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Research

Publications: Dr Mathieu-Benoit Voisin

Joulia R, Guerrero-Fonseca IM, Girbl T, Coates JA, Stein M, Vázquez-Martínez L, Lynam E, Whiteford J et al. ( 2022 ) . Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A . Nat Commun vol. 13 , ( 1 )
Iqbal AJ, Krautter F, Blacksell IA, Wright RD, Austin-Williams SN, Voisin MB, Hussain MT, Law HL et al. ( 2022 ) . Galectin-9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin-dependent manner . FASEB Journal vol. 36 , ( 1 )
Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS et al. ( 2021 ) . Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation . Immunity vol. 54 , ( 9 ) 1989 - 2004.e9 .
Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M et al. ( 2021 ) . Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage . Immunity vol. 54 , ( 7 ) 1494 - 1510.e7 .
Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C et al. ( 2020 ) . Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody . Frontiers in Immunology vol. 11 ,
Owen-Woods C, Joulia R, Barkaway A, Rolas L, Ma B, Nottebaum FA, Arkill KP, Stein M et al. ( 2020 ) . Local microvascular leakage promotes trafficking of activated neutrophils to remote organs . Journal of Clinical Investigation
Arokiasamy S, King R, Boulaghrasse H, Poston R, Nourshargh S, Wang W, Voisin M-B ( 2019 ) . Heparanase-dependent Remodelling of Initial Lymphatic Glycocalyx 1 Regulates Tissue-fluid Drainage during Acute Inflammation in vivo . Frontiers in Immunology
Voisin MB, Nourshargh S ( 2019 ) . Neutrophil trafficking to lymphoid tissues: physiological and pathological implications . Journal of Pathology vol. 247 , ( 5 ) 662 - 671 .
VOISIN M, leoni G, WOODFIN A, loumagne L, PATEL N, Di Paola R, Cuzzocrea S, THIEMERMANN C et al. ( 2019 ) . Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury . Journal of Pathology vol. 248 , ( 1 ) 88 - 102 .
GIRBL T, Lenn T, Perez L, ROLAS L, BARKAWAY A, Thiriot A, del Fresno C, Lynam E et al. ( 2018 ) . Distinct compartmentalization of the chemokines CXCL1 and CXCL2 and the atypical receptor ACKR1 determine discrete stages of neutrophil diapedesis . Immunity
Macdougall CE, Wood EG, Loschko J, Scagliotti V, Cassidy FC, Robinson ME, Feldhahn N, Castellano L et al. ( 2018 ) . Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets . Cell Metabolism vol. 27 , ( 3 ) 588 - 601.e4 .
Arokiasamy S, Nourshargh S, Wang W, Voisin M-B ( 2017 ) . Characterisation of the lymphatic endothelium glycocalyx and its regulation during acute inflammation in vivo . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . Conference: NA vol. 98 , A13 - A14 .
Barkaway A, Rolas L, Morrell S, Bodkin J, Golding M, Voisin M-B, Nourshargh S ( 2017 ) . Aged Vasculature Supports Enhanced and Aberrant Neutrophil-Vessel Wall Interactions in vivo . JOURNAL OF VASCULAR RESEARCH . Conference: 2nd Joint Meeting of the European-Society-for-Microcirculation (ESM) and European-Vascular-Biology-Organisation (EVBO) vol. 54 , 26 - 26 .
King R, Morrell S, Nedospasov S, Voisin M-B, Nourshargh S ( 2017 ) . An Investigation Into the Role of Neutrophil-Derived TNF in Pathophysiological Microvascular Hyperpermeability . JOURNAL OF VASCULAR RESEARCH . Conference: 2nd Joint Meeting of the European-Society-for-Microcirculation (ESM) and European-Vascular-Biology-Organisation (EVBO) vol. 54 , 64 - 64 .
Voisin MB ( 2017 ) . TNF-alpha drives the migration and crawling of neutrophils into afferent lymphatic vessels during antigen challenge in vivo . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . Conference: 51st Annual Scientific Meeting of the European Society for Clinical Investigation vol. 47 , 54 - 54 .
VOISIN M ( 2017 ) . Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation . Scientific Reports
Herrera C, Voisin M-B, Escalante T, Rucavado A, Nourshargh S, Gutiérrez JM ( 2016 ) . Effects of PI and PIII Snake Venom Haemorrhagic Metalloproteinases on the Microvasculature: A Confocal Microscopy Study on the Mouse Cremaster Muscle . PLoS One vol. 11 , ( 12 ) Article 0168643 , e0168643 - e0168643 .
Pickworth CM, Beal R, Reglero N, Lintermans L, Colom B, Voisin M-B, Golding M, Nourshargh S ( 2016 ) . Microvascular endothelial cells can exhibit autophagy in vivo: Role in neutrophil transendothelial cell migration? . FASEB JOURNAL . Conference: Experimental Biology Meeting vol. 30 ,
Woodfin A, Beyrau M, Voisin MB, Ma B, Whiteford JR, Hordijk PL, Hogg N, Nourshargh S ( 2016 ) . ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia . Blood vol. 127 , ( 7 ) 898 - 907 .
Schnoor M, Alcaide P, Voisin MB, Van Buul JD ( 2016 ) . Recruitment of Immune Cells into Inflamed Tissues: Consequences for Endothelial Barrier Integrity and Tissue Functionality . Mediators of Inflammation vol. 2016 ,
Herrera C, Escalante T, Voisin MB, Rucavado A, Morazán D, Macêdo JKA, Calvete JJ, Sanz L et al. ( 2015 ) . Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage . PLoS Neglected Tropical Diseases vol. 9 , ( 4 )
Schnoor M, Alcaide P, Voisin MB, Van Buul JD ( 2015 ) . Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation . Mediators of Inflammation vol. 2015 ,
Finsterbusch M, Voisin M-B, Beyrau M, Williams TJ, Nourshargh S ( 2014 ) . Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF . J Exp Med vol. 211 , ( 7 ) 1307 - 1314 .
Colom B, Bodkin J, Voisin MB, Leinster DA, Aurrand-Lions M, Chavakis T, Imhof BA, Nourshargh S ( 2013 ) . Junctional adhesion molecule (JAM)-C can be cleaved by neutrophil elastase at sites of inflammation in vivo . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION vol. 43 , 16 - 16 .
Voisin M-B, Nourshargh S ( 2013 ) . Neutrophil transmigration: emergence of an adhesive cascade within venular walls . J Innate Immun vol. 5 , ( 4 ) 336 - 347 .
Proebstl D, Voisin M-B, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D, Nourshargh S ( 2012 ) . Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo . J Exp Med vol. 209 , ( 6 ) 1219 - 1234 .
Woodfin A, Voisin M-B, Beyrau M, Colom B, Caille D, Diapouli F-M, Nash GB, Chavakis T et al. ( 2011 ) . The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo . Nat Immunol vol. 12 , ( 8 ) 761 - 769 .
Leoni G, Voisin M-B, Carlson K, Getting S, Nourshargh S, Perretti M ( 2010 ) . The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature . Br J Pharmacol vol. 160 , ( 1 ) 171 - 180 .
Woodfin A, Voisin M-B, Colom B, Nourshargh S ( 2010 ) . An investigation into the profile and dynamics of neutrophil transendothelial cell migration (TEM) using high resolution in vivo real-time confocal imaging . FASEB JOURNAL vol. 24 ,
Woodfin A, Voisin M-B, Nourshargh S ( 2010 ) . Recent developments and complexities in neutrophil transmigration . Curr Opin Hematol vol. 17 , ( 1 ) 9 - 17 .
Voisin M-B, Pröbstl D, Nourshargh S ( 2010 ) . Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation . Am J Pathol vol. 176 , ( 1 ) 482 - 495 .
Scheiermann C, Colom B, Meda P, Patel NSA, Voisin M-B, Marrelli A, Woodfin A, Pitzalis C et al. ( 2009 ) . Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury . Arterioscler Thromb Vasc Biol vol. 29 , ( 10 ) 1509 - 1515 .
Voisin M-B, Woodfin A, Nourshargh S ( 2009 ) . Monocytes and neutrophils exhibit both distinct and common mechanisms in penetrating the vascular basement membrane in vivo . Arterioscler Thromb Vasc Biol vol. 29 , ( 8 ) 1193 - 1199 .
Woodfin A, Voisin MB, Imhof BA, Dejana E, Engelhardt B, Nourshargh S ( 2009 ) . Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1 . BLOOD vol. 113 , ( 24 ) 6246 - 6257 .
Woodfin A, Voisin M-B, Imhof BA, Dejana E, Engelhardt B, Nourshargh S ( 2009 ) . Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1 . Blood vol. 113 , ( 24 ) 6246 - 6257 .
Proebstl D, Voisin M-B, Nourshargh S ( 2009 ) . Pericytes facilitate leukocyte transmigration in vivo . FASEB JOURNAL vol. 23 ,
Woodfin A, Voisin M-B, Nourshargh S ( 2007 ) . PECAM-1: a multi-functional molecule in inflammation and vascular biology . Arterioscler Thromb Vasc Biol vol. 27 , ( 12 ) 2514 - 2523 .
Woodfin A, Reichel CA, Khandoga A, Corada M, Voisin M-B, Scheiermann C, Haskard DO, Dejana E et al. ( 2007 ) . JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration . Blood vol. 110 , ( 6 ) 1848 - 1856 .
Young RE, Voisin M-B, Wang S, Dangerfield J, Nourshargh S ( 2007 ) . Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice . Br J Pharmacol vol. 151 , ( 5 ) 628 - 637 .
Voisin MB, Woodfin A, Nourshargh S ( 2007 ) . Neutrophil and monocyte transmigration elicited by ischemia/reperfusion (I/R) injury and CCL2 is associated with remodelling of the venular basement membrane (BM) in vivo . FASEB JOURNAL . vol. 21 , A127 - A127 .
Wang S, Voisin M-B, Larbi KY, Dangerfield J, Scheiermann C, Tran M, Maxwell PH, Sorokin L et al. ( 2006 ) . Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils . J Exp Med vol. 203 , ( 6 ) 1519 - 1532 .
Voisin MB, Woodfin A, Dawes T, Nourshargh S ( 2006 ) . Neutrophil elastase (NE) deficient mice exhibit reduced leukocyte transmigration in response to ischaemia/reperfusion (I/R) injury . FASEB JOURNAL . vol. 20 , A1083 - A1083 .
Voisin MB, Wang SJ, Larbi K, Scheiermann C, Sorokin L, Nourshargh S ( 2006 ) . Neutrophils play a direct role in enhancing the size of venular basement membrane (BM) matrix protein low expression regions . FASEB JOURNAL . vol. 20 , A1322 - A1322 .
Voisin MB, Young R, Dangerfield J, Wijayasiri L, Wang SJ, Nourshargh S ( 2005 ) . LTB4 is a potent inducer of cell surface neutrophil elastase (NE), a response that appears to play a role in LTB4-induced neutrophil transmigration in vivo . FASEB JOURNAL . vol. 19 , A1717 - A1717 .
Wang SJ, Dangerfield J, Voisin MB, Tran M, Maxwell P, Sorokin L, Nourshargh S ( 2005 ) . Pre-formed matrix protein "low expression" regions act as exit points for leukocytes migrating through the venular perivascular basement membrane . FASEB JOURNAL . vol. 19 , A1504 - A1504 .
Voisin M-B, Buzoni-Gatel D, Bout D, Velge-Roussel F ( 2004 ) . Both expansion of regulatory GR1+ CD11b+ myeloid cells and anergy of T lymphocytes participate in hyporesponsiveness of the lung-associated immune system during acute toxoplasmosis . Infect Immun vol. 72 , ( 9 ) 5487 - 5492 .
Voisin M-B, Bitard J, Daburon S, Moreau J-F, Taupin J-L ( 2002 ) . Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation . J Biol Chem vol. 277 , ( 16 ) 13682 - 13692 .