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Research

Publications: Prof Tyson Sharp

O'Loughlin J, Hall RJ, Bhaker S, Portelli MA, Henry A, Pang V, Bates DO, Sharp TV et al. ( 2021 ) . Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity . ERJ Open Res vol. 7 , ( 1 )
Hall R, O'Loughlin J, Bhaker S, Portelli MA, Henry A, Pang V, Bates DO, Sharp T et al. ( 2020 ) . Extended Lifespan Bronchial Epithelial Cells Maintain Cellular Phenotype and Transcriptome Integrity . a2298 - a2298 .
Hewitson JP, Shah KM, Brown N, Grevitt P, Hain S, Newling K, Sharp TV, Kaye PM et al. ( 2019 ) . miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity . EMBO Reports vol. 20 , ( 4 )
O¿Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM et al. ( 2019 ) . Oncometabolite induced primary cilia loss in pheochromocytoma . Endocrine-Related Cancer vol. 26 , ( 1 ) 165 - 180 .
Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A et al. ( 2018 ) . A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia . EMBO Mol Med
Chakraborty C, Mitra S, Roychowdhury A, Samadder S, Dutta S, Roy A, Das P, Mandal RK et al. ( 2018 ) . Deregulation of LIMD1–VHL–HIF-1α–VEGF pathway is associated with different stages of cervical cancer . Biochemical Journal vol. 475 , ( 10 ) 1793 - 1806 .
Wang L, Howell MEA, McPeak B, Riggs K, Kohne C, Yohanon JU, Foxler DE, Sharp TV et al. ( 2018 ) . LIMD1 is induced by and required for LMP1 signaling, and protects EBV-transformed cells from DNA damage-induced cell death . Oncotarget vol. 9 , ( 5 ) 6282 - 6297 .
Yee D, Shah KM, Coles MC, Sharp TV, Lagos D ( 2017 ) . MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells . J Biol Chem vol. 292 , ( 50 ) 20683 - 20693 .
Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR et al. ( 2017 ) . Ajmaline blocks I<inf>Na</inf> and I<inf>Kr</inf> without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters . Stem Cell Research vol. 25 , 233 - 244 .
Sur S, Maurya AK, Roy A, Sharp TV, Pal DK, Panda CK ( 2017 ) . Over expression of HIF1α is associated with inactivation of both LimD1 and VHL in renal cell carcinoma: Clinical importance . Pathology Research and Practice vol. 213 , ( 12 ) 1477 - 1481 .
Shailes H, Bridge G, Foxler D, Sharp TV, Silver A, Martin SA ( 2017 ) . Abstract A31: Targeting APC loss using synthetic lethality in Colorectal Cancer . a31 - a31 .
Shailes H, Bridge G, Foxler D, Sharp TV, Silver A, Martin SA ( 2017 ) . Targeting APC loss using synthetic lethality in Colorectal Cancer . MOLECULAR CANCER THERAPEUTICS . vol. 16 ,
Bridge KS, Shah KM, Li Y, Foxler DE, Wong SCK, Miller DC, Davidson KM, Foster JG et al. ( 2017 ) . Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins . Cell Reports vol. 20 , ( 1 ) 173 - 187 .
Dermit M, Casado P, Rajeeve V, Wilkes EH, Foxler DE, Campbell H, Critchlow S, Sharp TV et al. ( 2016 ) . Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition . Oncogene
Munye MM, Shoemark A, Hirst RA, Delhove JM, Sharp TV, McKay TR, O¿Callaghan C, Baines DL et al. ( 2016 ) . BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity . American Journal of Physiology - Lung Cellular and Molecular Physiology vol. 312 , ( 2 ) L258 - L267 .
Torr E, Heath M, Mee M, Shaw D, Sharp TV, Sayers I ( 2016 ) . Expression of polycomb protein BMI-1 maintains the plasticity of basal bronchial epithelial cells . Physiological Reports vol. 4 , ( 16 )
Warner MJ, Bridge KS, Hewitson JP, Hodgkinson MR, Heyam A, Massa BC, Haslam JC, Chatzifrangkeskou M et al. ( 2016 ) . S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells . Nucleic Acids Researchgkw631 - gkw631 .
Smith K, Sheaff M, Elia G, Clear A, Trevisan G, Foxler D, Bridge K, Shepherd S et al. ( 2016 ) . 888 Loss of LIM-domain proteins LIMD1, Ajuba and WTIP as a novel molecular mechanism for disease aetiology in clear cell renal cell carcinoma (ccRCC) . European Journal of Cancer vol. 61 ,
Feber A, Worth DC, Chakravarthy A, de Winter P, Shah K, Arya M, Saqib M, Nigam R et al. ( 2016 ) . CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma . Cancer Research vol. 76 , ( 16 ) 4720 - 4727 .
Leonov G, Shah K, Yee D, Timmis J, Sharp TV, Lagos D ( 2015 ) . Suppression of AGO2 by miR-132 as a determinant of miRNA-mediated silencing in human primary endothelial cells . International Journal of Biochemistry and Cell Biology vol. 69 , 75 - 84 .
Smith K, Sharp TV, Khetrapal P, Trevisian G ( 2014 ) . LIMD1 deregulation as a novel molecular mechanism for disease aetiology in clear cell Renal Cell Carcinoma (ccRCC) . VIRCHOWS ARCHIV . vol. 465 , S7 - S7 .
Foster JG, Wong SCK, Sharp TV ( 2014 ) . The hypoxic tumor microenvironment: Driving the tumorigenesis of non-small-cell lung cancer . Future Oncology vol. 10 , ( 16 ) 2659 - 2674 .
Hawkins KE, Sharp TV, McKay TR ( 2013 ) . The role of hypoxia in stem cell potency and differentiation . Regen Med vol. 8 , ( 6 ) 771 - 782 .
King MV, Kurian N, Qin S, Papadopoulou N, Westerink BHC, Cremers TI, Epping-Jordan MP, Le Poul E et al. ( 2013 ) . Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition . Neuropsychopharmacology vol. 39 , ( 2 ) 464 - 476 .
Sarkar S, Maiti GP, Jha J, Biswas J, Roy A, Roychoudhury S, Sharp T, Panda CK ( 2013 ) . Reduction of proliferation and induction of apoptosis are associated with shrinkage of head and neck squamous cell carcinoma due to neoadjuvant chemotherapy . Asian Pacific Journal of Cancer Prevention vol. 14 , ( 11 ) 6419 - 6425 .
Miliara S, Gkouskou KK, Sharp TV, Eliopoulos AG ( 2013 ) . SUMOylation is required for optimal TRAF3 signaling capacity . PLoS One vol. 8 , ( 11 )
Bridge KS, Sharp TV ( 2012 ) . Regulators of the hypoxic response: a growing family . FUTURE ONCOLOGY vol. 8 , ( 5 ) 491 - 493 .
Wong S, Longmore G, Sharp T ( 2012 ) . LIMD1 (LIM domains containing 1) . Atlas of Genetics and Cytogenetics in Oncology and Haematology ( 10 )
Foxler DE, Bridge KS, James V, Webb TM, Mee M, Wong SCK, Feng Y, Constantin-Teodosiu D et al. ( 2012 ) . The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity . Nat Cell Biol vol. 14 , ( 2 ) 201 - 208 .
James V, Wong SCK, Sharp TV ( 2012 ) . MicroRNA-mediated gene silencing: Are we close to a unifying model? . Biomolecular Concepts vol. 3 , ( 1 ) 29 - 40 .
Maiti GP, Ghosh A, Chatterjee R, Roy A, Sharp TV, Roychoudhury S, Panda CK ( 2012 ) . Reduced expression of LIMD1 in ulcerative oral epithelium associated with tobacco and areca nut . Asian Pac J Cancer Prev vol. 13 , ( 9 ) 4341 - 4346 .
González-Estévez C, Felix DA, Smith MD, Paps J, Morley SJ, James V, Sharp TV, Aboobaker AA ( 2012 ) . SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians . PLoS Genet vol. 8 , ( 3 )
McKay TR, Camarasa MV, Iskender B, Ye J, Bates N, Miller D, Fitzsimmons JC, Foxler D et al. ( 2011 ) . Human feeder cell line for derivation and culture of hESc/hiPSc . Stem Cell Res vol. 7 , ( 2 ) 154 - 162 .
Foxler DE, James V, Shelton SJ, Vallim TQDA, Shaw PE, Sharp TV ( 2011 ) . PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1 . FEBS Lett vol. 585 , ( 7 ) 1089 - 1096 .
Rothwell DG, Crossley R, Bridgeman JS, Sheard V, Zhang Y, Sharp TV, Hawkins RE, Gilham DE et al. ( 2010 ) . Functional expression of secreted proteins from a bicistronic retroviral cassette based on foot-and-mouth disease virus 2A can be position dependent . Hum Gene Ther vol. 21 , ( 11 ) 1631 - 1637 .
King MV, Kurian N, Smith M, Ray D, Fone KCF, Kendall DA, Marsden CA, Sharp TV ( 2010 ) . REVERSAL OF VESICULAR GLUTAMATE TRANSPORTER 1 (VGLUT1) LENTIVIRAL SHORT HAIRPIN RNA (SHRNA) VECTOR-INDUCED COGNITIVE DEFICITS BY A 5-HT6 RECEPTOR ANTAGONIST . JOURNAL OF PSYCHOPHARMACOLOGY . vol. 24 , A68 - A68 .
James V, Zhang Y, Foxler DE, de Moor CH, Kong YW, Webb TM, Self TJ, Feng Y et al. ( 2010 ) . LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing . Proc Natl Acad Sci U S A vol. 107 , ( 28 ) 12499 - 12504 .
Tsai Y-H, Wu M-F, Wu Y-H, Chang S-J, Lin S-F, Sharp TV, Wang H-W ( 2009 ) . The M type K15 protein of Kaposi's sarcoma-associated herpesvirus regulates microRNA expression via its SH2-binding motif to induce cell migration and invasion . J Virol vol. 83 , ( 2 ) 622 - 632 .
Sharp TV, Al-Attar A, Foxler DE, Ding L, de A Vallim TQ, Zhang Y, Nijmeh HS, Webb TM et al. ( 2008 ) . The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development . Proc Natl Acad Sci U S A vol. 105 , ( 50 ) 19932 - 19937 .
Spendlove I, Al-Attar A, Watherstone O, Webb TM, Ellis IO, Longmore GD, Sharp TV ( 2008 ) . Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival . Int J Cancer vol. 123 , ( 10 ) 2247 - 2253 .
Mckay TR, Sharp TV, Grady L, Camarasa M, Aplin J, Brison D, Kimber S ( 2008 ) . Genetically modified human placental fibroblasts as feeder cells for human embryonic stem cell derivation and culture . HUMAN GENE THERAPY . vol. 19 , 421 - 421 .
Sharp TV, Munoz F, Bourboulia D, Presneau N, Darai E, Wang H-W, Cannon M, Butcher DN et al. ( 2004 ) . LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription . Proc Natl Acad Sci U S A vol. 101 , ( 47 ) 16531 - 16536 .
Leonard P, Sharp T, Henderson S, Hewitt D, Pringle J, Sandison A, Goodship A, Whelan J et al. ( 2003 ) . Gene expression array profile of human osteosarcoma . British Journal of Cancer vol. 89 , ( 12 ) 2284 - 2288 .
Wang H-W, Sharp TV, Koumi A, Koentges G, Boshoff C ( 2002 ) . Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin . EMBO J vol. 21 , ( 11 ) 2602 - 2615 .
Sharp TV, Wang H-W, Koumi A, Hollyman D, Endo Y, Ye H, Du M-Q, Boshoff C ( 2002 ) . K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function . J Virol vol. 76 , ( 2 ) 802 - 816 .
Sharp TV, Boshoff C ( 2000 ) . Kaposi's sarcoma-associated herpesvirus: from cell biology to pathogenesis . IUBMB Life vol. 49 , ( 2 ) 97 - 104 .
Sharp TV, Raine DA, Gewert DR, Joshi B, Jagus R, Clemens MJ ( 1999 ) . Activation of the interferon-inducible (2'-5') oligoadenylate synthetase by the Epstein-Barr virus RNA, EBER-1 . Virology vol. 257 , ( 2 ) 303 - 313 .
Sharp TV, Moonan F, Romashko A, Joshi B, Barber GN, Jagus R ( 1998 ) . The vaccinia virus E3L gene product interacts with both the regulatory and the substrate binding regions of PKR: implications for PKR autoregulation . Virology vol. 250 , ( 2 ) 302 - 315 .
Sharp TV, Witzel JE, Jagus R ( 1997 ) . Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 (eIF2alpha) and the vaccinia virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase (PKR) . Eur J Biochem vol. 250 , ( 1 ) 85 - 91 .
Sharp TV, Xiao Q, Justesen J, Gewert DR, Clemens MJ ( 1995 ) . Regulation of the interferon-inducible protein kinase PKR and (2'-5')oligo(adenylate) synthetase by a catalytically inactive PKR mutant through competition for double-stranded RNA binding . Eur J Biochem vol. 230 , ( 1 ) 97 - 103 .
Xiao Q, Sharp TV, Jeffrey IW, James MC, Pruijn GJ, van Venrooij WJ, Clemens MJ ( 1994 ) . The La antigen inhibits the activation of the interferon-inducible protein kinase PKR by sequestering and unwinding double-stranded RNA . Nucleic Acids Res vol. 22 , ( 13 ) 2512 - 2518 .
Clemens MJ, Laing KG, Jeffrey IW, Schofield A, Sharp TV, Elia A, Matys V, James MC et al. ( 1994 ) . Regulation of the interferon-inducible eIF-2 alpha protein kinase by small RNAs . Biochimie vol. 76 , ( 8 ) 770 - 778 .
Sharp TV, Schwemmle M, Jeffrey I, Laing K, Mellor H, Proud CG, Hilse K, Clemens MJ ( 1993 ) . Comparative analysis of the regulation of the interferon-inducible protein kinase PKR by Epstein-Barr virus RNAs EBER-1 and EBER-2 and adenovirus VAI RNA . Nucleic Acids Res vol. 21 , ( 19 ) 4483 - 4490 .
Sharp TV, Xiao Q, Jeffrey I, Gewert DR, Clemens MJ ( 1993 ) . Reversal of the double-stranded-RNA-induced inhibition of protein synthesis by a catalytically inactive mutant of the protein kinase PKR . Eur J Biochem vol. 214 , ( 3 ) 945 - 948 .