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Research

Publications: Prof Daniel Pennington

Anene CA, Taggart E, Harwood CA, Pennington DJ, Wang J ( 2022 ) . Decosus: An R Framework for Universal Integration of Cell Proportion Estimation Methods . Frontiers in Genetics vol. 13 ,
Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Zaman N, Tsisanova E, Mastroianni G et al. ( 2021 ) . Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy . Cell and Tissue Research vol. 386 , ( 1 ) 79 - 98 .
Sumaria N, Martin S, Pennington DJ ( 2021 ) . PI3K inhibition reveals a novel gamma delta T cell-associated transcriptional program during thymic development . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 51 , 176 - 176 .
Pennington D, Sumaria N, Martin S ( 2021 ) . Constrained TCRγδ-associated Syk activity engages PI3K to facilitate thymic development of IL-17A–secreting γδ T cells . Science Signaling
Park JE, JebaMercy G, Pazhanchamy K, Guo X, Ngan SFC, Liou KCK, Lynn SES, Ng SS et al. ( 2021 ) . Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis . Atherosclerosis vol. 324 , 58 - 68 .
Chao-Chu J, Murtough S, Zaman N, Pennington DJ, Blaydon DC, Kelsell DP ( 2021 ) . iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility . Journal of Investigative Dermatology vol. 141 , ( 4 ) 722 - 726 .
Pennington D, Lynch L, Silva-Santos B, Lopes N, McIntyre C, Martin S, Sumaria N, Raverdeau M ( 2021 ) . Distinct metabolic programmes established in the thymus control effector functions of gd T cell subsets in tumour microenvironments . Nature Immunology179 - 192 .
Galson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK et al. ( 2020 ) . Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures . Frontiers in Immunology vol. 11 ,
Clohosey ML, Mann BT, Ryan PL, Apanasovich TV, Maggirwar SB, Pennington DJ, Soriano-Sarabia N ( 2020 ) . Comparable Vδ2 Cell Functional Characteristics in Virally Suppressed People Living with HIV and Uninfected Individuals . Cells vol. 9 , ( 12 )
Galson J, Schaetzle S, Bashford-Rogers R, Raybould M, Kovaltsuk A, Kilpatrick G, Minter R, Finch D et al. ( 2020 ) . Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures .
Murtough S, Webb CM, Chikh A, Picard HLD, Pink R, Wang J, Fitzgerald R, Risk J et al. ( 2019 ) . 423 Type 2 Immunity Linked to iRhom2 and Tylosis with Oesophageal Cancer . Journal of Investigative Dermatology . vol. 139 ,
Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al. ( 2019 ) . 454 iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus . Journal of Investigative Dermatology vol. 139 , ( 5 )
Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al. ( 2019 ) . iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 139 , S78 - S78 .
Sumaria N, Martin S, Pennington DJ ( 2019 ) . Developmental origins of murine γδ T-cell subsets . Immunology vol. 156 , ( 4 ) 299 - 304 .
Edelblum K, Gustafsson K, Pennington DJ, Willcox BE, Ribot JC ( 2019 ) . Bordeaux 2018: Wine, cheese, and γδ t cells . Frontiers in Immunology vol. 10 , ( OCT )
Grandjean CL, Sumaria N, Martin S, Pennington DJ ( 2017 ) . Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ<sup>(+)</sup>CD8αα<sup>(+)</sup> intraepithelial lymphocytes . Scientific Reports vol. 7 , ( 1 )
CABRERA CP, MANSON J, SHEPHERD JM, TORRANCE HD, WATSON D, LONGHI MP, HOTI M, PATEL MB et al. ( 2017 ) . Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma . PLoS Medicine
Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al. ( 2017 ) . Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study . PLoS Medicine vol. 14 , ( 7 )
Sumaria N, Grandjean CL, Silva-Santos B, Pennington DJ ( 2017 ) . Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells . Cell Rep vol. 19 , ( 12 ) 2469 - 2476 .
Muñoz-Ruiz M, Sumaria N, Pennington DJ, Silva-Santos B ( 2017 ) . Thymic Determinants of γδ T Cell Differentiation . Trends in Immunology vol. 38 , ( 5 ) 336 - 344 .
Fechter K, Dorronsoro A, Jakobsson E, Ferrin I, Lang V, Sepulveda P, Pennington DJ, Trigueros C ( 2017 ) . IFNγ Regulates Activated Vδ2+ T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells . PLoS One vol. 12 , ( 1 ) e0169362 - e0169362 .
Ryan PL, Sumaria N, Holland CJ, Bradford CM, Izotova N, Grandjean CL, Jawad AS, Bergmeier LA et al. ( 2016 ) . Heterogeneous yet stable Vδ2(+) T cell profiles define distinct cytotoxic effector potentials in healthy human individuals . Proceedings of the National Academy of Sciences vol. 113 , ( 50 ) 14378 - 14383 .
Manson J, Cole E, De’Ath HD, Vulliamy P, Meier U, Pennington D, Brohi K ( 2016 ) . Early changes within the lymphocyte population are associated with the development of multiple organ dysfunction syndrome in trauma patients . Critical Care vol. 20 , ( 1 )
Stoenchev KV, Pennington DJ ( 2016 ) . Structure and Function of TCRγδ Receptors . Encyclopedia of Immunobiology , vol. 2 ,
Muñoz-Ruiz M, Ribot JC, Grosso AR, Gonçalves-Sousa N, Pamplona A, Pennington DJ, Regueiro JR, Fernández-Malavé E et al. ( 2016 ) . TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets . Nature immunology
Escorcio-Correia M, Provan A, Pennington DJ ( 2015 ) . Immune Profiling of Immune Thrombocytopenia (ITP) Patients: Evidence for CD8 T Cell Involvement in the Disease . Blood . vol. 126 , 2259 - 2259 .
Torrance HDT, Brohi K, Warnes G, Owen HC, Hinds CJ, Pennington DJ, O’Dwyer MJ ( 2015 ) . T-helper cell polarisation following severe polytrauma . Intensive Care Medicine Experimental vol. 3 ,
Leslie RD, Dang MA, Hawa MI, Cunningham S, Bradford CM, Lowe R, Paul DM, Libertini E et al. ( 2015 ) . DNA Methylation Variation in Type 1 Diabetes Mellitus . DIABETES . vol. 64 , A81 - A81 .
Rei M, Pennington DJ, Silva-Santos B ( 2015 ) . The emerging protumor role of γδ T lymphocytes: Implications for cancer immunotherapy . Cancer Research vol. 75 , ( 5 ) 798 - 802 .
Sumaria N, Grandjean CLA, Pang DJ, Neves JF, Stoenchev KV, Silva-Santos B, Pennington DJ ( 2014 ) . A requirement for PI3K in gamma delta T-cell development . IMMUNOLOGY . vol. 143 , 53 - 53 .
Turner MD, Nedjai B, Hurst T, Pennington DJ ( 2014 ) . Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease . Biochim Biophys Acta vol. 1843 , ( 11 ) 2563 - 2582 .
Rei M, Gonçalves-Sousa N, Lança T, Thompson RG, Mensurado S, Balkwill FR, Kulbe H, Pennington DJ et al. ( 2014 ) . Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages . Proc Natl Acad Sci U S A vol. 111 , ( 34 ) E3562 - E3570 .
Dorronsoro A, Ferrin I, Salcedo JM, Jakobsson E, Fernández-Rueda J, Lang V, Sepulveda P, Fechter K et al. ( 2014 ) . Human mesenchymal stromal cells modulate T-cell responses through TNF-α-mediated activation of NF-κB . Eur J Immunol vol. 44 , ( 2 ) 480 - 488 .
Schmolka N, Serre K, Grosso AR, Rei M, Pennington DJ, Gomes AQ, Silva-Santos B ( 2013 ) . Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets . Nat Immunol vol. 14 , ( 10 ) 1093 - 1100 .
Prinz I, Silva-Santos B, Pennington DJ ( 2013 ) . Functional development of γδ T cells . Eur J Immunol vol. 43 , ( 8 ) 1988 - 1994 .
Coquet JM, Ribot JC, Bąbała N, Middendorp S, van der Horst G, Xiao Y, Neves JF, Fonseca-Pereira D et al. ( 2013 ) . Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway . J Exp Med vol. 210 , ( 4 ) 715 - 728 .
Michel M-L, Pang DJ, Haque SFY, Potocnik AJ, Pennington DJ, Hayday AC ( 2012 ) . Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells . Proc Natl Acad Sci U S A vol. 109 , ( 43 ) 17549 - 17554 .
Ribot JC, Coquet JM, Middendorp S, van der Horst G, Babala N, Neves JF, Pennington DJ, Jacobs HB et al. ( 2012 ) . CD70-CD27 interactions promote CD4(+)Foxp3(+) regulatory T cell development in the thymic medulla . IMMUNOLOGY . vol. 137 , 37 - 37 .
Sumaria N, Pang DJ, Neves JF, Stoenchev KV, Silva-Santos B, Pennington DJ ( 2012 ) . TCR requirements for gamma delta T cell development . IMMUNOLOGY . vol. 137 , 402 - 403 .
Grandjean CLA, Mahtani-Patching J, Pang DJ, Pennington DJ ( 2012 ) . The role of pTalpha isoforms in alpha beta T cell development . IMMUNOLOGY . vol. 137 , 369 - 369 .
Pang DJ, Neves JF, Sumaria N, Pennington DJ ( 2012 ) . Understanding the complexity of γδ T-cell subsets in mouse and human . Immunology vol. 136 , ( 3 ) 283 - 290 .
Turchinovich G, Pennington DJ ( 2011 ) . T cell receptor signalling in γδ cell development: strength isn't everything . Trends Immunol vol. 32 , ( 12 ) 567 - 573 .
Mahtani-Patching J, Neves JF, Pang DJ, Stoenchev KV, Aguirre-Blanco AM, Silva-Santos B, Pennington DJ ( 2011 ) . PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization . Sci Signal vol. 4 , ( 182 )
Cárcamo-Orive I, Gaztelumendi A, Delgado J, Tejados N, Dorronsoro A, Fernández-Rueda J, Pennington DJ, Trigueros C ( 2010 ) . Regulation of human bone marrow stromal cell proliferation and differentiation capacity by glucocorticoid receptor and AP-1 crosstalk . J Bone Miner Res vol. 25 , ( 10 ) 2115 - 2125 .
Afifi A, Raja SG, Pennington DJ, Tsang VT ( 2010 ) . For neonates undergoing cardiac surgery does thymectomy as opposed to thymic preservation have any adverse immunological consequences? . Interact Cardiovasc Thorac Surg vol. 11 , ( 3 ) 287 - 291 .
Sengupta N, MacFie TS, MacDonald TT, Pennington D, Silver AR ( 2010 ) . Cancer immunoediting and "spontaneous" tumor regression . Pathol Res Pract vol. 206 , ( 1 ) 1 - 8 .
Ribot JC, deBarros A, Pang DJ, Neves JF, Peperzak V, Roberts SJ, Girardi M, Borst J et al. ( 2009 ) . CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets . Nat Immunol vol. 10 , ( 4 ) 427 - 436 .
McKnight A, Pennington DJ ( 2009 ) . HIV Vaccine Approaches . Encyclopedia of Life Sciences , John Wiley & Sons, Ltd: Chichester.
Sancho D, Mourão-Sá D, Joffre OP, Schulz O, Rogers NC, Pennington DJ, Carlyle JR, Reis e Sousa C ( 2008 ) . Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin . J Clin Invest vol. 118 , ( 6 ) 2098 - 2110 .
Hunt KA, Zhernakova A, Turner G, Heap GAR, Franke L, Bruinenberg M, Romanos J, Dinesen LC et al. ( 2008 ) . Newly identified genetic risk variants for celiac disease related to the immune response . Nat Genet vol. 40 , ( 4 ) 395 - 402 .
Hayday AC, Pennington DJ ( 2007 ) . Key factors in the organized chaos of early T cell development . Nat Immunol vol. 8 , ( 2 ) 137 - 144 .
Pennington DJ, Silva-Santos B, Silberzahn T, Escorcio-Correia M, Woodward MJ, Roberts SJ, Smith AL, Dyson PJ et al. ( 2006 ) . Early events in the thymus affect the balance of effector and regulatory T cells . NATURE vol. 444 , ( 7122 ) 1073 - 1077 .
Pennington DJ, Silva-Santos B, Correia M, Hayday AC ( 2005 ) . The regulation of gamma delta cell functional potential by alpha alpha beta T cell progenitors in the thymus . IMMUNOLOGY vol. 116 , 88 - 88 .
Pennington DJ, Silva-Santos B, Hayday AC ( 2005 ) . Gammadelta T cell development--having the strength to get there . Curr Opin Immunol vol. 17 , ( 2 ) 108 - 115 .
Silva-Santos B, Pennington DJ, Hayday AC ( 2005 ) . Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors . Science vol. 307 , ( 5711 ) 925 - 928 .
Pennington DJ, Vermijlen D, Wise EL, Clarke SL, Tigelaar RE, Hayday AC ( 2005 ) . The integration of conventional and unconventional T cells that characterizes cell-mediated responses . Adv Immunol vol. 87 , 27 - 59 .
Comalada M, Xaus J, Valledor AF, López-López C, Pennington DJ, Celada A ( 2003 ) . PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in macrophages . Am J Physiol Cell Physiol vol. 285 , ( 5 ) C1235 - C1245 .
Pennington DJ, Silva-Santos B, Shires J, Theodoridis E, Pollitt C, Wise EL, Tigelaar RE, Owen MJ et al. ( 2003 ) . The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells . Nat Immunol vol. 4 , ( 10 ) 991 - 998 .
Hayday AC, Pennington DJ, Giuggio VM ( 2003 ) . Genomics and immunology . Semin Immunol vol. 15 , ( 4 ) 201 - 208 .
Trigueros C, Hozumi K, Silva-Santos B, Bruno L, Hayday AC, Owen MJ, Pennington DJ ( 2003 ) . Pre-TCR signaling regulates IL-7 receptor alpha expression promoting thymocyte survival at the transition from the double-negative to double-positive stage . Eur J Immunol vol. 33 , ( 7 ) 1968 - 1977 .
Aliberti J, Schulz O, Pennington DJ, Tsujimura H, Reis e Sousa C, Ozato K, Sher A ( 2003 ) . Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells . Blood vol. 101 , ( 1 ) 305 - 310 .
Saurin AT, Pennington DJ, Raat NJH, Latchman DS, Owen MJ, Marber MS ( 2002 ) . Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts . Cardiovasc Res vol. 55 , ( 3 ) 672 - 680 .
Leask A, Abraham DJ, Finlay DR, Holmes A, Pennington D, Shi-Wen X, Chen Y, Venstrom K et al. ( 2002 ) . Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts . Arthritis Rheum vol. 46 , ( 7 ) 1857 - 1865 .
Schulz O, Pennington DJ, Hodivala-Dilke K, Febbraio M, Reis e Sousa C ( 2002 ) . CD36 or alphavbeta3 and alphavbeta5 integrins are not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ murine dendritic cells . J Immunol vol. 168 , ( 12 ) 6057 - 6065 .
Holmes A, Shi-Wen X, Ponticos M, Rajkumar V, Pennington D, Mukerjee D, Abraham DJ, Black CM ( 2002 ) . CONNECTIVE TISSUE GROWTH FACTOR PRODUCED BY LUNG FIBROBLASTS IN RESPONSE TO INJURY MEDIATES EXTRACELLULAR MATRIX DEPOSITION IN BLEOMYCIN-INDUCED LUNG FIBROSIS . RHEUMATOLOGY vol. 41 , 58 - 58 .
Castrillo A, Pennington DJ, Otto F, Parker PJ, Owen MJ, Boscá L ( 2001 ) . Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection . J Exp Med vol. 194 , ( 9 ) 1231 - 1242 .
Saurin AT, Pennington DJ, Raat H, Owen MJ, Marber MS ( 2000 ) . Ischemic preconditioning in isolated mouse hearts - An essential role for PKC-epsilon . CIRCULATION vol. 102 , ( 18 ) 155 - 155 .
Shi-wen X, Pennington D, Holmes A, Leask A, Bradham D, Beauchamp JR, Fonseca C, du Bois RM et al. ( 2000 ) . Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis . Exp Cell Res vol. 259 , ( 1 ) 213 - 224 .
Buckland J, Pennington DJ, Bruno L, Owen MJ ( 2000 ) . Correction: Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development (European Journal of Immunology) (2000) 30, 1 (8-18)) . European Journal of Immunology vol. 30 , ( 3 )
Buckland J, Pennington DJ, Bruno L, Owen MJ ( 2000 ) . Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development . Eur J Immunol vol. 30 , ( 1 ) 8 - 18 .
Holmes A, Fonseca C, Pennington D, Shiwen X, Rajkumar V, Black C, Abraham D ( 1999 ) . Identification of over expressed genes involved in the maintance of fibrosis: representational difference analysis of scleroderma fibroblasts . ARTHRITIS RHEUM vol. 42 , ( 9 ) S203 - S203 .
Pennington DJ, Jenkins SA, Brady HJ, Miles CG, Dzierzak EA, Abraham DJ ( 1997 ) . HIV- I Nef severely impairs thymocyte development and peripheral T-cell function by a CD4-independent mechanism . Genes Funct vol. 1 , ( 5-6 ) 321 - 335 .
Brady HJ, Abraham DJ, Pennington DJ, Miles CG, Jenkins S, Dzierzak EA ( 1995 ) . Altered cytokine expression in T lymphocytes from human immunodeficiency virus Tat transgenic mice . J Virol vol. 69 , ( 12 ) 7622 - 7629 .
ABRAHAM D, PENNINGTON D, MILES C, JENKINS S, BRADY H, DZIERZAK E ( 1995 ) . T-CELLS FROM HIV-1 TAT TRANSGENIC MICE SHOW ALTERED CYTOKINE EXPRESSION . J CELL BIOCHEM200 - 200 .
Brady HJ, Pennington DJ, Dzierzak EA ( 1994 ) . Transgenic mice as models of human immunodeficiency virus expression and related cellular effects . J Gen Virol vol. 75 ( Pt 10) , 2549 - 2558 .
Brady HJ, Miles CG, Pennington DJ, Dzierzak EA ( 1994 ) . Specific ablation of human immunodeficiency virus Tat-expressing cells by conditionally toxic retroviruses . Proc Natl Acad Sci U S A vol. 91 , ( 1 ) 365 - 369 .
Brady HJ, Pennington DJ, Miles CG, Dzierzak EA ( 1993 ) . CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration . EMBO J vol. 12 , ( 13 ) 4923 - 4932 .
Brady HJ, Miles CG, Pennington DJ, Dzierzak EA ( 1993 ) . Studies of HIV-2 promoter activity and cell specific ablation . Leukemia vol. 7 Suppl 2 , S61 - S65 .
DZIERZAK EA, MILES C, PENNINGTON D, BRADY HJM ( 1993 ) . SPECIFIC ABLATION OF HIV-TAT EXPRESSING CELLS BY CONDITIONALLY TOXIC RETROVIRUSES . J CELL BIOCHEM249 - 249 .