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Research

Publications: Dr Sarah McClelland

Barr AR, McClelland SE ( 2022 ) . Cells on lockdown: long-term consequences of CDK4/6 inhibition . EMBO Journal
Shaikh N, McClelland SE ( 2021 ) . Diversity in chromosome numbers promotes resistance to chemotherapeutics . Developmental Cell vol. 56 , ( 17 ) 2399 - 2400 .
MacDonald C, McClelland SE ( 2021 ) . Chromosome Instability through the Ages: Parallels between Speciation and Somatic (Cancer) Evolution . Trends in Genetics vol. 37 , ( 8 ) 691 - 694 .
Mcclelland S, Tamura N, Shaikh N, Muliaditan D, Soliman T, McGuinness J, Maniati E, Moralli D et al. ( 2020 ) . Specific mechanisms of chromosomal instability indicate therapeutic sensitivities in high-grade serous ovarian carcinoma . Cancer Research
Graham TA, McClelland SE ( 2020 ) . Strands of evidence about cancer evolution . Nature vol. 583 , ( 7815 ) 207 - 209 .
Tovini L, McClelland SE ( 2020 ) . Towards restoring proper chromosome segregation and preventing ageing . EMBO Reports vol. 21 , ( 5 )
Dumont M, Gamba R, Gestraud P, Klaasen S, Worrall JT, De Vries SG, Boudreau V, Salinas-Luypaert C et al. ( 2020 ) . Human chromosome-specific aneuploidy is influenced by DNA-dependent centromeric features . EMBO Journal vol. 39 , ( 2 )
McClelland SE ( 2019 ) . Single-cell approaches to understand genome organisation throughout the cell cycle . Essays in Biochemistry vol. 63 , ( 2 ) 209 - 216 .
Johnson SC, McClelland SE ( 2019 ) . Watching cancer cells evolve through chromosomal instability . Nature vol. 570 , ( 7760 ) 166 - 167 .
Tijhuis AE, Johnson SC, McClelland SE ( 2019 ) . The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity . Molecular Cytogenetics vol. 12 , ( 1 )
Tovini L, McClelland SE ( 2019 ) . Impaired CENP-E function renders large chromosomes more vulnerable to congression failure . Biomolecules vol. 9 , ( 2 )
Currie CE, Mora-Santos M, Smith CA, McClelland SE, McAinsh AD, Millar JB ( 2018 ) . Elucidating the role of Bub1 in human checkpoint signalling . MOLECULAR BIOLOGY OF THE CELL . vol. 29 ,
Worrall JT, Tamura N, Mazzagatti A, Shaikh N, van Lingen T, Bakker B, Spierings DCJ, Vladimirou E et al. ( 2018 ) . Non-random Mis-segregation of Human Chromosomes . Cell Reports vol. 23 , ( 11 ) 3366 - 3380 .
McClelland SE ( 2017 ) . Role of chromosomal instability in cancer progression . Endocr Relat Cancer vol. 24 , ( 9 ) T23 - T31 .
Worrall JT, McClelland SE ( 2016 ) . Determining the Missegregation Rates of Individual Human Chromosomes . CYTOGENETIC AND GENOME RESEARCH . vol. 148 , 131 - 131 .
Worrall JT, McClelland SE ( 2016 ) . Determining the missegregation rates of individual human chromosomes . MOLECULAR BIOLOGY OF THE CELL . vol. 27 ,
Tamura N, Shaikh N, McGuinness JR, Bowtell D, Balkwill F, Petermann E, McClelland SE ( 2016 ) . What drives chromosomal instability in high-grade serous ovarian cancer? . MOLECULAR BIOLOGY OF THE CELL . vol. 27 ,
Burrell RA, McClelland SE, Bartek J, Swanton C ( 2014 ) . Response to Bakhoum et al . Curr Biol vol. 24 , ( 4 )
Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller MC, Shaikh N, Domingo E, Kanu N et al. ( 2013 ) . Erratum: Replication stress links structural and numerical cancer chromosomal instability (Nature (2013) 494 (492-496) DOI: 10.1038/nature11935) . Nature vol. 500 , ( 7463 )
Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller M-C, Shaikh N, Domingo E, Kanu N et al. ( 2013 ) . Replication stress links structural and numerical cancer chromosomal instability . Nature vol. 494 , ( 7438 ) 492 - 496 .
Burrell RA, McClelland SE, Endesfelder D, Rowan A, Schenk A, Sheffer M, Shaikh N, Domingo E et al. ( 2012 ) . Abstract 3105: Chromosome 18q encodes a chromosomal instability suppressor locus in colorectal cancer . 3105 - 3105 .
Birkbak NJ, Eklund AC, Li Q, McClelland SE, Endesfelder D, Tan P, Tan IB, Richardson AL et al. ( 2011 ) . Paradoxical relationship between chromosomal instability and survival outcome in cancer . Cancer Research vol. 71 , ( 10 ) 3447 - 3452 .
Jaqaman K, King EM, Amaro AC, Winter JR, Dorn JF, Elliott HL, Mchedlishvili N, McClelland SE et al. ( 2010 ) . Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases . Journal of Cell Biology vol. 188 , ( 5 ) 665 - 679 .
Burrell R, McClelland S, Juul N, Downward J, Szallasi Z, Szallasi Z, Swanton C, Swanton C ( 2009 ) . Regulators of Mitotic Transition Determine Paclitaxel Resistance In Vitro and Predict Poor Prognosis in Breast Cancer In Vivo . 2151 - 2151 .
Burrell RA, McClelland SE, Juul N, Downward J, Szallasi Z, Swanton C ( 2009 ) . Regulators of Mitotic Transition Determine Paclitaxel Resistance In Vitro and Predict Poor Prognosis in Breast Cancer In Vivo . CANCER RESEARCH . vol. 69 , 641S - 641S .
McClelland SE, McAinsh AD ( 2009 ) . Hydrodynamic analysis of human kinetochore complexes during mitosis . Methods in Molecular Biology vol. 545 , 81 - 98 .
McClelland SE, Burrell RA, Swanton C ( 2009 ) . Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy . Cell Cycle vol. 8 , ( 20 ) 3262 - 3266 .
McClelland SE, Borusu S, Amaro AC, Winter JR, Belwal M, McAinsh AD, Meraldi P ( 2007 ) . The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity . EMBO Journal vol. 26 , ( 24 ) 5033 - 5047 .
Xu C, Losytskyy MY, Kovalska VB, Kryvorotenko DV, Yarmoluk SM, McClelland S, Bianco PR ( 2007 ) . Novel, monomeric cyanine dyes as reporters for DNA helicase activity . Journal of Fluorescence vol. 17 , ( 6 ) 671 - 685 .
Porter IM, McClelland SE, Khoudoli GA, Hunter CJ, Andersen JS, McAinsh AD, Blow JJ, Swedlow JR ( 2007 ) . Bod1, a novel kinetochore protein required for chromosome biorientation . Journal of Cell Biology vol. 179 , ( 2 ) 187 - 197 .
McClelland SE, Dryden DTF, Szczelkun MD ( 2005 ) . Continuous assays for DNA translocation using fluorescent triplex dissociation: Application to type I restriction endonucleases . Journal of Molecular Biology vol. 348 , ( 4 ) 895 - 915 .