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Research

Publications: Prof Timothy Warner

Palma-Barqueros V, Crescente M, de la Morena ME, Chan MV, Almarza E, Revilla N, Bohdan N, Miñano A et al. ( 2021 ) . A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant-negative effect on platelet function and bleeding diathesis . American Journal of Hematology vol. 96 , ( 3 ) E83 - E88 .
Mitchell JA, Kirkby NS, Ahmetaj-Shala B, Armstrong PC, Crescente M, Ferreira P, Lopes Pires ME, Vaja R et al. ( 2021 ) . Cyclooxygenases and the cardiovascular system . Pharmacology and Therapeutics vol. 217 ,
Crescente M, Armstrong PC, Kirkby NS, Edin ML, Chan MV, Lih FB, Jiao J, Maffucci T et al. ( 2020 ) . Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin . The FASEB Journal
Vulliamy P, Montague SJ, Gillespie S, Chan MV, Coupland LA, Andrews RK, Warner TD, Gardiner EE et al. ( 2020 ) . Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients . Blood Advances vol. 4 , ( 12 ) 2623 - 2630 .
Armstrong P, Ferreira PM, Chan M, Lundberg Slingsby M, Crescente M, Shih C, Kirkby N, Hobbs A et al. ( 2020 ) . Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy . Journal of Thrombosis and Haemostasis
Chan MV, Chen M-H, Barwari T, Huffman JE, Armstrong PC, Hwang S-J, Santer P, Wierer B et al. ( 2020 ) . Platelet Reactivity in Individuals Over 65 Years Old Is not Modulated by Age . Circulation Research
Chan MV, Hayman MA, Sivapalaratnam S, Crescente M, Allan HE, Edin ML, Zeldin DC, Milne GL et al. ( 2020 ) . Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function . Haematologica
Paterson GG, Young JM, Willson JA, Graham CJ, Dru RC, Lee EW, Torpey GS, Walmsley SR et al. ( 2020 ) . Hypoxia Modulates Platelet Purinergic Signalling Pathways . Thrombosis and Haemostasis vol. 120 , ( 2 ) 253 - 261 .
Palma-Barqueros V, Chan M, Crescente M, Bastida JM, Almarza E, Suarez Varela S, Mesa-Núñez C, Casas-Avilés I et al. ( 2019 ) . A New Molecular Variant in the PTGS1 Gene That Abrogates Generation of Thromboxane A2 Synthesis and Associates with Platelet Dysfunction and Bleeding . Blood . vol. 134 , 2375 - 2375 .
Mitchell JA, Shala F, Elghazouli Y, Warner TD, Gaston-Massuet C, Crescente M, Armstrong PC, Herschman HR et al. ( 2019 ) . Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox . Circulation Research vol. 125 , ( 9 ) 847 - 854 .
Vulliamy P, Gillespie S, Armstrong P, Allan H, Warner T, Brohi K ( 2019 ) . Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage . Proceedings of the National Academy of Sciences
Houde M, Carrier É, Grandbois M, Bkaily G, Warner TD, Korporaal SJA, Van Eck M, D'Orléans-Juste P ( 2019 ) . Altered Inhibition Of Platelet Aggregation In Hypercholerolemia In Mice And Humans . Atherosclerosis . vol. 287 , e109 - e110 .
Patel D, Warner TD, Armstrong PC ( 2019 ) . ICAM-1 contributes to the preferential binding of platelets to classical and intermediate monocyte subsets over neutrophils . BRITISH JOURNAL OF PHARMACOLOGY . Conference: Pharmacology 2018 from: 20/12/2018 to: 18/12/2018 , vol. 176 , 3038 - 3039 .
Mazi SI, Ahmetaj-Shala B, Warner TD, Mitchell JA, Kirkby NS ( 2019 ) . Omic profiling in healthy volunteers taking celecoxib reveals novel biomarkers regulated by cyclooxygenase-2 . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 85 , 1628 - 1628 .
Lucotti S, Cerutti C, Soyer M, Gil-Bernabé AM, Gomes AL, Allen PD, Smart S, Markelc B et al. ( 2019 ) . Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/ thromboxane A<inf>2</inf> . Journal of Clinical Investigation vol. 129 , ( 5 ) 1845 - 1862 .
Menke L, Marcone S, Allan H, Godson C, Warner T ( 2019 ) . Dihomo-gamma-linolenic acid alters the proteomic releasate profile and reduces platelet reactivity . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . vol. 49 , 132 - 132 .
Crescente M, Menke L, Chan MV, Armstrong PC, Warner TD ( 2019 ) . Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond) . British Journal of Pharmacology vol. 176 , ( 8 ) 988 - 999 .
Allan HE, Ferreira PMF, Crescente M, Warner TD ( 2019 ) . Platelet Activation Causes Vesicle Release and Loss of Mitochondria . CARDIOVASCULAR DRUGS AND THERAPY . vol. 33 , 268 - 268 .
Sivapalaratnam S, Melissa H, Lentaigne C, Chan M, Crescente M, Allan H, Wedderburn K, Hanif M et al. ( 2018 ) . Congenital Aspirin-like Defect As a Result of Autosomal Recessive Variants in PTGS1 . Blood . vol. 132 , 1156 - 1156 .
Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M et al. ( 2018 ) . Inhibition of profibrotic microRNA-21 affects platelets and their releasate . JCI insight vol. 3 , ( 21 )
Warner T, Halford G, Watson S ( 2018 ) . In celebration of Professor Gus Born's life, 29 July 1921 - 16 April 2018 . Platelets vol. 29 , ( 8 ) 743 - 743 .
Knowles RB, Warner TD ( 2018 ) . Anti-platelet drugs and their necessary interaction with endothelial mediators and platelet cyclic nucleotides for therapeutic efficacy . Pharmacol Ther vol. 193 , 83 - 90 .
Barwari T, Eminaga S, Lu R, Armstrong PC, Schulte C, Lynch M, Chan MV, Barallobre-Barreiro J et al. ( 2018 ) . Abstract 300: MicroRNA-21 Affects Platelets and Their Releasate: A Novel Mechanism for the Anti-Fibrotic Effects of MicroRNA-21 Inhibition . Circulation Research . vol. 123 ,
Lucotti S, Cerutti C, Soyer M, Gil-Bernabé AM, Gomes AL, Allen PD, Smart S, Markelc B et al. ( 2018 ) . Abstract 4196: Aspirin inhibits metastasis in the intravascular phase through the blockade of COX-1-TXA 2 pathway in platelets . 4196 - 4196 .
Barwari T, Eminaga S, Armstrong P, Chan M, Lu R, Barallobre-Barreiro J, Yin X, Pechlaner R et al. ( 2018 ) . 82 Microrna-21 regulates transforming growth factor beta-1 release from platelets . Heart . vol. 104 ,
Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H et al. ( 2018 ) . Letter by Mitchell et al Regarding Article, "Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment" . Circulation research vol. 122 , ( 10 ) e84 - e85 .
Chan MV, Leadbeater PD, Watson SP, Warner TD ( 2018 ) . Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry . Platelets1 - 4 .
Chan MV, Armstrong PC, Warner TD ( 2018 ) . 96-well plate-based aggregometry . Platelets1 - 6 .
Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H et al. ( 2018 ) . Kidney transplantation in a patient lacking cytosolic phospholipase A<inf>2</inf> proves renal origins of urinary PGI-M and TX-M . Circulation Research vol. 122 , ( 4 ) 555 - 559 .
Lundberg Slingsby MH, Gliemann L, Thrane M, Rytter N, Egelund J, CHAN MV, Armstrong PC, Warner TD et al. ( 2018 ) . Platelet responses to pharmacological and physiological interventions in middle-aged men with different habitual physical activity levels . Acta Physiol (Oxf)
Allan HE, Crescente M, Warner TD ( 2018 ) . Investigating the behaviour of mitochondria following platelet activation . Proceedings for Annual Meeting of The Japanese Pharmacological Society . vol. WCP2018 ,
Chan MV, Barwari T, Huffman D, Armstrong PC, Santer P, Kiechl S, Willeit J, Mayr M et al. ( 2018 ) . Platelet reactivity in an elderly and healthy population . Proceedings for Annual Meeting of The Japanese Pharmacological Society . vol. WCP2018 , or25 - or22 .
Crescente M, Armstrong PC, Chan MV, Edin ML, Maffucci T, Kirkby NS, Mitchell JA, Zeldin DC et al. ( 2018 ) . Understanding the cardiovascular effects of low dose aspirin by using a platelet COX-1-/- mouse model . Proceedings for Annual Meeting of The Japanese Pharmacological Society . vol. WCP2018 ,
VULLIAMY P, GILLESPIE S, ARMSTRONG P, CHAN M, DAVENPORT R, WARNER T, BROHI K ( 2017 ) . Platelets Shift Towards a Procoagulant and Proin ammatory Phenotype at the Expense of Aggregation During Trauma Hemorrhage: a Potential Role of Extracellular Histones . Circulation . Conference: American Heart Association Scientific Sessions ( Anaheim, CA ) from: 11/11/2017 to: 15/11/2017 , vol. e448-467 ,
Vulliamy P, Gillespie S, Armstrong PC, Chan MV, Davenport RA, Warner TD, Brohi K ( 2017 ) . Platelets Shift Towards a Procoagulant and Proinflammatory Phenotype at the Expense of Aggregation During Trauma Hemorrhage: a Potential Role of Extracellular Histones . CIRCULATION . vol. 136 , E464 - E464 .
Barwari T, Eminaga S, Armstrong PC, Chan MV, Lu R, Barallobre-Barreiro J, Yin X, Pechlaner R et al. ( 2017 ) . MicroRNA-21 Regulates Transforming Growth Factor Beta-1 Release From Platelets: A Novel Mechanism for the Anti-Fibrotic Effects of MicroRNA-21 Inhibition . CIRCULATION . vol. 136 ,
Mitchell JA, Shala F, Ahmetaj-Shala B, Jiao J, Armstrong PC, Chan MV, Crescente M, Warner TD et al. ( 2017 ) . Novel Tissue-specific Cyclooxygenase-1 Knockout Mice Demonstrate a Dominant Role for Endothelial Cyclooxygenase-1 in Prostacyclin Production . CIRCULATION . vol. 136 ,
Scagliotti V, Gutierrez LP, Gualtieri A, Jimenez F, Kirkby N, Mitchell J, Warner T, Gevers E et al. ( 2017 ) . Cyclooxygenase-2 is a potential target for the treatment of Adamantinomatous craniopharyngioma . Endocrine Abstracts .
Carrier É, Houde M, Grandbois M, Bkaily G, Warner TD, D'Orléans-Juste P ( 2017 ) . Inhibition of platelet aggregation ex vivo is repressed in apolipoprotein E deficient mice . Can J Physiol Pharmacol vol. 95 , ( 8 ) 954 - 960 .
Unsworth AJ, Bye AP, Tannetta DS, Desborough MJR, Kriek N, Sage T, Allan HE, Crescente M et al. ( 2017 ) . Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets . Arterioscler Thromb Vasc Biol vol. 37 , ( 8 ) 1482 - 1493 .
Crescente M, Armstrong PC, CHAN MV, Edin ML, Lih FB, Jiao J, Gaston-Massuet C, Cottrell GS et al. ( 2017 ) . PLATELET COX-1 KNOCKOUT MOUSE AS A MODEL OF THE EFFECTS OF ASPIRIN IN THE CARDIOVASCULAR SYSTEM . HEART . Conference: BCS Annual Conference, ‘Cardiology at the Extremes' vol. 103 , A108 - A109 .
Knowles RB, Lawrence MJ, Ferreira PM, Hayman MA, D'Silva LA, Stanford SN, Sabra A, Tucker AT et al. ( 2017 ) . Platelet reactivity influences clot structure as assessed by fractal analysis of viscoelastic properties . Platelets1 - 9 .
Hayman M, Armstrong P, Chan M, Warner T ( 2017 ) . Functional Analyses of Reticulated Platelets . FASEB JOURNAL . vol. 31 ,
Ahmetaj-Shala B, Tesfai A, Constantinou C, Leszczynski R, Chan MV, Gashaw H, Galaris G, Mazi S et al. ( 2017 ) . Pharmacological assessment of ibuprofen arginate on platelet aggregation and colon cancer cell killing . Biochemical and Biophysical Research Communications vol. 484 , ( 4 ) 762 - 766 .
ARMSTRONG PCJ, hoefer T, knowles RB, Tucker AT, Hayman MA, Ferreira PM, Chan MV, Warner TD ( 2017 ) . Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies . Arteriosclerosis, Thrombosis, and Vascular Biology
Watson SP, Daly ME, Harrison P, Lowe GC, Paterson A, Rivera J, Warner TD, Morgan NV ( 2016 ) . ISTH Advanced Training Course on platelet bleeding disorders: How should they be investigated?: St. Anne’s College, Oxford, 6–9<sup>th</sup> September 2016 . Platelets vol. 27 , ( 8 ) 719 - 721 .
Mitchell JA, Knowles R, Kirkby NS, Reed DM, White W, Edin ML, Longhurst H, Yaqoob M et al. ( 2016 ) . Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A(2) Leads to Urinary Prostacyclin and Thromboxane A(2) Metabolites Within Normal Ranges . CIRCULATION . vol. 134 ,
Rauzi F, Kirkby NS, Edin ML, Whiteford J, Zeldin DC, Mitchell JA, Warner TD ( 2016 ) . Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1 . The FASEB Journal
Ferreira P, Armstrong P, Chan M, Warner T ( 2016 ) . 169 Soluble Guanylate Cyclase Activators as Combination Anti-Platelet Therapy with P2Y12 Inhibitors and PDE Inhibitors: In vivo and Ex vivo Studies . Heart . vol. 102 ,
Knowles R, D¿Silva L, Armstrong P, Chan M, Lawrence M, Standford S, Sabre A, Tucker A et al. ( 2016 ) . 186 Platelets as Key Regulators of Fibrin-Clot Architecture as Assessed by Fractal Analysis of Viscoelastic Properties; Effects of Standard Anti-Platelet Therapies . Heart . vol. 102 ,
Hinz C, Aldrovandi M, Uhlson C, Marnett LJ, Longhurst HJ, Warner TD, Alam S, Slatter DA et al. ( 2016 ) . Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid . Journal of Biological Chemistry Article jbc.M115.700609 ,
Knowles R, D¿Silva L, Stanford S, Armstrong P, Chan M, Tucker A, Ferreira P, Sabra A et al. ( 2016 ) . INSIGHTS INTO THE ROLE OF PLATELETS IN FIBRIN CLOT FORMATION AND THE EFFICACY OF ANTI-PLATELET THERAPIES . Journal of the American College of Cardiology . vol. 67 ,
Chan MV, Knowles RBM, Lundberg MH, Tucker AT, Mohamed NA, Kirkby NS, Armstrong PCJ, Mitchell JA et al. ( 2016 ) . P2Y<inf>12</inf> receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation . British Journal of Clinical Pharmacology vol. 81 , ( 4 ) 621 - 633 .
Warner TD, Armstrong PC, Chan MV, Knowles RB ( 2016 ) . The importance of endothelium-derived mediators to the efficacy of dual anti-platelet therapy . Expert Review of Hematology vol. 9 , ( 3 ) 223 - 225 .
Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K et al. ( 2016 ) . Association of MicroRNAs and YRNAs with platelet function . Circulation Research vol. 118 , ( 3 ) 420 - 432 .
Kirkby NS, Reed DM, Edin ML, Rauzi F, Mataragka S, Vojnovic I, Bishop-Bailey D, Milne GL et al. ( 2015 ) . Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation . FASEB J vol. 29 , ( 11 ) 4568 - 4578 .
Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie LS et al. ( 2015 ) . Reply to letter regarding article, "evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: Novel explanation of cardiovascular side effects associated with anti-inflammatory drugs" . Circulation vol. 132 , ( 17 ) e213 - e214 .
Khanna V, Armstrong PCJ, Warner TD, Curzen N ( 2015 ) . Prostaglandin E1 potentiates the effects of P2Y12 blockade on ADP-mediated platelet aggregation in vitro: Insights using short thromboelastography . Platelets vol. 26 , ( 7 ) 689 - 692 .
Armstrong PCJ, Kirkby NS, Chan MV, Finsterbusch M, Hogg N, Nourshargh S, Warner TD ( 2015 ) . Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction . Blood vol. 126 , ( 10 ) e11 - e18 .
Knowles R, Chan M, Hayman M, Armstrong P, Tucker A, Timmis A, Warner T ( 2015 ) . 158 The Anti-Platelet Effectiveness of P2Y12 Receptor Blockade is Strongly Influenced by the Endothelium-Derived Mediators Nitric Oxide and Prostacyclin . Heart vol. 101 , ( Suppl 4 )
Knowles R, Chan M, Lundberg M, Kirkby N, Shih C-C, Armstrong P, Hayman M, Vojnovic I et al. ( 2015 ) . 213 Synergy between Endothelial Mediators and P2Y12 Receptor Blockade as a Potential Determinant in Tailoring Anti-Platelet Therapy . Heart . vol. 101 ,
Rauzi F, Kirkby N, Edin M, Zeldin D, Whiteford J, Mitchell J, Warner T ( 2015 ) . 15(S)-HETE is a pro-angiogenic factor produced by platelets through COX-1 . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 13 , 225 - 225 .
Armstrong PC, Warner TD ( 2015 ) . Characterising cell-type interactions following platelet activation in a novel low volume whole blood assay . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 13 , 657 - 657 .
Knowles R, Chan M, Hayman M, Armstrong P, Tucker A, Timmis A, Warner T ( 2015 ) . THE ANTI-PLATELET EFFECTIVENESS OF P2Y12 RECEPTOR BLOCKADE IS STRONGLY INFLUENCED BY THE ENDOTHELIUM- DERIVED MEDIATORS NITRIC OXIDE AND PROSTACYCLIN . HEART . vol. 101 , A90 - A91 .
Knowles RB, Chan MV, Armstrong PC, Shih C-C, Hayman MA, Vojnovic I, Tucker AT, Timmis AD et al. ( 2015 ) . The effectiveness of P2Y12 receptor blockade is strongly determined by the presence of endothelial Mediators prostacyclin and nitric oxide . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 13 , 784 - 784 .
Rull G, Mohd-Zain Z, Shiel J, Lundberg MH, Collier DJ, Johnston A, Warner TD, Corder R ( 2015 ) . Effects of High Flavanol Dark Chocolate on Cardiovascular Function and Platelet Aggregation . Vascular pharmacology
Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie L et al. ( 2015 ) . Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs . CIRCULATION vol. 131 , ( 7 ) 633 - U113 .
Hoefer T, Armstrong PC, Finsterbusch M, Chan MV, Kirkby NS, Warner TD ( 2015 ) . Drug-free platelets can act as seeds for aggregate formation during antiplatelet therapy . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 35 , ( 10 ) 2122 - 2133 .
Floyd CN, Ferro A, Warner TD ( 2015 ) . Expression of the PlA2 allele of glycoprotein IIIa and its impact on platelet function . JRSM Cardiovasc Dis vol. 4 ,
Ross CL, Galloway-Phillipps N, Armstrong PC, Mitchell JA, Warner TD, Brearley C, Ito M, Tunstall T et al. ( 2015 ) . Protocol for a human in vivo model of acute cigarette smoke inhalation challenge in smokers with COPD: Monitoring the nasal and systemic immune response using a network biology approach . BMJ Open vol. 5 , ( 1 )
Bender L, Mayr M, Kaudewitz D, Skroblin P, Willeit P, Morton A, Gracio F, Dudek K et al. ( 2014 ) . Plasma microRNA levels in patients with acute coronary syndrome are associated with platelet function . Atherosclerosis . vol. 237 ,
Knowles RB, Chan MV, Armstrong PC, Shih C-C, Hayman MA, Vojnovic I, Tucker AT, Timmis AD et al. ( 2014 ) . The Effectiveness of P2Y12 Receptor Antagonist Therapy is Strongly Determined by Endothelial Mediators of Platelet Function . CIRCULATION . vol. 130 ,
Lordkipanidze M, Lowe GC, Kirkby NS, Chan MV, Lundberg MH, Morgan NV, Bem D, Nisar SP et al. ( 2014 ) . Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay . BLOOD vol. 123 , ( 8 ) E11 - E22 .
Kirkby NS, Lundberg MH, Wright WR, Warner TD, Paul-Clark MJ, Mitchell JA ( 2014 ) . COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks . PLoS One vol. 9 , ( 6 )
Brooke MA, Longhurst HJ, Plagnol V, Kirkby NS, Mitchell JA, Rüschendorf F, Warner TD, Kelsell DP et al. ( 2014 ) . Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α . Gut vol. 63 , ( 1 ) 96 - 104 .
Lordkipanidze M, Chan MV, Lowe GC, Dawood BB, Warner TD, Watson SP, Grp UKGAPPS ( 2013 ) . Head-to-head comparison of the optimul assay (96-well plate aggregometry) with gold standard light transmission aggregometry for detection of acquired and inherited platelet defects . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 11 , 43 - 44 .
Kirkhy NS, Wright WR, Warner TD, Paul-Clark MJ, Mitchell JA ( 2013 ) . COX-2 and Cardiovascular Risk; Identification of New COX-2 Targets and Pathways Outside the Vessel Wall . CIRCULATION . vol. 128 ,
Ahmetaj-Shala B, Kirkby NS, Al-yamani M, Warner TD, Leiper J, Mitchell JA ( 2013 ) . Evidence That Links Cyclo-oxygenase-2 Inhibition With Increased Asymmetric Dimethylarginine: Novel Explanation of Cardiovascular Side Effects Associated With Anti-inflammatory Drugs . CIRCULATION . vol. 128 ,
Kaudewitz D, Lee R, Willeit P, Zampetaki A, Morton AC, Warner TD, Storey RF, Channon K et al. ( 2013 ) . Impact of Medication on Quantification of Plasma MicroRNAs in Patients With Cardiovascular Disease . CIRCULATION . vol. 128 ,
Kirkby NS, Chan MV, Lundberg MH, Massey KA, Edmands WMB, Mackenzie LS, Holmes E, Nicolaou A et al. ( 2013 ) . Aspirin-triggered 15-epi-lipoxin A<inf>4</inf> predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: Implications for a clinical test . FASEB Journal vol. 27 , ( 10 ) 3938 - 3946 .
Kirkby NS, Lundberg MH, Chan MV, Vojnovic I, Solomon AB, Emerson M, Mitchell JA, Warner TD ( 2013 ) . Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide . Proc Natl Acad Sci U S A vol. 110 , ( 39 ) 15782 - 15787 .
Bianca RDDV, Mitidieri E, Di Minno MND, Kirkby NS, Warner TD, Di Minno G, Cirino G, Sorrentino R ( 2013 ) . Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia . PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA vol. 110 , ( 39 ) 15812 - 15817 .
Bianca RDEDV, Mitidieri E, Di Minno MND, Kirkby NS, Warner TD, Di Minno G, Cirino G, Sorrentino R ( 2013 ) . The hydrogen sulfide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia . NITRIC OXIDE-BIOLOGY AND CHEMISTRY . vol. 31 , S24 - S25 .
Kirkby NS, Zaiss AK, Wright WR, Jiao J, Chan MV, Warner TD, Herschman HR, Mitchell JA ( 2013 ) . Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies . Biochem Biophys Res Commun vol. 438 , ( 2 ) 249 - 256 .
Floyd CN, Warner TD, Ferro A ( 2013 ) . Comparison of the optimul assay with light transmission aggregometry for the detection of aspirin resistance in patients with stable coronary artery disease . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 11 , 643 - 643 .
Willeit P, Zampetaki A, Kaudewitz D, Lee R, Dudek K, King A, Kirkby NS, Markus HS et al. ( 2013 ) . 265 PLASMA MICRORNAS AS BIOMARKERS FOR PLATELET INHIBITION . Heart . vol. 99 ,
Hoefer T, Warner TD ( 2013 ) . DURING ANTI-PLATELET THERAPY PLATELET TURNOVER MAY LEAD TO THE EMERGENCE OF A MINORITY OF UNINHIBITED PLATELETS SUFFICIENT TO INITIATE AND DRIVE PLATELET AGGREGATE FORMATION . HEART . vol. 99 ,
Lundberg MH, Kirkby NS, Mitchell JA, Warner TD ( 2013 ) . P2Y12 INHIBITION GREATLY POTENTIATES THE ANTI-PLATELET EFFECTS OF PROSTACYCLIN AND NITRIC OXIDE . HEART . vol. 99 , A137 - U630 .
Rauzi F, Kirkby NS, Edin M, Mitchell JA, Zeldin D, Warner TD ( 2013 ) . PLATELET COX-1 SUPPORTS THE PRODUCTION OF BOTH PROSTANOIDS AND HETES . HEART . vol. 99 , A114 - A114 .
Kirkby NS, Zaiss AK, Urquhart P, Jiao J, Austin PJ, Warner TD, Nicolaou A, Herschman HR et al. ( 2013 ) . Cox2 reporter gene expression and prostacylin mass spectrometry confirm vascular COX-1 dominance for prostacyclin production . FASEB JOURNAL . vol. 27 ,
Bjorkman J-A, Zachrisson H, Forsberg G-B, von Bahr H, Hansson GI, Warner TD, Nylander S ( 2013 ) . High-dose aspirin in dogs increases vascular resistance with limited additional anti-platelet effect when combined with potent P2Y(12) inhibition . THROMBOSIS RESEARCH vol. 131 , ( 4 ) 313 - 319 .
Willeit P, Zampetaki A, Dudek K, Kaudewitz D, King A, Kirkby NS, Crosby-Nwaobi R, Prokopi M et al. ( 2013 ) . Circulating MicroRNAs as Novel Biomarkers for Platelet Activation . CIRCULATION RESEARCH vol. 112 , ( 4 ) 595 - + .
Mitchell JA, Warner TD ( 2013 ) . Reply to Ricciotti et al.: Evidence for vascular COX isoforms . PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA vol. 110 , ( 3 ) E184 - E184 .
( 2013 ) . Correction for Kirkby et al., Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system . Proceedings of the National Academy of Sciences of the United States of America vol. 110 , ( 4 ) 1561 - 1561 .
Kirkby NS, Zaiss AK, Urquhart P, Jiao J, Austin PJ, Al-Yamani M, Lundberg MH, MacKenzie LS et al. ( 2013 ) . LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression . PLoS One vol. 8 , ( 7 )
Kirkby NS, Lundberg MH, Harrington LS, Leadbeater PDM, Milne GL, Potter CMF, Al-Yamani M, Adeyemi O et al. ( 2012 ) . Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system . PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA vol. 109 , ( 43 ) 17597 - 17602 .
Mitidieri E, Bianca RDDV, Kirkby N, Warner TD, Cirino G, Sorrentino R ( 2012 ) . L-Cysteine/H2S pathway involvement in human platelet aggregation . NITRIC OXIDE-BIOLOGY AND CHEMISTRY . vol. 27 , S31 - S32 .
Warner TD, Paul-Clark M, Mitchell JA ( 2012 ) . Smoking, atherothrombosis and clopidogrel . Heart vol. 98 , ( 13 ) 963 - 964 .
Warner TD, Mitchell JA, Kirkby NS ( 2012 ) . Short thromboelastography and the identification of high platelet reactivity while on and off therapy . Heart vol. 98 , ( 9 ) 679 - 680 .
Swales KE, Moore R, Truss NJ, Tucker A, Warner TD, Negishi M, Bishop-Bailey D ( 2012 ) . Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress . Cardiovasc Res vol. 93 , ( 4 ) 674 - 681 .
Mcloughlin TF, Chan MV, Warner TD, Hart DP ( 2012 ) . Validation of a novel, high-throughput platelet aggregation technique . HAEMOPHILIA . vol. 18 , 18 - 19 .
Andersson T, Morrison D, Nagy P, Pisupati J, Schettler J, Warner TD ( 2012 ) . Evaluation of the Pharmacodynamics of Acetylsalicylic Acid 81 mg With or Without Esomeprazole 20 mg in Healthy Volunteers . AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS vol. 12 , ( 4 ) 217 - 224 .
Chan MV, Warner TD ( 2012 ) . Standardised optical multichannel (optimul) platelet aggregometry using high-speed shaking and fixed time point readings . Platelets vol. 23 , ( 5 ) 404 - 408 .
Sambu N, Dent H, Warner T, Englyst N, Leadbeater P, Hobson A, Calver A, Corbett S et al. ( 2011 ) . Stopping Clopidogrel 1 year After Drug-Eluting Stent (DES) Implantation: Is It Safe? . JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY . vol. 58 , B41 - B41 .
Truss NJ, Warner TD ( 2011 ) . Gasotransmitters and platelets . Pharmacol Ther vol. 132 , ( 2 ) 196 - 203 .
Warner TD, Nylander S, Whatling C ( 2011 ) . Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy . Br J Clin Pharmacol vol. 72 , ( 4 ) 619 - 633 .
Kirkby NS, Leadbeater PDM, Chan MV, Nylander S, Mitchell JA, Warner TD ( 2011 ) . Antiplatelet effects of aspirin vary with level of P2Y₁₂ receptor blockade supplied by either ticagrelor or prasugrel . J Thromb Haemost vol. 9 , ( 10 ) 2103 - 2105 .
Leadbeater PDM, Kirkby NS, Thomas S, Dhanji A-R, Tucker AT, Milne GL, Mitchell JA, Warner TD ( 2011 ) . Aspirin has little additional anti-platelet effect in healthy volunteers receiving prasugrel . J Thromb Haemost vol. 9 , ( 10 ) 2050 - 2056 .
Sambu N, Dent H, Englyst N, Warner TD, Leadbeater P, Roderick P, Gray H, Simpson I et al. ( 2011 ) . Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study . HEART vol. 97 , ( 20 ) 1661 - 1667 .
Kirkby NS, Leadbeater PDM, Chan MV, Nylander S, Mitchell JA, Warner TD ( 2011 ) . Aspirin augments the anti-platelet effects of partial but not complete P2Y(12) receptor blockade by ticagrelor . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 9 , 780 - 780 .
Kirkby NS, Singhal R, Mitchell JA, Warner TD ( 2011 ) . Synergistic inhibition of platelet aggregation by nitric oxide and prostacyclin is potentiated by P2Y(12) blockade . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 9 , 780 - 781 .
Leadbeater PDM, Mitchell JA, Warner TD ( 2011 ) . The effect of stir-speed and time on TP-receptor induced platelet aggregation in the presence of aspirin and P2Y(12) receptor blockade . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 9 , 779 - 780 .
Leadbeater PDM, Farndale RW, Mitchell JA, Warner TD ( 2011 ) . The effect of stir-speed on GPVI-dependent platelet aggregation . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 9 , 528 - 529 .
Leadbeater PDM, Mitchell JA, Warner TD ( 2011 ) . The effect of time on platelet aggregation assessed by light transmission . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 9 , 779 - 779 .
Kirkby NS, Harrington LS, Lundberg MH, Hoefer T, Warner TD, Mitchell JA ( 2011 ) . CONTRIBUTION OF COX1 AND COX2 TO PROSTACYCLIN RELEASE BY HEALTHY MOUSE TISSUES . INFLAMMATION RESEARCH . vol. 60 , 116 - 117 .
Wright WR, Kirkby NS, Harrington LS, Lundberg MH, Paul-Clark MJ, Warner TD, Mitchell JA ( 2011 ) . ROLE OF COX-1 AND COX-2 IN THE RELEASE OF PROSTANOIDS IN MURINE LUNG AND ISOLATED LUNG FIBROBLASTS . INFLAMMATION RESEARCH . vol. 60 , 232 - 232 .
Sambu N, Dent H, Warner T, Englyst N, Leadbeater P, Hobson A, Calver A, Corbett S et al. ( 2011 ) . WHAT HAPPENS TO PLATELET FUNCTION AND VASCULAR INFLAMMATION WHEN CLOPIDOGREL IS WITHDRAWN? INSIGHTS USING SHORT THROMBELASTOGRAPHY . HEART . vol. 97 , A16 - A16 .
Armstrong PCJ, Leadbeater PD, Chan MV, Kirkby NS, Jakubowski JA, Mitchell JA, Warner TD ( 2011 ) . In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation . J Thromb Haemost vol. 9 , ( 3 ) 552 - 561 .
Sambu N, Warner T, Curzen N ( 2011 ) . Clopidogrel withdrawal: Is there a "rebound" phenomenon? . THROMB HAEMOSTASIS vol. 105 , ( 2 ) 211 - 220 .
Potter CMF, Lundberg MH, Harrington LS, Warboys CM, Warner TD, Berson RE, Moshkov AV, Gorelik J et al. ( 2011 ) . Role of Shear Stress in Endothelial Cell Morphology and Expression of Cyclooxygenase Isoforms . ARTERIOSCL THROM VAS vol. 31 , ( 2 ) 384 - U314 .
Warner TD ( 2011 ) . What is the best dose of aspirin in association with P2Y12 antagonists? reply . HEART vol. 97 , ( 3 ) 264 - 264 .
Huang RY, Li MY, Hsin MKY, Underwood MJ, Ma LT, Mok TSK, Warner TD, Chen GG ( 2011 ) . 4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A(2) and its receptor . ONCOGENE vol. 30 , ( 1 ) 106 - 116 .
Bystrom J, Wray JA, Sugden MC, Holness MJ, Swales KE, Warner TD, Edin ML, Zeldin DC et al. ( 2011 ) . Endogenous epoxygenases are modulators of monocyte/macrophage activity . PLoS One vol. 6 , ( 10 )
Chan MV, Armstrong PCJ, Papalia F, Kirkby NS, Warner TD ( 2011 ) . Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing . Platelets vol. 22 , ( 7 ) 485 - 494 .
Armstrong PC, Kirkby NS, Zain ZN, Emerson M, Mitchell JA, Warner TD ( 2011 ) . Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse . PLoS One vol. 6 , ( 5 )
Warner TD, Bjorkman J-A, Zachrisson H, Nylander S ( 2010 ) . Acetylsalicylic Acid (ASA) Adds Limited Additional Antiplatelet Effect When Given in Addition to High-Level P2y(12) Receptor Inhibition and Can Increase Peripheral Vascular Resistance . CIRCULATION . vol. 122 ,
Kolstoe SE, Mangione PP, Bellotti V, Taylor GW, Tennent GA, Deroo S, Morrison AJ, Cobb AJA et al. ( 2010 ) . Trapping of palindromic ligands within native transthyretin prevents amyloid formation . P NATL ACAD SCI USA vol. 107 , ( 47 ) 20483 - 20488 .
Warner TD, Armstrong PCJ, Curzen NP, Mitchell JA ( 2010 ) . Dual antiplatelet therapy in cardiovascular disease: does aspirin increase clinical risk in the presence of potent P2Y12 receptor antagonists? . Heart vol. 96 , ( 21 ) 1693 - 1694 .
Moreno L, McMaster SK, Gatheral T, Bailey LK, Harrington LS, Cartwright N, Armstrong PCJ, Warner TD et al. ( 2010 ) . Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages . BRIT J PHARMACOL vol. 160 , ( 8 ) 1997 - 2007 .
Leadbeater P, Pathan N, Paul-Clark M, Warner T, Mitchell J ( 2010 ) . Serum lipoteichoic acid in paediatric patients undergoing surgery with cardiopulmonary bypass . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 70 , 293 - 293 .
Shinhmar S, Truss N, Armstrong P, Vojnovic I, Warner T ( 2010 ) . Use of a 96-well plate method for the determination of the anti-platelet effectiveness of a novel NO releasing aspirin molecule . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 70 , 303 - 303 .
Armstrong PCJ, Dhanji A-RA, Tucker AT, Mitchell JA, Warner TD ( 2010 ) . Reduction of platelet thromboxane A2 production ex vivo and in vivo by clopidogrel therapy . J Thromb Haemost vol. 8 , ( 3 ) 613 - 615 .
Vessillier S, Duchene J, Vojnovic I, Cipollone F, Mezzetti A, White S, Ahluwalia A, Bishop-Bailey D et al. ( 2009 ) . THERAPEUTIC TARGETTING OF ATHEROSCLEROTIC PLAQUES WITH LATENT INTERLEUKIN-4 . HEART . vol. 95 ,
Armstrong PCJ, Dhanji AA, Tucker AT, Mitchell JA, Warner TD ( 2009 ) . URINARY 11-DEHYDRO-THROMBOXANE B2 AS A MARKER OF THE ANTI-PLATELET EFFECTS OF CLOPIDOGREL OR ASPIRIN THERAPY IN HEALTHY MALE VOLUNTEERS . HEART . vol. 95 ,
Truss NJ, Armstrong PCJ, Liverani E, Vojnovic I, Warner TD ( 2009 ) . Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periods . J Thromb Haemost vol. 7 , ( 11 ) 1897 - 1905 .
Ali FY, Hall MG, Desvergne B, Warner TD, Mitchell JA ( 2009 ) . PPARbeta/delta agonists modulate platelet function via a mechanism involving PPAR receptors and specific association/repression of PKCalpha--brief report . Arterioscler Thromb Vasc Biol vol. 29 , ( 11 ) 1871 - 1873 .
Leung KC, Hsin MKY, Chan JSY, Yip JHY, Li MY, Leung BCS, Mok TSK, Warner TD et al. ( 2009 ) . Inhibition of thromboxane synthase induces lung cancer cell death via increasing the nuclear p27 . EXP CELL RES vol. 315 , ( 17 ) 2974 - 2981 .
Wray JA, Sugden MC, Zeldin DC, Greenwood GK, Samsuddin S, Miller-Degraff L, Bradbury JA, Holness MJ et al. ( 2009 ) . The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo . PLoS One vol. 4 , ( 10 )
Armstrong PCJ, Dhanji A-R, Truss NJ, Zain ZNM, Tucker AT, Mitchell JA, Warner TD ( 2009 ) . Utility of 96-well plate aggregometry and measurement of thrombi adhesion to determine aspirin and clopidogrel effectiveness . Thromb Haemost vol. 102 , ( 4 ) 772 - 778 .
Morris T, Stables M, Hobbs A, de Souza P, Colville-Nash P, Warner T, Newson J, Bellingan G et al. ( 2009 ) . Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans . J IMMUNOL vol. 183 , ( 3 ) 2089 - 2096 .
Truss NJ, Beavis J, Maccallum PK, Harrison P, Warner TD ( 2009 ) . Rapid and accurate method for the von Willebrand factor ristocetin cofactor assay using 96-well microtiter plates . J THROMB HAEMOST vol. 7 , ( 7 ) 1226 - 1228 .
Ali FY, Armstrong PCJ, Dhanji A-RA, Tucker AT, Paul-Clark MJ, Mitchell JA, Warner TD ( 2009 ) . Antiplatelet actions of statins and fibrates are mediated by PPARs . Arterioscler Thromb Vasc Biol vol. 29 , ( 5 ) 706 - 711 .
Armstrong PCJ, Truss NJ, Ali FY, Dhanji AA, Vojnovic I, Zain ZNM, Bishop-Bailey D, Paul-Clark MJ et al. ( 2008 ) . Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet production of thromboxane A2 . J Thromb Haemost vol. 6 , ( 11 ) 1933 - 1943 .
Harrington LS, Lucas R, McMaster SK, Moreno L, Scadding G, Warner TD, Mitchell JA ( 2008 ) . COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma . FASEB J vol. 22 , ( 11 ) 4005 - 4010 .
Ali FY, Warner TD, Mitchell JA ( 2008 ) . Comparison of responses in IP and PPAR beta deleted murine platelets . HEART . vol. 94 ,
Zain ZNM, Armstrong PCJ, Pearson NJ, Mitchell JA, Warner TD ( 2008 ) . Evaluation of aspirin inhibition of platelet aggregation induced by combination of collagen and adrenaline in a 96-well plate format . HEART . vol. 94 ,
Dhanji AA, Truss NJ, Bishop-Bailey D, Shipolini A, Mitchell JA, Warner TD ( 2008 ) . Generation of clonal populations of prostaglandin I-2-producing rat vascular smooth muscle cells: Potential utility for production of bypass vessels . HEART . vol. 94 ,
Armstrong PCJ, Zain ZNM, Truss NJ, Vojnovic I, Bishop-Bailey D, Mitchell JA, Warner TD ( 2008 ) . Linear relationship between platelet aggregation and thromboxane A(2) production . HEART . vol. 94 ,
Truss NJ, Armstrong PCJ, Zain ZN, Ali FY, Warner TD ( 2008 ) . Platelet aggregation after storage of whole blood at 4 degrees C . HEART . vol. 94 ,
Vessillier S, Duchene J, Vojnovic I, Ahluwalia A, Bishop-Bailey D, Chernajovsky Y, Warner TD ( 2008 ) . Stabilisation of atherosclerotic plaques: The latent targeting cytokines strategy . HEART . vol. 94 ,
Boesen EI, Sasser JM, Saleh MA, Potter WA, Woods M, Warner TD, Pollock JS, Pollock DM ( 2008 ) . Interleukin-1 beta, but not interleukin-6, enhances renal and systemic endothelin production in vivo . AM J PHYSIOL-RENAL vol. 295 , ( 2 ) F446 - F453 .
Papalia F, Armstrong PCJ, Pearson NJ, Zain ZNM, Ali FY, Vojnovic I, Warner TD ( 2008 ) . Development of a routine test of platelet reactivity . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 65 , 979 - 979 .
Aboud Z, Misra S, Warner T, Miall P, Benjamin N, Hobbs A, Webb A, Ahluwalia A ( 2008 ) . The enterosalivary bioconversion of nitrate to nitrite underlies the blood pressure (BP) lowering and anti-platelet effects of a dietary nitrate load . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 65 , 999 - 999 .
Warner TD, Mitchell JA ( 2008 ) . COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs . LANCET vol. 371 , ( 9608 ) 270 - 273 .
Truss NJ, Warner TD ( 2008 ) . Gases help fuel the vascular debate . EXP PHYSIOL vol. 93 , ( 1 ) 139 - 140 .
Li YTY, Swales KE, Thomas GJ, Warner TD, Bishop-Bailey D ( 2007 ) . Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration . Arterioscler Thromb Vasc Biol vol. 27 , ( 12 ) 2606 - 2611 .
Patel TA, Belcher E, Warner TD, Harding SE, Mitchell JA ( 2007 ) . Identification and characterization of a dysfunctional cardiac myocyte phenotype: Role of bacteria, toll-like receptors, and endothelin . SHOCK vol. 28 , ( 4 ) 434 - 440 .
Piqueras L, Norlyng L, Perretti M, Li Y, Sanz MJ, Real JT, Warner T, Bishop-Bayley D ( 2007 ) . PPARb inhibits neutrophil-endothelium interactions under flow . INFLAMM RES . vol. 56 , S453 - S454 .
Moraes LA, Swales KE, Wray JA, Damazo A, Gibbins JM, Warner TD, Bishop-Bailey D ( 2007 ) . Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets . Blood vol. 109 , ( 9 ) 3741 - 3744 .
Piqueras L, Reynolds AR, Hodivala-Dilke KM, Alfranca A, Redondo JM, Hatae T, Tanabe T, Warner TD et al. ( 2007 ) . Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis . Arterioscler Thromb Vasc Biol vol. 27 , ( 1 ) 63 - 69 .
Mitchell JA, Lucas R, Vojnovic I, Hasan K, Pepper JR, Warner TD ( 2006 ) . Stronger inhibition by nonsteroid anti-inflammatory drugs of cyclooxygenase-1 in endothelial cells than platelets offers an explanation for increased risk of thrombotic events . FASEB J vol. 20 , ( 14 ) 2468 - 2475 .
Swales KE, Korbonits M, Carpenter R, Walsh DT, Warner TD, Bishop-Bailey D ( 2006 ) . The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression . Cancer Res vol. 66 , ( 20 ) 10120 - 10126 .
Perez-Vizcaino F, Bishop-Bailley D, Lodi F, Duarte J, Cogolludo A, Moreno L, Bosca L, Mitchell JA et al. ( 2006 ) . The flavonoid quercetin induces apoptosis and inhibits JNK activation in intimal vascular smooth muscle cells . Biochem Biophys Res Commun vol. 346 , ( 3 ) 919 - 925 .
Patel TA, Mitchell JA, Warner TD, Harding SE ( 2006 ) . Gram positive bacteria reduce viability and contraction of isolated cardiomyocytes: Role of endothelin-1 . JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY . vol. 40 , 1007 - 1007 .
Bishop-Bailey D, Mitchell JA, Warner TD ( 2006 ) . COX-2 in cardiovascular disease . Arterioscler Thromb Vasc Biol vol. 26 , ( 5 ) 956 - 958 .
Chen GG, Lee TW, Yip JHY, Xu H, Lee IKY, Mok TSK, Warner TD, Yim APC ( 2006 ) . Increased thromboxane B-2 levels are associated with lipid peroxidation and Bcl-2 expression in human lung carcinoma . CANCER LETT vol. 234 , ( 2 ) 193 - 198 .
Warner TD, Vojnovic I, Bishop-Bailey D, Mitchell JA ( 2006 ) . Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2 . FASEB J vol. 20 , ( 3 ) 542 - 544 .
Burke SG, Wainwright CL, Vojnovic I, Warner T, Watson DG, Furman BL ( 2006 ) . The effect of NCX4016 [2-acetoxy-benzoate 2-(2-nitroxymethyl)-phenyl ester] on the consequences of ischemia and reperfusion in the streptozotocin diabetic rat . J PHARMACOL EXP THER vol. 316 , ( 3 ) 1107 - 1114 .
Ali FY, Davidson SJ, Moraes LA, Traves SL, Paul-Clark M, Bishop-Bailey D, Warner TD, Mitchell JA ( 2006 ) . Role of nuclear receptor signaling in platelets: antithrombotic effects of PPAR beta . FASEB J vol. 20 , ( 2 ) 326 - 328 .
Ali FY, Davidson SJ, Moraes LA, Traves SL, Paul-Clark M, Bishop-Bailey D, Warner TD, Mitchell JA ( 2006 ) . Role of nuclear receptor signaling in platelets: antithrombotic effects of PPARbeta . FASEB J vol. 20 , ( 2 ) 326 - 328 .
Ali FY, Egan K, FitzGerald GA, Desvergne B, Wahli W, Bishop-Bailey D, Warner TD, Mitchell JA ( 2006 ) . Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts . Am J Respir Cell Mol Biol vol. 34 , ( 2 ) 242 - 246 .
Mitchell JA, Warner TD ( 2006 ) . COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs . NAT REV DRUG DISCOV vol. 5 , ( 1 ) 75 - 85 .
Li MY, Lee TW, Mok TSK, Warner TD, Yim APC, Chen GG ( 2005 ) . Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth . J CELL BIOCHEM vol. 96 , ( 4 ) 760 - 774 .
Piqueras L, Warner TD, Bishop-Bailey D ( 2005 ) . Expression of peroxisome proliferators-activator receptor-delta and retinoid X receptors in endothelial cells . HEART . vol. 91 ,
Haque ME, Moraes LA, Warner TD, Bishop-Bailey D ( 2005 ) . Farnesoid X receptor ligands inhibited human platelet aggregation induced by ADP . HEART . vol. 91 ,
Wray JA, Williams NP, Warner TD, Bishop-Bailey D ( 2005 ) . PPAR-alpha activation downregulates COX-2 expression in human monocytes . HEART . vol. 91 ,
Moraes LA, Warner TD, Bishop-Bailey D ( 2005 ) . Retinoid X receptor ligands inhibit human platelet aggregation induced by ADP and U46619 . HEART . vol. 91 ,
Jimenez R, Belcher E, Sriskandan S, Lucas R, McMaster S, Vojnovic L, Warner TD, Mitchell JA ( 2005 ) . Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle . P NATL ACAD SCI USA vol. 102 , ( 12 ) 4637 - 4642 .
Lucas R, Warner TD, Vojnovic I, Mitchell JA ( 2005 ) . Cellular mechanisms of acetaminophen: role of cyclooxygenase . FASEB J vol. 19 , ( 2 ) 635 - + .
Zacharowski P, Breese E, Wood E, Del Soldato P, Warner T, Mitchell J ( 2005 ) . NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives . Eur J Pharmacol vol. 508 , ( 1-3 ) 7 - 13 .
Mitchell JA, Warner TD ( 2005 ) . Discontinuation of Vioxx . LANCET vol. 365 , ( 9453 ) 27 - 28 .
Warner T, Ali F, Bishop-Bailey D, Mitchell J, Moraes L ( 2005 ) . Influences of nuclear receptors on platelet . JOURNAL OF VASCULAR RESEARCH . vol. 42 , 24 - 25 .
Rao M, Yang W, Bishop-Bailey D, Warner TD, Seifalian AM, Winslet MC ( 2004 ) . Roles of cyclo-oxygenase 2 and prostanoids in the development of liver metastases from colorectal cancer . BRITISH JOURNAL OF SURGERY . vol. 91 , 1230 - 1230 .
Warner TD, Vojnovic I, Giuliano F, Jiménez R, Bishop-Bailey D, Mitchell JA ( 2004 ) . Cyclooxygenases 1, 2, and 3 and the production of prostaglandin I2: investigating the activities of acetaminophen and cyclooxygenase-2-selective inhibitors in rat tissues . J Pharmacol Exp Ther vol. 310 , ( 2 ) 642 - 647 .
Warner TD, Mitchell JA ( 2004 ) . Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic . FASEB J vol. 18 , ( 7 ) 790 - 804 .
Sasser JM, Woods M, Warner TD, Pollock DM, Pollock JS ( 2004 ) . Role of nuclear factor-kappa B in interleukin-1 beta stimulated endothelin-1 release in inner medullary collecting duct cells . FASEB JOURNAL . vol. 18 , A1322 - A1322 .
Bishop-Bailey D, Walsh DT, Warner TD ( 2004 ) . Expression and activation of the farnesoid X receptor in the vasculature . Proc Natl Acad Sci U S A vol. 101 , ( 10 ) 3668 - 3673 .
Trummlitz G, van Ryn J, Warner TD ( 2004 ) . The molecular and biological basis for COX-2 selectivity . COX-2 Inhibitors ,
Warner TD, Mitchell JA ( 2003 ) . HIF, stretching to get control of VEGF . Clin Sci (Lond) vol. 105 , ( 4 ) 393 - 394 .
Bishop-Bailey D, Warner TD ( 2003 ) . PPARgamma ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator-activated receptor-gamma antagonist . FASEB J vol. 17 , ( 13 ) 1925 - 1927 .
Woods M, Wood EG, Bardswell SC, Bishop-Bailey D, Barker S, Wort SJ, Mitchell JA, Warner TD ( 2003 ) . Role for nuclear factor-kappaB and signal transducer and activator of transcription 1/interferon regulatory factor-1 in cytokine-induced endothelin-1 release in human vascular smooth muscle cells . Mol Pharmacol vol. 64 , ( 4 ) 923 - 931 .
Jimenez R, Warner TD, Belcher PE, Vojnovic I, Mitchell JA ( 2003 ) . Induction of NOSII and COX activity in primary cultures of murine smooth muscle cells . BRITISH JOURNAL OF PHARMACOLOGY . vol. 140 ,
Warner TD, Mitchell JA ( 2003 ) . Nonsteroidal antiinflammatory drugs inhibiting prostanoid efflux: as easy as ABC? . Proc Natl Acad Sci U S A vol. 100 , ( 16 ) 9108 - 9110 .
Wray J, Zeldin D, Warner TD, Bishop-Bailey D ( 2003 ) . Cytochrome P450 2J2 over-expression activates peroxisome proliferator-activated receptor-alpha . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U85 - U85 .
Bishop-Bailey D, Walsh DT, Warner TD ( 2003 ) . Farnesoid X receptor (FXR) as a novel target in vascular smooth muscle cells . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U30 - U30 .
Walters MJ, Warner TD, Bishop-Bailey D, Mitchell JA ( 2003 ) . The PPAR gamma ligand 15-deoxy-Delta(12,14)-prostaglandin J(2) (15D-PGJ(2)) inhibits proliferation and cytokine release from human pulmonary artery smooth muscle . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U66 - U66 .
Thomas MA, Bishop-Bailey D, Warner TD ( 2003 ) . The novel CO releasing compound tricarbonyldichlororuthenium (II) dimer confers protection from free radical mediated cytotoxicity in WKY 3M-22 cell line and primary rat aortic smooth muscle cells . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U84 - U84 .
Thomas MA, Warner TD, Bishop-Bailey D ( 2003 ) . The novel CO releasing compound Tricarbonyldichlororuthenium (11) dimer protects H9C2 rat cardiomyoblasts from free radical mediated cytotoxicity . FASEB JOURNAL . vol. 17 , A618 - A619 .
Gray PA, Warner TD, Vojnovic I, Del Soldato P, Parikh A, Scadding GK, Mitchell JA ( 2002 ) . Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors . Br J Pharmacol vol. 137 , ( 7 ) 1031 - 1038 .
Giuliano F, Warner TD ( 2002 ) . Origins of prostaglandin E2: involvements of cyclooxygenase (COX)-1 and COX-2 in human and rat systems . J Pharmacol Exp Ther vol. 303 , ( 3 ) 1001 - 1006 .
Calatayud S, Warner TD, Breese EJ, Mitchell JA ( 2002 ) . Modulation by colony stimulating factors of human epithelial colon cancer cell apoptosis . CYTOKINE vol. 20 , ( 4 ) 163 - 167 .
Warner TD, Mitchell JA, Vane JR ( 2002 ) . Cyclo-oxygenase-2 inhibitors and cardiovascular events . LANCET vol. 360 , ( 9346 ) 1700 - 1701 .
Wort SJ, Woods M, Warner TD, Evans TW, Mitchell JA ( 2002 ) . Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension . Mol Pharmacol vol. 62 , ( 5 ) 1147 - 1153 .
Warner TD, Mitchell JA ( 2002 ) . Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum? . Proc Natl Acad Sci U S A vol. 99 , ( 21 ) 13371 - 13373 .
McCartney SA, Ballinger AB, Vojnovic I, Farthing MJG, Warner TD ( 2002 ) . Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis . Life Sci vol. 71 , ( 16 ) 1893 - 1904 .
Bishop-Bailey D, Hla T, Warner TD ( 2002 ) . Intimal smooth muscle cells as a target for peroxisome proliferator-activated receptor-gamma ligand therapy . Circ Res vol. 91 , ( 3 ) 210 - 217 .
Sims EC, Rothman MT, Warner TD, Powell MEB ( 2002 ) . Coronary artery brachytherapy . CLIN ONCOL-UK vol. 14 , ( 4 ) 313 - 326 .
McCartney SA, Greaves RRSH, Warner TD, O'Donnell LJD, Domizio P, Farthing MJG ( 2002 ) . Endothelin content, expression, and receptor type in normal and diseased human gallbladder . Dig Dis Sci vol. 47 , ( 8 ) 1786 - 1792 .
Burke SG, Furman BL, Wainwright CL, Del Soldato P, Vojnovic I, Warner T ( 2002 ) . The effect of no-aspirin on arrhythmias & infarct size in hearts isolated from the SHR . J MOL CELL CARDIOL vol. 34 , ( 6 ) A14 - A14 .
Calatayud S, Warner TD, Mitchell JA ( 2002 ) . Modulation of colony stimulating factor release and apoptosis in human colon cancer cells by anticancer drugs . BRIT J CANCER vol. 86 , ( 8 ) 1316 - 1321 .
Calatayud S, Mitchell JA, Perretti M, Giuliano F, Warner TD ( 2002 ) . Effects of cyclooxygenase-1/cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery . EUR J PHARMACOL vol. 440 , ( 1 ) 71 - 77 .
Woods M, Wood EG, Mitchell JA, Bishop-Bailey D, Warner TD ( 2002 ) . Antisense to STAT1/IRF-1 and NF-kappa B inhibits cytokine-stimulated ET-1 release from human vascular smooth muscle cells . BRIT J PHARMACOL . vol. 135 ,
Thomas MA, Bishop-Bailey D, Warner TD ( 2002 ) . Heme oxygenase induction is associated with protection from SIN-1 cytotoxicity in WKY 3M-22 rat aortic smooth muscle cells . BRIT J PHARMACOL . vol. 135 ,
Giuliano F, Vojnovic L, Warner TD ( 2002 ) . Prostacyclin production from intact pat blood vessels is via the activity of cyclooxygenase-1 as defined by naproxen, paracetamol, rofecoxib and SC560 . BRIT J PHARMACOL . vol. 135 ,
Burke SG, Furman BL, Wainwright CL, Del Soldato P, Vojnovic I, Warner T ( 2002 ) . The effect of NO-aspirin on arrhythmias and infarct size in isolated spontaneously hypertensive rat hearts . BRIT J PHARMACOL . vol. 135 ,
Zacharowski K, Rensing H, Frank S, Warner TD ( 2002 ) . Doses of bacterial wall fragment of S-aureus that induce delayed preconditioning do not induce heme oxygenase-1 and inducible nitric oxide synthase . BRIT J PHARMACOL . vol. 135 ,
Gray PA, Vojnovic I, Del Soldato P, Mitchell JA, Warner TD ( 2002 ) . Effects of plasma proteins and blood elements on the potencies of flurbiprofen and NO-flurbiprofen as inhibitors of thromboxane A(2) formation by human platelets . BRIT J PHARMACOL . vol. 135 ,
Kvirkvelia N, Vojnovic I, Warner TD, Athie-Morales V, Free P, Rayment N, Chain BM, Rademacher TW et al. ( 2002 ) . Placentally derived prostaglandin E-2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells . CLIN EXP IMMUNOL vol. 127 , ( 2 ) 263 - 269 .
Bishop-Bailey D, Calatayud S, Warner TD, Hla T, Mitchell JA ( 2002 ) . Prostaglandins and the regulation of tumor growth . J Environ Pathol Toxicol Oncol vol. 21 , ( 2 ) 93 - 101 .
Warner T ( 2002 ) . Valdecoxib - A viewpoint by Tim Warner . DRUGS vol. 62 , ( 14 ) 2072 - 2073 .
Giuliano F, Mitchell JA, Warner TD ( 2001 ) . Sodium salicylate inhibits prostaglandin formation without affecting the induction of cyclooxygenase-2 by bacterial lipopolysaccharide in vivo . J Pharmacol Exp Ther vol. 299 , ( 3 ) 894 - 900 .
Calatayud S, Warner TD, Breese EJ, Mitchell JA ( 2001 ) . Relationship between endogenous colony stimulating factors and apoptosis in human colon cancer cells: role of cyclo-oxygenase inhibitors . BRIT J PHARMACOL . vol. 134 , 1237 - 1244 .
Zacharowski K, Thomas M, Wood EG, Bishop-Bailey D, Warner TD ( 2001 ) . Cardioprotective effect of PPAR gamma receptor agonist rosiglitazone is abolished by cycloheximid or dexamethasone . CIRCULATION . vol. 104 , 53 - 53 .
Giuliano F, Ferraz JG, Pereira R, de Nucci G, Warner TD ( 2001 ) . Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluation . Eur J Pharmacol vol. 426 , ( 1-2 ) 95 - 103 .
Wort SJ, Woods M, Warner TD, Evans TW, Mitchell JA ( 2001 ) . Endogenously released endothelin-1 from human pulmonary artery smooth muscle promotes cellular proliferation - Relevance to pathogenesis of pulmonary hypertension and vascular remodeling . AM J RESP CELL MOL vol. 25 , ( 1 ) 104 - 110 .
Sims EC, Powell MEB, Rothman MT, Warner TD ( 2001 ) . Targeted radioimmunotherapy - Novel delivery of coronary artery radiation . BRIT J CANCER . vol. 85 , 17 - 17 .
Caliendo G, Santagada V, Perissutti E, Severino B, Fiorino F, Warner TD, Wallace JL, Ifa DR et al. ( 2001 ) . Synthesis of substituted benzamides as anti-inflammatory agents that inhibit preferentially cyclooxygenase 1 but do not cause gastric damage . EUR J MED CHEM vol. 36 , ( 6 ) 517 - 530 .
Thomas MA, Bishop-Bailey D, Wood EG, Warner TD ( 2001 ) . Biliverdin, the product of heme oxygenase metabolism attenuates SIN-1 induced apoptosis in WKY 3M-22 rat aortic smooth muscle cells . BRIT J PHARMACOL . vol. 133 , U62 - U62 .
Giuliano F, Warner TD ( 2001 ) . COX-1-derived PGE(2): A comparison between human and rat blood . BRIT J PHARMACOL . vol. 133 , U101 - U101 .
Calatayud S, Allcock GH, Perretti M, Mitchell JA, Warner TD ( 2001 ) . Comparison of the effects of the selective COX-2 inhibitor, DFP, and indomethacin on leukocyte-endothelial cell interactions in the rat mesentery . BRIT J PHARMACOL . vol. 133 , U102 - U102 .
Bardswell SC, Woods M, Bishop-Bailey D, Wood EG, Mitchell JA, Warner TD ( 2001 ) . Effect of peroxisome proliferator-activated receptor agonists on cytokine-stimulated endothelin-1 production in human vascular smooth muscle cells . BRIT J PHARMACOL . vol. 133 , U52 - U52 .
Calatayud S, Warner TD, Mitchell JA ( 2001 ) . Modulation of colony stimulating factor release and apoptosis in human colon cancer cells by anticancer drugs . BRIT J PHARMACOL . vol. 133 , U126 - U126 .
Bishop-Bailey D, Hla T, Warner TD ( 2001 ) . Peroxisome proliferator-activated (PPAR) gamma ligands induce vascular smooth muscle cell apoptosis . BRIT J PHARMACOL . vol. 133 , U18 - U18 .
Gray PA, Breese EJ, Wood EG, Warner TD, Mitchell JA ( 2001 ) . Respective effects of cAMP elevation versus cGMP elevation on GMCSF release by human synoviocytes . BRIT J PHARMACOL . vol. 133 , U21 - U21 .
Price S, Warner TD, Evans TW, Anning PB, Mitchell JA ( 2001 ) . Role of endothelin-1 in modulation of cardiac function in endotoxaemia . BRIT J PHARMACOL . vol. 133 , U4 - U4 .
Warner TD ( 2001 ) . Introduction to "nimesulide: beyond COX-2" . Clin Exp Rheumatol vol. 19 , ( 1 Suppl 22 ) S1 - S2 .
Bennett A, Warner TD ( 2001 ) . Nimesulide: Beyond COX-2 - EULAR Satellite Symposium (22 June 2000) - Foreword . CLIN EXP RHEUMATOL vol. 19 , ( 1 ) II - II .
Roland M, Bhowmik A, Sapsford RJ, Seemungal TA, Jeffries DJ, Warner TD, Wedzicha JA ( 2001 ) . Sputum and plasma endothelin-1 levels in exacerbations of chronic obstructive pulmonary disease . Thorax vol. 56 , ( 1 ) 30 - 35 .
Roland MA, Patel I, Roberts NJ, Sapsford RJ, Warner T, Wedzicha JA ( 2000 ) . The effect of clarithromycin on endothelin-1 production by primary bronchial epithelial cell cultures from COPD patients . THORAX . vol. 55 , A6 - A6 .
Woods M, Wood EG, Mitchell JA, Warner TD ( 2000 ) . Cyclic AMP regulates cytokine stimulation of endothelin-1 release in human vascular smooth muscle cells . J Cardiovasc Pharmacol . vol. 36 , S404 - S406 .
Woods M, Wood EG, Mitchell JA, Warner TD ( 2000 ) . Signal transduction pathways involved in cytokine stimulation of endothelin-1 release from human vascular smooth muscle cells . J Cardiovasc Pharmacol . vol. 36 , S407 - S409 .
Wort SJ, Mitchell JA, Woods M, Evans TW, Warner TD ( 2000 ) . The prostacyclin-mimetic cicaprost inhibits endogenous endothelin-1 release from human pulmonary artery smooth muscle cells . J Cardiovasc Pharmacol . vol. 36 , S410 - S413 .
Vane JR, Warner TD ( 2000 ) . Nomenclature for COX-2 inhibitors . Lancet vol. 356 , ( 9239 ) 1373 - 1374 .
Bishop-Bailey D, Hla T, Warner TD ( 2000 ) . Bisphenol A diglycidyl ether (BADGE) is a PPARgamma agonist in an ECV304 cell line . Br J Pharmacol vol. 131 , ( 4 ) 651 - 654 .
Chen G, Wang SH, Warner TD ( 2000 ) . Regulation of iNOS mRNA levels in endothelial cells by glutathione, a double-edged sword . Free Radic Res vol. 32 , ( 3 ) 223 - 234 .
Mitchell JA, Gray P, Anning PD, Woods M, Warner TD, Evans TW ( 2000 ) . Effects of nitric oxide-modulating amino acids on coronary vessels: relevance to sepsis . Eur J Pharmacol vol. 389 , ( 2-3 ) 209 - 215 .
Mitchell JA, Warner TD ( 1999 ) . Cyclo-oxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapy . Br J Pharmacol vol. 128 , ( 6 ) 1121 - 1132 .
Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR ( 1999 ) . Nonsteroid drug selectives for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis (vol 96, pg 7563, 1999) . PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA vol. 96 , ( 17 ) 9966 - 9966 .
Hamilton LC, Vojnovic I, Warner TD ( 1999 ) . A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner . Br J Pharmacol vol. 127 , ( 7 ) 1589 - 1596 .
Brooks P, Emery P, Evans JF, Fenner H, Hawkey CJ, Patrono C, Smolen J, Breedveld F et al. ( 1999 ) . Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2 . Rheumatology (Oxford) vol. 38 , ( 8 ) 779 - 788 .
McCartney SA, Mitchell JA, Fairclough PD, Farthing MJ, Warner TD ( 1999 ) . Selective COX-2 inhibitors and human inflammatory bowel disease . Aliment Pharmacol Ther vol. 13 , ( 8 ) 1115 - 1117 .
Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR ( 1999 ) . Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis . Proc Natl Acad Sci U S A vol. 96 , ( 13 ) 7563 - 7568 .
Woods M, Mitchell JA, Wood EG, Barker S, Walcot NR, Rees GM, Warner TD ( 1999 ) . Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzyme . Mol Pharmacol vol. 55 , ( 5 ) 902 - 909 .
Giuliano F, Warner TD ( 1999 ) . Ex vivo assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs . Br J Pharmacol vol. 126 , ( 8 ) 1824 - 1830 .
Saunders MA, Belvisi MG, Cirino G, Barnes PJ, Warner TD, Mitchell JA ( 1999 ) . Mechanisms of prostaglandin E2 release by intact cells expressing cyclooxygenase-2: evidence for a 'two-component' model . J Pharmacol Exp Ther vol. 288 , ( 3 ) 1101 - 1106 .
Warner TD ( 1999 ) . Relationships between the endothelin and nitric oxide pathways . Clin Exp Pharmacol Physiol . vol. 26 , 247 - 252 .
Hamilton LC, Mitchell JA, Tomlinson AM, Warner TD ( 1999 ) . Synergy between cyclo-oxygenase-2 induction and arachidonic acid supply in vivo: consequences for nonsteroidal antiinflammatory drug efficacy . FASEB J vol. 13 , ( 2 ) 245 - 251 .
Warner TD ( 1999 ) . Endothelin Receptors and Ligands . Pulmonary Actions of the Endothelins ,
Chen G, Wood EG, Wang SH, Warner TD ( 1999 ) . Expression of cyclooxygenase-2 in rat vascular smooth muscle cells is unrelated to nuclear factor-kappaB activation . Life Sci vol. 64 , ( 14 ) 1231 - 1242 .
Thiemermann C, Warner TD ( 1999 ) . Nitric oxide and endothelin-1 in circulatory shock involving cytokines . Cytokines in Severe Sepsis and Septic Shock ,
Hamilton LC, Warner TD ( 1998 ) . Interactions between inducible isoforms of nitric oxide synthase and cyclo-oxygenase in vivo: investigations using the selective inhibitors, 1400W and celecoxib . Br J Pharmacol vol. 125 , ( 2 ) 335 - 340 .
Chen G, Kamal M, Hannon R, Warner TD ( 1998 ) . Regulation of cyclo-oxygenase gene expression in rat smooth muscle cells by catalase . Biochem Pharmacol vol. 55 , ( 10 ) 1621 - 1631 .
Warner TD, McCartney SA ( 1998 ) . Shock news for the gut . Gut vol. 42 , ( 5 )
McCartney, Ballinger, Azooz O, Warner T, Farthing M ( 1998 ) . Endothelin levels in trinitrobenzenesulphonic acid (TNBS)-induced colitis do not reflect those in human inflammatory bowel disease (IBD) . Gastroenterology vol. 114 ,
McCartney, Vojnovic I, Farthing MJ, Warner T ( 1998 ) . Nonsteroidal drug (NSAID)-induced fall in HT-29 cell viability correlates with potency to inhibit cyclooxygenase (COX) 1: Use of COX-2 selective inhibitors . Gastroenterology vol. 114 ,
McCartney, Mitchell J, Vojnovic I, Farthing M, Warner T ( 1998 ) . Prostanoid production in human inflammatory bowel disease (IBD) is dependent upon cyclo-oxygenase 2: Use of selective inhibitors . Gastroenterology vol. 114 ,
Warner TD, McCartney SA ( 1998 ) . NOS inhibitors in colitis: a suitable case for treatment? . Gut vol. 42 , ( 2 ) 152 - 153 .
D'Amico M, Di Filippo C, Rossi F, Warner TD ( 1998 ) . Role of AT2 receptors in the cardiovascular events following microinjection of angiotensin II into the superior colliculus of anaesthetised rats . Naunyn Schmiedebergs Arch Pharmacol vol. 357 , ( 2 ) 121 - 125 .
Woods M, Bishop-Bailey D, Pepper JR, Evans TW, Mitchell JA, Warner TD ( 1998 ) . Cytokine and lipopolysaccharide stimulation of endothelin-1 release from human internal mammary artery and saphenous vein smooth-muscle cells . J Cardiovasc Pharmacol vol. 31 Suppl 1 , S348 - S350 .
D'Amico M, Rossi F, Warner TD ( 1997 ) . Regulation of blood pressure by L-arginine-nitric oxide pathway within the superior colliculus of rats . Eur J Pharmacol vol. 328 , ( 1 ) 65 - 67 .
Chen G, Warner TD ( 1997 ) . A single competitive reverse transcriptase-polymerase chain reaction assay to measure inducible nitric oxide synthase gene expression in both human and rat . Anal Biochem vol. 247 , ( 2 ) 455 - 458 .
Bishop-Bailey D, Larkin SW, Warner TD, Chen G, Mitchell JA ( 1997 ) . Characterization of the induction of nitric oxide synthase and cyclo-oxygenase in rat aorta in organ culture . Br J Pharmacol vol. 121 , ( 1 ) 125 - 133 .
Takahashi T, Barnes PJ, Kawikova I, Yacoub MH, Warner TD, Belvisi MG ( 1997 ) . Contraction of human airway smooth muscle by endothelin-1 and IRL 1620: effect of bosentan . Eur J Pharmacol vol. 324 , ( 2-3 ) 219 - 222 .
Allcock GH, Warner TD ( 1997 ) . Activation of ET(A) receptors is partially responsible for the rapid increase in haematocrit induced by bacterial lipopolysaccharide in the rat . Life Sci vol. 60 , ( 19 )
D'Amico M, Rossi F, Warner TD ( 1996 ) . Cardiovascular responses induced by injection of endothelin-1 into the superior colliculus of rats . Eur J Pharmacol vol. 316 , ( 2-3 ) 245 - 247 .
Warner TD ( 1996 ) . Influence of endothelial mediators on the vascular smooth muscle and circulating platelets and blood cells . Int Angiol vol. 15 , ( 2 ) 93 - 99 .
Warner TD, Elliott JD, Ohlstein EH ( 1996 ) . California dreamin' 'bout endothelin: emerging new therapeutics . Trends Pharmacol Sci vol. 17 , ( 5 ) 177 - 181 .
D'Amico M, Dashwood MR, Warner TD ( 1996 ) . Endothelin-1 and the periaqueductal gray area of the rat: an autoradiographic and functional pharmacological study . Br J Pharmacol vol. 118 , ( 1 ) 21 - 26 .
Warner TD, Klemm P ( 1996 ) . What turns on the endothelins? . Inflamm Res vol. 45 , ( 2 ) 51 - 53 .
D'Amico M, Warner TD ( 1995 ) . Involvement of endothelin in the pressor response following injection of NMDA to the periaqueductal gray area of rats . Br J Pharmacol vol. 116 , ( 7 ) 2787 - 2789 .
Hohlfeld T, Klemm P, Thiemermann C, Warner TD, Schrör K, Vane JR ( 1995 ) . The contribution of tumour necrosis factor-alpha and endothelin-1 to the increase of coronary resistance in hearts from rats treated with endotoxin . Br J Pharmacol vol. 116 , ( 8 ) 3309 - 3315 .
Allcock GH, Warner TD, Vane JR ( 1995 ) . Roles of endothelin receptors in the regional and systemic vascular responses to ET-1 in the anaesthetized ganglion-blocked rat: use of selective antagonists . Br J Pharmacol vol. 116 , ( 5 ) 2482 - 2486 .
Allcock GH, Battistini B, Fournier A, Warner TD, Vane JR ( 1995 ) . Characterization of endothelin receptors mediating mechanical responses to the endothelins in the isolated stomach strip of the rat . J Pharmacol Exp Ther vol. 275 , ( 1 ) 120 - 126 .
Berthiaume N, Claing A, Regoli D, Warner TD, D'Orléans-Juste P ( 1995 ) . Characterization of receptors for kinins and neurokinins in the arterial and venous mesenteric vasculatures of the guinea-pig . Br J Pharmacol vol. 115 , ( 7 ) 1319 - 1325 .
Battistini B, Botting R, Warner TD ( 1995 ) . Endothelin: a knockout in London . Trends Pharmacol Sci vol. 16 , ( 7 ) 217 - 222 .
Goto K, Warner TD ( 1995 ) . Molecular pharmacology. Endothelin versatility . Nature vol. 375 , ( 6532 ) 539 - 540 .
Swierkosz TA, Mitchell JA, Warner TD, Botting RM, Vane JR ( 1995 ) . Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids . Br J Pharmacol vol. 114 , ( 7 ) 1335 - 1342 .
Bryant CE, Allcock GH, Warner TD ( 1995 ) . Comparison of effects of chronic and acute administration of NG-nitro-L-arginine methyl ester to the rat on inhibition of nitric oxide-mediated responses . Br J Pharmacol vol. 114 , ( 8 ) 1673 - 1679 .
Battistini B, Woods M, O'Donnell LJ, Warner TD, Corder R, Fournier A, Farthing MJ, Vane JR ( 1995 ) . Contractile activity of endothelin precursors in the isolated gallbladder of the guinea-pig: presence of an endothelin-converting enzyme . Br J Pharmacol vol. 114 , ( 7 ) 1383 - 1390 .
Klemm P, Warner TD, Willis D, Moore AR, Vane JR ( 1995 ) . Coronary vasoconstriction in vitro in the hearts of polyarthritic rats: effectiveness of in vivo treatment with the endothelin receptor antagonist SB 209670 . Br J Pharmacol vol. 114 , ( 7 ) 1327 - 1328 .
COOPER AC, PEREZVIZCAINO F, CORDER R, FOURNIER A, WARNER TD ( 1995 ) . RAPID DEGRADATION OF ENDOTHELIN-1 BY AN ENZYME RELEASED BY THE RAT ISOLATED-PERFUSED MESENTERY . BRITISH JOURNAL OF PHARMACOLOGY . vol. 114 , P197 - P197 .
Klemm P, Warner TD, Hohlfeld T, Corder R, Vane JR ( 1995 ) . Endothelin 1 mediates ex vivo coronary vasoconstriction caused by exogenous and endogenous cytokines . Proc Natl Acad Sci U S A vol. 92 , ( 7 ) 2691 - 2695 .
Pérez-Vizcaíno F, Cooper AC, Corder R, Fournier A, Warner TD ( 1995 ) . Rapid degradation of endothelin-1 by an enzyme released by the rat isolated perfused mesentery . Br J Pharmacol vol. 114 , ( 4 ) 867 - 871 .
Klemm P, Warner TD, Corder R, Vane JR ( 1995 ) . Endothelin-1 mediates coronary vasoconstriction caused by exogenous and endogenous cytokines . J Cardiovasc Pharmacol vol. 26 Suppl 3 , S419 - S421 .
Kengatharan M, Battistini B, Warner TD, Thiemermann C, Vane JR ( 1995 ) . Endothelin-1 mediates the increase in ex vivo coronary vascular resistance induced by hemorrhagic shock in the anesthetized rat . J Cardiovasc Pharmacol . vol. 26 Suppl 3 , S422 - S424 .
Warner TD, Dunn MJ, Kimura SK, Stewart DJ, Yanagisawa M, Masaki T, Vane JR ( 1995 ) . Endothelins: Recent Progress . Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s ,
Allcock GH, Warner TD ( 1995 ) . Inhibition of ETB receptors limits the efficacy of nonselective endothelin antagonists in vivo . J Cardiovasc Pharmacol . vol. 26 Suppl 3 , S177 - S179 .
Swierkosz TA, Warner TD, Vane JR ( 1995 ) . NG-Hydroxy-L-Arginine Releases from Endothelial Cells Nitric Oxide which Increases cGMP in RFL-6 Fibroblasts . Endothelium vol. 3 , ( 2 ) 121 - 129 .
Desai KM, Warner TD, Bishop AE, Polak JM, Vane JR ( 1994 ) . Nitric oxide, and not vasoactive intestinal peptide, as the main neurotransmitter of vagally induced relaxation of the guinea pig stomach . Br J Pharmacol vol. 113 , ( 4 ) 1197 - 1202 .
Swierkosz TA, Mitchell JA, Tomlinson A, Botting RM, Warner TD, Vane JR ( 1994 ) . Relationship between different isoforms of nitric oxide synthase and cyclooxygenase in various cell types . Pol J Pharmacol vol. 46 , ( 6 ) 587 - 592 .
Warner TD, Battistini B, Doherty AM, Corder R ( 1994 ) . Endothelin receptor antagonists: actions and rationale for their development . Biochem Pharmacol vol. 48 , ( 4 ) 625 - 635 .
MOYNIHAN HA, ROBERTS SM, WELDON H, ALLCOCK GH, AENGGARD EE, WARNER TD ( 1994 ) . ChemInform Abstract: Synthesis and Biological Activity of the Novel Nitric Oxide Synthase Inhibitor Nω′‐Hydroxy‐Nω‐methyl‐L‐arginine . ChemInform vol. 25 , ( 32 ) no - no .
Battistini B, O'Donnell LJ, Warner TD, Fournier A, Farthing MJ, Vane JR ( 1994 ) . Characterization of endothelin (ET) receptors in the isolated gall bladder of the guinea-pig: evidence for an additional ET receptor subtype . Br J Pharmacol vol. 112 , ( 4 ) 1244 - 1250 .
Warner TD ( 1994 ) . Endothelin Receptor Antagonists . Cardiovascular Therapeutics vol. 12 , ( 2 ) 105 - 122 .
Warner TD, Allcock GH, Vane JR ( 1994 ) . Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065 . Br J Pharmacol vol. 112 , ( 1 ) 207 - 213 .
Korbut R, Warner TD, Gryglewski RJ, Vane JR ( 1994 ) . The effect of nitric oxide synthase inhibition on the plasma fibrinolytic system in septic shock in rats . Br J Pharmacol vol. 112 , ( 1 ) 289 - 291 .
Macarthur H, Warner TD, Wood EG, Corder R, Vane JR ( 1994 ) . Endothelin-1 release from endothelial cells in culture is elevated both acutely and chronically by short periods of mechanical stretch . Biochem Biophys Res Commun vol. 200 , ( 1 ) 395 - 400 .
Battistini B, Warner TD, Fournier A, Vane JR ( 1994 ) . Characterization of ETB receptors mediating contractions induced by endothelin-1 or IRL 1620 in guinea-pig isolated airways: effects of BQ-123, FR139317 or PD 145065 . Br J Pharmacol vol. 111 , ( 4 ) 1009 - 1016 .
Battistini B, Warner TD, Fournier A, Vane JR ( 1994 ) . Comparison of PD 145065 and Ro 46-2005 as antagonists of contractions of guinea-pig airways induced by endothelin-1 or IRL 1620 . Eur J Pharmacol vol. 252 , ( 3 ) 341 - 345 .
Wellings RP, Corder R, Warner TD, Cristol JP, Thiemermann C, Vane JR ( 1994 ) . Evidence from receptor antagonists of an important role for ETB receptor-mediated vasoconstrictor effects of endothelin-1 in the rat kidney . Br J Pharmacol vol. 111 , ( 2 ) 515 - 520 .
Desai KM, Warner TD, Vane JR ( 1994 ) . 5-HT3 receptors do not mediate vagally-induced relaxation or contraction of the isolated stomach of the guinea-pig . Br J Pharmacol vol. 111 , ( 1 ) 346 - 350 .
Warner TD, Mitchell JA, Sheng H, Murad F ( 1994 ) . Effects of cyclic GMP on smooth muscle relaxation . vol. 26 ,
Moynihan HA, Roberts SM, Weldon H, Allcock GH, Änggård EE, Warner TD ( 1994 ) . Synthesis and biological activity of the novel nitric oxide synthase inhibitor N ω′ -hydroxy- N ω -methyl- L -arginine . Journal of the Chemical Society Perkin Transactions 1 vol. 0 , ( 7 ) 769 - 771 .
Warner TD, Battistini B, Allcock GH, Vane JR ( 1993 ) . Endothelin ETA and ETB receptors mediate vasoconstriction and prostanoid release in the isolated kidney of the rat . Eur J Pharmacol vol. 250 , ( 3 ) 447 - 453 .
Warner TD ( 1993 ) . Characterization of endothelin synthetic pathways and receptor subtypes: physiological and pathophysiological implications . Eur Heart J . vol. 14 Suppl I , 42 - 47 .
Warner TD, Allcock GH, Mickley EJ, Vane JR ( 1993 ) . Characterization of endothelin receptors mediating the effects of the endothelin/sarafotoxin peptides on autonomic neurotransmission in the rat vas deferens and guinea-pig ileum . Br J Pharmacol vol. 110 , ( 2 ) 783 - 789 .
D'Orléans-Juste P, Claing A, Warner TD, Yano M, Télémaque S ( 1993 ) . Characterization of receptors for endothelins in the perfused arterial and venous mesenteric vasculatures of the rat . Br J Pharmacol vol. 110 , ( 2 ) 687 - 692 .
Warner TD, Allcock GH, Corder R, Vane JR ( 1993 ) . Use of the endothelin antagonists BQ-123 and PD 142893 to reveal three endothelin receptors mediating smooth muscle contraction and the release of EDRF . Br J Pharmacol vol. 110 , ( 2 ) 777 - 782 .
MITCHELL JA, SWIERKOSZ TA, WARNER TD, GROSS S, THIEMERMANN C, VANE JR ( 1993 ) . REGULATION OF PROSTACYCLIN SYNTHESIS BY THE RELEASE OF ENDOGENOUS NITRIC-OXIDE IN RESPONSE TO BACTERIAL LIPOPOLYSACCHARIDE . BRITISH JOURNAL OF PHARMACOLOGY . vol. 109 , P4 - P4 .
Mitchell JA, Kohlhaas KL, Sorrentino R, Warner TD, Murad F, Vane JR ( 1993 ) . Induction by endotoxin of nitric oxide synthase in the rat mesentery: lack of effect on action of vasoconstrictors . Br J Pharmacol vol. 109 , ( 1 ) 265 - 270 .
Warner TD, Vane JR ( 1993 ) . Pharmacology. ET touches down in Houston . Nature vol. 362 , ( 6420 ) 497 - 498 .
WELLINGS RP, WARNER TD, CORDER R, CRISTOL JP, THIEMERMANN C, VANE JR ( 1993 ) . A NEW NONSELECTIVE ENDOTHELIN ANTAGONIST BLOCKS THE VASOCONSTRICTION INDUCED BY ENDOTHELIN-1 IN THE RAT-KIDNEY, BOTH INVIVO AND INVITRO . BRITISH JOURNAL OF PHARMACOLOGY . vol. 108 , P110 - P110 .
Cristol JP, Warner TD, Thiemermann C, Vane JR ( 1993 ) . Mediation via different receptors of the vasoconstrictor effects of endothelins and sarafotoxins in the systemic circulation and renal vasculature of the anaesthetized rat . Br J Pharmacol vol. 108 , ( 3 ) 776 - 779 .
Warner TD, Allcock GH, Mickley EJ, Corder R, Vane JR ( 1993 ) . Comparative studies with the endothelin receptor antagonists BQ-123 and PD 142893 indicate at least three endothelin receptors . J Cardiovasc Pharmacol vol. 22 Suppl 8 , S117 - S120 .
Kaw S, Warner TD, Vane JR ( 1993 ) . The metabolism of endothelin-1 and big endothelin-1 by the isolated perfused kidney of the rabbit . J Cardiovasc Pharmacol . vol. 22 Suppl 8 , S65 - S68 .
Wellings RP, Warner TD, Thiemermann C, Cristol JP, Corder R, Vane JR ( 1993 ) . Vasoconstriction in the rat kidney induced by endothelin-1 is blocked by PD 145065 . J Cardiovasc Pharmacol vol. 22 Suppl 8 , S103 - S106 .
Schmidt HHHW, Warner TD, Ishii K, Sheng H, Murad F ( 1992 ) . Response . Science vol. 258 , ( 5086 ) 1376 - 1378 .
Matsumoto T, Mitchell JA, Schmidt HH, Kohlhaas KL, Warner TD, Förstermann U, Murad F ( 1992 ) . Nitric oxide synthase in ferret brain: localization and characterization . Br J Pharmacol vol. 107 , ( 3 ) 849 - 852 .
WARNER TD, ALLCOCK GH, CORDER R, VANE JR ( 1992 ) . BQ123 AND DIFFERENT ISOLATED TISSUE PREPARATIONS REVEAL HETEROGENEITY IN THE RECEPTORS MEDIATING CONTRACTIONS TO ENDOTHELIN-1 . BRITISH JOURNAL OF PHARMACOLOGY . vol. 107 , P103 - P103 .
Warner TD, Förstermann U, Ishii K, Mitchell JA, Nakane M, Pollock JS, Schmidt HHHW, Sheng H et al. ( 1992 ) . Bioassay for EDRF/NO by accumulation of cyclic GMP in RFL-6 fetal rat lung fibroblasts . Methods vol. 1 , ( 2 ) 117 - 123 .
Warner TD, Budzik GP, Matsumoto T, Mitchell JA, Förstermann U, Murad F ( 1992 ) . Regional differences in endothelin converting enzyme activity in rat brain: inhibition by phosphoramidon and EDTA . Br J Pharmacol vol. 106 , ( 4 ) 948 - 952 .
Warner TD, Schmidt HH, Kuk J, Mitchell JA, Murad F ( 1992 ) . Human brain contains a metalloprotease that converts big endothelin-1 to endothelin-1 and is inhibited by phosphoramidon and EDTA . Br J Pharmacol vol. 106 , ( 3 ) 505 - 506 .
Mitchell JA, Kohlhaas KL, Matsumoto T, Pollock JS, Förstermann U, Warner TD, Schmidt HH, Murad F ( 1992 ) . Induction of NADPH-dependent diaphorase and nitric oxide synthase activity in aortic smooth muscle and cultured macrophages . Mol Pharmacol vol. 41 , ( 6 ) 1163 - 1168 .
WARNER TD, SCHMIDT H, MURAD F ( 1992 ) . INTERACTIONS OF ENDOTHELINS AND EDRF IN BOVINE NATIVE ENDOTHELIAL-CELLS - SELECTIVE EFFECTS OF ENDOTHELIN-3 . AMERICAN JOURNAL OF PHYSIOLOGY vol. 262 , ( 5 ) H1600 - H1605 .
Warner TD, Schmidt HH, Murad F ( 1992 ) . Interactions of endothelins and EDRF in bovine native endothelial cells: selective effects of endothelin-3 . Am J Physiol vol. 262 , ( 5 Pt 2 ) H1600 - H1605 .
Schmidt HH, Warner TD, Murad F ( 1992 ) . Double-edged role of endogenous nitric oxide . Lancet vol. 339 , ( 8799 )
Schmidt HH, Warner TD, Nakane M, Förstermann U, Murad F ( 1992 ) . Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages . Mol Pharmacol vol. 41 , ( 4 ) 615 - 624 .
Schmidt HH, Warner TD, Ishii K, Sheng H, Murad F ( 1992 ) . Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides . Science vol. 255 , ( 5045 ) 721 - 723 .
Warner TD, Mitchell JA, D'Orleans-Juste P, Ishii K, Förstermann U, Murad F ( 1992 ) . Characterization of endothelin-converting enzyme from endothelial cells and rat brain: detection of the formation of biologically active endothelin-1 by rapid bioassay . Mol Pharmacol vol. 41 , ( 2 ) 399 - 403 .
Mitchell JA, de Nucci G, Warner TD, Vane JR ( 1992 ) . Different patterns of release of endothelium-derived relaxing factor and prostacyclin . Br J Pharmacol vol. 105 , ( 2 ) 485 - 489 .
Kaw S, Hecker M, Southan GJ, Warner TD, Vane JR ( 1992 ) . Characterization of serine protease-derived metabolites of big endothelin in the cytosolic fraction from human polymorphonuclear leukocytes . J Cardiovasc Pharmacol . vol. 20 Suppl 12 , S22 - S24 .
Warner TD, Budzik GP, Mitchell JA, Huang ZJ, Murad F ( 1992 ) . Detection by bioassay and specific enzyme-linked immunosorbent assay of phosphoramidon-inhibitable endothelin-converting activity in brain and endothelium . J Cardiovasc Pharmacol . vol. 20 Suppl 12 , S19 - S21 .
Murad F, Forstermann U, Nakane M, Schmidt H, Pollock J, Sheng H, Matsumoto T, Warner T et al. ( 1992 ) . The nitric oxide-cyclic GMP signal transduction pathway in vascular smooth muscle preparations and other tissues . Jpn J Pharmacol vol. 58 Suppl 2 , 150P - 157P .
Ishii K, Warner TD, Sheng H, Murad F ( 1991 ) . Endothelin increases cyclic GMP levels in LLC-PK1 porcine kidney epithelial cells via formation of an endothelium-derived relaxing factor-like substance . J Pharmacol Exp Ther vol. 259 , ( 3 ) 1102 - 1108 .
Pollock JS, Förstermann U, Mitchell JA, Warner TD, Schmidt HH, Nakane M, Murad F ( 1991 ) . Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells . Proc Natl Acad Sci U S A vol. 88 , ( 23 ) 10480 - 10484 .
D'Orléans-Juste P, Claing A, Télémaque S, Warner TD, Regoli D ( 1991 ) . Neurokinins produce selective venoconstriction via NK-3 receptors in the rat mesenteric vascular bed . Eur J Pharmacol vol. 204 , ( 3 ) 329 - 334 .
Förstermann U, Schmidt HH, Pollock JS, Sheng H, Mitchell JA, Warner TD, Nakane M, Murad F ( 1991 ) . Isoforms of nitric oxide synthase. Characterization and purification from different cell types . Biochem Pharmacol vol. 42 , ( 10 ) 1849 - 1857 .
Ishii K, Sheng H, Warner TD, Förstermann U, Murad F ( 1991 ) . A simple and sensitive bioassay method for detection of EDRF with RFL-6 rat lung fibroblasts . Am J Physiol vol. 261 , ( 2 Pt 2 ) H598 - H603 .
Mitchell JA, de Nucci G, Warner TD, Vane JR ( 1991 ) . Alkaline buffers release EDRF from bovine cultured aortic endothelial cells . Br J Pharmacol vol. 103 , ( 2 ) 1295 - 1302 .
Mitchell JA, Förstermann U, Warner TD, Pollock JS, Schmidt HH, Heller M, Murad F ( 1991 ) . Endothelial cells have a particulate enzyme system responsible for EDRF formation: measurement by vascular relaxation . Biochem Biophys Res Commun vol. 176 , ( 3 ) 1417 - 1423 .
Heller M, Förstermann U, Mitchel J, Pollock JS, Schmidt HHHW, Warner T, Murad F ( 1991 ) . EDRFNO synthesis in bovine aortic endothelial cells: Evidence for soluble and particulate isoenzymes . Journal of Molecular and Cellular Cardiology vol. 23 ,
NAKANE M, HARALD, SCHMIDT HHW, WARNER TD, HUANG ZJ, MURAD F ( 1991 ) . INDUCTION OF TYPE-II GUANYLYL CYCLASE-ACTIVATING-FACTOR (GAF) SYNTHASE IN RAW MACROPHAGES REQUIRES TRANSCRIPTION AND DENOVO-PROTEIN BIOSYNTHESIS . FASEB JOURNAL . vol. 5 , A509 - A509 .
Ishii K, Warner TD, Sheng H, Murad F ( 1991 ) . Endothelin-1 stimulates cyclic GMP formation in porcine kidney epithelial cells via activation of the L-arginine-dependent soluble guanylate cyclase pathway . J Cardiovasc Pharmacol vol. 17 Suppl 7 , S246 - S250 .
D'Orléans-Juste P, Lidbury PS, Telemaque S, Warner TD, Vane JR ( 1991 ) . Human big endothelin releases prostacyclin in vivo and in vitro through a phosphoramidon-sensitive conversion to endothelin-1 . J Cardiovasc Pharmacol . vol. 17 Suppl 7 , S251 - S255 .
Warner TD, D'Orleans-Juste P, Vane JR ( 1990 ) . Endothelin-1 and U46619 potentiate selectively the venous responses to nerve stimulation within the perfused superior mesenteric vascular bed of the rat . Biochem Biophys Res Commun vol. 172 , ( 2 ) 745 - 750 .
D'Orléans-Juste P, Lidbury PS, Warner TD, Vane JR ( 1990 ) . Intravascular big endothelin increases circulating levels of endothelin-1 and prostanoids in the rabbit . Biochem Pharmacol vol. 39 , ( 9 ) R21 - R22 .
Warner TD ( 1990 ) . Simultaneous perfusion of rat isolated superior mesenteric arterial and venous beds: comparison of their vasoconstrictor and vasodilator responses to agonists . Br J Pharmacol vol. 99 , ( 2 ) 427 - 433 .
Warner TD, de Nucci G, Vane JR ( 1989 ) . Comparison of the survival of endothelium-derived relaxing factor and nitric oxide within the isolated perfused mesenteric arterial bed of the rat . Br J Pharmacol vol. 97 , ( 3 ) 777 - 782 .
Warner TD, de Nucci G, Vane JR ( 1989 ) . Rat endothelin is a vasodilator in the isolated perfused mesentery of the rat . Eur J Pharmacol vol. 159 , ( 3 ) 325 - 326 .
Warner TD, Mitchell JA, de Nucci G, Vane JR ( 1989 ) . Endothelin-1 and endothelin-3 release EDRF from isolated perfused arterial vessels of the rat and rabbit . J Cardiovasc Pharmacol vol. 13 Suppl 5 , S85 - S88 .
de Nucci G, Thomas R, D'Orleans-Juste P, Antunes E, Walder C, Warner TD, Vane JR ( 1988 ) . Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor . Proc Natl Acad Sci U S A vol. 85 , ( 24 ) 9797 - 9800 .
de Nucci G, Warner T, Vane JR ( 1988 ) . Effect of captopril on the bradykinin-induced release of prostacyclin from guinea-pig lungs and bovine aortic endothelial cells . Br J Pharmacol vol. 95 , ( 3 ) 783 - 788 .
DENUCCI G, MITCHELL JA, WARNER TD, BEARPARK T, VANE JR ( 1988 ) . RELEASE OF EDRF AND PGI2 FROM BAEC INDUCED BY INFUSIONS OF ADP, BRADYKININ, ARACHIDONIC-ACID, L-ARGININE AND ALKALINE BUFFERS . BRITISH JOURNAL OF PHARMACOLOGY . vol. 95 , P547 - P547 .
de Nucci G, Gryglewski RJ, Warner TD, Vane JR ( 1988 ) . Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled . Proc Natl Acad Sci U S A vol. 85 , ( 7 ) 2334 - 2338 .