Skip to main content
Research

Publications: Prof Andrew Tinker

Morera C, Kim J, Paredes-Redondo A, Nobles M, Rybin D, Moccia R, Kowala A, Meng J et al. ( 2022 ) . CRISPR-mediated correction of skeletal muscle Ca<sup>2+</sup> handling in a novel DMD patient-derived pluripotent stem cell model .
Christensen SL, Rasmussen RH, Cour SL, Ernstsen C, Hansen TF, Kogelman LJA, Lauritzen SP, Guzaite G et al. ( 2022 ) . Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models . Cephalalgia vol. 42 , ( 2 ) 93 - 107 .
Van Duijvenboden S, Ramírez J, Young WJ, Orini M, Mifsud B, Tinker A, Lambiase PD, Munroe PB ( 2021 ) . Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders . Human Molecular Genetics vol. 30 , ( 24 ) 2513 - 2523 .
Tinker A ( 2021 ) . Does knowledge of the mutation in hereditary long QT syndrome aid risk stratification? . European Heart Journal vol. 42 , ( 46 ) 4756 - 4758 .
Mistry A, Funge G, Sebastian S, Aziz Q, Solomou A, Vignola ML, Thong LC, Herincs M et al. ( 2021 ) . Acromegalic cardiomyopathy in pituitary-specific aryl hydrocarbon receptor interacting protein (Aip) gene knockout animals . Endocrine Abstracts .
Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Zaman N, Tsisanova E, Mastroianni G et al. ( 2021 ) . Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy . Cell and Tissue Research vol. 386 , ( 1 ) 79 - 98 .
Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2021 ) . Prediction of Coronary Artery Disease using Traditional and Genetic Risk Scores for Cardiovascular Risk Factors . GENETIC EPIDEMIOLOGY . vol. 45 , 783 - 783 .
Rathod VSHS, Harmer S, Royal A, Aziz Q, Lambiase P, Tinker A ( 2021 ) . B-PO02-015 ENHANCING MUTANT I KSCHANNEL ACTIVITY BY ALTERING ENDOGENOUS PIP2 LEVELS AND ITS INTERACTION WITH PKA SIGNALLING PATHWAY . Heart Rhythm vol. 18 , ( 8 )
van Duijvenboden S, Ramirez J, Orini M, Tinker A, Munroe P, Lambiase P ( 2021 ) . 85 Prognostic value of premature ventricular complexes during exercise stress testing in 56,000 individuals without known structural heart disease from UK biobank: is a single ectopic prognostic? . Heart . Conference: Cardiac rhythm management vol. 107 , a68 - a68 .
Young W, Warren H, Mook-Kanamori D, Ramirez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al. ( 2021 ) . BS8 Genetically-determined serum calcium levels influence markers of ventricular repolarisation: a mendelian randomisation study . Heart . Conference: Basic science vol. 107 , a159 - a160 .
Rathod V, Harmer S, Royal A, Aziz Q, Lambiase P, Tinker A ( 2021 ) . Enhancing mutant IKS channel activity by increasing endogenous PIP2 levels and its interaction with PKA signalling pathway . EP Europace vol. 23 , ( Supplement_3 )
Mensah-Kane J, Schmidt AF, Hingorani AD, Finan C, Chen Y, van Duijvenboden S, Orini M, Lambiase PD et al. ( 2021 ) . No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis . Frontiers in Genetics vol. 12 ,
Tinker A, Aziz Q, Li Y ( 2021 ) . ATP-Dependent K+ Channels . Encyclopedia of Molecular Pharmacology ,
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Jones AR, Lambiase PD, Munroe PB, Tinker A ( 2021 ) . Analysing electrocardiographic traits and predicting cardiac risk in UK biobank . JRSM Cardiovasc Dis vol. 10 ,
Cartwright JH, Aziz Q, Harmer SC, Thayyil S, Tinker A, Munroe PB ( 2021 ) . Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function . Human Molecular Genetics vol. 29 , ( 5 ) 1797 - 1807 .
Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, Van Duijvenboden S, Orini M, Tinker A, Van Heemst D et al. ( 2021 ) . Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank . Circulation: Genomic and Precision Medicine331 - 338 .
Li Y, Aziz Q, Tinker A ( 2021 ) . The Pharmacology of ATP-Sensitive K<sup>+</sup> Channels (K<inf>ATP</inf>) . vol. 267 , 357 - 378 .
Sebastian S, Nobles M, Tsisanova E, Ludwig A, Munroe PB, Tinker A ( 2021 ) . The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate . Physiological Genomics vol. 53 , ( 4 ) 150 - 159 .
Ntalla I, Weng LC, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD et al. ( 2020 ) . Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction . Nature Communications vol. 11 , ( 1 )
Ramírez J, Tinker A ( 2020 ) . Ventricular Restitution Predicts Paroxysmal Atrial Fibrillation in Horses . Function vol. 2 , ( 1 )
Young WJ, van Duijvenboden S, Ramírez J, Jones A, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs . Biomedical Signal Processing and Control vol. 64 ,
Young WJ, Srinivasan N, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . Comparisons of the Spatial QRS-T Angle with Intra-cardiac Markers of Depolarization and Repolarization . Computing in Cardiology . vol. 2020-September ,
Van Duijvenboden S, Ramirez J, Young WJ, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . Evaluating the Impact of Physiological Variability in Genome-Wide Association Studies of Resting Heart Rate . Computing in Cardiology . vol. 2020-September ,
Ramirez J, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Interaction between ECG and Genetic Markers of Coronary Artery Disease . Computing in Cardiology . Conference: CinC 2020 from: 13/09/2020 to: 16/09/2020 , vol. 2020-September ,
Ramirez J, Van Duijvenboden S, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Sex Differences in the Morphology of RR-Matched T-waves . Computing in Cardiology . vol. 2020-September ,
Young WJ, Ramirez J, Van Duijvenboden S, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice? . Computing in Cardiology . vol. 2020-September ,
Balestrini S, Mikati MA, Garcia-Roves RA, Carboni M, Hunanyan AS, Kherallah B, McLean M, Prange L et al. ( 2020 ) . Cardiac phenotype in ATP1A3-related syndromes: A multicentre cohort study . Neurology
Li Y, Aziz Q, Anderson N, Ojake L, Tinker A ( 2020 ) . Endothelial ATP-Sensitive Potassium Channel Protects Against the Development of Hypertension and Atherosclerosis . HypertensionHYPERTENSIONAHA12015 - HYPERTENSIONAHA12015 .
Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S et al. ( 2020 ) . Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia . Journal of Molecular Medicine
Villar D, Frost S, Deloukas P, Tinker A ( 2020 ) . The contribution of non-coding regulatory elements to cardiovascular disease . Open Biology vol. 10 , ( 7 ) 200088 - 200088 .
Aziz Q, Tinker A ( 2020 ) . The Pathophysiology of Cardiac Abnormalities in Cantu Syndrome: Perspective on "The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome" . Function vol. 1 , ( 1 ) zqaa005 - zqaa005 .
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB, Tinker A ( 2020 ) . Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval . American Journal of Human Genetics vol. 106 , ( 6 ) 764 - 778 .
Williams JL, Paudyal A, Awad S, Nicholson J, Grzesik D, Botta J, Meimaridou E, Maharaj AV et al. ( 2020 ) . Mylk3 null c57bl/6n mice develop cardiomyopathy, whereas nnt null c57bl/6j mice do not . Life Science Alliance vol. 3 , ( 4 )
Tinker A, Aziz Q, Li Y ( 2020 ) . ATP-Dependent K + Channels . Encyclopedia of Molecular Pharmacology ,
Aziz Q, Nobles M, Tinker A ( 2020 ) . Acute Isolation of Cells from Murine Sino-atrial Node . Bio Protoc vol. 10 , ( 1 )
Aziz Q, Nobles M, Tinker A ( 2020 ) . Whole-cell and Perforated Patch-clamp Recordings from Acutely-isolated Murine Sino-atrial Node Cells . Bio Protoc vol. 10 , ( 1 )
Van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A, Munroe PB, Lambiase PD ( 2020 ) . Genetic Basis and Prognostic Value of Exercise QT Dynamics . Circulation: Genomic and Precision Medicine231 - 239 .
Balestrini S, Mikati M, Garcia-Roves RA, Carboni M, Hunanyan A, Kherallah B, McLean M, Prange L et al. ( 2019 ) . Cardiac Phenotype In ATP1A3 Related-Syndromes: A Multicentre Study . EPILEPSIA . vol. 60 , 173 - 173 .
Ramírez J, van Duijvenboden S, Aung N, Laguna P, Pueyo E, Tinker A, Lambiase PD, Orini M et al. ( 2019 ) . Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics . Circulation: Arrhythmia and Electrophysiology vol. 12 , ( 10 ) e007549 - e007549 .
Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA et al. ( 2019 ) . Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages . Physiol Genomics vol. 51 , ( 8 ) 323 - 332 .
Finlay M, Bhar-Amato J, Ng K-E, Santos D, Orini M, Vyas V, Taggart P, Grace AA et al. ( 2019 ) . Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome . Am J Physiol Cell Physiol
Ramirez J, van Duijvenboden S, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al. ( 2019 ) . Identification of novel loci for heart rate response to exercise and recovery . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 27 , 135 - 135 .
Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM et al. ( 2019 ) . Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals . Journal of the American College of Cardiology vol. 73 , ( 24 ) 3118 - 3131 .
Ramirez J, van Duijvenboden S, Tinker A, Lambiase P, Orini M, Munroe PB ( 2019 ) . 21 The cardiovascular predictive value and genetic basis of T-wave morphology . Heart . vol. 105 ,
van Duijvenboden S, Ramirez J, Orini M, Tinker A, Munroe PB, Lambiase P ( 2019 ) . 22 Cardiac repolarization during exercise reveals independent prognostic information for cardiovascular risk prediction . Heart . vol. 105 ,
Honarbakhsh S, Hunter RJ, Finlay M, Ullah W, Keating E, Tinker A, Schilling RJ ( 2019 ) . Development, in vitro validation and human application of a novel method to identify arrhythmia mechanisms: The stochastic trajectory analysis of ranked signals mapping method . Journal of Cardiovascular Electrophysiology vol. 30 , ( 5 ) 691 - 701 .
Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM et al. ( 2019 ) . Loss-of-function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype . British Journal of Dermatology vol. 180 , ( 5 ) 1114 - 1122 .
Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM et al. ( 2019 ) . DSP mutations and arrhythmogenic cardiomyopathy . British Journal of Dermatology vol. 180 , ( 5 ) e157 - e157 .
Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM et al. ( 2019 ) . DSP 突变与致心律失常性心肌病 . British Journal of Dermatology vol. 180 , ( 5 ) e169 - e169 .
Zhou X, Bueno-Orovio A, Schilling RJ, Kirkby C, Denning C, Rajamohan D, Burrage K, Tinker A et al. ( 2019 ) . Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D . Front Physiol vol. 10 , 259 - 259 .
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M et al. ( 2019 ) . CRISPR/Cas9 genome editing in human pluripotent stem cell-cardiomyocytes provides a platform for modeling hypertrophic cardiomyopathy . HUMAN GENE THERAPY . vol. 30 , A5 - A5 .
Scott ES, Awford J, Hyde R, Hassan M, Hashmi L, Harmer S, Fischer P, Kellam B et al. ( 2019 ) . Using bioluminescent hiPSC reporter lines and high content screening to identify novel compounds for cardiomyocyte maturation . HUMAN GENE THERAPY . vol. 30 , A8 - A8 .
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M et al. ( 2018 ) . CRISPR/Cas9 gene editing in human pluripotent stem cell-cardiomyocytes provides a platform for modeling hypertrophic cardiomyopathy . HUMAN GENE THERAPY . vol. 29 , A93 - A94 .
Calmont A, Anderson N, Suntharalingham JP, Ang R, Tinker A, Scambler PJ ( 2018 ) . Defective vagal innervation in murine TBX1 mutant hearts . Journal of Cardiovascular Development and Disease vol. 5 , ( 4 )
Arcidiacono P, Webb CM, Brooke MA, Zhou H, Delaney PJ, Ng KE, Blaydon DC, Tinker A et al. ( 2018 ) . P63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response . Nature Communications vol. 9 , ( 1 )
Ramírez J, Duijvenboden SV, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al. ( 2018 ) . Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system . Nature Communications vol. 9 , ( 1 )
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M et al. ( 2018 ) . CRISPR/Cas9 editing in human pluripotent stemcell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy . European Heart Journal vol. 39 , ( 43 ) 3879 - 3892 .
Ang R, Mastitskaya S, Hosford PS, Basalay M, Specterman M, Aziz Q, Li Y, Orini M et al. ( 2018 ) . Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1) . Circ Arrhythm Electrophysiol vol. 11 , ( 10 ) e006740 - e006740 .
Bhar-Amato J, Finlay M, Santos D, Orini M, Chaubey S, Vyas V, Taggart P, Grace AA et al. ( 2018 ) . Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome . Circ Arrhythm Electrophysiol vol. 11 , ( 9 ) e006330 - e006330 .
Ramirez J, Van Duijvenboden S, Laguna P, Pueyo E, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2018 ) . Assessing a Warping Methodology for the Identification of Increased Cardiovascular Risk Based on the HR Profile Morphology . Computing in Cardiology . Conference: Computing in Cardiology ( Maastricht, The Netherlands ) from: 23/09/2018 to: 26/09/2018 , vol. 2018-September ,
Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ et al. ( 2018 ) . Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker . EUROPEAN HEART JOURNAL . vol. 39 , 1206 - 1206 .
Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ et al. ( 2018 ) . P5709Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker . European Heart Journal vol. 39 , ( suppl_1 )
Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J et al. ( 2018 ) . Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6 . Genome Biology vol. 19 , ( 1 )
Aziz Q, Finlay M, Montaigne D, Ojake L, Li Y, Anderson N, Ludwig A, Tinker A ( 2018 ) . ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia . Journal of Biological Chemistry vol. 293 , ( 23 ) 8912 - 8921 .
Hosford PS, Christie IN, Niranjan A, Aziz Q, Anderson N, Ang R, Lythgoe MF, Wells JA et al. ( 2018 ) . A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow . Journal of Cerebral Blood Flow and Metabolism
Nobles M, Montaigne D, Sebastian S, Birnbaumer L, Tinker A ( 2018 ) . Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K<sup>+</sup>currents in adult murine atria . American Journal of Physiology - Cell Physiology vol. 314 , ( 5 ) C616 - C626 .
Tinker A, Finlay M, Nobles M, Opel A ( 2018 ) . Erratum to “The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation” [Pharmacol. Res. 105 (2016) 54–61](S1043661815301791)(10.1016/j.phrs.2015.11.008) . Pharmacological Research vol. 129 ,
Rathod VS, Harmer SC, Salsbury GA, Bitner-Glindzicz M, Lambiase PD, Tinker A ( 2018 ) . P449The novel long QT syndrome type 1 mutation KCNQ1-p.Thr247dup causes severe channel dysfunction but retains preserved adrenergic regulation . EP Europace vol. 20 , ( suppl_1 ) i87 - i87 .
Lovering RC, Roncaglia P, Howe DG, Laulederkind SJF, Khodiyar VK, Berardini TZ, Tweedie S, Foulger RE et al. ( 2018 ) . Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology . Circ Genom Precis Med vol. 11 , ( 2 ) e001813 - e001813 .
Orini M, Tinker A, Munroe PB, Lambiase PD ( 2018 ) . Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort . PLoS One vol. 13 , ( 2 ) e0193039 - e0193039 .
Tinker A, Aziz Q, Li Y, Specterman M ( 2018 ) . ATP-sensitive potassium channels and their physiological and pathophysiological roles . Comprehensive Physiology vol. 8 , ( 4 ) 1463 - 1511 .
Aziz Q, Li Y, Tinker A ( 2018 ) . Endothelial biology and ATP-sensitive potassium channels . Channels (Austin, Tex.) vol. 12 , ( 1 ) 45 - 46 .
Munroe PB, Addison S, Abrams DJ, Sebire NJ, Cartwright J, Donaldson I, Cohen MM, Mein C et al. ( 2018 ) . Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths . Circulation. Genomic and precision medicine vol. 11 , ( 1 )
Aziz Q, Li Y, Tinker A ( 2018 ) . Potassium channels in the sinoatrial node and their role in heart rate control . Channels vol. 12 , ( 1 ) 356 - 366 .
Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR et al. ( 2017 ) . Ajmaline blocks I<inf>Na</inf> and I<inf>Kr</inf> without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters . Stem Cell Research vol. 25 , 233 - 244 .
TINKER A, Lane J D ( 2017 ) . Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology? . Frontiers in Physiology vol. 8 ,
Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV et al. ( 2017 ) . Mammalian γ2 AMPK regulates intrinsic heart rate . Nat Commun vol. 8 , ( 1 ) 1258 - 1258 .
Aziz Q, Li Y, Anderson N, Ojake L, Tsisanova E, Tinker A ( 2017 ) . Molecular and functional characterization of the endothelial ATP-sensitive potassium channel . Journal of Biological Chemistry vol. 292 , ( 43 ) 17587 - 17597 .
Royal AA, Tinker A, Harmer SC ( 2017 ) . Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking . PLoS One vol. 12 , ( 10 ) Article 0186293 , e0186293 - e0186293 .
Lane JD, Montaigne D, Tinker A ( 2017 ) . Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation . vol. 250 , is. 5 , pp. 471 - 481 . Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob java.io.Serializable ,
Orini M, Tinker A, Munroe PB, Lambiase PD ( 2017 ) . Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort . PLoS One vol. 12 , ( 9 ) e0183732 - e0183732 .
Tinker A ( 2017 ) . The mechanisms of ventricular arrhythmia in Chagas disease . International Journal of Cardiology vol. 240 , 372 - 373 .
Munroe PB, Tinker A ( 2017 ) . Heritability of resting heart rate and association with mortality in middle-aged and elderly twins . Heart vol. 104 , ( 1 ) 6 - 7 .
Finlay M, Harmer SC, Tinker A ( 2017 ) . The control of cardiac ventricular excitability by autonomic pathways . Pharmacology and Therapeutics vol. 174 , 97 - 111 .
Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S, Tinker A, McKay T et al. ( 2017 ) . Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells . Molecular and Cellular Endocrinology vol. 447 , 12 - 22 .
Cartwright J, Aziz Q, Harmer S, Tinker A, Munroe P ( 2017 ) . Functional Studies of TRPM7-a Candidate Gene for Stillbirth? . FASEB JOURNAL . Conference: EB vol. 31 ,
MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H, Cabrera CP ( 2017 ) . Discovery of novel heart rate-associated loci using the exome chip . Human Molecular Genetics
Champney F, Maddock LJ, Welford J, Kemp J, Allan V, Persidskikh Y, Orini M, Ang R et al. ( 2016 ) . ORAL ABSTRACTS (1) . EP Europace vol. 18 , ( suppl_2 ) ii4 - ii7 .
Mellor G, Orini M, Specterman MJ, Sawhney VS, Merghani A, Claridge S, Laksman Z, Gerull B et al. ( 2016 ) . YOUNG INVESTIGATORS COMPETITION1GENETIC ANALYSIS IN THE EVALUATION OF UNEXPLAINED CARDIAC ARREST: FROM THE CARDIAC ARREST SURVIVORS WITH PRESERVED EJECTION FRACTION REGISTRY (CASPER)2IN-VIVO WHOLE HEART CONTACT MAPPING DATA AND A SIMPLE MATHEMATICAL FRAMEWORK TO UNDERSTAND THE INTERACTIONS BETWEEN ACTIVATION AND REPOLARIZATION RESITUTION DYNAMICS IN THE INTACT HUMAN HEART3THE K(ATP) CHANNEL OPENER DIAZOXIDE REDUCES AUTOMATICITY IN AN IN VITRO ATRIAL CELL MODEL - POTENTIAL FOR K(ATP) CHANNELS AS A DRUG TARGET FOR ATRIAL ARRHYTHMIAS4LONG-TERM OUTCOMES AFTER CATHETER ABLATION OF VENTRICULAR TACHYCARDIA IN PATIENTS WITH STRUCTURAL HEART DISEASE: A MULTICENTRE UK STUDY5THE BURDEN OF ARRHYTHMIAS IN LIFE-LONG ENDURANCE ATHLETES6CARDIAC MAGNETIC RESONANCE IMAGING RISK STRATIFICATION USING MARKERS OF REGIONAL AND DIFFUSE FIBROSIS FOR IMPLANTABLE CARDIOVERTER DEFIBRILLATOR THERAPY: THE VALUE OF T1 MAPPING IN NON-ISCHEMIC PATIENTS . EP Europace vol. 18 , ( suppl 2 ) ii1 - ii3 .
MUNROE PB ( 2016 ) . Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension . Nature Genetics
Rodriguez B, Carusi A, Abi-Gerges N, Ariga R, Britton O, Bub G, Bueno-Orovio A, Burton RAB et al. ( 2016 ) . Human-based approaches to pharmacology and cardiology: An interdisciplinary and intersectorial workshop . Europace vol. 18 , ( 9 ) 1287 - 1298 .
Ang R, Abramowitz J, Birnbaumer L, Gourine AV, Tinker A ( 2016 ) . The role of Gα<inf>O</inf>-mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability . Physiological Reports vol. 4 , ( 15 )
Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P et al. ( 2016 ) . GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway . Cell Rep vol. 16 , ( 4 ) 1026 - 1038 .
Ang R, Abramowitz J, Birnbaumer L, Gourine AV, Tinker A ( 2016 ) . Loss of the inhibitory GalphaO protein in the rostral ventrolateral medulla of the brainstem leads to abnormalities in cardiovascular reflexes and altered ventricular excitablitiy . CARDIOVASCULAR RESEARCH . Conference: ESC meeting vol. 111 , S98 - S98 .
Zhou X, Harmer S, Bueno-Orovio A, Burrage K, Tinker A, Rodriguez B ( 2016 ) . 57-03: How Can a Gain-of-Function Mutation in KCNQ1 Lead to Action Potential Prolongation? . EP Europace vol. 18 , ( suppl_1 ) i167 - i167 .
Tinker A, Finlay M, Nobles M, Opel A ( 2016 ) . The contribution of pathways initiated via the G<inf>q\11</inf> G-protein family to atrial fibrillation . Pharmacological Research vol. 105 , 54 - 61 .
Harmer SC, Tinker A ( 2016 ) . The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes . Biol Chem vol. 397 , ( 7 ) 679 - 693 .
Richards DA, Fletcher SA, Nobles M, Kossen H, Tedaldi L, Chudasama V, Tinker A, Baker JR ( 2016 ) . Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines . Organic and Biomolecular Chemistry vol. 14 , ( 2 ) 455 - 459 .
Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, Trapp S, Tinker A et al. ( 2015 ) . Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve . Heart Rhythm vol. 12 , ( 11 ) 2285 - 2293 .
Munroe PB, Tinker A ( 2015 ) . Genome-wide association studies and contribution to cardiovascular physiology . Physiological Genomics vol. 47 , ( 9 ) 365 - 375 .
Fletcher SA, Sin PKB, Nobles M, Årstad E, Tinker A, Baker JR ( 2015 ) . A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging . Organic and Biomolecular Chemistry vol. 13 , ( 37 ) 9559 - 9563 .
Machhada A, Ang R, Ackland G, Ninkina N, Buchman V, Lythgoe MF, Trapp S, Tinker A et al. ( 2015 ) . Reduced activity of dorsal vagal preganglionic neurones associated with synuclein pathology predisposes the heart to ventricular arrhythmia . EUROPEAN HEART JOURNAL . vol. 36 , 215 - 215 .
Opel A, Nobles M, Montaigne D, Finlay M, Anderson N, Breckenridge R, Tinker A ( 2015 ) . Absence of the regulator of G-protein Signaling, RGS4, predisposes to atrial fibrillation and is associated with abnormal calcium handling . Journal of Biological Chemistry vol. 290 , ( 31 ) 19233 - 19244 .
Yeoh A, Finlay M, Anderson N, Harmer S, Tinker A ( 2015 ) . 162 Simultaneous measurement of calcium transients and electrical activity in murine cardiac tissue – a novel system for the study of cardiac arrhythmia . Heart . vol. 101 ,
Lambiase PD, Tinker A ( 2015 ) . Connexins in the heart . Cell and Tissue Research vol. 360 , ( 3 ) 675 - 684 .
Nessa A, Aziz QH, Thomas AM, Harmer SC, Tinker A, Hussain K ( 2015 ) . Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8 . Human Molecular Genetics vol. 24 , ( 18 ) 5142 - 5153 .
Notari M, Hu Y, Sutendra G, Dedeić Z, Lu M, Dupays L, Yavari A, Carr CA et al. ( 2015 ) . iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death . Proceedings of the National Academy of Sciences of the United States of America vol. 112 , ( 9 ) E973 - E981 .
Aziz Q, Li Y, Tinker A ( 2015 ) . ATP-sensitive potassium channels and vascular function . Channels vol. 9 , ( 1 ) 3 - 4 .
Lane JD, Abramowitz J, Birnbaumer L, Tinker A ( 2014 ) . 51Cardiac specific knockout of G-alpha-i2 in a murine model of heart failure . Europace vol. 16 Suppl 3 ,
Aziz Q, Thomas AM, Gomes J, Ang R, Sones WR, Li Y, Ng K-E, Gee L et al. ( 2014 ) . The ATP-sensitive potassium channel subunit, Kir6.1, in vascular smooth muscle plays a major role in blood pressure control . Hypertension vol. 64 , ( 3 ) 523 - 529 .
Harmer SC, Mohal JS, Royal AA, McKenna WJ, Lambiase PD, Tinker A ( 2014 ) . Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1 . Biochem J vol. 462 , ( 1 ) 133 - 142 .
Youziel J, Akhbar AR, Aziz Q, Smith MEB, Caddick S, Tinker A, Baker JR ( 2014 ) . Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents . ORGANIC & BIOMOLECULAR CHEMISTRY vol. 12 , ( 4 ) 557 - 560 .
Arya VB, Aziz Q, Nessa A, Tinker A, Hussain K ( 2014 ) . Congenital hyperinsulinism: clinical and molecular characterisation of compound heterozygous ABCC8 mutation responsive to Diazoxide therapy . Int J Pediatr Endocrinol vol. 2014 , ( 1 )
Tinker A, Aziz Q, Thomas A ( 2014 ) . The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system . Br J Pharmacol vol. 171 , ( 1 ) 12 - 23 .
Tinker A, Harmer SC ( 2013 ) . Potassium channels regulating the electrical activity of the heart . Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment , vol. 9780857299208 ,
Posokhova E, Ng D, Opel A, Masuho I, Tinker A, Biesecker LG, Wickman K, Martemyanov KA ( 2013 ) . Essential Role of the m(2)R-RGS6-I-KACh Pathway in Controlling Intrinsic Heart Rate Variability . PLOS ONE vol. 8 , ( 10 ) Article ARTN e76973 ,
Sebastian S, Ang R, Abramowitz J, Weinstein LS, Chen M, Ludwig A, Birnbaumer L, Tinker A ( 2013 ) . The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins . Am J Physiol Regul Integr Comp Physiol vol. 305 , ( 4 ) R435 - R442 .
Ang R, Birnbaumer L, Gourine AV, Tinker A ( 2013 ) . The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart . European Heart Journal vol. 34 , ( suppl_1 ) p5030 - p5030 .
Ang R, Birnbaumer L, Gourine AV, Tinker A ( 2013 ) . The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart . EUROPEAN HEART JOURNAL . vol. 34 , 928 - 928 .
Telezhkin V, Thomas AM, Harmer SC, Tinker A, Brown DA ( 2013 ) . A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P-2 . PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY vol. 465 , ( 7 ) 945 - 953 .
Ang R, Birnbaumer L, Gourine A, Tinker A ( 2013 ) . THE ROLE OF INHIBITORY G PROTEIN GALPHAO-MEDIATED SIGNALLING IN THE CENTRAL NERVOUS MECHANISMS CONTROLLING SYMPATHETIC OUTFLOW TO THE HEART . HEART . vol. 99 , A121 - A121 .
Schwarzer S, Mashanov GI, Molloy JE, Tinker A ( 2013 ) . Using total internal reflection fluorescence microscopy to observe ion channel trafficking and assembly . Methods Mol Biol vol. 998 , 201 - 208 .
Maden CH, Gomes J, Schwarz Q, Davidson K, Tinker A, Ruhrberg C ( 2012 ) . NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system . DEVELOPMENTAL BIOLOGY vol. 369 , ( 2 ) 277 - 285 .
Tinker A, Harmer SC ( 2012 ) . Potassium channels regulating the electrical activity of the heart . Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment , vol. 9781430236870 ,
Risebro CA, Petchey LK, Smart N, Gomes J, Clark J, Vieira JM, Yanni J, Dobrzynski H et al. ( 2012 ) . Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3 . Circ Res vol. 111 , ( 2 ) e19 - e31 .
Harmer SC, Mohal JS, Kemp D, Tinker A ( 2012 ) . Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel . Biochem J vol. 443 , ( 3 ) 635 - 642 .
Telezhkin V, Reilly JM, Thomas AM, Tinker A, Brown DA ( 2012 ) . Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding . JOURNAL OF BIOLOGICAL CHEMISTRY vol. 287 , ( 13 ) 10001 - 10012 .
Tinker A ( 2012 ) . The assembly and targeting of potassium channels . Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels ,
Ang R, Sebastian S, Ludwig A, Birnbaumer L, Tinker A ( 2012 ) . Mice with conditional knockout of Galphai2 in the cardiac pacemaker system exhibit tachycardia with loss of HF power on HRV analysis . CARDIOVASCULAR RESEARCH . vol. 93 , S20 - S20 .
Aziz Q, Khambra T, Sones W, Thomas AM, Kotlikoff M, Tinker A ( 2012 ) . Mouse model for the conditional deletion of the KATP channel subunit Kir6.1 in vascular smooth muscle . CARDIOVASCULAR RESEARCH . vol. 93 , S74 - S74 .
Harmer SC, Mohal JS, Kemp D, Tinker A ( 2012 ) . Rescue of long QT syndrome type 1 nonsense mutations by pharmacologically mediated readthrough . CARDIOVASCULAR RESEARCH . vol. 93 , S105 - S105 .
Thomas AM, Aziz Q, Khambra T, Tinker A ( 2012 ) . The KATP channel subunit, Kir6.2, is regulated by a Ca2+-dependent isoform of Protein Kinase C . CARDIOVASCULAR RESEARCH . vol. 93 , S65 - S65 .
Nobles M, Sebastian S, Tinker A ( 2012 ) . The role of RGS4 in the electrophysiology of atrial cardiac myocytes . CARDIOVASCULAR RESEARCH . vol. 93 , S64 - S64 .
Aziz Q, Thomas AM, Khambra T, Tinker A ( 2012 ) . Regulation of the ATP-sensitive potassium channel subunit, Kir6.2, by a Ca2+-dependent protein kinase C . J Biol Chem vol. 287 , ( 9 ) 6196 - 6207 .
Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M et al. ( 2012 ) . Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study . Eur Heart Journal vol. 33 , ( 15 ) 1942 - 1953 .
Ang R, Opel A, Tinker A ( 2012 ) . The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias . Front Physiol vol. 3 ,
Hothersall JD, Black J, Caddick S, Vinter JG, Tinker A, Baker JR ( 2011 ) . The design, synthesis and pharmacological characterization of novel β <inf>2</inf>-adrenoceptor antagonists . British Journal of Pharmacology vol. 164 , ( 2 ) 317 - 331 .
Bollini S, Pozzobon M, Nobles M, Riegler J, Dong X, Piccoli M, Chiavegato A, Price AN et al. ( 2011 ) . In Vitro and In Vivo Cardiomyogenic Differentiation of Amniotic Fluid Stem Cells . Stem Cell Reviews and Reports vol. 7 , ( 2 ) 364 - 380 .
Schumacher FF, Nobles M, Ryan CP, Smith MEB, Tinker A, Caddick S, Baker JR ( 2011 ) . In situ maleimide bridging of disulfides and a new approach to protein PEGylation . Bioconjugate Chemistry vol. 22 , ( 2 ) 132 - 136 .
Voitychuk OI, Strutynskyi RB, Yagupolskii LM, Tinker A, Moibenko OO, Shuba YM ( 2011 ) . Sarcolemmal cardiac K <inf>ATP</inf> channels as a target for the cardioprotective effects of the fluorine-containing pinacidil analogue, flocalin . British Journal of Pharmacology vol. 162 , ( 3 ) 701 - 711 .
Thomas AM, Harmer SC, Khambra T, Tinker A ( 2011 ) . Characterization of a binding site for anionic phospholipids on KCNQ1 . Journal of Biological Chemistry vol. 286 , 2088 - 2100 .
Kapoor RR, Flanagan SE, James CT, McKiernan J, Thomas AM, Harmer SC, Shield JP, Tinker A et al. ( 2011 ) . Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations . Diab tologia vol. 54 , 2575 - 2583 .
Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, Segal AW ( 2010 ) . Erratum: The large-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channel is essential for innate immunity (Nature (2004) 427 (853-858)) . Nature vol. 468 , ( 7320 )
Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A, Caddick S ( 2010 ) . ChemInform Abstract: An Efficient Asymmetric Synthesis of the Potent β‐Blocker ICI‐118,551 Allows the Determination of Enantiomer Dependency on Biological Activity . ChemInform vol. 41 , ( 43 ) no - no .
Schwarzer S, Nobles M, Tinker A ( 2010 ) . Do caveolae have a role in the fidelity and dynamics of receptor activation of G-protein-gated inwardly rectifying potassium channels? . Journal of Biological Chemistry vol. 285 , ( 36 ) 27817 - 27826 .
Zuberi Z, Nobles M, Sebastian S, Dyson A, Lim SY, Breckenridge R, Birnbaumer L, Tinker A ( 2010 ) . Absence of the inhibitory g-protein gα<inf>i2</inf> predisposes to ventricular cardiac arrhythmia . Circulation: Arrhythmia and Electrophysiology vol. 3 , ( 4 ) 391 - 400 .
Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A, Caddick S ( 2010 ) . An efficient asymmetric synthesis of the potent β-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity . Chemical Communications vol. 46 , ( 22 ) 3953 - 3954 .
Nobles M, Sebastian S, Tinker A ( 2010 ) . HL-1 cells express an inwardly rectifying K<sup>+</sup> current activated via muscarinic receptors comparable to that in mouse atrial myocytes . Pflugers Archiv European Journal of Physiology vol. 460 , ( 1 ) 99 - 108 .
Aziz Q, Thomas A, Khambra T, Tinker A ( 2010 ) . Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel . European Journal of Pharmacology vol. 634 , ( 1-3 ) 26 - 32 .
Ng KE, Schwarzer S, Duchen MR, Tinker A ( 2010 ) . The intracellular localization and function of the ATP-sensitive K <sup>+</sup> channel subunit Kir6.1 . Journal of Membrane Biology vol. 234 , ( 2 ) 137 - 147 .
Mashanov GI, Nobles M, Harmer SC, Molloy JE, Tinker A ( 2010 ) . Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior . Journal of Biological Chemistry vol. 285 , 3664 - 3675 .
Tinker A, Harmer SC ( 2010 ) . K+ channels in the heart: new insights and therapeutic implications . Expert Rev Clin Pharmacol vol. 3 , 305 - 319 .
Harmer SC, Wilson AJ, Aldridge R, Tinker A ( 2010 ) . Mechanisms of disease pathogenesis in long QT syndrome type 5 . Am J Physiol Cell Physiol vol. 298 , C263 - C273 .
Breckenridge RA, Zuberi Z, Gomes J, Orford R, Dupays L, Felkin LE, Clark JE, Magee AI et al. ( 2009 ) . Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice . Journal of Molecular and Cellular Cardiology vol. 47 , ( 1 ) 133 - 141 .
Orie NN, Thomas AM, Perrino BA, Tinker A, Clapp LH ( 2009 ) . Ca <sup>2+</sup>/calcineurin regulation of cloned vascular K <inf>ATP</inf> channels: Crosstalk with the protein kinase a pathway . British Journal of Pharmacology vol. 157 , ( 4 ) 554 - 564 .
Zuberi Z, Birnbaumer L, Tinker A ( 2008 ) . The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics . American Journal of Physiology - Regulatory Integrative and Comparative Physiology vol. 295 , ( 6 )
Farzaneh T, Tinker A ( 2008 ) . Differences in the mechanism of metabolic regulation of ATP-sensitive K<sup>+</sup> channels containing Kir6.1 and Kir6.2 subunits . Cardiovascular Research vol. 79 , ( 4 ) 621 - 631 .
Campanella M, Tan C, Abramov A, Tinker A, Duchen M ( 2008 ) . S12/4 Mitochondria as ATP consumers: the cell biology of the endogenous inhibitory protein, IF1 . Biochimica et Biophysica Acta (BBA) - Bioenergetics vol. 1777 ,
Breckenridge RA, Zuberi Z, Felkin L, Birks E, Barton P, Tinker A, Mohun T ( 2008 ) . 446 Overexpression of the transcription factor Hand1 causes sudden cardiac death in mice . European Journal of Heart Failure Supplements vol. 7 , ( S1 ) 109 - 109 .
Quinn KV, Behe P, Tinker A ( 2008 ) . Monitoring changes in membrane phosphatidylinositol 4,5-bisphosphate in living cells using a domain from the transcription factor tubby . Journal of Physiology vol. 586 , ( 12 ) 2855 - 2871 .
Thomas AM, Tinker A ( 2008 ) . Determination of phosphoinositide binding to K<sup>+</sup> channel subunits using a protein-lipid overlay assay . Methods in Molecular Biology vol. 491 , 103 - 111 .
Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, Abramov AR, TINKER A, Duchen MR ( 2008 ) . Regulation of mitochondrial structure and function by IF1, the endogenous inhibitor of the mitochondrial ATPase . Cell Metabolism vol. 8 , ( 1 ) 13 - 25 .
Hughes S, Marsh SJ, Tinker A, Brown DA ( 2007 ) . PIP<inf>2</inf>-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: Direct on-line assessment of PIP<inf>2</inf> depletion by Gq-coupled receptors in single living neurons . Pflugers Archiv European Journal of Physiology vol. 455 , ( 1 ) 115 - 124 .
Falcetti E, Flavell DM, Staels B, Tinker A, Haworth SG, Clapp LH ( 2007 ) . IP receptor-dependent activation of PPARγ by stable prostacyclin analogues . Biochemical and Biophysical Research Communications vol. 360 , ( 4 ) 821 - 827 .
Brown DA, Hughes SA, Marsh SJ, Tinker A ( 2007 ) . Regulation of M(Kv7.2/7.3) channels in neurons by PIP<inf>2</inf> and products of PIP<inf>2</inf> hydrolysis: Significance for receptor-mediated inhibition . Journal of Physiology . vol. 582 , 917 - 925 .
Muzyamba M, Farzaneh T, Behe P, Thomas A, Christesen HBT, Brusgaard K, Hussain K, Tinker A ( 2007 ) . Complex ABCC8 DNA variations in congenital hyperinsulinism: Lessons from functional studies . Clinical Endocrinology vol. 67 , ( 1 ) 115 - 124 .
Harmer SC, Tinker A ( 2007 ) . The role of abnormal trafficking of KCNE1 in long QT syndrome 5 . Biochemical Society Transactions vol. 35 , 1074 - 1076 .
Tennant BP, Cui Y, Tinker A, Clapp LH ( 2006 ) . Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: Evidence for a major role of Kir2.4 subunits . Journal of Membrane Biology vol. 213 , ( 1 ) 19 - 29 .
Kang Y, Ng B, Leung YM, He Y, Xie H, Lodwick D, Norman RI, Tinker A et al. ( 2006 ) . Syntaxin-1A actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac K<inf>ATP</inf> channel activation . Journal of Biological Chemistry vol. 281 , ( 28 ) 19019 - 19028 .
Thomas AM, Brown SG, Leaney JL, Tinker A ( 2006 ) . Differential phosphoinositide binding to components of the G protein-gated K<sup>+</sup> channel . Journal of Membrane Biology vol. 211 , ( 1 ) 43 - 53 .
Tinker A ( 2006 ) . The selective interactions and functions of regulators of G-protein signalling . Seminars in Cell and Developmental Biology vol. 17 , ( 3 ) 377 - 382 .
Nobles M, Benians A, Tinker A ( 2005 ) . Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells . Proceedings of the National Academy of Sciences of the United States of America vol. 102 , ( 51 ) 18706 - 18711 .
Brown SG, Thomas A, Dekker LV, Tinker A, Leaney JL ( 2005 ) . PKC-δ sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M<inf>3</inf> receptor activation in HEK-293 cells . American Journal of Physiology - Cell Physiology vol. 289 , ( 3 58-3 )
Wilson AJ, Quinn KV, Graves FM, Bitner-Glindzicz M, Tinker A ( 2005 ) . Abnormal KCNQ1 trafficking influences disease pathogenesis in hereditary long QT syndromes (LQT1) . Cardiovascular Research vol. 67 , ( 3 ) 476 - 486 .
Benians A, Nobles M, Hosny S, Tinker A ( 2005 ) . Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein: A novel explanation for the acceleration of signaling activation kinetics . Journal of Biological Chemistry vol. 280 , ( 14 ) 13383 - 13394 .
Morrissey A, Rosner E, Lanning J, Parachuru L, Dhar Chowdhury P, Han S, Lopez G, Tong XY et al. ( 2005 ) . Immunolocalization of K<inf>ATP</inf> channel subunits in mouse and rat cardiac myocytes and the coronary vasculature . BMC Physiology vol. 5 ,
Benians A, Nobles M, Tinker A ( 2004 ) . Participation of RGS8 in the ternary complex of agonist, receptor and G-protein . Biochemical Society Transactions . vol. 32 , 1045 - 1047 .
Leaney JL, Benians A, Brown S, Nobles M, Kelly D, Tinker A ( 2004 ) . Rapid desensitization of G protein-gated inwardly rectifying K<sup>+</sup> currents is determined by G protein cycle . American Journal of Physiology - Cell Physiology vol. 287 , ( 1 56-1 )
Quinn KV, Giblin JP, Tinker A ( 2004 ) . Multisite phosphorylation mechanism for protein kinase A activation of the smooth muscle ATP-sensitive K<sup>+</sup> channel . Circulation Research vol. 94 , ( 10 ) 1359 - 1366 .
Ahluwalia J, Tinker A, Clapp LH, Buchen MR, Abramov AY, Pope S, Nobles M, Segal AW ( 2004 ) . The large-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channel is essential for innate immunity . Nature vol. 427 , ( 6977 ) 853 - 858 .
Quinn KV, Cui Y, Giblin JP, Clapp LH, Tinker A ( 2003 ) . Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K<sup>+</sup> channels? . Circulation Research vol. 93 , ( 7 ) 646 - 655 .
Benians A, Leaney JL, Tinker A ( 2003 ) . Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K<sup>+</sup> channels . Proceedings of the National Academy of Sciences of the United States of America vol. 100 , ( 10 ) 6239 - 6244 .
Cui Y, Tinker A, Clapp LH ( 2003 ) . Different molecular sites of action for the K <inf>ATP</inf> channel inhibitors, PNU-99963 and PNU-37883A . British Journal of Pharmacology vol. 139 , ( 1 ) 122 - 128 .
Benians A, Leaney JL, Milligan G, Tinker A ( 2003 ) . The dynamics of formation and action of the ternary complex revealed in living cells using a G-protein-gated K<sup>+</sup> channel as a biosensor . Journal of Biological Chemistry vol. 278 , ( 12 ) 10851 - 10858 .
Giblin JP, Quinn K, Tinker A ( 2002 ) . The cytoplasmic C-terminus of the sulfonylurea receptor is important for K<inf>ATP</inf> channel function but is not key for complex assembly or trafficking . European Journal of Biochemistry vol. 269 , ( 21 ) 5303 - 5313 .
Lawrence KM, Chanalaris A, Scarabelli T, Hubank M, Pasini E, Townsend PA, Comini L, Ferrari R et al. ( 2002 ) . K<inf>ATP</inf> channel gene expression is induced by urocortin and mediates its cardioprotective effect . Circulation vol. 106 , ( 12 ) 1556 - 1562 .
Giblin JP, Cui Y, Clapp LH, Tinker A ( 2002 ) . Assembly limits the pharmacological complexity of ATP-sensitive potassium channels . Journal of Biological Chemistry vol. 277 , ( 16 ) 13717 - 13723 .
Leaney JL, Benians A, Graves FM, Tinker A ( 2002 ) . A novel strategy to engineer functional fluorescent inhibitory G-protein alpha subunits . The Journal of biological chemistry vol. 277 , ( 32 ) 28803 - 28809 .
Clapp LH, Finney P, Turcato S, Tran S, Rubin LJ, Tinker A ( 2002 ) . Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery . American Journal of Respiratory Cell and Molecular Biology vol. 26 , ( 2 ) 194 - 201 .
Cui Y, Tran S, Tinker A, Clapp LH ( 2002 ) . The molecular composition of K<inf>ATP</inf> channels in human pulmonary artery smooth muscle cells and their modulation by growth . American Journal of Respiratory Cell and Molecular Biology vol. 26 , ( 1 ) 135 - 143 .
Leaney JL, Dekker LV, Tinker A ( 2001 ) . Regulation of a G protein-gated inwardly rectifying K<sup>+</sup> channel by a Ca<sup>2+</sup> -independent protein kinase C . Journal of Physiology vol. 534 , ( 2 ) 367 - 379 .
Cui Y, Giblin JP, Clapp LH, Tinker A ( 2001 ) . A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits . Proceedings of the National Academy of Sciences of the United States of America vol. 98 , ( 2 ) 729 - 734 .
Huang L, Bitner-Glindzicz M, Tranebjærg L, Tinker A ( 2001 ) . A spectrum of functional effects for disease causing mutations in the Jervell and Lange-Nielsen syndrome . Cardiovascular Research vol. 51 , ( 4 ) 670 - 680 .
Graves FM, Tinker A ( 2000 ) . Functional expression of the pore forming subunit of the ATP-sensitive potassium channel in Saccharomyces cerevisiae . Biochemical and Biophysical Research Communications vol. 272 , ( 2 ) 403 - 409 .
Leaney JL, Tinker A ( 2000 ) . The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel . Proceedings of the National Academy of Sciences of the United States of America vol. 97 , ( 10 ) 5651 - 5656 .
Leaney JL, Milligan G, Tinker A ( 2000 ) . The G protein α subunit has a key role in determining the specificity of coupling to, but not the activation of, G protein-gated inwardly rectifying K<sup>+</sup> channels . Journal of Biological Chemistry vol. 275 , ( 2 ) 921 - 929 .
Tinker A, Jan LY ( 1999 ) . Chapter 9 The Assembly of Inwardly Rectifying Potassium Channels . Current Topics in Membranes and Transport vol. 46 , ( C ) 143 - 158 .
Giblin JP, Leaney JL, Tinker A ( 1999 ) . The molecular assembly of ATP-sensitive potassium channels. Determinants on the pore forming subunit . Journal of Biological Chemistry vol. 274 , ( 32 ) 22652 - 22659 .
Clapp LH, Tinker A ( 1998 ) . Potassium channels in the vasculature . Current Opinion in Nephrology and Hypertension vol. 7 , ( 1 ) 91 - 98 .
Welch W, Williams AJ, Tinker A, Mitchell KE, Deslongchamps P, Lamothe J, Gerzon K, Bidasee KR et al. ( 1997 ) . Structural components of ryanodine responsible for modulation of sarcoplasmic reticulum calcium channel function . Biochemistry vol. 36 , ( 10 ) 2939 - 2950 .
Tinker A, Jan YN, Jan LY ( 1996 ) . Regions responsible for the assembly of inwardly rectifying potassium channels . Cell vol. 87 , ( 5 ) 857 - 868 .
Tinker A, Sutko JL, Ruest L, Deslongchamps P, Welch W, Airey JA, Gerzon K, Bidasee KR et al. ( 1996 ) . Electrophysiological effects of ryanodine derivatives on the sheep cardiac sarcoplasmic reticulum calcium-release channel . Biophysical Journal vol. 70 , ( 5 ) 2110 - 2119 .
Tinker A, Williams AJ ( 1995 ) . Measuring the length of the pore of the sheep cardiac sarcoplasmic reticulum calcium-release channel using related trimethylammonium ions as molecular calipers . Biophysical Journal vol. 68 , ( 1 ) 111 - 120 .
Lindsay ARG, Tinker A, Willams AJ ( 1994 ) . How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca<sup>2+</sup>-release channel? . Journal of General Physiology vol. 104 , ( 3 ) 425 - 447 .
Tinker A, Williams AJ ( 1993 ) . Probing the structure of the conduction pathway of the sheep cardiac sarcoplasmic reticulum calcium-release channel with permeant and impermeant organic cations . Journal of General Physiology vol. 102 , ( 6 ) 1107 - 1129 .
Tinker A, Lindsay ARG, Williams AJ ( 1993 ) . Cation conduction in the calcium release channel of the cardiac sarcoplasmic reticulum under physiological and pathophysiological conditions . Cardiovascular Research vol. 27 , ( 10 ) 1820 - 1825 .
Tinker A, Williams AJ ( 1993 ) . Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel . Biophysical Journal vol. 65 , ( 2 ) 852 - 864 .
Tinker A, Williams AJ ( 1993 ) . Using large organic cations to probe the nature of ryanodine modification in the sheep cardiac sarcoplasmic reticulum calcium release channel . Biophysical Journal vol. 65 , ( 4 ) 1678 - 1683 .
Tinker A, Williams AJ ( 1992 ) . Divalent cation conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum . Journal of General Physiology vol. 100 , ( 3 ) 479 - 493 .
Tinker A, Lindsay ARG, Williams AJ ( 1992 ) . Block of the sheep cardiac sarcoplasmic reticulum Ca<sup>2+</sup>-release channel by tetra-alkyl ammonium cations . The Journal of Membrane Biology vol. 127 , ( 2 ) 149 - 159 .
Tinker A, Lindsay ARG, Williams AJ ( 1992 ) . A model for ionic conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum . Journal of General Physiology vol. 100 , ( 3 ) 495 - 517 .
Tinker A, Lindsay ARG, Williams AJ ( 1992 ) . A model for ionic conduction in the sheep cardiac ryanodine receptor-channel . Journal of Physiology . vol. 446 ,
Tinker A, Lindsay AR, Williams AJ ( 1992 ) . Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel . Biophysical Journal vol. 61 , ( 5 ) 1122 - 1132 .