Publications: Dr Michael Barnes

Leong IUS, Cabrera CP, Cipriani V, Ross PJ, Turner RM, Stuckey A, Sanghvi S, Pasko D et al. ( 2024 ) . Large-Scale Pharmacogenomics Analysis of Patients With Cancer Within the 100,000 Genomes Project Combining Whole-Genome Sequencing and Medical Records to Inform Clinical Practice . Journal of Clinical Oncology

Wenteler A, Cabrera CP, Wei W, Neduva V, Barnes MR ( 2024 ) . AI approaches for the discovery and validation of drug targets . Cambridge Prisms Precision Medicine vol. 2 ,

Henkin R, Goldmann K, Lewis M, Barnes MR ( 2024 ) . shinyExprPortal: a configurable ‘shiny’ portal for sharing analysis of molecular expression data . Bioinformatics vol. 40 , ( 4 )

Shoop-Worrall SJW, Lawson-Tovey S, Wedderburn LR, Hyrich KL, Geifman N, Consortium C, Kimonyo A, McNeece A et al. ( 2024 ) . Towards stratified treatment of JIA: machine learning identifies subtypes in response to methotrexate from four UK cohorts . EBioMedicine vol. 100 ,

Calero-Díaz H, Hamad RA, Atallah C, Casement J, Canoy D, Reynolds NJ, Barnes M, Missier P ( 2023 ) . Interpretable and robust hospital readmission predictions from Electronic Health Records . Conference: 2023 IEEE International Conference on Big Data (BigData) vol. 00 , 3679 - 3687 .

Goldmann K, Spiliopoulou A, Iakovliev A, Plant D, Nair N, Cubuk C, Consortium TM, McKeigue P et al. ( 2023 ) . Expression quantitative trait loci analysis in rheumatoid arthritis identifies tissue specific variants associated with severity and outcome . Annals of the Rheumatic Diseases vol. 83 , ( 3 ) 288 - 299 .

Eto F, Samuel M, Henkin R, Mahesh M, Ahmad T, Angdembe A, McAllister-Williams RH, Missier P et al. ( 2023 ) . Ethnic differences in early onset multimorbidity and associations with health service use, long-term prescribing, years of life lost, and mortality: A cross-sectional study using clustering in the UK Clinical Practice Research Datalink . PLOS Medicine vol. 20 , ( 10 )

Beesley R, Feilding FL, Beesley R, Douglas S, Earle E, Gannon N, Leslie K, MacDonald E et al. ( 2023 ) . Development and implementation of ‘A guide to PPIE – Early Integration into Research Proposals’ in a multi-disciplinary consortium . Rheumatology vol. 63 , ( 3 ) e88 - e91 .

Ng S, Masarone S, Watson D, Barnes MR ( 2023 ) . The benefits and pitfalls of machine learning for biomarker discovery . Cell and Tissue Research vol. 394 , ( 1 ) 17 - 31 .

Lawson-Tovey S, Smith SL, Geifman N, Shoop-Worrall S, Ng S, Barnes MR, Wedderburn LR, Hyrich KL ( 2023 ) . The successes and challenges of harmonising juvenile idiopathic arthritis (JIA) datasets to create a large-scale JIA data resource . Pediatric Rheumatology vol. 21 , ( 1 )

Lewis MJ, Spiliopoulou A, Goldmann K, Pitzalis C, McKeigue P, Barnes MR ( 2023 ) . nestedcv: an R package for fast implementation of nested cross-validation with embedded feature selection designed for transcriptomics and high-dimensional data . Bioinformatics Advances vol. 3 , ( 1 )

Voros S, Bansal AT, Barnes MR, Narula J, Maurovich-Horvat P, Vazquez G, Marvasty IB, Brown BO et al. ( 2023 ) . Bayesian network analysis of panomic biological big data identifies the importance of triglyceride-rich LDL in atherosclerosis development . Frontiers in Cardiovascular Medicine vol. 9 ,

Fernandes D, Khambata RS, Massimo G, Ruivo E, Gee LC, Foster J, Goddard A, Curtis M et al. ( 2022 ) . Local delivery of nitric oxide prevents endothelial dysfunction in periodontitis . Pharmacological Research vol. 188 ,

Kremer R, Raza SM, Eto F, Casement J, Atallah C, Finer S, Lendrem D, Barnes M et al. ( 2022 ) . Tracking trajectories of multiple long-term conditions using dynamic patient-cluster associations . Conference: 2022 IEEE International Conference on Big Data (Big Data) vol. 00 , 4390 - 4399 .

Boot J, Rosser G, Kancheva D, Vinel C, Lim YM, Pomella N, Zhang X, Guglielmi L et al. ( 2022 ) . Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape . eLife vol. 11 ,

Abdulkareem M, Kenawy AA, Rauseo E, Lee AM, Sojoudi A, Amir-Khalili A, Lekadir K, Young AA et al. ( 2022 ) . Predicting post-contrast information from contrast agent free cardiac MRI using machine learning: Challenges and methods . Frontiers in Cardiovascular Medicine vol. 9 ,

Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CM, Millar B, Maney NJ, Anderson AE et al. ( 2022 ) . Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming . Annals of the Rheumatic Diseases vol. 81 , ( 9 ) 1214 - 1223 .

Hunt GP, Grassi L, Henkin R, Smeraldi F, Spargo TP, Kabiljo R, Koks S, Ibrahim Z et al. ( 2022 ) . GEOexplorer: a webserver for gene expression analysis and visualisation . Nucleic Acids Research vol. 50 , ( W1 ) w367 - w374 .

Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A et al. ( 2022 ) . Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial . Nature Medicine vol. 28 , ( 6 ) 1256 - 1268 .

Isaacs JD, Brockbank S, Pedersen AW, Hilkens C, Anderson A, Stocks P, Lendrem D, Tarn J et al. ( 2022 ) . RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients . Scientific Data vol. 9 , ( 1 )

Tarn J, Lendrem D, Barnes M, Casement J, Ng W-F ( 2022 ) . Comorbidities in the UK Primary Sjögren’s Syndrome Registry . Frontiers in Immunology vol. 13 ,

Solanky S, Ejarque RA, Khan S, Tosi I, Dawe H, Dand N, Mahil S, Barnes MR et al. ( 2022 ) . IL-23-induced STAT3 translocation in MAIT cells at baseline is a candidate biomarker of response for biologics targeting the IL-23/IL-17 axis . BRITISH JOURNAL OF DERMATOLOGY . vol. 186 , E231 - E231 .

Solanky S, Ejarque RA, Tosi I, Dawe H, Dand N, Mahil S, Barnes MR, Griffiths CEM et al. ( 2022 ) . Interleukin-23-induced STAT3 translocation in circulating mucosal-associated invariant T cells is a potential biomarker of clinical response to ustekinumab in psoriasis . BRITISH JOURNAL OF DERMATOLOGY . vol. 186 , E45 - E45 .

Hardman-Smart JA, Ejarque RA, Solanky S, Tosi I, Grys K, Nichols E, Villanova F, Barnes MR et al. ( 2022 ) . Relative frequency of monocyte subsets at baseline in psoriasis is associated with clinical outcome to secukinumab therapy . BRITISH JOURNAL OF DERMATOLOGY . vol. 186 , E15 - E16 .

Saengkaew T, Ruiz-Babot G, David A, Mancini A, Mariniello K, Cabrera CP, Barnes MR, Dunkel L et al. ( 2021 ) . Whole exome sequencing identifies deleterious rare variants in CCDC141 in familial self-limited delayed puberty . npj Genomic Medicine vol. 6 , ( 1 )

Andres-Ejarque R, Ale HB, Grys K, Tosi I, Solanky S, Ainali C, Catak Z, Sreeneebus H et al. ( 2021 ) . Author Correction: Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis . Nature Communications vol. 12 , ( 1 )

Smedley D, Smith KR, Martin AR, Thomas EA, McDonagh EM, Cipriani V, Ellingford JM, Arno G et al. ( 2021 ) . 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care — Preliminary Report . New England Journal of Medicine vol. 385 , ( 20 ) 1868 - 1880 .

Barnes M, Brockbank S, Bruce IN, Ciurtin C, Cop AP, Ehrenstein MR, Emery P, Fisher BA et al. ( 2021 ) . Characterization of disease course and remission in early seropositive rheumatoid arthritis: results from the TACERA longitudinal cohort study . Therapeutic Advances in Musculoskeletal Disease vol. 13 ,

Andres-Ejarque R, Ale HB, Grys K, Tosi I, Solanky S, Ainali C, Catak Z, Sreeneebus H et al. ( 2021 ) . Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis . Nature Communications vol. 12 , ( 1 )

Geifman N, Azadbakht N, Zeng J, Wilkinson T, Dand N, Buchan I, Stocken D, Di Meglio P et al. ( 2021 ) . Defining trajectories of response in patients with psoriasis treated with biologic therapies . British Journal of Dermatology vol. 185 , ( 4 ) 825 - 835 .

Saengkaew T, Mancini A, Ruiz-Babot G, Cabrera CP, Barnes MR, Dunkel L, Guasti L, Howard S ( 2021 ) . Defects in the GnRH Neuronal Migration factor, CCDC141, Lead to Self-Limited Delayed Puberty . Journal of the Endocrine Society vol. 5 , ( Supplement_1 ) a665 - a666 .

Yiu ZZN, Barker JNWN, Barnes MR, Di Meglio P, Emsley R, Reynolds NJ, Smith CH, Warren RB et al. ( 2021 ) . Meeting Report: Psoriasis Stratification to Optimize Relevant Therapy Showcase . Journal of Investigative Dermatology vol. 141 , ( 8 ) 1872 - 1878 .

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2021 ) . Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals . Nature Genetics vol. 53 , ( 5 ) 762 - 762 .

Shoop-Worrall SJW, Hyrich KL, Wedderburn LR, Thomson W, Geifman N, Consortium CTC, Baildam E, Barnes M et al. ( 2020 ) . Patient-reported wellbeing and clinical disease measures over time captured by multivariate trajectories of disease activity in individuals with juvenile idiopathic arthritis in the UK: a multicentre prospective longitudinal study . The Lancet Rheumatology vol. 3 , ( 2 ) e111 - e121 .

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2020 ) . Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals . Nature Genetics vol. 52 , ( 12 ) 1314 - 1332 .

Aarum J, Cabrera CP, Jones TA, Rajendran S, Adiutori R, Giovannoni G, Barnes MR, Malaspina A et al. ( 2020 ) . Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates . EMBO Reports vol. 21 , ( 10 ) Article ARTN e49585 ,

Aarum J, Cabrera CP, Jones TA, Rajendran S, Adiutori R, Giovannoni G, Barnes MR, Malaspina A et al. ( 2020 ) . Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates . EMBO Reports vol. 21 , ( 10 )

Cherlin S, Lewis MJ, Plant D, Nair N, Goldmann K, Tzanis E, Barnes MR, McKeigue P et al. ( 2020 ) . Investigation of genetically regulated gene expression and response to treatment in rheumatoid arthritis highlights an association between IL18RAP expression and treatment response . Annals of the Rheumatic Diseases vol. 79 , ( 11 ) 1446 - 1452 .

Mancini A, Howard SR, Marelli F, Cabrera CP, Barnes MR, Sternberg MJE, Leprovots M, Hadjidemetriou I et al. ( 2020 ) . LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling . JCI Insight vol. 5 , ( 11 )

Ntalla I, Weng L-C, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD et al. ( 2020 ) . Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction . Nature Communications vol. 11 , ( 1 )

Nicholls HL, John CR, Watson DS, Munroe PB, Barnes MR, Cabrera CP ( 2020 ) . Reaching the End-Game for GWAS: Machine Learning Approaches for the Prioritization of Complex Disease Loci . Frontiers in Genetics vol. 11 ,

Loeff FC, Tsakok T, Dijk L, Hart MH, Duckworth M, Baudry D, Russell A, Dand N et al. ( 2020 ) . Clinical Impact of Antibodies against Ustekinumab in Psoriasis: An Observational, Cross-Sectional, Multicenter Study . Journal of Investigative Dermatology vol. 140 , ( 11 ) 2129 - 2137 .

Hemingway H, Lyons R, Li Q, Buchan I, Ainsworth J, Pell J, Morris A ( 2020 ) . A national initiative in data science for health: an evaluation of the UK Farr Institute . Int J Popul Data Sci vol. 5 , ( 1 ) 1128 - 1128 .

John CR, Watson D, Russ D, Goldmann K, Ehrenstein M, Pitzalis C, Lewis M, Barnes M ( 2020 ) . M3C: Monte Carlo reference-based consensus clustering . Scientific Reports vol. 10 , ( 1 )

Pan S, Tsakok T, Dand N, Lonsdale DO, Loeff FC, Bloem K, de Vries A, Baudry D et al. ( 2020 ) . Using Real‐World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic‐Pharmacodynamic Study . Clinical and Translational Science vol. 13 , ( 2 ) 400 - 409 .

Ricci B, Millner TO, Pomella N, Zhang X, Guglielmi L, Badodi S, Ceric D, Gemma C et al. ( 2020 ) . Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma . Oncogene . vol. 39 , 2523 - 2538 .

Cabrera CP, Pazoki R, Giri A, Hellwege JN, Evangelou E, Ramirez J, Wain LV, Tzoulaki I et al. ( 2020 ) . Multi-trait genome-wide association analysis of blood pressure identifies 45 additional loci . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 28 , 105 - 105 .

Smit RAJ, Trompet S, Leong A, Goodarzi MO, Postmus I, Warren H, Theusch E, Barnes MR et al. ( 2019 ) . Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study . Pharmacogenomics Journal

Tsakok T, Wilson N, Dand N, Loeff FC, Bloem K, Baudry D, Duckworth M, Pan S et al. ( 2019 ) . Association of Serum Ustekinumab Levels With Clinical Response in Psoriasis . JAMA Dermatology vol. 155 , ( 11 ) 1235 - 1243 .

Mancini A, Howard SR, Cabrera CP, Barnes MR, David A, Wehkalampi K, Vassert G, Cariboni A et al. ( 2019 ) . Defects in LGR4 Wnt-[beta]-catenin signalling impair GnRH network development, leading to delayed puberty . Endocrine Abstracts

Petersen S, Munroe P, Aung N, Fung K, Vargas J, Yang C, Cabrera CP, Warren H et al. ( 2019 ) . Genome-wide analysis of left ventricular image-derived phenotypes identifies fourteen loci associated with cardiac morphogenesis and heart failure development . Circulation

John CR, Watson D, Barnes MR, Pitzalis C, Lewis MJ ( 2019 ) . Spectrum: fast density-aware spectral clustering for single and multi-omic data . Bioinformatics vol. 36 , ( 4 ) 1159 - 1166 .

Caley M, Marsh S, Martins VL, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al. ( 2019 ) . 298 Defective DNA Repair and Chromosomal Instability in RDEB . Journal of Investigative Dermatology . vol. 139 ,

Lewis MJ, Barnes MR, Blighe K, Goldmann K, Rana S, Hackney JA, Ramamoorthi N, John CR et al. ( 2019 ) . Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes . Cell Reports vol. 28 , 2455 - 2470 .

Cabrera CP, Ng F, Nicholls HL, Gupta A, Barnes MR, Munroe PB, Caulfield MJ ( 2019 ) . Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated . Human Molecular Genetics vol. 28 , ( R2 ) R151 - R161 .

Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA et al. ( 2019 ) . Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages . Physiol Genomics vol. 51 , ( 8 ) 323 - 332 .

Aung N, Vargas JD, Manichaikul AW, Yang C, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . 199Genetic architecture of left ventricular phenotypes derived from 17,000 CMR studies in the UK Biobank population imaging cohort . European Heart Journal - Cardiovascular Imaging . vol. 20 ,

Aung N, Vargas JD, Manichaikul AW, Yang CP, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . P463Heritability and genotypic correlation of CMR-derived LV phenotypes in the UK Biobank population imaging study . European Heart Journal - Cardiovascular Imaging . vol. 20 ,

John CR, Watson D, Barnes M, Pitzalis C, Lewis MJ ( 2019 ) . Spectrum: Fast density-aware spectral clustering for single and multi-omic data .

Howard S, Cabrera C, Barnes M, Dunkel L ( 2019 ) . MON-LB048 Delayed or Absent? Use of Next Generation Sequencing Diagnostic Tools in a UK Puberty Cohort . Journal of the Endocrine Society vol. 3 , ( Supplement_1 ) mon - lb048 .

HUMBY F ( 2019 ) . Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients . Annals of the Rheumatic Diseases

Watson DS, Krutzinna J, Bruce IN, Griffiths CE, McInnes IB, Barnes MR, Floridi L ( 2019 ) . Clinical applications of machine learning algorithms: beyond the black box . The BMJ vol. 364 ,

Bodagh N, Archbold RA, Weerackody R, Hawking MKD, Barnes MR, Lee AM, Janjuha S, Gutteridge C et al. ( 2019 ) . Feasibility of real-time capture of routine clinical data in the electronic health record: a hospital-based, observational service-evaluation study . BMJ Open vol. 8 , ( 3 ) e019790 - e019790 .

Mancini A, Howard SR, Cabrera CP, Barnes MR, David A, Wehkalampi K, Heger S, Lomniczi A et al. ( 2019 ) . EAP1 regulation of GnRH promoter activity is important for human pubertal timing . Human Molecular Genetics vol. 28 , ( 8 ) 1357 - 1368 .

Foulkes AC, Watson DS, Carr DF, Kenny JG, Slidel T, Parslew R, Pirmohamed M, PSORT Consortium et al. ( 2019 ) . A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis . J Invest Dermatol vol. 139 , ( 1 ) 100 - 107 .

Aung N, Vargas JD, Manichaikul AW, Yang C, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . Genetic architecture of left ventricular phenotypes derived from 17,000 CMR studies in the UK Biobank population imaging cohort . EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING . vol. 20 , 155 - 156 .

Aung N, Vargas JD, Manichaikul AW, Yang CP, Cabrera CP, Warren HR, Fung K, Tzanis E et al. ( 2019 ) . Heritability and genotypic correlation of CMR-derived LV phenotypes in the UK Biobank population imaging study . EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING . vol. 20 , 377 - 378 .

Mancini A, Howard SR, Cabrera CP, Barnes MR, David A, Wehkalampi K, Vassart G, Cariboni A et al. ( 2019 ) . LGR 4-Wnt β-catenin signalling directs GnRH network development, with defects leading to self-limited delayed puberty . HORMONE RESEARCH IN PAEDIATRICS . vol. 91 , 46 - 46 .

CHAPPLE JP, O'TOOLE S, WATSON D, NOVOSELOVA T, ROMANO L, KING PJ, BRADSHAW T, THOMPSON CL et al. ( 2019 ) . Oncometabolite induced primary cilia loss in pheochromocytoma . Endocrine-Related Cancer

Dand N, Duckworth M, Baudry D, Russell A, Curtis CJ, Lee SH, Evans I, Mason KJ et al. ( 2018 ) . HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis . Journal of Allergy and Clinical Immunology vol. 143 , ( 6 ) 2120 - 2130 .

Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA et al. ( 2018 ) . The RA-MAP Consortium: a working model for academia-industry collaboration . Nat Rev Rheumatol vol. 14 , ( 1 ) 53 - 60 .

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al. ( 2018 ) . Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits . Nat Genet vol. 50 , ( 12 ) 1755 - 1755 .

Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al. ( 2018 ) . Correction: Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study . PLoS Med vol. 15 , ( 10 ) e1002694 - e1002694 .

Consortium R-M ( 2018 ) . Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data . RMD Open vol. 4 , ( 2 )

Costa ARD, Qarin S, Bradshaw T, Watson D, Prasad R, Metherell LA, Barnes MR, Skarnes W et al. ( 2018 ) . Can novel stem cell models help unpick the pathogenesis of the Triple A syndrome? . Endocrine Abstracts

Howard SR, Cabrera CP, Barnes MR, Dunkel L ( 2018 ) . Delayed or Absent? - use of next generation sequencing diagnostic tools in a UK puberty cohort . Endocrine Abstracts

Cherlin S, Plant D, Taylor JC, Colombo M, Spiliopoulou A, Tzanis E, Morgan AW, Barnes MR et al. ( 2018 ) . Prediction of treatment response in rheumatoid arthritis patients using genome‐wide SNP data . Genetic Epidemiology vol. 42 , ( 8 ) 754 - 771 .

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al. ( 2018 ) . Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits . Nature Genetics vol. 50 , ( 10 ) 1412 - 1425 .

Da Costa AR, Qarin S, Bradshaw TY, Watson D, Prasad R, Barnes MR, Metherell LA, Chapple JP et al. ( 2018 ) . A Novel Stem Cell Model for the Triple a Syndrome . HORMONE RESEARCH IN PAEDIATRICS . Conference: 57th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE) ( Athens, Greece ) from: 27/09/2018 to: 29/09/2018 , vol. 90 , 29 - 29 .

Tragante V, Hemerich D, Alshabeeb M, Brænne I, Lempiäinen H, Patel RS, den Ruijter HM, Barnes MR et al. ( 2018 ) . Druggability of Coronary Artery Disease Risk Loci . Circ Genom Precis Med vol. 11 , ( 8 ) e001977 - e001977 .

Jones TF, Torrance HDT, Owen HC, Brohi K, Barnes MR, Knight JC, Hinds CJ, Ackland GL et al. ( 2018 ) . MicroRNA profiles are associated with lymphocyte count after a major traumatic injury: a potential role for immunometabolism? . British Journal of Anaesthesia vol. 121 , ( 2 ) e23 - e24 .

John C, Watson D, Russ D, Goldmann K, Ehrenstein M, Pitzalis C, Lewis M, Barnes M ( 2018 ) . M3C: Monte Carlo reference-based consensus clustering . Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob java.io.Serializable ,

Kapil V, Rathod KS, Khambata RS, Bahra M, Velmurugan S, Purba A, Watson DS, Barnes MR et al. ( 2018 ) . Sex differences in the nitrate-nitrite-NO• pathway: Role of oral nitrate-reducing bacteria . Free Radical Biology and Medicine vol. 126 , 113 - 121 .

Lewis MJ, Barnes MR ( 2018 ) . RNA sequencing and machine learning as molecular scalpels . Nat Rev Rheumatol vol. 14 , ( 7 ) 388 - 390 .

Howard SR, Oleari R, Poliandri A, Chantzara V, Fantin A, Ruiz-Babot G, Metherell LA, Cabrera CP et al. ( 2018 ) . HS6ST1 Insufficiency Causes Self-Limited Delayed Puberty in Contrast With Other GnRH Deficiency Genes . The Journal of Clinical Endocrinology & Metabolism vol. 103 , ( 9 ) 3420 - 3429 .

Warren HR, Evangelou E, Mosen D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al. ( 2018 ) . GENETIC ANALYSIS OF OVER ONE MILLION PEOPLE IDENTIFIES 535 NOVEL LOCI ASSOCIATED WITH BLOOD PRESSURE AND RISK OF CARDIOVASCULAR DISEASE . Journal of Hypertension . vol. 36 ,

Taylor JC, Bongartz T, Massey J, Mifsud B, Spiliopoulou A, Scott IC, Wang J, Morgan M et al. ( 2018 ) . Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients . The Pharmacogenomics Journal vol. 18 , ( 4 ) 528 - 538 .

Marsh S, Caley MP, Martins V, Chen M, McGrath J, Barnes M, O'Toole EA ( 2018 ) . 812 Type VII collagen and Nesprin 2, LINCing the basement membrane to altered cell cycle and increased DNA damage . Journal of Investigative Dermatology . vol. 138 ,

Foulkes AC, Watson DS, Barnes MR ( 2018 ) . Bioinformatics for dermatology: why we should learn about code . Br J Dermatol vol. 178 , ( 4 ) 984 - 984 .

Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA et al. ( 2018 ) . Erratum: The RA-MAP Consortium: a working model for academia–industry collaboration . Nature Reviews Rheumatology vol. 14 , ( 2 ) 119 - 119 .

Mancini A, Howard SR, Cabrera CP, Barnes MR, Heger S, Guasti L, Ojeda S, Dunkel L ( 2018 ) . <i>EAP1</i> Mutations Cause an Impaired Transcriptional Activity on GnRH Promoter That Leads to Self-Limited Delayed Puberty . HORMONE RESEARCH IN PAEDIATRICS . vol. 90 , 20 - 20 .

Thorneloe RJ, Griffiths CEM, Emsley R, Ashcroft DM, Cordingley L, Barker J, Benham M, Burden D et al. ( 2017 ) . Intentional and Unintentional Medication Non-Adherence in Psoriasis: The Role of Patients’ Medication Beliefs and Habit Strength . Journal of Investigative Dermatology vol. 138 , ( 4 ) 785 - 794 .

Howard SR, Guasti L, Poliandri A, David A, Cabrera CP, Barnes MR, Wehkalampi K, O’Rahilly S et al. ( 2017 ) . Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty . The Journal of Clinical Endocrinology & Metabolism vol. 103 , ( 2 ) 649 - 659 .

Howard S, Andre V, Guasti L, Cabrera C, Barnes M, Cariboni A, Dunkel L ( 2017 ) . Patients with self-limited delayed puberty harbour mutations in multiple genes controlling GnRH neuronal development . Endocrine Abstracts

Marsh S, Caley M, Martins V, Barnes MR, Chen M, O'Toole EA ( 2017 ) . Loss of keratinocyte type VII collagen induces increased DNA damage in vitro and in vivo . JOURNAL OF INVESTIGATIVE DERMATOLOGY . Conference: ESDR 2017 vol. 137 , S225 - S225 .

Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, Manning AK, Grarup N et al. ( 2017 ) . New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals . Circulation Genomic and Precision Medicine vol. 10 , ( 5 )

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P et al. ( 2017 ) . Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk . Nat Genet vol. 49 , ( 10 ) 1558 - 1558 .

Foulkes AC, Watson DS, Griffiths CEM, Warren RB, Huber W, Barnes MR ( 2017 ) . Research Techniques Made Simple: Bioinformatics for Genome-Scale Biology . Journal of Investigative Dermatology vol. 137 , ( 9 ) e163 - e168 .

Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP et al. ( 2017 ) . Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney . Hypertension vol. 70 , ( 3 ) e4 - e19 .

MARINO S, Dibenedetto S, Niklison-Chirou M, Cabrera C, Ellis M, Robson LG, Knopp P, Barnes M et al. ( 2017 ) . Enhanced energetic state and protection from oxidative stress in human myoblasts overexpressing BMI1 . Stem Cell Reports

CABRERA CP, MANSON J, SHEPHERD JM, TORRANCE HD, WATSON D, LONGHI MP, HOTI M, PATEL MB et al. ( 2017 ) . Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma . PLoS Medicine

Sordi R, Nandra KK, Chiazza F, Johnson FL, Cabrera CP, Torrance HD, Yamada N, Patel NSA et al. ( 2017 ) . Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation . Ann Surg vol. 265 , ( 2 ) 408 - 417 .

Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al. ( 2017 ) . Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study . PLoS Med vol. 14 , ( 7 )

Bodagh N, Archbold A, Weerackody R, Barnes M, Robson J, Timmis A ( 2017 ) . 100 Powerform for real-time entry of routine cardiac outpatient data into the electronic health record: application for audit and research . Heart . vol. 103 ,

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P et al. ( 2017 ) . Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk . Nat Genet vol. 49 , ( 3 ) 403 - 415 .

Howard SR, Andre V, Guasti L, Cabrera CP, Barnes MR, Cariboni A, Dunkel L ( 2017 ) . DISCOVERY OF MUTATIONS IN MULTIPLE GENES CONTROLLING GNRH NEURONAL MIGRATION AND DEVELOPMENT IN PATIENTS WITH SELF-LIMITED DELAYED PUBERTY . HORMONE RESEARCH IN PAEDIATRICS . vol. 88 , 59 - 59 .

Gagliano SA, Pouget JG, Hardy J, Knight J, Barnes MR, Ryten M, Weale ME ( 2016 ) . Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases . Annals of Clinical and Translational Neurology vol. 3 , ( 12 ) 924 - 933 .

Mancini A, Howard SR, Ruiz-Babot G, Cabrera CP, Barnes MR, Guasti L, Dunkel L . LGR4 and EAP1 mutations are implicated in the phenotype of self-limited delayed puberty . Endocrine Abstracts .

Hosking A, Koulouroudias M, Zemrak F, Moon JC, Rossi A, Lee A, Barnes MR, Boubertakh R et al. ( 2016 ) . Evaluation of splenic switch off in a tertiary imaging centre: validation and assessment of utility . European Heart Journal Cardiovascular Imaging

Shaked A, Chang B, Barnes MR, Sayre P, Li YR, Asare S, DesMarais M, Holmes MV et al. ( 2016 ) . An ectopically expressed serum miRNA signature is prognostic, diagnostic, and biologically related to liver allograft rejection . Hepatology vol. 65 , ( 1 ) 269 - 280 .

Smit RA, Postmus I, Trompet S, Barnes MR, Warren H, Arsenault BJ, Chasman DI, Cupples LA et al. ( 2016 ) . Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment . Pharmacogenomics vol. 17 , ( 15 ) 1621 - 1628 .

MUNROE PB ( 2016 ) . The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals . Nature Genetics

Foulkes AC, Watson DS, Rattray NJ, Donaldson M, Goodacre R, Reynolds N, Griffiths CE, Warren RB et al. ( 2016 ) . 039 Systems biology approach to the analysis of pharmacogenomic data in psoriasis . Journal of Investigative Dermatology . vol. 136 ,

Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE et al. ( 2016 ) . Meta-analysis of genome-wide association studies of HDL cholesterol response to statins . Journal of Medical Genetics

Broad J, Maurel D, Kung VWS, Hicks GA, Schemann M, Barnes MR, Kenakin TP, Granier S et al. ( 2016 ) . Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design . Scientific Reports vol. 6 , ( 1 )

Jia Z, Liu Y, Guan N, Bo X, Luo Z, Barnes MR ( 2016 ) . Cogena, a novel tool for co-expressed gene-set enrichment analysis, applied to drug repositioning and drug mode of action discovery . BMC Genomics vol. 17 , ( 1 )

Narasimhan VM, Hunt KA, Mason D, Baker CL, Karczewski KJ, Barnes MR, Barnett AH, Bates C et al. ( 2016 ) . Health and population effects of rare gene knockouts in adult humans with related parents . Science vol. 352 , ( 6284 ) 474 - 477 .

HOWARD SR, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell LA, Sternberg MJE et al. ( 2016 ) . IGSF10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty . EMBO Molecular Medicine vol. 8 , ( 6 ) 626 - 42 .

Tragante V, Braenne I, Moore JH, Barnes MR, Erdmann J, Asselbergs FW ( 2016 ) . Evaluating CAD/MI loci as targets for prevention of myocardial infarction . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION vol. 46 , 20 - 21 .

Reglero N, Beal R, Cabrera C, Pickworth C, Golding M, Whiteford J, Nightingale T, Imhof B et al. ( 2016 ) . JAM‐C deficiency primes endothelial cells for a pro‐inflammatory state . The FASEB Journal . vol. 30 ,

Howard S, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell L, Sternberg M et al. ( 2016 ) . Role of IGSF10 mutations in self-limited delayed puberty . The Lancet . vol. 387 ,

Gagliano SA, Pouget JG, Hardy J, Barnes MR, Knight J, Ryten M, Weale ME ( 2016 ) . Genetic Variability in Both the Adaptive and Innate Immune Systems Contribute to Alzheimer's and Parkinson's Disease Risk . GENETIC EPIDEMIOLOGY . vol. 40 , 637 - 637 .

Griffiths CEM, Barnes MR, Burden AD, Nestle FO, Reynolds NJ, Smith CH, Warren RB, Barker JNWN et al. ( 2015 ) . Establishing an Academic–Industrial Stratified Medicine Consortium: Psoriasis Stratification to Optimize Relevant Therapy . Journal of Investigative Dermatology vol. 135 , ( 12 ) 2903 - 2907 .

Howard S, Poliandre A, Storr HL, Metherell LA, Cabrera C, Warren H, Barnes M, Wehkalampi K et al. ( 2015 ) . Mutations in HS6ST1 cause self-limited delayed puberty (DP) in addition to idiopathic hypogonadotropic hypogonadism (IHH) . Endocrine Abstracts

Howard S, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell L, Cabrera C et al. ( 2015 ) . Mutations in IGSF10 cause self-limited delayed puberty . Endocrine Abstracts

Kokkinopoulos I, Ishida H, Saba R, Ruchaya P, Cabrera C, Struebig M, Barnes M, Terry A et al. ( 2015 ) . Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo . PLOS ONE vol. 10 , ( 10 )

Howard S, Poliandri A, Storr H, Metherell L, Cabrera C, Barnes M, Warren H, Wehkalampi K et al. ( 2015 ) . Mutations in HS6ST1 are causal in self-limited delayed puberty as well as idiopathic hypogonadotropic hypogonadism . Endocrine Abstracts

Howard S, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell L, Sternberg M et al. ( 2015 ) . Mutations in IGSF10 cause self-limited delayed puberty, via disturbance of GnRH neuronal migration . Endocrine Abstracts

Owen H, Torrance H, Barnes M, Brohi K, Knight J, Hinds C, O'Dwyer M ( 2015 ) . The Role of Micrornas in The Development of Hospital Acquired Infection in Polytrauma Patients . Intensive Care Medicine Experimental vol. 3 , ( Suppl 1 )

Jia Z, Zhang X, Guan N, Bo X, Barnes MR, Luo Z ( 2015 ) . Gene Ranking of RNA-Seq Data via Discriminant Non-Negative Matrix Factorization . PLOS ONE vol. 10 , ( 9 )

Gagliano SA, Ravji R, Barnes MR, Weale ME, Knight J ( 2015 ) . Smoking Gun or Circumstantial Evidence? Comparison of Statistical Learning Methods using Functional Annotations for Prioritizing Risk Variants . Scientific Reports vol. 5 , ( 1 )

Lanktree MB, Elbers CC, Li Y, Zhang G, Duan Q, Karczewski KJ, Guo Y, Tragante V et al. ( 2015 ) . Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration[S] . Journal of Lipid Research vol. 56 , ( 9 ) 1781 - 1786 .

Carlotti E, Floyd J, Murray-Brown W, Barnes M, Mehr R, Bombardieri M, Pitzalis C ( 2015 ) . FRI0008 Longitudinal Analysis of the IGH-VH Gene by High-Throughput Sequencing in Early Rheumatoid Arthritis Paired Biopsies and its Association with Response to Dmards . Annals of the Rheumatic Diseases . vol. 74 ,

Taylor PN, Porcu E, Chew S, Campbell PJ, Traglia M, Brown SJ, Mullin BH, Shihab HA et al. ( 2015 ) . Erratum: Whole-genome sequence-based analysis of thyroid function . Nature Communications vol. 6 , ( 1 )

Rodriguez S, Gaunt TR, Guo Y, Zheng J, Barnes MR, Tang W, Danish F, Johnson A et al. ( 2015 ) . Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array . European Journal of Human Genetics vol. 24 , ( 1 ) 106 - 112 .

Peyrot WJ, Lee SH, Milaneschi Y, Abdellaoui A, Byrne EM, Esko T, de Geus EJC, Hemani G et al. ( 2015 ) . The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects . Molecular Psychiatry vol. 20 , ( 6 ) 735 - 743 .

Taylor PN, Porcu E, Chew S, Campbell PJ, Traglia M, Brown SJ, Mullin BH, Shihab HA et al. ( 2015 ) . Whole-genome sequence-based analysis of thyroid function . Nature Communications vol. 6 , ( 1 )

Rucker JJH, Tansey KE, Rivera M, Pinto D, Cohen-Woods S, Uher R, Aitchison KJ, Craddock N et al. ( 2015 ) . Phenotypic Association Analyses With Copy Number Variation in Recurrent Depressive Disorder . Biological Psychiatry vol. 79 , ( 4 ) 329 - 336 .

Cabrera CP, Ng FL, Warren HR, Barnes MR, Munroe PB, Caulfield MJ ( 2015 ) . Exploring hypertension genome‐wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics . WIREs Mechanisms of Disease vol. 7 , ( 2 ) 73 - 90 .

O'Dushlaine C, Rossin L, Lee PH, Duncan L, Parikshak NN, Newhouse S, Ripke S, Neale BM et al. ( 2015 ) . Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways . NATURE NEUROSCIENCE vol. 18 , ( 2 ) 199 - 209 .

Maier R, Moser G, Chen G-B, Ripke S, Consortium C-DWGOTPG, Absher D, Agartz I, Akil H et al. ( 2015 ) . Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder . American Journal of Human Genetics vol. 96 , ( 2 ) 283 - 294 .

Gagliano SA, Ravji R, Barnes MR, Weale ME, Knight J ( 2015 ) . A Methods Comparison: In silico prioritization of genetic risk variants using functional genomic information . GENETIC EPIDEMIOLOGY . vol. 39 , 549 - 550 .

Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K et al. ( 2014 ) . Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins . Nat Commun vol. 5 ,

Marino S, Ceric D, Ricci B, Barnes M ( 2014 ) . O4.07A NOVEL POLYCOMB FEED FORWARD LOOP IN GLIOBLASTOMA MULTIFORME . Neuro-Oncology vol. 16 , ( suppl_2 ) ii8 - ii8 .

Voros S, Maurovich-Horvat P, Marvasty IB, Bansal AT, Barnes MR, Vazquez G, Murray SS, Voros V et al. ( 2014 ) . Precision phenotyping, panomics, and system-level bioinformatics to delineate complex biologies of atherosclerosis: Rationale and design of the “Genetic Loci and the Burden of Atherosclerotic Lesions” study . Journal of Cardiovascular Computed Tomography vol. 8 , ( 6 ) 442 - 451 .

Marino S, Ricci B, Greco A, Acquati S ( 2014 ) . A NOVEL POLYCOMB FEED FORWARD LOOP IN GLIOBLASTOMA MULTIFORME . Neuro-Oncology vol. 16 , ( suppl_3 ) iii17 - iii17 .

Gagliano SA, Barnes MR, Weale ME, Knight J ( 2014 ) . A Bayesian method to incorporate hundreds of functional characteristics with association evidence to improve variant prioritization . PLoS ONE vol. 9 , ( 5 )

Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T et al. ( 2014 ) . Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci . Am J Hum Genet vol. 94 , ( 3 ) 349 - 360 .

Howard S, Guasti L, Storr H, Metherell L, Cariboni A, Barnes M, Cabrera C, Wehkalampi K et al. ( 2014 ) . A novel gene affecting the timing of puberty . Endocrine Abstracts

Ricci B, Ceric D, Barnes M, Marino S ( 2014 ) . A NOVEL POLYCOMB FEED FORWARD LOOP IN GLIOBLASTOMA MULTIFORME . NEURO-ONCOLOGY . vol. 16 ,

Yoneyama S, Guo Y, Lanktree MB, Barnes MR, Elbers CC, Karczewski KJ, Padmanabhan S, Bauer F et al. ( 2014 ) . Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations . HUMAN MOLECULAR GENETICS vol. 23 , ( 9 ) 2498 - 2510 .

Marsh S, Martins V, Caley M, Barnes M, Donaldson M, O'Toole E ( 2014 ) . Global transcriptomic changes in primary keratinocytes with loss of basement membrane genes . BRITISH JOURNAL OF DERMATOLOGY . vol. 170 , E37 - E38 .

Foulkes AC, Rattray NJW, Correa E, Trivedi DK, Al-Sharqi A, Parslew R, Barnes M, Goodacre R et al. ( 2014 ) . Modulation of metabolomic signature on biological treatment with etanercept in psoriasis . BRITISH JOURNAL OF DERMATOLOGY . vol. 171 , E169 - E169 .

Trompet S, Postmus I, Deshmukh HA, Barnes MR, Psaty BM, Tardif JC, Hitman G, Krauss RM et al. ( 2014 ) . Pharmacogenetic GWAS meta-analysis of LDL cholesterol response to statins . EUROPEAN HEART JOURNAL . vol. 35 , 370 - 370 .

Foulkes AC, Carr DF, Al-Sharqi A, Parslew R, Pirmohamed M, Reynolds NJ, Donaldson M, Barnes M et al. ( 2014 ) . Pharmacogenomic signatures of response to etanercept therapy for psoriasis . BRITISH JOURNAL OF DERMATOLOGY . vol. 171 , E114 - E115 .

Marsh S, Martins V, Caley M, Barnes M, Donaldson M, O'toole E ( 2014 ) . RNA-Seqing the skin basement membrane . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S25 - S25 .

Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ et al. ( 2013 ) . Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs . Nat Genet vol. 45 , ( 9 ) 984 - 994 .

Munroe PB, Barnes MR, Caulfield MJ ( 2013 ) . Advances in blood pressure genomics . Circ Res vol. 112 , ( 10 ) 1365 - 1379 .

Howard S, Barnes M, Storr H, Wehkalampi K, Metherell L, Dunkel L ( 2013 ) . Familial constitutional delay in growth and puberty is a condition with significant genetic heterogeneity and limited overlap with the timing of puberty in the general population . Endocrine Abstracts1 - 1 .

Sullivan PF, Daly MJ, Ripke S, Lewis CM, Lin D-Y, Wray NR, Neale B, Levinson DF et al. ( 2013 ) . A mega-analysis of genome-wide association studies for major depressive disorder . MOLECULAR PSYCHIATRY vol. 18 , ( 4 ) 497 - 511 .

Rucker JJH, Breen G, Pinto D, Pedroso I, Lewis CM, Cohen-Woods S, Uher R, Schosser A et al. ( 2013 ) . Genome-wide association analysis of copy number variation in recurrent depressive disorder . MOLECULAR PSYCHIATRY vol. 18 , ( 2 ) 183 - 189 .

Sanseau P, Agarwal P, Barnes MR, Pastinen T, Richards JB, Cardon LR, Mooser V ( 2013 ) . Rational drug repositioning by medical genetics Reply . NATURE BIOTECHNOLOGY vol. 31 , ( 12 ) 1082 - 1082 .

Best LG, Saxena R, Anderson CM, Barnes MR, Hakonarson H, Falcon G, Martin C, Castillo BA et al. ( 2013 ) . Two Variants of the C-Reactive Protein Gene Are Associated with Risk of Pre-Eclampsia in an American Indian Population . PLOS ONE vol. 8 , ( 8 ) Article ARTN e71231 ,

( 2012 ) . A COMT gene haplotype associated with methamphetamine abuse . Pharmacogenetics and Genomics vol. 22 , ( 7 )

Barnes MR ( 2012 ) . An Open Innovation Ecosystem for Drug Discovery . MEDCHEMCOMM vol. 3 , ( 1 ) MCW92 - MCW97 .

Pedroso I, Lourdusamy A, Rietschel M, Noethen MM, Cichon S, McGuffin P, Al-Chalabi A, Barnes MR et al. ( 2012 ) . Common Genetic Variants and Gene-Expression Changes Associated with Bipolar Disorder Are Over-Represented in Brain Signaling Pathway Genes . BIOLOGICAL PSYCHIATRY vol. 72 , ( 4 ) 311 - 317 .

Sanseau P, Agarwal P, Barnes MR, Pastinen T, Richards JB, Cardon LR, Mooser V ( 2012 ) . Use of genome-wide association studies for drug repositioning . NATURE BIOTECHNOLOGY vol. 30 , ( 4 ) 317 - 320 .

Knight J, Barnes MR, Breen G, Weale ME ( 2011 ) . Using functional annotation for the Empirical determination of Bayes factors for genome-wide association study analysis . PLoS ONE vol. 6 , ( 4 )

Dow DJ, Huxley-Jones J, Hall JM, Francks C, Maycox PR, Kew JNC, Gloger IS, Mehta NAL et al. ( 2011 ) . <i>ADAMTSL3</i> as a candidate gene for schizophrenia: Gene sequencing and ultra-high density association analysis by imputation . SCHIZOPHRENIA RESEARCH vol. 127 , ( 1-3 ) 28 - 34 .

Jugurnauth SK, Chen CK, Barnes MR, Li T, Lin SK, Liu HC, Collier DA, Breen G ( 2011 ) . A COMT gene haplotype associated with methamphetamine abuse . Pharmacogenetics and Genomics vol. 21 , ( 11 ) 731 - 740 .

Xu C-F, Reck BH, Goodman VL, Xue Z, Huang L, Barnes MR, Koshy B, Spraggs CF et al. ( 2011 ) . Association of the <i>hemochromatosis</i> gene with pazopanib-induced transaminase elevation in renal cell carcinoma . JOURNAL OF HEPATOLOGY vol. 54 , ( 6 ) 1237 - 1243 .

Barnes MR, Huxley-Jones J, Maycox PR, Lennon M, Thornber A, Kelly F, Bates S, Taylor A et al. ( 2011 ) . Transcription and Pathway Analysis of the Superior Temporal Cortex and Anterior Prefrontal Cortex in Schizophrenia . JOURNAL OF NEUROSCIENCE RESEARCH vol. 89 , ( 8 ) 1218 - 1227 .

Barnes M, Rompe JD, Furia J, Maffulli N ( 2010 ) . Letter to the Editor . The American Journal of Sports Medicine vol. 38 , ( 11 ) np1 - np2 .

Lewis CM, Ng MY, Butler AW, Cohen-Woods S, Uher R, Pirlo K, Weale ME, Schosser A et al. ( 2010 ) . Genome-Wide Association Study of Major Recurrent Depression in the UK Population . AM J PSYCHIAT vol. 167 , ( 8 ) 949 - 957 .

Maycox PR, Kelly F, Taylor A, Bates S, Reid J, Logendra R, Barnes MR, Larminie C et al. ( 2010 ) . Erratum: Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function . Molecular Psychiatry vol. 15 , ( 4 ) 442 - 443 .

Barnes MR, Breen G ( 2010 ) . A short primer on the functional analysis of copy number variation for biomedical scientists . Methods Mol Biol vol. 628 , 119 - 135 .

Barnes MR ( 2010 ) . Exploring the landscape of the genome . Methods Mol Biol vol. 628 , 21 - 38 .

Barnes MR ( 2010 ) . Genetic variation analysis for biomedical researchers: a primer . Methods Mol Biol vol. 628 , 1 - 20 .

Uher R, Perroud N, Ng MYM, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A et al. ( 2010 ) . Genome-Wide Pharmacogenetics of Antidepressant Response in the GENDEP Project . AMERICAN JOURNAL OF PSYCHIATRY vol. 167 , ( 5 ) 555 - 564 .

Barnes MR, Breen G ( 2010 ) . Preface: "Your genome is an email attachment" .

Maycox PR, Kelly F, Taylor A, Bates S, Reid J, Logendra R, Barnes MR, Larminie C et al. ( 2009 ) . Erratum: Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function . Molecular Psychiatry vol. 14 , ( 12 ) 1146 - 1146 .

Barnes MR, Harland L, Foord SM, Hall MD, Dix I, Thomas S, Williams-Jones BI, Brouwer CR ( 2009 ) . Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery . Nat Rev Drug Discov vol. 8 , ( 9 ) 701 - 708 .

Maycox PR, Kelly F, Taylor A, Bates S, Reid J, Logendra R, Barnes MR, Larminie C et al. ( 2009 ) . Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function . MOLECULAR PSYCHIATRY vol. 14 , ( 12 ) 1083 - 1094 .

Rujescu D, Ingason A, Cichon S, Pietilainen OPH, Barnes MR, Toulopoulou T, Picchioni M, Vassos E et al. ( 2009 ) . Disruption of the neurexin 1 gene is associated with schizophrenia . HUMAN MOLECULAR GENETICS vol. 18 , ( 5 ) 988 - 996 .

Huxley-Jones J, Foord SM, Barnes MR ( 2009 ) . Drug discovery in the extracellular matrix . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY vol. 90 , ( 1 ) A80 - A81 .

Knight J, Barnes MR, Breen G, Weale ME ( 2009 ) . Functional annotation of GWAS hits . GENETIC EPIDEMIOLOGY . vol. 33 , 787 - 788 .

Baranzini SE, Galwey NW, Wang J, Khankhanian P, Lindberg R, Pelletier D, Wu W, Uitdehaag BMJ et al. ( 2009 ) . Pathway and network-based analysis of genome-wide association studies in multiple sclerosis . HUMAN MOLECULAR GENETICS vol. 18 , ( 11 ) 2078 - 2090 .

Huxley-Jones J, Foord SM, Barnes MR ( 2008 ) . Drug discovery in the extracellular matrix . Drug Discov Today vol. 13 , ( 15-16 ) 685 - 694 .

Li H, Wetten S, Li L, St Jean PL, Upmanyu R, Surh L, Hosford D, Barnes MR et al. ( 2008 ) . Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease . Arch Neurol vol. 65 , ( 1 ) 45 - 53 .

Bansal AT, Barnes MR ( 2008 ) . Genomics in drug discovery: The best things come to those who wait . CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT vol. 11 , ( 3 ) 303 - 310 .

Pettersson F, Morris AP, Barnes MR, Cardon LR ( 2008 ) . Goldsurfer2 (Gs2): A comprehensive tool for the analysis and visualization of genome wide association studies . BMC BIOINFORMATICS vol. 9 , Article ARTN 138 ,

Zhu G, Carlsen K, Carlsen K-H, Lenney W, Silverman M, Whyte MK, Hosking L, Helms P et al. ( 2008 ) . Polymorphisms in the endothelin-1 (EDN1) are associated with asthma in two populations . GENES AND IMMUNITY vol. 9 , ( 1 ) 23 - 29 .

Chondrogiannis S, Barnes M, Osborne M, Yao L ( 2007 ) . Point of Connection Voltage Regulation Strategies for AC Connected Large Offshore Wind Farms . Wind Engineering vol. 31 , ( 6 ) 453 - 473 .

Southan C, Ulvsbäck M, Barnes MR ( 2007 ) . A Bioinformatics Perspective on Genetics in Drug Discovery and Development . 495 - 528 .

Barnes MR ( 2007 ) . Bioinformatics Challenges for the Geneticist . 1 - 16 .

Barnes MR ( 2007 ) . Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data: Second Edition . Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data: Second Edition1 - 554 .

Southan C, Barnes MR ( 2007 ) . Finding, Delineating and Analysing Genes . 85 - 104 .

Barnes MR ( 2007 ) . Integrating Genetics, Genomics and Epigenomics to Identify Disease Genes . 185 - 215 .

Barnes MR, Derwent PS ( 2007 ) . Needle in a Haystack? Dealing with 500 000 SNP Genome Scans . 447 - 493 .

Brown JR, Deharo S, Dancis B, Barnes MR, Sanseau P ( 2007 ) . Non-Coding RNA Bioinformatics . 343 - 368 .

Plumpton M, Barnes MR ( 2007 ) . Predictive Functional Analysis of Polymorphisms: An Overview . 247 - 280 .

Barnes MR ( 2007 ) . Preface . Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data: Second Edition

Barnes MR ( 2007 ) . Bioinformatics for Geneticists . John Wiley & Sons

Teh MT, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM et al. ( 2007 ) . Erratum: Role for WNT16B in human epidermal keratinocyte proliferation and differentiation (Journal of Cell Science vol. 120 (330-339)) . Journal of Cell Science vol. 120 , ( 5 )

Teh MT, Blaydon D, Ghali LR, Edmunds S, Pantazi E, Barnes MR, Leigh IM, Kelsell DP et al. ( 2007 ) . Role for WNT16B in human epidermal keratinocyte proliferation and differentiation . J CELL SCI vol. 120 , ( 2 ) 330 - 339 .

Pettersson F, Morris AP, Derwent PS, Barnes MR, Cardon LR ( 2007 ) . GOLDsurfer2: A comprehensive tool for the analysis and visualization of whole genome association studies . GENETIC EPIDEMIOLOGY . vol. 31 , 494 - 494 .

Barnes MR ( 2007 ) . Gaining insight into human population- specific selection pressure . Comparative Genomics: Basic and Applied Research ,

Philpott MP, Kelsell DP, Leigh IM, TEH M, Briggs V, Pantazi E, Edmunds S, Blaydon D et al. ( 2007 ) . Role for WNT16B in Human Epidermal Keratinocyte Proliferation and Differentiation . Journal Cell Science vol. 120 , ( 2 ) 330 - 339 .

Barnes MR, Deharo S, Grocock RJ, Brown JR, Sanseau P ( 2007 ) . The micro RNA target paradigm: a fundamental and polymorphic control layer of cellular expression . EXPERT OPINION ON BIOLOGICAL THERAPY vol. 7 , ( 9 ) 1387 - 1399 .

Barnes MR ( 2006 ) . Navigating the HapMap . Brief Bioinform vol. 7 , ( 3 ) 211 - 224 .

Barnes MR, Holbrook J, Feild JA, Searls DB, Sanseau P ( 2006 ) . Risk in drug trials . LANCET vol. 368 , ( 9554 ) 2205 - 2205 .

Common JEA, Bitner-Glindzicz M, O'Toole EA, Barnes MR, Jenkins L, Forge A, Kelsell DP ( 2005 ) . Specific loss of connexin 26 expression in ductal sweat gland epithelium associated with the deletion mutation del(GJB6-D13S1830) . CLIN EXP DERMATOL vol. 30 , ( 6 ) 688 - 693 .

Prabhakar U, Conway TM, Murdock P, Mooney JL, Clark S, Hedge P, Bond BC, Jazwinska EC et al. ( 2005 ) . Correlation of protein and gene expression profiles of inflammatory proteins after endotoxin challenge in human subjects . DNA AND CELL BIOLOGY vol. 24 , ( 7 ) 410 - 431 .

Scott BB, Zaratin PF, Clarke GD, Barnes MR, Murdock PR, Lynch FJ, Duckworth M ( 2004 ) . C20orf9-003 (ACI-1), a gene localized on chromosome 20q13.12 encoding for a 49 kD cytoplasmic protein with a putative nucleotide binding site . DNA SEQUENCE vol. 15 , ( 1 ) 1 - 8 .

Barnes MR, Gray IC ( 2003 ) . Concluding Remarks: Final Thoughts and Future Trends . Bioinformatics for Geneticists , Wiley

Barnes MR ( 2003 ) . Genetic Studies from Genomic Sequence . Bioinformatics for Geneticists , Wiley

Barnes MR ( 2003 ) . Genetic and Physical Map Resources – An Integrated View . Bioinformatics for Geneticists , Wiley

Barnes MR ( 2003 ) . Human Genetic Variation: Databases and Concepts . Bioinformatics for Geneticists , Wiley

Barnes MR, Southan C ( 2003 ) . Internet Resources for the Geneticist . Bioinformatics for Geneticists , Wiley

Barnes MR, Gray IC ( 2003 ) . Introduction: The Role of Genetic Bioinformatics . Bioinformatics for Geneticists , Wiley

Barnes MR ( 2003 ) . Predictive Functional Analysis of Polymorphisms: An Overview . Bioinformatics for Geneticists , Wiley

Hosking LK, Boyd PR, Xu CF, Nissum M, Cantone K, Purvis IJ, Khakhar R, Barnes MR et al. ( 2002 ) . Linkage disequilibrium mapping identifies a 390 kb region associated with CYP2D6 poor drug metabolising activity . Pharmacogenomics J vol. 2 , ( 3 ) 165 - 175 .

Barnes MR ( 2002 ) . Psychiatric genetics <i>in silico</i>:: databases and tools for psychiatric geneticists . PSYCHIATRIC GENETICS vol. 12 , ( 2 ) 67 - 73 .

Dow D, Devitt PJ, Candlin A, Gray IC, Barnes MR ( 2002 ) . SNP Locator - A bioinformatics tool for determining the distance between SNPs as an aid to linkage disequilibrium mapping . JOURNAL OF MEDICAL GENETICS . vol. 39 , S73 - S73 .

Barnes MR ( 2002 ) . SNP and mutation data on the Web - hidden treasures for uncovering . COMPARATIVE AND FUNCTIONAL GENOMICS vol. 3 , ( 1 ) 67 - 74 .

McGinnis RE, Fox H, Yates P, Cameron LA, Barnes MR, Gray IC, Spurr NK, Hurko O et al. ( 2001 ) . Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland . NATURE GENETICS vol. 28 , ( 2 ) 128 - 129 .

Sims MA, Field SD, Barnes MR, Shaikh N, Ellington K, Murphy KE, Spurr N, Campbell DA ( 2000 ) . Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51 . CYTOGENETICS AND CELL GENETICS vol. 89 , ( 3-4 ) 268 - 271 .

James IE, Kumar S, Barnes MR, Gress CJ, Hand AT, Dodds RA, Connor JR, Bradley BR et al. ( 2000 ) . FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis . OSTEOARTHRITIS AND CARTILAGE vol. 8 , ( 6 ) 452 - 463 .

Fear MW, Kelsell DP, Spurr NK, Barnes MR ( 2000 ) . Wnt-16a, a novel Wnt-16 isoform, which shows differential expression in adult human tissues . BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS vol. 278 , ( 3 ) 814 - 820 .

Wilgoss A, Leigh IM, Barnes MR, Dopping-Hepenstal P, Eady RA, Walter JM, Kennedy CT, Kelsell DP ( 1999 ) . Identification of a novel mutation R42P in the gap junction protein beta-3 associated with autosomal dominant erythrokeratoderma variabilis . J Invest Dermatol vol. 113 , ( 6 ) 1119 - 1122 .

Barnes MR, Li Z ( 1999 ) . Get practical! Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins edited by Andreas D. Baxevanis and B. F. Francis Ouellette . Trends in Biotechnology vol. 17 , ( 10 )

Barnes MR, Russell RB ( 1999 ) . A lipid-binding domain in Wnt: a case of mistaken identity? . CURRENT BIOLOGY vol. 9 , ( 19 ) R717 - R718 .

Valdes AM, Chamberlain JC, Bouzyk M, Panchal S, Gale D, Barnes M, Ralston SH, Reid DM et al. ( 1999 ) . Genetics of osteoporosis: Association between ESR (11q12) and ERR1 (6q25) and bone mineral density and rate of change . JOURNAL OF BONE AND MINERAL RESEARCH vol. 14 , S333 - S333 .

Valdes AM, Bouzyk M, O'Brien E, Gale D, Panchal S, Barnes M, Ralston S, Reid D et al. ( 1999 ) . Role of polymorphisms in parathyroid hormone receptor 1, transforming growth factor beta 1 and estrogen receptor in the genetics of osteoporosis . AMERICAN JOURNAL OF HUMAN GENETICS vol. 65 , ( 4 ) A470 - A470 .

Hu E, Zhu Y, Fredrickson T, Barnes M, Kelsell D, Beeley L, Brooks D ( 1998 ) . Tissue Restricted Expression of Two Human Frzbs in Preadipocytes and Pancreas Volume 247, Number 2 (1998), pages 287–293 . Biochemical and Biophysical Research Communications vol. 248 , ( 3 ) 940 - 943 .

Barnes MR, Duckworth DM, Beeley LJ ( 1998 ) . <i>Frizzled</i> proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family . TRENDS IN PHARMACOLOGICAL SCIENCES vol. 19 , ( 10 ) 399 - 400 .

Duetz WA, Wind B, van Andel JG, Barnes MR, Williams PA, Rutgers M ( 1998 ) . Biodegradation kinetics of toluene, <i>m</i>-xylene, <i>p</i>-xylene and their intermediates through the upper TOL pathway in <i>Pseudomonas putida</i> (pWW0) . MICROBIOLOGY-SGM vol. 144 , 1669 - 1675 .

Hu ED, Zhu Y, Fredrickson T, Barnes M, Kelsell D, Beeley L, Brooks D ( 1998 ) . Tissue restricted expression of two human Frzbs in preadipocytes and pancreas . BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS vol. 247 , ( 2 ) 287 - 293 .

Barnes MR, Duetz WA, Williams PA ( 1997 ) . A 3-(3-hydroxyphenyl)propionic acid catabolic pathway in Rhodococcus globerulus PWD1: Cloning and characterization of the hpp operon . JOURNAL OF BACTERIOLOGY vol. 179 , ( 19 ) 6145 - 6153 .