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Research

Publications: Mr Barrie Peck

Heydt Q, Xintaropoulou C, Clear A, Austin M, Pislariu I, Miraki-Moud F, Cutillas P, Korfi K et al. ( 2021 ) . Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence . Nature Communications
Peck B, Bland P, Mavrommati I, Muirhead G, Cottom H, Wai PT, Maguire SL, Barker HE et al. ( 2021 ) . 3D functional genomics screens identify CREBBP as a targetable driver in aggressive triple-negative breast cancer . Cancer Research vol. 81 , ( 4 ) 847 - 859 .
Kapara A, Vannini A, Peck B ( 2020 ) . A micronutrient with major effects on cancer cell viability . Nature Metabolism
Peck B, Schulze A ( 2019 ) . Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment . Trends in Cancer vol. 5 , ( 11 ) 693 - 703 .
Jones DT, Valli A, Haider S, Zhang Q, Smethurst EA, Schug ZT, Peck B, Aboagye EO et al. ( 2018 ) . 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers . Molecular Cancer Therapeutics vol. 18 , ( 2 ) 376 - 388 .
Miess H, Dankworth B, Gouw AM, Rosenfeldt M, Schmitz W, Jiang M, Saunders B, Howell M et al. ( 2018 ) . The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma . Oncogene vol. 37 , ( 40 ) 5435 - 5450 .
Leonidou A, Peck B, Natrajan R ( 2017 ) . Identification and validation of driver kinases from next-generation sequencing data . vol. 1636 , 179 - 195 .
Morrison E, Wai P, Leonidou A, Bland P, Khalique S, Farnie G, Daley F, Peck B et al. ( 2016 ) . Utilizing functional genomics screening to identify potentially novel drug targets in cancer cell spheroid cultures . Journal of Visualized Experiments vol. 2016 , ( 118 ) 1 - 8 .
Maguire SL, Peck B, Wai PT, Campbell J, Barker H, Gulati A, Daley F, Vyse S et al. ( 2016 ) . Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model . Journal of Pathology vol. 240 , ( 3 ) 315 - 328 .
Peck B, Schulze A ( 2016 ) . Lipid desaturation – the next step in targeting lipogenesis in cancer? . FEBS Journal2767 - 2778 .
Peck B, Schug ZT, Zhang Q, Dankworth B, Jones DT, Smethurst E, Patel R, Mason S et al. ( 2016 ) . Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments . Cancer Metab vol. 4 ,
Lewis CA, Brault C, Peck B, Bensaad K, Griffiths B, Mitter R, Chakravarty P, East P et al. ( 2015 ) . SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme . Oncogene vol. 34 , ( 40 ) 5128 - 5140 .
Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E et al. ( 2015 ) . Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress . Cancer Cell vol. 27 , ( 1 ) 57 - 71 .
Peck B, Schulze A ( 2014 ) . Cholesteryl esters: Fueling the fury of prostate cancer . Cell Metabolism vol. 19 , ( 3 ) 350 - 352 .
Schug Z, Peck B, Jones D, Zhang Q, Alam I, Witney T, Smethurst E, Grosskurth S et al. ( 2014 ) . Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress . Cancer & metabolism vol. 2 , ( Suppl 1 ) O9 - O9 .
Bensaad K, Favaro E, Lewis CA, Peck B, Lord S, Collins JM, Pinnick KE, Wigfield S et al. ( 2014 ) . Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation . Cell Reports vol. 9 , ( 1 ) 349 - 365 .
Peck B, Ferber EC, Schulze A ( 2013 ) . Antagonism between FOXO and MYC regulates cellular powerhouse . Frontiers in Oncology vol. 3 APR ,
Baenke F, Peck B, Miess H, Schulze A ( 2013 ) . Hooked on fat: The role of lipid synthesis in cancer metabolism and tumour development . DMM Disease Models and Mechanisms vol. 6 , ( 6 ) 1353 - 1363 .
Griffiths B, Lewis CA, Bensaad K, Ros S, Zhang Q, Ferber EC, Konisti S, Peck B et al. ( 2013 ) . Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth . Cancer Metab vol. 1 , ( 1 )
Ferber EC, Peck B, Delpuech O, Bell GP, East P, Schulze A ( 2012 ) . FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression . Cell Death and Differentiation vol. 19 , ( 6 ) 968 - 979 .
Peck B, Schulze A ( 2011 ) . A role for the cancer-associated miR-106b~25 cluster in neuronal stem cells . Aging vol. 3 , ( 4 ) 329 - 331 .
Peck B, Chen CY, Ho KK, Di Fruscia P, Myatt SS, Charles Coombes R, Fuchter MJ, Hsiao CD et al. ( 2010 ) . SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2 . Molecular Cancer Therapeutics vol. 9 , ( 4 ) 844 - 855 .
Kwok JMM, Peck B, Monteiro LJ, Schwenen HDC, Millour J, Coombes RC, Myatt SS, Lam EWF ( 2010 ) . FOXM1 confers acquired cisplatin resistance in breast cancer cells . Molecular Cancer Research vol. 8 , ( 1 ) 24 - 34 .
Francis RE, Myatt SS, Krol J, Hartman J, Peck B, McGovern UB, Wang J, Guest SK et al. ( 2009 ) . FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer . International Journal of Oncology vol. 35 , ( 1 ) 57 - 68 .
McGovern UB, Francis RE, Peck B, Guest SK, Wang J, Myatt SS, Krol J, Kwok JMM et al. ( 2009 ) . Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer . Molecular Cancer Therapeutics vol. 8 , ( 3 ) 582 - 591 .