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Research

Publications: Dr Hannah Heywood

Heywood HK, Gardner L, Knight MM, Lee DA ( 2022 ) . Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems . In vitro models1 - 8 .
Thompson CL, Fu S, Heywood HK, Knight MM, Thorpe SD ( 2021 ) . Corrigendum: Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models (Front. Bioeng. Biotechnol., (2020), 8, 602646, 10.3389/fbioe.2020.602646) . Frontiers in Bioengineering and Biotechnology vol. 9 ,
Thompson CL, Fu S, Knight MM, Thorpe SD ( 2020 ) . Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models . Frontiers in Bioengineering and Biotechnology vol. 8 ,
Heywood HK, Thorpe SD, Jeropoulos RM, Lee DA ( 2017 ) . Small molecule activators of SIRT1 augment the regenerative potential of chondrocytes for cell-based cartilage repair techniques . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 98 , A14 - A14 .
Heywood HK, Caton PW, Lee DA ( 2016 ) . SIRT1, an enzyme vital to cartilage homeostasis, is regulated by osmolarity and glucose levels . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 97 , A2 - A2 .
Heywood HK, Lee DA ( 2016 ) . Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygen . Journal of Tissue Engineering and Regenerative Medicine vol. 11 , ( 8 ) 2286 - 2294 .
Heywood HK, Lee DA ( 2014 ) . Reactive oxygen species drive the transformation to an oxidative energy metabolism in cultured articular chondrocytes . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 95 , A15 - A16 .
Heywood HK, Nalesso G, Lee DA, Dell'accio F ( 2014 ) . Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture . Biores Open Access vol. 3 , ( 1 ) 9 - 18 .
Pattappa G, Thorpe SD, Jegard NC, Heywood HK, de Bruijn JD, Lee DA ( 2013 ) . Continuous and uninterrupted oxygen tension influences the colony formation and oxidative metabolism of human mesenchymal stem cells . Tissue Eng Part C Methods vol. 19 , ( 1 ) 68 - 79 .
Gammon L, Biddle A, Heywood HK, Johannessen AC, Mackenzie IC ( 2013 ) . Sub-sets of cancer stem cells differ intrinsically in their patterns of oxygen metabolism . PLoS One vol. 8 , ( 4 )
Pattappa G, Heywood HK, de Bruijn JD, Lee DA ( 2011 ) . The metabolism of human mesenchymal stem cells during proliferation and differentiation . J Cell Physiol vol. 226 , ( 10 ) 2562 - 2570 .
Martyn SV, Heywood HK, Rockett P, Paine MD, Wang MJ, Dobson PJ, Sheard SJ, Lee DA et al. ( 2011 ) . Electrospray deposited fibronectin retains the ability to promote cell adhesion . J BIOMED MATER RES B vol. 96B , ( 1 ) 110 - 118 .
Pattappa G, Heywood HK, de Bruijn JD, Lee DA ( 2010 ) . The metabolism of human mesenchymal stem cells during proliferation and differentiation . J Cell Physiol
Heywood HK, Knight MM, Lee DA ( 2010 ) . Both superficial and deep zone articular chondrocyte subpopulations exhibit the Crabtree effect but have different basal oxygen consumption rates . J Cell Physiol vol. 223 , ( 3 ) 630 - 639 .
Heywood HK, Lee DA ( 2010 ) . Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes . J Cell Physiol vol. 222 , ( 1 ) 248 - 253 .
Heywood HK, Lee DA ( 2008 ) . Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes . Biochem Biophys Res Commun vol. 373 , ( 2 ) 224 - 229 .
Heywood HK, Lee DA ( 2008 ) . The effect of oxygen supply on chondrocyte metabolic phenotype during monolayer culture . European Cells and Materials vol. 16 , ( SUPPL. 3 )
Heywood HK, Lee DA ( 2007 ) . Development of an immunoassay for determination of adsorbed fibronectin levels on bio-functionalised substrates . TISSUE ENGINEERING . vol. 13 , 1669 - 1670 .
Heywood HK, Bader DL, Lee DA ( 2006 ) . Glucose concentration and medium volume influence cell viability and glycosaminoglycan synthesis in chondrocyte-seeded alginate constructs . Tissue Eng . vol. 12 , 3487 - 3496 .
Heywood HK, Bader DL, Lee DA ( 2006 ) . Glucose Concentration and Medium Volume Influences Cell Viability and Glycosaminoglycan Synthesis in Chondrocyte-Seeded Alginate Constructs . Tissue Engineering vol. 0 , ( 0 )
Heywood HK, Bader DL, Lee DA ( 2006 ) . Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration . J Cell Physiol vol. 206 , ( 2 ) 402 - 410 .
Wang MJ, Heywood HK, Bader DL, Paine MD, Stark JPW, Lee DA ( 2005 ) . Identification and characterization of deposited fibronectin on biocompatible materials: Comparison of electrospray and wetting methods . Proceedings of the 2005 Summer Bioengineering Conference vol. 2005 , 439 - 440 .
Sengers BG, Heywood HK, Lee DA, Oomens CWJ, Bader DL ( 2005 ) . Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach . J Biomech Eng vol. 127 , ( 5 ) 758 - 766 .
Heywood HK, Bader DL, Lee DA ( 2005 ) . Superficial and deep chondrocyte subpopulations both express the crabtree effect but exhibit differences in oxygen consumption rate . European Cells and Materials vol. 10 , ( SUPPL.2 )
Sudre L, Cheung F, Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S et al. ( 2005 ) . British society for matrix biology autumn meeting . International Journal of Experimental Pathology vol. 86 , ( 3 )
Heywood HK, Bader DL, Lee DA ( 2005 ) . Glucose metabolism of chondrocytes in tissue-engineered alginate constructs . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 86 , A13 - A14 .
Heywood HK, Sembi PK, Lee DA, Bader DL ( 2004 ) . Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs . Tissue Eng vol. 10 , ( 9-10 ) 1467 - 1479 .
Heywood HK, Bader DL, Bongers M, LEE DA ( 2004 ) . Glucose depletion induces an upregulation of oxygen utilisation by chondrocytes . Trans. Orthop. Res. Soc. . Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29 , 261 - 261 .
Heywood HK, DeRosa E, LEE DA, Bader DL, Netti P ( 2004 ) . Non-invasive monitoring of molecular diffusion in neo-cartilage using FRAP technique . Trans. Orthop. Res. Soc. . Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29 , 531 - 531 .
LEE DA, Heywood HK, Baaijens FPT, Oomens CWJ, Sengers BG ( 2003 ) . Experimental and theoretical analysis of glucose dependent oxygen utilization by bovine articular chondrocytes . Internat. J. Artificial Organs vol. 26 , 875 - 875 .
Heywood HK, LEE DA, Bader DL ( 2002 ) . Monitoring neo-cartilage formation in cell seeded alginate constructs of clinically relevant dimensions . Eur. Cells Materials . Conference: TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society ( Glasgow, Scotland ) from: 19/09/2002 to: 20/09/2002 , vol. 4 suppl 2 , 1 - 2 .