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Research

Publications: Dr Angus Cameron

Hetmanski JHR, de Belly H, Busnelli I, Waring T, Nair RV, Sokleva V, Dobre O, Cameron A et al. ( 2019 ) . Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration . Developmental Cell vol. 51 , ( 4 ) 460 - 475.e10 .
Hetmanski JHR, de Belly H, Nair RV, Sokleva V, Dobre O, Cameron A, Gauthier N, Lamaze C et al. ( 2019 ) . Membrane tension orchestrates rear retraction in matrix directed cell migration . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 100 , A44 - A45 .
Zur Nedden S, Orset C, Haellewyn B, Freret T, Fresser F, Eith R, Cameron AJM, Parker PJ et al. ( 2018 ) . ADORA2A-mediated protection of ischemia-reperfusion injury. Role of protein kinase N1: A new player in the pathophysiology of experimental stroke . PURINERGIC SIGNALLING . Conference: PURINERGIC SIGNALLING vol. 14 , S50 - S50 .
Tsui C, Martinez-Martin N, Gaya M, Maldonado P, Llorian M, Legrave NM, Rossi M, MacRae JI et al. ( 2018 ) . Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis . Immunity vol. 48 , ( 6 ) 1144 - 1159.e5 .
Claus J, Patel G, Autore F, Colomba A, Weitsman G, Soliman TN, Roberts S, Zanetti-Domingues LC et al. ( 2018 ) . Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface . eLife vol. 7 ,
Nedden SZ, Eith R, Schwarzer C, Zanetti L, Seitter H, Fresser F, Koschak A, Cameron AJM et al. ( 2018 ) . Protein kinase N1 critically regulates cerebellar development and long-term function . Journal of Clinical Investigation vol. 128 , ( 5 ) 2076 - 2088 .
Murray ER, Cameron AJM ( 2017 ) . Towards specific inhibition of mTORC2 . Aging vol. 9 , ( 12 ) 2461 - 2462 .
Hurst CD, Alder O, Platt FM, Droop A, Stead LF, Burns JE, Burghel GJ, Jain S et al. ( 2017 ) . Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency . Cancer Cell vol. 32 , ( 5 ) 701 - 715.e7 .
Cameron AJM, Veeriah S, Marshall JJT, Murray ER, Larijani B, Parker PJ ( 2017 ) . Uncoupling TORC2 from AGC kinases inhibits tumour growth . Oncotarget vol. 8 , ( 49 ) 84685 - 84696 .
Cenciarelli C, Marei HE, Felsani A, Casalbore P, Sica G, Puglisi MA, Cameron AJM, Olivi A et al. ( 2016 ) . PDGFRα depletion attenuates glioblastoma stem cells features by modulation of STAT3, RB1 and multiple oncogenic signals . Oncotarget
Quétier I, Marshall JJT, Spencer-Dene B, Lachmann S, Casamassima A, Franco C, Escuin S, Worrall JT et al. ( 2016 ) . Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion . Cell Reports vol. 14 , ( 3 ) 440 - 448 .
Martin-Liberal J, Cameron AJ, Claus J, Judson IR, Parker PJ, Linch M ( 2014 ) . Targeting protein kinase C in sarcoma . Biochimica et Biophysica Acta - Reviews on Cancer vol. 1846 , ( 2 ) 547 - 559 .
Linch M, Riou P, Claus J, Cameron AJ, de Naurois J, Larijani B, Ng T, McDonald NQ et al. ( 2014 ) . Functional implications of assigned, assumed and assembled PKC structures . Biochem Soc Trans vol. 42 , ( 1 ) 35 - 41 .
Linch M, Sanz-Garcia M, Rosse C, Riou P, Peel N, Madsen CD, Sahai E, Downward J et al. ( 2013 ) . Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids . Carcinogenesis vol. 35 , ( 2 ) 396 - 406 .
Linch M, Sanz-Garcia M, Soriano E, Zhang Y, Riou P, Rosse C, Cameron A, Knowles P et al. ( 2013 ) . A cancer-associated mutation in atypical protein kinase Cι occurs in a substrate-specific recruitment motif . Science Signaling vol. 6 , ( 293 )
Claus J, Cameron AJM, Parker PJ ( 2013 ) . Pseudokinase drug intervention: a potentially poisoned chalice . Biochem Soc Trans vol. 41 , ( 4 ) 1083 - 1088 .
Cameron AJM, Linch MD, Saurin AT, Escribano C, Parker PJ ( 2011 ) . mTORC2 targets AGC kinases through Sin1-dependent recruitment . Biochem J vol. 439 , ( 2 ) 287 - 297 .
Cameron AJM ( 2011 ) . Occupational hazards: allosteric regulation of protein kinases through the nucleotide-binding pocket . Biochem Soc Trans vol. 39 , ( 2 ) 472 - 476 .
Rosse C, Linch M, Kermorgant S, Cameron AJM, Boeckeler K, Parker PJ ( 2010 ) . PKC and the control of localized signal dynamics . Nat Rev Mol Cell Biol vol. 11 , ( 2 ) 103 - 112 .
Cameron AJM, Parker PJ ( 2010 ) . Protein kinase C - a family of protein kinases, allosteric effectors or both? . Adv Enzyme Regul vol. 50 , ( 1 ) 169 - 177 .
Cameron AJM, Escribano C, Saurin AT, Kostelecky B, Parker PJ ( 2009 ) . PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity . Nat Struct Mol Biol vol. 16 , ( 6 ) 624 - 630 .
Cameron AJ, Procyk KJ, Leitges M, Parker PJ ( 2008 ) . PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival . Int J Cancer vol. 123 , ( 4 ) 769 - 779 .
Saurin AT, Durgan J, Cameron AJ, Faisal A, Marber MS, Parker PJ ( 2008 ) . The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis . Nat Cell Biol vol. 10 , ( 8 ) 891 - 901 .
Durgan J, Cameron AJ, Saurin AT, Hanrahan S, Totty N, Messing RO, Parker PJ ( 2008 ) . The identification and characterization of novel PKCepsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily . Biochem J vol. 411 , ( 2 ) 319 - 331 .
Cameron AJ, De Rycker M, Calleja V, Alcor D, Kjaer S, Kostelecky B, Saurin A, Faisal A et al. ( 2007 ) . Protein kinases, from B to C . Biochem Soc Trans vol. 35 , ( Pt 5 ) 1013 - 1017 .
Hillyard DZ, Nutt CD, Thomson J, McDonald KJ, Wan RK, Cameron AJM, Mark PB, Jardine AG ( 2007 ) . Statins inhibit NK cell cytotoxicity by membrane raft depletion rather than inhibition of isoprenylation . Atherosclerosis vol. 191 , ( 2 ) 319 - 325 .
Cameron AJ, De Rycker M, Calleja V, Alcor D, Kjaer S, Kostelecky B, Saurin A, Faisal A et al. ( 2007 ) . Protein kinases, from B to C . Biochemical Society Transactions vol. 35 , ( 5 ) 1013 - 1017 .
Hillyard DZ, Cameron AJM, McDonald KJ, Thomson J, MacIntyre A, Shiels PG, Panarelli M, Jardine AG ( 2004 ) . Simvastatin inhibits lymphocyte function in normal subjects and patients with cardiovascular disease . Atherosclerosis vol. 175 , ( 2 ) 305 - 313 .
Hillyard DZ, Jardine AG, McDonald KJ, Cameron AJM ( 2004 ) . Fluvastatin inhibits raft dependent Fcgamma receptor signalling in human monocytes . Atherosclerosis vol. 172 , ( 2 ) 219 - 228 .
Cameron AJM, McDonald KJ, Harnett MM, Allen JM ( 2002 ) . Differentiation of the human monocyte cell line, U937, with dibutyryl cyclicAMP induces the expression of the inhibitory Fc receptor, FcgammaRIIb . Immunol Lett vol. 83 , ( 3 ) 171 - 179 .
McDonald KJ, Cameron AJM, Allen JM, McLay JS, Jardine AG ( 2002 ) . A pathophysiological role for tubular Fc receptors in glomerulonephritis? . JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY vol. 13 , 175A - 175A .
Hillyard DZ, Cameron AJM, McIntyre AH, Hadden MH, Marshall HE, Johnston N, Jardine AG ( 2002 ) . Inhibition of proliferation and signalling mechanisms in human lymphocytes by fluvastatin . Clin Exp Pharmacol Physiol vol. 29 , ( 8 ) 673 - 678 .
McDonald KJ, Cameron AJM, Allen JM, Jardine AG ( 2002 ) . Expression of Fc alpha/mu receptor by human mesangial cells: a candidate receptor for immune complex deposition in IgA nephropathy . Biochem Biophys Res Commun vol. 290 , ( 1 ) 438 - 442 .
Cameron AJ, Harnett MM, Allen JM ( 2001 ) . Differential recruitment of accessory molecules by FcgammaRI during monocyte differentiation . Eur J Immunol vol. 31 , ( 9 ) 2718 - 2725 .
Cameron AJ, Allen JM ( 1999 ) . The human high-affinity immunoglobulin G receptor activates SH2-containing inositol phosphatase (SHIP) . Immunology vol. 97 , ( 4 ) 641 - 647 .
Melendez A, Floto RA, Cameron AJ, Gillooly DJ, Harnett MM, Allen JM ( 1998 ) . A molecular switch changes the signalling pathway used by the Fc gamma RI antibody receptor to mobilise calcium . Curr Biol vol. 8 , ( 4 ) 210 - 221 .
Cameron AJ, Allen JM ( 1997 ) . Differential expression of the human high affinity IgG receptor Fc gamma RI and associated signalling molecules in differentiated U937 monocyte cells . Biochem Soc Trans vol. 25 , ( 3 )
Leng J, Cameron AJ, Buckel S, Kennelly PJ ( 1995 ) . Isolation and cloning of a protein-serine/threonine phosphatase from an archaeon . J Bacteriol vol. 177 , ( 22 ) 6510 - 6517 .