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Research

Publications: Prof Christoph Thiemermann

Zechendorf E, Schröder K, Stiehler L, Frank N, Beckers C, Kraemer S, Dreher M, Kersten A et al. ( 2022 ) . The Potential Impact of Heparanase Activity and Endothelial Damage in COVID-19 Disease . J Clin Med vol. 11 , ( 18 )
Alves GF, Stoppa I, Aimaretti E, Monge C, Mastrocola R, Porchietto E, Einaudi G, Collotta D et al. ( 2022 ) . ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis . Frontiers in Immunology vol. 13 ,
Patel NM, Collotta D, Aimaretti E, Ferreira Alves G, Kröller S, Coldewey SM, Collino M, Thiemermann C ( 2022 ) . Inhibition of the JAK/STAT Pathway with Baricitinib Reduces the Multiple Organ Dysfunction Caused by Hemorrhagic Shock in Rats . Ann Surg
Mohammad S, O’Riordan CE, Verra C, Aimaretti E, Alves GF, Dreisch K, Evenäs J, Gena P et al. ( 2022 ) . RG100204, A Novel Aquaporin-9 Inhibitor, Reduces Septic Cardiomyopathy and Multiple Organ Failure in Murine Sepsis . Frontiers in Immunology vol. 13 ,
Tillman L, Tabish TA, Kamaly N, Moss P, El-briri A, Thiemermann C, Pranjol MZI, Yaqoob MM ( 2022 ) . Advancements in nanomedicines for the detection and treatment of diabetic kidney disease . Biomaterials and Biosystems vol. 6 ,
Patel NM, Yamada N, Oliveira FRMB, Stiehler L, Zechendorf E, Hinkelmann D, Kraemer S, Stoppe C et al. ( 2022 ) . Inhibition of Macrophage Migration Inhibitory Factor Activity Attenuates Haemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats . Frontiers in Immunology vol. 13 ,
Sheikh MH, Errede M, d'Amati A, Khan NQ, Fanti S, Loiola RA, McArthur S, Purvis GSD et al. ( 2022 ) . Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood-brain barrier: Therapeutic avenues . FASEB Journal vol. 36 , ( 1 )
Alves GF, Aimaretti E, Einaudi G, Mastrocola R, de Oliveira JG, Collotta D, Porchietto E, Aragno M et al. ( 2022 ) . Pharmacological Inhibition of FAK-Pyk2 Pathway Protects Against Organ Damage and Prolongs the Survival of Septic Mice . Front Immunol vol. 13 ,
Patel NM, Oliveira FRMB, Ramos HP, Aimaretti E, Alves GF, Coldewey SM, Collino M, Sordi R et al. ( 2021 ) . Inhibition of Bruton's Tyrosine Kinase Activity Attenuates Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats . Ann Surg
Mohammad S, Al Zoubi S, Krieg N, Wissuwa B, Baragetti A, Solito E, Brandenburg K, Collino M et al. ( 2021 ) . A synthetic peptide designed to neutralise lipopolysaccharides attenuates metaflammation and diet-induced metabolic derangements in mice . BRITISH JOURNAL OF PHARMACOLOGY . vol. 178 , 4998 - 4999 .
Peine A, Hallawa A, Bickenbach J, Dartmann G, Fazlic LB, Schmeink A, Ascheid G, Thiemermann C et al. ( 2021 ) . Development and validation of a reinforcement learning algorithm to dynamically optimize mechanical ventilation in critical care . npj Digital Medicine vol. 4 , ( 1 )
Mohammad S, Zoubi SA, Collotta D, Krieg N, Wissuwa B, Alves GF, Purvis GSD, Norata GD et al. ( 2021 ) . A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice . Frontiers in Immunology vol. 12 , 701275 - 701275 .
Thaventhiran A, Thiemermann C, Brohi K, Tremoleda J, Davenport R ( 2021 ) . O1: DISCOVERING NOVEL THERAPEUTICS TO TREAT ACUTE TRAUMATIC COAGULOPATHY (ATC) . British Journal of Surgery vol. 108 , ( Supplement_1 )
Todorović Z, Ðurašević S, Stojković M, Grigorov I, Pavlović S, Jasnić N, Tosti T, Macut JB et al. ( 2021 ) . Lipidomics provides new insight into pathogenesis and therapeutic targets of the ischemia—reperfusion injury . International Journal of Molecular Sciences vol. 22 , ( 6 ) 1 - 18 .
Mohammad S, Thiemermann C ( 2021 ) . Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions . Frontiers in Immunology vol. 11 ,
Alliouachene S, Kieswich J, Bilanges B, Mccafferty K, Thiemermann C, Vanhaesebroeck B, Yaqoob MM ( 2020 ) . Uninephrectomy and class II PI3K-C2β inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice . American Journal of Transplantation
Praditsuktavorn B, Wall J, Thiemermann C, Tremoleda JL, Brohi K ( 2020 ) . Rescuing Cardiac Dysfunction Following Traumatic Haemorrhagic Injury . CIRCULATION . vol. 142 , E496 - E497 .
Zechendorf E, Vaßen P, Zhang J, Hallawa A, Martincuks A, Krenkel O, Müller-Newen G, Schuerholz T et al. ( 2020 ) . Corrigendum: Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-in-Silico Approach Combining In Vitro Experiments and Machine Learning (Front. Immunol, (2018), 9, (393), 10.3389/fimmu.2018.00393) . Frontiers in Immunology vol. 11 ,
Bertocchi I, Foglietta F, Collotta D, Eva C, Brancaleone V, Thiemermann C, Collino M ( 2020 ) . The hidden role of NLRP3 inflammasome in obesity-related COVID-19 exacerbations: Lessons for drug repurposing . British Journal of Pharmacology vol. 177 , ( 21 ) 4921 - 4930 .
O'Riordan CE, Purvis GSD, Collotta D, Krieg N, Wissuwa B, Sheikh MH, Ferreira Alves G, Mohammad S et al. ( 2020 ) . X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure . Frontiers in Immunology vol. 11 ,
Schroth J, Thiemermann C, Henson SM ( 2020 ) . Senescence and the Aging Immune System as Major Drivers of Chronic Kidney Disease . Frontiers in Cell and Developmental Biology vol. 8 , 564461 - 564461 .
Radermacher P, Billiar TR, Ghezzi P, Martin L, Thiemermann C ( 2020 ) . Editorial: Translational Insights Into Mechanisms and Therapy of Organ Dysfunction in Sepsis and Trauma . Frontiers in Immunology vol. 11 ,
Kieswich JE, Chen J, Alliouachene S, Caton PW, McCafferty K, Thiemermann C, Yaqoob MM ( 2020 ) . Immunohistochemistry of Kidney a-SMA, Collagen 1, and Collagen 3, in A Novel Mouse Model of Reno-cardiac Syndrome . Bio Protoc vol. 10 , ( 18 )
Chen J, Purvis GSD, Collotta D, Zoubi SA, Sugimoto MA, Cacace A, Martin L, Colas RA et al. ( 2020 ) . RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial Clearance . Frontiers in Immunology vol. 11 , 2080 - 2080 .
Collotta D, Hull W, Mastrocola R, Chiazza F, Cento A, Murphy C, Verta R, Alves GF et al. ( 2020 ) . Baricitinib counteractsmetaflammation thus protecting against diet-induced metabolic abnormalities in mice . DIABETOLOGIA . vol. 63 , S241 - S242 .
Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S et al. ( 2020 ) . Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia . Journal of Molecular Medicine
Purvis GSD, Collino M, Aranda-Tavio H, Chiazza F, O'Riordan CE, Zeboudj L, Mohammad S, Collotta D et al. ( 2020 ) . Inhibition of Bruton's tyrosine kinase regulates macrophage NF-κB and NLRP3 inflammasome activation in metabolic inflammation . Br J Pharmacol
O'Riordan C, Purvis G, Collotta D, Wissuwa B, Mohammad S, Coldewey SM, Collino M, Greaves D et al. ( 2020 ) . X-LINKED IMMUNE DEFECT MICE ARE PROTECTED AGAINST SEPSIS-INDUCED CARDIAC DYSFUNCTION . SHOCK . vol. 53 , 97 - 97 .
Bangash MN, Abbott TEF, Patel NSA, Hinds C, Thiemermann C, Pearse R ( 2020 ) . The Effect of β2-Adrenoceptor Agonists on Leucocyte-Endothelial Adhesion in a Rodent Model of Laparotomy and Endotoxemia . Frontiers in Immunology vol. 11 ,
Collotta D, Hull W, Mastrocola R, Chiazza F, Cento AS, Murphy C, Verta R, Alves GF et al. ( 2020 ) . Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice . Molecular Metabolism vol. 39 ,
Zechendorf E, O'Riordan CE, Stiehler L, Wischmeyer N, Chiazza F, Collotta D, Denecke B, Ernst S et al. ( 2020 ) . Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis . JCI Insight vol. 5 , ( 8 )
Lopez Tremoleda J, Wall J, Naganathar V, Praditsuktavorn B, Bugg O, Mcarthur S, Thiemermann C, Brohi K ( 2019 ) . Modelling cardiac dysfunction following traumatic haemorrhage injury: impact on myocardial integrity . Frontiers in Immunology vol. 10 ,
O'Riordan CE, Purvis GSD, Collotta D, Chiazza F, Wissuwa B, Al Zoubi S, Stiehler L, Martin L et al. ( 2019 ) . Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice . Frontiers in Immunology vol. 10 ,
Randall DW, Kieswich J, Swann J, McCafferty K, Thiemermann C, Curtis M, Hoyles L, Yaqoob MM ( 2019 ) . Batch effect exerts a bigger influence on the rat urinary metabolome and gut microbiota than uraemia: A cautionary tale . Microbiome vol. 7 , ( 1 )
Martin L, Derwall M, Al Zoubi S, Zechendorf E, Reuter DA, Thiemermann C, Schuerholz T ( 2019 ) . Response . Chest vol. 156 , ( 3 ) 636 - 637 .
Purvis GS, O'Riordan C, Aranda H, Bunyard P, Greaves DR, Thiemermann C ( 2019 ) . Ibrutinib has anti-inflammatory and anti-diabetic effects in a model of HFD-induced insulin resistance and diabetic nephropathy . BRITISH JOURNAL OF PHARMACOLOGY . vol. 176 , 2997 - 2997 .
Sordi R, Chiazza F, Collotta D, Migliaretti G, Colas RA, Vulliamy P, Brohi K, Dalli J et al. ( 2019 ) . Resolvin D1 Attenuates the Organ Injury Associated With Experimental Hemorrhagic Shock . Ann Surg
Stiehler L, Riordan CO, Zechendorf E, Coldewey S, Wissuwa B, Dohmen F, Hinkelmann D, Ostareck-Lederer A et al. ( 2019 ) . THE ROLE OF RIBONUCLEASE A AS POTENTIAL NEW THERAPEUTIC IN SEPTIC CARDIOMYOPATHY . SHOCK . vol. 51 , 83 - 84 .
SOLITO EGLE, PURVIS G, THIEMERMANN C ( 2019 ) . Annexin-A1: therapeutic potential in microvascular disease . Frontiers in Immunology
VOISIN M, leoni G, WOODFIN A, loumagne L, PATEL N, Di Paola R, Cuzzocrea S, THIEMERMANN C et al. ( 2019 ) . Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury . Journal of Pathology vol. 248 , ( 1 ) 88 - 102 .
Martin L, Derwall M, Al Zoubi S, Zechendorf E, Reuter DA, Thiemermann C, Schuerholz T ( 2019 ) . Response . Chest vol. 155 , ( 3 ) 647 - 648 .
Martin L, Derwall M, Al Zoubi S, Zechendorf E, Reuter DA, Thiemermann C, Schuerholz T ( 2019 ) . The Septic Heart: Current Understanding of Molecular Mechanisms and Clinical Implications . Chest vol. 155 , ( 2 ) 427 - 437 .
Purvis GSD, Collino M, Loiola RA, Baragetti A, Chiazza F, Brovelli M, Sheikh MH, Collotta D et al. ( 2019 ) . Identification of Annexina1 as an endogenous regulator of RhoA, and its role in the pathophysiology and experimental therapy of type-2 diabetes . Frontiers in Immunology vol. 10 , ( MAR )
Zingarelli B, Coopersmith CM, Drechsler S, Efron P, Marshall JC, Moldawer L, Wiersinga WJ, Xiao X et al. ( 2019 ) . Part I: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Study Design and Humane Modeling Endpoints . Shock vol. 51 , ( 1 ) 10 - 22 .
Barry SP, Ounzain S, McCormick J, Scarabelli TM, Chen-Scarabelli C, Saravolatz LII, Faggian G, Mazzucco A et al. ( 2019 ) . Retraction notice to “Enhanced IL-17 signalling following myocardial ischaemia/reperfusion injury” [Int. J. Cardiol. 163 (2013) 326–334](S0167527311017050)(10.1016/j.ijcard.2011.08.849) . International Journal of Cardiology vol. 274 ,
Andrikopoulos P, Kieswich J, Pacheco S, Nadarajah L, Harwood SM, O’Riordan CE, Thiemermann C, Yaqoob MM ( 2019 ) . The MEK inhibitor trametinib ameliorates kidney fibrosis by suppressing ERK1/2 and mTORC1 signaling . Journal of the American Society of Nephrology vol. 30 , ( 1 ) 33 - 49 .
Osuchowski MF, Hellman J, Huber-Lang M, Libert C, Remick DG, Thiemermann C, Zingarelli B ( 2019 ) . The Response to the Letter to the Editor Titled: " Is Triple Self-plagiarism "OK" If Only Made Transparent? " by Volker R Jacobs, MD, MBA . Shock vol. 51 , ( 1 ) 140 - 141 .
Al Zoubi S, Chen J, Murphy C, Martin L, Chiazza F, Collotta D, Yaqoob MM, Collino M et al. ( 2018 ) . Linagliptin Attenuates the Cardiac Dysfunction Associated With Experimental Sepsis in Mice With Pre-existing Type 2 Diabetes by Inhibiting NF-κB . Frontiers in Immunology vol. 9 ,
Kieswich JE, Chen J, Alliouachene S, Caton PW, McCafferty K, Thiemermann C, Yaqoob MM ( 2018 ) . A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain 11 Medical and Health Sciences 1103 Clinical Sciences 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology . BMC Nephrology vol. 19 , ( 1 )
Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM et al. ( 2018 ) . Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis (Infection, (2018), 46, 5, (687-691), 10.1007/s15010-018-1183-8) . Infection vol. 46 , ( 5 ) 745 - 747 .
Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM et al. ( 2018 ) . Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis . Infection vol. 46 , ( 5 ) 687 - 691 .
Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM et al. ( 2018 ) . Minimum quality threshold in pre-clinical sepsis studies (mqtipss): An international expert consensus initiative for improvement of animal modeling in sepsis . Shock vol. 50 , ( 4 ) 377 - 380 .
Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon J-M, Chaudry IH, Coopersmith CM et al. ( 2018 ) . Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis . Intensive Care Medicine Experimental vol. 6 , ( 1 ) 26 - 26 .
Chen J, Hamers AJP, Finsterbusch M, Massimo G, Zafar M, Corder R, Colas RA, Dalli J et al. ( 2018 ) . Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis . FASEB Jfj201701303R - fj201701303R .
Khan AI, Kapoor A, Chen J, Martin L, Rogazzo M, Mercier T, Decosterd L, Collino M et al. ( 2018 ) . The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction . Shock vol. 49 , ( 6 ) 675 - 681 .
Khan AI, Kapoor A, Chen J, Martin L, Rogazzo M, Mercier T, Decosterd L, Collino M et al. ( 2018 ) . The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction . Shock vol. 49 , ( 6 ) 675 - 681 .
Aswani A, Manson J, Itagaki K, Chiazza F, Collino M, Wupeng WL, Chan TK, Wong WSF et al. ( 2018 ) . Scavenging circulating mitochondrial DNA as a potential therapeutic option for multiple organ dysfunction in trauma hemorrhage . Frontiers in Immunology vol. 9 , ( MAY )
Busch D, Kapoor A, Rademann P, Hildebrand F, Bahrami S, Thiemermann C, Osuchowski MF ( 2018 ) . Delayed activation of PPAR-β/δ improves long-term survival in mouse sepsis: effects on organ inflammation and coagulation . Innate Immunity vol. 24 , ( 4 ) 262 - 273 .
Zechendorf E, Vaßen P, Zhang J, Hallawa A, Martincuks A, Krenkel O, Müller-Newen G, Schuerholz T et al. ( 2018 ) . Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-In silico Approach Combining In vitro Experiments and Machine Learning . Front Immunol vol. 9 , 393 - 393 .
Martin L, Thiemermann C ( 2018 ) . Mitochondrial DNA in acute kidney injury: Chicken or egg? . Shock vol. 49 , ( 3 ) 352 - 353 .
Purvis GSD, Chiazza F, Chen J, Loiola RA, Martin L, Fountoulakis N, Gnudi L, Collino M et al. ( 2017 ) . Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes . Diabetologia
Briegel J, Möhnle P, Vogeser M, Thiemermann C, Radermacher P ( 2017 ) . Relative adrenal insufficiency in cardiogenic shock: Is there a need for action? . Shock vol. 48 , ( 4 ) 498 - 499 .
Sordi R, Nandra KK, Chiazza F, Johnson FL, Cabrera CP, Torrance HD, Yamada N, Patel NSA et al. ( 2017 ) . Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation . Ann Surg vol. 265 , ( 2 ) 408 - 417 .
Johnson FL, Patel NSA, Purvis GSD, Chiazza F, Chen J, Sordi R, Hache G, Merezhko VV et al. ( 2017 ) . Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis . J Am Heart Assoc vol. 6 , ( 7 )
Martin L, Derwall M, Thiemermann C, Schürholz T ( 2017 ) . Heart in sepsis: Molecular mechanisms, diagnosis and therapy of septic cardiomyopathy . Anaesthesist vol. 66 , ( 7 ) 479 - 490 .
Martin L, Gombert A, Chen J, Liebens J, Verleger J, Kalder J, Marx G, Jacobs M et al. ( 2017 ) . The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men . Front Immunol vol. 8 , 681 - 681 .
Yamada N, Martin L, Zechendorf E, Chiazza F, Varrone B, Collino M, Shepherd J, Heinbockel L et al. ( 2017 ) . A NOVEL SYNTHETIC, HOST-DEFENCE PEPTIDE PROTECTS AGAINST ORGAN INJURY/DYSFUNCTION IN A RAT-MODEL OF SEVERE HEMORRHAGIC SHOCK . vol. 47 , is. 6 , pp. 116 - 117 .
Martin L, Chen J, Zechendorf E, Chiazza F, Oggero S, Collino M, Marx G, Schuerholz T et al. ( 2017 ) . ROLE OF THE beta-D-ENDOGLUCURONIDASE HEPARANASE IN SEPTIC CARDIOMYOPATHY . SHOCK . Conference: European Shock Society vol. 47 , 129 - 129 .
Tremoleda JL, Watts SA, Reynolds PS, Thiemermann C, Brohi K ( 2017 ) . Modelling Acute Traumatic Haemorrhagic Shock Injury: Challenges and Guidelines for Preclinical Studies . Shock
Osuchowski MF, Thiemermann C, Remick DG ( 2017 ) . Sepsis-3 on the Block: What Does It Mean for Preclinical Sepsis Modeling? . Shock vol. 47 , ( 5 ) 658 - 660 .
Purvis GSD, Chiazza F, Collino M, Solito E, Thiemermann C ( 2017 ) . Endogenous Annexin-A1 is a Protective Determinant in HFD-induced Insulin Resistance and Diabetic Nephropathy . FASEB JOURNAL . Conference: FASEB vol. 31 ,
Kalbitz M, Waller C, Huber-Lang M, Gebhard F, Thiemermann C, Radermacher P ( 2017 ) . OXYGEN in the HEART: HOW MUCH IS TOO MUCH? . Shock vol. 47 , ( 4 ) 531 - 532 .
Yamada N, Lukas M, Zechendorf E, Purvis G, Chiazzo F, Varone B, Collino M, Shepherd J et al. ( 2017 ) . Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock . Annals of Surgery
Purvis GSD, Chiazza F, Solito E, Collino M, Thiemermann C ( 2017 ) . Endogenous annexin-A1 is a protective determinant in high-fat diet (HFD)-induced insulin resistance and diabetic nephropathy . DIABETIC MEDICINE . Conference: European Shock Society vol. 34 , 26 - 26 .
Davenport RA, Guerreiro M, Frith D, Rourke C, Platton S, Cohen M, Pearse R, Thiemermann C et al. ( 2017 ) . Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy . Anesthesiology vol. 126 , ( 1 ) 115 - 127 .
Chen J, Kieswich JE, Chiazza F, Moyes AJ, Gobbetti T, Purvis GSD, Salvatori DCF, Patel NSA et al. ( 2017 ) . IκB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD . Journal of the American Society of Nephrology : JASN vol. 28 , ( 1 ) 94 - 105 .
Martin L, Horst K, Chiazza F, Oggero S, Collino M, Brandenburg K, Hildebrand F, Marx G et al. ( 2016 ) . The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis . Scientific Reports vol. 6 ,
Yamada N, Martin L, Sordi R, Brandenburg K, Schuerholz T, Thiemermann C ( 2016 ) . A NOVEL SYNTHETIC PEPTIDE PROTECTS AGAINST ORGAN INJURY IN A RAT-MODEL OF SEVERE HAEMORRHAGIC SHOCK . vol. 46 , is. 4 , pp. 34 - 35 .
Chen J, Hamers AJP, Finsterbusch M, Thiemermann C, Ahluwalia A ( 2016 ) . ACTIVATION OF TRPV1 BY 12(S)-HPETE AND 20-HETE RELEASES CGRP AND PROTECTS THE HEART AGAINST THE CARDIAC DYSFUNCTION CAUSED BY LPS . SHOCK . Conference: Exp Biology 2016 vol. 46 , 31 - 32 .
Martin LB, Zechendorf E, Chen J, Brandenburg K, Marx G, Thiemermann C, Schuerholz T ( 2016 ) . THE SYNTHETIC ANTIMICROBIAL PEPTIDE 19-2.5 ATTENUATES SEPTIC CARDIOMYOPATHY IN A MURINE MODEL OF POLYMICROBIAL SEPSIS . SHOCK . Conference: Japanese Shock Society vol. 46 , 31 - 31 .
Asfar P, Thiemermann C, Radermacher P ( 2016 ) . Norepinephrine, the Intensivist's Swiss Army Knife for Circulatory Shock? . Shock vol. 46 , ( 1 ) 106 - 107 .
Coldewey SM, Benetti E, Collino M, Pfeilschifter J, Sponholz C, Bauer M, Huwiler A, Thiemermann C ( 2016 ) . Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis . Scientific Reports vol. 6 , 27594 - 27594 .
Chen J, Thiemermann C ( 2016 ) . Selenium and niacin for sepsis therapy: The sum is greater than its parts . Critical Care Medicine vol. 44 , ( 6 ) 1256 - 1257 .
Sordi R, Chiazza F, Collino M, Assreuy J, Thiemermann C ( 2016 ) . Neuronal Nitric Oxide Synthase is Involved in Vascular Hyporeactivity and Multiple Organ Dysfunction Associated with Hemorrhagic Shock . SHOCK vol. 45 , ( 5 ) 525 - 533 .
Gaffney VJ, Mota-Filipe H, Pinto RA, Thiemermann C, Loureiro M, Cardoso VV, Benoliel MJ, Almeida CM ( 2016 ) . Chemical and biochemical characterization and in vivo safety evaluation of pharmaceuticals in drinking water . Environmental toxicology and chemistry / SETAC
Chen J, Hamers AJP, Finsterbusch M, Thiemermann C, Ahluwalia A ( 2016 ) . Activation of TRPV1 by 12(s)-HpETE and 20-HETE Releases CGRP and Protects the Heart Against the Cardiac Dysfunction Caused by LPS . FASEB JOURNAL . Conference: Exp Biology (FASEB) 2016 vol. 30 ,
Sordi R, Nandra KK, Chiazza F, Johnson FL, Cabrera CP, Torrance HD, Yamada N, Patel NSA et al. ( 2016 ) . Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation . Annals of surgery
Sordi R, Nandra KK, Chiazza F, Johnson FL, Cabrera CP, Torrance HD, Yamada N, Patel NSA et al. ( 2016 ) . Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation . Ann Surg
Coldewey SM, Benetti E, Collino M, Bauer M, Huwiler A, Thiemermann C ( 2015 ) . Enhanced sphingosine-1-phosphate levels ameliorate murine septic cardiomyopathy . Intensive Care Med Exp vol. 3 , ( Suppl 1 )
Madalli S, Beyrau M, Whiteford J, Duchene J, Nandhra IS, Patel NSA, Motwani MP, Gilroy DW et al. ( 2015 ) . Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states . Biology of Sex Differences vol. 6 , ( 1 )
Chiazza F, Couturier-Maillard A, Benetti E, Mastrocola R, Nigro D, Cutrin JC, Serpe L, Aragno M et al. ( 2015 ) . Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice . Molecular Medicine vol. 21 , 1025 - 1037 .
Coldewey SM, Benetti E, Collino M, Bauer M, Huwiler A, Thiemermann C ( 2015 ) . ENHANCED SPHINGOSINE-1-PHOSPHATE LEVELS ATTENUATE CARDIAC DYSFUNCTION IN EXPERIMENTAL SEPTIC CARDIOMYOPATHY . SHOCK . vol. 44 , 17 - 17 .
Wall JM, Tremoleda JL, Thiemermann C, Brohi K ( 2015 ) . HEART FATTY ACID BINDING PROTEIN (H-FABP) IS A BIOMARKER OF TRAUMA-INDUCED SECONDARY CARDIAC INJURY IN A PRE-CLINICAL MODEL OF TRAUMA-HAEMORRHAGE . SHOCK . vol. 44 , 21 - 22 .
Chen J, Kieswich J, Chiazza F, Gobbetti T, Patel NSA, Perretti M, Collino M, Yaqoob MM et al. ( 2015 ) . THE CARDIAC DYSFUNCTION CAUSED BY SEPSIS IN ANIMALS WITH CHRONIC KIDNEY DISEASE IS ATTENUATED BY INHIBITING I kappa B KINASE . SHOCK . vol. 44 , 16 - 16 .
Johnson F, Patel N, Collino M, Bennetti E, Thiemermann C ( 2015 ) . THE LATE INHIBITION OF INHIBITOR OF IKB KINASE ATTENUATES ACUTE KIDNEY INJURY AND THE SUBSEQUENT DEVELOPMENT OF FIBROSIS IN A RAT MODEL OF ISCHAEMIA REPERFUSION INJURY . SHOCK . vol. 44 , 10 - 10 .
Sordi R, Nandra KK, Chiazza F, Patel NSA, Brohi K, Collino M, Thiemermann C ( 2015 ) . TRAUMA ORGAN PROTECTION WITH ARTESUNATE (TOP-ART): PRECLINICAL EFFICACY OF AN ANTIMALARIAL DRUG WITH EXCELLENT SAFETY PROFILE AND PLANNED PHASE II RCT . SHOCK . vol. 44 , 1 - 1 .
Hache G, Osuchowski M, Thiemermann C ( 2015 ) . Does Insulin Protect the Brain in Mice and Man with Sepsis? . Shock vol. 44 , ( 3 )
Sordi R, Chiazza F, Johnson FL, Patel NSA, Brohi K, Collino M, Thiemermann C ( 2015 ) . Inhibition of IκB kinase attenuates the organ injury and dysfunction associated with hemorrhagic shock . Molecular Medicine vol. 21 , 563 - 575 .
Chen J, Kieswich J, Chiazza F, Gobbetti T, Patel NS, Perretti M, Collino M, Yaqoob MM et al. ( 2015 ) . THE CARDIAC DYSFUNCTION CAUSED BY SEPSIS IN ANIMALS WITH CHRONIC KIDNEY DISEASE IS ATTENUATED BY INHIBITING I kappa B KINASE . SHOCK . vol. 43 , 92 - 93 .
Collino M, Thiemermann C, Cerami A, Brines M ( 2015 ) . Flipping the molecular switch for innate protection and repair of tissues: Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin . Pharmacology and Therapeutics vol. 151 , 32 - 40 .
Lilley E, Armstrong R, Clark N, Gray P, Hawkins P, Mason K, López-Salesansky N, Stark AK et al. ( 2015 ) . Refinement of animal models of sepsis and septic shock . Shock vol. 43 , ( 4 ) 304 - 316 .
Sordi R, Chiazza F, Patel NSA, Doyle RA, Collino M, Thiemermann C ( 2015 ) . 'Preconditioning' with low dose lipopolysaccharide aggravates the organ injury/dysfunction caused by hemorrhagic shock in rats . PLoS ONE vol. 10 , ( 4 )
Sand CA, Starr A, Wilder CDE, Rudyk O, Spina D, Thiemermann C, Treacher DF, Nandi M ( 2015 ) . Quantification of microcirculatory blood flow: A sensitive and clinically relevant prognostic marker in murine models of sepsis . Journal of Applied Physiology vol. 118 , ( 3 ) 344 - 354 .
Gobbetti T, Coldewey SM, Chen J, McArthur S, Le Faouder P, Cenac N, Flower RJ, Thiemermann C et al. ( 2014 ) . Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis . Proceedings of the National Academy of Sciences of the United States of America vol. 111 , ( 52 ) 18685 - 18690 .
McCafferty K, Forbes S, Thiemermann C, Yaqoob MM ( 2014 ) . The challenge of translating ischemic conditioning from animal models to humans: The role of comorbidities . DMM Disease Models and Mechanisms vol. 7 , ( 12 ) 1321 - 1333 .
Roesner JP, Thiemermann C ( 2014 ) . Mirror, mirror on the wall, is off-pump better than on-pump at all? . Shock vol. 42 , ( 2 ) 174 - 175 .
Guerreiro M, Tremoleda JL, Frith D, Thiemermann C, Brohi K ( 2014 ) . Reduction of the natural Activated protein C pathway activity significantly prevents coagulopathy in a murine model of acute traumatic coagulopathy . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine vol. 22 , ( 1 )
Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S et al. ( 2014 ) . Abandon the mouse research ship? Not just yet! . Shock vol. 41 , ( 6 ) 463 - 475 .
Osuchowski MF, Radermacher P, Thiemermann C ( 2014 ) . Caught between a rock and a hard place: seeking an optimal resuscitation strategy for hemorrhaging patients with lung injury . Shock vol. 41 , ( 6 ) 556 - 557 .
Chen J, Chiazza F, Collino M, Coldewey SM, Patel NS, Thiemermann C ( 2014 ) . GENDER DIMORPHISM OF THE CARDIAC DYSFUNCTION IN SEPSIS . SHOCK . vol. 41 , 35 - 35 .
Chen J, Kieswich J, Yaqoob MM, Thiemermann C ( 2014 ) . PRE-EXISTING CHRONIC KIDNEY DISEASE WORSENS MYOCARDIAL DYSFUNCTION CAUSED BY SEPSIS IN MICE . SHOCK . vol. 41 , 40 - 41 .
Guerreiro ML, Tremoleda JL, Thiemermann C, Brohi K ( 2014 ) . REDUCTION OF NATURAL ACTIVATED PROTEIN C PREVENTS COAGULOPATHY IN A PRECLINICAL ANIMAL MODEL OF ACUTE TRAUMATIC COAGULOPATHY . SHOCK . vol. 41 , 51 - 51 .
Radermacher P, Huber-Lang M, Knippschild U, Thiemermann C ( 2014 ) . The obesity paradox revisited: does increased body mass protect against circulatory shock? . Shock vol. 41 , ( 6 ) 554 - 555 .
Coldewey SM, Thiemermann C ( 2014 ) . PLEIOTROPIC EFFECTS OF ATORVASTATIN IN EXPERIMENTAL SEPSIS: PRESERVATION OF beta(1)-ADRENORECEPTOR SIGNALING IN THE HEART . SHOCK vol. 41 , ( 5 ) 458 - 459 .
Chapagain A, Caton PW, Kieswich J, Andrikopoulos P, Nayuni N, Long JH, Harwood SM, Webster SP et al. ( 2014 ) . Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia . Proc Natl Acad Sci U S A vol. 111 , ( 10 ) 3817 - 3822 .
Jellestad L, Fink T, Pradarutti S, Kubulus D, Wolf B, Bauer I, Thiemermann C, Rensing H ( 2014 ) . Inhibition of glycogen synthase kinase (GSK)-3-β improves liver microcirculation and hepatocellular function after hemorrhagic shock . Eur J Pharmacol vol. 724 , 175 - 184 .
Collino M, Benetti E, Rogazzo M, Chiazza F, Mastrocola R, Nigro D, Cutrin JC, Aragno M et al. ( 2014 ) . A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice . British Journal of Pharmacology vol. 171 , ( 24 ) 5802 - 5815 .
Chen J, Chiazza F, Collino M, Patel NSA, Coldewey SM, Thiemermann C ( 2014 ) . Gender dimorphism of the cardiac dysfunction in murine sepsis: signalling mechanisms and age-dependency . PLoS One vol. 9 , ( 6 )
Clemens MG, Radermacher P, Thiemermann C ( 2014 ) . Nutritional support in critically ill patients: enteral, parenteral, or not at all? . Shock vol. 41 , ( 1 ) 87 - 88 .
McCafferty K, Byrne CJ, Kieswich J, Raftery M, Thiemermann C, Yaqoob MM ( 2014 ) . The effect of uraemia on the duration of arrhythmias in the context of cardioprotective ischaemic conditioning strategies . Heart Asia vol. 6 , ( 1 ) 76 - 82 .
Wepler M, Hafner S, Scheuerle A, Reize M, Gröger M, Wagner F, Simon F, Matallo J et al. ( 2013 ) . Effects of the PPAR-β/δ agonist GW0742 during resuscitated porcine septic shock . Intensive Care Medicine Experimental vol. 1 , ( 1 )
Hafner S, Wepler M, McCook O, Scheuerle A, Wagner F, Matallo J, Chen J, Calzia E et al. ( 2013 ) . EFFECTS OF THE PPAR-beta/delta AGONIST GW0742 ON RENAL INFLAMMATION AND KIDNEY TISSUE INJURY DURING RESUSCITATED PORCINE SEPTIC SHOCK . SHOCK . vol. 40 , 24 - 24 .
Coldewey SM, Khan AI, Kapoor A, Collino M, Rogazzo M, Brines M, Cerami A, Hall P et al. ( 2013 ) . Erythropoietin attenuates acute kidney dysfunction in murine experimental sepsis by activation of the β-common receptor . Kidney Int vol. 84 , ( 3 ) 482 - 490 .
Rocha J, Barateiro A, Fernandes A, Raposo J, Direito R, Eduardo-Figueira M, Pinto R, Thiemermann C et al. ( 2013 ) . GLYCOGEN SYNTHASE KINASE-3 INHIBITION REDUCES LIVER, NEUROMUSCULAR, AND LUNG INJURY CAUSED BY BURN INJURY IN THE RAT . SHOCK . vol. 40 , 27 - 27 .
Coldewey SM, Collino M, Rogazzo M, Patel NSA, Thiemermann C ( 2013 ) . INHIBITION OF I kappa B KINASE-A NOVEL THERAPEUTIC APPROACH IN EXPERIMENTAL SEPSIS . SHOCK . vol. 40 , 16 - 16 .
Khan AI, Coldewey SM, Patel NSA, Rogazzo M, Collino M, Yagoob MM, Radermacher P, Kapoor A et al. ( 2013 ) . Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the beta-common receptor . DISEASE MODELS & MECHANISMS vol. 6 , ( 4 ) 1021 - 1030 .
Coldewey SM, Rogazzo M, Collino M, Patel NSA, Thiemermann C ( 2013 ) . Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse . Dis Model Mech vol. 6 , ( 4 ) 1031 - 1042 .
Radermacher P, van Griensven M, Thiemermann C ( 2013 ) . Humane end points in experimental models of septic shock: a must, not a superfluous nightmare for researchers! . Shock vol. 39 , ( 6 ) 541 - 542 .
Radermacher P, Thiemermann C ( 2013 ) . Receptor-selective vasopressin analogs: a new push for "decatecholaminization"? . Shock vol. 39 , ( 6 ) 539 - 540 .
Khan AI, Coldewey SM, Patel NS, Rogazzo M, Collino M, Yaqoob MM, Radermacher P, Kapoor A et al. ( 2013 ) . 233 ERYTHROPOIETIN ATTENUATES CARDIAC DYSFUNCTION IN EXPERIMENTAL SEPSIS VIA ACTIVATION OF THE Β-COMMON RECEPTOR . Heart . vol. 99 ,
Nandra KK, Collino M, Rogazzo M, Fantozzi R, Patel NSA, Thiemermann C ( 2013 ) . Pharmacological preconditioning with erythropoietin attenuates the organ injury and dysfunction induced in a rat model of hemorrhagic shock . Dis Model Mech vol. 6 , ( 3 ) 701 - 709 .
Radermacher P, Huber-Lang M, Thiemermann C ( 2013 ) . Catecholamines and the septic heart: opening Pandora's box? . Shock vol. 39 , ( 4 ) 404 - 405 .
Bangash MN, Patel NSA, Benetti E, Collino M, Hinds CJ, Thiemermann C, Pearse RM ( 2013 ) . Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow . Crit Care vol. 17 , ( 2 )
Shintani Y, Kapoor A, Kaneko M, Smolenski RT, D'Acquisto F, Coppen SR, Harada-Shoji N, Lee HJ et al. ( 2013 ) . TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons . Proc Natl Acad Sci U S A vol. 110 , ( 13 ) 5109 - 5114 .
Barry SP, Ounzain S, McCormick J, Scarabelli TM, Chen-Scarabelli C, Saravolatz LII, Faggian G, Mazzucco A et al. ( 2013 ) . Enhanced IL-17 signalling following myocardial ischaemia/reperfusion injury (Retracted article. See vol. 274, pg. 404, 2019) . INTERNATIONAL JOURNAL OF CARDIOLOGY vol. 163 , ( 3 ) 326 - 334 .
Collino M, Benetti E, Rogazzo M, Mastrocola R, Yaqoob MM, Aragno M, Thiemermann C, Fantozzi R ( 2013 ) . Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-delta agonism correlates with impaired NLRP3 inflammasome activation . BIOCHEMICAL PHARMACOLOGY vol. 85 , ( 2 ) 257 - 264 .
Calzia E, Huber-Lang M, Ignatius A, Radermacher P, Thiemermann C ( 2012 ) . MODELING TRAUMATIC-HEMORRHAGIC SHOCK-NOTHING IS SIMPLE AND EASY . SHOCK vol. 38 , ( 6 ) 685 - 686 .
McCafferty K, Byrne CJ, Kieswich J, Harwood S, Andrikopoulos P, Raftery M, Thiemermann C, Yaqoob MM ( 2012 ) . Response to letter regarding article, "ischemic conditioning protects the uremic heart in a rodent model of myocardial infarction" . Circulation vol. 126 , ( 13 )
Patel NSA, Nandra KK, Thiemermann C ( 2012 ) . Bench-to-bedside review: Erythropoietin and its derivatives as therapies in critical care . Crit Care vol. 16 , ( 4 )
Nandra KK, Takahashi K, Collino M, Benetti E, Wong WSF, Goh FY, Suzuki K, Patel NSA et al. ( 2012 ) . Acute treatment with bone marrow-derived mononuclear cells attenuates the organ injury/dysfunction induced by hemorrhagic shock in the rat . Shock vol. 37 , ( 6 ) 592 - 598 .
Patel NSA, Kerr-Peterson HL, Brines M, Collino M, Rogazzo M, Fantozzi R, Wood EG, Johnson FL et al. ( 2012 ) . Delayed administration of pyroglutamate helix B surface peptide (pHBSP), a novel nonerythropoietic analog of erythropoietin, attenuates acute kidney injury . Mol Med vol. 18 , 719 - 727 .
Byrne CJ, McCafferty K, Kieswich J, Harwood S, Andrikopoulos P, Raftery M, Thiemermann C, Yaqoob MM ( 2012 ) . Ischemic conditioning protects the uremic heart in a rodent model of myocardial infarction . Circulation vol. 125 , ( 10 ) 1256 - 1265 .
Bracht H, Simon F, Matallo J, Gröger M, McCook O, Seifritz A, Georgieff M, Calzia E et al. ( 2012 ) . Reduced expression of PPAR-β/δ limits the potential beneficial effects of GW0742 during septic shock in atherosclerotic swine . Critical Care vol. 16 , ( Suppl 1 )
Khan AI, Coldewey SM, Kapoor A, Patel NS, Thiemermann C, Rogazzo M, Collino M ( 2012 ) . ERYTHROPOIETIN ATTENUATES CARDIAC DYSFUNCTION IN EXPERIMENTAL SEPSIS VIA ACTIVATION OF THE BETA-COMMON RECEPTOR . SHOCK . vol. 37 , 55 - 56 .
Coldewey SM, Khan AI, Rogazzo M, Collino M, Kapoor A, Patel NS, Thiemermann C ( 2012 ) . ERYTHROPOIETIN REDUCES THE ACUTE KIDNEY INJURY IN EXPERIMENTAL SEPSIS VIA ACTIVATION OF THE beta ETA-COMMON RECEPTOR . SHOCK . vol. 37 , 52 - 52 .
Frith D, Guerreiro M, Pearse R, Thiemermann C, Brohi K ( 2012 ) . EXPERIMENTAL ACUTE TRAUMATIC COAGULOPATHY IS ASSOCIATED WITH MODERATE IMPAIRMENT OF THROMBIN GENERATION AND DYSFIBRINOGENEMIA . SHOCK . vol. 37 , 34 - 34 .
McCook O, Georgieff M, Scheuerle A, Moeller P, Thiemermann C, Radermacher P ( 2012 ) . Erythropoietin in the critically ill: do we ask the right questions? . CRITICAL CARE vol. 16 , ( 5 ) Article ARTN 319 ,
Duvigneau J, Patel NS, Kerr-Peterson H, Paier-Pourani J, Muellebner A, Weidinger A, Redl H, Thiemermann C et al. ( 2012 ) . REMOTE EFFECTS OF KIDNEY ISCHEMIA/REPERFUSION INJURY ON THE LIVER INVOLVES ENDOPLASMIC RETICULUM STRESS . SHOCK . vol. 37 , 119 - 119 .
Nandra KK, Patel NS, Harwood S, Collino M, Rogazzo M, Yaqoob M, Thiemermann C ( 2012 ) . THREE DAY PRE-TREATMENT WITH ERYTHROPOIETIN ATTENUATES THE ORGAN INJURY AND DYSFUNCTION INDUCED BY HEMORRHAGIC SHOCK IN THE RAT BY A MECHANISM INDEPENDENT OF ENDOTHELIAL PROGENITOR CELL MOBILISATION . SHOCK . vol. 37 , 96 - 97 .
Manson J, Thiemermann C, Brohi K ( 2012 ) . Trauma alarmins as activators of damage-induced inflammation . Br J Surg vol. 99 Suppl 1 , 12 - 20 .
Shintani Y, Kapoor A, Drexler H, Terracciano C, Smolenski R, Kaneko M, Harada N, Coppen S et al. ( 2011 ) . A Novel Toll-Like Receptor 9 Signaling in Cardiomyocytes . CIRCULATION vol. 124 , ( 21 )
Madalli S, Bauer M, Thiemermann C, Nourshargh S, Scotland R ( 2011 ) . Differential Regulation of Neutrophil Mobilization and Integrin Expression in Females Protects Against Ischemia/Reperfusion-Induced Local and Remote Tissue Injury . CIRCULATION vol. 124 , ( 21 )
Patel NS, Collino M, Yaqoob MM, Thiemermann C ( 2011 ) . Erythropoietin in the intensive care unit: beyond treatment of anemia . Ann Intensive Care vol. 1 ,
Patel NSA, Nandra KK, Brines M, Collino M, Wong WF, Kapoor A, Benetti E, Goh FY et al. ( 2011 ) . A nonerythropoietic peptide that mimics the 3D structure of erythropoietin reduces organ injury/dysfunction and inflammation in experimental hemorrhagic shock . Mol Med vol. 17 , ( 9-10 ) 883 - 892 .
Wang YY, Ryg U, Dahle MK, Steffensen KR, Thiemermann C, Chaudry IH, Reinholt FP, Collins JL et al. ( 2011 ) . Liver X Receptor Protects against Liver Injury in Sepsis Caused by Rodent Cecal Ligation and Puncture . SURG INFECT vol. 12 , ( 4 ) 283 - 289 .
Frith D, Baptista ML, Cohen M, Pearse R, Thiemermann C, Brohi K ( 2011 ) . Experimental acute traumatic coagulopathy is due to systemic activation of protein c during hypoperfusion . JOURNAL OF THROMBOSIS AND HAEMOSTASIS vol. 9 , 481 - 481 .
Manson J, Davenport R, Coates A, Rourke C, De'Ath HD, Raza I, Spoors C, Khan S et al. ( 2011 ) . TRAUMATIC TISSUE DAMAGE: THE SEARCH FOR TRAUMA ALARMINS . INFLAMMATION RESEARCH . vol. 60 , 160 - 160 .
Maio R, Sepodes B, Patel NSA, Thiemermann C, Mota-Filipe H, Costa P ( 2011 ) . Erythropoietin preserves the integrity and quality of organs for transplantation after cardiac death . Shock vol. 35 , ( 2 ) 126 - 133 .
Kapoor A, Thiemermann C ( 2011 ) . Niacin as a novel therapy for septic shock? . Crit Care Med vol. 39 , ( 2 ) 410 - 411 .
Collino M, Benetti E, Miglio G, Castiglia S, Rosa AC, Aragno M, Thiemermann C, Fantozzi R ( 2011 ) . Peroxisome proliferator-activated receptor beta/delta agonism protects the kidney against ischemia/reperfusion injury in diabetic rats . FREE RADICAL BIO MED vol. 50 , ( 2 ) 345 - 353 .
Kapoor A, Thiemermann C ( 2011 ) . Targeting CCR2 A Novel Therapeutic Strategy for Septic Shock? . AM J RESP CRIT CARE vol. 183 , ( 2 ) 150 - 151 .
Kapoor A, Shintani Y, Collino M, Osuchowski MF, Busch D, Patel NSA, Sepodes B, Castiglia S et al. ( 2011 ) . BENEFICIAL ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-BETA/DELTA IN SEPTIC SHOCK . SHOCK . vol. 36 , 20 - 20 .
Nandra K, Takahashi K, Collino M, Benetti E, Wong WSF, Goh FY, Salem H, Suzuki K et al. ( 2011 ) . BONE-MARROW DERIVED MONONUCLEAR CELLS PROTECT AGAINST MULTIPLE ORGAN FAILURE IN HEMORRHAGIC SHOCK THROUGH AN AKT DEPENDANT PATHWAY . SHOCK vol. 36 , 26 - 26 .
Busch D, Kapoor A, Khadem A, Redl H, Thiemermann C, Bahrami S, Osuchowski MF ( 2011 ) . DELAYED ACTIVATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)-BETA/DELTA IMPROVES LONG-TERM SURVIVAL IN THE MOUSE MODEL OF POLYMICROBIAL SEPSIS . SHOCK vol. 36 , 10 - 10 .
Frith D, Baptista ML, Cohen MJ, Pearse R, Thiemermann C, Brohi K ( 2011 ) . EXPERIMENTAL ACUTE TRAUMATIC COAGULOPATHY: INITIATED BY HYPOPERFUSION, MODULATED BY THE PROTEIN C PATHWAY . SHOCK vol. 36 , 16 - 17 .
Maio R, Sepodes B, Thiemermann C, Mota-Filipe H ( 2011 ) . OPPORTUNITIES TO ENHANCE ORGAN VIABILITY . SHOCK vol. 36 , 3 - 3 .
Kapoor A, Shintani Y, Collino M, Osuchowski MF, Busch D, Patel NSA, Sepodes B, Castiglia S et al. ( 2010 ) . Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock . Am J Respir Crit Care Med vol. 182 , ( 12 ) 1506 - 1515 .
Frith D, Stanworth S, Gaarder C, Maegele M, Goslings C, Johansson P, Allard S, Cohen M et al. ( 2010 ) . Acute traumatic coagulopathy is dependent upon injury load and shock . BRITISH JOURNAL OF SURGERY vol. 97 , 39 - 40 .
Lovell MJ, Yasin M, Lee KL, Cheung KK, Shintani Y, Collino M, Sivarajah A, Leung K-Y et al. ( 2010 ) . Bone marrow mononuclear cells reduce myocardial reperfusion injury by activating the PI3K/Akt survival pathway . Atherosclerosis vol. 213 , ( 1 ) 67 - 76 .
Galuppo M, Di Paola R, Mazzon E, Esposito E, Paterniti I, Kapoor A, Thiemermann C, Cuzzocrea S ( 2010 ) . GW0742, a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice . Int J Immunopathol Pharmacol vol. 23 , ( 4 ) 1033 - 1046 .
Frith D, Goslings JC, Gaarder C, Maegele M, Cohen MJ, Allard S, Johansson PI, Stanworth S et al. ( 2010 ) . Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations . J Thromb Haemost vol. 8 , ( 9 ) 1919 - 1925 .
Kapoor A, Collino M, Castiglia S, Fantozzi R, Thiemermann C ( 2010 ) . Activation of peroxisome proliferator-activated receptor-beta/delta attenuates myocardial ischemia/reperfusion injury in the rat . Shock vol. 34 , ( 2 ) 117 - 124 .
Barry SP, Lawrence KM, McCormick J, Soond SM, Hubank M, Eaton S, Sivarajah A, Scarabelli TM et al. ( 2010 ) . New targets of urocortin-mediated cardioprotection . J Mol Endocrinol vol. 45 , ( 2 ) 69 - 85 .
Collino M, Aragno M, Castiglia S, Miglio G, Tomasinelli C, Boccuzzi G, Thiemermann C, Fantozzi R ( 2010 ) . Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation . BRIT J PHARMACOL vol. 160 , ( 8 ) 1892 - 1902 .
Ghezzi P, Bernaudin M, Bianchi R, Blomgren K, Brines M, Campana W, Cavaletti G, Cerami A et al. ( 2010 ) . Erythropoietin: not just about erythropoiesis . Lancet vol. 375 , ( 9732 )
Rehberg S, Thiemermann C, Traber DL ( 2010 ) . Increased inotropism following PARP inhibition in the setting of myocardial reperfusion injury: another piece in the jigsaw? . Shock vol. 33 , ( 6 ) 668 - 669 .
Paterniti I, Esposito E, Mazzon E, Galuppo M, Di Paola R, Bramanti P, Kapoor A, Thiemermann C et al. ( 2010 ) . Evidence for the Role of Peroxisome Proliferator-Activated Receptor-beta/delta in the Development of Spinal Cord Injury . J PHARMACOL EXP THER vol. 333 , ( 2 ) 465 - 477 .
Rehberg S, Thiemermann C, Maybauer MO ( 2010 ) . Role of chelatable iron versus myoglobin in oxidative stress after crush trauma . Shock vol. 33 , ( 5 ) 552 - 553 .
Esposito E, Paterniti I, Mazzon E, Genovese T, Galuppo M, Di Paola R, Bramanti P, Kapoor A et al. ( 2010 ) . Evidence for the role of PPAR-beta/delta in the development of spinal cord injury . FASEB JOURNAL vol. 24 ,
Di Paola R, Crisafulli C, Mazzon E, Esposito E, Paterniti I, Galuppo M, Genovese T, Thiemermann C et al. ( 2010 ) . GW0742, A HIGH-AFFINITY PPAR-beta/delta AGONIST, INHIBITS ACUTE LUNG INJURY IN MICE . SHOCK vol. 33 , ( 4 ) 426 - 435 .
Salem HK, Thiemermann C ( 2010 ) . Mesenchymal stromal cells: current understanding and clinical status . Stem Cells vol. 28 , ( 3 ) 585 - 596 .
Galuppo M, Di Paola R, Mazzon E, Genovese T, Crisafulli C, Paterniti I, Cuzzocrea E, Bramanti P et al. ( 2010 ) . Role of PPAR-delta in the development of zymosan-induced multiple organ failure: an experiment mice study . J INFLAMM-LOND vol. 7 , Article 12 ,
Milsom AB, Patel NSA, Mazzon E, Tripatara P, Storey A, Mota-Filipe H, Sepodes B, Webb AJ et al. ( 2010 ) . Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice . NITRIC OXIDE-BIOL CH vol. 22 , ( 2 ) 141 - 148 .
Kapoor A, Shintani Y, Collino M, Bailey LK, Patel NSA, Sepodes B, Tripatara P, Castiglia S et al. ( 2010 ) . 027 Protective role of peroxisome proliferator-activated receptor Î/Î′ in cardiac dysfunction and organ injury/inflammation caused by endotoxin in mice . Heart vol. 96 , ( 4 )
Kapoor A, Thiemermann C ( 2010 ) . Hydrogen sulfide, neurogenic inflammation, and cardioprotection: A tale of rotten eggs and vanilloid receptors . CRIT CARE MED vol. 38 , ( 2 ) 728 - 730 .
Frith D, Cohen M, Pearse R, Thiemermann C, Brohi K ( 2010 ) . Rodent coagulation responses to trauma and haemorrhagic shock . INFLAMMATION RESEARCH . vol. 59 , S26 - S27 .
Patel NSA, Yaqoob MM, Thiemermann C ( 2010 ) . Tissue Protective Activities of Erythropoietin . Yearbook of Intensive Care and Emergency Medicine 2010 , vol. 2010 ,
Kumar S, Allen DA, Kieswich JE, Patel NSA, Harwood S, Mazzon E, Cuzzocrea S, Raftery MJ et al. ( 2009 ) . Dexamethasone ameliorates renal ischemia-reperfusion injury . J Am Soc Nephrol vol. 20 , ( 11 ) 2412 - 2425 .
Wang YY, Dahle MK, Steffensen KR, Reinholt FP, Collins JL, Thiemermann C, Aasen AO, Gustafsson J-A et al. ( 2009 ) . Liver X receptor agonist GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages . Shock vol. 32 , ( 5 ) 548 - 553 .
Scheiermann C, Colom B, Meda P, Patel NSA, Voisin M-B, Marrelli A, Woodfin A, Pitzalis C et al. ( 2009 ) . Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury . Arterioscler Thromb Vasc Biol vol. 29 , ( 10 ) 1509 - 1515 .
Maio R, Figueiredo N, Santos I, Thiemermann C, Mota-Filipe H, Costa P ( 2009 ) . STRATEGIES TO IMPROVE THE QUALITY OF ORGANS FROM DCD . TRANSPL INT vol. 22 , 43 - 43 .
Milsom A, Patel N, Storey A, Cuzzocrea S, Mazzon E, Webb A, Hobbs A, Thiemermann C et al. ( 2009 ) . Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischaemia-reperfusion injury in mice . NITRIC OXIDE-BIOLOGY AND CHEMISTRY . vol. 20 , S39 - S40 .
Bianca RDD, Sorrentino R, Mitidieri E, Marzocco S, Autore G, Thiemermann C, Pinto A, Sorrentino R ( 2009 ) . RECOMBINANT HUMAN ERYTHROPOIETIN PREVENTS LIPOPOLYSACCHARIDE-INDUCED VASCULAR HYPOREACTIVITY IN THE RAT . SHOCK vol. 31 , ( 5 ) 529 - 534 .
di Villa Bianca RD, Sorrentino R, Mitidieri E, Marzocco S, Autore G, Thiemermann C, Pinto A, Sorrentino R ( 2009 ) . Recombinant human erythropoietin prevents lipopolysaccharide-induced vascular hyporeactivity in the rat . Shock vol. 31 , ( 5 ) 529 - 534 .
Ozuna H, Burke D, Wylie M, Ozuna-Vazquez H ( 2009 ) . Alternative mRNA splicing of RAD5 on mouse tissues . FASEB JOURNAL vol. 23 ,
Genilo EJ, Dutta S, Keating A ( 2009 ) . Determining specificities and affinities between BH3 peptides and BcL-2 proteins using yeast surface display . FASEB JOURNAL vol. 23 ,
Colom B, Scheiermann C, Woodfin A, Meda P, Patel N, Marrelli A, Pitzalis C, Thiemermann C et al. ( 2009 ) . Effect of soluble JAM-C on leukocyte transmigration in models of ischemia/reperfusion injury . FASEB JOURNAL vol. 23 ,
Sepodes BM, Rocha JP, Eduardo-Figueira M, Thiemermann C, Mota-Filipe H ( 2009 ) . Effects of Glycogen Synthase Kinase-beta Inhibition in Ischemia-Reperfusion Injury of the Liver . FASEB JOURNAL vol. 23 ,
Tripatara P, Patel NSA, Brancaleone V, Renshaw D, Rocha J, Sepodes B, Mota-Filipe H, Perretti M et al. ( 2009 ) . Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study . Eur J Pharmacol vol. 606 , ( 1-3 ) 205 - 209 .
Sivarajah A, Collino M, Yasin M, Benetti E, Gallicchio M, Mazzon E, Cuzzocrea S, Fantozzi R et al. ( 2009 ) . Anti-apoptotic and anti-inflammatory effects of hydrogen sulfide in a rat model of regional myocardial I/R . Shock vol. 31 , ( 3 ) 267 - 274 .
Patel NSA, di Paola R, Mazzon E, Britti D, Thiemermann C, Cuzzocrea S ( 2009 ) . Peroxisome proliferator-activated receptor-alpha contributes to the resolution of inflammation after renal ischemia/reperfusion injury . J Pharmacol Exp Ther vol. 328 , ( 2 ) 635 - 643 .
Patel NSA, Brines M, Sepodes B, Brown PAJ, Stewart KN, Mota-Filipe H, Cerami A, Thiemermann C ( 2009 ) . A TISSUE PROTECTIVE, BUT NON-HAEMATOPOIETIC, ANALOGUE OF ERYTHROPOIETIN FOR THE TREATMENT OF ACUTE KIDNEY INJURY . SHOCK . vol. 32 , 5 - 5 .
Kapoor A, Collino M, Castiglia S, Fantozzi R, Thiemermann C ( 2009 ) . ACTIVATION OF PPAR-beta/delta ATTENUATES MYOCARDIAL ISCHEMIA/REPERFUSION INJURY IN THE RAT . SHOCK . vol. 32 , 23 - 23 .
Frith D, Chesebro B, Pittet JF, Cohen MJ, Thiemermann C, Pearse R, Brohi K ( 2009 ) . ACUTE TRAUMATIC COAGULOPATHY IS DRIVEN BY SYSTEMIC HYPOPERFUSION INDEPENDENT OF HYPOTENSION AND HAEMORRHAGE VOLUME . SHOCK . vol. 32 , 9 - 9 .
Nandra KK, Patel NSA, Thiemermann C ( 2009 ) . DAILY PRETREATMENT WITH ERYTHROPOIETIN ATTENUATES THE TISSUE INJURY CAUSED BY HAEMORRHAGIC SHOCK . SHOCK . vol. 32 , 11 - 11 .
Cuzzoerea S, Galuppo M, Di Paola R, Mazzon E, Genovese T, Crisafulli C, Paterniti I, Kapoor A et al. ( 2009 ) . GW0742, A HIGH AFFINITY PPAR-beta/delta AGONIST REDUCES THE DEVELOPMENT OF ZYMOSAN-INDUCED MULTIPLE ORGAN FAILURE IN MICE . SHOCK . vol. 32 , 13 - 13 .
Collino M, Aragno M, Castiglia S, Tomasinelli C, Thiemermann C, Boccuzzi G, Fantozzi R ( 2009 ) . Insulin Reduces Cerebral Ischemia/Reperfusion Injury in the Hippocampus of Diabetic Rats A Role for Glycogen Synthase Kinase-3 beta . DIABETES vol. 58 , ( 1 ) 235 - 242 .
Kapoor A, Shintani Y, Collino M, Bailey LK, Patel NSA, Sepodes B, Tripatara P, Castiglia S et al. ( 2009 ) . PPAR-B/delta ACTIVATION ATTENUATES ORGAN INJURY/DYSFUNCTION AND INFLAMMATION CAUSED BY ENDOTOXIN . SHOCK . vol. 32 , 7 - 7 .
Maio R, Figueiredo N, Santos I, Sepodes B, Thiemermann C, Mota-Filipe H, Costa P ( 2009 ) . PRE-TREATMENT OF THE DONOR WITH ERYTHROPOIETIN AND TREATMENT OF THE RECIPIENT WITH 5-AIQ IMPROVES THE QUALITY OF ORGANS FROM DONORS AFTER CARDIAC DEATH (DCD), IN EXPERIMENTAL KIDNEY TRANSPLANTATION . SHOCK . vol. 32 , 5 - 5 .
Marques P, Rocha J, Pinto R, Sepodes B, Thiemermann C, Mota-Filipe H ( 2009 ) . THE EFFECT OF LIPOPOLYSACCHARIDE PRECONDITIONING IN AN EXPERIMENTAL MODEL OF BURN INJURY IN THE RAT . SHOCK . vol. 32 , 6 - 6 .
Marques P, Rocha J, Pinto R, Sepodes B, Thiemermann C, Mota-Filipe H ( 2009 ) . THE EFFECT OF SIMVASTATTN PRE-TREATMENT IN AN EXPERIMENTAL MODEL OF BURN INJURY IN THE RAT . SHOCK . vol. 32 , 19 - 19 .
Davenport R, Coates A, Allard S, Pasi J, MacCallum P, Stanworth S, Thiemermann C, Pearse R et al. ( 2009 ) . TRAUMA HAEMORRHAGE: EVOLVING ROLE OF ROTEM FOR PREDICTING TRANSFUSION REQUIREMENTS . SHOCK . vol. 32 , 15 - 15 .
Eltze T, Boer R, Wagner T, Weinbrenner S, McDonald MC, Thiemermann C, Burkle A, Klein T ( 2008 ) . Imidazoquinolinone, Imidazopyridine, and Isoquinolindione Derivatives as Novel and Potent Inhibitors of the Poly(ADP-ribose) Polymerase (PARP): A Comparison with Standard PARP Inhibitors . MOL PHARMACOL vol. 74 , ( 6 ) 1587 - 1598 .
Yasin M, Shintani Y, Collino M, Takahashi K, Salem H, Kapoor A, Rucklidge G, Suzuki K et al. ( 2008 ) . Abstract 1741: Bone Marrow Mononuclear Cell Therapy upon Reperfusion Reduces Myocardial Infarct Size by Activating the PI3K/Akt Survival Pathway . Circulation vol. 118 , ( suppl_18 )
Yasin M, Shintani Y, Collino M, Takahashi K, Salem H, Kapoor A, Rucklidge G, Suzuki K et al. ( 2008 ) . Bone Marrow Mononuclear Cell Therapy upon Reperfusion Reduces Myocardial Infarct Size by Activating the PI3K/Akt Survival Pathway . CIRCULATION . vol. 118 , S380 - S380 .
Dugo L, Collin M, Allen DA, Patel NSA, Bauer I, Mervaala EMA, Louhelainen M, Foster SJ et al. ( 2008 ) . Inhibiting Glycogen Synthase Kinase 3β in Sepsis . Sepsis: New Insights, New Therapies , vol. 280 ,
Tripatara P, Patel NSA, Collino M, Gallicchio M, Kieswich J, Castiglia S, Benetti E, Stewart KN et al. ( 2008 ) . Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunction . Lab Invest vol. 88 , ( 10 ) 1038 - 1048 .
Collino M, Thiemermann C, Mastrocola R, Gallicchio M, Benetti E, Miglio G, Castiglia S, Danni O et al. ( 2008 ) . Treatment with the glycogen synthase kinase-3 beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus . SHOCK vol. 30 , ( 3 ) 299 - 307 .
Thiemermann C ( 2008 ) . What's new in Shock, September 2008? . Shock vol. 30 , ( 3 ) 227 - 230 .
Brines M, Patel NSA, Villa P, Brines C, Mennini T, De Paola M, Erbayraktar Z, Erbayraktar S et al. ( 2008 ) . Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin . P NATL ACAD SCI USA vol. 105 , ( 31 ) 10925 - 10930 .
Todorovic Z, Nesic Z, Stojanovic R, Basta-Jovanovic G, Radojevic-Skodric S, Velickovic R, Chatterjee PK, Thiemermann C et al. ( 2008 ) . Acute protective effects of simvastatin in the rat model of renal ischemia-reperfusion injury: It is never too late for the pretreatment . J PHARMACOL SCI vol. 107 , ( 4 ) 465 - 470 .
Maio R, Figueiredo N, Santos I, Sepodes B, Mota-Filipe H, Thiemermann C, Costa P ( 2008 ) . Strategies to improve the quality of organs from DCD: Pre-treat the donor with erythropoietin and treat the recipient with 5-aminoisoquinolinone . AMERICAN JOURNAL OF TRANSPLANTATION . vol. 8 , 303 - 303 .
Figueiredo N, Maio R, Santos I, Sepodes B, Thiemermann C, Mota-Filipe H, Costa P ( 2008 ) . The effect of 5-aminoisoquinolinone during machine perfusion of kidneys recovered after cardiac death (Experimental study) . AMERICAN JOURNAL OF TRANSPLANTATION . vol. 8 , 498 - 498 .
Myhre AE, Agren J, Dahle MK, Tamburstuen MV, Lyngstadaas SP, Collins AJL, Foster SJ, Thiemermann C et al. ( 2008 ) . Liver X receptor is a key regulator of cytokine release in human monocytes . Shock vol. 29 , ( 4 ) 468 - 474 .
Thiemermann C ( 2008 ) . What's new in Shock, April 2008? . Shock vol. 29 , ( 4 ) 427 - 430 .
Murch O, Abdelrahman M, Kapoor A, Thiemermann C ( 2008 ) . Muramyl dipeptide enhances the response to endotoxin to cause multiple organ injury in the anesthetized rat . Shock vol. 29 , ( 3 ) 388 - 394 .
Thiemermann C ( 2008 ) . What's new in shock, March 2008 . Shock vol. 29 , ( 3 ) 311 - 314 .
Murch O, Abdelrahman M, Collino M, Gallicchio M, Benetti E, Mazzon E, Fantozzi R, Cuzzocrea S et al. ( 2008 ) . Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat . Crit Care Med vol. 36 , ( 2 ) 550 - 559 .
Collino M, Patel NSA, Thiemermann C ( 2008 ) . PPARs as new therapeutic targets for the treatment of cerebral ischemia/reperfusion injury . Therapeutic Advances in Cardiovascular Disease vol. 2 , ( 3 ) 179 - 197 .
Wang JE, Wang YY, Dahle MK, Sandvik A, Steffensen KR, Thiemermann C, Chaudry IH, Gustafsson JA et al. ( 2008 ) . Role of liver X receptor in experimental sepsis . SHOCK . vol. 29 , 101 - 101 .
Frith D, Chesebro B, Patel N, Thiemermann C, Brohi K, Cohen M, Pearse R ( 2008 ) . Towards a mouse model for acute coagulopathy of trauma/shock . SHOCK . vol. 29 , 6 - 6 .
Thiemermann C, Szabó C, Radermacher P, Singer M, Van Den Berghe G, Griffiths RD, Fink MP, Piantadosi CA et al. ( 2007 ) . Discussion . Novartis Foundation Symposium . vol. 280 , 103 - 107 .
Cuzzocrea S, Malleo G, Genovese T, Mazzon E, Esposito E, Muià C, Abdelrahman M, Di Paola R et al. ( 2007 ) . Effects of glycogen synthase kinase-3[beta] inhibition on the development of cerulein-induced acute pancreatitis in mice * . Critical Care Medicine vol. 35 , ( 12 ) 2811 - 2821 .
Thiemermann C, Gilroy D, Singer M, Cohen J, Radermacher P, Fink MP, Marshall JC, Piantadosi CA et al. ( 2007 ) . General discussion I . Novartis Foundation Symposium . vol. 280 , 160 - 164 .
Cuzzocrea S, Malleo G, Genovese T, Mazzon E, Esposito E, Muià C, Abdelrahman M, Di Paola R et al. ( 2007 ) . Effects of glycogen synthase kinase-3beta inhibition on the development of cerulein-induced acute pancreatitis in mice* . Crit Care Med
Ruud TE, Gundersen Y, Wang JE, Foster SJ, Thiemermann C, Aasen AO ( 2007 ) . Activation of cytokine synthesis by systemic infusions of lipopolysaccharide and peptidoglycan in a porcine model in vivo and in vitro . Surg Infect (Larchmt) vol. 8 , ( 5 ) 495 - 503 .
Thiemermann C ( 2007 ) . What's new in shock, October 2007? . SHOCK vol. 28 , ( 4 ) 371 - 374 .
Sexton A, McDonald M, Cayla C, Thiemermann C, Ahluwalia A ( 2007 ) . 12-Lipoxygenase-derived eicosanoids protect against myocardial ischemia/reperfusion injury via activation of neuronal TRPV1 . FASEB J vol. 21 , ( 11 ) 2695 - 2703 .
Bao Z, Lim SH, Liao WP, Lin YZ, Thiemermann C, Leung BP, Wong WSF ( 2007 ) . Glycogen synthase kinase-3 beta inhibition attenuates asthma in mice . AM J RESP CRIT CARE vol. 176 , ( 5 ) 431 - 438 .
Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Muia C, Abdelrahman M, Di Paola R, Bramanti P et al. ( 2007 ) . Glycogen synthase kinase-3 beta inhibition attenuates the development of bleomycin-induced lung injury . INT J IMMUNOPATH PH vol. 20 , ( 3 ) 619 - 630 .
Bao Z, Lim S, Lin Y, Leung BP, Thiemermann C, Wong WSF ( 2007 ) . Anti-inflammatory effects of GSK-3B inhibitor TDZD-8 in a mouse model of asthma . INFLAMM RES vol. 56 , S416 - S416 .
Dugo L, Collin M, Thiemermann C ( 2007 ) . Erratum: Glycogen synthase kinase-3β as a target for the therapy of shock and inflammation (Shock (2007) 27, (113-123)) . Shock vol. 27 , ( 6 )
Dugo L, Abdelrahman M, Murch O, Mazzon E, Cuzzocrea S, Thiemermann C ( 2007 ) . Glycogen synthase kinase-3beta inhibitors protect against the organ injury and dysfunction caused by hemorrhage and resuscitation . INFLAMM RES vol. 56 , S387 - S387 .
Albuszies G, Vogt J, Wachter U, Thiemermann C, Leverve XM, Weber S, Georgieff M, Radermacher P et al. ( 2007 ) . The effect of iNOS deletion on hepatic gluconeogenesis in hyperdynamic murine septic shock . INTENS CARE MED vol. 33 , ( 6 ) 1094 - 1101 .
Thiemermann C ( 2007 ) . What's new in Shock, June 2007 . SHOCK vol. 27 , ( 6 ) 593 - 596 .
Patel NSA, Cuzzocrea S, Collino M, Chaterjee PK, Mazzon E, Britti D, Yaqoob MM, Thiemermann C ( 2007 ) . The role of cycloxygenase-2 in the rodent kidney following ischaemia/reperfusion injury in vivo . Eur J Pharmacol vol. 562 , ( 1-2 ) 148 - 154 .
Hadley JS, Wang JE, Michaels LC, Dempsey CM, Foster SJ, Thiemermann C, Hinds CJ ( 2007 ) . Alterations in inflammatory capacity and TLR expression on monocytes and neutrophils after cardiopulmonary bypass . Shock vol. 27 , ( 5 ) 466 - 473 .
Maio RF, Figueiredo NL, Sepodes BN, Thiemermann C, Mota-Filipe H, Costa PM ( 2007 ) . Donor pre-treatment with erythropoietin - A way to improve the quality of organs from donation after cardiac death (experimental study) . AMERICAN JOURNAL OF TRANSPLANTATION . vol. 7 , 251 - 251 .
Cuzzocrea S, Mazzon E, Esposito E, Muia C, Abdelrahman M, Di Paola R, Crisafulli C, Bramanti P et al. ( 2007 ) . Glycogen synthase kinase-3 beta inhibition attenuates the development of ischaemia/reperfusion injury of the gut . INTENS CARE MED vol. 33 , ( 5 ) 880 - 893 .
Figueiredo NL, Maio RF, Sepodes BN, Thiemermann C, Mota-Filipe H, Costa PM ( 2007 ) . The effect of donor pre-treatment with erythropoietin in machine perfusion parameters (Experimental study) . AMERICAN JOURNAL OF TRANSPLANTATION . vol. 7 , 508 - 508 .
Thiemermann C ( 2007 ) . What's new in Shock, May 2007? . SHOCK vol. 27 , ( 5 ) 457 - 460 .
Whittle BJ, Varga C, Berko A, Horvath K, Posa A, Molnar A, Thiemermann C ( 2007 ) . Attenuation of indomethacin-induced rat intestinal lesions, TNF alpha-production and iNOS activity by Tdzd-8, an inhibitor of glycogen synthase kinase-3p . GASTROENTEROLOGY . vol. 132 , A564 - A564 .
Cartwright N, Murch O, McMaster SK, Paul-Clark MJ, van Heel DA, Ryffel B, Quesniaux VFJ, Evans TW et al. ( 2007 ) . Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo . Am J Respir Crit Care Med vol. 175 , ( 6 ) 595 - 603 .
Sivarajah A, Collino M, Yasin M, Cuzzocrea S, Thiemermann C ( 2007 ) . Hydrogen sulfide in disease . INFLAMM RES vol. 56 , S261 - S261 .
Thiemermann C ( 2007 ) . Inhibitors of glycogen-synthase kinase 3beta . INFLAMM RES vol. 56 , S260 - S260 .
Dugo L, Collin M, Thiemermann C ( 2007 ) . Glycogen synthase kinase 3beta as a target for the therapy of shock and inflammation . Shock vol. 27 , ( 2 ) 113 - 123 .
Tripatara P, Patel NSA, Webb A, Rathod K, Lecomte FMJ, Mazzon E, Cuzzocrea S, Yaqoob MM et al. ( 2007 ) . Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase . J Am Soc Nephrol vol. 18 , ( 2 ) 570 - 580 .
Thiemermann C ( 2007 ) . Beneficial effects of erythropoietin in preclinical models of shock and organ failure . Crit Care vol. 11 , ( 3 )
Cuzzocrea S, Di Paola R, Mazzon E, Crisafulli C, Genovese T, Muia C, Abdelrahman M, Esposito E et al. ( 2007 ) . Glycogen synthase kinase 3 beta inhibition reduces the development of nonseptic shock induced by zymosan in mice . SHOCK vol. 27 , ( 1 ) 97 - 107 .
Cuzzocrea S, Mazzon E, Esposito E, Muia C, Abdelrahman M, Di Paola R, Crisafulli C, Bramanti P et al. ( 2007 ) . Glycogen synthase kinase-30 inhibition attenuates the development of ischemia/reperfusion injury of the gut . PROCEEDINGS OF THE 7TH WORLD CONGRESS ON TRAUMA, SHOCK, INFLAMMATION AND SEPSIS . 51 - + .
Dugo L, Collin M, Allen DA, Patel NSA, Bauer I, Mervaala E, Louhelainen M, Foster SJ et al. ( 2007 ) . Inhibiting glycogen synthase kinase 3beta in sepsis . Novartis Found Symp vol. 280 , 128 - 142 .
Murch O, Collin M, Hinds CJ, Thiemermann C ( 2007 ) . Lipoproteins in inflammation and sepsis. I. Basic science . Intensive Care Med vol. 33 , ( 1 ) 13 - 24 .
Murch O, Collin M, Thiemermann C ( 2007 ) . Lysophosphatidic acid reduces the organ injury caused by endotoxemia-a role for G-protein-coupled receptors and peroxisome proliferator-activated receptor-gamma . Shock vol. 27 , ( 1 ) 48 - 54 .
Nesic Z, Todorovic Z, Stojanovic R, Basta-Jovanovic G, Radojevic-Skodric S, Velickovic R, Chatterjee PK, Thiemermann C et al. ( 2006 ) . Single-dose intravenous simvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in the rat . J PHARMACOL SCI vol. 102 , ( 4 ) 413 - 417 .
Collino M, Aragno M, Mastrocola R, Benetti E, Gallicchio M, Dianzani C, Danni O, Thiemermann C et al. ( 2006 ) . Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: Effects of the PPAR-alpha agonist WY14643 (vol 41, pg 579, 2006) . FREE RADICAL BIO MED vol. 41 , ( 10 ) 1619 - 1619 .
Cuzzocrea S, Crisafulli C, Mazzon E, Esposito E, Muia C, Abdelrahman M, Di Paola R, Thiemermann C ( 2006 ) . Inhibition of glycogen synthase kinase-3 beta attenuates the development of carrageenan-induced lung injury in mice . BRIT J PHARMACOL vol. 149 , ( 6 ) 687 - 702 .
Sepodes B, Maio R, Pinto R, Sharples E, Oliveira P, McDonald M, Yaqoob M, Thiemermann C et al. ( 2006 ) . Recombinant human erythropoietin protects the liver from hepatic ischemia-reperfusion injury in the rat . TRANSPLANT INT vol. 19 , ( 11 ) 919 - 926 .
Sepodes B, Abdelrahman M, Rocha J, Pinto R, Mota-Filipe H, Thiemermann C ( 2006 ) . A glycogen synthase kinase-3 inhibitor (TDZD-8) attenuates the liver and neuromuscular injury caused by burn in the rat . SHOCK . vol. 26 , 20 - 20 .
McCormick J, Barry SP, Sivarajah A, Stefanutti G, Townsend PA, Lawrence KM, Eaton S, Knight RA et al. ( 2006 ) . Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury . FASEB J vol. 20 , ( 12 ) 2115 - + .
Cuzzocrea S, Genovese T, Mazzon E, Crisafulli C, Di Paola R, Muià C, Collin M, Esposito E et al. ( 2006 ) . GLYCOGEN SYNTHASE KINASE-3β INHIBITION REDUCES SECONDARY DAMAGE IN EXPERIMENTAL SPINAL CORD TRAUMA . Shock vol. 26 , ( 4 )
Cuzzocrea S, Di Paola R, Mazzon E, Crisafulli C, Genovese T, Muia C, Abdelrahman M, Esposito E et al. ( 2006 ) . Glycogen synthase kinase-3 beta inhibition reduces the development of non-septic shock induced by zymosan in mice . SHOCK . vol. 26 , 6 - 7 .
Sepodes B, Rocha J, Abdelrahman M, Pinto R, Oliveira P, Thiemermann C, Mota-Filipe H ( 2006 ) . Inhibition of endogenous hydrogen sulphide formation protects the liver from hepatic ischemia-reperfusion injury in the rat . SHOCK . vol. 26 , 15 - 16 .
Ruud TE, Gundersen Y, Wang JE, Foster SJ, Thiemermann C, Aasen AO ( 2006 ) . Systemic petidoglycan (PegG) stimulates proinflammatory responses in synergy with lipopolysaccharide (LPS) in an in vivo and in vitro porcine model . SHOCK . vol. 26 , 32 - 32 .
Albuszies G, Vogt J, Radermacher P, Weber S, Wachter U, Georgieff M, Thiemermann C, Barth E ( 2006 ) . The role of iNOS for hepatic glucose production in murine septic shock . SHOCK . vol. 26 , 3 - 4 .
Thiemermann C ( 2006 ) . What's new in Shock, October 2006? . SHOCK vol. 26 , ( 4 ) 319 - 321 .
Thiemermann C ( 2006 ) . What's new in Shock, September 2006? . SHOCK vol. 26 , ( 3 ) 223 - 225 .
Collino M, Aragno M, Mastrocola R, Benetti E, Gallicchio M, Dianzani C, Danni O, Thiemermann C et al. ( 2006 ) . Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: Effects of the PPAR-alpha agonist WY14643 . FREE RADICAL BIO MED vol. 41 , ( 4 ) 579 - 589 .
Sivarajah A, McDonald MC, Thiemermann C ( 2006 ) . The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat . Shock vol. 26 , ( 2 ) 154 - 161 .
Bao Z, Lim SH, Thiemermann C, Wong WSF ( 2006 ) . Anti-inflammatory effects of glycogen synthase kinase-3 beta inhibitor in a mouse asthma model . ACTA PHARMACOL SIN vol. 27 , 270 - 270 .
Agren J, Thiemermann C, Foster SJ, Wang JE, Aasen AO ( 2006 ) . Cytokine responses to CpG DNA in human leukocytes . SCAND J IMMUNOL vol. 64 , ( 1 ) 61 - 68 .
Cuzzocrea S, Genovese T, Mazzon E, Crisafulli C, Di Paola R, Muia C, Collin M, Esposito E et al. ( 2006 ) . Glycogen synthase kinase-3 beta inhibition reduces secondary damage in experimental spinal cord trauma . J PHARMACOL EXP THER vol. 318 , ( 1 ) 79 - 89 .
Abdelrahman M, Dugo L, Murch O, Mazzon E, Cuzzocrea S, Thiemermann C ( 2006 ) . Glycogen synthase kinase-3-beta inhibitors attenuate the organ injury/dysfunction caused by hemorrhagic shock . ACTA PHARMACOL SIN vol. 27 , 161 - 161 .
Sepodes B, Abdelrahman M, Pinto R, Figueira ME, Mota-Filipe H, Thiemermann C ( 2006 ) . Glycogen synthase kinase-3b inhibitor, TDZD-8, attenuates the liver injury caused by ischemia-reperfusion in the rat . ACTA PHARMACOL SIN vol. 27 , 278 - 278 .
THIEMERMANN C, Muia C, Di Paola R, Cuzzocrea S, Collin M, Crisafulli C, Dugo L, Mazzon E et al. ( 2006 ) . Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse . Clin. Immunol vol. 120 , ( 1 ) 57 - 67 .
Murch O, Collin M, Sepodes B, Foster SJ, Mota-Filipe H, Thiemermann C ( 2006 ) . Lysophosphatidylcholine reduces the organ injury and dysfunction in rodent models of gram-negative and gram-positive shock . Br J Pharmacol vol. 148 , ( 6 ) 769 - 777 .
Thiemermann C ( 2006 ) . Poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of Ischemia-Reperfusion injury . ACTA PHARMACOL SIN vol. 27 , 37 - 37 .
Bar-Or D, McDonald MC, Thiemermann C ( 2006 ) . Reduction of infarct size in a rat model of regional myocardial ischemia and reperfusion by the synthetic peptide DAHK . CRIT CARE MED vol. 34 , ( 7 ) 1955 - 1959 .
Thiemermann C ( 2006 ) . The spice of life: Curcumin reduces the mortality associated with experimental sepsis . CRIT CARE MED vol. 34 , ( 7 ) 2009 - 2011 .
Wang YY, Dahle MK, Collins JL, Thiemermann C, Aasen AO, Wang JE ( 2006 ) . Activation of liver x receptor by synthetic agonist t0901317 reduces the liver injury caused by lipopolysaccharide in the rat: A novel principle for treatment of sepsis and shock . SHOCK . vol. 25 , 72 - 72 .
Myhre AE, Lyngstadaas SP, Dahle MK, Stuestol JF, Foster SJ, Thiemermann C, Lilleaasen P, Wang JE et al. ( 2006 ) . Anti-inflammatory properties of enamel matrix derivative in human blood . J PERIODONTAL RES vol. 41 , ( 3 ) 208 - 213 .
Patel NSA, Tripatara P, Thiemermann C ( 2006 ) . Inhibition of hydrogen sulfide synthesis protects the rat kidney in vivo against ischemia-reperfusion injury . SHOCK . vol. 25 , 37 - 37 .
Murch O, Wray J, Collin M, Bishop-Bailey D, Thiemermann C ( 2006 ) . Lysophosphatidic acid reduces the organ injury caused by endotoxemia via activation of G-protein-coupled receptors, but not peroxisome proliferator-activated receptor gamma . SHOCK . vol. 25 , 72 - 72 .
Lovell M, McDonald M, Sivarajah A, Harrington D, Ferguson S, Wright N, Thiemermann C, Mathur A ( 2006 ) . Bone marrow mononuclear cells home to the heart in the acute setting of myocardial infarction with no adverse effects on cardiac function . HEART . vol. 92 , A70 - A71 .
Dugo L, Abdelrahman M, Murch O, Mazzon E, Cuzzocrea S, Thiemermann C ( 2006 ) . Glycogen synthase kinase-3beta inhibitors protect against the organ injury and dysfunction caused by hemorrhage and resuscitation . Shock vol. 25 , ( 5 ) 485 - 491 .
Dugo L, Collin M, Allen DA, Murch O, Foster SJ, Yaqoob MM, Thiemermann C ( 2006 ) . Insulin reduces the multiple organ injury and dysfunction caused by coadministration of lipopolysaccharide and peptidoglycan independently of blood glucose: role of glycogen synthase kinase-3beta inhibition . Crit Care Med vol. 34 , ( 5 ) 1489 - 1496 .
Lovell M, McDonald M, Sivarajah A, Wright N, Thiemermann C, Mathur A ( 2006 ) . Localisation of bone marrow mononuclear cells administered during acute myocardial infarction; The effects of time in culture . HEART . vol. 92 , A69 - A70 .
Thiemermann C ( 2006 ) . What's new in SHOCK, May 2006? . SHOCK vol. 25 , ( 5 ) 429 - 431 .
Thiemermann C, Yaqoob MM ( 2006 ) . Cardio-renal interface in translational and clinical research . CURR OPIN PHARMACOL vol. 6 , ( 2 ) 121 - 124 .
Cuzzocrea S, Di Paola R, Mazzon E, Patel NSA, Genovese T, Muia C, Crisafulli C, Caputi AP et al. ( 2006 ) . Erythropoietin reduces the development of nonseptic shock induced by zymosan in mice . CRIT CARE MED vol. 34 , ( 4 ) 1168 - 1177 .
Whittle BJ, Varga C, Berko A, Posa A, Molnar A, Collin M, Thiemermann C ( 2006 ) . Modulation of rat colonic TNF-alpha, iNOS and acute colitis through down-regulation of NF-kappa B by glycogen synthase kinase-3 beta inhibition . GASTROENTEROLOGY . vol. 130 , A551 - A551 .
Sharples EJ, Thiemermann C, Yaqoob MM ( 2006 ) . Novel applications of recombinant erythropoietin . Curr Opin Pharmacol vol. 6 , ( 2 ) 184 - 189 .
Collin M, Murch O, Thiemermann C ( 2006 ) . Peroxisome proliferator-activated receptor-gamma antagonists GW9662 and T0070907 reduce the protective effects of lipopolysaccharide preconditioning against organ failure caused by endotoxemia . CRIT CARE MED vol. 34 , ( 4 ) 1131 - 1138 .
Collin M, Murch O, Thiemermann C ( 2006 ) . Peroxisome proliferator-activated receptor-gamma antagonists GW9662 and T0070907 reduce the protective effects of lipopolysaccharide preconditioning against organ failure caused by endotoxemia . Crit Care Med vol. 34 , ( 4 ) 1131 - 1138 .
Goddard A, McDonald M, Thiemermann C, Ahluwalia A ( 2006 ) . Identification of an endogenous cardioprotective pathway involving 12-lipoxygenase (12-LOX), C-fibers and the non-selective cation channel TRPV1 . FASEB JOURNAL . vol. 20 , A230 - A230 .
Myhre AE, Aasen AO, Thiemermann C, Wang JE ( 2006 ) . Peptidoglycan - An endotoxin in its own right? . SHOCK vol. 25 , ( 3 ) 227 - 235 .
Whittle BJR, Varga C, Pósa A, Molnár A, Collin M, Thiemermann C ( 2006 ) . Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase-3beta . Br J Pharmacol vol. 147 , ( 5 ) 575 - 582 .
Wang YY, Dahle MK, Agren J, Myhre AE, Reinholt FP, Foster SJ, Collins JL, Thiemermann C et al. ( 2006 ) . Activation of the liver X receptor protects against hepatic injury in endotoxemia by suppressing Kupffer cell activation . SHOCK vol. 25 , ( 2 ) 141 - 146 .
Barth E, Radermacher P, Thiemermann C, Weber S, Georgieff M, Albuszies G ( 2006 ) . Role of inducible nitric oxide synthase in the reduced responsiveness of the myocardium to catecholamines in a hyperdynamic, murine model of septic shock . CRIT CARE MED vol. 34 , ( 2 ) 307 - 313 .
Collino M, Aragno M, Mastrocola R, Gallichio M, Rosa AC, Dianzani C, Danni O, Thiemermann C et al. ( 2006 ) . Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion . EUR J PHARMACOL vol. 530 , ( 1-2 ) 70 - 80 .
THIEMERMANN C, Gallicchio M, Danni O, Rosa AC, Dianzani C, Fantoozzi R, Mastrocola R, Aragno M et al. ( 2006 ) . Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion . Eur J Pharmacol vol. 530 , ( 1-2 ) 70 - 70 .
Wang YY, Dahle MK, Aasen AO, Wang JE, Reinholt FP, Collins JL, Thiemermann C ( 2005 ) . Activation of the liver X receptor by GW3965 protects against hepatic injury in endotoxemia . CRITICAL CARE MEDICINE . vol. 33 , A138 - A138 .
Collin M, Thiemermann C ( 2005 ) . Hydrogen sulfide and sulfite: Novel mediators in the pathophysiology of shock and inflammation . SHOCK vol. 24 , ( 6 ) 595 - 596 .
Sharples EJ, Thiemermann C, Yaqoob MM ( 2005 ) . Mechanisms of disease: Cell death in acute renal failure and emerging evidence for a protective role of erythropoietin . Nat Clin Pract Nephrol vol. 1 , ( 2 ) 87 - 97 .
Balachandra S, Genovese T, Mazzon E, Di Paola R, Thiemerman C, Siriwardena AK, Cuzzocrea S ( 2005 ) . Inhibition of tyrosine-kinase-mediated cellular signaling by tyrphostins AG 126 and AG556 modulates murine experimental acute pancreatitis . Surgery vol. 138 , ( 5 ) 913 - 923 .
Hadley JS, Wang JE, Foster SJ, Thiemermann C, Hinds CJ ( 2005 ) . Peptidoglycan of Staphylococcus aureus upregulates monocyte expression of CD14, Toll-like receptor 2 (TLR2), and TLR4 in human blood: possible implications for priming of lipopolysaccharide signaling . Infect Immun vol. 73 , ( 11 ) 7613 - 7619 .
Collin M, Anuar FBM, Murch O, Bhatia M, Moore PK, Thiemermann C ( 2005 ) . Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia . Br J Pharmacol vol. 146 , ( 4 ) 498 - 505 .
Dugo L, Collin M, Allen DA, Patel NSA, Bauer I, Mervaala EMA, Louhelainen M, Foster SJ et al. ( 2005 ) . GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat . Crit Care Med vol. 33 , ( 9 ) 1903 - 1912 .
Wang YY, Myhre AE, Pettersen SJ, Dahle MK, Foster SJ, Thiemermann C, Bjørnland K, Aasen AO et al. ( 2005 ) . Peptidoglycan of Staphylococcus aureus induces enhanced levels of matrix metalloproteinase-9 in human blood originating from neutrophils . Shock vol. 24 , ( 3 ) 214 - 218 .
Collino M, Patel NSA, Lawrence KM, Collin M, Latchman DS, Yaqoob MM, Thiemermann C ( 2005 ) . The selective PPARgamma antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion . Kidney Int vol. 68 , ( 2 ) 529 - 536 .
Collin M, Murch O, Thiemermann C ( 2005 ) . Lysophosphatidylcholine reduces the multiple organ injury and dysfunction caused by endotoxemia in the rat . SHOCK . vol. 23 , 41 - 41 .
Sivarajah A, McDonald MC, Thiemermann C ( 2005 ) . The cardioprotective effects of endotoxin are abolished by the PPAR-g antagonist GW9662 . JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY . vol. 38 , 1068 - 1068 .
Sivarajah A, McDonald MC, Thiemermann C ( 2005 ) . The cardioprotective effects of endotoxin but not ischemia are abolished by the PPAR-gamma antagonist GW9662 . SHOCK . vol. 23 , 31 - 31 .
Patel NSA, Collino M, Collin M, Thiemermann C ( 2005 ) . The selective PPAR gamma antagonist GW9662 abolished the protection afforded by lpspretreatment in a rat model of renal ischemia/reperfusion injury . SHOCK . vol. 23 , 30 - 31 .
Genovese T, Mazzon E, Di Paola R, Muia C, Threadgill MD, Caputi AP, Thiemermann C, Cuzzocrea S ( 2005 ) . Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury . J PHARMACOL EXP THER vol. 313 , ( 2 ) 529 - 538 .
Sivarajah A, McDonald MC, Thiemermann C ( 2005 ) . The cardioprotective effects of preconditioning with endotoxin, but not ischemia, are abolished by a peroxisome proliferator-activated receptor-gamma antagonist . J Pharmacol Exp Ther vol. 313 , ( 2 ) 896 - 901 .
Chatterjee PK, Todorovic Z, Sivarajah A, Mota-Filipe H, Brown PAJ, Stewart KN, Mazzon E, Cuzzocrea S et al. ( 2005 ) . Inhibitors of calpain activation (PD150606 and E-64) and renal ischemia-reperfusion injury . Biochem Pharmacol vol. 69 , ( 7 ) 1121 - 1131 .
Abdelrahman M, Sivarajah A, Thiemermann C ( 2005 ) . Beneficial effects of PPAR-gamma ligands in ischemia-reperfusion injury, inflammation and shock . Cardiovasc Res vol. 65 , ( 4 ) 772 - 781 .
Patel NSA, Chatterjee PK, Di Paola R, Mazzon E, Britti D, De Sarro A, Cuzzocrea S, Thiemermann C ( 2005 ) . Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion . J Pharmacol Exp Ther vol. 312 , ( 3 ) 1170 - 1178 .
Cuzzocrea S, Mazzon E, di Paola R, Genovese T, Patel NSA, Britti D, de Majo M, Caputi AP et al. ( 2005 ) . Erythropoietin reduces the degree of arthritis caused by type II collagen in the mouse . Arthritis Rheum vol. 52 , ( 3 ) 940 - 950 .
Patel NSA, Cortes U, Di Poala R, Mazzon E, Mota-Filipe H, Cuzzocrea S, Wang Z-Q, Thiemermann C ( 2005 ) . Mice lacking the 110-kD isoform of poly(ADP-ribose) glycohydrolase are protected against renal ischemia/reperfusion injury . J Am Soc Nephrol vol. 16 , ( 3 ) 712 - 719 .
Genovese T, Cuzzocrea S, Di Paola R, Mazzon E, Mastruzzo C, Catalano P, Sortino M, Crimi N et al. ( 2005 ) . Effect of rosiglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) on bleomycin-induced lung injury . EUR RESPIR J vol. 25 , ( 2 ) 225 - 234 .
Abdelrahman M, Mazzon E, Bauer M, Bauer I, Delbosc S, Cristol J-P, Patel NSA, Cuzzocrea S et al. ( 2005 ) . Inhibitors of NADPH oxidase reduce the organ injury in hemorrhagic shock . Shock vol. 23 , ( 2 ) 107 - 114 .
Genovese T, Mazzon E, Muia C, Patel NSA, Threadgill MD, Bramanti P, De Sarro A, Thiemermann C et al. ( 2005 ) . Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma . J PHARMACOL EXP THER vol. 312 , ( 2 ) 449 - 457 .
Di Paola R, Mazzon E, Patel NSA, Genovese T, Muia C, Thiemermann C, De Sarro A, Cuzzocrea S ( 2005 ) . Beneficial effects of GW274150 treatment on the development of experimental colitis induced by dinitrobenzene sulfonic acid . EUR J PHARMACOL vol. 507 , ( 1-3 ) 281 - 289 .
Dugo L, Collin M, Cuzzocrea S, Thiemermann C ( 2005 ) . 15d-PGJ(2) reduces the multiple organ failure caused by wall-fragments of Gram-positive and Gram-negative bacteria . SHOCK . vol. 23 , 42 - 42 .
Di Paola R, Genovese T, Caputi AP, Threadgill M, Thiemermann C, Cuzzocrea S ( 2005 ) . Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of the of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion . SHOCK . vol. 23 , 13 - 14 .
Barth E, Radermacher P, Thiemermann C, Weber S, Georgieff M, Albuszies G ( 2005 ) . Effetcs of selective iNOS inhibition with GW274150 on catecholamine reactivity during hyperdynamic murine septic shock . SHOCK . vol. 23 , 57 - 57 .
Abdelrahman M, Bauer M, Bauer I, Delbosc S, Cristol JP, Patel NSA, Cuzzocrea S, Thiemermann C ( 2005 ) . Inhibitors of NADPH oxidase reduce the organ injury in hemorrhagic shock . SHOCK . vol. 23 , 53 - 53 .
Genovese T, Mazzon E, Muia C, Patel NSA, Threadgill MD, Bramanti P, De Sarro A, Thiemermann C et al. ( 2005 ) . Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma . SHOCK . vol. 23 , 19 - 19 .
Patel NSA, Cortes U, Di Poala R, Mazzon E, Filipe HM, Cuzzocrea S, Wang ZQ, Thiemermann C ( 2005 ) . Mice lacking the 110 KDa isoform of poly(ADP-ribose) glycohydrolase are protected against renal ischemia-reperfusion injury . SHOCK . vol. 23 , 40 - 40 .
Klouche K, Delbosc S, Abdelrahman M, Cristol JP, Thiemermann C ( 2005 ) . Oxidative stress tissular production precedes organ dysfunction during animal septic shock . SHOCK . vol. 23 , 51 - 51 .
WHITTLE BJR, Thiemermann C, Collin M, Varga C, Posa A, Molnar A ( 2005 ) . Reduction of Experimental Colitis in the Rat by Inhibitors of Glycogen Synthase Kinase-3b . J Pharmacol vol. 147 , 575 - 582 .
Cuzzocrea S, Dugo L, Patel NSA, Di Paola R, Genovese T, Muia C, Caputi AP, Thiemermann C ( 2005 ) . Rosiglitazont and 15-deoxy-Delta(12,14)-prostaglandin J(2), ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut . SHOCK . vol. 23 , 41 - 42 .
Agren J, Foster SJ, Thiemermann C, Wang JE, Aasen AO ( 2005 ) . Synthetic CpG- and GpC oligonucleotides enhance the TNF alpha release induced by peptidoglycan but not by lipopolysaccharide . SHOCK . vol. 23 , 22 - 22 .
Sivarajah A, McDonald MC, Thiemermann C ( 2005 ) . The cardioprotective effects of preconditioning with endotoxin, but not ischemia, are abolished by a PPAR-gamma antagonist . SHOCK . vol. 23 , 41 - 41 .
Hadley JS, Wang JE, Michaels LC, Foster SJ, Thiemermann C, Hinds CJ ( 2005 ) . The effect of cardiopulmonary bypass (CPB) on monocyte receptor expression and ex vivo cytokine production . SHOCK . vol. 23 , 72 - 72 .
Sepodes B, Pinto R, McDonald M, Eduardo-Figueira M, Thiemermann C, Mota-Filipe H ( 2005 ) . Tyrphostin AG126 reduces ischemia-reperfusion injury of the liver in the rat . SHOCK . vol. 23 , 39 - 39 .
Cuzzocrea S, Mazzon E, Di Paola R, Genovese T, Patel NSA, Muia C, Threadgill MD, De Sarro A et al. ( 2004 ) . 5-Aminoisoquinolinone reduces colon injury by experimental colitis . N-S ARCH PHARMACOL vol. 370 , ( 6 ) 464 - 473 .
Cuzzocrea S, Mazzon E, Di Paola R, Patel NSA, Genovese T, Muia C, De Sarro A, Thiemermann C ( 2004 ) . Erythropoietin reduces the development of experimental inflammatory bowel disease . J PHARMACOL EXP THER vol. 311 , ( 3 ) 1272 - 1280 .
Hauser B, Radermacher P, Thiemermann C, Matejovic M ( 2004 ) . Nitric oxide, bacteria, and host defense in sepsis: Who needs what? . SHOCK vol. 22 , ( 6 ) 588 - 590 .
Abdelrahman M, Collin M, Thiemermann C ( 2004 ) . The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock . Shock vol. 22 , ( 6 ) 555 - 561 .
Collin M, Rossi A, Cuzzocrea S, Patel NSA, Di Paola R, Hadley J, Collino M, Sautebin L et al. ( 2004 ) . Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton . J Leukoc Biol vol. 76 , ( 5 ) 961 - 970 .
Chatterjee PK, Todorovic Z, Sivarajah A, Mota-Filipe H, Brown PAJ, Stewart KN, Cuzzocrea S, Thiemermann C ( 2004 ) . Differential effects of caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney . Eur J Pharmacol vol. 503 , ( 1-3 ) 173 - 183 .
Petrilli V, Herceg Z, Hassa PO, Patel NSA, Di Paola R, Cortes U, Dugo L, Filipe HM et al. ( 2004 ) . Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammatbn response in mice . J CLIN INVEST vol. 114 , ( 8 ) 1072 - 1081 .
Wang JE, Pettersen S, Stuestol JF, Wang YY, Foster SJ, Thiemermann C, Aasen AO, Bjorland K ( 2004 ) . Peptidoglycan of S-aureus causes increased levels of matrix metalloproteinases in the rat . SHOCK vol. 22 , ( 4 ) 376 - 379 .
Dugo L, Collin M, Cuzzocrea S, Thiemermann C ( 2004 ) . 15d-prostaglandin J2 reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria . Eur J Pharmacol vol. 498 , ( 1-3 ) 295 - 301 .
Patel NSA, Sharples EJ, Cuzzocrea S, Chatterjee PK, Britti D, Yaqoob MM, Thiemermann C ( 2004 ) . Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivo . Kidney Int vol. 66 , ( 3 ) 983 - 989 .
Patel NSA, Collin M, Thiemermann C ( 2004 ) . Urocortin does not reduce the renal injury and dysfunction caused by experimental ischaemia/reperfusion . Eur J Pharmacol vol. 496 , ( 1-3 ) 175 - 180 .
Virlos I, Mazzon E, Serraino I, Genovese T, Di Paola R, Thiemerman C, Siriwardena A, Cuzzocrea S ( 2004 ) . Calpain I inhibitor ameliorates the indices of disease severity in a murine model of cerulein-induced acute pancreatitis . Intensive Care Med vol. 30 , ( 8 ) 1645 - 1651 .
Sharples EJ, Patel N, Brown P, Stewart K, Mota-Philipe H, Sheaff M, Kieswich J, Allen D et al. ( 2004 ) . Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion . J Am Soc Nephrol vol. 15 , ( 8 ) 2115 - 2124 .
Patel NSA, Cuzzocrea S, Chatterjee PK, Di Paola R, Sautebin L, Britti D, Thiemermann C ( 2004 ) . Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton . Mol Pharmacol vol. 66 , ( 2 ) 220 - 227 .
Cuzzocrea S, Pisano B, Dugo L, Ianaro A, Patel NSA, Caputi AP, Thiemermann C ( 2004 ) . Tempol reduces the activation of nuclear factor-kappa B in acute inflammation . FREE RADICAL RES vol. 38 , ( 8 ) 813 - 819 .
Cuzzocrea S, Genovese T, Di Paola R, Mastruzzo C, Dugo L, Sortino M, Crimi N, Caputi AP et al. ( 2004 ) . Effect of rosiglitazone and 15-deoxy-Delta 12,14-prostaglandin J2 on bleomycin-induced lung injury . FUNDAMENTAL & CLINICAL PHARMACOLOGY vol. 18 , 90 - 90 .
Abdelrahman M, Sharples EJ, McDonald MC, Collin M, Patel NSA, Yaqoob MM, Thiemermann C ( 2004 ) . Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia . Shock vol. 22 , ( 1 ) 63 - 69 .
Thiemermann C ( 2004 ) . Inhibition of the activation of nuclear factor kappa B to reduce myocardial reperfusion injury and infarct size . CARDIOVASC RES vol. 63 , ( 1 ) 8 - 10 .
Thiemermann C ( 2004 ) . Ligands of the peroxisome proliferator-activated receptor-gamma and heart failure . Br J Pharmacol vol. 142 , ( 6 ) 1049 - 1051 .
Cuzzocrea S, Mazzon E, Dugo L, Patel N, Di Paola R, Genovese T, Britti D, De Majo M et al. ( 2004 ) . Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce the evolution of murine type II collagen-induced arthritis . FUNDAMENTAL & CLINICAL PHARMACOLOGY vol. 18 , 90 - 90 .
Sepodes B, Pinto R, McDonald M, Thiemermann C, Mota-Filipe H ( 2004 ) . The effect of haemoglobin pretreatment on the liver ischaemia/reperfusion injury . FUNDAMENTAL & CLINICAL PHARMACOLOGY vol. 18 , 124 - 124 .
Cuzzocrea S, Pisano B, Dugo L, Ianaro A, Britti D, Patel NSA, Paola RD, Genovese T et al. ( 2004 ) . Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute pancreatitis induced by cerulein . INTENS CARE MED vol. 30 , ( 5 ) 951 - 956 .
Sepodes B, Maio R, Pinto R, Marques C, Mendes-Do-Vale J, McDonald MC, Thiemermann C, Mota-Filipe H ( 2004 ) . Tempol, an intracelullar free radical scavenger, reduces liver injury in hepatic ischemia-reperfusion in the rat . TRANSPLANTATION PROCEEDINGS . vol. 36 , 849 - 853 .
Cuzzocrea S, Dugo L, Patel NSA, Di Paola R, Cockerill GW, Genovese T, Thiemermann C ( 2004 ) . High-density lipoproteins reduce the intestinal damage associated with ischemia/reperfusion and colitis . SHOCK vol. 21 , ( 4 ) 342 - 351 .
Thiemermann C, Abdelrahman M, Patel N, Sharples E, Yaqoob MM ( 2004 ) . BENEFICIAL EFFECTS OF ERYTHROPOEIN IN SHOCK AND ISCHEMIA REPERFUSION INJURY . Shock vol. 21 , ( Supplement )
Chatterjee PK, Patel NSA, Kvale EO, Brown PAJ, Stewart KN, Mota-Filipe H, Sharpe MA, Di Paola R et al. ( 2004 ) . EUK-134 reduces renal dysfunction and injury caused by oxidative and nitrosative stress of the kidney . Am J Nephrol vol. 24 , ( 2 ) 165 - 177 .
Wu AH, Hinds CJ, Thiemermann C ( 2004 ) . High-density lipoproteins in sepsis and septic shock: Metabolism, actions, and therapeutic applications . SHOCK vol. 21 , ( 3 ) 210 - 221 .
Myhre AE, Stuestol JF, Dahle MK, Overland G, Thiemermann C, Foster SJ, Lilleaasen P, Aasen AO et al. ( 2004 ) . Organ injury and cytokine release caused by peptidoglycan are dependent on the structural integrity of the glycan chain . INFECT IMMUN vol. 72 , ( 3 ) 1311 - 1317 .
Al-Ghamdi SS, Chatterjee PK, Raftery MJ, Thiemermann C, Yaqoob MM ( 2004 ) . Role of cytochrome P4502E1 activation in proximal tubular cell injury induced by hydrogen peroxide . Ren Fail vol. 26 , ( 2 ) 103 - 110 .
Collin M, Patel NSA, Dugo L, Thiemermann C ( 2004 ) . Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxy Delta(12,14) prostaglandin J(2) against the multiple organ failure caused by endotoxin . CRIT CARE MED vol. 32 , ( 3 ) 826 - 831 .
Collin M, Abdelrahman M, Thiemermann C ( 2004 ) . Endogenous ligands of PPAR-gamma reduce the liver injury in haemorrhagic shock . Eur J Pharmacol vol. 486 , ( 2 ) 233 - 235 .
Chatterjee PK, Patel NSA, Cuzzocrea S, Brown PAJ, Stewart KN, Mota-Filipe H, Britti D, Eberhardt W et al. ( 2004 ) . The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure . Cardiovasc Res vol. 61 , ( 3 ) 630 - 643 .
Chatterjee PK, Chatterjee BE, Pedersen H, Sivarajah A, McDonald MC, Mota-Filipe H, Brown PAJ, Stewart KN et al. ( 2004 ) . 5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia/reperfusion . Kidney Int vol. 65 , ( 2 ) 499 - 509 .
Wang JE, Dahle MK, Yndestad A, Bauer I, McDonald MC, Aukrust P, Foster SJ, Bauer M et al. ( 2004 ) . Peptidoglycan of Staphylococcus aureus causes inflammation and organ injury in the rat . CRIT CARE MED vol. 32 , ( 2 ) 546 - 552 .
Cuzzocrea S, Pisano B, Dugo L, Ianaro A, Patel NSA, Di Paola R, Genovese T, Chatterjee PK et al. ( 2004 ) . Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces the development of nonseptic shock induced by zymosan in mice . CRIT CARE MED vol. 32 , ( 2 ) 457 - 466 .
THIEMERMANN C, Cuzzocrea S, Genovese T, Di Paola R, Caputi AP, Threadgill M ( 2004 ) . Benefical effects of 5-aminoisoquinolinone, a novel, potent, water-soluable, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occulsion and reperfusion . European Journal of Pharmacology vol. 492 , 203 - 210 .
Marzocco S, Di Paola R, Autore G, Mazzon E, Pinto A, Caputi AP, Thiemermann C, Cuzzocrea S ( 2004 ) . Calpain inhibitor I reduces intestinal ischemia-reperfusion injury in the rat . SHOCK vol. 21 , ( 1 ) 38 - 44 .
Hadley JS, Wang JE, Foster SJ, Thiemermann C, Hinds CJ ( 2004 ) . Cytokine responses to combined administration of lipopolysaccharide (LPS) and peptidoglycan (PepG) . SHOCK . vol. 21 , 50 - 50 .
Sepodes B, Pinto R, McDonald MC, Thiemermann C, Mota-Filipe H ( 2004 ) . Effect of recombinant human erythropoietin in a rat model of ischemia-reperfusion injury of the liver . SHOCK . vol. 21 , 87 - 87 .
Thiemermann C ( 2004 ) . Ligands of the peroxisome proliferator-activated receptor-gamma and heart failure . Br J Pharmacol vol. 141 , ( 1 ) 1 - 3 .
Hadley JS, Wang JE, Foster SJ, Thiemermann C, Hinds CJ ( 2004 ) . Monocyte cell surface receptor upregulation in response to stimulation with lipopolysaccharide and peptidoglycan . SHOCK . vol. 21 , 21 - 21 .
Wang JE, Dahle MK, Aasen AO, Foster SJ, Thiemermann C ( 2004 ) . Peptidoglycan causes local and systemic inflammation in the rat . SHOCK . vol. 21 , 148 - 148 .
THIEMERMANN C, Salvemini D, Cuzzocrea S ( 2004 ) . Potential therapeutic effect of antioxidant therapy in shock and inflammation . Curr. Medicinal Chemistry vol. 11 , 1147 - 1162 .
Cuzzocrea S, Pisano B, Dugo L, Ianaro A, Maffia P, Patel NSA, Di Paola R, Ialenti A et al. ( 2004 ) . Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation . EUR J PHARMACOL vol. 483 , ( 1 ) 79 - 93 .
Chatterjee PK, di Villa Bianca RD, Sivarajah A, McDonald MC, Cuzzocrea S, Thiemermann C ( 2003 ) . Pyrrolidine dithiocarbamate reduces renal dysfunction and injury caused by ischemia/reperfusion of the rat kidney . Eur J Pharmacol vol. 482 , ( 1-3 ) 271 - 280 .
Keller T, Pleskova M, McDonald MC, Thiemermann C, Pfeilschifter J, Beck KF ( 2003 ) . Identification of manganese superoxide dismutase as a NO-regulated gene in rat glomerular mesangial cells by 2D gel electrophoresis . NITRIC OXIDE-BIOL CH vol. 9 , ( 4 ) 183 - 193 .
Virlos I, Mazzon E, Serraino I, Di Paola R, Genovese T, Britti D, Thiemerman C, Siriwardena A et al. ( 2003 ) . Pyrrolidine dithiocarbamate reduces the severity of cerulein-induced murine acute pancreatitis . Shock vol. 20 , ( 6 ) 544 - 550 .
McDonald MC, Dhadly P, Cockerill GW, Cuzzocrea S, Mota-Filipe H, Hinds CJ, Miller NE, Thiemermann C ( 2003 ) . Reconstituted high-density lipoprotein attenuates organ injury and adhesion molecule expression in a rodent model of endotoxic shock . Shock vol. 20 , ( 6 ) 551 - 557 .
Cuzzocrea S, Mazzon E, Dugo L, Patel NSA, Serraino I, Di Paola R, Genovese T, Britti D et al. ( 2003 ) . Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma . ARTHRITIS RHEUM vol. 48 , ( 12 ) 3544 - 3556 .
Chatterjee PK, Thiemermann C ( 2003 ) . Emerging drugs for renal failure . Expert Opinion on Emerging Drugs vol. 8 , ( 2 ) 389 - 435 .
Sharples EJ, Patel N, Brown P, Stewart K, Mota-Philipe H, Sheaff M, Allen DA, Harwood SM et al. ( 2003 ) . Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion injury by the inhibition of the caspase cascade and apoptosis . JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY . vol. 14 , 273A - 273A .
Wang JE, Dahle MK, McDonald M, Foster SJ, Aasen AO, Thiemermann C ( 2003 ) . Peptidoglycan and lipoteichoic acid in gram-positive bacterial sepsis: receptors, signal transduction, biological effects, and synergism . Shock vol. 20 , ( 5 ) 402 - 414 .
Cuzzocrea S, Rossi A, Pisano B, Di Paola R, Genovese T, Patel NSA, Cuzzocrea E, Ianaro A et al. ( 2003 ) . Pyrrolidine dithiocarbamate attenuates the development of organ failure induced by zymosan in mice . INTENS CARE MED vol. 29 , ( 11 ) 2016 - 2025 .
Chatterjee PK, Patel NSA, Kvale EO, Brown PAJ, Stewart KN, Britti D, Cuzzocrea S, Mota-Filipe H et al. ( 2003 ) . The tyrosine kinase inhibitor tyrphostin AG126 reduces renal ischemia/reperfusion injury in the rat . Kidney Int vol. 64 , ( 5 ) 1605 - 1619 .
Chatterjee PK, Kvale EO, Patel NSA, Thiemermann C ( 2003 ) . GW274150 inhibits nitric oxide production by primary cultures of rat proximal tubular cells . Med Sci Monit vol. 9 , ( 10 ) BR357 - BR362 .
Muscoli C, Cuzzocrea S, Riley DP, Zweier JL, Thiemermann C, Wang ZQ, Salvemini D ( 2003 ) . On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies . BRIT J PHARMACOL vol. 140 , ( 3 ) 445 - 460 .
Cuzzocrea S, Pisano B, Dugo L, Ianaro A, Patel NSA, Di Paola R, Genovese T, Chatterjee PK et al. ( 2003 ) . Rosiglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut . BRIT J PHARMACOL vol. 140 , ( 2 ) 366 - 376 .
McDonald M, Abdelrahman M, Cuzzocrea S, Thiemermann C ( 2003 ) . Tyrphostin reduces the organ injury in haemorrhagic shock: role of inducible nitric oxide synthase . Resuscitation vol. 58 , ( 3 ) 349 - 361 .
Collin M, Thiemermann C ( 2003 ) . The PPAR-gamma ligand 15-deoxy(delta12,14) prostaglandin J2 reduces the liver injury in endotoxic shock . Eur J Pharmacol vol. 476 , ( 3 ) 257 - 258 .
Wang Y, Chang CF, Morales M, Chiang YH, Harvey BK, Su TP, Tsao LI, Chen SY et al. ( 2003 ) . Diadenosine tetraphosphate protects against injuries induced by ischemia and 6-hydroxydopamine in rat brain . J NEUROSCI vol. 23 , ( 21 ) 7958 - 7965 .
Sivarajah A, Chatterjee PK, Patel NSA, Todorovic Z, Hattori Y, Brown PAJ, Stewart KN, Mota-Filipe H et al. ( 2003 ) . Agonists of peroxisome-proliferator activated receptor-gamma reduce renal ischemia/reperfusion injury . Am J Nephrol vol. 23 , ( 4 ) 267 - 276 .
Thiemermann C, Patel NSA, Kvale EO, Cockerill GW, Brown PAJ, Stewart KN, Cuzzocrea S, Britti D et al. ( 2003 ) . High density lipoprotein (HDL) reduces renal ischemia/reperfusion injury . J Am Soc Nephrol vol. 14 , ( 7 ) 1833 - 1843 .
Thiemermann C, Abdelrahman M, Patel N, Sharples E, Chatterjee PK, Yaqoob MM ( 2003 ) . ERYTHROPOETIN REDUCES THE RENAL INJURY CAUSED BY HEMORRHAGIC SHOCK OR ISCHEMIA REPERFUSION IN THE RAT . Shock vol. 19 , ( Supplement )
Sipola M, Patel N, Dugo L, Sharples E, Yaqoob M, Thiemermann C ( 2003 ) . LACK OF EFFECT OF ERYTHROPOIETIN (EPO) ON RENAL OR LIVER FAILURE IN ENDOTOXIC SHOCK IN THE RAT . Shock vol. 19 , ( Supplement )
Abdelrahman M, Bauer I, Bauer M, Thiemermann C ( 2003 ) . THE RADICAL SCAVENGER TEMPONE REDUCES THE ACTIVATION OF AP-1 AND THE RENAL AND LIVER INJURY CAUSED BY HEMORRHAGIC SHOCK IN THE ANESTHETIZED RAT . Shock vol. 19 , ( Supplement )
Wayman NS, Ellis BL, Thiemermann C ( 2003 ) . Simvastatin reduces infarct size in a model of acute myocardial ischemia and reperfusion in the rat . Med Sci Monit vol. 9 , ( 5 ) BR155 - BR159 .
McDonald MC, d'Emmanuele di Villa Bianca R, Wayman NS, Pinto A, Sharpe MA, Cuzzocrea S, Chatterjee PK, Thiemermann C ( 2003 ) . A superoxide dismutase mimetic with catalase activity (EUK-8) reduces the organ injury in endotoxic shock . Eur J Pharmacol vol. 466 , ( 1-2 ) 181 - 189 .
Chatterjee PK, Thiemermann C ( 2003 ) . An In Vivo Model of Ischemia/Reperfusion and Inflammation of the Kidneys of the Rat . Inflammation Protocols , vol. 225 ,
Wayman NS, McDonald MC, Chatterjee PK, Thiemermann C ( 2003 ) . Models of Coronary Artery Occlusion and Reperfusion for the Discovery of Novel Antiischemic and Antiinflammatory Drugs for the Heart . Inflammation Protocols , vol. 225 ,
Sivarajah A, Chatterjee PK, Todorovic Z, Mota-Filipe H, Brown PAJ, Stewart KN, Thiemermann C ( 2003 ) . Agonists of peroxisome proliferator activated receptor-alpha (clofibrate and WY14643) reduce ischaemia/reperfusion injury of the rat kidney . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U47 - U47 .
Chatterjee PK, Sivarajah A, Todorovic Z, Mota-Filipe H, Brown PAJ, Stewart KN, Thiemermann C ( 2003 ) . PPAR-gamma agonists (rosiglitazone and ciglitazone) reduce renal dysfunction and injury caused by ischaemia/reperfusion of the rat kidney . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U19 - U19 .
Dugo L, Pisano B, Wayman N, Ianaro A, Mazzon E, Caputi AP, Thiemermann C, Cuzzocrea S ( 2003 ) . PPAR-gamma ligands attenuate the development of intestinal ischemia/reperfusion . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U20 - U20 .
Cuzzocrea S, Dugo L, Di Paola R, Serraino I, Genovese T, Caputi AP, Thiemermann C ( 2003 ) . Role of PPAR-gamma ligand rosiglitazone on the development of carrageenan-induced lung injury . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U20 - U20 .
Chatterjee PK, Patel NSA, Sivarajah A, Kvale EO, Dugo L, Cuzzocrea S, Brown PAJ, Stewart KN et al. ( 2003 ) . GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury . Kidney Int vol. 63 , ( 3 ) 853 - 865 .
Thiemermann C ( 2003 ) . Protein tyrosine kinase inhibitors as novel therapeutics for systemic inflammation, shock, and organ injury . CRIT CARE MED vol. 31 , ( 2 ) 652 - 653 .
Cuzzocrea S, Ianaro A, Wayman NS, Mazzon E, Pisano B, Dugo L, Serraino I, Di Paola R et al. ( 2003 ) . The cyclopentenone prostaglandin 15-deoxy-Delta (12,14)-PGJ(2) attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat . BRIT J PHARMACOL vol. 138 , ( 4 ) 678 - 688 .
Chatterjee PK, Thiemermann C ( 2003 ) . An in vivo model of ischemia/reperfusion and inflammation of the kidneys of the rat . Methods Mol Biol vol. 225 , 223 - 237 .
Øverland G, Morath S, Yndestad A, Hartung T, Thiemermann C, Foster SJ, Smedsrød B, Mathisen Ø et al. ( 2003 ) . Lipoteichoic acid is a potent inducer of cytokine production in rat and human Kupffer cells in vitro . Surg Infect (Larchmt) vol. 4 , ( 2 ) 181 - 191 .
Thiemermann C ( 2003 ) . Membrane-permeable radical scavengers (tempol) for shock, ischemia-reperfusion injury, and inflammation . Crit Care Med . vol. 31 , S76 - S84 .
THIEMERMANN C, Chatterjee PK, McDonald MC, Wayman NS ( 2003 ) . Models of coronary artery occlusion and reperfusion for the discovery of novel antiischemic and antiinflammatory drugs for the heart . Methods Mol. Biol. vol. 225 , 199 - 208 .
McDonald MC, Izumi M, Cuzzocrea S, Thiemermann C ( 2002 ) . A novel, potent and selective inhibitor of the activity of inducible nitric oxide synthase (GW274150) reduces the organ injury in hemorrhagic shock . J Physiol Pharmacol . vol. 53 , 555 - 569 .
Sivarajah A, Chatterjee PK, Hattori Y, Brown PA, Stewart KN, Todorovic Z, Mota-Filipe H, Thiemermann C ( 2002 ) . Agonists of peroxisome-proliferator activated receptor-alpha (clofibrate and WY14643) reduce renal ischemia/reperfusion injury in the rat . Med Sci Monit vol. 8 , ( 12 ) BR532 - BR539 .
Patel NSA, Chatterjee PK, Chatterjee BE, Cuzzocrea S, Serraino I, Brown PAJ, Stewart KN, Mota-Filipe H et al. ( 2002 ) . TEMPONE reduces renal dysfunction and injury mediated by oxidative stress of the rat kidney . FREE RADICAL BIO MED vol. 33 , ( 11 ) 1575 - 1589 .
Mota-Filipe H, Sepodes B, McDonald MC, Cuzzocrea S, Pinto R, Thiemermann C ( 2002 ) . The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat . Med Sci Monit vol. 8 , ( 11 ) BR444 - BR453 .
Cuzzocrea S, Chatterjee PK, Mazzon E, McDonald MC, Dugo L, Di Paola R, Serraino I, Britti D et al. ( 2002 ) . Beneficial effects of GW274150, a novel, potent and selective inhibitor of NOS activity, in a rodent model of collagen-induced arthritis . EUR J PHARMACOL vol. 453 , ( 1 ) 119 - 129 .
Cuzzocrea S, Chatterjee PK, Mazzon E, Serraino I, Dugo L, Centorrino T, Barbera A, Ciccolo A et al. ( 2002 ) . Effects of calpain inhibitor I on multiple organ failure induced by zymosan in the rat . CRIT CARE MED vol. 30 , ( 10 ) 2284 - 2294 .
Chatterjee PK, Zacharowski K, Cuzzocrea S, Brown PAJ, Stewart KN, Mota-Filipe H, Thiemermann C ( 2002 ) . Lipoteichoic acid from Staphylococcus aureus reduces renal ischemia/reperfusion injury . Kidney Int vol. 62 , ( 4 ) 1249 - 1263 .
Thiemermann C ( 2002 ) . A vaccine to prevent infections with Staphylococcus aureus . Med Sci Monit vol. 8 , ( 9 ) LE35 - LE36 .
Chatterjee PK, Todorovic Z, Sivarajah A, Thiemermann C ( 2002 ) . Caspase and calpain inhibitors reduce the renal dysfunction caused by ischemia/reperfusion of the kidney of the rat . J AM SOC NEPHROL vol. 13 , 755A - 755A .
Chatterjee PK, Patel NSA, Kvale EO, Izumi M, McDonald MC, Thiemermann C ( 2002 ) . GW274150 REDUCES ORGAN DYSFUNCTION CAUSED BY ISCHAEMIA/REPERFUSION AND HAEMORRHAGIC SHOCK . Shock vol. 18 , ( Supplement ) 3 - 4 .
Chatterjee PK, Patel NSA, Kvale EO, Thiemermann C ( 2002 ) . GW274150 reduces renal dysfunction caused by ischemia/reperfusion of the kidney of the rat . J AM SOC NEPHROL vol. 13 , 549A - 549A .
Chatterjee PK, Sivarajah A, Todorovic Z, Thiemermann C ( 2002 ) . PPAR agonists reduce renal dysfunction caused by ischemia/reperfusion of the kidney of the rat: Comparison of PPAR alpha and PPAR gamma agonists . J AM SOC NEPHROL vol. 13 , 136A - 136A .
Izumi M, McDonald MC, Sharpe MA, Chatterjee PK, Thiemermann C ( 2002 ) . Superoxide dismutase mimetics with catalase activity reduce the organ injury in hemorrhagic shock . Shock vol. 18 , ( 3 ) 230 - 235 .
Sepodes B, McDonald MC, Pinto R, Maio R, CaneiradaSilva M, MotaFilipe H, Thiemermann C ( 2002 ) . THE EFFECT OF 5-AIQ ON THE LIVER ISCHAEMIA/REPERFUSION INJURY . Shock vol. 18 , ( Supplement )
Cuzzocrea S, Chatterjee PK, Mazzon E, Dugo L, De Sarro A, Van de Loo FAJ, Caputi AP, Thiemermann C ( 2002 ) . Role of induced nitric oxide in the initiation of the inflammatory response after postischemic injury . SHOCK . vol. 18 , 169 - 176 .
Millar CGM, Thiemermann C ( 2002 ) . Carboxy-PTIO, a scavenger of nitric oxide, selectively inhibits the increase in medullary perfusion and improves renal function in endotoxemia . Shock vol. 18 , ( 1 ) 64 - 68 .
Thiemermann C ( 2002 ) . Interactions between lipoteichoic acid and peptidoglycan from Staphylococcus aureus: a structural and functional analysis . Microbes Infect vol. 4 , ( 9 ) 927 - 935 .
Wayman NS, Ellis BL, Thiemermann C ( 2002 ) . Ligands of the peroxisome proliferator-activated receptor-PPAR-a reduce myocardial infarct size . Med Sci Monit vol. 8 , ( 7 ) BR243 - BR247 .
Wayman NS, Hattori Y, McDonald MC, Mota-Filipe H, Cuzzocrea S, Pisano B, Chatterjee PK, Thiemermann C ( 2002 ) . Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size . FASEB J vol. 16 , ( 9 ) 1027 - 1040 .
Cuzzocrea S, Mazzon E, Dugo L, Centorrino T, Ciccolo A, McDonald MC, De Sarro A, Caputi AP et al. ( 2002 ) . Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in mice . CYTOKINE vol. 18 , ( 5 ) 274 - 285 .
Dugo L, Chatterjee PK, Mazzon E, McDonald MC, Di Paola R, Fulia F, Caputi AP, Thiemermann C et al. ( 2002 ) . THE TYROSIN KINASE INHIBITOR TYRPHOSTIN AG126 REDUCES THE MULTIPLE ORGAN FAILURE INDUCED BY ZYMOSAN IN THE RAT . Shock vol. 17 , ( Supplement )
Dugo L, Chatterjee PK, Mazzon E, McDonald MC, Di Paola R, Fulia F, Caputi AP, Thiemermann C et al. ( 2002 ) . The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat . INTENS CARE MED vol. 28 , ( 6 ) 775 - 788 .
Thiemermann C ( 2002 ) . Corticosteroids and cardioprotection . NAT MED vol. 8 , ( 5 ) 453 - 455 .
Thiemermann C ( 2002 ) . Development of novel, water-soluble inhibitors of poly(adenosine 5 '-diphosphate ribose) synthetase activity for use in shock and ischemia-reperfusion injury . CRIT CARE MED vol. 30 , ( 5 ) 1163 - 1165 .
Cuzzocrea S, Mazzon E, Dugo L, Serraino I, Centorrino T, Ciccolo A, Van de Loo FAJ, Britti D et al. ( 2002 ) . Inducible nitric oxide synthase-deficient mice exhibit resistance to the acute pancreatitis induced by cerulein . SHOCK vol. 17 , ( 5 ) 416 - 422 .
Ellingsen E, Morath S, Flo T, Schromm A, Hartung T, Thiemermann C, Espevik T, Golenbock D et al. ( 2002 ) . Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14 . Med Sci Monit vol. 8 , ( 5 ) BR149 - BR156 .
Cuzzocrea S, Wayman NS, Mazzon E, Dugo L, Di Paola R, Serraino I, Britti D, Chatterjee PK et al. ( 2002 ) . The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) attenuates the development of acute and chronic inflammation . MOL PHARMACOL vol. 61 , ( 5 ) 997 - 1007 .
Ballinger A, Azooz O, Thiemermann C, Cuzzocrea S ( 2002 ) . Calpain inhibitor I and colonic inflammation induced by DNBS in the rat [2] (multiple letters) . Gut vol. 50 , ( 3 ) 440 - 441 .
Thiemermann C, Cuzzocrea S ( 2002 ) . Calpain inhibitor I and colonic inflammation induced by DNBS in the rat - Reply . GUT vol. 50 , ( 3 ) 441 - 441 .
Izumi M, McDonald MC, Thiemermann C ( 2002 ) . Effects of GW274150, a novel and potent inhibitor of the activity of inducible nitric oxide synthase on the multiple organ injury in haemorrhagic shock in the anaesthetised rat . BRIT J PHARMACOL vol. 135 ,
Chatterjee PK, Patel NSA, Kvale EO, Cuzzocrea S, Brown PAJ, Stewart KN, Mota-Filipe H, Thiemermann C ( 2002 ) . Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury . Kidney Int vol. 61 , ( 3 ) 862 - 871 .
Patel NSA, Chatterjee PK, Kvale EO, Dugo L, Cuzzocrea S, Britti D, Thiemermann C ( 2002 ) . The novel iNOS inhibitor GW274150 reduces renal dysfunction mediated by ischaemia/reperfusion of the rat and mouse kidney in vivo . BRIT J PHARMACOL . vol. 135 ,
Cuzzocrea S, Chatterjee PK, Mazzon E, McDonald MC, Dugo L, Serraino I, Caputi AP, Thiemermann C ( 2002 ) . Beneficial effects of GW274150, a novel, potent and selective inhibitor of iNOS activity, in a rodent model of collagen-induced arthritis . BRIT J PHARMACOL vol. 135 ,
Sepodes B, Pinto R, McDonald MC, Mota-Filipe H, Thiemermann C ( 2002 ) . Dithiocarbamates attenuate the organ injury and dysfunction caused by endotoxin in the rat . BRIT J PHARMACOL vol. 135 ,
Kvale EO, Patel NSA, Chatterjee PK, Sharpe MA, Thiemermann C ( 2002 ) . EUK-134 reduces oxidative stress-mediated injury and death of rat proximal tubular cells . BRIT J PHARMACOL . vol. 135 ,
Izumi M, McDonald MC, Sharpe MA, Chatterjee PK, Thiemermann C ( 2002 ) . Effects of EUK-8, a superoxide dismutase mimetic with catalase activity, on the circulatory failure and multiple organ injury in haemorrhagic shock in the anaesthetised rat . BRIT J PHARMACOL vol. 135 ,
Patel NSA, Kvale EO, Chatterjee PK, Thiemermann C ( 2002 ) . Effects of L-NIL and AE-ITU on the renal dysfunction mediated by ischaemia-reperfusion of rat kidneys in vivo . BRIT J PHARMACOL . vol. 135 ,
McDonald MC, Mota-Filipe H, Cockerill GW, Miller NE, Thiemermann C ( 2002 ) . Effects of human high-density lipoproteins (HDLs) on the multiple organ injury in haemorrhagic shock in the anaesthetised rat . BRIT J PHARMACOL vol. 135 ,
Bianca RDD, Izumi M, McDonald MC, Chatterjee PK, Thiemermann C ( 2002 ) . Pyrrolidine dithiocarbamate (PDTC) reduces the renal dysfunction associated with ischaemia-reperfusion of kidney of the rat in vivo . BRIT J PHARMACOL vol. 135 ,
Chatterjee PK, Patel NSA, Kvale EO, Thiemermann C ( 2002 ) . The PPAR-gamma ligand 15d-PGJ(2) reduces renal dysfunction and injury mediated by ischaemia/reperfusion of the rat kidney . BRIT J PHARMACOL . vol. 135 ,
Kvale EO, Patel NSA, Chatterjee PK, Sharpe MA, Thiemermann C ( 2002 ) . The SOD mimetic EUK-134 reduces oxidative stress-mediated renal dysfunction in the rat in vivo . BRIT J PHARMACOL . vol. 135 ,
Wayman NS, McDonald MC, Hattori Y, Thiemermann C ( 2002 ) . The cyclopentenone prostaglandin 15d-PGJ(2) reduces the expression of iNOS and of monocyte chemoattractant protein-1 caused by ischaemia-reperfusion in the heart . BRIT J PHARMACOL vol. 135 ,
Wayman NS, McDonald MC, Thiemermann C ( 2002 ) . The peroxisome-proliferator activator receptor-gamma ligand pioglitazone reduces infarct size caused by myocardial ischaemia and reperfusion in the rat . BRIT J PHARMACOL vol. 135 ,
Zacharowski K, Chatterjee PK, Thiemermann C ( 2002 ) . Delayed preconditioning induced by lipoteichoic acid from B-subtilis and S-aureus is not blocked by administration of 5-hydroxydecanoate . SHOCK vol. 17 , ( 1 ) 19 - 22 .
THIEMERMANN C, McDonald MC, Serraino I, Cuzzocrea S, Caputi AP, Threadgill M, Mazzon E, Dugo L ( 2002 ) . Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury . Biochem. Pharmacol. vol. 63 , 293 - 304 .
Cuzzocrea S, Chatterjee PK, Mazzon E, Dugo L, Serraino I, Britti D, Mazzullo G, Caputi AP et al. ( 2002 ) . Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation . BRIT J PHARMACOL vol. 135 , ( 2 ) 496 - 510 .
Bianca RDDV, Wayman NS, McDonald MC, Pinto A, Shape MA, Chatterjee PK, Thiemermann C ( 2002 ) . Superoxide dismutase mimetic with catalase activity, EUK-134, attenuates the multiple organ injury and dysfunction caused by endotoxin in the rat . Med Sci Monit vol. 8 , ( 1 ) BR1 - BR7 .
Wayman N, McDonald MC, Thompson AS, Threadgill MD, Thiemermann C ( 2001 ) . 5-aminoisoquinolinone, a potent inhibitor of poly (adenosine 5'-diphosphate ribose) polymerase, reduces myocardial infarct size . Eur J Pharmacol vol. 430 , ( 1 ) 93 - 100 .
THIEMERMANN C, Miller NE, McDonald MC, Cockerill GW, Mota-Filipe H, Cuzzocrea S ( 2001 ) . High density lipoproteins reduce organ injury and organ dysfunction in a rat model of hemorrhagic shock . FASEB Journal . vol. 15 , 1941 - 1952 .
Cockerill GW, McDonald MC, Mota-Filipe H, Cuzzocrea S, Miller NE, Thiemermann C ( 2001 ) . High density lipoproteins reduce organ injury and organ dysfunction in a rat model of hemorrhagic shock . FASEB J vol. 15 , ( 11 ) 1941 - 1952 .
Wang JE, Jorgensen PF, Ellingsen A, Almlof M, Thiemermann C, Foster SJ, Aasen AO, Solberg R ( 2001 ) . Peptidoglycan primes for LPS-induced release of proinflammatory cytokines in whole human blood . SHOCK vol. 16 , ( 3 ) 178 - 182 .
Zacharowski K, Berkels R, Olbrich A, Chatterjee PK, Cuzzocrea S, Foster SJ, Thiemermann C ( 2001 ) . The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shock . Crit Care Med vol. 29 , ( 8 ) 1599 - 1608 .
McDonald MC, Mota-Filipe H, Abdelrahman M, Threadgill M, Thiemermann C ( 2001 ) . Discovery of 5-aminoisocoumarin as a novel inhibitor of the activity of poly (ADP-ribose) polymerase, which inhibits the multiple organ failure in haemorrhagic shock . FUNDAMENTAL & CLINICAL PHARMACOLOGY vol. 15 , 153 - 153 .
Cuzzocrea S, Dugo L, Mazzon E, De Sarro A, Caputi AP, Thiemermann C ( 2001 ) . Inducible nitric oxide synthase regulate the initiation of the inflammatory response after postischemic injury . FUNDAMENTAL & CLINICAL PHARMACOLOGY vol. 15 , 88 - 88 .
Thiemermann C, Wayman NS ( 2001 ) . Menarini Academy Cardiovascular Research Awards in Basic Science 2001: ligands of the orphan receptor peroxisome-proliferator activator-gamma reduce myocardial infarct size . Med Sci Monit vol. 7 , ( 4 ) 787 - 789 .
Sepodes B, Mota-Filipe H, Pinto R, McDonald MC, Thiemermann C ( 2001 ) . Pretreatment of rats with hemoglobin reduces the multiple organ dysfunction associated with endotoxic shock . FUNDAMENTAL & CLINICAL PHARMACOLOGY vol. 15 , 85 - 85 .
Wayman NS, McDonald MC, Thiemermann C ( 2001 ) . Reduction of myocardial infarct size by ligands (15d-PGJ(2), ciglitazone and rosiglitazone) for the peroxisome-proliferator activator receptor-gamma (PPAR-gamma) . FUNDAMENTAL & CLINICAL PHARMACOLOGY vol. 15 , 87 - 87 .
Chatterjee PK, Patel N, Kvale E, Thiemermann C ( 2001 ) . The tyrosine kinase inhibitor Tyrphostin AG126 reduces the renal dysfunction associated with ischaemia/reperfusion of rat kidneys in vivo . FUNDAMENTAL & CLINICAL PHARMACOLOGY vol. 15 , 70 - 70 .
Thiemermann C ( 2001 ) . Aminoethyl-isothiourea in gram-positive shock: An inhibitor of inducible nitric oxide synthase or a jack-of-all-trades? . SHOCK vol. 15 , ( 6 ) 453 - 454 .
Chatterjee PK, Brown PAJ, Cuzzocrea S, Zacharowski K, Stewart KN, Mota-Filipe H, McDonald MC, Thiemermann C ( 2001 ) . Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat . KIDNEY INT vol. 59 , ( 6 ) 2073 - 2083 .
McDonald MC, MotaFilipe H, Cockerill GW, Cuzzocrea S, Miller NE, Thiemermann C, Chaudry I ( 2001 ) . HUMAN RECONSTITUTED HIGH-DENSITY LIPOPROTEIN ATTENUATES THE MULTIPLE ORGAN INJURY AND DYSFUNCTION IN HEMORRHAGIC SHOCK . Shock vol. 15 , ( Supplement )
MotaFilipe H, Sepodes B, Pinto R, McDonald MC, Thiemermann C, Chaudry I ( 2001 ) . PRETREATMENT OF RATS WITH HEMOGLOBIN REDUCES THE MULTIPLE ORGAN INJURY CAUSED BY ENDOTOXIN . Shock vol. 15 , ( Supplement )
Cuzzocrea S, Dugo L, Mazzon E, De Sarro A, Caputi AP, Thiemermann C ( 2001 ) . ROLE OF INDUCIBLE NITRIC OXIDE SYNTHASE IN THE INITIATION OF THE INFLAMMATORY RESPONSE AFTER POSTISCHEMIC INJURY . Shock vol. 15 , ( Supplement )
Zacharowski K, Chatterjee PK, Thiemermann C ( 2001 ) . Different wall fragments of gram-positive or negative bacteria induce delayed preconditioning in the rat heart in vivo . BRIT J PHARMACOL vol. 133 , U6 - U6 .
Wayman NS, Thiemermann C ( 2001 ) . Effects of 15-deoxy-D12, 14-prostaglandin J2 on the infarct size caused by myocardial ischaemia and reperfusion in the rat . BRIT J PHARMACOL vol. 133 , U64 - U64 .
Wayman NS, McDonald MC, Threadgill MD, Thiemermann C ( 2001 ) . Effects of 5-aminoisoquinolinone regional myocardial ischaemia and reperfusion in the anaesthetised rat . BRIT J PHARMACOL vol. 133 ,
Cuzzocrea S, McDonald MC, Mazzon E, Dugo L, Mota-Filipe H, Caputi AP, Thiemermann C ( 2001 ) . Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on P-selectin and intercellular adhesion molecule-1 in lung injury . BRIT J PHARMACOL vol. 133 , U24 - U24 .
Abdelrahman M, McDonald MC, Wayman NS, Thiemermann C ( 2001 ) . Effects of L-N-(L-iminoethyl)lysine (L-NIL) on the circulatory failure and multiple organ injury in haemorrhagic shock in the anaesthetised rat . BRIT J PHARMACOL vol. 133 , U63 - U63 .
Abdelrahman M, McDonald MC, Cuzzocrea S, Thiemermann C ( 2001 ) . Effects of tyrphostin AG126 on the multiple organ failure caused by severe haemorrhage and resuscitation in the anaesthetised rat . BRIT J PHARMACOL vol. 133 , U63 - U63 .
Thiemermann C ( 2001 ) . Inhaled CO: Deadly gas or novel therapeutic? . NAT MED vol. 7 , ( 5 ) 534 - 535 .
Jorgensen PF, Wang JE, Almlof M, Thiemermann C, Foster SJ, Solberg R, Aasen AO ( 2001 ) . Peptidoglycan and lipoteichoic acid modify monocyte phenotype in human whole blood . CLIN DIAGN LAB IMMUN vol. 8 , ( 3 ) 515 - 521 .
Zacharowski K, Frank S, Thiemermann C ( 2001 ) . Role of nitric oxide on the delayed cardioprotection afforded by lipopolysaccharide in the rat heart in vivo . BRIT J PHARMACOL vol. 133 ,
Chatterjee PK, Pedersen H, Chatterjee BE, McDonald MC, Thomson AS, Threadgill MD, Thiemermann C ( 2001 ) . The poly(ADP-ribose) polymerase inhibitor 5-aminoisoquinoline reduces oxidative stress-mediated renal dysfunction in the rat in vivo and in vitro . BRIT J PHARMACOL vol. 133 , U65 - U65 .
Patel N, Chatterjee PK, Chatterjee BE, Thiemermann C ( 2001 ) . The stable nitroxyl radical tempone reduces oxidative stress-mediated renal dysfunction in the rat in vivo and in vitro . BRIT J PHARMACOL . vol. 133 , U9 - U9 .
Zacharowski K, Blackburn B, Thiemermann C ( 2001 ) . Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat . Eur J Pharmacol vol. 418 , ( 1-2 ) 105 - 110 .
Cuzzocrea S, McDonald MC, Mazzon E, Mota-Filipe H, Centorrino T, Terranova ML, Ciccolo A, Britti D et al. ( 2001 ) . Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the rat . GUT vol. 48 , ( 4 ) 478 - 488 .
Thiemermann C, Spies C, Radermacher P, Briegel J ( 2001 ) . Neue ansätze der therapie mit vasoaktiven substanzen bei sepsis und multiorgandysfunktion-syndrom . Intensivmedizin und Notfallmedizin vol. 38 , ( 2 ) 128 - 137 .
Wray GM, Foster SJ, Hinds CJ, Thiemermann C ( 2001 ) . A cell wall component from pathogenic and non-pathogenic gram-positive bacteria (peptidoglycan) synergises with endotoxin to cause the release of tumour necrosis factor-alpha, nitric oxide production, shock, and multiple organ injury/dysfunction in the rat . Shock vol. 15 , ( 2 ) 135 - 142 .
Thiemermann C ( 2001 ) . Globale und regionale zirkulationsstörungen bei sepsis und multiorgandysfunktions-syndrom (MODS) . Intensivmedizin und Notfallmedizin vol. 38 , ( 1 ) 31 - 38 .
Jørgensen PF, Wang JE, Solberg R, Thiemermann C, Foster SJ, Aasen AO ( 2001 ) . Procalcitonin does not influence the surface expression of inflammatory receptors on whole blood leukocytes . Intensive Care Med vol. 27 , ( 2 ) 430 - 433 .
Jorgensen PF, Wang JE, Almlof M, Solberg R, Okkenhaug C, Scholz T, Thiemermann C, Foster SJ et al. ( 2001 ) . Sirolimus interferes with the innate response to bacterial products in human whole blood by attenuation of IL-10 production . SCAND J IMMUNOL vol. 53 , ( 2 ) 184 - 191 .
Cuzzocrea S, McDonald MC, Mazzon E, Filipe HM, Centorrino T, Lepore V, Terranova ML, Ciccolo A et al. ( 2001 ) . Beneficial effects of tempol, a membrane-permeable radical scavenger, on the multiple organ failure induced by zymosan in the rat . CRIT CARE MED vol. 29 , ( 1 ) 102 - 111 .
McDonald MC, Mota-Filipe H, Paul A, Cuzzocrea S, Abdelrahman M, Harwood S, Plevin R, Chatterjee PK et al. ( 2001 ) . Calpain inhibitor I reduces the activation of nuclear factor-kappaB and organ injury/dysfunction in hemorrhagic shock . FASEB J vol. 15 , ( 1 ) 171 - 186 .
Thiemermann C ( 2001 ) . Nitric oxide and circulatory shock: An update . NITRIC OXIDE . Editors: Gryglewski, RJ, Minuz, P , vol. 317 , 117 - 125 .
Thiemermann C, McDonald MC, Cuzzocrea S ( 2001 ) . The stable nitroxide, tempol, attenuates the effects of peroxynitrite and oxygen-derived free radicals . CRIT CARE MED vol. 29 , ( 1 ) 223 - 224 .
Cuzzocrea S, McDonald MC, Mazzon E, Dugo L, Lepore V, Fonti MT, Ciccolo A, Terranova ML et al. ( 2000 ) . Tempol, a membrane-permeable radical scavenger, reduces dinitrobenzene sulfonic acid-induced colitis . European Journal of Pharmacology vol. 406 , ( 1 ) 127 - 137 .
Cuzzocrea S, McDonald MC, Mazzon E, Siriwardena D, Costantino G, Fulia F, Cucinotta G, Gitto E et al. ( 2000 ) . Effects of tempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury . Brain Research vol. 875 , ( 1-2 ) 96 - 106 .
Cuzzocrea S, McDonald MC, Mazzon E, Filipe HM, Costantino G, Caputi AP, Thiemermann C ( 2000 ) . Beneficial effects of tempol, a membrane-permeable radical scavenger, in a rodent model of splanchnic artery occlusion and reperfusion . SHOCK vol. 14 , ( 2 ) 150 - 156 .
Thiemermann C ( 2000 ) . Inhibition of the activity of poly (ADP-ribose) polymerase in ischemia-reperfusion injury - Editorial comment . SHOCK vol. 14 , ( 2 ) 142 - 143 .
Chatterjee PK, Cuzzocrea S, Brown PA, Zacharowski K, Stewart KN, Mota-Filipe H, Thiemermann C ( 2000 ) . Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat . Kidney Int vol. 58 , ( 2 ) 658 - 673 .
Wang JE, JØrgensen PF, Almlöf M, Thiemermann C, Foster SJ, Aasen AO, Solberg R ( 2000 ) . Peptidoglycan and lipoteichoic acid from Staphylococcus aureus induce tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-10 production in both T cells and monocytes in a human whole blood model . Infection and Immunity vol. 68 , ( 7 ) 3965 - 3970 .
Thiemermann C, Zacharowski K ( 2000 ) . Selective activation of E-type prostanoid<inf>3</inf>-receptors reduces myocardial infarct size: A novel insight into the cardioprotective effects of prostaglandins . Pharmacology and Therapeutics vol. 87 , ( 1 ) 61 - 67 .
Dhadly P, McDonald MC, Cockerill G, Hinds CJ, Miller NE, Thiemermann C ( 2000 ) . Pre-treatment with high density lipoprotein (HDL) attenuates the renal and hepatic dysfunction caused by endotoxin in rats . British Journal of Anaesthesia vol. 84 , ( 5 ) 688 - 688 .
Walpen S, Beck KF, Eberhardt W, Apel M, Chatterjee PK, Wray GMH, Thiemermann C, Pfeilschifter J ( 2000 ) . Downregulation of SPARC expression is mediated by nitric oxide in rat mesangial cells and during endotoxemia in the rat . Journal of the American Society of Nephrology vol. 11 , ( 3 ) 468 - 476 .
Cuzzocrea S, McDonald MC, Filipe HM, Costantino G, Mazzon E, Santagati S, Caputi AP, Thiemermann C ( 2000 ) . Effects of tempol, a membrane-permeable radical scavenger, in a rodent model of carrageenan-induced pleurisy . European Journal of Pharmacology vol. 390 , ( 1-2 ) 209 - 222 .
Cuzzocrea S, Mcdonald MC, Mota-Filipe H, Mazzon E, Costantino G, Britti D, Mazzullo G, Caputi AP et al. ( 2000 ) . Beneficial effects of tempol, a membrane-permeable radical scavenger, in a rodent model of collagen-induced arthritis . Arthritis and Rheumatism vol. 43 , ( 2 ) 320 - 328 .
McDonald MC, Mota-Filipe H, Wright JA, Abdelrahman M, Threadgill MD, Thompson AS, Thiemermann C ( 2000 ) . Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock . British Journal of Pharmacology vol. 130 , ( 4 ) 843 - 850 .
Chatterjee PK, Zacharowski K, Cuzzocrea S, Otto M, Thiemermann C ( 2000 ) . Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia- reperfusion injury in the anesthetized rat in vivo . FASEB Journal vol. 14 , ( 5 ) 641 - 651 .
Zacharowski K, Frank S, Otto M, Chatterjee PK, Cuzzocrea S, Hafner G, Pfeilschifter J, Thiemermann C ( 2000 ) . Lipoteichoic acid induces delayed protection in the rat heart: A comparison with endotoxin . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 20 , ( 6 ) 1521 - 1528 .
Zacharowski K, Olbrich A, Cuzzocrea S, Foster SJ, Thiemermann C ( 2000 ) . Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of Gram-positive shock . Critical Care Medicine vol. 28 , ( 6 ) 1953 - 1961 .
Thiemermann C ( 2000 ) . New therapeutic approaches: Nitric oxide synthase inhibitors . Anasthesiologie und Intensivmedizin vol. 41 , ( 7-8 ) 614 - 615 .
Cuzzocrea S, McDonald MC, Mazzon E, Mota-Filipe H, Lepore V, Ciccolo A, Terranova ML, Britti D et al. ( 2000 ) . The tyrosine kinase inhibitor Tyrphostin AG 126 reduces the development of colitis in the rat . Laboratory Investigation vol. 80 , ( 9 ) 1439 - 1453 .
Thiemermann C ( 2000 ) . The use of haemodynamically active substances in sepsis and multi-organ dysfunction syndrome (MODS): Global and regional circulatory disturbance . Anasthesiologie und Intensivmedizin vol. 41 , ( 7-8 ) 585 - 592 .
Zacharowski K, Otto M, Hafner G, Marsh HC, Thiemermann C ( 1999 ) . Reduction of myocardial infarct size with sCR1sLe(x), an alternatively glycosylated form of human soluble complement receptor type 1 (sCR1), possessing sialyl Lewis x . British Journal of Pharmacology vol. 128 , ( 5 ) 945 - 952 .
Cuzzocrea S, Sautebin L, De Sarro G, Costantino G, Rombolà L, Mazzon E, Ialenti A, De Sarro A et al. ( 1999 ) . Role of IL-6 in the pleurisy and lung injury caused by carageenan . Journal of Immunology vol. 163 , ( 9 ) 5094 - 5104 .
McDonald MC, Zacharowski K, Bowes J, Cuzzocrea S, Thiemermann C ( 1999 ) . Tempol reduces infarct size in rodent models of regional myocardial ischemia and reperfusion . Free Radical Biology and Medicine vol. 27 , ( 5-6 ) 493 - 503 .
Docherty JC, Kuzio B, Silvester JA, Bowes J, Thiemermann C ( 1999 ) . An inhibitor of poly (ADP-ribose) synthetase activity reduces contractile dysfunction and preserves high energy phosphate levels during reperfusion of the ischaemic rat heart . British Journal of Pharmacology vol. 127 , ( 6 ) 1518 - 1524 .
Ruetten H, Thiemermann C, Perretti M ( 1999 ) . Upregulation of ICAM-1 expression on J774.2 macrophages by endotoxin involves activation of NF-κB but not protein tyrosine kinase: Comparison to induction of iNOS . Mediators of Inflammation vol. 8 , ( 2 ) 77 - 84 .
Zacharowski K, Olbrich A, Thiemermann C ( 1999 ) . Reduction of myocardial injury by the EP<inf>3</inf> receptor agonist TEI-3356. Role of protein kinase C and of K(ATP)-channels . European Journal of Pharmacology vol. 367 , ( 1 ) 33 - 39 .
Mota-Filipe H, McDonald MC, Cuzzocrea S, Thiemermann C ( 1999 ) . A membrane-permeable radical scavenger reduces the organ injury in hemorrhagic shock . Shock vol. 12 , ( 4 ) 255 - 261 .
McDonald MC, Filipe HM, Thiemermann C ( 1999 ) . Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock . British Journal of Pharmacology vol. 128 , ( 6 ) 1339 - 1345 .
Zacharowski K, Olbrich A, Otto M, Hafner G, Thiemermann C ( 1999 ) . Effects of the prostanoid EP<inf>3</inf>-receptor agonists M and B 28767 and GR 63799X on infarct size caused by regional myocardial ischaemia in the anaesthetized rat . British Journal of Pharmacology vol. 126 , ( 4 ) 849 - 858 .
Zacharowski K, Otto M, Hafner G, Chatterjee PK, Thiemermann C ( 1999 ) . Endotoxin induces a second window of protection in the rat heart as determined by using p-nitro-blue tetrazolium staining, cardiac troponin T release, and histology . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 19 , ( 9 ) 2276 - 2280 .
Frank S, Zacharowski K, Wray GM, Thiemermann C, Pfeilschifter J ( 1999 ) . Identification of copper/zinc superoxide dismutase as a novel nitric oxide-regulated gene in rat glomerular mesangial cells and kidneys of endotoxemic rats . FASEB Journal vol. 13 , ( 8 ) 869 - 882 .
Bowes J, McDonald MC, Piper J, Thiemermann C ( 1999 ) . Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress . Cardiovascular Research vol. 41 , ( 1 ) 126 - 134 .
Chatterje PK, Cuzzocrea S, Thiemermann C ( 1999 ) . Inhibitors of poly (ADP-ribose) synthetase protect rat proximal tubular cells against oxidant stress . Kidney International vol. 56 , ( 3 ) 973 - 984 .
Thiemermann C, Warner TD ( 1999 ) . Nitric oxide and endothelin-1 in circulatory shock involving cytokines . Cytokines in Severe Sepsis and Septic Shock ,
Zacharowski K, Thiemermann C ( 1999 ) . Pharmacology of the prostaglandin EP<inf>3</inf> receptor agonist TEI-3356 . Cardiovascular Drug Reviews vol. 17 , ( 4 ) 329 - 340 .
Zacharowski K, Olbrich A, Piper J, Hafner G, Kondo K, Thiemermann C ( 1999 ) . Selective activation of the prostanoid EP<inf>3</inf> receptor reduces myocardial infarct size in rodents . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 19 , ( 9 ) 2141 - 2147 .
Olbrich A, Zacharowski K, Thiemermann C ( 1998 ) . P54 the cell injury and death caused by hydrogen peroxide in human cardiomyoblasts is reduced by the EP<inf>3</inf>-receptor agonist ONO-AE-248 . Fibrinolysis and Proteolysis vol. 12 , ( SUPPL. 2 )
Leach M, Frank S, Olbrich A, Pfeilschifter J, Thiemermann C ( 1998 ) . Decline in the expression of copper/zinc superoxide dismutase in the kidney of rats with endotoxic shock: Effects of the superoxide anion radical scavenger, tempol, on organ injury . British Journal of Pharmacology vol. 125 , ( 4 ) 817 - 825 .
Bowes J, Ruetten H, Martorana PA, Stockhausen H, Thiemermann C ( 1998 ) . Reduction of myocardial reperfusion injury by an inhibitor of poly (ADP-ribose) synthetase in the pig . European Journal of Pharmacology vol. 359 , ( 2-3 ) 143 - 150 .
Bowes J, Piper J, Thiemermann C ( 1998 ) . Inhibitors of the activity of poly (ADP-ribose) synthetase reduce the cell death caused by hydrogen peroxide in human cardiac myoblasts . British Journal of Pharmacology vol. 124 , ( 8 ) 1760 - 1766 .
Kengatharan KM, De Kimpe S, Robson C, Foster S, Thiemermann C ( 1998 ) . Mechanism of gram-positive shock: identification of peptidoglycan and lipoteichoic acid moieties essential in the induction of nitric oxide synthase, shock, and multiple organ failure . Journal of Experimental Medicine vol. 188 , ( 2 ) 305 - 315 .
Leach M, Hamilton LC, Olbrich A, Wray GM, Thiemermann C ( 1998 ) . Effects of inhibitors of the activity of cyclo-oxygenase-2 on the hypotension and multiple organ dysfunction caused by endotoxin: A comparison with dexamethasone . British Journal of Pharmacology vol. 124 , ( 3 ) 586 - 592 .
Hattori Y, Kasai K, Nakanishi N, Gross SS, Thiemermann C ( 1998 ) . Induction of nitric oxide and tetrahydrobiopterin synthesis by lipoteichoic acid from Staphylococcus aureus in vascular smooth muscle cells . Journal of Vascular Research vol. 35 , ( 2 ) 104 - 108 .
Sætre T, Gundersen Y, Thiemermann C, Lilleaasen P, Aasen AO ( 1998 ) . Aminoethyl-isothiourea, a selective inhibitor of inducible nitric oxide synthase activity, improves liver circulation and oxygen metabolism in a porcine model of endotoxemia . Shock vol. 9 , ( 2 ) 109 - 115 .
Wray GM, Hinds CJ, Thiemermann C ( 1998 ) . Cell wall fragments from Gram positive and Gram negative bacteria synergize to cause organ failure in the rat . British Journal of Anaesthesia . vol. 80 , 542 - 543 .
Wray GM, Hinds CJ, Thiemermann C ( 1998 ) . Effects of inhibitors of poly(ADP-ribose) synthetase activity on hypotension and multiple organ dysfunction caused by endotoxin . Shock vol. 10 , ( 1 ) 13 - 19 .
Bowes J, Thiemermann C ( 1998 ) . Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the liver injury caused by ischaemia-reperfusion: A comparison with radical scavengers . British Journal of Pharmacology vol. 124 , ( 6 ) 1254 - 1260 .
Chatterjee PK, Thiemermann C ( 1998 ) . Inhibitors of poly (ADP-ribose) synthetase protect rat renal proximal tubular cells against oxidant stress . Biochemical Society Transactions vol. 26 , ( 4 )
Bani D, Failli P, Bello MG, Thiemermann C, Sacchi TB, Bigazzi M, Masini E ( 1998 ) . Relaxin activates the L-arginine-nitric oxide pathway in vascular smooth muscle cells in culture . Hypertension vol. 31 , ( 6 ) 1240 - 1247 .
Wray GM, Millar CG, Hinds CJ, Thiemermann C ( 1998 ) . Selective inhibition of the activity of inducible nitric oxide synthase prevents the circulatory faolure, but not the organ injury/dysfunction, caosed by endotoxin . Shock vol. 9 , ( 5 ) 329 - 335 .
Thiemermann C ( 1998 ) . The Use of Selective Inhibitors of Inducible Nitric Oxide Synthase in Septic Shock . Sepsis vol. 1 , ( 2 ) 123 - 129 .
Ruetten H, Thiemermann C ( 1997 ) . Combination immunotherapy which neutralises the effects of TNFα and IL- 1β attenuates the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat . Journal of Physiology and Pharmacology . vol. 48 , 605 - 621 .
Ruetten H, Thiemermann C ( 1997 ) . Endothelin-1 stimulates the biosynthesis of tumour necrosis factor in macrophages: ET-receptors, signal transduction and inhibition by dexamethasone . Journal of Physiology and Pharmacology . vol. 48 , 675 - 688 .
Ruetten H, Thiemermann C ( 1997 ) . Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: A possible role for protein tyrosine kinase . British Journal of Pharmacology vol. 122 , ( 1 ) 59 - 70 .
Millar CGM, Thiemermann C ( 1997 ) . Intrarenal haemodynamics and renal dysfunction in endotoxaemia: Effects of nitric oxide synthase inhibition . British Journal of Pharmacology vol. 121 , ( 8 ) 1824 - 1830 .
Thiemermann C ( 1997 ) . Nitric oxide and septic shock . General Pharmacology vol. 29 , ( 2 ) 159 - 166 .
Ruetten H, Thiemermann C ( 1997 ) . Effect of calpain inhibitor I, an inhibitor of the proteolysis of IκB, on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat . British Journal of Pharmacology vol. 121 , ( 4 ) 695 - 704 .
Hattor Y, Kasai K, Akimoto K, Thiemermann C ( 1997 ) . Induction of NO synthesis by lipoteichoic acid from Staphylococcus aureus in J774 macrophages: Involvement of a CD14-dependent pathway . Biochemical and Biophysical Research Communications vol. 233 , ( 2 ) 375 - 379 .
Thiemermann C, Bowes J, Myint FP, Vane JR ( 1997 ) . Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle . Proceedings of the National Academy of Sciences of the United States of America vol. 94 , ( 2 ) 679 - 683 .
Ruetten H, Thiemermann C ( 1997 ) . Interleukin-13 is a more potent inhibitor of the expression of inducible nitric oxide synthase in smooth muscle cells than in macrophages: A comparison with interleukin-4 and interleukin-10 . Shock vol. 8 , ( 6 ) 409 - 414 .
Thiemermann C ( 1996 ) . The role of nitric oxide for the regulation of vascular tone in health and disease . Korean Journal of Physiology vol. 30 , ( 2 ) 187 - 195 .
Ruetten H, Thiemermann C ( 1996 ) . Prevention of the expression of inducible nitric oxide synthase by aminoguanidine or aminoethyl-isothiourea in macrophages and in the rat . Biochemical and Biophysical Research Communications vol. 225 , ( 2 ) 525 - 530 .
Hide EJ, Thiemermann C ( 1996 ) . Limitation of myocardial infarct size in the rabbit by ischaemic preconditioning is abolished by sodium 5-hydroxydecanoate . Cardiovascular Research vol. 31 , ( 6 ) 941 - 946 .
Wu CC, Ruetten H, Thiemermann C ( 1996 ) . Comparison of the effects of aminoguanidine and N<sup>ω</sup>-nitro-L-arginine methyl ester on the multiple organ dysfunction caused by endotoxaemia in the rat . European Journal of Pharmacology vol. 300 , ( 1-2 ) 99 - 104 .
Akarasereenont P, Thiemermann C ( 1996 ) . The induction of cyclo-oxygenase-2 in human pulmonary epithelial cell culture (A549) activated by IL-1β is inhibited by tyrosine kinase inhibitors . Biochemical and Biophysical Research Communications vol. 220 , ( 1 ) 181 - 185 .
Kengatharan M, De Kimpe SJ, Thiemermann C ( 1996 ) . Analysis of the signal transduction in the induction of nitric oxide synthase by lipoteichoic acid in macrophages . British Journal of Pharmacology vol. 117 , ( 6 ) 1163 - 1170 .
Ruetten H, Southan GJ, Abate A, Thiemermann C ( 1996 ) . Attenuation of endotoxin-induced multiple organ dysfunction by 1-amino-2-hydroxy-guanidine, a potent inhibitor of inducible nitric oxide synthase . British Journal of Pharmacology vol. 118 , ( 2 ) 261 - 270 .
Wu CC, Thiemermann C ( 1996 ) . Biological control and inhibition of induction of nitric oxide synthase . Methods in Enzymology vol. 268 , 408 - 420 .
Wood PJ, Sansom JM, Stratford IJ, Adams GE, Szabo C, Thiemermann C, Vane JR ( 1996 ) . Changes in energy metabolism and X-ray sensitivity in murine tumours by the nitric oxide donor SIN-1 . British Journal of Cancer . vol. 74 ,
Ruetten H, Thiemermann C ( 1996 ) . Effect of selective blockade of endothelin ET(B) receptors on the liver dysfunction and injury caused by endotoxaemia in the rat . British Journal of Pharmacology vol. 119 , ( 3 ) 479 - 486 .
Ruetten H, Thiemermann C, Vane JR ( 1996 ) . Effects of the endothelin receptor antagonist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rat . British Journal of Pharmacology vol. 118 , ( 1 ) 198 - 204 .
Cristol JP, Thiemermann C, Guerin MC, Torreilles J, Crastes de Paulet A ( 1996 ) . L-Arginine infusion after ischaemia-reperfusion of rat kidney enhances lipid peroxidation . Journal of Lipid Mediators and Cell Signalling vol. 13 , ( 1 ) 9 - 17 .
Millar CGM, Baxter GF, Thiemermann C ( 1996 ) . Protection of the myocardium by ischaemic preconditioning: Mechanisms and therapeutic implications . Pharmacology and Therapeutics vol. 69 , ( 2 ) 143 - 151 .
Ogata H, Luo XX, Szabo C, Thiemermann C ( 1996 ) . Role of nitric oxide in hemorrhagic shock . Anesthesia and Resuscitation vol. 32 , ( 1 ) 19 - 27 .
Kengatharan KM, De Kimpe SJ, Thiemermann C ( 1996 ) . Role of nitric oxide in the circulatory failure and organ injury in a rodent model of Gram-positive shock . British Journal of Pharmacology vol. 119 , ( 7 ) 1411 - 1421 .
Hide EJ, Thiemermann C ( 1996 ) . Sulprostone-induced reduction of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels . British Journal of Pharmacology vol. 118 , ( 6 ) 1409 - 1414 .
Thiemermann C ( 1995 ) . Inhibition of nitric oxide synthase activity in circulatory shock: Friend or foe? . Medecine/Sciences vol. 11 , ( 12 ) 1643 - 1651 .
Southan GJ, Szabó C, O'Connor MP, Salzman AL, Thiemermann C ( 1995 ) . Amidines are potent inhibitors of nitric oxide synthases: preferential inhibition of the inducible isoform . European Journal of Pharmacology: Molecular Pharmacology vol. 291 , ( 3 ) 311 - 318 .
De Kimpe SJ, Kengatharan M, Thiemermann C, Vane JR ( 1995 ) . The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure . Proceedings of the National Academy of Sciences of the United States of America vol. 92 , ( 22 ) 10359 - 10363 .
Hattori Y, Szabó C, Gross SS, Thiemermann C, Vane JR ( 1995 ) . Lipid A and the lipid A analogue anti-tumour compound ONO-4007 induce nitric oxide synthese in vitro and in vivo . European Journal of Pharmacology: Molecular Pharmacology vol. 291 , ( 2 ) 83 - 90 .
Wu CC, Croxtall JD, Perretti M, Bryant CE, Thiemermann C, Flower RJ, Vane JR ( 1995 ) . Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat . Proceedings of the National Academy of Sciences of the United States of America vol. 92 , ( 8 ) 3473 - 3477 .
Akarasereenont P, Mitchell JA, Bakhle YS, Thiemermann C, Vane JR ( 1995 ) . Comparison of the induction of cyclooxygenase and nitric oxide synthase by endotoxin in endothelial cells and macrophages . European Journal of Pharmacology vol. 273 , ( 1-2 ) 121 - 128 .
Wu C, Chen S, Szabó C, Thiemermann C, Vane JR ( 1995 ) . Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock . British Journal of Pharmacology vol. 114 , ( 8 ) 1666 - 1672 .
Akarasereenont P, Bakhle YS, Thiemermann C, Vane JR ( 1995 ) . Cytokine‐mediated induction of cyclo‐oxygenase‐2 by activation of tyrosine kinase in bovine endothelial cells stimulated by bacterial lipopolysaccharide . British Journal of Pharmacology vol. 115 , ( 3 ) 401 - 408 .
De Kimpe SJ, Hunter ML, Bryant CE, Thiemermann C, Vane JR ( 1995 ) . Delayed circulatory failure due to the induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in anaesthetized rats . British Journal of Pharmacology vol. 114 , ( 6 ) 1317 - 1323 .
Perretti M, Szabó C, Thiemermann C ( 1995 ) . Effect of interleukin‐4 and interleukin‐10 on leucocyte migration and nitric oxide production in the mouse . British Journal of Pharmacology vol. 116 , ( 4 ) 2251 - 2257 .
Klemm P, Thiemermann C, Winklmaier G, Martorana PA, Henning R ( 1995 ) . Effects of nitric oxide synthase inhibition combined with nitric oxide inhalation in a porcine model of endotoxin shock . British Journal of Pharmacology vol. 114 , ( 2 ) 363 - 368 .
Kengatharan M, Battistini B, Warner TD, Thiemermann C, Vane JR ( 1995 ) . Endothelin-1 mediates the increase in ex vivo coronary vascular resistance induced by hemorrhagic shock in the anesthetized rat . Journal of Cardiovascular Pharmacology . vol. 26 , S422 - S424 .
Hide EJ, Piper J, Thiemermann C ( 1995 ) . Endothelin‐1 ‐induced reduction of myocardial infarct size by activation of ATP‐sensitive potassium channels in a rabbit model of myocardial ischaemia and reperfusion . British Journal of Pharmacology vol. 116 , ( 6 ) 2597 - 2602 .
Wu C, Thiemermann C, Vane JR ( 1995 ) . Glibenclamide‐induced inhibition of the expression of inducible nitric oxide synthase in cultured macrophages and in the anaesthetized rat . British Journal of Pharmacology vol. 114 , ( 6 ) 1273 - 1281 .
Klemm P, Hecker M, Stockhausen H, Wu CC, Thiemermann C ( 1995 ) . Inhibition by N‐acetyl‐5‐hydroxytryptamine of nitric oxide synthase expression in cultured cells and in the anaesthetized rat . British Journal of Pharmacology vol. 115 , ( 7 ) 1175 - 1181 .
Southan GJ, Szabó C, Thiemermann C ( 1995 ) . Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity . British Journal of Pharmacology vol. 114 , ( 2 ) 510 - 516 .
Bryant CE, Tomlinson A, Mitchell JA, Thiemermann C, Willoughby DA ( 1995 ) . Nitric oxide synthase in the rat fallopian tube is regulated during the oestrous cycle . Journal of Endocrinology vol. 146 , ( 1 ) 149 - 157 .
Hide EJ, Ney P, Piper J, Thiemermann C, Vane JR ( 1995 ) . Reduction by prostaglandin E<inf>1</inf> or prostaglandin E<inf>0</inf> of myocardial infarct size in the rabbit by activation of ATP‐sensitive potassium channels . British Journal of Pharmacology vol. 116 , ( 5 ) 2435 - 2440 .
Szabó C, Thiemermann C ( 1995 ) . Regulation of the Expression of the Inducible Isoform of Nitric Oxide Synthase . Advances in Pharmacology vol. 34 , ( C ) 113 - 153 .
De Kimpe SJ, Thiemermann C, Vane JR ( 1995 ) . Role for intracellular platelet‐activating factor in the circulatory failure in a model of Gram‐positive shock . British Journal of Pharmacology vol. 116 , ( 8 ) 3191 - 3198 .
Thiemermann C ( 1995 ) . Selective inhibition of the activity of inducible nitric oxide synthase in septic shock . Progress in clinical and biological research vol. 392 , 383 - 392 .
Hohlfeld T, Klemm P, Thiemermann C, Warner TD, Schrör K, Vane JR ( 1995 ) . The contribution of tumour necrosis factor‐α and endothelin‐1 to the increase of coronary resistance in hearts from rats treated with endotoxin . British Journal of Pharmacology vol. 116 , ( 8 ) 3309 - 3315 .
Akarasereenont P, Hide E, Ney P, Thiemermann C, Vane JR ( 1995 ) . The induction of cyclooxygenase-2 elicited by endotoxin in endothelial cells and macrophages is inhibited by prostaglandin E<inf>1</inf> and 13,14-dihydro prostaglandin E<inf>1</inf> . Agents and Actions . vol. 45 , 59 - 64 .
Thiemermann C, Ruetten H, Wu C, Vane JR ( 1995 ) . The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase . British Journal of Pharmacology vol. 116 , ( 7 ) 2845 - 2851 .
Szabó C, Southan GJ, Thiemermann C ( 1994 ) . Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase . Proceedings of the National Academy of Sciences of the United States of America vol. 91 , ( 26 ) 12472 - 12476 .
Southan GJ, Szabó C, Thiemermann C ( 1994 ) . Inhibition of the induction of nitric oxide synthase by spermine is modulated by aldehyde dehydrogenase . Biochemical and Biophysical Research Communications vol. 203 , ( 3 ) 1638 - 1644 .
McMurdo L, Thiemermann C, Vane JR ( 1994 ) . The endothelin ET<inf>B</inf> receptor agonist, IRL 1620, causes vasodilation and inhibits ex vivo platelet aggregation in the anaesthetised rabbit . European Journal of Pharmacology vol. 259 , ( 1 ) 51 - 55 .
Wood PJ, Sansom JM, Stratford IJ, Adams GE, Szabo C, Thiemermann C, Vane JR ( 1994 ) . Modification of metabolism of transplantable and spontaneous murine tumors by the nitric oxide synthase inhibitor, nitro-L-arginine . International Journal of Radiation Oncology, Biology, Physics vol. 29 , ( 3 ) 443 - 447 .
Wu CC, Szabó C, Chen SJ, Thiemermann C, Vane JR ( 1994 ) . Activation of soluble guanylyl cyclase by a factor other than nitric oxide or carbon monoxide contributes to the vascular hyporeactivity to vasoconstrictor agents in the aorta of rats treated with endotoxin . Biochemical and Biophysical Research Communications vol. 201 , ( 1 ) 436 - 442 .
Szabó C, Thiemermann C, Wu CC, Perretti M, Vane JR ( 1994 ) . Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo . Proceedings of the National Academy of Sciences of the United States of America vol. 91 , ( 1 ) 271 - 275 .
Wellings RP, Corder R, Warner TD, Cristol J, Thiemermann C, Vane JR ( 1994 ) . Evidence from receptor antagonists of an important role for ET<inf>B</inf> receptor‐mediated vasoconstrictor effects of endothelin‐1 in the rat kidney . British Journal of Pharmacology vol. 111 , ( 2 ) 515 - 520 .
Szabó C, Southan GJ, Wood E, Thiemermann C, Vane JR ( 1994 ) . Inhibition by spermine of the induction of nitric oxide synthase in J774.2 macrophages: requirement of a serum factor . British Journal of Pharmacology vol. 112 , ( 2 ) 355 - 356 .
SzabÓ C, Thiemermann C ( 1994 ) . Invited opinion: Role of nitric oxide in hemorrhagic, traumatic, and anaphylactic shock and thermal injury . Shock vol. 2 , ( 2 ) 145 - 154 .
Akarasereenont P, Mitchell JA, Appleton I, Thiemermann C, Vane JR ( 1994 ) . Involvement of tyrosine kinase in the induction of cyclo‐oxygenase and nitric oxide synthase by endotoxin in cultured cells . British Journal of Pharmacology vol. 113 , ( 4 ) 1522 - 1528 .
Thiemermann C ( 1994 ) . The Role of the L-Arginine: Nitric Oxide Pathway in Circulatory Shock . Advances in Pharmacology , vol. 28 ,
McMurdo L, Thiemermann C, Vane JR ( 1994 ) . The effects of the endothelin ET<inf>A</inf> receptor antagonist, FR 139317, on infarct size in a rabbit model of acute myocardial ischaemia and reperfusion . British Journal of Pharmacology vol. 112 , ( 1 ) 75 - 80 .
Szabó C, Southan GJ, Thiemermann C, Vane JR ( 1994 ) . The mechanism of the inhibitory effect of polyamines on the induction of nitric oxide synthase: role of aldehyde metabolites . British Journal of Pharmacology vol. 113 , ( 3 ) 757 - 766 .
Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR ( 1993 ) . Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase . Proceedings of the National Academy of Sciences of the United States of America vol. 90 , ( 24 ) 11693 - 11697 .
Szabó C, Wu CC, Gross SS, Thiemermann C, Vane JR ( 1993 ) . Interleukin-1 contributes to the induction of nitric oxide synthase by endotoxin in vivo . European Journal of Pharmacology vol. 250 , ( 1 ) 157 - 160 .
Szabo C, Mitchell JA, Gross SS, Thiemermann C, Vane JR ( 1993 ) . Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide . Journal of Pharmacology and Experimental Therapeutics vol. 265 , ( 2 ) 674 - 680 .
Szabó C, Thiemermann C, Vane JR ( 1993 ) . Dihydropyridine Antagonists and Agonists of Calcium Channels Inhibit the Induction of Nitric Oxide Synthase by Endotoxin in Cultured Macrophages . Biochemical and Biophysical Research Communications vol. 196 , ( 2 ) 825 - 830 .
McMurdo L, Sessa WC, Thiemermann C, Vane JR ( 1993 ) . Ischaemia and reperfusion enhances the coronary vasoconstrictor effects of endothelin-1 in the rat isolated perfused heart . Pharmacology Communications vol. 3 , ( 2 ) 183 - 192 .
Wood PJ, Stratford IJ, Adams GE, Szabo C, Thiemermann C, Vane JR ( 1993 ) . Modification of energy metabolism and radiation response of a murine tumor by changes in nitric oxide availability . Biochemical and Biophysical Research Communications vol. 192 , ( 2 ) 505 - 510 .
Thiemermann C, Szabo C, Mitchell JA, Vane JR ( 1993 ) . Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide . Proceedings of the National Academy of Sciences of the United States of America vol. 90 , ( 1 ) 267 - 271 .
Thiemermann C ( 1993 ) . Drugs which modulate nitric oxide homeostasis are likely to provide therapeutic benefit in cardiovascular disease . Cardiovascular Research vol. 27 , ( 12 )
Thiemermann C, Mitchell JA, Ferns GAA ( 1993 ) . Eicosanoids and atherosclerosis . Current Opinion in Lipidology vol. 4 , ( 5 ) 401 - 406 .
McMurdo L, Lidbury PS, Corder R, Thiemermann C, Vane JR ( 1993 ) . Heterogeneous receptors mediate endothelin-1-induced changes in blood pressure, hematocrit, and platelet aggregation . Journal of Cardiovascular Pharmacology vol. 22 , ( SUPPL. 8 )
McMurdo L, Corder R, Thiemermann C, Vane JR ( 1993 ) . Incomplete inhibition of the pressor effects of endothelin‐1 and related peptides in the anaesthetized rat with BQ‐123 provides evidence for more than one vasoconstrictor receptor . British Journal of Pharmacology vol. 108 , ( 2 ) 557 - 561 .
Szabo C, Thiemermann C, Vane JR ( 1993 ) . Inhibition of the production of nitric oxide and vasodilator prostaglandins attenuates the cardiovascular response to bacterial endotoxin in adrenalectomized rats . Proceedings of the Royal Society B: Biological Sciences vol. 253 , ( 1338 ) 233 - 238 .
McMurdo L, Lidbury PS, Thiemermann C, Vane JR ( 1993 ) . Mediation of endothelin‐1‐induced inhibition of platelet aggregation via the ET<inf>B</inf> receptor . British Journal of Pharmacology vol. 109 , ( 2 ) 530 - 534 .
Cristol J, Warner TD, Thiemermann C, Vane JR ( 1993 ) . Mediation via different receptors of the vasoconstrictor effects of endothelins and sarafotoxins in the systemic circulation and renal vasculature of the anaesthetized rat . British Journal of Pharmacology vol. 108 , ( 3 ) 776 - 779 .
Szabó C, Mitchell JA, Thiemermann C, Vane JR ( 1993 ) . Nitric oxide‐mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock . British Journal of Pharmacology vol. 108 , ( 3 ) 786 - 792 .
Szabó C, Wu CC, Mitchell JA, Gross SS, Thiemermann C, Vane JR ( 1993 ) . Platelet-activating factor contributes to the induction of nitric oxide synthase by bacterial lipopolysaccharide . Circulation Research vol. 73 , ( 6 ) 991 - 999 .
Thiemermann C, Wu C, Szabó C, Perretti M, Vane JR ( 1993 ) . Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock . British Journal of Pharmacology vol. 110 , ( 1 ) 177 - 182 .
Cristol JP, Thiemermann C, Mitchell JA, Walder C, Vane JR ( 1993 ) . Support of renal blood flow after ischaemic‐reperfusion injury by endogenous formation of nitric oxide and of cyclo‐oxygenase vasodilator metabolites . British Journal of Pharmacology vol. 109 , ( 1 ) 188 - 194 .
Wellings RP, Warner TD, Thiemermann C, Cristol JP, Corder R, Vane JR ( 1993 ) . Vasoconstriction in the rat kidney induced by endothelin-1 is blocked by PD 145065 . Journal of Cardiovascular Pharmacology vol. 22 , ( SUPPL. 8 )
Thiemermann C, Corder R ( 1992 ) . Is endothelin-1 the regulator of myofibroblast contraction during wound healing? . Laboratory Investigation vol. 67 , ( 6 ) 677 - 679 .
Tettamanti R, Bianchi G, Vitte PA, Kato G, Porta R, Thiemermann C, Pescador R, Mantovani M ( 1992 ) . A novel insight into the mechanism of the antithrombotic action of defibrotide . Life Sciences vol. 51 , ( 19 ) 1545 - 1555 .
Huneidi AHS, Thiemermann C, Lidbury PS, Anggard EE, Vane JR, Afshar F ( 1992 ) . Do Endothelin-1 (ET-1) and human big-endothelin (b-ET) cause subarachnoid haemorrhage? . Journal of Neurology Neurosurgery and Psychiatry . vol. 55 ,
Sprague RS, Thiemermann C, Vane JR ( 1992 ) . Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli in anesthetized rabbits . Proceedings of the National Academy of Sciences of the United States of America vol. 89 , ( 18 ) 8711 - 8715 .
Walder CE, Thiemermann C, Vane JR ( 1992 ) . N<sup>G</sup>‐hydroxy‐L‐arginine prevents the haemodynamic effects of nitric oxide synthesis inhibition in the anaesthetized rat . British Journal of Pharmacology vol. 107 , ( 2 ) 476 - 480 .
Thiemermann C ( 1991 ) . Biosynthesis and interaction of endothelium-derived vasoactive mediators . Eicosanoids vol. 4 , ( 4 ) 187 - 202 .
Thiemermann C, Al-Damluji S, Hecker M, Vane JR ( 1991 ) . FMRF-amide and L-Arg-L-Phe increase blood pressure and heart rate in the anaesthetised rat by central stimulation of the sympathetic nervous system . Biochemical and Biophysical Research Communications vol. 175 , ( 1 ) 318 - 324 .
Huneidi AHS, Thiemermann C, Lidbury PS, D'Orléans-Juste P, Änggård EE, Afshar F, Vane JR ( 1991 ) . Endothelin-1 and big endothelin cause subarachnoid hemorrhage in the anesthetized rabbit . Journal of Cardiovascular Pharmacology vol. 17 , S492 - S495 .
Thiemermann C, Mustafa M, Mester PA, Mitchell JA, Hecker M, Vane JR ( 1991 ) . Inhibition of the release of endothelium‐derived relaxing factor in vitro and in vivo by dipeptides containing N<sup>G</sup>‐nitro‐l‐arginine . British Journal of Pharmacology vol. 104 , ( 1 ) 31 - 38 .
Walder CE, Thiemermann C, Vane JR ( 1991 ) . The involvement of endothelium‐derived relaxing factor in the regulation of renal cortical blood flow in the rat . British Journal of Pharmacology vol. 102 , ( 4 ) 967 - 973 .
Lidbury PS, Thiemermann C, Korbut R, Vane JR ( 1990 ) . Endothelins release tissue plasminogen activator and prostanoids . European Journal of Pharmacology vol. 186 , ( 2-3 ) 205 - 212 .
Thiemermann C, Vane J ( 1990 ) . Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo . European Journal of Pharmacology vol. 182 , ( 3 ) 591 - 595 .
Hecker M, Mitchell JA, Harris HJ, Katsura M, Thiemermann C, Vane JR ( 1990 ) . Endothelial cells metabolize N<sup>G</sup>-monomethyl-L-arginine to L-citrulline and subsequently to L-arginine . Biochemical and Biophysical Research Communications vol. 167 , ( 3 ) 1037 - 1043 .
Walder CE, Thiemermann C, Vane JR ( 1990 ) . EDRF-mediation of the pentagastrin-induced hyperaemia in the gastric mucosa of the anaesthetized rat in vivo . Journal of Physiology . vol. 425 ,
Thiemermann C, May GR, Page CP, Vane JR ( 1990 ) . Endothelin-1 inhibits platelet aggregation in vivo: a study with <sup>111</sup>indium-labelled platelets . British Journal of Pharmacology vol. 99 , ( 2 ) 303 - 308 .
Walder CE, Thiemermann C, Vane JR ( 1990 ) . Endothelium-derived relaxing factor participates in the increased blood flow in response to pentagastrin in the rat stomach mucosa . Proceedings of the Royal Society B: Biological Sciences vol. 241 , ( 1302 ) 195 - 200 .
Hecker M, Mitchell JA, Harris HJ, Katsura M, Thiemermann C, Vane JR ( 1990 ) . N(G)-monomethyl-L-arginine but not N(ω)-nitro-L-arginine is metabolized by endothelial cells to L-citrulline . European Journal of Pharmacology . vol. 183 , 648 - 649 .
Thomas GR, Walder CE, Thiemermann C, Vane JR ( 1990 ) . Regional vascular resistance and haemodynamics in the spontaneously hypertensive rat: The effects of bradykinin . Journal of Cardiovascular Pharmacology vol. 15 , ( 2 ) 211 - 217 .
Schror K, Thiemermann C ( 1989 ) . Eicosanoids in myocardial ischemia . Biomedica Biochimica Acta . vol. 48 , 729 - 734 .
Lidbury PS, Thiemermann C, Roger Thomas G, Vane JR ( 1989 ) . Endothelin-3: selectivity as an anti-aggregatory peptide in vivo . European Journal of Pharmacology vol. 166 , ( 2 ) 335 - 338 .
Thiemermann C, Thomas GR, Vane JR ( 1989 ) . Defibrotide reduces infarct size in a rabbit model of experimental myocardial ischaemia and reperfusion . British Journal of Pharmacology vol. 97 , ( 2 ) 401 - 408 .
Thiemermann C, Thomas GR, Vane JR ( 1989 ) . Effects of defibrotide on infarct size and regional myocardial blood flow on the ischaemic reperfused rabbit heart . Progress in clinical and biological research vol. 301 , 131 - 135 .
Thiemermann C, Lidbury PS, Roger Thomas G, Vane JR ( 1989 ) . Endothelin-1 releases prostacyclin and inhibits ex vivo platelet aggregation in the anesthetized rabbit . Journal of Cardiovascular Pharmacology vol. 13 , S138 - S141 .
Hohlfeld T, Thiemermann C, Schrör K ( 1989 ) . Protection from myocardial ischemic injury in cats and pigs by defibrotide--different mode of action? . Progress in clinical and biological research vol. 301 , 137 - 141 .
Walder CE, Roger Thomas G, Thiemermann C, Vane JR ( 1989 ) . The hemodynamic effects of endothelin-1 in the pithed rat . Journal of Cardiovascular Pharmacology vol. 13 , S93 - S97 .
Thiemermann C, Lidbury P, Thomas R, Vane J ( 1988 ) . Endothelin inhibits ex vivo platelet aggregation in the rabbit . European Journal of Pharmacology vol. 158 , ( 1-2 ) 181 - 182 .
Thiemermann C, Ney P, Schror K ( 1988 ) . Protection of the ischaemic myocardium from reperfusion injury by defibrotide and its possible mechanism of action . Biomedica Biochimica Acta vol. 47 , ( 10-11 )
Thiemermann C, Ney P, Schrör K ( 1988 ) . The thromboxane receptor antagonist, daltroban, protects the myocardium from ischaemic injury resulting in suppression of leukocytosis . European Journal of Pharmacology vol. 155 , ( 1-2 ) 57 - 67 .
Schrör K, Thiemermann C, Ney P ( 1988 ) . Protection of the ischemic myocardium from reperfusion injury by prostaglandin E<inf>1</inf> inhibition of ischemia-induced neutrophil activation . Naunyn-Schmiedeberg's Archives of Pharmacology vol. 338 , ( 3 ) 268 - 274 .
Thomas GR, Thiemermann C, Walder C, Vane JR ( 1988 ) . The effects of endothelium‐dependent vasodilators on cardiac output and their distribution in the anaesthetized rat: a comparison with sodium nitroprusside . British Journal of Pharmacology vol. 95 , ( 3 ) 986 - 992 .
Thiemermann C, Smith EF, Schrör K ( 1986 ) . Successful treatment of acute myocardial ischaemia with teopranitol-a novel organic nitrate . European Heart Journal vol. 7 , ( 5 ) 418 - 424 .
Schrör K, Thiemermann C ( 1986 ) . Treatment of acute myocardial ischaemia with a selective antagonist of thromboxane receptors (BM 13.177) . British Journal of Pharmacology vol. 87 , ( 4 ) 631 - 637 .
Thiemermann C, Löbel P, Schrör K ( 1985 ) . Usefulness of defibrotide in protecting ischemic myocardium from early reperfusion damage . The American Journal of Cardiology vol. 56 , ( 15 ) 978 - 982 .
Thiemermann C, Schror K ( 1984 ) . Comparison of the thromboxane synthetase inhibitor dazoxiben and the prostacyclin mimetic iloprost in an animal model of acute ischaemia and reperfusion . Biomedica Biochimica Acta vol. 43 , ( 8-9 )
Thiemermann C, Steinhagen-Thiessen E, Schrör K ( 1984 ) . Inhibition of oxygen-centered free radical formation by the stable prostacyclin-mimetic iloprost (ZK 36 374) in acute myocardial ischemia . Journal of Cardiovascular Pharmacology vol. 6 , ( 2 ) 365 - 366 .