Publications: Dr Barrie Peck

Bland P, Saville H, Wai PT, Curnow L, Nieminuszczy J, Ravindran N, Barker HE, Wright J et al. ( 2023 ) . Abstract B020: SF3B1  hotspot mutations confer sensitivity to PARP inhibition through a defective replication stress response . Molecular Cancer Therapeutics vol. 22 , ( 12_Supplement ) b020 - b020 .

Bland P, Saville H, Wai PT, Curnow L, Muirhead G, Nieminuszczy J, Ravindran N, John MB et al. ( 2023 ) . SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response . Nature Genetics vol. 55 , ( 8 ) 1311 - 1323 .

Gibson SV, Tomas Bort E, Rodríguez-Fernández L, Allen MD, Gomm JJ, Goulding I, auf dem Keller U, Agnoletto A et al. ( 2023 ) . TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression . npj Breast Cancer vol. 9 , ( 1 )

Bland P, Saville H, Read A, Wai P, Muirhead G, Curnow L, Nieminuszczy J, Ravindran N et al. ( 2023 ) . Abstract P6-10-05: Mutations in the RNA Splicing Factor SF3B1 drive endocrine therapy resistance and confer a targetable replication stress response defect through PARP inhibition . Cancer Research vol. 83 , ( 5_Supplement )

Dembitz V, Lawson H, Philippe C, Burt RJ, James S, Magee ASM, Woodley K, Durko J et al. ( 2022 ) . Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid Leukemia . Blood vol. 140 , ( Supplement 1 ) 3058 - 3060 .

Heydt Q, Xintaropoulou C, Clear A, Austin M, Pislariu I, Miraki-Moud F, Cutillas P, Korfi K et al. ( 2021 ) . Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence . Nature Communications

Peck B, Bland P, Mavrommati I, Muirhead G, Cottom H, Wai PT, Maguire SL, Barker HE et al. ( 2021 ) . 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer . Cancer Research vol. 81 , ( 4 ) 847 - 859 .

Kapara A, Vannini A, Peck B ( 2020 ) . A micronutrient with major effects on cancer cell viability . Nature Metabolism

Peck B, Schulze A ( 2019 ) . Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment . Trends in Cancer vol. 5 , ( 11 ) 693 - 703 .

Jones DT, Valli A, Haider S, Zhang Q, Smethurst EA, Schug ZT, Peck B, Aboagye EO et al. ( 2018 ) . 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers . Molecular Cancer Therapeutics vol. 18 , ( 2 ) 376 - 388 .

Peck B, Bland PJ, Wai PT, Cottom H, Maguire SL, Morrison E, Barker HE, Kriplani D et al. ( 2018 ) . Abstract 788: Modeling tumor microenvironmental heterogeneity identifies CREBBP as a novel tumor suppressor in breast cancer . Cancer Research vol. 78 , ( 13_Supplement ) 788 - 788 .

Miess H, Dankworth B, Gouw AM, Rosenfeldt M, Schmitz W, Jiang M, Saunders B, Howell M et al. ( 2018 ) . The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma . Oncogene vol. 37 , ( 40 ) 5435 - 5450 .

Leonidou A, Peck B, Natrajan R ( 2017 ) . Identification and Validation of Driver Kinases from Next-Generation Sequencing Data . vol. 1636 , 179 - 195 .

Khalique S, Williamson CT, Pemberton H, Wai PT, Menon M, Brough R, Leonidou A, Peck B et al. ( 2017 ) . Abstract NTOC-093: SYNTHETIC LETHAL APPROACHES TO TARGET ARID1A DEFICIENT OVARIAN CANCERS . Clinical Cancer Research vol. 23 , ( 11_Supplement )

Morrison E, Wai P, Leonidou A, Bland P, Khalique S, Farnie G, Daley F, Peck B et al. ( 2016 ) . Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures . Journal of Visualized Experiments ( 118 )

Maguire SL, Peck B, Wai PT, Campbell J, Barker H, Gulati A, Daley F, Vyse S et al. ( 2016 ) . Three‐dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model . The Journal of Pathology vol. 240 , ( 3 ) 315 - 328 .

Leonidou A, Maguire SL, Wai PT, Huang P, Peck B, Natrajan RC ( 2016 ) . 130 Functional assessment of low-frequency mutations in breast cancer . European Journal of Cancer vol. 61 ,

Peck B, Maguire S, Morrison E, Wai P, Natrajan R ( 2016 ) . 362 Modelling the tumour microenvironment and employing functional genomics identifies CREBBP as a novel tumour suppressor in triple negative breast cancers . European Journal of Cancer vol. 61 , s73 - s74 .

Peck B, Schug ZT, Zhang Q, Dankworth B, Jones DT, Smethurst E, Patel R, Mason S et al. ( 2016 ) . Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments . Cancer & Metabolism vol. 4 , ( 1 )

Peck B, Schulze A ( 2016 ) . Lipid desaturation – the next step in targeting lipogenesis in cancer? . The FEBS Journal vol. 283 , ( 15 ) 2767 - 2778 .

Peck B, Maguire S, Morrison E, Wai P, Natrajan R ( 2016 ) . Abstract PR06: Modeling the tumor microenvironment to identify novel loss of function mutations in breast cancer progression . Molecular Cancer Research vol. 14 , ( 2_Supplement ) pr06 - pr06 .

Lewis CA, Brault C, Peck B, Bensaad K, Griffiths B, Mitter R, Chakravarty P, East P et al. ( 2015 ) . SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme . Oncogene vol. 34 , ( 40 ) 5128 - 5140 .

Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E et al. ( 2015 ) . Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress . Cancer Cell vol. 27 , ( 1 ) 57 - 71 .

Bensaad K, Favaro E, Lewis CA, Peck B, Lord S, Collins JM, Pinnick KE, Wigfield S et al. ( 2014 ) . Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation . Cell Reports vol. 9 , ( 1 ) 349 - 365 .

Schug Z, Peck B, Jones D, Zhang Q, Alam I, Witney T, Smethurst E, Grosskurth S et al. ( 2014 ) . Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress . Cancer & Metabolism vol. 2 , ( Suppl 1 )

Peck B, Schulze A ( 2014 ) . Cholesteryl Esters: Fueling the Fury of Prostate Cancer . Cell Metabolism vol. 19 , ( 3 ) 350 - 352 .

Baenke F, Peck B, Miess H, Schulze A ( 2013 ) . Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development . Disease Models & Mechanisms vol. 6 , ( 6 ) 1353 - 1363 .

Griffiths B, Lewis CA, Bensaad K, Ros S, Zhang Q, Ferber EC, Konisti S, Peck B et al. ( 2013 ) . Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth . Cancer & Metabolism vol. 1 , ( 1 )

Peck B, Ferber EC, Schulze A ( 2013 ) . Antagonism between FOXO and MYC Regulates Cellular Powerhouse . Frontiers in Oncology vol. 3 ,

Ferber EC, Peck B, Delpuech O, Bell GP, East P, Schulze A ( 2011 ) . FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression . Cell Death & Differentiation vol. 19 , ( 6 ) 968 - 979 .

Peck B, Schulze A ( 2011 ) . A role for the cancer-associated miR-106b~25 cluster in neuronal stem cells . Aging vol. 3 , ( 4 ) 329 - 331 .

Peck B, Chen C-Y, Ho K-K, Di Fruscia P, Myatt SS, Coombes RC, Fuchter MJ, Hsiao C-D et al. ( 2010 ) . SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2 . Molecular Cancer Therapeutics vol. 9 , ( 4 ) 844 - 855 .

Kwok JM-M, Peck B, Monteiro LJ, Schwenen HDC, Millour J, Coombes RC, Myatt SS, Lam EW-F ( 2010 ) . FOXM1 Confers Acquired Cisplatin Resistance in Breast Cancer Cells . Molecular Cancer Research vol. 8 , ( 1 ) 24 - 34 .

Francis RE, Myatt SS, Krol J, Hartman J, Peck B, McGovern UB, Wang J, Guest SK et al. ( 2009 ) . FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer . International Journal of Oncology vol. 35 , ( 1 ) 57 - 68 .

McGovern UB, Francis RE, Peck B, Guest SK, Wang J, Myatt SS, Krol J, Kwok JM-M et al. ( 2009 ) . Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer . Molecular Cancer Therapeutics vol. 8 , ( 3 ) 582 - 591 .