting mismatch repair deficiency in endometrial cancer . EUROPEAN JOURNAL OF CANCER . vol. 61 , S76 - S77 .
Martin SA ( 2016 ) . The DNA mismatch repair pathway . DNA Repair in Cancer Therapy: Molecular Targets and Clinical Applications: Second Edition ,
GROSE RP, Dawkins JBN, Wang J, maniati, heward, koniali, kocher, martin et al. ( 2016 ) . Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma . Cancer Research
Rashid S, Bridge G, Yao Z, Szabadkai G, Martin SA ( 2016 ) . Targeting the mitochondria for the treatment of MLH1-deficient disease . Journal of Clinical Oncology . vol. 34 , e23182 - e23182 .
Begum R, Martin SA ( 2016 ) . Targeting Mismatch Repair defects: A novel strategy for personalized cancer treatment . DNA Repair vol. 38 , 135 - 139 .
Martin SA ( 2016 ) . Chapter 6 The DNA mismatch repair pathway . DNA Repair in Cancer Therapy ,
Tookman LA, Browne AK, Connell CM, Bridge G, Ingemarsdotter CK, Dowson S, Shibata A, Lockley M et al. ( 2016 ) . RAD51 and BRCA2 enhance oncolytic adenovirus type 5 activity in ovarian cancer . Molecular Cancer Research vol. 14 , ( 1 ) 44 - 55 .
Rashid S, Bridge G, Yao Z, Szabadkai G, Martin SA ( 2015 ) . Abstract 4713: Targeting the mitochondria for the treatment of MLH1-deficient disease . 4713 - 4713 .
Begum R, Martin SA ( 2015 ) . Targeting Mismatch Repair defects: A novel strategy for personalized cancer treatment . DNA Repair
Guillotin D, Martin SA ( 2014 ) . Exploiting DNA mismatch repair deficiency as a therapeutic strategy . Exp Cell Res vol. 329 , ( 1 ) 110 - 115 .
Stewart GD, O'Mahony FC, Laird A, Rashid S, Martin SA, Eory L, Lubbock ALR, Nanda J et al. ( 2014 ) . Carbonic anhydrase 9 expression increases with vascular endothelial growth factor-targeted therapy and is predictive of outcome in metastatic clear cell renal cancer . Eur Urol vol. 66 , ( 5 ) 956 - 963 .
Hewish M, Fontebasso Y, Martin SA, Elliott R, Perks KL, Konde A, Bajrami I, Weverwijk AV et al. ( 2014 ) . Abstract 2931: Cancer cells deficient in DNA mismatch repair (MMR) are selectively sensitive to inhibition of the DNA dependent protein kinase (DNA-PK) . 2931 - 2931 .
Bridge G, Rashid S, Martin SA ( 2014 ) . DNA mismatch repair and oxidative DNA damage: implications for cancer biology and treatment . Cancers (Basel) vol. 6 , ( 3 ) 1597 - 1614 .
Brierley DJ, Martin SA ( 2013 ) . Oxidative stress and the DNA mismatch repair pathway . Antioxid Redox Signal vol. 18 , ( 18 ) 2420 - 2428 .
Hewish M, Martin SA, Elliott R, Cunningham D, Lord CJ, Ashworth A ( 2013 ) . Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress . Br J Cancer vol. 108 , ( 4 ) 983 - 992 .
Martin SA, Hewish M, Sims D, Lord CJ, Ashworth A ( 2011 ) . Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair-deficient cancers . Cancer Res vol. 71 , ( 5 ) 1836 - 1848 .
MARTIN S ( 2011 ) . Mitochondrial DNA repair . DNA Repair - On the pathways to fixing DNA damage and errors , INTECH
Martin SA, Lord CJ, Ashworth A ( 2010 ) . Therapeutic targeting of the DNA mismatch repair pathway . Clin Cancer Res vol. 16 , ( 21 ) 5107 - 5113 .
Hewish M, Lord CJ, Martin SA, Cunningham D, Ashworth A ( 2010 ) . Mismatch repair deficient colorectal cancer in the era of personalized treatment . Nat Rev Clin Oncol vol. 7 , ( 4 ) 197 - 208 .
Martin SA, McCabe N, Mullarkey M, Cummins R, Burgess DJ, Nakabeppu Y, Oka S, Kay E et al. ( 2010 ) . DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1 . Cancer Cell vol. 17 , ( 3 ) 235 - 248 .
Martin SA, Hewish M, Lord CJ, Ashworth A ( 2010 ) . Genomic instability and the selection of treatments for cancer . J Pathol vol. 220 , ( 2 ) 281 - 289 .
Martin SA, McCarthy A, Barber LJ, Burgess DJ, Parry S, Lord CJ, Ashworth A ( 2009 ) . Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2 . EMBO Mol Med vol. 1 , ( 6-7 ) 323 - 337 .
Mendes-Pereira AM, Martin SA, Brough R, McCarthy A, Taylor JR, Kim J-S, Waldman T, Lord CJ et al. ( 2009 ) . Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors . EMBO Mol Med vol. 1 , ( 6-7 ) 315 - 322 .
Lord CJ, Martin SA, Ashworth A ( 2009 ) . RNA interference screening demystified . J Clin Pathol vol. 62 , ( 3 ) 195 - 200 .
Martin SA, Ouchi T ( 2008 ) . Cellular commitment to reentry into the cell cycle after stalled DNA is determined by site-specific phosphorylation of Chk1 and PTEN . Mol Cancer Ther vol. 7 , ( 8 ) 2509 - 2516 .
Martin SA, Lord CJ, Ashworth A ( 2008 ) . DNA repair deficiency as a therapeutic target in cancer . Curr Opin Genet Dev vol. 18 , ( 1 ) 80 - 86 .
Tawara H, Fujiuchi N, Sironi J, Martin S, Aglipay J, Ouchi M, Taga M, Chen P-L et al. ( 2008 ) . Loss of p53-regulatory protein IFI16 induces NBS1 leading to activation of p53-mediated checkpoint by phosphorylation of p53 SER37 . Front Biosci vol. 13 , 240 - 248 .
Aglipay JA, Martin SA, Tawara H, Lee SW, Ouchi T ( 2006 ) . ATM activation by ionizing radiation requires BRCA1-associated BAAT1 . J Biol Chem vol. 281 , ( 14 ) 9710 - 9718 .
Martin SA, Ouchi T ( 2005 ) . BRCA1 phosphorylation regulates caspase-3 activation in UV-induced apoptosis . Cancer Res vol. 65 , ( 23 ) 10657 - 10662 .
Martin SA, Caplice NC, Davey GC, Powell R ( 2003 ) . Identification of genes expressed in the liver of the Atlantic salmon (Salmo salar) . Marine Biotechnology : An Overview of Leading Field . Editors: ColliecJouault, S , 90 - 94 .
Martin SA, Caplice NC, Davey GC, Powell R ( 2002 ) . EST-based identification of genes expressed in the liver of adult Atlantic salmon (Salmo salar) . Biochem Biophys Res Commun vol. 293 , ( 1 ) 578 - 585 .
Davey GC, Caplice NC, Martin SA, Powell R ( 2001 ) . Erratum - A survey of genes in the Atlantic salmon (Salmo salar) as identified by expressed sequence tags (Gene (2001) 263 (121-130) PII: S0378111900005874) . Gene vol. 269 , ( 1-2 )
Davey GC, Caplice NC, Martin SA, Powell R ( 2001 ) . A survey of genes in the Atlantic salmon (Salmo salar) as identified by expressed sequence tags . Gene vol. 263 , ( 1-2 ) 121 - 130 .