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Research

Publications: Prof Yaohe Wang

Marelli G, Chard Dunmall LS, Yuan M, Di Gioia C, Miao J, Cheng Z, Zhang Z, Liu P et al. ( 2021 ) . A systemically deliverable Vaccinia virus with increased capacity for intertumoral and intratumoral spread effectively treats pancreatic cancer . Journal for ImmunoTherapy of Cancer vol. 9 , ( 1 )
Ahmed J, Chard LS, Yuan M, Wang J, Howells A, Li Y, Li H, Zhang Z et al. ( 2020 ) . Erratum: A new oncolytic Vaccinia virus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery (J ImmunoTher Cancer (2020) 8 (e000415) DOI: 10.1136/jitc-2019-000415) . Journal for ImmunoTherapy of Cancer vol. 8 , ( 1 )
Ahmed J, Chard LS, Yuan M, Wang J, Howells A, Li Y, Li H, Zhang Z et al. ( 2020 ) . A new oncolytic v accinia virus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery . Journal for ImmunoTherapy of Cancer vol. 8 , ( 1 )
Ferguson MS, Chard Dunmall LS, Gangeswaran R, Marelli G, Tysome JR, Burns E, Whitehead MA, Aksoy E et al. ( 2020 ) . Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus . Molecular Therapy vol. 28 , ( 5 ) 1263 - 1275 .
Cutmore LC, Brown NF, Raj D, Chauduri S, Wang P, Maher J, Wang Y, Lemoine NR et al. ( 2020 ) . Pancreatic Cancer UK Grand Challenge: Developments and challenges for effective CAR T cell therapy for pancreatic ductal adenocarcinoma . Pancreatology
Lu S, Zhang Z, Du P, Chard LS, Yan W, Khouri ME, Wang Z, Zhang Z et al. ( 2020 ) . A virus-infected, reprogrammed somatic cell–derived tumor cell (VIREST) vaccination regime can prevent initiation and progression of pancreatic cancer . Clinical Cancer Research vol. 26 , ( 2 ) 465 - 476 .
Miao J, Chard LS, Wang Z, Wang Y ( 2019 ) . Syrian Hamster as an Animal Model for the Study on Infectious Diseases . Frontiers in Immunology vol. 10 ,
Hallden G, Wang Y, Wong H-H, Lemoine NR ( 2019 ) . ONCOLYTIC ADENOVIRUSES FOR CANCER GENE THERAPY . Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology ,
Di Gioia C, Yuan M, Wang Y ( 2019 ) . Vaccinia Virus Genome Editing Using CRISPR . vol. 2023 , 109 - 117 .
Butcher K, Kannappan V, Azar K, Kilari R, Nkeonye O, Morris MR, McConville C, Wang Y et al. ( 2018 ) . Abstract 1975: Disulfiram targets hypoxia-induced cancer stem cells and reverses chemoresistance in non-small cell lung cancer . 1975 - 1975 .
Miao J, Ying B, Li R, Tollefson AE, Spencer JF, Wold WSM, Song SH, Kong IK et al. ( 2018 ) . Characterization of an n-terminal non-core domain of RAG1 gene disrupted Syrian hamster model generated by CRISPR cas9 . Viruses vol. 10 , ( 5 )
Marelli G, Howells A, Lemoine NR, Wang Y ( 2018 ) . Oncolytic Viral Therapy and the Immune System: A Double-Edged Sword Against Cancer . Frontiers in Immunology vol. 9 , 866 - 866 .
Wang P, Li X, Wang J, Gao D, Li Y, Li H, Chu Y, Zhang Z et al. ( 2018 ) . Erratum: Author Correction: Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent (Nature communications (2017) 8 1 (1395)) . Nature communications vol. 9 , ( 1 )
Li R, Miao J, Fan Z, Song S, Kong IK, Wang Y, Wang Z ( 2018 ) . Production of genetically engineered golden syrian hamsters by pronuclear injection of the CRISPR/Cas9 complex . Journal of Visualized Experiments vol. 2018 , ( 131 )
Delaunay T, Violland M, Boisgerault N, Dutoit S, Vignard V, Münz C, Gannage M, Dréno B et al. ( 2017 ) . Oncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells . Oncoimmunology vol. 7 , ( 3 ) e1407897 - e1407897 .
Vincent D, Kramberger P, Hudej R, Štrancar A, Wang Y, Zhou Y, Velayudhan A ( 2017 ) . The development of a monolith-based purification process for Orthopoxvirus vaccinia virus Lister strain . Journal of Chromatography A vol. 1524 , 87 - 100 .
Wang P, Li X, Wang J, Gao D, Li Y, Li H, Chu Y, Zhang Z et al. ( 2017 ) . Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent . Nat Commun vol. 8 , ( 1 ) 1395 - 1395 .
Spurrell E, Gangeswaran R, Wang P, Cao F, Gao D, Feng B, Wold W, Tollefson A et al. ( 2017 ) . Erratum: STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus [Journal of Virology, 88, 4, (2014) (2291-2300)] DOI: 10.1128/JVI.02829-13 . Journal of Virology vol. 91 , ( 20 )
Howells A, Marelli G, Lemoine NR, Wang Y ( 2017 ) . Oncolytic Viruses-Interaction of Virus and Tumor Cells in the Battle to Eliminate Cancer . Front Oncol vol. 7 , 195 - 195 .
Cui B, Cao X, Zou W, Wan Y, Wang N, Wang Y, Li P, Hua F et al. ( 2017 ) . Regulation of immune-related diseases by multiple factors of chromatin, exosomes, microparticles, vaccines, oxidative stress, dormancy, protein quality control, inflammation and microenvironment: a meeting report of 2017 International Workshop of the Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine on Tumor Immunology . Acta Pharmaceutica Sinica B vol. 7 , ( 4 ) 532 - 540 .
Lu S, Ahmed T, Du P, Wang Y ( 2017 ) . Genomic Variations in Pancreatic Cancer and Potential Opportunities for Development of New Approaches for Diagnosis and Treatment . Int J Mol Sci vol. 18 , ( 6 )
Webb ES, Liu P, BALEEIRO R, Lemoine NR, Yuan M, Wang Y ( 2017 ) . Immune checkpoint inhibitors in cancer therapy . Journal of Biomedical Research
Liu S, Ruban L, Wang Y, Zhou Y, Nesbeth DN ( 2017 ) . Establishing elements of a synthetic biology platform for Vaccinia virus production: BioBrick™ design, serum-free virus production and microcarrier-based cultivation of CV-1 cells . Heliyon vol. 3 , ( 2 ) e00238 - e00238 .
Wang Z, Wang Y, Wang S, Zhang LR, Zhang N, Cheng Z, Liu Q, Shields KJ et al. ( 2017 ) . CRISPR-Cas9 HDR system enhances AQP1 gene expression . Oncotarget vol. 8 , ( 67 ) 111683 - 111696 .
Li X, Wang P, Li H, Du X, Liu M, Huang Q, Wang Y, Wang S ( 2017 ) . The efficacy of oncolytic adenovirus is mediated by T-cell responses against virus and tumor in Syrian hamster model . Clinical Cancer Research vol. 23 , ( 1 ) 239 - 249 .
Yuan M, Wang P, Chard LS, Lemoine NR, Wang Y ( 2016 ) . A simple and efficient approach to construct mutant vaccinia virus vectors . Journal of Visualized Experiments vol. 2016 , ( 116 )
Yuan M, Webb E, Lemoine NR, Wang Y ( 2016 ) . CRISPR-Cas9 as a powerful tool for efficient creation of oncolytic viruses . Viruses vol. 8 , ( 3 )
Ibrahim AM, Wang YH ( 2016 ) . VIRO-immune therapy: A new strategy for treatment of pancreatic cancer . World Journal of Gastroenterology vol. 22 , ( 2 ) 748 - 763 .
Yaghchi CA, Zhang Z, Alusi G, Lemoine NR, Wang Y ( 2015 ) . Vaccinia virus, a promising new therapeutic agent for pancreatic cancer . Immunotherapy vol. 7 , ( 12 ) 1249 - 1258 .
Browne A, Tookman LA, Ingemarsdotter CK, Bouwman RD, Pirlo K, Wang Y, McNeish IA, Lockley M ( 2015 ) . Pharmacological inhibition of β<inf>3</inf> integrin reduces the inflammatory toxicities caused by oncolytic adenovirus without compromising anticancer activity . Cancer Research vol. 75 , ( 14 ) 2811 - 2821 .
Ferguson M, Tysome J, Burns E, Whitehead M, Aksoy E, Clear A, Alusi G, Hiley C et al. ( 2015 ) . 649. Targeting Innate Host Immunity Through PI3K Delta for Enhancement of Systemic Delivery of Oncolytic Vaccinia Virus . Molecular Therapy . vol. 23 , s258 - s259 .
Yuan M, Gao X, Chard LS, Ali Z, Ahmed J, Li Y, Liu P, Lemoine NR et al. ( 2015 ) . A marker-free system for highly efficient construction of vaccinia virus vectors using CRISPR Cas9 . Molecular Therapy - Methods and Clinical Development vol. 2 ,
Hughes JP, Alusi G, Wang Y ( 2015 ) . Viral gene therapy for head and neck cancer . Journal of Laryngology and Otology vol. 129 , ( 4 ) 314 - 320 .
Hughes J, Wang P, Alusi G, Shi H, Chu Y, Wang J, Bhakta V, McNeish I et al. ( 2015 ) . Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus . Gene Therapy
Hughes JP, Alusi G, Wang Y ( 2015 ) . Viral gene therapy for head and neck cancer . Journal of Laryngology and Otology
Chard LS, Maniati E, Wang P, Zhang Z, Gao D, Wang J, Cao F, Ahmed J et al. ( 2015 ) . A vaccinia virus armed with interleukin-10 Is a promising therapeutic agent for treatment of murine pancreatic cancer . Clinical Cancer Research vol. 21 , ( 2 ) 405 - 416 .
Yuan M, Zhang W, Wang J, Al Yaghchi C, Ahmed J, Chard L, Lemoine NR, Wang Y ( 2015 ) . Efficiently editing the vaccinia virus genome by using the CRISPR-Cas9 system . Journal of Virology vol. 89 , ( 9 ) 5176 - 5179 .
Ibrahim AM, Wang Y, Lemoine NR ( 2015 ) . Immune-checkpoint blockade: The springboard for immuno-combination therapy . Gene Therapy vol. 22 , ( 11 ) 849 - 850 .
Hughes J, Wang P, Alusi G, Shi H, Chu Y, Wang J, Bhakta V, McNeish I et al. ( 2015 ) . Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus . Gene Therapy vol. 22 , ( 6 ) 476 - 484 .
Chard LS, Lemoine NR, Wang Y ( 2015 ) . New role of Interleukin-10 in enhancing the antitumor efficacy of oncolytic vaccinia virus for treatment of pancreatic cancer . OncoImmunology vol. 4 , ( 9 ) 1 - 3 .
Hughes J, Wang P, Alusi G, Bhakta V, Chu Y, Shi H, McNeish I, McCart A et al. ( 2014 ) . Backbone selection for development of tumour-targeted oncolyti Vaccinia virus for cancer treatment . HUMAN GENE THERAPY . vol. 25 , A22 - A23 .
Ahmed J, Yuan M, Li Y, Chu Y, Shi H, Chard L, Alusi G, Lemoine N et al. ( 2014 ) . A Novel Tumour Selective Oncolytic Vaccinia Virus Lacking the N1L Gene Enhances the Anti-Tumour Immune Response When Used as an Anticancer Therapeutic . MOLECULAR THERAPY . vol. 22 , S248 - S249 .
Spurrell E, Gangeswaran R, Wang P, Cao F, Gao D, Feng B, Wold W, Tollefson A et al. ( 2014 ) . STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus . Journal of Virology vol. 88 , ( 4 ) 2291 - 2300 .
Hallden G, Wang Y, Wong H-H, Lemoine NR ( 2014 ) . 18: ONCOLYTIC ADENOVIRUSES FOR CANCER GENE THERAPY . Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology , vol. 1 ,
Ahmed J, Yuan M, Alusi G, Lemoine NR, Wang Y ( 2014 ) . Chapter 16 The Lister Strain of Vaccinia Virus as an Anticancer Therapeutic Agent . Gene Therapy of Cancer ,
Chard LS, Maniati E, Wang P, Hughes J, Wang J, Denes B, Fodor I, Hagemann T et al. ( 2013 ) . A Vaccinia Virus Armed with Interleukin-10 That Dampens Host Immunity to the Vctor but Not to Tumor Is a Promising Therapeutic Agent for Pancreatic Cancer . MOLECULAR THERAPY . vol. 21 , S196 - S196 .
Hughes J, Wang P, Alusi G, Bhakta V, Chu Y, Shi H, McNeish I, McCart A et al. ( 2013 ) . Lister Strain Vaccinia Virus Demonstrates Favourable Anti-Tumor Efficacy and Tumor-Selectivity Compared to Western Reserve Strain . MOLECULAR THERAPY . vol. 21 , S216 - S216 .
Cheung W, Nowrouzi A, Coutelle C, Waddington S, Bigger B, Al Alaf F, Thrasher A, Andrews R et al. ( 2013 ) . The fetal mouse is a model of genotoxicity that can uncover genes involved in liver cancer . HUMAN GENE THERAPY . vol. 24 , A15 - A16 .
Hiley CT, Chard LS, Gangeswaran R, Tysome JR, Briat A, Lemoine NR, Wang Y ( 2013 ) . Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway . J Virol vol. 87 , ( 5 ) 2781 - 2790 .
Nowrouzi A, Cheung WT, Li T, Zhang X, Arens A, Paruzynski A, Waddington SN, Osejindu E et al. ( 2013 ) . The Fetal Mouse Is a Sensitive Genotoxicity Model That Exposes Lentiviral-associated Mutagenesis Resulting in Liver Oncogenesis . MOLECULAR THERAPY vol. 21 , ( 2 ) 324 - 337 .
Ahmed J, Yuan M, Alusi G, Lemoine NR, Wang Y ( 2013 ) . The Lister Strain of Vaccinia Virus as an Anticancer Therapeutic Agent . Gene Therapy of Cancer: Translational Approaches from Preclinical Studies to Clinical Implementation: Third Edition ,
Tysome JR, Lemoine NR, Wang Y ( 2013 ) . Update on oncolytic viral therapy - targeting angiogenesis . Onco Targets Ther vol. 6 , 1031 - 1040 .
Tysome JR, Li X, Wang S, Wang P, Gao D, Du P, Chen D, Gangeswaran R et al. ( 2012 ) . A novel therapeutic regimen to eradicate established solid tumors with an effective induction of tumor-specific immunity . Clin Cancer Res vol. 18 , ( 24 ) 6679 - 6689 .
Ferguson MS, Lemoine NR, Wang Y ( 2012 ) . Systemic delivery of oncolytic viruses: Hopes and hurdles . Advances in Virology vol. 2012 ,
Hiley CT, Chard L, Tysome J, Briat A, Lemoine NR, Wang Y ( 2012 ) . Abstract A37: Increased efficacy of oncolytic vaccinia virus, an emerging therapy for pancreatic adenocarcinoma, due to intratumoral hypoxia and vascular endothelial growth factor A . a37 - a37 .
Hughes J, Alusi G, Wang Y ( 2012 ) . Gene therapy and nasopharyngeal carcinoma . RHINOLOGY vol. 50 , ( 2 ) 115 - 121 .
Wang P, Jiang G, Chard L, Wang J, Gao D, Cao H, Lemoine NR, Wang Y ( 2012 ) . A Rationally Designed Oncolytic Adenovirus, Ad-TD-IL-12, Cures Pancreatic Cancer in the Immunocompetent Syrian Hamster . MOLECULAR THERAPY . vol. 20 , S131 - S131 .
Yang Y, Li X, Wang Y, Wang S ( 2012 ) . Abstract LB-129: CD8+ T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model .
YaJun Y, XiaoZhu L, YaoHe W, ShengDian W ( 2012 ) . CD8(+) T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model . CHINESE SCIENCE BULLETIN vol. 57 , ( 1 ) 48 - 53 .
WANG Y ( 2012 ) . Modification of the Early Gene Enhancer-promoter Improves the Oncolytic Potency of Adenovirus 11 . Mol Ther vol. 20 , ( 2 ) 306 - 16 .
Tysome JR, Wang P, Alusi G, Briat A, Gangeswaran R, Wang J, Bhakta V, Fodor I et al. ( 2011 ) . Lister vaccine strain of vaccinia virus armed with the endostatin-angiostatin fusion gene: an oncolytic virus superior to dl1520 (ONYX-015) for human head and neck cancer . Hum Gene Ther vol. 22 , ( 9 ) 1101 - 1108 .
Jiang G, Cao F, Ren G, Gao D, Bhakta V, Zhang Y, Cao H, Dong Z et al. ( 2010 ) . PRSS3 promotes tumour growth and metastasis of human pancreatic cancer . Gut vol. 59 , ( 11 ) 1535 - 1544 .
Hiley CT, Briat A, Puttaswamaiah G, Wong HH, Lemoine NR, Wang Y ( 2010 ) . Abstract 589: Vascular endothelial growth factor facilitates vaccinia virus tropism and oncolysis in human pancreatic ductal adenocarcinoma . 589 - 589 .
Hiley CT, Yuan M, Lemoine NR, Wang Y ( 2010 ) . Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours . Gene Ther vol. 17 , ( 2 ) 281 - 287 .
Wong HH, Lemoine NR, Wang Y ( 2010 ) . Oncolytic viruses for cancer therapy: overcoming the obstacles . Viruses vol. 2 , ( 1 ) 78 - 106 .
Tysome JR, Lemoine NR, Wang YH ( 2009 ) . Combination of anti-angiogenic therapy and virotherapy: Arming oncolytic viruses with anti-angiogenic genes . CURR OPIN MOL THER vol. 11 , ( 6 ) 664 - 669 .
Tysome JR, Briat A, Alusi G, Cao F, Gao D, Yu J, Wang P, Yang S et al. ( 2009 ) . Lister strain of vaccinia virus armed with endostatin-angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancer . Gene Therapy vol. 16 , ( 10 ) 1223 - 1233 .
Wang YH, Gangeswaran R, Zhao XB, Wang PJ, Tysome J, Bhakta V, Yuan M, Chikkanna-Gowda CP et al. ( 2009 ) . CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells . J CLIN INVEST vol. 119 , ( 6 ) 1604 - 1615 .
Wong HH, Gangeswaran R, Francis J, Lemoine NR, Wang Y ( 2009 ) . Adenovirus 11 is an Alternative Oncolytic Virus Targeting Adenovirus 5-Insensitive Cancer and Shows Distinct E1A Gene Transcriptional Activity . MOLECULAR THERAPY . vol. 17 , S235 - S236 .
Tysome JR, Briat A, Hiley C, Gangeswaran R, Chikkanna-Gowda CP, Bhakta V, Alusi G, Trivedi K et al. ( 2009 ) . Systemic Delivery of Lister Strain Vaccinia Virus to Tumors Is Facilitated by the Depletion of Macrophages in Immuno-Competent Mice . MOLECULAR THERAPY . vol. 17 , S247 - S247 .
Tysome JR, Briat A, Alusi G, Cao F, Yu J, Wang P, Yang S, Dong Z et al. ( 2009 ) . Lister strain of vaccinia virus armed with endostatin–angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancerVaccine strain of vaccinia virus for cancer therapy . Gene Therapy vol. 16 , ( 10 ) 1223 - 1233 .
Tysome JR, Alusi G, Lemoine N, Wang Y ( 2008 ) . Oncolytic Vaccinia Virus Gene Therapy for HNSCC . Otolaryngology vol. 139 , ( 2 ) p92 - p93 .
Kirn DH, Wang YH, Liang WC, Contag CH, Thorne SH ( 2008 ) . Enhancing poxvirus oncolytic effects through increased spread and immune evasion . CANCER RES vol. 68 , ( 7 ) 2071 - 2075 .
Cheong SC, Wang Y, Meng J-H, Hill R, Sweeney K, Kirn D, Lemoine NR, Halldén G ( 2008 ) . E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models . Cancer Gene Ther vol. 15 , ( 1 ) 40 - 50 .
Kirn DH, Wang YH, Le Boeuf F, Bell J, Thorne SH ( 2007 ) . Targeting of interferon-beta to produce a specific, multi-mechanistic oncolytic vaccinia virus . PLOS MED vol. 4 , ( 12 ) Article e353 , 2001 - 2012 .
Thorne SH, Hwang THH, O'Gorman WE, Bartlett DL, Sei S, Kanji F, Brown C, Werier J et al. ( 2007 ) . Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963 . J CLIN INVEST vol. 117 , ( 11 ) 3350 - 3358 .
Lopes RB, Gangeswaran R, McNeish IA, Wang Y, Lemoine NR ( 2007 ) . Expression of the IAP protein family is dysregulated in pancreatic cancer cells and is important for resistance to chemotherapy . Int J Cancer vol. 120 , ( 11 ) 2344 - 2352 .
Bapat U, Wang Y, Alusi G, Chisholm E, Francis J, Hallden G, Lemoine N ( 2006 ) . Oncolytic virotherapy for nasopharyngeal cancer . Clinical Otolaryngology vol. 31 , ( 6 ) 582 - 583 .
Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F, Gregory L, Nivsarkar M et al. ( 2006 ) . Oncogenesis Following Delivery of Lentiviral Vectors to Fetal and Neonatal Mice . MOLECULAR THERAPY vol. 13 , S320 - S320 .
Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F, Gregory LG, Nivsarkar M et al. ( 2006 ) . Erratum: "Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice" (Molecular Therapy (2005) vol. 12 (763-771) 10.1016/j.ymthe.2005.07.358) . Molecular Therapy vol. 13 , ( 4 )
Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F, Gregory LG, Nivsarkar M et al. ( 2006 ) . Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice (vol 12, pg 763, 2005) . MOL THER vol. 13 , ( 4 ) 830 - 830 .
Slettenaar VIF, Van Trappen PO, Wang Y, Ayhan A, Li FN, Balkwill F, Wilson JL ( 2006 ) . The chemokine network in normal and malignant cervix: CCR4 expression by malignant human cervical epithelial cells . CANCER RESEARCH . vol. 66 ,
Themis M, Waddington SN, Schmidt M, von Kalle C, Wang YH, Al-Allaf F, Gregory L, Nivsarkar M et al. ( 2006 ) . Oncogenesis following delivery of a non-primate lentiviral gene therapy vector to fetal mice . TOXICOLOGY . vol. 219 , 233 - 233 .
Lockley M, Fernandez M, Wang Y, Li NF, Conroy S, Lemoine N, McNeish I ( 2006 ) . Activity of the adenoviral E1A deletion mutant dl922-947 in ovarian cancer: comparison with E1A wild-type viruses, bioluminescence monitoring, and intraperitoneal delivery in icodextrin . Cancer Res vol. 66 , ( 2 ) 989 - 998 .
Themis M, Waddington SN, Schmidt M, von Kalle C, Wang YH, Al-Allaf F, Gregory LG, Nivsarkar M et al. ( 2005 ) . Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice . MOL THER vol. 12 , ( 4 ) 763 - 771 .
Liu T-C, Wang Y, Hallden G, Brooks G, Francis J, Lemoine NR, Kirn D ( 2005 ) . Functional interactions of antiapoptotic proteins and tumor necrosis factor in the context of a replication-competent adenovirus . Gene Ther vol. 12 , ( 17 ) 1333 - 1346 .
Tan PH, Beutelspacher SC, Xue S-A, Wang Y-H, Mitchell P, McAlister JC, Larkin DFP, McClure MO et al. ( 2005 ) . Modulation of human dendritic-cell function following transduction with viral vectors: implications for gene therapy . Blood vol. 105 , ( 10 ) 3824 - 3832 .
Tan PH, Beutelspacher SC, Wang YH, McClure MO, Ritter MA, Lombardi G, George AJT ( 2005 ) . Immunolipoplexes: An efficient, non-viral alternative for transfection of human dendritic cells with potential for clinical vaccination . AMERICAN JOURNAL OF TRANSPLANTATION . vol. 5 , 367 - 367 .
Tan PH, Beutelspacher SC, Wang Y-H, McClure MO, Ritter MA, Lombardi G, George AJT ( 2005 ) . Immunolipoplexes: an efficient, nonviral alternative for transfection of human dendritic cells with potential for clinical vaccination . Mol Ther vol. 11 , ( 5 ) 790 - 800 .
Tan PH, Xue SA, Wang YH, Beutelspacher SC, McAlister JC, Larkin DFP, McClure MO, Stauss HJ et al. ( 2005 ) . Modulation of human dendritic cell function following viral vectors: implications for gene therapy in vaccination . BRITISH JOURNAL OF SURGERY . vol. 92 , 134 - 134 .
Wang Y, Xue S-A, Hallden G, Francis J, Yuan M, Griffin BE, Lemoine NR ( 2005 ) . Virus-associated RNA I-deleted adenovirus, a potential oncolytic agent targeting EBV-associated tumors . Cancer Res vol. 65 , ( 4 ) 1523 - 1531 .
Wang Y, Thorne S, Hannock J, Francis J, Au T, Reid T, Lemoine N, Kirn D et al. ( 2005 ) . A novel assay to assess primary human cancer infectibility by replication-selective oncolytic adenoviruses . Clin Cancer Res vol. 11 , ( 1 ) 351 - 360 .
Missiaglia E, Blaveri E, Terris B, Wang Y-H, Costello E, Neoptolemos JP, Crnogorac-Jurcevic T, Lemoine NR ( 2004 ) . Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis . Int J Cancer vol. 112 , ( 1 ) 100 - 112 .
Groot-Wassink T, Aboagye EO, Wang Y, Lemoine NR, Keith WN, Vassaux G ( 2004 ) . Noninvasive imaging of the transcriptional activities of human telomerase promoter fragments in mice . Cancer Res vol. 64 , ( 14 ) 4906 - 4911 .
Wang Y, Faux SP, Hallden G, Kirn DH, Houghton CE, Lemoine NR, Patrick G ( 2004 ) . Interleukin-1beta and tumour necrosis factor-alpha promote the transformation of human immortalised mesothelial cells by erionite . Int J Oncol vol. 25 , ( 1 ) 173 - 178 .
Liu T-C, Hallden G, Wang Y, Brooks G, Francis J, Lemoine N, Kirn D ( 2004 ) . An E1B-19 kDa gene deletion mutant adenovirus demonstrates tumor necrosis factor-enhanced cancer selectivity and enhanced oncolytic potency . Mol Ther vol. 9 , ( 6 ) 786 - 803 .
Hallden GK, Meng JH, Hill R, Wang YH, Francis J, Lemoine NN, Kirn DH ( 2004 ) . Combination therapy with adenovirus (Ad5) and cytotoxic drugs can act synergistically to induce cell death in carcinoma cell lines in culture . MOLECULAR THERAPY . vol. 9 , S113 - S113 .
Liu TC, Wang YH, Hallden G, Francis J, Brooks G, Lemoine N, Kirn D ( 2004 ) . Oncolytic adenovirus E1B-19kD deletion and E3B retention results in both enhanced potency and tumor necrosis factor-mediated selectivity . MOLECULAR THERAPY . vol. 9 , S109 - S109 .
Hill RJ, Hallden GK, Wang YH, Francis J, Simpson C, Kirn DH, Lemoine NR ( 2004 ) . The gene expression and function of adenoviral E3-genes in murine tumour cell lines . MOLECULAR THERAPY . vol. 9 , S374 - S375 .
Wang YH, Xue SA, Hallden G, Francis J, Griffin BE, Lemoine NR ( 2004 ) . VAI deleted adenovirus as an oncolytic agent targeting human EBV-associated tumours . MOLECULAR THERAPY . vol. 9 , S230 - S230 .
Groot-Wassink T, Aboagye EO, Wang Y, Lemoine NR, Reader AJ, Vassaux G ( 2004 ) . Quantitative imaging of Na/I symporter transgene expression using positron emission tomography in the living animal . Mol Ther vol. 9 , ( 3 ) 436 - 442 .
Wang Y, Hallden G, Hill R, Anand A, Liu T-C, Francis J, Brooks G, Lemoine N et al. ( 2003 ) . E3 gene manipulations affect oncolytic adenovirus activity in immunocompetent tumor models . Nat Biotechnol vol. 21 , ( 11 ) 1328 - 1335 .
Halldén G, Hill R, Wang Y, Anand A, Liu T-C, Lemoine NR, Francis J, Hawkins L et al. ( 2003 ) . Novel immunocompetent murine tumor models for the assessment of replication-competent oncolytic adenovirus efficacy . Mol Ther vol. 8 , ( 3 ) 412 - 424 .
Liu TC, Wang YH, Hallden G, Anand A, Lemoine NR, Kirn DH ( 2003 ) . Adenoviral E1B-19kD deletion results in enhanced oncolytic effect and reduced toxicity in an immunocompetent murine tumor . MOLECULAR THERAPY . vol. 7 , S416 - S416 .
Wang YH, Francis J, Griffin BE, Lemoine NLR, Xue SA ( 2003 ) . Cytotoxicity of replication-competent adenovirus to lymphoproliferative disorders correlates with expression of heparan sulfate . MOLECULAR THERAPY . vol. 7 , S359 - S359 .
Liu TC, Hallden G, Anand A, Wang YH, Lemoine N, Kirn D ( 2003 ) . Adenovirus E1B-19kD gene deletion enhances oncolytic virus efficacy and selectivity . CANCER GENE THERAPY . vol. 10 , S20 - S20 .
LEMOINE N, Vassaux G, Groot-Wassink T, Wang Y ( 2003 ) . Cellular characterisation of the tropism of recombinant adenovirus for the adrenal glands . Eur. J. Clin. Invest. vol. 33 , 794 - 798 .