Publications: Dr Hannah Heywood
Heywood HK, Thorpe SD, Jeropoulos RM, Caton PW, Lee DA
(
2023
)
.
Modulation of sirtuins during monolayer chondrocyte culture influences cartilage regeneration upon transfer to a 3D culture environment
.
Frontiers in Bioengineering and Biotechnology
vol.
10
,
Heywood HK, Gardner L, Knight MM, Lee DA
(
2022
)
.
Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems
.
In vitro models1
-
8
.
Thompson CL, Fu S, Heywood HK, Knight MM, Thorpe SD
(
2021
)
.
Corrigendum: Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models (Front. Bioeng. Biotechnol., (2020), 8, 602646, 10.3389/fbioe.2020.602646)
.
Frontiers in Bioengineering and Biotechnology
vol.
9
,
Thompson CL, Fu S, Knight MM, Thorpe SD
(
2020
)
.
Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models
.
Frontiers in Bioengineering and Biotechnology
vol.
8
,
Heywood HK, Thorpe SD, Jeropoulos RM, Lee DA
(
2017
)
.
Small molecule activators of SIRT1 augment the regenerative potential of chondrocytes for cell-based cartilage repair techniques
.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
.
vol.
98
,
A14
-
A14
.
Heywood HK, Lee DA
(
2016
)
.
Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygen
.
Journal of Tissue Engineering and Regenerative Medicine
vol.
11
,
(
8
)
2286
-
2294
.
Heywood HK, Caton PW, Lee DA
(
2016
)
.
SIRT1, an enzyme vital to cartilage homeostasis, is regulated by osmolarity and glucose levels
.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
.
vol.
97
,
A2
-
A2
.
Heywood HK, Nalesso G, Lee DA, Dell'accio F
(
2014
)
.
Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture
.
Biores Open Access
vol.
3
,
(
1
)
9
-
18
.
Heywood HK, Lee DA
(
2014
)
.
Reactive oxygen species drive the transformation to an oxidative energy metabolism in cultured articular chondrocytes
.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
.
vol.
95
,
A15
-
A16
.
Pattappa G, Thorpe SD, Jegard NC, Heywood HK, de Bruijn JD, Lee DA
(
2013
)
.
Continuous and uninterrupted oxygen tension influences the colony formation and oxidative metabolism of human mesenchymal stem cells
.
Tissue Eng Part C Methods
vol.
19
,
(
1
)
68
-
79
.
Gammon L, Biddle A, Heywood HK, Johannessen AC, Mackenzie IC
(
2013
)
.
Sub-sets of cancer stem cells differ intrinsically in their patterns of oxygen metabolism
.
PLoS One
vol.
8
,
(
4
)
Pattappa G, Heywood HK, de Bruijn JD, Lee DA
(
2011
)
.
The metabolism of human mesenchymal stem cells during proliferation and differentiation
.
J Cell Physiol
vol.
226
,
(
10
)
2562
-
2570
.
Martyn SV, Heywood HK, Rockett P, Paine MD, Wang MJ, Dobson PJ, Sheard SJ, Lee DA et al.
(
2011
)
.
Electrospray deposited fibronectin retains the ability to promote cell adhesion
.
J BIOMED MATER RES B
vol.
96B
,
(
1
)
110
-
118
.
Pattappa G, Heywood HK, de Bruijn JD, Lee DA
(
2010
)
.
The metabolism of human mesenchymal stem cells during proliferation and differentiation
.
J Cell Physiol
Heywood HK, Knight MM, Lee DA
(
2010
)
.
Both superficial and deep zone articular chondrocyte subpopulations exhibit the Crabtree effect but have different basal oxygen consumption rates
.
J Cell Physiol
vol.
223
,
(
3
)
630
-
639
.
Heywood HK, Lee DA
(
2010
)
.
Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes
.
J Cell Physiol
vol.
222
,
(
1
)
248
-
253
.
Heywood HK, Lee DA
(
2008
)
.
Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes
.
Biochem Biophys Res Commun
vol.
373
,
(
2
)
224
-
229
.
Heywood HK, Lee DA
(
2008
)
.
The effect of oxygen supply on chondrocyte metabolic phenotype during monolayer culture
.
European Cells and Materials
vol.
16
,
(
SUPPL. 3
)
Heywood HK, Lee DA
(
2007
)
.
Development of an immunoassay for determination of adsorbed fibronectin levels on bio-functionalised substrates
.
TISSUE ENGINEERING
.
vol.
13
,
1669
-
1670
.
Heywood HK, Bader DL, Lee DA
(
2006
)
.
Glucose concentration and medium volume influence cell viability and glycosaminoglycan synthesis in chondrocyte-seeded alginate constructs
.
Tissue Eng
.
vol.
12
,
3487
-
3496
.
Heywood HK, Bader DL, Lee DA
(
2006
)
.
Glucose Concentration and Medium Volume Influences Cell Viability and Glycosaminoglycan Synthesis in Chondrocyte-Seeded Alginate Constructs
.
Tissue Engineering
vol.
0
,
(
0
)
Heywood HK, Bader DL, Lee DA
(
2006
)
.
Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration
.
J Cell Physiol
vol.
206
,
(
2
)
402
-
410
.
Wang MJ, Heywood HK, Bader DL, Paine MD, Stark JPW, Lee DA
(
2005
)
.
Identification and characterization of deposited fibronectin on biocompatible materials: Comparison of electrospray and wetting methods
.
Proceedings of the 2005 Summer Bioengineering Conference
vol.
2005
,
439
-
440
.
Sengers BG, Heywood HK, Lee DA, Oomens CWJ, Bader DL
(
2005
)
.
Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach
.
J Biomech Eng
vol.
127
,
(
5
)
758
-
766
.
Heywood HK, Bader DL, Lee DA
(
2005
)
.
Superficial and deep chondrocyte subpopulations both express the crabtree effect but exhibit differences in oxygen consumption rate
.
European Cells and Materials
vol.
10
,
(
SUPPL.2
)
Sudre L, Cheung F, Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S et al.
(
2005
)
.
British society for matrix biology autumn meeting
.
International Journal of Experimental Pathology
vol.
86
,
(
3
)
Heywood HK, Bader DL, Lee DA
(
2005
)
.
Glucose metabolism of chondrocytes in tissue-engineered alginate constructs
.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
.
vol.
86
,
A13
-
A14
.
Heywood HK, Sembi PK, Lee DA, Bader DL
(
2004
)
.
Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs
.
Tissue Eng
vol.
10
,
(
9-10
)
1467
-
1479
.
Heywood HK, Bader DL, Bongers M, LEE DA
(
2004
)
.
Glucose depletion induces an upregulation of oxygen utilisation by chondrocytes
.
Trans. Orthop. Res. Soc.
.
Conference:
50th Annual Meeting of the Orthopaedic Research Society
vol.
29
,
261
-
261
.
Heywood HK, DeRosa E, LEE DA, Bader DL, Netti P
(
2004
)
.
Non-invasive monitoring of molecular diffusion in neo-cartilage using FRAP technique
.
Trans. Orthop. Res. Soc.
.
Conference:
50th Annual Meeting of the Orthopaedic Research Society
vol.
29
,
531
-
531
.
LEE DA, Heywood HK, Baaijens FPT, Oomens CWJ, Sengers BG
(
2003
)
.
Experimental and theoretical analysis of glucose dependent oxygen utilization by bovine articular chondrocytes
.
Internat. J. Artificial Organs
vol.
26
,
875
-
875
.
Heywood HK, LEE DA, Bader DL
(
2002
)
.
Monitoring neo-cartilage formation in cell seeded alginate constructs of clinically relevant dimensions
.
Eur. Cells Materials
.
Conference:
TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society
(
Glasgow, Scotland
)
from:
19/09/2002
to:
20/09/2002
,
vol.
4 suppl 2
,
1
-
2
.