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Research

Publications: Dr Miguel Ganuza Fernandez

Ganuza M, Hall T, Obeng EA, McKinney-Freeman S ( 2020 ) . Clones assemble! The clonal complexity of blood during ontogeny and disease . Experimental Hematology vol. 83 , 35 - 47 .
Ganuza M, Hall T, Finkelstein D, Wang Y-D, Chabot A, Kang G, Bi W, Wu G et al. ( 2019 ) . The global clonal complexity of the murine blood system declines throughout life and after serial transplantation . Blood vol. 133 , ( 18 ) 1927 - 1942 .
Ganuza M, Chabot A, Tang X, Bi W, Natarajan S, Carter R, Gawad C, Kang G et al. ( 2018 ) . Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs . Nature Communications vol. 9 , ( 1 ) 5405 - 5405 .
Hall T, Walker M, Ganuza M, Holmfeldt P, Bordas M, Kang G, Bi W, Palmer LE et al. ( 2018 ) . Nfix Promotes Survival of Immature Hematopoietic Cells via Regulation of c-Mpl . Stem Cells vol. 36 , ( 6 ) 943 - 950 .
Ganuza M, Hall T, Finkelstein D, Chabot A, Kang G, McKinney-Freeman S ( 2017 ) . Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny . Nat Cell Biol vol. 19 , ( 10 ) 1153 - 1163 .
Ganuza M, McKinney-Freeman S ( 2017 ) . Hematopoietic stem cells under pressure . Curr Opin Hematol vol. 24 , ( 4 ) 314 - 321 .
Ganuza M, Hadland B, Chabot A, Li C, Kang G, Bernstein I, McKinney-Freeman S ( 2017 ) . Murine hemogenic endothelial precursors display heterogeneous hematopoietic potential ex vivo . Exp Hematol vol. 51 , 25 - 35.e6 .
Holmfeldt P, Ganuza M, Marathe H, He B, Hall T, Kang G, Moen J, Pardieck J et al. ( 2016 ) . Functional screen identifies regulators of murine hematopoietic stem cell repopulation . J Exp Med vol. 213 , ( 3 ) 433 - 449 .
Ganuza Fernandez M, Holmfeldt P, Marathe H, Hall T, Pardieck J, McKinney-Freeman S ( 2014 ) . Functional Screen Identifies Novel Regulators of Murine Hematopoietic Stem Cell Engraftment . Blood vol. 124 , ( 21 ) 4321 - 4321 .
Ganuza M, Santamaría D ( 2012 ) . Cdk7: open questions beyond the prevailing model . Cell Cycle vol. 11 , ( 19 ) 3519 - 3520 .
Ganuza M, Sáiz-Ladera C, Cañamero M, Gómez G, Schneider R, Blasco MA, Pisano D, Paramio JM et al. ( 2012 ) . Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion . EMBO J vol. 31 , ( 11 ) 2498 - 2510 .