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Research

Publications: Dr Tina Chowdhury

Costa E, Okesola BO, Thrasivoulou C, Becker DL, Deprest JA, David AL, Chowdhury TT ( 2021 ) . Cx43 mediates changes in myofibroblast contraction and collagen release in human amniotic membrane defects after trauma . Scientific Reports vol. 11 , ( 1 )
Meng H, Chowdhury TT, Gavara N ( 2021 ) . The Mechanical Interplay Between Differentiating Mesenchymal Stem Cells and Gelatin-Based Substrates Measured by Atomic Force Microscopy . Frontiers in Cell and Developmental Biology vol. 9 ,
Barrett DW, Okesola BO, Costa E, Thrasivoulou C, Becker DL, Mata A, Deprest JA, David AL et al. ( 2021 ) . Potential sealing and repair of human FM defects after trauma with peptide amphiphiles and Cx43 antisense . Prenatal Diagnosis vol. 41 , ( 1 ) 89 - 99 .
Derkus B, Okesola BO, BARRETT DW, D’Este M, Chowdhury TT, Eglin D, Mata A ( 2020 ) . Multicomponent hydrogels for the formation of vascularized bone-like constructs in vitro . Acta Biomaterialia
Read JE, Luo D, Chowdhury TT, Flower RJ, Poston RN, Sukhorukov GB, Gould DJ ( 2020 ) . Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production . Nanoscale vol. 12 , ( 14 ) 7735 - 7748 .
Dawsmith W, Ohtani N, Donnan R, Naftaly M, Dudley RA, Chowdhury TT ( 2020 ) . Microwave Frequency Dependent Dielectric Properties of Blood as a Potential Technique to Measure Hydration . IEEE Access1 - 1 .
BARRETT DW, John RK, Thrasivoulou C, MATA A, Deprest JA, Becker DL, David AL, CHOWDHURY TINA ( 2019 ) . Targeting mechanotransduction mechanisms and tissue weakening signals in the human amniotic membrane . Scientific Reports
Chowdhury TT, Barrett DW, David AL ( 2019 ) . Strategies to Repair Defects in the Fetal Membrane . Fetal Therapy: Scientific Basis and Critical Appraisal of Clinical Benefits ,
Engels AC, Joyeux L, Van der Merwe J, Jimenez J, Pranpanus S, Barrett DW, Connon C, Chowdhury TT et al. ( 2018 ) . Erratum to: Tissuepatch is biocompatible and seals iatrogenic membrane defects in a rabbit model (Prenatal Diagnosis, (2018), 38, 2, (99-105), 10.1002/pd.5191) . Prenatal Diagnosis vol. 38 , ( 6 )
Engels AC, Joyeux L, Van der Merwe J, Jimenez J, Prapanus S, Barrett DW, Connon C, Chowdhury TT et al. ( 2017 ) . Tissuepatch is biocompatible and seals iatrogenic membrane defects in a rabbit model . Prenatal Diagnosis vol. 38 , ( 2 ) 99 - 105 .
Barrett DW, Kethees A, Thrasivoulou C, Mata A, Virasami A, Sebire NJ, Engels AC, Deprest JA et al. ( 2017 ) . Trauma induces overexpression of Cx43 in human fetal membrane defects . Prenatal Diagnosis vol. 37 , ( 9 ) 899 - 906 .
Tilwani RK, Vessillier S, Pingguan-Murphy B, Lee DA, Bader DL, Chowdhury TT ( 2017 ) . Oxygen tension modulates the effects of TNFα in compressed chondrocytes . Inflammation Research vol. 66 , ( 1 ) 49 - 58 .
Barrett DW, David AL, Thrasivoulou C, Mata A, Becker DL, Engels AC, Deprest JA, Chowdhury TT ( 2016 ) . Connexin 43 is overexpressed in human fetal membrane defects after fetoscopic surgery . Prenatal Diagnosis vol. 36 , ( 10 ) 942 - 952 .
Engels A, Joyeux L, Connon C, Chowdhury T, David A, Deprest J ( 2016 ) . Vergleich von konventionellem Kollagen vs. modifiziertem Kollagen zum Verschluss eines iatrogenen Blasensprungs im Kaninchen-Modell . Geburtshilfe und Frauenheilkunde . vol. 76 ,
Hossain MA, Chowdhury T, Bagul A ( 2015 ) . Imaging modalities for the in vivo surveillance of mesenchymal stromal cells . Journal of Tissue Engineering and Regenerative Medicine vol. 9 , ( 11 ) 1217 - 1224 .
Peake NJ, Bader DL, Vessillier S, Ramachandran M, Salter DM, Hobbs AJ, Chowdhury TT ( 2015 ) . C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes . Biochemical and Biophysical Research Communications vol. 465 , ( 4 ) 784 - 789 .
Peake N, Pavlov A, D'Souza A, Alfasahin I, Pingaan-Murphy B, Sukhurukov G, Hobbs A, Chowdhury T ( 2015 ) . Polyelectrolyte microencapsules loaded with C-type natriuretic peptide protect cartilage from IL-1B induced damage . Osteoarthritis and Cartilage vol. 23 , a141 - a142 .
Peake NJ, Pavlov AM, D'Souza A, Pingguan-Murphy B, Sukhorukov GB, Hobbs AJ, CHOWDHURY TT ( 2015 ) . Controlled Release of C-Type Natriuretic Peptide by Microencapsulation Dampens Proinflammatory Effects Induced by IL-1β in Cartilage Explants . Biomacromolecules
Peake NJ, Hobbs AJ, Pingguan-Murphy B, Salter DM, Berenbaum F, Chowdhury TT ( 2014 ) . Role of C-type natriuretic peptide signalling in maintaining cartilage and bone function . Osteoarthritis and Cartilage vol. 22 , ( 11 ) 1800 - 1807 .
Peake NJ, Hobbs AJ, Pingguan-Murphy B, Salter DM, Berenbaum F, CHOWDHURY TT ( 2014 ) . Role of C-type natriuretic peptide signaling in maintaining cartilage and bone function . Osteoarthritis and Cartilage vol. online edition ,
Hossain MA, CHOWDHURY TT, Bagul A ( 2014 ) . Imaging modalities for the in vivo surveillance of mesenchymal stromal cells . Journal of Tissue Engineering and Regenerative Medicine
Chowdhury B, David A, Bader D, Thrasivoulou C, Becker D, Chowdhury T ( 2014 ) . PFM.37 Cyclic tensile strain increases PGE2 release leading to weakening of the human term amniotic membrane . Archives of Disease in Childhood - Fetal and Neonatal Edition vol. 99 , ( Suppl 1 )
Parker E, Vessillier S, Abas WW, Bader DL, Pinguaan-Murphy B, Chowdhury TT ( 2014 ) . α5β1 integrin mediates compression-induced inhibition of catabolic effects induced by fibronectin fragments in an oxygen-dependent manner . Osteoarthritis and Cartilage vol. 22 ,
Chowdhury B, David AL, Thrasivoulou C, Becker DL, Bader DL, Chowdhury TT ( 2014 ) . Tensile strain increased COX-2 expression and PGE<inf>2</inf> release leading to weakening of the human amniotic membrane . Placenta vol. 35 , ( 12 ) 1057 - 1064 .
Parker E, Vessillier S, Pinguaan-Murphy B, Wan Abas WAB, Bader DL, Chowdhury TT ( 2013 ) . Low oxygen tension increased FN-f induced catabolic activities - response prevented with biomechanical signals . Arthritis Research and Therapy vol. 15 , ( 5 ) R163 - R163 .
Peake N, Su N, Ramachandran M, Achan P, Salter DM, Bader DL, Moyes AJ, Hobbs AJ et al. ( 2013 ) . Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model . Arthritis Research and Therapy vol. 15 , ( 4 )
Akanji O, Salter DM, Chowdhury TT ( 2013 ) . Optimisation of quantitative real-time PCR studies in cartilage mechanobiology . PCR Technology. Current innovations , Editors: Nolan, T, Bustin, SA , CRC PressI Llc
Parker E, Pinguuan-Murphy B, Bader DL, Chowdhury TT ( 2013 ) . FN-f induced catabolic activities are dependent on oxygen tension in chondrocyte/agarose constructs subjected to biomechanical signals . Osteoarthritis and Cartilage vol. 21 ,
Hossain MA, Frampton AE, Chowdhury TT, Morsey M ( 2013 ) . Biological vascular grafts for hemodialysis access . Expert Rev Med Devices vol. 2 , ( 10 ) 171 - 175 .
Peake N, Ramachandran M, Achan P, Salter DM, Bader DL, Chowdhury TT ( 2012 ) . MECHANICAL SIGNALS MODULATE THE C-TYPE NATRIURETIC PEPTIDE RECEPTORS VIA CGMP AND PKG DEPENDENT PATHWAYS . OSTEOARTHRITIS AND CARTILAGE . vol. 20 , S243 - S243 .
CHOWDHURY TT, Tilwani RK, Bader DL ( 2012 ) . Biomechanical conditioning enhanced matrix synthesis in nucleus pulposus cells cultured in agarase constructs with TGFβ . Journal Functional Biomaterials vol. 3 , 23 - 26 .
Ramachandran M, Achan P, Salter DM, Bader DL, Chowdhury TT ( 2011 ) . Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyte/agarose constructs . Arthritis Research and Therapy vol. 13 , ( 5 )
Bader DL, Salter DM, Chowdhury TT ( 2011 ) . Biomechanical influence of cartilage homeostasis in health and disease . Arthritis vol. 2011 ,
Lee DA, Brand J, Salter D, Akanji OO, Chowdhury TT ( 2011 ) . Quantification of mRNA Using Real-Time PCR and Western Blot Analysis of MAPK Events in Chondrocyte/Agarose Constructs . vol. 695 , 77 - 97 .
Chowdhury TT, Schulz RM, Rai SS, Thuemmler C, Wuestneck N, Bader A, Homandberg GA ( 2010 ) . BIOMECHANICAL MODULATION OF COLLAGEN FRAGMENT INDUCED ANABOLIC AND CATABOLIC ACTIVITIES IN CHONDROCYTE/AGAROSE CONSTRUCTS . OSTEOARTHRITIS AND CARTILAGE . vol. 18 , S216 - S216 .
Chowdhury TT, Schulz RM, Rai SS, Thuemmler CB, Wuestneck N, Bader A, Homandberg GA ( 2010 ) . Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs . Arthritis Research and Therapy vol. 12 , ( 3 )
Akanji OO, Sakthithasan P, Salter DM, Chowdhury TT ( 2010 ) . Dynamic compression alters NFκB activation and IκB-α expression in IL-1β-stimulated chondrocyte/agarose constructs . Inflammation Research vol. 59 , ( 1 ) 41 - 52 .
McGlashan SR, Knight MM, Chowdhury TT, Joshi P, Jensen CG, Kennedy S, Poole CA ( 2010 ) . Mechanical loading modulates chondrocyte primary cilia incidence and length . Cell Biology International vol. 34 , ( 5 ) 441 - 446 .
Shala K, Yang B, Dudley R, Chowdhury TT, Donnan RS ( 2009 ) . Quantification of glucose and cytosine hydrochloride by THz-TDS . Loughborough Antennas and Propagation Conference, LAPC 2009 - Conference Proceedings . 501 - 503 .
Akanji OO, Salter DM, Chowdhury TT ( 2009 ) . 458 DYNAMIC COMPRESSION ALTERS NF?B ACTIVATION AND I?B-α EXPRESSION IN IL-1β STIMULATED CHONDROCYTE/AGAROSE CONSTRUCTS . Osteoarthritis and Cartilage vol. 17 , s245 - s246 .
Raveenthiran SP, Chowdhury TT ( 2009 ) . Dynamic compression inhibits fibronectin fragment induced iNOS and COX-2 expression in chondrocyte/agarose constructs . Biomechanics and Modeling in Mechanobiology vol. 8 , ( 4 ) 273 - 283 .
Chowdhury TT, Akanji OO, Salter DM, Bader DL, Lee DA ( 2008 ) . Dynamic compression influences interleukin-1β-induced nitric oxide and prostaglandin E<inf>2</inf> release by articular chondrocytes via alterations in iNOS and COX-2 expression . Biorheology vol. 45 , ( 3-4 ) 257 - 274 .
Raveenthiran SP, Chowdhury TT ( 2008 ) . 451 DYNAMIC COMPRESSION COUNTERACTS FIBRONECTIN-FRAGMENT INDUCED INOS AND COX-2 EXPRESSION IN CHONDROCYTE/AGAROSE CONSTRUCTS . Osteoarthritis and Cartilage vol. 16 , s195 - s196 .
Chowdhury TT, Salter DM, Bader DL, Lee DA ( 2008 ) . Signal transduction pathways involving p38 MAPK, JNK, NFκB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1β and dynamic compression . Inflammation Research vol. 57 , ( 7 ) 306 - 313 .
Chowdhury TT, Arghandawi S, Brand J, Akanji OO, Bader DL, Salter DM, Lee DA ( 2008 ) . Dynamic compression counteracts IL-1β induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs . Arthritis Research and Therapy vol. 10 , ( 2 )
CHOWDHURY TT, Akanjii OO, Salter DM, Lee DA ( 2008 ) . Dynamic compression influences IL-1β induced NO and PGE2 release, via alterations in iNOS and COX-2 activity . 5th International Symposium on Mechanobiology of Cartilage and Chondrocyte , Editors: Stoltz, JF , vol. 5 ,
Chowdhury TT, Akanji OO, Arghandawi S, Salter DM, Bader DL, Lee DA ( 2007 ) . 52 REAL-TIME PCR USING MOLECULAR BEACONS TO DETECT INOS AND COX-2 EXPRESSION IN CHONDROCYTE/AGAROSE CONSTRUCTS SUBJECTED TO IL-1β AND DYNAMIC COMPRESSION . Osteoarthritis and Cartilage vol. 15 , c42 - c43 .
Campbell JJ, Blain EJ, Chowdhury TT, Knight MM ( 2007 ) . Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes . Biochemical and Biophysical Research Communications vol. 361 , ( 2 ) 329 - 334 .
Chowdhury TT, Akanji OO, Arghandawi, Salter DM, Bader DL, Lee DA ( 2007 ) . Dynamic compression counteracts IL-1 beta b induced iNOS and COX-2 expression in chondrocytes cultured in agarose constructs . TISSUE ENGINEERING . vol. 13 , 1677 - 1677 .
Chowdhury TT, Knight MM ( 2006 ) . Purinergic pathway suppresses the release of NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression . Journal of Cellular Physiology vol. 209 , ( 3 ) 845 - 853 .
Chowdhury TT, Bader DL, Lee DA ( 2006 ) . Dynamic compression counteracts IL-1β induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs . Biorheology vol. 43 , ( 3-4 ) 413 - 429 .
Chowdhury TT, Appleby RN, Salter DM, Bader DA, Lee DA ( 2006 ) . Integrin-mediated mechanotransduction in IL-1β stimulated chondrocytes . Biomechanics and Modeling in Mechanobiology vol. 5 , ( 2-3 ) 192 - 201 .
Chowdhury TT, Bader DL, Lee DA ( 2006 ) . Anti-inflammatory effects of IL-4 and dynamic compression in IL-1β stimulated chondrocytes . Biochemical and Biophysical Research Communications vol. 339 , ( 1 ) 241 - 247 .
CHOWDHURY TT, Bader DL, Lee DA ( 2006 ) . Dynamic compression counteracts IL-1β induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs . Mechanobiology: Cartilage and Chondrocyte , Editors: Stoltz, JF , vol. 3 , IOS Press
McGlashan SR, Chowdhury TT, Joshi P, Knight MM, Poole CA, Jensen CG ( 2006 ) . Mechanical Compression Reduces Chondrocyte Primary Cilia Expression In Vitro . MOL BIOL CELL . vol. 17 ,
Chowdhury TT, Raveenthiran SP, Bader DL, Lee DA ( 2006 ) . P140 DYNAMIC COMPRESSION COUNTERACTS FIBRONECTIN FRAGMENT INDUCED UPREGULATION OF NITRIC OXIDE . Osteoarthritis and Cartilage vol. 14 ,
Chowdhury TT, Bader DL, Lee DA ( 2005 ) . Dynamic compression counteracts IL-1-induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs . Proceedings of the 2005 Summer Bioengineering Conference vol. 2005 , 251 - 252 .
Chowdhury TT, Appleby RN, Salter DA, Bader DL, Lee DA ( 2005 ) . Integrin mediated mechanotransduction in IL-1 stimulated bovine chondrocytes cultured in agarose constructs . Proceedings of the 2005 Summer Bioengineering Conference vol. 2005 , 545 - 546 .
Chowdhury TT, Bader DL, Lee DA ( 2005 ) . Dynamic compression counteracts IL-1β induced INOS and COX-2 activity by human chondrocytes cultured in agarose constructs . European Cells and Materials vol. 10 , ( SUPPL.2 )
Catuogno C, Chowdhury TT, Bader DL, Lee DA ( 2005 ) . Dynamic compression influences the biochemical response of human mesenchymal stem cells cultured in agarose constructs . European Cells and Materials vol. 10 , ( SUPPL.2 )
Sudre L, Cheung F, Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S et al. ( 2005 ) . British society for matrix biology autumn meeting . International Journal of Experimental Pathology vol. 86 , ( 3 )
Chowdhury TT, Bader DL, Lee AA ( 2005 ) . Dynamic compression counteracts IL-1 beta-induced iNOS and COX-2 activity in human chondrocytes cultured in agarose constructs . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 86 , A33 - A34 .
Appleby RN, Chowdhury TT, Salter DM, Bader DL, Lee DA ( 2005 ) . Integrin-mediated mechanotransduction in IL-1 beta-stimulated chondrocytes . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 86 , A38 - A39 .
Chowdhury TT, Salter DM, Bader DL, Lee DA ( 2004 ) . Integrin-mediated mechanotransduction processes in TGFβ-stimulated monolayer-expanded chondrocytes . Biochemical and Biophysical Research Communications vol. 318 , ( 4 ) 873 - 881 .
Bryant SJ, Chowdhury TT, Lee DA, Bader DL, Anseth KS ( 2004 ) . Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels . Annals of Biomedical Engineering vol. 32 , ( 3 ) 407 - 417 .
Chowdhury TT, Bader DL, LEE DA ( 2004 ) . Combined anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated bovine chondrocytes cultured in agarose constructs . Trans. Orthop. Res. Soc. . Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29 , 144 - 144 .
Chowdhury TT, Bader DL, Lee DA ( 2004 ) . Dynamic compression counteracts IL-1 beta-induced iNOS and COX-2 activity in human chondrocytes cultured in agarose constructs . OSTEOARTHRITIS AND CARTILAGE . vol. 12 , S19 - S19 .
Chowdhury TT, Appleby RN, Salter DM, Bader DL, Lee DA ( 2004 ) . Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes . OSTEOARTHRITIS AND CARTILAGE . vol. 12 , S102 - S102 .
Chowdhry TT, Salter DM, Bader DL, LEE DA ( 2004 ) . alpha 5 beta 1 integrin mediates mechanotransduction processes in TGF-beta stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression . Trans. Orthop. Res. Soc. . Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29 , 338 - 338 .
Chowdhury TT, Bader DL, Lee DA ( 2003 ) . Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs . Osteoarthritis Cartilage vol. 11 , ( 9 ) 688 - 696 .
Chowdhury TT, Bader DL, Shelton JC, Lee DA ( 2003 ) . Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression . Archives of Biochemistry and Biophysics vol. 417 , ( 1 ) 105 - 111 .
Chowdhury TT, Shelton JC, Bader DL, LEE DA ( 2003 ) . Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs . Internat. J. Artificial Organs vol. 26 , ( 9 ) 858 - 858 .
Chowdhury TT, LEE DA, Salter DM, Shelton JC, Bader DL ( 2003 ) . alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression . Osteoarthritis Cartilage vol. 11 , ( Suppl 1 ) S2 - S3 .
Chowdhury TT, LEE DA, Salter DM, Shelton JC, Bader DL ( 2003 ) . alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta3-stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression . Tissue Engineering . Conference: ETES vol. 9 , 792 - 792 .
Lee DA, Chowdhury TT, Roberts SR, Knight MM, Bader DL ( 2002 ) . An in vitro investigation of cartilage mechanotransduction . INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS . vol. 25 , 617 - 618 .
Chowdhury TT, Bader DL, Lee DA ( 2001 ) . Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs . Biochem Biophys Res Commun vol. 285 , ( 5 ) 1168 - 1174 .
Chowdhury T, Bader DL, LEE DA ( 2001 ) . Dynamic compression influences the synthesis of nitric oxide by IL-1beta stimulated chondrocyte sub-populations cultured in agarose constructs . Trans. Orthop. Res. Soc . Conference: 47th Annual Meeting, Orthopaedic Research Society ( San Francisco, California ) from: 25/02/2001 to: 28/02/2001 , vol. 26 , 604 - 604 .
Chowdhury TT, Bader DL, Lee DA ( 2000 ) . Dynamic compression inhibits the synthesis of nitric oxide by IL-1β stimulated chondrocytes cultured in agarose constructs . Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling