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Research

Publications: Prof Ahmad Waseem

Usman S, Aldehlawi H, Nguyen TKN, Teh M-T, Waseem A ( 2022 ) . Impact of N-Terminal Tags on De Novo Vimentin Intermediate Filament Assembly . International Journal of Molecular Sciences vol. 23 , ( 11 ) 6349 - 6349 .
Teh M-T ( 2022 ) . Molecular Signatures of Tumour and Its Microenvironment for Precise Quantitative Diagnosis of Oral Squamous Cell Carcinoma: An International Multi-Cohort Diagnostic Validation Study . Cancers
Teh MT, Ma H, Liang YY, Solomon MC, Chaurasia A, Patil R, Tekade SA, Mishra D et al. ( 2022 ) . Molecular Signatures of Tumour and Its Microenvironment for Precise Quantitative Diagnosis of Oral Squamous Cell Carcinoma: An International Multi-Cohort Diagnostic Validation Study . Cancers vol. 14 , ( 6 )
Usman S ( 2021 ) . Vimentin Is at the Heart of Epithelial Mesenchymal Transition (EMT) Mediated Metastasis . Cancers vol. 13 , ( 19 ) 4985 - 4985 .
Laly AC, Sliogeryte K, Pundel OJ, Ross R, Keeling MC, Avisetti D, Waseem A, Gavara N et al. ( 2021 ) . The keratin network of intermediate filaments regulates keratinocyte rigidity sensing and nuclear mechanotransduction . Science Advances vol. 7 , ( 5 )
Usman S, Jamal A, Teh M-T, Waseem A ( 2021 ) . Major Molecular Signaling Pathways in Oral Cancer Associated With Therapeutic Resistance . Frontiers in Oral Health vol. 1 , 603160 - 603160 .
Lalli A, Aldehlawi H, Buchanan JA, Seoudi N, Fortune F, Waseem A ( 2020 ) . Screening for oral cancer utilising risk-factor analysis is ineffective in high-risk populations . British Journal of Oral and Maxillofacial Surgery
Waseem A, Low S, Shah A, Avisetti D ( 2020 ) . Mutations in SPATA13/ASEF2 cause primary angle closure glaucoma . PLoS Genetics
Aldehlawi H, Usman S, Lalli A, Ahmad F, WILLIAMS G, Teh M-T, Waseem A ( 2020 ) . Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes . Scientific Reports vol. 10 , ( 4829 )
Haider A, Waseem A, Karpukhina N, Mohsin S ( 2020 ) . Strontium- and Zinc-Containing Bioactive Glass and Alginates Scaffolds . Bioengineering vol. 7 , ( 1 )
Yeung J-YS, Hutchison I, Waseem A, Teh M-T ( 2019 ) . qMIDS: A Digital Diagnostic Test for Oral Cancer . British Journal of Oral and Maxillofacial Surgery vol. 57 , ( 10 ) e86 - e87 .
Teh M-T ( 2019 ) . Clinical correlation of opposing molecular signatures in head and neck squamous cell carcinoma . BMC Cancer
ALDEHLAWI H, Niemiec NA, AVISETTI DR, LALLI A, Teh M-T, WASEEM A ( 2019 ) . The monoclonal antibody EPR1614Y against the stem cell biomarker keratin K15 lacks specificity and reacts with other keratins . Scientific Reports vol. 9 , Article 1943 ,
TEH M ( 2018 ) . Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation . Molecular Cancer
Maruthappu T, Chikh A, Fell B, Delaney PJ, Brooke MA, Levet C, Moncada-Pazos A, Ishida-Yamamoto A et al. ( 2017 ) . Rhomboid family member 2 Regulates cytoskeletal stress associated Keratin 16 . Nature Communications vol. 8 , 14174 - 14174 .
Nguyen NT, Mackenzie I, Teh M, Waseem A ( 2015 ) . HOXA7 suppresses keratinocyte differentiation via PKC/AP-1 pathway . MOLECULAR BIOLOGY OF THE CELL . vol. 26 ,
Brown L, Waseem A, Cruz IN, Szary J, Gunic E, Mannan T, Unadkat M, Yang M et al. ( 2014 ) . Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation . Oncogene vol. 33 , ( 18 ) 2363 - 2374 .
Hwang S, Mahadevan S, Qadir F, Hutchison IL, Costea DE, Neppelberg E, Liavaag PG, Waseem A et al. ( 2013 ) . Identification of FOXM1-induced epigenetic markers for head and neck squamous cell carcinomas . Cancer vol. 119 , ( 24 ) 4249 - 4258 .
Bose A, Teh M-T, Mackenzie IC, Waseem A ( 2013 ) . Keratin k15 as a biomarker of epidermal stem cells . Int J Mol Sci vol. 14 , ( 10 ) 19385 - 19398 .
Teh M-T, Hutchison IL, Costea DE, Neppelberg E, Liavaag PG, Purdie K, Harwood C, Wan H et al. ( 2013 ) . Exploiting FOXM1-orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis . Int J Cancer vol. 132 , ( 9 ) 2095 - 2106 .
Pitiyage GN, Lim KP, Gemenitzidis E, Teh M-T, Waseem A, Prime SS, Tilakaratne WM, Fortune F et al. ( 2012 ) . Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 (TIMPs -1 and -2) in fibroblasts are early indicators of oral sub-mucous fibrosis and ageing . J Oral Pathol Med vol. 41 , ( 6 ) 454 - 462 .
Teh M-T, Gemenetzidis E, Patel D, Tariq R, Nadir A, Bahta AW, Waseem A, Hutchison IL ( 2012 ) . FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma . PLoS One vol. 7 , ( 3 )
Bose A, Teh M-T, Hutchison IL, Wan H, Leigh IM, Waseem A ( 2012 ) . Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling . PLoS One vol. 7 , ( 6 )
Gemenetzidis E, Costea DE, Parkinson EK, Waseem A, Wan H, Teh MT ( 2011 ) . Induction of human epithelial stem/progenitor expansion by FOXM1 (Cancer Research (2010) 70, (9515-9526)) . Cancer Research vol. 71 , ( 1 )
Waseem A, Ali M, Odell EW, Fortune F, Teh M-T ( 2010 ) . Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma . Oral Oncol vol. 46 , ( 7 ) 536 - 542 .
Gemenetzidis E, Elena-Costea D, Parkinson EK, Waseem A, Wan H, Teh MT ( 2010 ) . Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1 . Cancer Research vol. 70 , ( 22 ) Article N/A , 9515 - 9526 .
Collier J, Waseem A, Farthing P ( 2009 ) . The chemokine receptor CXCR4 demonstrates several features of a cancer stem cell marker in OSCC . British Journal of Oral and Maxillofacial Surgery vol. 47 , ( 7 )
Gemenetzidis E, Bose A, Riaz AM, Chaplin T, Young BD, Ali M, Sugden D, Thurlow JK et al. ( 2009 ) . FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation . PLoS One vol. 4 , ( 3 )
Paccione RJ, Miyazaki H, Patel V, Waseem A, Gutkind JS, Zehner ZE, Yeudall WA ( 2008 ) . Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility . Mol Cancer Ther vol. 7 , ( 9 ) 2894 - 2903 .
Teh MT, Tilakaratne WM, Chaplin T, Young BD, Ariyawardana A, Pitiyage G, Lalli A, Stewart JE et al. ( 2008 ) . Fingerprinting genomic instability in oral submucous fibrosis . J Oral Pathol Med vol. 37 , ( 7 ) 430 - 436 .
Tilakaratne WM, Iqbal Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Stewart JE, Hagi-Pavli E et al. ( 2008 ) . Upregulation of HIF-1alpha in malignant transformation of oral submucous fibrosis . J Oral Pathol Med vol. 37 , ( 6 ) 372 - 377 .
Lalli A, Tilakaratne WM, Ariyawardana A, Fitchett C, Leigh IM, Hagi-Pavli E, Cruchley AT, Parkinson EK et al. ( 2008 ) . An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity . J Oral Pathol Med vol. 37 , ( 4 ) 211 - 220 .
KÖSE O, WASEEM A ( 2008 ) . Keloids and Hypertrophic Scars . Dermatologic Surgery vol. 34 , ( 3 ) 336 - 346 .
Köse O, Waseem A ( 2008 ) . Keloids and hypertrophic scars: are they two different sides of the same coin? . Dermatol Surg vol. 34 , ( 3 ) 336 - 346 .
Kose O, Stewart J, Waseem A, Lalli A, Fortune F ( 2008 ) . Expression of cytokeratins, adhesion and activation molecules in oral ulcers of Behcet's disease . CLIN EXP DERMATOL vol. 33 , ( 1 ) 62 - 69 .
Collier JM, Waseem A, Farthing P ( 2007 ) . Characterisation of chemokine receptor expression by oral squamous cell carcinoma cells in vitro . British Journal of Oral and Maxillofacial Surgery vol. 45 , ( 7 )
Collier JM, Waseem A, Farthing P ( 2007 ) . Overexpression of the chemokine receptor CXCR4 is associated with lymph node metastasis in patients with HNSCC . British Journal of Oral and Maxillofacial Surgery vol. 45 , ( 7 )
Collier JM, Waseem A, Adegun O, Farthing P ( 2007 ) . Overexpression of the chemokine receptor CXCR4 results in an aggressive OSCC tumour phenotype in vitro . British Journal of Oral and Maxillofacial Surgery vol. 45 , ( 7 )
Köse O, Lalli A, Kutulola AO, Odell EW, Waseem A ( 2007 ) . Changes in the expression of stem cell markers in oral lichen planus and hyperkeratotic lesions . J Oral Sci vol. 49 , ( 2 ) 133 - 139 .
Tilakaratne W, Iqbal Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Hagi-Pavli E, Lalli A et al. ( 2007 ) . P245 Up regulation of HIF-1a in the progression and malignant transformation of oral submucous fibrosis . Oral Oncology Supplement vol. 2 , ( 1 ) 204 - 205 .
Tilakaratne W, Iqball Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Hagi-Pavli E, Lalli A et al. ( 2007 ) . Up regulation of HIF-1 alpha in the progression and malignant transformation of oral submucous fibrosis . ORAL ONCOLOGY . vol. 2 , 204 - 205 .
WASEEM A ( 2006 ) . The skin . Embryos, Genes and Birth Defects , Editors: Ferretti, P, Copp, A, Tickle, C, Moore, G et al. , Wiley
Radoja N, Stojadinovic O, Waseem A, Tomic-Canic M, Milisavljevic V, Teebor S, Blumenberg M ( 2004 ) . Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription . Mol Cell Biol vol. 24 , ( 8 ) 3168 - 3179 .
Waseem A, Karsten U, Leigh IM, Purkis P, Waseem NH, Lane EB ( 2004 ) . Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability . Biochemistry vol. 43 , ( 5 ) 1283 - 1295 .
Bowen SL, Bloor BK, Leigh IM, Waseem A ( 2003 ) . Adducin expression in cutaneous and oral lesions: alpha- and beta-adducin transcripts down-regulate with keratinocyte differentiation in stratified epithelia . J Pathol vol. 201 , ( 1 ) 119 - 126 .
Bloor BK, Tidman N, Leigh IM, Odell E, Dogan B, Wollina U, Ghali L, Waseem A ( 2003 ) . Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization . Am J Pathol vol. 162 , ( 3 ) 963 - 975 .
LEIGH IM, Waseem A, Ghali L, Wollina U, Odell E, Bloor BK, Tidman N, Dogan B ( 2003 ) . Expression of keratin k2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation and keratinization . Am. J. Pathol. vol. 162 , 963 - 975 .
Ditzel HJ, Strik MCM, Larsen MK, Willis AC, Waseem A, Kejling K, Jensenius JC ( 2002 ) . Cancer-associated cleavage of cytokeratin 8/18 heterotypic complexes exposes a neoepitope in human adenocarcinomas . J Biol Chem vol. 277 , ( 24 ) 21712 - 21722 .
Ola A, Waga S, Ellison V, Stillman B, McGurk M, Leigh IM, Waseem NH, Waseem A ( 2001 ) . Human-Saccharomyces cerevisiae proliferating cell nuclear antigen hybrids: oligomeric structure and functional characterization using in vitro DNA replication . J Biol Chem vol. 276 , ( 13 ) 10168 - 10177 .
Waseem A, Dogan B, Tidman N, Alam Y, Purkis P, Jackson S, Lalli A, Machesney M et al. ( 1999 ) . Keratin 15 expression in stratified epithelia: Downregulation in activated keratinocytes . Journal of Investigative Dermatology vol. 112 , ( 3 ) 362 - 369 .
Waseem A, Alam Y, Dogan B, White KN, Leigh IM, Waseem NH ( 1998 ) . Erratum: Isolation, sequence and expression of the gene encoding human keratin 13 (Gene (1998) 215 (269-279) PII: S0378111997002972) . Gene vol. 221 , ( 2 )
Waseem A, Alam Y, Dogan B, White KN, Leigh IM, Waseem NH ( 1998 ) . Isolation, sequence and expression of the gene encoding human keratin 13 . Gene vol. 215 , ( 2 ) 269 - 279 .
Machesney M, Tidman N, Waseem A, Kirby L, Leigh I ( 1998 ) . Activated keratinocytes in the epidermis of hypertrophic scars . American Journal of Pathology vol. 152 , ( 5 ) 1133 - 1141 .
Waseem A, White K, Waseem NH ( 1997 ) . Identification of a novel keratin epitope: Evidence for association between non-helical sub-domains L12 during filament assembly . International Journal of Biochemistry and Cell Biology vol. 29 , ( 7 ) 971 - 983 .
Fu L, Suen CKM, Waseem A, White KN ( 1997 ) . Variable requirement for splicing signals for nucleocytoplasmic export of mRNAs . Biochemistry and Molecular Biology International vol. 42 , ( 2 ) 329 - 337 .
Waseem A, Lane EB, Harrison D, Waseem N ( 1996 ) . A keratin antibody recognizing a heterotypic complex: Epitope mapping to complementary locations on both components of the complex . Experimental Cell Research vol. 223 , ( 2 ) 203 - 214 .
Su L, Morgan PR, Harrison DL, Waseem A, Lane EB ( 1993 ) . Expression of keratin mRNAS and proteins in normal salivary epithelia and pleomorphic adenomas . The Journal of Pathology vol. 171 , ( 3 ) 173 - 181 .
Waseem A, Alexander CM, Steel JB, Lane EB ( 1990 ) . Embryonic simple epithelial keratins 8 and 18: Chromosomal location emphasizes difference from other keratin pairs . New Biologist vol. 2 , ( 5 ) 464 - 478 .
Waseem A, Palfrey HC ( 1990 ) . Identification and protein kinase C-dependent phosphorylation of α-adducin in human fibroblasts . Journal of Cell Science vol. 96 , ( 1 ) 93 - 98 .
Waseem A, Gough AC, Spurr NK, Lane EB ( 1990 ) . Localization of the gene for human simple epithelial keratin 18 to chromosome 12 using polymerase chain reaction . Genomics vol. 7 , ( 2 ) 188 - 194 .
Rogalski AA, Steck TL, Waseem A ( 1989 ) . Association of glyceraldehyde-3-phosphate dehydrogenase with the plasma membrane of the intact human red blood cell . Journal of Biological Chemistry vol. 264 , ( 11 ) 6438 - 6446 .
Waseem A, Steck TL ( 1989 ) . Protein associations with band 3 at cytoplasmic surface of human erythrocyte membrane . Methods in Enzymology vol. 173 , ( C ) 513 - 519 .
WASEEM A, PALFREY HC ( 1988 ) . Erythrocyte adducin: Comparison of the α‐ and β‐subunits and multiple‐site phosphorylation by protein kinase C and cAMP‐dependent protein kinase . European Journal of Biochemistry vol. 178 , ( 2 ) 563 - 573 .
Palfrey HC, Waseem A ( 1988 ) . Protein kinase C and its associated substrates in the human erythrocyte . Society of General Physiologists series vol. 43 , 357 - 369 .
Waseem A, Anwar K ( 1987 ) . Glycoprotein - concanavalin A interaction: Role of protein conformation in the specific interaction of glycoprotein with concanavalin A . Biomedica Biochimica Acta vol. 46 , ( 1 ) 23 - 32 .
Palfrey HC, Waseem A ( 1985 ) . Protein kinase C in the human erythrocyte. Translocation to the plasma membrane and phosphorylation of bands 4.1 and 4.9 and other membrane proteins . Journal of Biological Chemistry vol. 260 , ( 29 ) 16021 - 16029 .
Waseem A, Salahuddin A ( 1983 ) . Anomalous temperature-dependence of the specific interaction of concanavalin A with a multivalent ligand-dextran . Biochim Biophys Acta vol. 746 , ( 1-2 ) 65 - 71 .
Salahuddin A, Waseem A, Khan MY, Qasim MA, Sibghatullah ( 1983 ) . A possible relation between the salting-out behaviour of proteins & their surface hydrophobicity . Indian Journal of Biochemistry and Biophysics vol. 20 , ( 3 ) 127 - 131 .