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Research

Publications: Dr Faraz Mardakheh

Heydt Q, Xintaropoulou C, Clear A, Austin M, Pislariu I, Miraki-Moud F, Cutillas P, Korfi K et al. ( 2021 ) . Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence . Nature Communications
Maiques O, Fanshawe B, Crosas-Molist E, Rodriguez-Hernandez I, Volpe A, Cantelli G, Boehme L, Orgaz JL et al. ( 2021 ) . A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma . British Journal of Cancer vol. 125 , ( 5 ) 699 - 713 .
Mendoza MB, Gutierrez S, Ortiz R, Moreno DF, Dermit M, Dodel M, Rebollo E, Bosch M et al. ( 2021 ) . The elongation factor eEF1A2 controls translation and actin dynamics in dendritic spines . Science Signaling vol. 14 , ( 691 )
Dermit M, Mardakheh FK ( 2021 ) . Purification and quantitative proteomic analysis of cell bodies and protrusions . STAR Protocols vol. 2 , ( 2 )
Fish L, Khoroshkin M, Navickas A, Garcia K, Culbertson B, Hanisch B, Zhang S, Nguyen HCB et al. ( 2021 ) . A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements . Science vol. 372 , ( 6543 )
Adams SD, Csere J, D'angelo G, Carter EP, Romao M, Arnandis T, Dodel M, Kocher HM et al. ( 2021 ) . Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption . Current Biology vol. 31 , ( 7 ) 1403 - 1416.e7 .
DERMIT M, Dodel M, Lee F, Azman M, Schwenzer H, Jones JJL, Blagden S, Ule J et al. ( 2020 ) . Subcellular mRNA localization regulates ribosome biogenesis in migrating cells . Developmental Cell vol. 55 , ( 3 ) 298 - 313 .
Hau HTA, Ogundele O, Hibbert AH, Monfries CAL, Exelby K, Wood NJ, Nevarez-Mejia J, Carbajal MA et al. ( 2020 ) . Maternal Larp6 controls oocyte development, chorion formation and elevation . Development (Cambridge) vol. 147 , ( 4 )
Yu J, Navickas A, Asgharian H, Culbertson B, Fish L, Garcia K, Olegario JP, Dermit M et al. ( 2020 ) . Rbms1 suppresses colon cancer metastasis through targeted stabilization of its mRNA regulon . Cancer Discovery vol. 10 , ( 9 ) 1410 - 1423 .
Touat M, Sourisseau T, Dorvault N, Chabanon RM, Garrido M, Morel D, Krastev DB, Bigot L et al. ( 2018 ) . DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade . Journal of Clinical Investigation vol. 128 , ( 4 ) 1671 - 1687 .
Mardakheh FK ( 2017 ) . Mass spectrometry analysis of spatial protein networks by colocalization analysis (COLA) . Methods in Molecular Biology , vol. 1636 ,
Dermit M, Dodel M, Mardakheh FK ( 2017 ) . Methods for monitoring and measurement of protein translation in time and space . Molecular BioSystems vol. 13 , ( 12 ) 2477 - 2488 .
Mardakheh FK, Self A, Marshall CJ ( 2017 ) . RHO binding to FAM65A regulates Golgi reorientation during cell migration . Development vol. 144 , ( 1 ) e1.1 - e1.1 .
Mardakheh FK, Self A, Marshall CJ ( 2016 ) . RHO binding to FAM65A regulates Golgi reorientation during cell migration . J Cell Sci vol. 129 , ( 24 ) 4466 - 4479 .
Touat M, Olaussen K, Sourisseau T, Friboulet L, Dorvault N, Enot D, Bigot L, Pontoizeau C et al. ( 2016 ) . 154 NAMPT inhibition is a novel synthetic lethal therapeutic approach exploiting nuclear–mitochondrial crosstalk in ERCC1-deficient populations . European Journal of Cancer . vol. 69 ,
Mardakheh FK, Sailem HZ, Kümper S, Tape CJ, McCully RR, Paul A, Anjomani-Virmouni S, Jørgensen C et al. ( 2016 ) . Proteomics profiling of interactome dynamics by colocalisation analysis (COLA) . Mol Biosyst vol. 13 , ( 1 ) 92 - 105 .
Natrajan R, Sailem H, Mardakheh FK, Arias Garcia M, Tape CJ, Dowsett M, Bakal C, Yuan Y ( 2016 ) . Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology–Genomic Integration Analysis . PLoS Medicine vol. 13 , ( 2 )
Kümper S, Mardakheh FK, McCarthy A, Yeo M, Stamp GW, Paul A, Worboys J, Sadok A et al. ( 2016 ) . Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis . eLife vol. 5 , ( JANUARY2016 )
Mardakheh FK, Paul A, Kümper S, Sadok A, Paterson H, Mccarthy A, Yuan Y, Marshall CJ ( 2015 ) . Global Analysis of mRNA, Translation, and Protein Localization: Local Translation Is a Key Regulator of Cell Protrusions . Developmental Cell vol. 35 , ( 3 ) 344 - 357 .
Sadok A, McCarthy A, Caldwell J, Collins I, Garrett MD, Yeo M, Hooper S, Sahai E et al. ( 2015 ) . Rho kinase inhibitors block melanoma cell migration and inhibit metastasis . Cancer Research vol. 75 , ( 11 ) 2272 - 2284 .
Mardakheh FK, Auciello G, Dafforn TR, Rappoport JZ, Heath JK ( 2010 ) . Nbr1 is a novel inhibitor of ligand-mediated receptor tyrosine kinase degradation . Molecular and Cellular Biology vol. 30 , ( 24 ) 5672 - 5685 .
Mardakheh FK, Yekezare M, Machesky LM, Heath JK ( 2009 ) . Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling . Journal of Cell Biology vol. 187 , ( 2 ) 265 - 277 .
Sweet SMM, Mardakheh FK, Ryan KJP, Langton AJ, Heath JK, Cooper HJ ( 2008 ) . Targeted online liquid chromatography electron capture dissociation mass spectrometry for the localization of sites of in vivo phosphorylation in human Sprouty2 . Analytical Chemistry vol. 80 , ( 17 ) 6650 - 6657 .
Mardakheh FK, Yekezare M, Machesky LM, Heath JK ( 2008 ) . SPRED redirects activated receptors to lysosomes via scaffolding protein NBR1 . European Journal of Cancer Supplements . vol. 6 , 38 - 39 .
Akbarzadeh S, Wheldon LM, Sweet SMM, Talma S, Mardakheh FK, Heath JK ( 2008 ) . The deleted in Brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src . PLoS ONE vol. 3 , ( 3 )