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Research

Publications: Dr Gareth Ackland

Heywood WE, Bliss E, Bahelil F, Cyrus T, Crescente M, Jones T, Iqbal S, Paredes LG et al. ( 2021 ) . Proteomic signatures for perioperative oxygen delivery in skin after major elective surgery: mechanistic sub-study of a randomised controlled trial . Br J Anaesth
Abbott TEF, Howell S, Pearse RM, Ackland GL ( 2021 ) . Mode of blood pressure monitoring and morbidity after noncardiac surgery: A prospective multicentre observational cohort study . European Journal of Anaesthesiology vol. 38 , ( 5 ) 468 - 476 .
Pearse RM, Ackland GL, Asai T, Hemmings HC ( 2021 ) . Preprints in perioperative medicine: immediacy for the greater good . British Journal of Anaesthesia vol. 126 , ( 5 ) 915 - 918 .
Schroth J, Weber V, Jones TF, Del Arroyo AG, Henson SM, Ackland GL ( 2021 ) . Preoperative lymphopaenia, mortality, and morbidity after elective surgery: systematic review and meta-analysis . British Journal of Anaesthesia
Farmer AD, Strzelczyk A, Finisguerra A, Gourine AV, Gharabaghi A, Hasan A, Burger AM, Jaramillo AM et al. ( 2021 ) . International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020) . Frontiers in Human Neuroscience vol. 14 ,
Weber V, Abbott TEF, Ackland GL ( 2021 ) . Reducing the dose of neuromuscular blocking agents with adjuncts: a systematic review and meta-analysis . British Journal of Anaesthesia vol. 126 , ( 3 ) 608 - 621 .
Shrimpton AJ, Walker SLM, Ackland GL ( 2021 ) . Erratum to ‘Angiotensin converting enzyme inhibitors and angiotensin receptor blockers’ [BJA Education 20 (2020) 362–367] (BJA Education (2020) 20(11) (362–367), (S2058534920300962), (10.1016/j.bjae.2020.07.004)) . BJA Education vol. 21 , ( 1 )
Booth LC, Yao ST, Korsak A, Farmer DGS, Hood SG, McCormick D, Boesley Q, Connelly AA et al. ( 2021 ) . Selective optogenetic stimulation of efferent fibers in the vagus nerve of a large mammal . Brain Stimulation vol. 14 , ( 1 ) 88 - 96 .
Shrimpton AJ, Walker SLM, Ackland GL ( 2020 ) . Angiotensin converting enzyme inhibitors and angiotensin receptor blockers . BJA Education vol. 20 , ( 11 ) 362 - 367 .
May SM, Abbott TEF, Del Arroyo AG, Reyes A, Martir G, Stephens RCM, Brealey D, Cuthbertson BH et al. ( 2020 ) . MicroRNA signatures of perioperative myocardial injury after elective noncardiac surgery: a prospective observational mechanistic cohort study . British Journal of Anaesthesia vol. 125 , ( 5 ) 661 - 671 .
Hadjihambi A, Karagiannis A, Theparambil SM, Ackland GL, Gourine AV ( 2020 ) . The effect of general anaesthetics on brain lactate release . European Journal of Pharmacology vol. 881 ,
May S, Abbott TEF, Gutierrez Del Arroyo A, Reyes A, Martir G, Stephens RCM, Brealey D, Cuthbertson B et al. ( 2020 ) . MicroRNA signatures of perioperative myocardial injury after elective noncardiac surgery: a prospective observational mechanistic cohort study . British Journal of Anaesthesia vol. 125 , ( 5 ) 661 - 671 .
Riedel B, Li MHG, Lee CHA, Ismail H, Cuthbertson BH, Wijeysundera DN, Ho KM, Wallace S et al. ( 2020 ) . A simplified (modified) Duke Activity Status Index (M-DASI) to characterise functional capacity: a secondary analysis of the Measurement of Exercise Tolerance before Surgery (METS) study . British Journal of Anaesthesia
Machhada A, Hosford PS, Dyson A, Ackland GL, Mastitskaya S, Gourine AV ( 2020 ) . Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure . JACC Basic to Translational Science
Wan YI, Patel A, ABBOTT TEF, Achary C, Macdonald N, Duceppe E, Sessler DI, Szczeklik W et al. ( 2020 ) . Prospective observational study of postoperative infection and outcomes after noncardiac surgery: analysis of prospective data from the VISION cohort . British Journal of Anaesthesia
Patel ABU, Stevens J, Ackland GL ( 2020 ) . Experimental medicine in anaesthesia-related research: UK and US activity . British Journal of Anaesthesia . vol. 124 ,
Walker SLM, Muthoo C, Sanchez J, Del Arroyo AG, Ackland GL ( 2020 ) . Sex influences cardiac dysfunction in early polymicrobial sepsis, independent of leucocyte-derived tumour necrosis factor-α . British Journal of Anaesthesia . vol. 124 , e204 - e205 .
Ackland GL, ABBOTT T, Jones TF, Leuwer M, Pearse R, Niebrzegowska E, Wragg A, Archbold A et al. ( 2020 ) . Early elevation in plasma high-sensitivity troponin T and morbidity after elective noncardiac surgery: prospective multicentre observational cohort study . British Journal of Anaesthesia
Duceppe E, Patel A, Chan MTV, Berwanger O, Ackland G, Kavsak PA, Rodseth R, Biccard B et al. ( 2020 ) . Preoperative n-terminal pro-b-type natriuretic peptide and cardiovascular events after noncardiac surgery: A cohort study . Annals of Internal Medicine vol. 172 , ( 2 ) 96 - 104 .
Wijeysundera D, Beattie WS, Hillis G, ABBOTT T, Shulman M, Ackland G, Mazer D, Myles P et al. ( 2019 ) . Integration of the Duke Activity Status Index into Preoperative Risk Evaluation: A Multicentre Prospective Cohort Study . British Journal of Anaesthesia
Manou-Stathopoulou V, Korbonits M, Ackland GL ( 2019 ) . Redefining the perioperative stress response: a narrative review . British Journal of Anaesthesia vol. 123 , ( 5 ) 570 - 583 .
Zarbock A, Kellum JA, Gourine AV, Ackland GL ( 2019 ) . Salvaging remote ischaemic preconditioning as a therapy for perioperative acute kidney injury . British Journal of Anaesthesia vol. 124 , ( 1 ) 8 - 12 .
May SM, Reyes A, Martir G, Reynolds J, Paredes LG, Karmali S, Stephens RCM, Brealey D et al. ( 2019 ) . Acquired loss of cardiac vagal activity is associated with myocardial injury in patients undergoing noncardiac surgery: prospective observational mechanistic cohort study . British Journal of Anaesthesia vol. 123 , ( 6 ) 758 - 767 .
del Arroyo AG, Hadjihambi A, Sanchez J, Turovsky E, Kasymov V, Cain D, Nightingale TD, Lambden S et al. ( 2019 ) . NMDA receptor modulation of glutamate release in activated neutrophils . EBioMedicine
Ackland GL, Pryor KO ( 2019 ) . Electroencephalography-guided anaesthetic administration does not impact postoperative delirium among older adults undergoing major surgery: an independent discussion of the ENGAGES trial . British Journal of Anaesthesia vol. 123 , ( 2 ) 112 - 117 .
Ackland GL, Abbott TEF, Minto G, Clark M, Owen T, Prabhu P, May SM, Reynolds JA et al. ( 2019 ) . Heart rate recovery and morbidity after noncardiac surgery: Planned secondary analysis of two prospective, multi-centre, blinded observational studies . PLoS ONE vol. 14 , ( 8 )
The Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Study Investigators ( 2019 ) . Association between complications and death within 30 days after noncardiac surgery . Canadian Medical Association Journal vol. 191 , ( 30 ) E830 - E837 .
Lau EYM, Carroll EC, Callender LA, Hood GA, Berryman V, Pattrick M, Finer S, Hitman GA et al. ( 2019 ) . Type 2 diabetes is associated with the accumulation of senescent T cells . Clinical & Experimental Immunology
Bartoszko J, Thorpe KE, Laupacis A, Wijeysundera DN, Myles PS, Shulman MA, Wallace S, Farrington C et al. ( 2019 ) . Association of preoperative anaemia with cardiopulmonary exercise capacity and postoperative outcomes in noncardiac surgery: a substudy of the Measurement of Exercise Tolerance before Surgery (METS) Study . British Journal of Anaesthesia
ABBOTT TEF, PEARSE RM, beattie S, Phull M, Beilstein C, Raj A, Grocott M, Cuthbertson B et al. ( 2019 ) . Chronotropic incompetence and myocardial injury after non-cardiac surgery: planned secondary analysis of a prospective observational international cohort study . BJA: British Journal of Anaesthesia vol. 123 , ( 1 ) 17 - 26 .
Sessler DI, Bloomstone JA, Aronson S, Berry C, Gan TJ, Kellum JA, Plumb J, Mythen MG et al. ( 2019 ) . Perioperative Quality Initiative consensus statement on intraoperative blood pressure, risk and outcomes for elective surgery . British Journal of Anaesthesia vol. 122 , ( 5 ) 563 - 574 .
Ackland GL, Brudney CS, Cecconi M, Ince C, Irwin MG, Lacey J, Pinsky MR, Grocott MP et al. ( 2019 ) . Perioperative Quality Initiative consensus statement on the physiology of arterial blood pressure control in perioperative medicine . British Journal of Anaesthesia vol. 122 , ( 5 ) 542 - 551 .
PEARSE RM, Peden C, STEPHENS T, Martin G, KAHAN B, Thomson A, Rivett K, Wells D et al. ( 2019 ) . Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery: A stepped-wedge cluster randomised trial . Lancet
Pinto BB, Filipovic M, Ackland G ( 2019 ) . Intra-operative heart rate and postoperative outcomes-rowing against the tide? . European Journal of Anaesthesiology vol. 36 , ( 2 ) 90 - 92 .
McEvoy MD, Gupta R, Koepke EJ, Feldheiser A, Michard F, Levett D, Thacker JKM, Hamilton M et al. ( 2019 ) . Perioperative Quality Initiative consensus statement on postoperative blood pressure, risk and outcomes for elective surgery . British Journal of Anaesthesia
Gourine AV, Ackland GL ( 2019 ) . Cardiac Vagus and Exercise . Physiology (Bethesda) vol. 34 , ( 1 ) 71 - 80 .
Abbott TEF, Pearse RM, Cuthbertson BH, Wijeysundera DN, Ackland GL ( 2019 ) . Cardiac vagal dysfunction and myocardial injury after non-cardiac surgery: a planned secondary analysis of the measurement of Exercise Tolerance before surgery study . British Journal of Anaesthesia
ACKLAND GL ( 2019 ) . Perioperative Quality Initiative consensus statement on preoperative blood pressure, risk and outcomes for elective surgery . British Journal of Anaesthesia
Ackland GL ( 2019 ) . What happens to the autonomic nervous system in critical illness? . Evidence-Based Practice of Critical Care ,
del Arroyo AG, Sanchez J, Patel S, Phillips S, Reyes A, Cubillos C, Fernando R, David AL et al. ( 2018 ) . Role of leucocyte caspase-1 activity in epidural-related maternal fever: a single-centre, observational, mechanistic cohort study . British Journal of Anaesthesia
Ackland GL, Galley HF, Shelley B, Lambert DG ( 2018 ) . Perioperative medicine and UK plc . British Journal of Anaesthesia
Ackland GL, Abbott TEF, Cain D, Edwards MR, Sultan P, Karmali SN, Fowler AJ, Whittle JR et al. ( 2018 ) . Preoperative systemic inflammation and perioperative myocardial injury: prospective observational multicentre cohort study of patients undergoing non-cardiac surgery . British Journal of Anaesthesia
TORRANCE H, LONGBOTTOM R, VIVIAN M, Lalabekyan B, ABBOTT TEF, ACKLAND GL, HINDS CJ, PEARSE RM et al. ( 2018 ) . Post-operative immune suppression is mediated via reversible, Interleukin-10 dependent pathways in circulating monocytes following major abdominal surgery . PLoS ONE vol. 13 , ( 9 )
Wijeysundera D, PEARSE R, shulman M, ABBOTT TEF, Torres E, Ambosta A, Bernard C, Granton J et al. ( 2018 ) . Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study . Lancet vol. 391 , ( 10140 ) 2631 - 2640 .
WALKER S, ABBOTT TEF, Brown K, PEARSE R, ACKLAND G ( 2018 ) . Perioperative management of angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers: a survey of perioperative medicine practitioners . PeerJ
Lurati Buse G, Manns B, Lamy A, Guyatt G, Polanczyk CA, Chan MTV, Wang CY, Villar JC et al. ( 2018 ) . Troponin T monitoring to detect myocardial injury after noncardiac surgery: a cost–consequence analysis . Canadian Journal of Surgery vol. 61 , ( 3 ) 185 - 194 .
Ackland G, del Arroyo AG, Sanchez J, Patel S, Phillips S, Reyes A, Sultan P, David A ( 2018 ) . Caspase-1 and epidural-related maternal fever . British Journal of Anaesthesia . vol. 120 , e20 - e21 .
ackland GL, ABBOTT T, Pearse RM, Karmali S, Whittle J, Minto G ( 2018 ) . Arterial pulse pressure and postoperative morbidity in high-risk surgical patients . British Journal of Anaesthesia vol. 120 , ( 1 ) 94 - 100 .
Karmali SN, Sciusco A, May SM, Ackland GL ( 2017 ) . Heart rate variability in critical care medicine: a systematic review . Intensive Care Med Exp vol. 5 , ( 1 )
ABBOTT T, pearse RM, Archbold RA, Ahmad T, Niebrzegowska E, Wragg A, Rodseth R, Devereaux PJ et al. ( 2017 ) . A Prospective International Multicentre Cohort Study of Intraoperative Heart Rate and Systolic Blood Pressure and Myocardial Injury After Noncardiac Surgery: Results of the VISION Study . Anesthesia and Analgesia vol. 126 , ( 6 ) 1936 - 1945 .
ACKLAND GL, Minto G, Clark M, Whittle J, Stephens RCM, Owen T, Prabhu P, del Arroyo AG ( 2017 ) . Autonomic regulation of systemic inflammation in humans: a multi-center, blinded observational cohort study . Brain, Behavior, and Immunity
ABBOTT T, pearse R, ahmad T, ackland G ( 2017 ) . Association between preoperative pulse pressure and perioperative myocardial injury: an international observational cohort study of patients undergoing non-cardiac surgery . British Journal Of Anaesthesia vol. 119 , ( 1 ) 78 - 86 .
ABBOTT T, Lee A, Pearse R, Ackland G, Minto G ( 2017 ) . Elevated preoperative heart rate is associated with cardiopulmonary and autonomic impairment in high-risk surgical patients . British Journal Of Anaesthesia vol. 119 , ( 1 ) 87 - 94 .
Patel A, Prowle JR, Ackland GL, POM-O Study Investigators ( 2017 ) . Postoperative goal-directed therapy and development of acute kidney injury following major elective noncardiac surgery: post-hoc analysis of POM-O randomized controlled trial . Clin Kidney J vol. 10 , ( 3 ) 348 - 356 .
Machhada A, Trapp S, Marina N, Stephens RCM, Whittle J, Lythgoe MF, Kasparov S, Ackland GL et al. ( 2017 ) . Vagal determinants of exercise capacity . Nature Communications vol. 8 ,
Biccard BM, Scott DJA, Chan MTV, Archbold A, Wang C-Y, Sigamani A, Urrútia G, Cruz P et al. ( 2017 ) . Myocardial Injury After Noncardiac Surgery (MINS) in Vascular Surgical Patients: A Prospective Observational Cohort Study . Ann Surg
Writing Committee for the VISION Study Investigators, Devereaux PJ, Biccard BM, Sigamani A, Xavier D, Chan MTV, Srinathan SK, Walsh M et al. ( 2017 ) . Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery . JAMA vol. 317 , ( 16 ) 1642 - 1651 .
O'Connor ME, Hewson RW, Kirwan CJ, Ackland GL, Pearse RM, Prowle JR ( 2017 ) . Acute kidney injury and mortality 1 year after major non-cardiac surgery . British Journal of Surgery
Basalay M, Mastitskaya S, Mrochek A, Ackland GL, Arroyo AGD, Sanchez J, Sjoquist P-O, Pernow J et al. ( 2017 ) . Reply: Glucagon-like peptide-1 mediates cardioprotection by remote ischaemic conditioning . Cardiovasc Res vol. 113 , ( 1 ) 13 - 14 .
Basalay MV, Mastitskaya S, Mrochek A, Ackland GL, Del Arroyo AG, Sanchez J, Sjoquist PO, Pernow J et al. ( 2016 ) . Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning . Cardiovascular Research vol. 112 , ( 3 ) 669 - 676 .
Turovsky E, Theparambil SM, Kasymov V, Deitmer JW, Del Arroyo AG, Ackland GL, Corneveaux JJ, Allen AN et al. ( 2016 ) . Mechanisms of CO<inf>2</inf>/H<sup>+</sup> sensitivity of astrocytes . Journal of Neuroscience vol. 36 , ( 42 ) 10750 - 10758 .
Toner A, Jenkins N, Ackland GL ( 2016 ) . Baroreflex impairment and morbidity after major surgery . British Journal of Anaesthesia vol. 117 , ( 3 ) 324 - 331 .
Ackland GL, Whittle J, Toner A, Machhada A, Del Arroyo AG, Sciuso A, Jenkins N, Dyson A et al. ( 2016 ) . Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness . Crit Care Med vol. 44 , ( 8 ) e614 - e624 .
Abbott TEF, Ackland GL, Archbold RA, Wragg A, Kam E, Ahmad T, Khan AW, Niebrzegowska E et al. ( 2016 ) . Preoperative heart rate and myocardial injury after non-cardiac surgery: results of a predefined secondary analysis of the VISION study . British Journal of Anaesthesia vol. 117 , ( 2 ) 172 - 181 .
Ackland GL, Stephens RCM ( 2016 ) . Big Data: A Cheerleader for Translational Perioperative Medicine . Anesth Analg vol. 122 , ( 6 ) 1744 - 1747 .
Sultan P, David AL, Fernando R, Ackland GL ( 2016 ) . Inflammation and Epidural-Related Maternal Fever . Anesthesia & Analgesia vol. 122 , ( 5 ) 1546 - 1553 .
Ackland GL, Mythen MG ( 2016 ) . Physiology of the gastrointestinal tract including splanchnic blood flow and tonometry . Gastrointestinal and Colorectal Anesthesia ,
Wijeysundera DN, Pearse RM, Shulman MA, Abbott TEF, Torres E, Croal BL, Granton JT, Thorpe KE et al. ( 2016 ) . Measurement of Exercise Tolerance before Surgery (METS) study: a protocol for an international multicentre prospective cohort study of cardiopulmonary exercise testing prior to major non-cardiac surgery . BMJ Open vol. 6 , ( 3 ) e010359 - e010359 .
Marina N, Kasymov V, Ackland GL, Kasparov S, Gourine AV ( 2016 ) . Astrocytes and brain hypoxia . vol. 903 , 201 - 207 .
Nelson A, Otto J, Whittle J, Stephens RCM, Martin DS, Prowle JR, Ackland GL ( 2016 ) . Subclinical cardiopulmonary dysfunction in stage 3 chronic kidney disease . Open Heart vol. 3 , ( 1 )
Abbott T, Ackland GL, Wragg A, Rodseth R, Archbold A, Pearse RM ( 2015 ) . Association between intraoperative heart rate and postoperative myocardial injury in patients following non-cardiac surgery . Intensive Care Med Exp vol. 3 , ( Suppl 1 ) A751 - A751 .
Abbott T, Ackland G, Wragg A, Archbold A, Devereaux P, Pearse R ( 2015 ) . Association of preoperative heart rate with postoperative myocardial injury . BRITISH JOURNAL OF ANAESTHESIA . vol. 115 , E958 - E959 .
Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, Trapp S, Tinker A et al. ( 2015 ) . Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve . Heart Rhythm vol. 12 , ( 11 ) 2285 - 2293 .
Karmali S, Jenkins N, Sciusco A, John J, Haddad F, Ackland GL ( 2015 ) . Randomized controlled trial of vagal modulation by sham feeding in elective non-gastrointestinal (orthopaedic) surgery . British Journal of Anaesthesia vol. 115 , ( 5 ) 727 - 735 .
Abbott T, Rodseth R, Le Manach Y, Ackland G, Archbold A, Wragg A, Devereaux P, Pearse R ( 2015 ) . Association between preoperative resting heart rate and postoperative myocardial injury in patients undergoing non-cardiac surgery . ANAESTHESIA . vol. 70 , 28 - 28 .
Milne A, Mon WYU, Down J, Obichere A, Ackland GL ( 2015 ) . Contemporary perioperative management of adult familial dysautonomia (Riley-Day syndrome) . A &amp; A case reports vol. 4 , ( 9 ) 111 - 113 .
Cain DJ, Del Arroyo AG, Ackland GL ( 2015 ) . Man is the new mouse: Elective surgery as a key translational model for multi-organ dysfunction and sepsis . Journal of the Intensive Care Society vol. 16 , ( 2 ) 154 - 163 .
Ackland GL, Cecconi M, Pearse RM ( 2015 ) . Individualised targeted haemodynamic therapy in high-risk surgical patients - authors' reply . The Lancet. Respiratory medicine vol. 3 , ( 4 ) e14 - e15 .
Ackland GL, Prowle JR ( 2015 ) . Presepsin: solving a soluble (CD14) problem in sepsis? . Intensive Care Medicine vol. 41 , ( 2 ) 351 - 353 .
Barsukevich V, Basalay M, Sanchez J, Mrochek A, Whittle J, Ackland GL, Gourine AV, Gourine A ( 2015 ) . Distinct cardioprotective mechanisms of immediate, early and delayed ischaemic postconditioning . Basic Research in Cardiology vol. 110 , ( 1 )
Angelova PR, Kasymov V, Christie I, Sheikhbahaei S, Turovsky E, Marina N, Korsak A, Zwicker J et al. ( 2015 ) . Functional oxygen sensitivity of astrocytes . Journal of Neuroscience vol. 35 , ( 29 ) 10460 - 10473 .
Ackland GL, Iqbal S, Paredes LG, Toner A, Lyness C, Jenkins N, Bodger P, Karmali S et al. ( 2015 ) . Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: A multicentre, randomised, double-blind, controlled, mechanistic trial . The Lancet Respiratory Medicine vol. 3 , ( 1 ) 33 - 41 .
Ackland GL, Igbal S, Paredes LG, Toner A, Lyness C, Jenkins N, Bodger P, Karmali S et al. ( 2015 ) . Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial . LANCET RESPIRATORY MEDICINE vol. 3 , ( 1 ) 33 - 41 .
Edwards MR, Sultan P, del Arroyo AG, Whittle J, Karmali SN, Ramani Moonesinghe S, Haddad FS, Mythen MG et al. ( 2015 ) . Metabolic dysfunction in lymphocytes promotes postoperative morbidity . Clinical Science vol. 129 , ( 5 ) 423 - 437 .
Patel ABU, Reyes A, Ackland GL ( 2015 ) . Non-inferiority of retrospective data collection for assessing perioperative morbidity . PeerJ vol. 2015 , ( 12 )
Whittle J, Nelson A, Otto JM, Stephens RCM, Martin DS, Sneyd JR, Struthers R, Minto G et al. ( 2015 ) . Sympathetic autonomic dysfunction and impaired cardiovascular performance in higher risk surgical patients: implications for perioperative sympatholysis . Open Heart vol. 2 , ( 1 )
Machhada A, Gourine AV, Ackland GL ( 2015 ) . Vagal Modulation of Atrial Fibrillation . Journal of the American College of Cardiology vol. 66 , ( 8 ) 977 - 978 .
Henderson WR, Barnbrook J, Dominelli PB, Griesdale DE, Arndt T, Molgat-Seon Y, Foster G, Ackland GL et al. ( 2014 ) . Administration of intrapulmonary sodium polyacrylate to induce lung injury for the development of a porcine model of early acute respiratory distress syndrome . Intensive Care Med Exp vol. 2 , ( 1 )
Ackland GL, Laing CM ( 2014 ) . Chronic kidney disease: a gateway for perioperative medicine . British Journal of Anaesthesia vol. 113 , ( 6 ) 902 - 905 .
Cain DJ, Del Arroyo AG, Ackland GL ( 2014 ) . Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine . Intensive Care Med Exp vol. 2 , ( 1 )
Machhada A, Ang R, Ninkina N, Buchman VL, Ackland GL, Lythgoe MF, Marina N, Gourine AV ( 2014 ) . A CNS cell group that controls electrical stability of the heart . EUROPEAN HEART JOURNAL . vol. 35 , 435 - 435 .
Machhada A, Gourine AV, Lythgoe MF, Ackland GL ( 2014 ) . Vagal mechanisms controlling exercise capacity . EUROPEAN HEART JOURNAL . vol. 35 , 953 - 953 .
Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MPW, Ahern A et al. ( 2014 ) . Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery a randomized clinical trial and systematic review . JAMA - Journal of the American Medical Association vol. 311 , ( 21 ) 2181 - 2190 .
Botto F, Alonso-Coello P, Chan MTV, Villar JC, Xavier D, Srinathan SK, Guyatt G, Cruz P et al. ( 2014 ) . Myocardial Injury after Noncardiac Surgery: A Large, International, Prospective Cohort Study Establishing Diagnostic Criteria, Characteristics, Predictors, and 30-day Outcomes . Anesthesiology vol. 120 , ( 3 ) 564 - 578 .
Sultan P, Edwards MR, Gutierrez Del Arroyo A, Cain D, Sneyd JR, Struthers R, Minto G, Ackland GL ( 2014 ) . Cardiopulmonary exercise capacity and preoperative markers of inflammation . Mediators of Inflammation vol. 2014 ,
Fragkou PC, Torrance HD, Pearse RM, Ackland GL, Prowle JR, Owen HC, Hinds CJ, O'Dwyer MJ ( 2014 ) . Perioperative blood transfusion is associated with a gene transcription profile characteristic of immunosuppression: a prospective cohort study . Crit Care vol. 18 , ( 5 ) 014 - 0541 .
Abbott T, Ackland GL ( 2014 ) . The relationships between anesthesia . Paradise Lost and the Cosmological Revolution ,
Ackland GL, Kazymov V, Marina N, Singer M, Gourine AV ( 2013 ) . Peripheral neural detection of danger-associated and pathogen-associated molecular patterns . Critical Care Medicine vol. 41 , ( 6 )
Mastitskaya S, Marina N, Gourine A, Gilbey MP, Spyer KM, Teschemacher AG, Kasparov S, Trapp S et al. ( 2012 ) . Cardioprotection evoked by remote ischaemic preconditioning is critically dependent on the activity of vagal pre-ganglionic neurones . Cardiovascular Research vol. 95 , ( 4 ) 487 - 494 .
Pearse RM, Ackland GL ( 2012 ) . Perioperative fluid therapy . Praxis vol. 101 , ( 17 ) 1113 - 1118 .
Pearse RM, Ackland GL ( 2012 ) . Perioperative fluid therapy . BMJ (Online) vol. 344 , ( 7855 )
Ackland GL ( 2012 ) . In response . Anesthesia and Analgesia vol. 114 , ( 3 )
Holm L, Ackland GL, Edwards MR, Breckenridge RA, Sim RB, Offer J ( 2012 ) . Chemical labelling of active serum thioester proteins for quantification . Immunobiology vol. 217 , ( 2 ) 256 - 264 .
Sultan P, Hamilton MA, Ackland GL ( 2012 ) . Preoperative muscle weakness as defined by handgrip strength and postoperative outcomes: A systematic review . BMC Anesthesiology vol. 12 ,
Cain D, Ackland G ( 2012 ) . Knowing the risk? NCEPOD 2011: A wake-up call for perioperative practice . British Journal of Hospital Medicine . vol. 73 , 262 - 264 .
Dyson A, Cone S, Singer M, Ackland GL ( 2012 ) . Microvascular and macrovascular flow are uncoupled in early polymicrobial sepsis . British Journal of Anaesthesia vol. 108 , ( 6 ) 973 - 978 .
Basalay M, Barsukevich V, Mastitskaya S, Mrochek A, Pernow J, Sjöquist PO, Ackland GL, Gourine AV et al. ( 2012 ) . Remote ischaemic pre- and delayed postconditioning - similar degree of cardioprotection but distinct mechanisms . Experimental Physiology vol. 97 , ( 8 ) 908 - 917 .
Edwards M, Whittle J, Ackland GL ( 2011 ) . Biomarkers to guide perioperative management . Postgraduate Medical Journal vol. 87 , ( 1030 ) 542 - 549 .
Ackland GL, Moran N, Cone S, Grocott MPW, Mythen MG ( 2011 ) . Chronic kidney disease and postoperative morbidity after elective orthopedic surgery . Anesthesia and Analgesia vol. 112 , ( 6 ) 1375 - 1381 .
Ackland GL ( 2011 ) . Reply from the authors . British Journal of Anaesthesia vol. 106 , ( 5 )
Ackland GL, Dyson A, Singer M ( 2010 ) . Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest [1] . JAMA - Journal of the American Medical Association vol. 304 , ( 13 )
Barnes SJ, Singer M, Ackland GL ( 2010 ) . DOBUTAMINE STRESS ECHOCARDIOGRAPHY UNMASKS MYOCARDIAL DYSFUNCTION IN EARLY RODENT POLYMICROBIAL SEPSIS . INTENSIVE CARE MEDICINE . vol. 36 , S334 - S334 .
del Arroyo AG, Singer M, Ackland GL ( 2010 ) . NEURO-IMMUNOMODULATION OF HUMAN CD14+CD16+NEUTROPHILS IN SEPSIS . INTENSIVE CARE MEDICINE . vol. 36 , S409 - S409 .
Ackland GL, Edwards M ( 2010 ) . Defining higher-risk surgery . Current Opinion in Critical Care vol. 16 , ( 4 ) 339 - 346 .
Barnes SJ, Ackland GL ( 2010 ) . Beta-adrenoreceptor modulation of metabolic, endocrine and immunologic function during critical illness . Endocrine, Metabolic and Immune Disorders - Drug Targets vol. 10 , ( 3 ) 292 - 300 .
Ackland GL, Yao ST, Rudiger A, Dyson A, Stidwill R, Poputnikov D, Singer M, Gourine AV ( 2010 ) . Cardioprotection, attenuated systemic inflammation, and survival benefit of β1-adrenoceptor blockade in severe sepsis in rats . Critical Care Medicine vol. 38 , ( 2 ) 388 - 394 .
Ackland GL, Gutierrez Del Arroyo A, Yao ST, Stephens RC, Dyson A, Klein NJ, Singer M, Gourine AV ( 2010 ) . Low-molecular-weight polyethylene glycol improves survival in experimental sepsis . Critical Care Medicine vol. 38 , ( 2 ) 629 - 636 .
Ackland GL, Harris S, Ziabari Y, Grocott M, Mythen M ( 2010 ) . Revised cardiac risk index and postoperative morbidity after elective orthopaedic surgery: A prospective cohort study . British Journal of Anaesthesia vol. 105 , ( 6 ) 744 - 752 .
Paschalis A, Churchill L, Marina N, Kasymov V, Gourine A, Ackland G ( 2009 ) . β<inf>1</inf>-Adrenoceptor distribution in the rat brain: An immunohistochemical study . Neuroscience Letters vol. 458 , ( 2 ) 84 - 88 .
Ackland GL, O'Beirne J, Platts AR, Ward SC ( 2008 ) . False-positive presentation of Battle's sign during hepatic encephalopathy . Neurocritical Care vol. 9 , ( 2 ) 253 - 255 .
Ackland GL, Harrington J, Downie P, Holding JW, Singh-Ranger D, Griva K, Mythen MG, Newman SP ( 2008 ) . Dehydration induced by bowel preparation in older adults does not result in cognitive dysfunction . Anesthesia and Analgesia vol. 106 , ( 3 ) 924 - 929 .
Ackland GL, Patterson AJ ( 2007 ) . The pivotal role of beta-adrenoreceptors in critical illness pathophysiology . Yearbook of Intensive Care and Emergency Medicine 2009 ,
Ackland GL, Mythen MG ( 2007 ) . Novel biomarkers in critical care: Utility or futility? . Critical Care vol. 11 , ( 6 )
Ackland GL, Kasymov V, Gourine AV ( 2007 ) . Physiological and pathophysiological roles of extracellular ATP in chemosensory control of breathing . Biochemical Society Transactions vol. 35 , ( 5 ) 1264 - 1268 .
Ackland GL, Scollay JM, Parks RW, De Beaux I, Mythen MG ( 2007 ) . Pre-operative high sensitivity C-reactive protein and postoperative outcome in patients undergoing elective orthopaedic surgery . Anaesthesia vol. 62 , ( 9 ) 888 - 894 .
Ackland GL, Smith M, McGlennan AP ( 2007 ) . Acute, severe hypoglycemia occurring during general anesthesia in a nondiabetic adult [35] . Anesthesia and Analgesia vol. 105 , ( 2 ) 553 - 554 .
Hamilton MA, Mythen MG, Ackland GL ( 2006 ) . Less is not more: A lack of evidence for intraoperative fluid restriction improving outcome after major elective gastrointestinal surgery [15] . Anesthesia and Analgesia vol. 102 , ( 3 ) 970 - 971 .
Spyer KM, Ackland GL, Gourine AV ( 2006 ) . Neurophysiology: Overview . Encyclopedia of Respiratory Medicine, Four-Volume Set ,
Ackland G ( 2006 ) . Perioperative beta-blockade: Beyond myocardial ischaemia . British Journal of Hospital Medicine vol. 67 , ( 5 )
Ackland GL, Fox R ( 2005 ) . Low-dose propofol infusion for controlling acute hyperspasticity after withdrawal of intrathecal baclofen therapy . Anesthesiology vol. 103 , ( 3 ) 663 - 665 .
Ackland GL, Mythen MG ( 2005 ) . Negative pressure pulmonary edema as an unsuspected imitator of acute lung injury/ARDS [10] . Chest vol. 127 , ( 5 ) 1867 - 1868 .
Ackland GL, Singh-Ranger D, Fox S, McClaskey B, Down JF, Farrar D, Sivaloganathan M, Mythen MG ( 2004 ) . Assessment of preoperative fluid depletion using bioimpedence analysis . British Journal of Anaesthesia vol. 92 , ( 1 ) 134 - 136 .
Ackland GL, Gourine AV, Spyer KM ( 2003 ) . Endotoxin impairs the hypoxic ventilatory response in anaesthetized adult rats . INTENSIVE CARE MEDICINE . vol. 29 , S86 - S86 .
Ackland G, Pandit JJ ( 2002 ) . Effect of low-dose volatile anaesthetics on ventilation during acute hypoxia (multiple letters) . Anaesthesia vol. 57 , ( 12 ) 1224 - 1226 .
Ackland G ( 2001 ) . Physical incompatibility between atracurium and intravenous diclofenac . Anaesthesia vol. 56 , ( 3 )
Ackland G, Grocott MPW, Mythen MG ( 2000 ) . Understanding gastrointestinal perfusion in critical care: So near, and yet so far . Critical Care vol. 4 , ( 5 ) 269 - 281 .
Ackland GL, Noble R, Hanson MA ( 1997 ) . Red nucleus inhibits breathing during hypoxia in neonates . Respiration Physiology vol. 110 , ( 2-3 ) 251 - 260 .
Waites BA, Ackland GL, Noble R, Hanson MA ( 1996 ) . Red nucleus lesions abolish the biphasic respiratory response to isocapnic hypoxia in decerebrate young rabbits . Journal of Physiology vol. 495 , ( 1 ) 217 - 225 .
Moore PJ, Ackland GL, Hanson MA ( 1996 ) . Unilateral cooling in the region of locus coeruleus blocks the fall in respiratory output during hypoxia in anaesthetized neonatal sheep . Experimental Physiology vol. 81 , ( 6 ) 983 - 994 .
WAITES BA, ACKLAND GL, NOBLE R, HANSON MA ( 1995 ) . MICROINJECTION OF L-GLUTAMATE IN THE RED NUCLEUS PRODUCES INHIBITION OF RESPIRATORY OUTPUT IN DECEREBRATE NEONATAL RABBITS . JOURNAL OF PHYSIOLOGY-LONDON . vol. 489P , P156 - P156 .
ACKLAND GL, WAITES BA, NOBLE R, HANSON MA ( 1995 ) . BILATERAL LESIONS IN THE RED NUCLEUS ABOLISH THE BIPHASIC RESPIRATORY RESPONSE TO HYPOXIA IN DECEREBRATE NEWBORN RABBITS . JOURNAL OF PHYSIOLOGY-LONDON . vol. 483P , P89 - P89 .
Ackland GL, Moore PJ, Hanson MA ( 1994 ) . Is the ventilatory decline seen in newborns during hypoxaemia centrally mediated? . Advances in Experimental Medicine and Biology vol. 360 , 345 - 348 .
Ackland GL, Moore PJ, Hanson MA ( 1993 ) . Hypoxia inhibits the effect on breathing of transient chemoreceptor stimulation in anaesthetized newborn rabbits . Journal of Physiology . vol. 467 ,