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Research

Publications:  Ioanna Keklikoglou

Martinez-Usatorre A, Kadioglu E, Boivin G, Cianciaruso C, Guichard A, Torchia B, Zangger N, Nassiri S et al. ( 2021 ) . Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models . Science Translational Medicine vol. 13 , ( 606 )
Martinez-Usatorre A, Kadioglu E, Cianciaruso C, Guichard A, Torchia B, Nassiri S, Schmittnaegel M, Ries CH et al. ( 2021 ) . Abstract 75: Determinants of tumor resistance to anti-angiogenic immunotherapy in mouse models of Kras-mutant NSCLC . 75 - 75 .
Martinez-Usatorre A, Kadioglu E, Cianciaruso C, Guichard A, Torchia B, Nassiri S, Schmittnaegel M, Ries CH et al. ( 2021 ) . Determinants of tumor resistance to anti-angiogenic immunotherapy in mouse models of Krasmutant NSCLC . CANCER RESEARCH . vol. 81 ,
Martinez-Usatorre A, Kadioglu E, Cianciaruso C, Torchia B, Faget J, Meylan E, Schmittnaegel M, Keklikoglou I et al. ( 2020 ) . O4 Mechanisms of lung cancer hyper-progression promoted by PD-1 immune checkpoint blockade . Journal for ImmunoTherapy of Cancer vol. 8 , ( Suppl 2 ) a5.1 - a5a5 .
Mansouri N, Keklikoglou I, Nassiri S, Torchia B, Guichard A, De Palma M ( 2020 ) . Role of extracellular vesicles in chemotherapy-induced lung metastasis .
Keklikoglou I, Cianciaruso C, Güç E, Squadrito ML, Spring LM, Tazzyman S, Lambein L, Poissonnier A et al. ( 2019 ) . Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models . Nature Cell Biology vol. 21 , ( 2 ) 190 - 202 .
Keklikoglou I, Kadioglu E, Bissinger S, Langlois B, Bellotti A, Orend G, Ries CH, De Palma M ( 2018 ) . Periostin Limits Tumor Response to VEGFA Inhibition . Cell Reports vol. 22 , ( 10 ) 2530 - 2540 .
Bissinger S, Schmittnaegel M, Keklikoglou I, De Palma M, Hoves S, Ries C ( 2017 ) . CSF1/CSF1R signaling blockade triggers release of matrix-degrading proteases in mouse models . JOURNAL FOR IMMUNOTHERAPY OF CANCER . vol. 5 ,
Keklikoglou I, Hosaka K, Bender C, Bott A, Koerner C, Mitra D, Will R, Woerner A et al. ( 2015 ) . MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes . Oncogene vol. 34 , ( 37 ) 4867 - 4878 .
Hughes R, Qian BZ, Rowan C, Muthana M, Keklikoglou I, Olson OC, Tazzyman S, Danson S et al. ( 2015 ) . Perivascular M2 macrophages stimulate tumor relapse after chemotherapy . Cancer Research vol. 75 , ( 17 ) 3479 - 3491 .
Shukla K, Sharma AK, Ward A, Will R, Hielscher T, Balwierz A, Breunig C, Münstermann E et al. ( 2015 ) . MicroRNA-30c-2-3p negatively regulates NF-κB signaling and cell cycle progression through downregulation of TRADD and CCNE1 in breast cancer . Molecular Oncology vol. 9 , ( 6 ) 1106 - 1119 .
Russell H, Qian B, Keklikoglou I, Oakley O, Muthana M, De Palma M, Joyce J, Pollard J et al. ( 2015 ) . A distinct subset of perivascular macrophages drive tumour relapse after chemotherapy . CLINICAL & EXPERIMENTAL METASTASIS . vol. 32 , 184 - 184 .
Keklikoglou I, De Palma M ( 2014 ) . Cancer: Metastasis risk after anti-macrophage therapy . Nature vol. 515 , ( 7525 ) 46 - 47 .
Rigamonti N, Kadioglu E, Keklikoglou I, Rmili CW, Leow CC, de Palma M ( 2014 ) . Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade . Cell Reports vol. 8 , ( 3 ) 696 - 706 .
Wiemann S, Bott A, Keklikoglou I, Giacomelli C, Balwierz A, Uhlmann S, Mannsperger H, Korf U et al. ( 2014 ) . 53: miRNA-protein interaction networks in cancer . European Journal of Cancer . vol. 50 ,
Keklikoglou I, De Palma M ( 2014 ) . Vascular modulatory functions of macrophages . Macrophages: Biology and Role in the Pathology of Diseases ,
Keklikoglou I, Ward A ( 2014 ) . MIR373 (microRNA 373) . Atlas of Genetics and Cytogenetics in Oncology and Haematology ( 3 )
Wiemann S, Keklikoglou I, Uhlmann S, Giacomelli C, Mannsperger H, Korf U ( 2014 ) . SP-0606: miRNA-protein interaction networks in cancer . Radiotherapy and Oncology vol. 111 ,
Garding A, Bhattacharya N, Claus R, Ruppel M, Tschuch C, Filarsky K, Idler I, Zucknick M et al. ( 2013 ) . Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a Gene Cluster That Targets NF-kB . PLoS Genetics vol. 9 , ( 4 )
Körner C, Keklikoglou I, Bender C, Wörner A, Münstermann E, Wiemann S ( 2013 ) . MicroRNA-31 sensitizes human breast cells to apoptosis by direct targeting of protein kinase C ε (PKCε) . Journal of Biological Chemistry vol. 288 , ( 12 ) 8750 - 8761 .
Keklikoglou I, Koerner C, Schmidt C, Zhang JD, Heckmann D, Shavinskaya A, Allgayer H, Gückel B et al. ( 2012 ) . MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-B and TGF-Β signaling pathways . Oncogene vol. 31 , ( 37 ) 4150 - 4163 .
Mertens D, Bhattacharya N, Garding A, Claus R, Zucknick M, Filarsky K, Keklikoglou I, Idler I et al. ( 2012 ) . EPIGENETIC UPREGULATION OF LNCRNAS AT 13Q14.3 IN LEUKEMIA CORRELATES WITH DOWNREGULATION IN CIS OF A GENE CLUSTER REGULATING NF-KB . HAEMATOLOGICA . vol. 97 , 450 - 450 .
Jurmeister S, Baumann M, Balwierz A, Keklikoglou I, Ward A, Uhlmann S, Zhang JD, Wiemann S et al. ( 2012 ) . MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F . Molecular and Cellular Biology vol. 32 , ( 3 ) 633 - 651 .
Gorska K, Keklikoglou I, Tschulena U, Winssinger N ( 2011 ) . Rapid fluorescence imaging of miRNAs in human cells using templated Staudinger reaction . Chemical Science vol. 2 , ( 10 ) 1969 - 1975 .
Zhang JD, Koerner C, Bechtel S, Bender C, Keklikoglou I, Schmidt C, Irsigler A, Ernst U et al. ( 2011 ) . Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation . PLoS ONE vol. 6 , ( 7 )
Tschulena U, Keklikoglou I, Horwedel C, Zhang D, Diederichs S, Wiemann S ( 2010 ) . 684 A novel large-scale screen to identify modulators of oncomir miR-21 . European Journal of Cancer Supplements . vol. 8 ,
Arrizubieta MJ, Kanata E, Keklikoglou I, Papasavva-Stylianou P, Toumazos P, Panagiotidis CH, Sklaviadis T ( 2009 ) . Design and validation of a high-throughput assay to detect codon 146 polymorphisms in the caprine prion protein gene . Analytical Biochemistry vol. 393 , ( 2 ) 229 - 233 .