Skip to main content
Research

Publications: Dr Oliver Pearce

Hirani P, Gauthier V, Allen CE, Wight TN, Pearce OMT ( 2021 ) . Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of Cancer . Frontiers in Oncology vol. 11 ,
Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M et al. ( 2021 ) . A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion . iScience vol. 24 , ( 6 )
Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT et al. ( 2021 ) . Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer . iScience vol. 24 , ( 6 )
Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR, Knight MM ( 2021 ) . Mechanical stimulation modulates osteocyte regulation of cancer cell phenotype . Cancers vol. 13 , ( 12 )
Reuten R, Zendehroud S, Nicolau M, Fleischhauer L, Laitala A, Kiderlen S, Nikodemus D, Wullkopf L et al. ( 2021 ) . Basement membrane stiffness determines metastases formation . Nature Materials vol. 20 , ( 6 ) 892 - 903 .
Pearce OMT, Läubli H ( 2020 ) . A sweet approach to heat up cancer response to immunotherapy . Cancer Discovery vol. 10 , ( 12 ) 1789 - 1790 .
Zaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant-Sourdy S, Rochotte J, Brunel A, Schlaepfer D et al. ( 2020 ) . FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer . EMBO Molecular Medicine vol. 12 , ( 11 )
Wight TN, Kang I, Evanko SP, Harten IA, Chang MY, Pearce OMT, Allen CE, Frevert CW ( 2020 ) . Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation . Frontiers in Immunology vol. 11 ,
Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C et al. ( 2020 ) . Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment . Cell Reports vol. 30 , ( 2 ) 525 - 540.e7 .
Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR et al. ( 2018 ) . Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics . Journal of Proteome Research vol. 16 , ( 8 ) 3083 - 3091 .
Pearce OMT, Läubli H ( 2018 ) . Cancer Immunotherapy . Glycobiology vol. 28 , ( 9 ) 638 - 639 .
Pearce OM ( 2018 ) . Cancer glycan epitopes: biosynthesis, structure, and function . Glycobiology
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al. ( 2017 ) . Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers . Cancer Discov
Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG, Varki A ( 2017 ) . N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils . Proc Natl Acad Sci U S A vol. 114 , ( 39 ) E8155 - E8164 .
Montfort A, Pearce OMT, Maniati E, Vincent B, Bixby LM, Bo hm S, Dowe T, Wilkes EH et al. ( 2016 ) . A strong B cell response is part of the immune landscape in human high-grade serous ovarian metastases . Clinical Cancer Research
BALKWILL F, Anne Montfort, Oliver Pearce ( 2016 ) . Neoadjuvant chemotherapy modulates the immune microenvironment in metastases of tubo-ovarian high-grade serous carcinoma . Clinical Cancer Research
Pearce OMT, Läubli H ( 2015 ) . Sialic acids in cancer biology and immunity . Glycobiology vol. 26 , ( 2 ) 111 - 128 .
Gopinathan G, Milagre C, Pearce OMT, Reynolds L, Hodivala-Dilke K, Leinster A, Zhong H, Hollingsworth RE et al. ( 2015 ) . Abstract 4162: Interleukin–6 stimulates defective angiogenesis . 4162 - 4162 .
Gopinathan G, Milagre C, Pearce OMT, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE et al. ( 2015 ) . Interleukin-6 stimulates defective angiogenesis . Cancer Research vol. 75 , ( 15 ) 3098 - 3107 .
Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OMT, Kiso M, Miyagi T, Sawada M et al. ( 2015 ) . Rapid trimming of cell surface polysialic acid (PolySia) by exovesicular sialidase triggers release of preexisting surface neurotrophin . Journal of Biological Chemistry vol. 290 , ( 21 ) 13202 - 13214 .
Schwarz F, Pearce OMT, Wang X, Samraj AN, Läubli H, Garcia JO, Lin H, Fu X et al. ( 2015 ) . Siglec receptors impact mammalian lifespan by modulating oxidative stress . eLife vol. 2015 , ( 4 )
Pearce OMT, Samraj AN, Läubli H, Varki NM, Varki A ( 2015 ) . Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigens . Proceedings of the National Academy of Sciences of the United States of America vol. 112 , ( 12 )
Samraj AN, Pearce OMT, Läubli H, Crittenden AN, Bergfeld AK, Band K, Gregg CJ, Bingman AE et al. ( 2015 ) . A red meat-derived glycan promotes inflammation and cancer progression . Proceedings of the National Academy of Sciences of the United States of America vol. 112 , ( 2 ) 542 - 547 .
Pearce OMT, Läubli H, Verhagen A, Secrest P, Zhang J, Crocker PR, Varki N, Bui J et al. ( 2014 ) . Abstract 1063: Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies . 1063 - 1063 .
Läubli H, Pearce OMT, Schwarz F, Deng L, Stanczak M, Deng L, Verhagen A, Secrest P et al. ( 2014 ) . Abstract 3659: Engagement of myelomonocytic siglecs by tumor-associated ligands modulates innate immune responses to cancer . 3659 - 3659 .
Läubli H, Pearce OMT, Schwarz F, Siddiqui SS, Deng L, Stanczak MA, Deng L, Verhagen A et al. ( 2014 ) . Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer . Proceedings of the National Academy of Sciences of the United States of America vol. 111 , ( 39 ) 14211 - 14216 .
Pearce OMT, Läubli H, Verhagen A, Secrest P, Zhang J, Varki NM, Crocker PR, Bui JD et al. ( 2014 ) . Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies . Proceedings of the National Academy of Sciences of the United States of America vol. 111 , ( 16 ) 5998 - 6003 .
Pearce OMT, Läubli H, Bui J, Varki A ( 2014 ) . Hormesis in cancer immunology: Does the quantity of an immune reactant matter? . OncoImmunology vol. 3 , ( 6 )
Buchlis G, Odorizzi P, Soto PC, Pierce OMT, Hui DJ, Jordan MS, Varki A, Wherry EJ et al. ( 2013 ) . Enhanced T cell function in a mouse model of human glycosylation . Journal of Immunology vol. 191 , ( 1 ) 228 - 237 .
Bergfeld AK, Diaz SL, Lawrence R, Pearce OMT, Esko JD, Varki A ( 2012 ) . Natural occurrence of N-glycolyl-hexosamines in chondroitin/dermatan sulfates in mammalian tissues, derived from the metabolism of N-glycolylneuraminic acid . GLYCOBIOLOGY . vol. 22 , 1539 - 1539 .
Bergfeld AK, Pearce OMT, Diaz SL, Pham T, Varki A ( 2012 ) . Metabolism of vertebrate amino sugars with N-glycolyl groups: Elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid . Journal of Biological Chemistry vol. 287 , ( 34 ) 28865 - 28881 .
Bergfeld AK, Pearce OMT, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko JD, Varki A ( 2012 ) . Metabolism of vertebrate amino sugars with N-glycolyl groups: Incorporation of N-glycolylhexosamines into mammalian glycans by feeding N- glycolylgalactosamine . Journal of Biological Chemistry vol. 287 , ( 34 ) 28898 - 28916 .
Davies LRL, Pearce OMT, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Sato C et al. ( 2012 ) . Metabolism of vertebrate amino sugars with N-glycolyl groups: Resistance of α2-8-linked N-glycolylneuraminic acid to enzymatic cleavage . Journal of Biological Chemistry vol. 287 , ( 34 ) 28917 - 28931 .
Bergfeld AK, Pearce OMT, Diaz S, Pham T, Varki A ( 2012 ) . Intracellular fate of the non‐human sialic acid N‐glycolylneuraminic acid . The FASEB Journal . vol. 26 , 793.1 - 793.1 .
Pearce OMT, Varki A ( 2010 ) . Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucose . Carbohydrate Research vol. 345 , ( 9 ) 1225 - 1229 .
Pearce OMT, Fisher KD, Humphries J, Seymour LW, Smith A, Davis BG ( 2005 ) . Glycoviruses: Chemical glycosylation retargets adenoviral gene transfer . Angewandte Chemie - International Edition vol. 44 , ( 7 ) 1057 - 1061 .