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Research

Publications: Dr Andrew Finch

Masalmeh RHA, Taglini F, Rubio-Ramon C, Musialik KI, Higham J, Davidson-Smith H, Kafetzopoulos I, Pawlicka KP et al. ( 2021 ) . De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands . Nature Communications vol. 12 , ( 1 )
Finch AJ, Baena E ( 2021 ) . Spatiofunctional dynamics of nkx3.1 to safeguard the prostate from cancer . Cancer Discovery vol. 11 , ( 9 ) 2132 - 2134 .
Watts ER, Howden AJM, Morrison T, Sadiku P, Hukelmann J, Von Kriegsheim A, Ghesquiere B, Murphy F et al. ( 2021 ) . Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism . Journal of Clinical Investigation vol. 131 , ( 10 )
Hajeyah AA, Griffiths WJ, Wang Y, Finch AJ, O’Donnell VB ( 2020 ) . The Biosynthesis of Enzymatically Oxidized Lipids . Frontiers in Endocrinology vol. 11 , 591819 - 591819 .
Sirey TM, Roberts K, Haerty W, Bedoya-Reina O, Rogatti-Granados S, Tan JY, Li N, Heather LC et al. ( 2019 ) . Erratum: Correction: The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity (eLife (2019) 8 PII: e50980) . eLife vol. 8 ,
Pantazi A, Quintanilla A, Hari P, Tarrats N, Parasyraki E, Dix FL, Patel J, Chandra T et al. ( 2019 ) . Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence . Aging Cell vol. 18 , ( 4 )
Hari P, Millar FR, Tarrats N, Birch J, Quintanilla A, Rink CJ, Fernández-Duran I, Muir M et al. ( 2019 ) . The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype . Science Advances vol. 5 , ( 6 )
Sirey TM, Roberts K, Haerty W, Bedoya-Reina O, Granados SR, Tan JY, Li N, Heather LC et al. ( 2019 ) . The long non-coding rna cerox1 is a post transcriptional regulator of mitochondrial complex i catalytic activity . eLife vol. 8 ,
Handley MT, Reddy K, Wills J, Rosser E, Kamath A, Halachev M, Falkous G, Williams D et al. ( 2019 ) . ITPase deficiency causes a martsolf-like syndrome with a lethal infantile dilated cardiomyopathy . PLoS Genetics vol. 15 , ( 3 )
Guitart AV, Finch AJ, Kranc KR ( 2018 ) . Ca<sup>2+</sup>tapulting HSCs into action . Journal of Experimental Medicine vol. 215 , ( 8 ) 1971 - 1973 .
Wills J, Edwards-Hicks J, Finch AJ ( 2017 ) . AssayR: A Simple Mass Spectrometry Software Tool for Targeted Metabolic and Stable Isotope Tracer Analyses . Analytical Chemistry vol. 89 , ( 18 ) 9616 - 9619 .
Yeyati PL, Schiller R, Mali G, Kasioulis I, Kawamura A, Adams IR, Playfoot C, Gilbert N et al. ( 2017 ) . KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability . Journal of Cell Biology vol. 216 , ( 4 ) 999 - 1013 .
Guitart AV, Panagopoulou TI, Villacreces A, Vukovic M, Sepulveda C, Allen L, Carter RN, van de Lagemaat LN et al. ( 2017 ) . Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions . The Journal of experimental medicine vol. 214 , ( 3 ) 719 - 735 .
Meehan J, Ward C, Turnbull A, Bukowski-Wills J, Finch AJ, Jarman EJ, Xintaropoulou C, Martinez-Perez C et al. ( 2017 ) . Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells . Oncotarget vol. 8 , ( 26 ) 42857 - 42875 .
Gammoh N, Fraser J, Puente C, Syred HM, Kang H, Ozawa T, Lam D, Acosta JC et al. ( 2016 ) . Suppression of autophagy impedes glioblastoma development and induces senescence . Autophagy vol. 12 , ( 9 ) 1431 - 1439 .
Byrne KM, Monsefi N, Dawson JC, Degasperi A, Bukowski-Wills JC, Volinsky N, Dobrzyński M, Birtwistle MR et al. ( 2016 ) . Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches . Cell Systems vol. 2 , ( 1 ) 38 - 48 .
Guitart AV, Vukovic M, Sas Z, Vila M, Sepulveda C, Panagopoulou T, Allen L, Pollard P et al. ( 2015 ) . FUMARATE HYDRATASE IS AN ESSENTIAL REGULATOR OF EMBRYONIC AND ADULT HAEMATOPOIETIC STEM CELL . HAEMATOLOGICA . vol. 100 , 123 - 123 .
Rainger J, Pehlivan D, Johansson S, Bengani H, Sanchez-Pulido L, Williamson KA, Ture M, Barker H et al. ( 2014 ) . Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations . American Journal of Human Genetics vol. 94 , ( 6 ) 915 - 923 .
Kasioulis I, Syred HM, Tate P, Finch A, Shaw J, Seawright A, Fuszard M, Botting CH et al. ( 2014 ) . Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis . Molecular Biology of the Cell vol. 25 , ( 8 ) 1216 - 1233 .
Hilcenko C, Simpson PJ, Finch AJ, Bowler FR, Churcher MJ, Jin L, Packman LC, Shlien A et al. ( 2013 ) . Aberrant 3′ oligoadenylation of spliceosomal U6 small nuclear RNA in poikiloderma with neutropenia . Blood vol. 121 , ( 6 ) 1028 - 1038 .
Lutzny G, Kocher T, Schmidt-Supprian M, Rudelius M, Klein-Hitpass L, Finch AJ, Dürig J, Wagner M et al. ( 2013 ) . Protein Kinase C-β-Dependent Activation of NF-κB in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B Cells In Vivo . Cancer Cell vol. 23 , ( 1 ) 77 - 92 .
Finch AJ, Hilcenko C, Basse N, Drynan LF, Goyenechea B, Menne TF, Fernández AG, Simpson P et al. ( 2011 ) . Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes shwachman-diamond syndrome . Genes and Development vol. 25 , ( 9 ) 917 - 929 .
Finch AJ, Soucek L, Junttila MR, Swigart LB, Evan GI ( 2009 ) . Acute overexpression of Myc in intestinal epithelium recapitulates some but not all the changes elicited by Wnt/β-catenin pathway activation . Molecular and Cellular Biology vol. 29 , ( 19 ) 5306 - 5315 .
Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM, Karnezis AN, Swigart LB et al. ( 2008 ) . Modelling Myc inhibition as a cancer therapy . Nature vol. 455 , ( 7213 ) 679 - 683 .
Cartlidge RA, Thomas GR, Cagnol S, Jong KA, Molton SA, Finch AJ, McMahon M ( 2008 ) . Oncogenic BRAF<sup>V600E</sup> inhibits BIM expression to promote melanoma cell survival . Pigment Cell and Melanoma Research vol. 21 , ( 5 ) 534 - 544 .
Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI ( 2006 ) . The pathological response to DNA damage does not contribute to p53-mediated tumour suppression . Nature vol. 443 , ( 7108 ) 214 - 217 .
Finch A, Prescott J, Shchors K, Hunt A, Soucek L, Dansen TB, Swigart L, Evan GI ( 2006 ) . Bcl-x<inf>L</inf> gain of function and p19<sup>ARF</sup> loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms . Cancer Cell vol. 10 , ( 2 ) 113 - 120 .
Ringshausen I, O'Shea CC, Finch AJ, Swigart LB, Evan GI ( 2006 ) . Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo . Cancer Cell vol. 10 , ( 6 ) 501 - 514 .
Evan GI, Christophorou M, Lawlor EA, Ringshausen I, Prescott J, Dansen T, Finch A, Martins C et al. ( 2005 ) . Oncogene-dependent tumor suppression: Using the dark side of the force for cancer therapy . Cold Spring Harbor Symposia on Quantitative Biology . vol. 70 , 263 - 273 .
Broaddus VC, Dansen TB, Abayasiriwardana KS, Wilson SM, Finch AJ, Swigart LB, Hunt AE, Evan GI ( 2005 ) . Bid mediates apoptotic synergy between tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and DNA damage . Journal of Biological Chemistry vol. 280 , ( 13 ) 12486 - 12493 .
Finch A, Davis W, Carter WG, Saklatvala J ( 2001 ) . Analysis of mitogen-activated protein kinase pathways used by interleukin 1 in tissues in vivo: Activation of hepatic c-Jun N-terminal kinases 1 and 2, and mitogen-activated protein kinase kinases 4 and 7 . Biochemical Journal vol. 353 , ( 2 ) 275 - 281 .
Meier P, Finch A, Evan G ( 2000 ) . Apoptosis in development . Nature vol. 407 , ( 6805 ) 796 - 801 .
Lasa M, Mahtani KR, Finch A, Brewer G, Saklatvala J, Clark AR ( 2000 ) . Regulation of cyclooxygenase 2 mRNA stability by the mitogen- activated protein kinase p38 signaling cascade . Molecular and Cellular Biology vol. 20 , ( 12 ) 4265 - 4274 .
Saklatvala J, Dean J, Finch A ( 1999 ) . Protein kinase cascades in intracellular signalling by interleukin-I and tumour necrosis factor . Biochemical Society Symposium vol. 64 , 63 - 77 .
Finch A, Holland P, Cooper J, Saklatvala J, Kracht M ( 1997 ) . Selective activation of JNK/SAPK by interleukin-1 in rabbit liver is mediated by MKK7 . FEBS Letters vol. 418 , ( 1-2 ) 144 - 148 .