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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Mr Christopher Chan

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Navaratne L, Hurndall K, Richardson DM, Stephenson R, Power N, Gillott H, Sánchez SR, Khodatars K et al. ( 2021 ) . Risk factors for symptomatic anastomotic postoperative recurrence following ileo‐colic resection in Crohn’s disease . Colorectal Disease vol. 23 , ( 5 ) 1184 - 1192 .
Lynes K, Williams NS, Chan CL, Thaha MA ( 2018 ) . Reply letter to: A letter to the editor on “Anterior perineal plane for ultra-low anterior resection of the rectum (APPEAR) technique: A systematic review” . International Journal of Surgery vol. 62 ,
Greenbaum AR, Chan CLH ( 2018 ) . Skin and subcutaneous tissue . Edition ,
Chan C ( 2017 ) . The Challenges and Future Direction of the Treatment of Chronic Constipation . Diseases of the Colon & Rectum vol. 60 , ( 3 ) 253 - 255 .
McGuire C, Boundouki G, Hockley JR, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J et al. ( 2016 ) . Ex vivo study of human visceral nociceptors . GUT Article 27654583 , 1 - 11 .
Lynes K, Williams NS, Chan CL, THAHA MA ( 2016 ) . Anterior perineal plane for ultra-low anterior resection of the rectum (APPEAR) technique: A systematic review . International Journal of Surgery Article IJSU 2968 ,
Hotouras A, Ribas Y, Zakeri S, Bhan C, Wexner SD, Chan CL, Murphy J ( 2015 ) . A systematic review of the literature on the surgical management of recurrent rectal prolapse . Colorectal Disease vol. 17 , ( 8 ) 657 - 664 .
Chan CL, Hotouras A, Chaudry O ( 2015 ) . The Use of PlasmaJet as a Novel Technique for Tissue Dissection in Complex Abdominal Surgery . Diseases of the Colon & Rectum vol. 58 , ( 7 ) e402 - e403 .
Williams NS, Chan CLH ( 2015 ) . Construction of an electrically stimulated gracilis neoanalsphincter . Operative Surgery of the Colon, Rectum and Anus ,
Yongue G, Hotouras A, Murphy J, Mukhtar H, Bhan C, Chan CL ( 2015 ) . The diagnostic yield of preoperative staging computed tomography of the thorax in colorectal cancer patients without hepatic metastases . European Journal of Gastroenterology & Hepatology vol. 27 , ( 4 ) 467 - 470 .
Williams NS, Hotouras A, Bhan C, Murphy J, Chan CL ( 2015 ) . A case-controlled pilot study assessing the safety and efficacy of the Stapled Mesh stomA Reinforcement Technique (SMART) in reducing the incidence of parastomal herniation . Hernia vol. 19 , ( 6 ) 949 - 954 .
Hotouras A, Ribas Y, Zakeri S, Murphy J, Bhan C, Chan CL ( 2015 ) . Gracilis muscle interposition for rectovaginal and anovaginal fistula repair: a systematic literature review . Colorectal Disease vol. 17 , ( 2 ) 104 - 110 .
Grossi U, Hotouras A, Horrocks E, Allison M, Chan CL, Knowles CH ( 2015 ) . Home-Based Percutaneous Tibial Nerve Stimulation for Fecal Incontinence . Annals of Surgery vol. 261 , ( 1 )
Hotouras A, Bhan C, Murphy J, Chan CL, Williams NS ( 2014 ) . Parastomal Hernia Prevention . Diseases of the Colon & Rectum vol. 57 , ( 12 ) e443 - e444 .
Hotouras A, Murphy J, Allison M, Curry A, Williams NS, Knowles CH, Chan CL ( 2014 ) . Prospective clinical audit of two neuromodulatory treatments for fecal incontinence: sacral nerve stimulation (SNS) and percutaneous tibial nerve stimulation (PTNS) . Surgery Today vol. 44 , ( 11 ) 2124 - 2130 .
Ribas Y, Hotouras A, Chan CL, Clavé P ( 2014 ) . Imaging of Pelvic Floor Disorders . Diseases of the Colon & Rectum vol. 57 , ( 10 ) 1242 - 1244 .
Hockley JRF, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN et al. ( 2014 ) . Multiple roles for Na<inf>V</inf>1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli . Pain vol. 155 , ( 10 ) 1962 - 1975 .
Ribas Y, Hotouras A, Munoz-Duyos A, Murphy J, Chan CL ( 2014 ) . Sphincterotomy in Women With Chronic Anal Fissure? Are We Asking for Trouble? . Diseases of the Colon & Rectum vol. 57 , ( 9 )
Hotouras A, Ribas Y, Allison ME, Chan CL ( 2014 ) . Treatment of Fecal Incontinence in the Era of Neuromodulation . Diseases of the Colon & Rectum vol. 57 , ( 9 ) 1143 - 1144 .
Hotouras A, Murphy J, Walsh U, Allison M, Curry A, Williams NS, Knowles C, Chan CL ( 2014 ) . Outcome of Percutaneous Tibial Nerve Stimulation (PTNS) for Fecal Incontinence . Annals of Surgery vol. 259 , ( 5 ) 939 - 943 .
Hotouras A, Murphy J, Abeles A, Allison M, Williams NS, Knowles CH, Chan CL ( 2014 ) . Symptom distribution and anorectal physiology results in male patients with rectal intussusception and prolapse . Journal of Surgical Research vol. 188 , ( 1 ) 298 - 302 .
Hotouras A, Murphy J, Chan C ( 2014 ) . Response to Loganathan et al. (2013): Prolonged pudendal nerve terminal motor latency is associated with decreased resting and squeeze pressures in the intact anal sphincter . Colorectal Disease vol. 16 , ( 3 ) 219 - 219 .
Boyle DJ, Murphy J, Hotouras A, Allison ME, Williams NS, Chan CL ( 2014 ) . Electrically Stimulated Gracilis Neosphincter for End-stage Fecal Incontinence . Diseases of the Colon & Rectum vol. 57 , ( 2 ) 215 - 222 .
Hotouras A, Murphy J, Allison M, Chan CL ( 2014 ) . The Authors Reply . Diseases of the Colon & Rectum vol. 57 , ( 2 ) e18 - e19 .
Hotouras A, Haddow JB, Chan CL ( 2014 ) . Comment on Tozer et al.: Surgical management of rectovaginal fistula in a tertiary referral centre – many techniques are needed . Colorectal Disease vol. 16 , ( 2 ) 144 - 144 .
Thin NN, Horrocks EJ, Hotouras A, Palit S, Thaha MA, Chan CLH, Matzel KE, Knowles CH ( 2013 ) . Systematic review of the clinical effectiveness of neuromodulation in the treatment of faecal incontinence . British Journal of Surgery vol. 100 , ( 11 ) 1430 - 1447 .
Murphy J, Hotouras A, Koers L, Bhan C, Glynn M, Chan CL ( 2013 ) . Establishing a regional enterocutaneous fistula service: The Royal London hospital experience . International Journal of Surgery vol. 11 , ( 9 ) 952 - 956 .
Hotouras A, Murphy J, Thin NN, Allison M, Horrocks E, Williams NS, Knowles CH, Chan CL ( 2013 ) . Outcome of Sacral Nerve Stimulation for Fecal Incontinence in Patients Refractory to Percutaneous Tibial Nerve Stimulation . Diseases of the Colon & Rectum vol. 56 , ( 7 ) 915 - 920 .
Hotouras A, Allison M, Chan CLH ( 2013 ) . The Authors Reply . Diseases of the Colon & Rectum vol. 56 , ( 6 ) e329 - e330 .
Hotouras A, Murphy J, Power N, Williams NS, Chan CL ( 2013 ) . Radiological incidence of parastomal herniation in cancer patients with permanent colostomy: What is the ideal size of the surgical aperture? . International Journal of Surgery vol. 11 , ( 5 ) 425 - 427 .
Hotouras A, Murphy J, Chan C ( 2013 ) . Emergency transanal haemorrhoidal Doppler guided dearterialization for acute and persistent haemorrhoidal bleeding . Colorectal Disease vol. 15 , ( 3 ) 380 - 380 .
Hotouras A, Murphy J, THAHA MA, Chan CLH ( 2013 ) . The persistent challenge of parastomal herniation: a review of the literature and future developments . Colorectal Disease vol. 15 , ( 5 ) e202 - 2214 .
MURPHY J, Hotouras A, Boyle DJ, Allison M, Williams NS, Chan CL ( 2013 ) . Assessment of female patients with rectal intussusception and prolapse: is this a progressive spectrum of disease? . Diseases of the Colon and Rectum vol. 56 , ( 6 ) 780 - 785 .
MURPHY J, Hotouras A, Chan CL ( 2013 ) . Segmental Reversal of the Small Bowel Can End Permanent Parenteral Nutrition Dependency . Annals of Surgery vol. In Press ,
Bryant C, Lunniss PJ, Knowles CH, Thaha MA, Chan CLH ( 2012 ) . Anterior resection syndrome . Lancet Oncology vol. 13 , ( 9 ) e403 - e408 .
Murphy J, Hotouras A, Chan CL ( 2012 ) . New treatment for faecal incontinence using zinc‐aluminium ointment: a double‐blind randomized trial . Colorectal Disease vol. 14 , ( 8 ) 1029 - 1030 .
Hotouras A, Chan CL ( 2012 ) . Re: Botulinum A toxin as a treatment for overactive rectum with associated faecal incontinence . Colorectal Disease vol. 14 , ( 7 ) 898 - 899 .
Hotouras A, Allison M, Currie A, Knowles CH, Chan CLC, Thaha MA ( 2012 ) . Percutaneous Tibial Nerve Stimulation (PTNS) for faecal incontinence: a video demonstration . Diseases of the Colon and Rectum vol. 6 , ( 55 ) 711 - 713 .
Hotouras A, Thaha MA, Allison ME, Currie A, Scott M, Chan CLH ( 2012 ) . Percutaneous Tibial Nerve Stimulation (PTNS) in females with faecal incontinence: The impact of sphincter morphology and rectal sensation on the clinical outcomes . Int J Colorectal Dis. vol. 27 , ( 7 ) 927 - 930 .
Bryant CLC, Murphy J, Chan CLH ( 2012 ) . Sphincter saving resections for rectal cancer in the UK and USA - A population based study . BRITISH JOURNAL OF SURGERY . vol. 99 , 78 - 78 .
Bryant CLC, Hotouras A, Thaha MA, Chan CLH, Williams NS ( 2012 ) . The Use of Cadaveric Workshops to Disseminate Novel Surgical Technique amongst Colorectal Surgeons - The APPEAR and SMART Techniques . BRITISH JOURNAL OF SURGERY . vol. 99 , 60 - 60 .
Hotouras A, Thaha MA, Boyle D, Allison M, Currie A, Knowles CH, Chan CLH ( 2011 ) . Short-term outcomes following percutaneous tibial nerve stimulation (PTNS) for faecal incontinence: A single-centre prospective study . Colorectal Disease
Hotouras A, Bryant C, Chan CLH, Thaha MA ( 2011 ) . Use of Gentamicin impregnated collagen sheet (Collatamp) following implantation of a sacral nerve stimulator for faecal incontinence (Response) . Colorectal Disease vol. 14 , ( 4 ) 522 - 522 .
MURPHY J, Boyle DJ, Prosser K, Gooneratne M, Chan CL, Williams NS ( 2011 ) . Efficacy of Sacral Nerve Stimulation for the Treatment of Faecal Incontinence . Dis. Col. Rect. vol. 54 , ( 10 ) 1271 - 1278 .
Wijeyekoon SP, Gurusamy K, El-Gendy K, Chan CL ( 2010 ) . Prevention of Parastomal Herniation with Biologic/Composite Prosthetic Mesh: A Systematic Review and Meta-analysis of Randomized Controlled Trials . Journal of the American College of Surgeons vol. 211 , ( 5 ) 637 - 645 .
El-Gendy KA, Murphy J, Kullar NS, Chan CLH, Williams NS ( 2010 ) . Anterior Perineal PlanE for Ultralow Anterior Resection of the Rectum (the APPEAR Technique): a video demonstration . Ann Surg Oncol vol. 17 , ( 5 ) 1357 - 1358 .
Boyle DJ, Prosser K, Allison ME, Williams NS, Chan CLH ( 2010 ) . Percutaneous tibial nerve stimulation for the treatment of urge fecal incontinence . Dis Colon Rectum vol. 53 , ( 4 ) 432 - 437 .
Williams NS, Murphy J, Knowles C, Chan C, Ahmed S ( 2008 ) . Letter in response to colorectal disease article on intersphincteric resection . Colorectal Disease vol. 10 , ( 7 ) 737 - 737 .
Gooneratne ML, Facer P, Knowles C, Chan C, Frye J, Scott SM, LUNNISS P, Anand P et al. ( 2008 ) . Normalization of substance P levels in rectal mucosa of patients with faecal incontinence treated successfully by sacral nerve stimulation . Br J Surgery vol. 95 , ( 4 ) 477 - 483 .
Murphy J, Chan CLH, Scott SM, Vasudevan SP, Lunniss PJ, Williams NS ( 2008 ) . Rectal augmentation - Short- and mid- term evaluation of a novel procedure for severe fecal urgency with associated incontinence . ANN SURG vol. 247 , ( 3 ) 421 - 427 .
Greenbaum AR, Chan CLH ( 2008 ) . Skin and subcutaneous tissue . Bailey &amp; Love's Short Practice of Surgery ,
Yiangou Y, Facer P, Chessell IP, Bountra C, Chan C, Fertleman C, Smith V, Anand P ( 2007 ) . Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain) . Neuroscience Letters vol. 427 , ( 2 ) 77 - 82 .
Murphy J, Suliman I, Chan CLH ( 2007 ) . Delayed diagnosis of rhabdomyoblastoma: a cautionary tale . Colorectal Disease vol. 9 , ( 9 ) 854 - 855 .
Tan PL, Chan CLH ( 2007 ) . Bilateral pleural effusions following central venous cannulation . J POSTGRAD MED vol. 53 , ( 2 ) 117 - 118 .
Tan PH, Tan PL, George AJT, Chan CLH ( 2006 ) . Gene therapy for transplantation with viral vectors - how much of the promise has been realised? . EXPERT OPIN BIOL TH vol. 6 , ( 8 ) 759 - 772 .
Tan PH, Chan CLH, George AJT ( 2006 ) . Strategies to improve non-viral vectors - potential applications in clinical transplantation . EXPERT OPIN BIOL TH vol. 6 , ( 6 ) 619 - 630 .
Will O, Purkayastha S, Chan C, Athanasiou T, Darzi AW, Gedroyc W, Tekkis PP ( 2006 ) . Diagnostic precision of nanoparticle-enhanced MRI for lymph-node metastases: a meta-analysis . The Lancet Oncology vol. 7 , ( 1 ) 52 - 60 .
Tan PH, Chan CLH, Chan C, George AJT ( 2005 ) . The evolving role of gene-based treatment in surgery . BRIT J SURG vol. 92 , ( 12 ) 1466 - 1480 .
Chan CLH, Lunniss PJ, Wang D, Williams NS, Scott SM ( 2005 ) . Rectal sensorimotor dysfunction in patients with urge faecal incontinence: evidence from prolonged manometric studies . GUT vol. 54 , ( 9 ) 1263 - 1272 .
Tan PL, Chan CLH, Moore NR ( 2005 ) . Radiological appearances in the pelvis following rectal cancer surgery . CLIN RADIOL vol. 60 , ( 8 ) 846 - 855 .
Chan CLH, Ponsford S, Scott SM, Swash M, Lunniss PJ ( 2005 ) . Contribution of the pudendal nerve to sensation of the distal rectum . BRIT J SURG vol. 92 , ( 7 ) 859 - 865 .
Hardy A, Chan CLH, Cohen CRG ( 2005 ) . The Surgical Management of Haemorrhoids – A Review . Digestive Surgery vol. 22 , ( 1-2 ) 26 - 33 .
Chan CLH, Scott SM, Williams NS, Lunniss PJ ( 2005 ) . Rectal hypersensitivity worsens stool frequency, urgency, and lifestyle in patients with urge fecal incontinence . DIS COLON RECTUM vol. 48 , ( 1 ) 134 - 140 .
CHAN CLH, Cohen CRG, Hardy A ( 2005 ) . Review of treatments for haemorrhoids . Dig Surg vol. 22 , 26 - 33 .
Lunniss PJ, Swash M, CHAN CLH, Ponsford S ( 2005 ) . The contribution of the pudendal nerve to sensation of the distal rectum . Br J Surg vol. 92 , 859 - 865 .
CHAN CLH, Chafai N, Sinclair G, Bokey EL, Dent OF, Chapuis PH ( 2005 ) . What factors influence survival in patients with unresected synchronous liver metastases after resection of colorectal cancer? . Colorectal Dis vol. 7 , 176 - 181 .
Chan CLH, Ponsford S, Swash M ( 2004 ) . The anal reflex elicited by cough and sniff: validation of a neglected clinical sign . J NEUROL NEUROSUR PS vol. 75 , ( 10 ) 1449 - 1451 .
Lunniss PJ, WILLIAMS NS, Knowles CH, Scott SM, Dvorkin LS, Chan CLH ( 2004 ) . Anal sphincter morphology in patients with full-thickness rectal prolapse . Diseases of the Colon and Rectum. vol. 47 , ( 2 ) 198 - 203 .
CHAN CLH, Bokey EL, Chapuis PH, Dent OF, Rickard M, Chafai N ( 2004 ) . What pathological features influence survival in patients with local residual tumour after resection of colorectal carcinoma? . J Am Coll Surg vol. 199 , 680 - 686 .
Chan CLH, Scott SM, Birch MJ, Knowles CH, Williams NS, Lunniss PJ ( 2003 ) . Rectal heat thresholds - A novel test of the sensory afferent pathway . DISEASES OF THE COLON & RECTUM vol. 46 , ( 5 ) 590 - 595 .
Arnold SJ, Facer P, Yiangou Y, Chen MX, Plumpton C, Tate SN, Bountra C, Chan CLH et al. ( 2003 ) . Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel . NEUROREPORT vol. 14 , ( 2 ) 191 - 195 .
Gladman MA, Scott SM, Chan CLH, Williams NS, Lunniss PJ ( 2003 ) . Rectal hyposensitivity - Prevalence and clinical impact in patients with intractable constipation and fecal incontinence . DISEASES OF THE COLON & RECTUM vol. 46 , ( 2 ) 238 - 246 .
Chan CLH, Facer P, Davis JB, Smith GD, Egerton J, Bountra C, Williams NS, Anand P ( 2003 ) . Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency . LANCET vol. 361 , ( 9355 ) 385 - 391 .
Saunders JR, Chan CLH, Williams NS ( 2003 ) . Complications and functional outcome following artificial anal sphincter implantation (Br J Surg 2002; 89: 877‐881) . British Journal of Surgery vol. 90 , ( 2 ) 250 - 250 .
Saunders JR, Chan CLH, Williams NS ( 2003 ) . Complications and functional outcome following artificial anal sphincter implantation (Br J Surg 2002; 89: 877‐881) . British Journal of Surgery vol. 90 , ( 1 ) 121 - 121 .
Williams NS, Saunders JR, CHAN CLH ( 2003 ) . Complications and functional outcome following artificial anal sphincter implantation . Br J Surg vol. 90 ,
Chan CLH, Saunders J, Williams NS ( 2002 ) . Permanent sacral nerve stimulation for treatment of idiopathic constipation (Br J Surg 2002; 89: 882–8) . British Journal of Surgery vol. 89 , ( 11 ) 1482 - 1482 .
Chan CLH, Facer P, Davis JB, Anand P, Williams NS ( 2002 ) . Increased capsaicin receptor VR1 and related regulatory mechanisms in patients with rectal hypersensitivity and urge faecal incontinence . BRIT J SURG vol. 89 , 46 - 46 .
CHAN CLH, Burnand KG, Hay RJ, Meyer FJ ( 2001 ) . Toe ulceration associated with compression bandaging: observational study . BMJ vol. 323 , 1099 - 1099 .
Chan CLH, Yiangou Y, Facer P, Dyer NHC, Knowles CH, Williams NS, Anand P ( 2001 ) . Increased capsaicin receptor VR1-immunoreactivity in acute inflammatory bowel disease . BRIT J SURG vol. 88 , 10 - 10 .
Chan CLH, Tillin T, Scott SM, Lunniss PJ, Williams NS ( 2001 ) . Surgery for rectal urgency - quality of life and symptom analysis results for a new procedure . BRIT J SURG . vol. 88 , 52 - 52 .
Williams NS, KNOWLES CH, Chan CL, Yiangou Y, Facer P, Anand P, Dyer NH ( 2001 ) . Vanilloid receptor 1 immunoreactivity in inflamed human bowel . Lancet vol. 357 , ( 9265 ) 1338 - 1339 .
Lunniss PJ, KNOWLES CH, Scott SM, Chan CL ( 2001 ) . Exaggerated rectal adaptation - another cause of outlet obstruction . Colorectal Disease vol. 3 , ( 2 ) 141 - 142 .
Williams NS, KNOWLES CH, Chan CL, Anand P, Facer P, Baecker PA, Ford AP, Yiangou Y ( 2001 ) . ATP-gated ion channel P2X(3) is increased in human inflammatory bowel disease . Neurogastroenterol Motil vol. 13 , ( 4 ) 365 - 369 .
Chan CLH, Ray SA, Dourado R, Burnand KG ( 2000 ) . Fogarty Balloon Dilatation for Intraoperative Arterial Spasm . European Journal of Vascular and Endovascular Surgery vol. 19 , ( 6 ) 662 - 664 .
Chan C, Ray, Taylor P, Fraser S, Giddings A ( 2000 ) . Endoleaks Following Conventional Open Abdominal Aortic Aneurysm Repair . European Journal of Vascular and Endovascular Surgery vol. 19 , ( 3 ) 313 - 317 .
Quick CRG, Chan CLH, Sonoda LI, Hart AJ ( 1997 ) . Midline extraperitoneal approach for elective abdominal aortic aneurysm repair . European Journal of Vascular and Endovascular Surgery vol. 14 , ( 1 ) 63 - 68 .
Chan CLH, Villar RN ( 1996 ) . Obesity and quality of life after primary hip arthroplasty . The Bone & Joint Journal vol. 78 , ( 1 ) 78 - 81 .
John LCH, Chan CLH, Anderson DR ( 1995 ) . Potential use of the intercostal artery as an in situ graft: A cadaveric study . The Annals of Thoracic Surgery vol. 59 , ( 1 ) 190 - 195 .
Chan CLH, Norman-Taylor F, Villar RN ( 1995 ) . Septic dislocation of a total hip replacement: A forgotten complication . Journal of Orthopaedic Rheumatology vol. 8 , ( 3 ) 176 - 177 .
Chan CLH, Wigley CB, Wyse J, Berry M ( 1991 ) . Immunocytochemical analysis of glial cells in the hypomyelinated optic nerve of the BW mutant rat . Brain Cell Biology vol. 20 , ( 9 ) 732 - 745 .
Chan CLH, Wigley CB, Berry M ( 1990 ) . Oligodendrocyte-type 2 astrocyte (O-2A) progenitor cells from neonatal and adult rat optic nerve differ in their responsiveness to platelet-derived growth factor . Brain Research vol. 55 , ( 2 ) 275 - 282 .
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