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Research

Publications: Prof Denise Sheer

Boot J, Rosser G, Kancheva D, Vinel C, Lim YM, Pomella N, Zhang X, Guglielmi L et al. ( 2022 ) . Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape . eLife vol. 11 ,
Woodward L, Jones TA, Patel A, Dokal AD, Stone TJ, Rajeeve V, Cutillas PR, Jones DTW et al. ( 2022 ) . LGG-44. Multi-omic analysis reveals integrated signalling networks in paediatric low-grade glioma . Neuro-Oncology vol. 24 , ( Suppl 1 ) i98 - i98 .
Woodward L, Jones TA, Patel A, Dokal AD, Stone TJ, Rajeeve V, Cutillas PR, Jones DTW et al. ( 2022 ) . MULTI-OMIC ANALYSIS REVEALS INTEGRATED SIGNALLING NETWORKS IN PAEDIATRIC LOW-GRADE GLIOMA . NEURO-ONCOLOGY . vol. 24 , 98 - 98 .
Marino S ( 2021 ) . Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC‐derived neural stem cells in glioblastoma . Nature Communications
Adiutori R, Puentes F, Bremang M, Lombardi V, Zubiri I, Leoni E, Aarum J, Sheer D et al. ( 2021 ) . Analysis of circulating protein aggregates as a route of investigation into neurodegenerative disorders . Brain Communications vol. 3 , ( 3 )
Patel A, Jones T, Woodward L, Dokal A, Rajeeve V, Cutillas P, Stone T, Jacques T et al. ( 2020 ) . LGG-57. SIGNALLING MECHANISMS IN PAEDIATRIC LOW-GRADE GLIOMA . Neuro-Oncology vol. 22 , ( Suppl 3 ) iii377 - iii377 .
Patel A, Jones T, Woodward L, Dokal A, Rajeeve V, Cutillas P, Stone T, Jacques T et al. ( 2020 ) . LGG-57. SIGNALLING MECHANISMS IN PAEDIATRIC LOW-GRADE GLIOMA . Neuro-oncology vol. 22 , ( Suppl 3 ) iii377 - iii377 .
Patel A, Jones T, Woodward L, Dokal A, Rajeeve V, Cutillas P, Stone T, Jacques T et al. ( 2020 ) . SIGNALLING MECHANISMS IN PAEDIATRIC LOW-GRADE GLIOMA . NEURO-ONCOLOGY . vol. 22 , 377 - 377 .
Aarum J, Cabrera CP, Jones TA, Rajendran S, Adiutori R, Giovannoni G, Barnes MR, Malaspina A et al. ( 2020 ) . Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates . EMBO Reports vol. 21 , ( 10 )
Aarum J, Cabrera CP, Jones TA, Rajendran S, Adiutori R, Giovannoni G, Barnes MR, Malaspina A et al. ( 2020 ) . Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates . EMBO Reports vol. 21 , ( 10 ) Article ARTN e49585 ,
Dumas A, Pomella N, Rosser G, Guglielmi L, Vinel C, Millner T, Rees J, Aley N et al. ( 2020 ) . Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment . The EMBO Journal
Adiutori R, Puentes F, Bremang M, Lombardi V, Zubiri I, Leoni E, Aarum J, Sheer D et al. ( 2020 ) . Analysis of circulating protein aggregates reveals pathological hallmarks of amyotrophic lateral sclerosis .
Merve A, Zhang X, Pomella N, Acquati S, Hoeck JD, Dumas A, Rosser G, Li Y et al. ( 2019 ) . Correction to: C-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism (Acta Neuropathologica Communications (2019) 7:95 DOI: 10.1186/s40478-019-0739-x) . Acta Neuropathologica Communications vol. 7 , ( 1 )
Merve A, Zhang X, Pomella N, Acquati S, Hoeck J, Dumas A, Rosser G, Li Y et al. ( 2019 ) . Choroid plexus papillomas are induced by c-Myc overexpression in the choroid plexus via a T-cell inflammatory mechanism . Neuro-Oncology . vol. 21 , iv9 - iv10 .
Merve A, Zhang X, Pomella N, Acquati S, Hoeck J, Dumas A, Rosser G, Li Y et al. ( 2019 ) . Choroid plexus papillomas are induced by c-Myc overexpression in the choroid plexus via a T-cell inflammatory mechanism . Neuro-oncology vol. 21 , ( Suppl 4 ) iv9 - iv10 .
Caley M, Marsh S, Martins VL, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al. ( 2019 ) . 298 Defective DNA Repair and Chromosomal Instability in RDEB . Journal of Investigative Dermatology . vol. 139 ,
Marsh S, Caley MP, Martins VLC, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al. ( 2019 ) . Type VII collagen and Nesprin 2: LINCing the basement membrane to altered cell cycle and increased DNA damage . BRITISH JOURNAL OF DERMATOLOGY . vol. 180 , E188 - E189 .
Merve A, Zhang X, Pomella N, Acquati S, Hoeck JD, Dumas A, Rosser G, Li Y et al. ( 2019 ) . C-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism . Acta Neuropathologica Communications vol. 7 , ( 1 )
Adiutori R, Aarum J, Zubiri I, Bremang M, Jung S, Sheer D, Pike I, Malaspina A ( 2018 ) . The proteome of neurofilament-containing protein aggregates in blood . Biochemistry and Biophysics Reports vol. 14 , 168 - 177 .
Jeyapalan JN, Doctor GT, Jones TA, Alberman SN, Tep A, Haria CM, Schwalbe EC, Morley ICF et al. ( 2016 ) . DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas . Acta Neuropathologica Communications vol. 4 , ( 1 )
Noor DAM, Jeyapalan JN, Alhazmi S, Carr M, Squibb B, Wallace C, Tan C, Cusack M et al. ( 2016 ) . Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines . npj Genomic Medicine vol. 1 ,
Jones TA, Jeyapalan JN, Forshew T, Tatevossian RG, Lawson ARJ, Patel SN, Doctor GT, Mumin MA et al. ( 2015 ) . Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-κB pathways . Acta neuropathologica communications vol. 3 ,
Jeyapalan JN, Haria CM, Jones TA, Tatevossian RG, Qaddoumi I, Ellison DW, Sheer D ( 2015 ) . PO77EXPRESSION OF THE ONCOGENIC SPLICE VARIANT OF CYCLIN D1, CCND1B, IN PAEDIATRIC LOW GRADE GLIOMAS . Neuro-Oncology vol. 17 , ( suppl_8 ) viii14 - viii14 .
Sheer D, Jeyapalan J, Doctor GT, Jones TA, Alberman SN, Tep A, Haria CM, Schwalbe EC et al. ( 2015 ) . DNA METHYLATION ANALYSIS OF PAEDIATRIC LOW-GRADE ASTROCYTOMAS IDENTIFIES A TUMOUR-SPECIFIC SIGNATURE AT A SET OF ENHANCERS . PEDIATRIC BLOOD & CANCER vol. 62 , S283 - S284 .
Jeyapalan JN, Haria CM, Jones TA, Tatevossian RG, Qaddoumi I, Ellison DW, Sheer D ( 2015 ) . EXPRESSION OF THE ONCOGENIC SPLICE VARIANT OF CYCLIN D1, CCND1B, IN PAEDIATRIC LOW GRADE GLIOMAS . NEURO-ONCOLOGY . vol. 17 , 14 - 14 .
Coll-Bastus N, Mao X, Young BD, Sheer D, Lu Y-J ( 2015 ) . DNA replication-dependent induction of gene proximity by androgen . Hum Mol Genet vol. 24 , ( 4 ) 963 - 971 .
Jeyapalan JN, Jones TA, Tatevossian RG, Qaddoumi I, Ellison D, Sheer D ( 2014 ) . MICRORNA PROFILING USING SMALL RNA-SEQ IN PAEDIATRIC LOW GRADE GLIOMAS . NEURO-ONCOLOGY . vol. 16 ,
Jeyapalan JN, Jones TA, Tatevossian RG, Qaddoumi I, Ellison DW, Sheer D ( 2014 ) . OP17MICRORNA PROFILING USING SMALL RNA-SEQ IN PAEDIATRIC LOW GRADE GLIOMAS . Neuro-Oncology vol. 16 , ( suppl_6 ) vi19 - vi19 .
Ottaviani D, LeCain M, Sheer D ( 2014 ) . The role of microhomology in genomic structural variation . Trends Genet vol. 30 , ( 3 ) 85 - 94 .
Bastus NC, Mao X, Young BD, Sheer D, Lu Y-J ( 2014 ) . Novel function of androgen receptor-the regulation of DNA replication and genomic movement . INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE vol. 34 , S89 - S89 .
Ogunkolade BW, Jones TA, Aarum J, Szary J, Owen N, Ottaviani D, Mumin MA, Patel S et al. ( 2013 ) . BORIS/CTCFL is an RNA-binding protein that associates with polysomes . BMC Cell Biol vol. 14 ,
Henriquez NV, Forshew T, Tatevossian R, Ellis M, Richard-Loendt A, Rogers H, Jacques TS, Reitboeck PG et al. ( 2013 ) . Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumor propagation in vitro . Cancer Res vol. 73 , ( 18 ) 5834 - 5844 .
Zhang J, Wu G, Miller CP, Tatevossian RG, Dalton JD, Tang B, Orisme W, Punchihewa C et al. ( 2013 ) . Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas . Nature Genetics vol. 45 , ( 6 ) 602 - 612 .
Forshew T, Lewis P, Waldman A, Peterson D, Glaser M, Brock C, Sheer D, Mulholland PJ ( 2013 ) . Three different brain tumours evolving from a common origin . Oncogenesis vol. 2 , ( 4 )
Jeyapalan JN, Patel SN, Forshew T, Lawson ARJ, Tatevossian RG, Corbett-Jones T, Mumin MA, Picker SR et al. ( 2012 ) . MICRORNA SIGNATURES IN A BROAD COHORT OF PAEDIATRIC BRAIN TUMOURS . PEDIATRIC BLOOD & CANCER vol. 59 , ( 6 ) 1084 - 1084 .
Jeyapalan JN, Morley ICF, Hill AA, Mumin MA, Tatevossian RG, Qaddoumi I, Ellison DW, Sheer D ( 2012 ) . DNA METHYLATION PROFILING OF LOW GRADE ASTROCYTOMAS USING THE ILLUMINA 450K BEADCHIP REVEALS CHANGES IN GENES INVOLVED IN BRAIN DEVELOPMENT AND DRUG RESISTANCE . NEURO-ONCOLOGY . vol. 14 , 3 - 3 .
Ottaviani D, Lever E, Mao S, Christova R, Ogunkolade BW, Jones TA, Szary J, Aarum J et al. ( 2012 ) . CTCF binds to sites in the major histocompatibility complex that are rapidly reconfigured in response to interferon-gamma . Nucleic Acids Res vol. 40 , ( 12 ) 5262 - 5270 .
Jeyapalan JN, Morley ICF, Hill AA, Tatevossian RG, Qaddoumi I, Ellison D, Sheer D ( 2012 ) . DNA METHYLATION PROFILING OF LOW GRADE ASTROCYTOMAS USING THE ILLUMINA 450K BEADCHIP REVEALS CHANGES IN GENES INVOLVED IN BRAIN DEVELOPMENT AND DRUG RESISTANCE . NEURO-ONCOLOGY . vol. 14 , 77 - 77 .
Viana-Pereira M, Pereira M, Burford A, Jury A, Popov S, Perryman L, Bax D, Forshew T et al. ( 2012 ) . MOLECULAR DETERMINANTS OF EFFICACY OF MET RECEPTOR INHIBITION IN PAEDIATRIC GLIOBLASTOMA . NEURO-ONCOLOGY . vol. 14 , 66 - 67 .
Tatevossian R, Qaddoumi I, Tang B, Dalton J, Shurtleff S, Punchihewa C, Orisme W, Neale G et al. ( 2012 ) . RAF GENE ABNORMALITIES DEFINE SUBSETS OF PEDIATRIC LOW-GRADE GLIOMAS AND GLIONEURONAL TUMORS . NEURO-ONCOLOGY . vol. 14 , 77 - 78 .
Ellison D, Tatevossian R, Qaddoumi I, Tang B, Dalton J, Shurtleff S, Punchihewa C, Orisme W et al. ( 2012 ) . RAF Gene Abnormalities Define Subsets of Pediatric Low-Grade Gliomas and Glioneuronal Tumors . JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY . vol. 71 , 577 - 577 .
Nicolaides T, Hariono S, Barkovich K, Hashizume R, Rowitch D, Weiss W, Sheer D, Baker S et al. ( 2011 ) . TARGETED THERAPY FOR BRAFV600E MUTANT MALIGNANT ASTROCYTOMA . NEURO-ONCOLOGY vol. 13 , 112 - 112 .
Bezecny P, Sang NJPXWF, Mumin MA, Pieri C, Mulholland PJ, Sheer D ( 2011 ) . Addition of Erlotinib Changes Gene Expression in Glioblastoma Cell Lines Treated With Vorinostat . EUROPEAN JOURNAL OF CANCER . vol. 47 , S578 - S578 .
Hashizume R, Aoki Y, Hariono S, Huillard E, Rowitch D, Jones C, Forshew T, Sheer D et al. ( 2011 ) . COMBINATION-TARGETED THERAPY SHOWS IMPROVED EFFICACY AGAINST BRAF(V600E) MUTANT MALIGNANT ASTROCYTOMAS . NEURO-ONCOLOGY . vol. 13 , I1 - I1 .
Tatevossian R, Tang B, Dalton J, Forshew T, Lawson A, Ma J, Neale G, Shurtleff S et al. ( 2011 ) . MYB UPREGULATION AND GENETIC ABERRATIONS IN A SUBSET OF PEDIATRIC LOW-GRADE GLIOMAS . NEURO-ONCOLOGY . vol. 13 , I5 - I5 .
Lawson ARJ, Hindley GFL, Forshew T, Tatevossian RG, Jamie GA, Kelly GP, Neale GA, Ma J et al. ( 2011 ) . RAF GENE FUSION BREAKPOINTS IN PEDIATRIC BRAIN TUMORS ARE CHARACTERIZED BY SIGNIFICANT ENRICHMENT OF SEQUENCE MICROHOMOLOGY . NEURO-ONCOLOGY . vol. 13 , I24 - I25 .
Lawson ARJ, Hindley GFL, Forshew T, Tatevossian RG, Jamie GA, Kelly GP, Neale GA, Ma J et al. ( 2011 ) . RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology . Genome Res vol. 21 , ( 4 ) 505 - 514 .
Jeyapalan JN, Mumin MA, Forshew T, Lawson ARJ, Tatevossian RG, Jacques TS, Sheer D ( 2011 ) . MICRORNA EXPRESSION IN PAEDIATRIC BRAIN TUMOURS . NEURO-ONCOLOGY . vol. 13 , 6 - 6 .
Jones TA, Ogunkolade BW, Szary J, Aarum J, Mumin MA, Patel S, Pieri CA, Sheer D ( 2011 ) . Widespread expression of BORIS/CTCFL in normal and cancer cells . PLoS One vol. 6 , ( 7 )
Tatevossian RG, Tang B, Dalton J, Forshew T, Lawson AR, Ma J, Neale G, Shurtleff SA et al. ( 2010 ) . MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas . ACTA NEUROPATHOL vol. 120 , ( 6 ) 731 - 743 .
Tatevossian R, Tang B, Forshew T, Lawson A, Dalton J, Ma J, Neale G, Broniscer A et al. ( 2010 ) . DNA COPY NUMBER CHANGES AND KIAA1549-BRAF FUSION GENE DETECTION IN 125 PEDIATRIC LOW-GRADE GLIOMAS . PEDIATR BLOOD CANCER vol. 55 , ( 5 ) 798 - 799 .
Bezecny P, Pieri C, Szary J, Mulholland PJ, Sheer D ( 2010 ) . HISTONE DEACETYLASE INHIBITOR VORINOSTAT REDUCES EXPRESSION OF PLATELET-DERIVED GROWTH FACTOR RECEPTOR A (PDGFRA) AND MATRIX METALLOPROTEINASE-2 (MMP2) GENES IN GLIOBLASTOMA CELL LINES . ANNALS OF ONCOLOGY . vol. 21 , 333 - 334 .
Lawson ARJ, Tatevossian RG, Phipps KP, Picker SR, Michalski A, Sheer D, Jacques TS, Forshew T ( 2010 ) . RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort . Acta Neuropathol vol. 120 , ( 2 ) 271 - 273 .
Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S et al. ( 2010 ) . Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome (Corrigendum) . NATURE vol. 466 , ( 7304 )
Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S et al. ( 2010 ) . Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome . Nature vol. 465 , ( 7299 ) 813 - 817 .
Forshew T, Lawson ARJ, Hindley GFL, Tatevossian RG, Jamie G, Ellison DW, Sheer D ( 2010 ) . BREAKPOINT ANALYSIS OF RAF GENE FUSIONS IN PAEDIATRIC LOW-GRADE ASTROCYTOMAS . NEURO-ONCOLOGY . vol. 12 , II23 - II23 .
Tatevossian RG, Lawson ARJ, Forshew T, Hindley GFL, Ellison DW, Sheer D ( 2010 ) . MAPK pathway activation and the origins of pediatric low-grade astrocytomas . J Cell Physiol vol. 222 , ( 3 ) 509 - 514 .
Lever E, Sheer D ( 2010 ) . The role of nuclear organization in cancer . J Pathol vol. 220 , ( 2 ) 114 - 125 .
Ellison D, Forshew T, Tatevossian R, Lawson A, Ma J, Neale G, Dalton J, Broniscer A et al. ( 2009 ) . ABNORMALITIES OF THE MAPK PATHWAY IN PEDIATRIC LOW-GRADE GLIOMAS . NEURO-ONCOLOGY . vol. 11 , 610 - 610 .
Forshew T, Tatevossian RG, Lawson ARJ, Ma J, Neale G, Ogunkolade BW, Jones TA, Aarum J et al. ( 2009 ) . Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas . J Pathol vol. 218 , ( 2 ) 172 - 181 .
Ellison D, Forshew T, Tatevossian R, Ma J, Neale G, Ogunkolade W, Dalton J, Bailey S et al. ( 2009 ) . Activation of the MAPK Pathway: A Signature Genetic Defect in Posterior Fossa Pilocytic Astrocytomas . JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY vol. 68 , ( 5 ) 566 - 567 .
Dorine B, Little L, Gaspar N, Perryman L, Marshall L, Viana-Pereira M, Jones T, Williams RD et al. ( 2009 ) . Molecular and Phenotypic Characterisation of Paediatric Glioma Cell Lines as Models for Preclinical Drug Development . PLoS.ONE vol. 4 , ( 4 )
Bax DA, Little SE, Gaspar N, Perryman L, Marshall L, Viana-Pereira M, Jones TA, Williams RD et al. ( 2009 ) . Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development . PLoS One vol. 4 , ( 4 )
Ottaviani D, Lever E, Mitter R, Jones T, Forshew T, Christova R, Tomazou EM, Rakyan VK et al. ( 2008 ) . Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex . Genome Res vol. 18 , ( 11 ) 1778 - 1786 .
Tatevossian R, Forshew T, Bax D, Mitter R, Jones C, Sheer D ( 2008 ) . IDENTIFICATION OF CANDIDATE TUMOR SUPPRESSOR GENES IN PEDIATRIC ASTROCYTOMA USING NONSENSE-MEDIATED DECAY INHIBITION AND DEVELOPMENT OF A NOVEL GENE INTERACTION NETWORK . NEURO-ONCOLOGY . vol. 10 , 803 - 803 .
Forshew T, Tatevossian R, Clifford S, Ellison D, Sheer D ( 2008 ) . MOLECULAR GENETIC AND EPIGENETIC ANALYSIS OF PEDIATRIC LOW-GRADE ASTROCYTIC GLIOMAS . NEURO-ONCOLOGY . vol. 10 , 800 - 800 .
Tomazou EM, Rakyan VK, Lefebvre G, Andrews R, Ellis P, Jackson DK, Langford C, Francis MD et al. ( 2008 ) . Generation of a genomic tiling array of the human Major Histocompatibility Complex (MHC) and its application for DNA methylation analysis . BMC Med Genomics vol. 1 , ( 1 )
Ottaviani D, Lever E, Takousis P, Sheer D ( 2008 ) . Anchoring the genome . Genome Biol vol. 9 , ( 1 )
Takousis P, Johonnett P, Williamson J, Sasieni P, Warnes G, Forshew T, Azuara V, Fisher A et al. ( 2007 ) . Replication timing profile reflects the distinct functional and genomic features of the MHC class II region . CELL CYCLE vol. 6 , ( 19 ) 2393 - 2398 .
Christova R, Jones T, Wu P-J, Bolzer A, Costa-Pereira AP, Watling D, Kerr IM, Sheer D ( 2007 ) . P-STAT1 mediates higher-order chromatin remodelling of the human MHC in response to IFNgamma . J Cell Sci vol. 120 , ( Pt 18 ) 3262 - 3270 .
Donev R, Newall A, Thome J, Sheer D ( 2007 ) . A role for SC35 and hnRNPA1 in the determination of amyloid precursor protein isoforms . MOL PSYCHIATR vol. 12 , ( 7 ) 681 - 690 .
Mulholland PJ, Fiegler H, Mazzanti C, Gorman P, Sasieni P, Adams J, Jones TA, Babbage JW et al. ( 2006 ) . Genomic profiling identifies discrete deletions associated with translocations in glioblastoma multiforme . CELL CYCLE vol. 5 , ( 7 ) 783 - 791 .
Enukashvily N, Donev R, Sheer D, Podgornaya O ( 2005 ) . Satellite DNA binding and cellular localisation of RNA helicase P68 . J CELL SCI vol. 118 , ( 3 ) 611 - 622 .
Wang J, Shiels C, Sasieni P, Wu PJ, Islam SA, Freemont PS, Sheer D ( 2004 ) . Promyelocytic leukemia nuclear bodies associate with transcriptionally active genomic regions . J Cell Biol vol. 164 , ( 4 ) 515 - 526 .
SASIENI PD, Wu PJ, Wang J, Shields C, Islam SA, Freemont PS, Sheer D ( 2004 ) . Promyelocytic leukaemia nuclear bodies associate with transcriptionally active genomic regions . Journal of Cell Biology. vol. 164 , ( 4 ) 515 - 526 .
Donev R, Horton R, Beck S, Doneva T, Vatcheva R, Bowen WR, Sheer D ( 2003 ) . Recruitment of heterogeneous nuclear ribonucleoprotein A1 in vivo to the LMP/TAP region of the major histocompatibility complex . J Biol Chem vol. 278 , ( 7 ) 5214 - 5226 .
Donev RM, Doneva TA, Bowen WR, Sheer D ( 2002 ) . HnRNP-A1 binds directly to double-stranded DNA in vitro within a 36 bp sequence . MOL CELL BIOCHEM vol. 233 , ( 1-2 ) 181 - 185 .
Williams RRE, Broad S, Sheer D, Ragoussis J ( 2002 ) . Subchromosomal positioning of the epidermal differentiation complex (EDC) in keratinocyte and lymphoblast interphase nuclei . EXP CELL RES vol. 272 , ( 2 ) 163 - 175 .
Shiels C, Islam SA, Vatcheva R, Sasieni P, Sternberg MJ, Freemont PS, Sheer D ( 2001 ) . PML bodies associate specifically with the MHC gene cluster in interphase nuclei . J Cell Sci vol. 114 , ( Pt 20 ) 3705 - 3716 .
Sheer D, Volpi E, Beck S, Horton R, Donev R ( 2001 ) . Large-Scale chromatin structure and function in the Major Histocompatibility Complex . J MED GENET vol. 38 , S16 - S16 .
Sheer D, Volpi EV ( 2001 ) . Human Chromosomes (4th Edition) . Chromosome Research vol. 9 , ( 6 ) 474 - 474 .
Wu PJ, Bardos JI, Sheer D, Freemont P, Saha V ( 2001 ) . Expression and association of the human trithorax and polycomb group of proteins . BRIT J CANCER vol. 85 , 109 - 109 .
Schultz J, Jones T, Bork P, Sheer D, Blencke S, Steyrer S, Wellbrock U, Bevec D et al. ( 2001 ) . Erratum: Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 4q35 (Genomics (2001) 71:3 (368-370)) . Genomics vol. 74 , ( 2 )
Volpi EV, Sheer D, Uhlmann F ( 2001 ) . Cohesion, but not too close . Curr Biol vol. 11 , ( 10 )
Abdel-Rahman WM, Katsura K, Rens W, Gorman PA, Sheer D, Bicknell D, Bodmer WF, Arends MJ et al. ( 2001 ) . Spectral Karyotyping reveals a new subset of colorectal cancers characterized by balanced translocations . J PATHOL vol. 193 , 24A - 24A .
Abdel-Rahman WM, Katsura K, Rens W, Gorman PA, Sheer D, Bicknell D, Bodmer WF, Arends MJ et al. ( 2001 ) . Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement . P NATL ACAD SCI USA vol. 98 , ( 5 ) 2538 - 2543 .
Schultz J, Jones T, Bork P, Sheer D, Blencke S, Steyrer S, Wellbrock U, Bevec D et al. ( 2001 ) . Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 4q35 . GENOMICS vol. 71 , ( 3 ) 368 - 370 .
Sirivatanauksorn V, Sirivatanauksorn Y, Gorman PA, Davidson JM, Sheer D, Moore PS, Scarpa A, Edwards PAW et al. ( 2001 ) . Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping . INT J CANCER vol. 91 , ( 3 ) 350 - 358 .
Groet J, Ives JH, Jones TA, Chen L, Danton M, Flomen RH, Sheer D, Hrascan R et al. ( 2001 ) . Allelic loss in the gene-poor band 21q11 -> q21 in squamous non-small cell lung carcinoma: cloning of a novel ubiquitin specific protease from the minimal deleted region . CYTOGENET CELL GENET vol. 92 , ( 1-2 ) 16 - 16 .
SASIENI PD, Vatcheva R, Sheer D, Sternberg MJE, Freemont PS, Islam SA, Shiels C ( 2001 ) . PML bodies associate specifically with the MHC gene cluster in interphase nuclei . Journal of Cell Science vol. 114 , 3705 - 3716 .
Jones TA, Flomen RH, Senger G, Nižeti D, Sheer D ( 2000 ) . The homeobox gene MEIS1 is amplified in IMR-32 and highly expressed in other neuroblastoma cell lines . European Journal of Cancer vol. 36 , ( 18 ) 2368 - 2374 .
Taylor CP, Bown NP, McGuckin AG, Lunec J, Malcolm AJ, Pearson AD, Sheer D ( 2000 ) . Fluorescence in situ hybridization techniques for the rapid detection of genetic prognostic factors in neuroblastoma. United Kingdom Children's Cancer Study Group . Br J Cancer vol. 83 , ( 1 ) 40 - 49 .
Volpi EV, Chevret E, Jones T, Vatcheva R, Williamson J, Beck S, Campbell RD, Goldsworthy M et al. ( 2000 ) . Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei . Journal of Cell Science vol. 113 , ( 9 ) 1565 - 1576 .
Woodford-Richens K, Williamson J, Bevan S, Young J, Leggett B, Frayling I, Thway Y, Hodgson S et al. ( 2000 ) . Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium . Cancer Research vol. 60 , ( 9 ) 2477 - 2482 .
Wilson MJ, Torkar M, Haude A, Milne S, Jones T, Sheer D, Beck S, Trowsdale J ( 2000 ) . Plasticity in the organization and sequences of human KIR/ILT gene families . Proceedings of the National Academy of Sciences of the United States of America vol. 97 , ( 9 ) 4778 - 4783 .
Groet J, Ives JH, Jones TA, Danton M, Flomen RH, Sheer D, Hrašćan R, Pavelić K et al. ( 2000 ) . Narrowing of the region of allelic loss in 21q11-21 in squamous non- small cell lung carcinoma and cloning of a novel ubiquitin-specific protease gene from the deleted segment . Genes Chromosomes and Cancer vol. 27 , ( 2 ) 153 - 161 .
Chevret E, Volpi EV, Sheer D ( 2000 ) . Mini review: form and function in the human interphase chromosome . Cytogenet Cell Genet vol. 90 , ( 1-2 ) 13 - 21 .
Kashuba VI, Gizatullin RZ, Protopopov AI, Li J, Vorobieva NV, Fedorova L, Zabarovska VI, Muravenko OV et al. ( 1999 ) . Analysis of NotI linking clones isolated from human chromosome 3 specific libraries . Gene vol. 239 , ( 2 ) 259 - 271 .
Lamlum H, Ilyas M, Rowan A, Clark S, Johnson V, Bell J, Frayling I, Efstathiou J et al. ( 1999 ) . The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis . Nat Med vol. 5 , ( 9 ) 1071 - 1075 .
Roylance R, Gorman P, Harris W, Liebmann R, Barnes D, Hanby A, Sheer D ( 1999 ) . Comparative genomic hybridization of breast tumors stratified by histological grade reveals new insights into the biological progression of breast cancer . Cancer Research vol. 59 , ( 7 ) 1433 - 1436 .
Berchtold S, Jones T, Mühl-Zürbes P, Sheer D, Schuler G, Steinkasserer A ( 1999 ) . The human dendritic cell marker CD83 maps to chromosome 6p23 . Annals of Human Genetics vol. 63 , ( 2 ) 181 - 183 .
Mao X, Jones TA, Tomlinson I, Rowan AJ, Fedorova LI, Zelenin AV, Mao JI, Gutowski NJ et al. ( 1999 ) . Genetic aberrations in glioblastoma multiforme: Translocation of chromosome 10 in an O-2A-like cell line . British Journal of Cancer vol. 79 , ( 5-6 ) 724 - 731 .
Saurin AJ, Shiels C, Williamson J, Satijn DP, Otte AP, Sheer D, Freemont PS ( 1998 ) . The human polycomb group complex associates with pericentromeric heterochromatin to form a novel nuclear domain . J Cell Biol vol. 142 , ( 4 ) 887 - 898 .
Watt SM, Bühring H-J, Rappold I, Chan JY-H, Lee-Prudhoe J, Jones T, Zannettino ACW, Simmons PJ et al. ( 1998 ) . CD164, a Novel Sialomucin on CD34+ and Erythroid Subsets, Is Located on Human Chromosome 6q21 . Blood vol. 92 , ( 3 ) 849 - 866 .
Watt SM, Bühring HJ, Rappold I, Chan JYH, Lee-Prudhoe J, Jones T, Zannettino ACW, Simmons PJ et al. ( 1998 ) . Cd164, a novel sialomucin on cd34<sup>+</sup> and erythroid subsets, is located on human chromosome 6q21 . Blood vol. 92 , ( 3 ) 849 - 866 .
Herberg JA, Phillips S, Beck S, Jones T, Sheer D, Wu JJ, Prochazka V, Barr PJ et al. ( 1998 ) . Genomic structure and domain organisation of the human Bak gene . Gene vol. 211 , ( 1 ) 87 - 94 .
Herberg JA, Sgouros J, Jones T, Copeman J, Humphray SJ, Sheer D, Cresswell P, Beck S et al. ( 1998 ) . Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC . European Journal of Immunology vol. 28 , ( 2 ) 459 - 467 .
Chadwick BP, Williamson J, Sheer D, Frischauf AM ( 1998 ) . cDNA cloning and chromosomal mapping of a mouse gene with homology to NTPases . Mamm Genome vol. 9 , ( 2 ) 162 - 164 .
Chadwick BP, Heath SK, Williamson J, Obermayr F, Patel L, Sheer D, Frischauf AM ( 1998 ) . The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI) . Genomics vol. 47 , ( 1 ) 58 - 63 .
Howe K, Williamson J, Boddy N, Sheer D, Freemont P, Solomon E ( 1998 ) . The ubiquitin-homology gene PIC1: characterization of mouse (Pic1) and human (UBL1) genes and pseudogenes . Genomics vol. 47 , ( 1 ) 92 - 100 .
Grimwade D, Gorman P, Duprez E, Howe K, Langabeer S, Oliver F, Walker H, Culligan D et al. ( 1997 ) . Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia . Blood vol. 90 , ( 12 ) 4876 - 4885 .
Watt SM, Buhriig HJ, Chan JHY, Rappold I, Lee-Prudhoe J, Benton MA, Jones T, Zannettino ACW et al. ( 1997 ) . The sialomicin CD164, a negative regulator of haemopoiesis, is expressed by CD34<sup>+</sup> and erythroid subsets and is located on chromosome 6q21 . Experimental Hematology vol. 25 , ( 8 )
Thorpe KL, Gorman P, Thomas C, Sheer D, Trowsdale J, Beck S ( 1997 ) . Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene . Gene vol. 200 , ( 1-2 ) 177 - 183 .
Jones T, Sheer D, Bevec D, Kappel B, Hauber J, Steinkasserer A ( 1997 ) . The human HIV-1 Rev binding-protein hRIP/Rab (HRB) maps to chromosome 2q36 . Genomics vol. 40 , ( 1 ) 198 - 199 .
Roylance R, Spurr N, Sheer D ( 1997 ) . The genetic analysis of prostate carcinoma . Semin Cancer Biol vol. 8 , ( 1 ) 37 - 44 .
Fedorova L, Kost-Alimova M, Gizatullin RZ, Alimov A, Zabarovska VI, Szeles A, Protopopov AI, Vorobieva NV et al. ( 1997 ) . Assignment and ordering of twenty-three unique NotI-linking clones containing expressed genes including the guanosine 5'-monophosphate synthetase gene to human chromosome 3 . Eur J Hum Genet vol. 5 , ( 2 ) 110 - 116 .
Xu W, Liu L, Gorman PA, Sheer D, Emson PC ( 1997 ) . Assignment of the human creatine transporter type 2 (SLC6A10) to chromosome band 16p11.2 by in situ hybridization . Cytogenet Cell Genet vol. 76 , ( 1-2 )
McCusker D, Jones T, Sheer D, Trowsdale J ( 1997 ) . Genetic relationships of the genes encoding the human proteasome β subunits and the proteasome PA28 complex . Genomics vol. 45 , ( 2 ) 362 - 367 .
Flomen RH, Gorman PA, Vatcheva R, Groet J, Barišić I, Ligutić I, Sheer D, Nižetić D ( 1997 ) . Rieger syndrome locus: A new reciprocal translocation t(4;12)(q25;q15) and a deletion del(4)(q25q27) both break between markers D4S2945 and D4S193 . Journal of Medical Genetics vol. 34 , ( 3 ) 191 - 195 .
Ruhrberg C, Williamson JA, Sheer D, Watt FM ( 1996 ) . Chromosomal localisation of the human envoplakin gene (EVPL) to the region of the tylosis oesophageal cancer gene (TOCG) on 17q25 . Genomics vol. 37 , ( 3 ) 381 - 385 .
Jones T, Sheer D, Kapetanopoulos A, Hauber J, Bevec D, Steinkasserer A ( 1996 ) . The gene coding for human deoxyhypusine synthase (DHPS) maps to chromosome 19p13.11-p13.12 . Genomics vol. 35 , ( 3 ) 635 - 636 .
Williamson JA, Bosher JM, Skinner A, Sheer D, Williams T, Hurst HC ( 1996 ) . Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors . Genomics vol. 35 , ( 1 ) 262 - 264 .
Tassabehji M, Metcalfe K, Fergusson WD, Carette MJ, Dore JK, Donnai D, Read AP, Pröschel C et al. ( 1996 ) . LIM-kinase deleted in Williams syndrome . Nat Genet vol. 13 , ( 3 ) 272 - 273 .
Thomas HJW, Whitelaw SC, Cottrell SE, Murday VA, Tomlinson IPM, Markie D, Jones T, Bishop DT et al. ( 1996 ) . Genetic mapping of the hereditary mixed polyposis syndrome to chromosome 6q . American Journal of Human Genetics vol. 58 , ( 4 ) 770 - 776 .
Sheer D, Squire J ( 1996 ) . Clinical applications of genetic rearrangements in cancer . Semin Cancer Biol vol. 7 , ( 1 ) 25 - 32 .
Mao X, Jones TA, Williamson J, Gutowski NJ, Pröschel C, Noble M, Sheer D ( 1996 ) . Assignment of the human and mouse LIM-kinase genes (LIMK1; Limk1) to chromosome bands 7q11.23 and 5G1, respectively, by in situ hybridization . Cytogenetic and Genome Research vol. 74 , ( 3 ) 190 - 191 .
Wang XC, Katso R, Butler R, Hanby AM, Poulsom R, Jones T, Sheer D, Ganesan TS ( 1996 ) . H-RYK, an unusual receptor kinase: Isolation and analysis of expression in ovarian cancer . Molecular Medicine vol. 2 , ( 2 ) 189 - 203 .
Han X, Papadopoulos AJ, Jones TA, Sheer D, Raju KS ( 1996 ) . SR8 - The Establishment and Characterisation of a New Ovarian Carcinoma Cell Line and Xenograft Model . European Journal of Cancer vol. 32 , ( 1 ) 160 - 167 .
Waxman J, Sheer D ( 1995 ) . Is prostate cancer worth diagnosing? . Lancet vol. 346 , ( 8984 ) 1177 - 1178 .
Gill S, McManus AP, Crew AJ, Benjamin H, Sheer D, Gusterson BA, Pinkerton CR, Patel K et al. ( 1995 ) . Fusion of the EWS gene to a DNA segment from 9q22-31 in a human myxoid chondrosarcoma . Genes Chromosomes Cancer vol. 12 , ( 4 ) 307 - 310 .
Shipley J, Williams S, O'Byrne A, Kearney L, Jones T, Young B, Dyer M, Catovsky D et al. ( 1995 ) . Characterization of a t(I0; II) (pI3‐I4; qI4‐2I) in the monoblastic cell line U937 . Genes, Chromosomes and Cancer vol. 13 , ( 2 ) 138 - 142 .
Dunne J, Hanby AM, Poulsom R, Jones TA, Sheer D, Chin WG, Ming Da S, Zhao Q et al. ( 1995 ) . Molecular cloning and tissue expression of FAT, the human homologue of the drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule . Genomics vol. 30 , ( 2 ) 207 - 223 .
Steinkasserer A, Jones T, Sheer D, Koettnitz K, Hauber J, Bevec D ( 1995 ) . The eukaryotic cofactor for the human immunodeficiency virus type 1 (HIV-1) rev protein, eIF-5A, maps to chromosome 17p12-p13: Three eIF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2 . Genomics vol. 25 , ( 3 ) 749 - 752 .
Zarn JA, Jackson DG, Bell MV, Jones T, Weber E, Sheer D, Waibel R, Stahel RA ( 1995 ) . The small cell lung cancer antigen cluster-4 and the leukocyte antigen CD24 are allelic isoforms of the same gene (CD24) on chromosome band 6q21 . Cytogenetic and Genome Research vol. 70 , ( 1-2 ) 119 - 125 .
Shipley J, Sheer D, Dalton S, Treisman R, Patel K ( 1994 ) . Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively . Genomics vol. 23 , ( 3 ) 710 - 711 .
Belich MP, Glynne RJ, Senger G, Sheer D, Trowsdale J ( 1994 ) . Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins . Curr Biol vol. 4 , ( 9 ) 769 - 776 .
Delattre O, Zucman J, Melot T, Garau XS, Zucker JM, Lenoir GM, Ambros PF, Sheer D et al. ( 1994 ) . The Ewing family of tumors--a subgroup of small-round-cell tumors defined by specific chimeric transcripts . N Engl J Med vol. 331 , ( 5 ) 294 - 299 .
Sanséau P, Jackson A, Alderton RP, Beck S, Senger G, Sheer D, Kelly A, Trowsdale J ( 1994 ) . Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences . Mamm Genome vol. 5 , ( 8 ) 490 - 496 .
Senger G, Jones TA, Fidlerová H, Sanséau P, Trowsdale J, Duff M, Sheer D ( 1994 ) . Released chromatin: linearized DNA for high resolution fluorescence in situ hybridization . Hum Mol Genet vol. 3 , ( 8 ) 1275 - 1280 .
Xu W, Charles IG, Moncada S, Gorman P, Sheer D, Liu L, Emson P ( 1994 ) . Mapping of the genes encoding human inducible and endothelial nitric oxide synthase (NOS2 and NOS3) to the pericentric region of chromosome 17 and to chromosome 7, respectively . Genomics vol. 21 , ( 2 ) 419 - 422 .
Sanséau P, Jackson A, Senger G, Kelly A, Francis F, Sheer D, Trowsdale J ( 1994 ) . Cloning of the region between HLA-DMB and LMP2 in the human major histocompatibility complex . Hum Immunol vol. 40 , ( 1 ) 1 - 7 .
Emslie EA, Jones TA, Sheer D, Keyse SM ( 1994 ) . The CL100 gene, which encodes a dual specificity (Tyr/Thr) MAP kinase phosphatase, is highly conserved and maps to human chromosome 5q34 . Human Genetics vol. 93 , ( 5 ) 513 - 516 .
Samec S, Jones TA, Corlet J, Scherly D, Sheer D, Wood RD, Clarkson SG ( 1994 ) . The human gene for xeroderma pigmentosum complementation group g (xpg) maps to 13q33 by fluorescence in situ hybridization . Genomics vol. 21 , ( 1 ) 283 - 285 .
Borrow J, Shipley J, Howe K, Kiely F, Goddard A, Sheer D, Srivastava A, Antony AC et al. ( 1994 ) . Molecular analysis of simple variant translocations in acute promyelocytic leukemia . Genes Chromosomes Cancer vol. 9 , ( 4 ) 234 - 243 .
Taylor CP, McGuckin AG, Bown NP, Reid MM, Malcolm AJ, Pearson AD, Sheer D ( 1994 ) . Rapid detection of prognostic genetic factors in neuroblastoma using fluorescence in situ hybridisation on tumour imprints and bone marrow smears. United Kingdom Children's Cancer Study Group . Br J Cancer vol. 69 , ( 3 ) 445 - 451 .
Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, Carrozzo R, Patel K et al. ( 1994 ) . Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire . Hum Mol Genet vol. 3 , ( 2 ) 229 - 235 .
Fidlerová H, Senger G, Kost M, Sanseau P, Sheer D ( 1994 ) . Two simple procedures for releasing chromatin from routinely fixed cells for fluorescence in situ hybridization . Cytogenet Cell Genet vol. 65 , ( 3 ) 203 - 205 .
Zucman J, Melot T, Desmaze C, Ghysdael J, Plougastel B, Peter M, Zucker JM, Triche TJ et al. ( 1993 ) . Combinatorial generation of variable fusion proteins in the Ewing family of tumours . EMBO J vol. 12 , ( 12 ) 4481 - 4487 .
Patel K, Sheer D, Hampton GM ( 1993 ) . "Junction trapping". A simple PCR-based method for the isolation of YAC-insert termini . Genet Anal Tech Appl vol. 10 , ( 2 ) 42 - 48 .
Markie D, Ragoussis J, Senger G, Rowan A, Sansom D, Trowsdale J, Sheer D, Bodmer WF ( 1993 ) . New vector for transfer of yeast artificial chromosomes to mammalian cells . Somat Cell Mol Genet vol. 19 , ( 2 ) 161 - 169 .
Yon J, Jones T, Garson K, Sheer D, Fried M ( 1993 ) . The organization and conservation of the human surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1 . Human Molecular Genetics vol. 2 , ( 3 ) 237 - 240 .
Ward JRT, Cottrell S, Thomas HJW, Jones TA, Howe CM, Hampton GM, Deaven L, Sheer D et al. ( 1993 ) . A long-range restriction map of human chromosome 5q21-q23 . Genomics vol. 17 , ( 1 ) 15 - 24 .
Abrahamsen TG, Wesenberg F, Mørk S, Allen J, Hayes R, DaRosso R, Nirenberg A, Ali-Osman F et al. ( 1993 ) . Abstracts for the Tenth International Conference on Brain Tumour Research and Therapy . Journal of Neuro-Oncology vol. 15 , ( Suppl 1 ) s1 - s30 .
Taylor C, Patel K, Jones T, Kiely F, De Stavola BL, Sheer D ( 1993 ) . Diagnosis of ewing’s sarcoma and peripheral neuroectodermal tumour based on the detection of t(Ll;22) using fluorescence in situ hybridisation . British Journal of Cancer vol. 67 , ( 1 ) 128 - 133 .
Senger G, Ragoussis J, Trowsdale J, Sheer D ( 1993 ) . Fine mapping of the human MHC class II region within chromosome band 6p21 and evaluation of probe ordering using interphase fluorescence in situ hybridization . Cytogenet Cell Genet vol. 64 , ( 1 ) 49 - 53 .
Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings AA, Spurr NK, Sheer D, Cohen PTW ( 1993 ) . Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23→q31 and 8p12→p11.2, respectively . Cytogenetic and Genome Research vol. 63 , ( 1 ) 35 - 4l .
Shipley JM, Jones TA, Patel K, Kiely FM, De Stavola BL, Sheer D ( 1993 ) . Ordering of probes surrounding the ewing’s sarcoma breakpoint on chromosome 22 using fluorescent in situ hybridization to interphase nuclei . Cytogenetic and Genome Research vol. 64 , ( 3-4 ) 233 - 239 .
Xu W, Gorman P, Sheer D, Bates G, Kishimoto J, Lizhi L, Emson P ( 1993 ) . Regional localization of the gene coding for human brain nitric oxide synthase (NOS1) to 12q24.2-->24.31 by fluorescent in situ hybridization . Cytogenet Cell Genet vol. 64 , ( 1 ) 62 - 63 .
Barnett PS, Jones TA, McGregor AM, Banga JP, Sheer D ( 1993 ) . Regional sublocalization of the human thyroid peroxidase gene (TPO) by tritium and fluorescence in situ hybridization to chromosome 2p25→p24 . Cytogenetic and Genome Research vol. 62 , ( 4 ) 188 - 189 .
Cole CG, Patel K, Shipley J, Sheer D, Bobrow M, Bentley DR, Dunham I ( 1992 ) . Identification of region-specific yeast artificial chromosomes using pools of Alu element-mediated polymerase chain reaction probes labeled via linear amplification . Genomics vol. 14 , ( 4 ) 931 - 938 .
Jenkins JR, Ayton P, Jones T, Davies SL, Simmons DL, Harris AL, Sheer D, Hickson ID ( 1992 ) . Isolation of cDNA clones encoding the β isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24 . Nucleic Acids Research vol. 20 , ( 21 ) 5587 - 5592 .
Ragoussis J, Senger G, Mockridge I, Sanseau P, Ruddy S, Dudley K, Sheer D, Trowsdale J ( 1992 ) . A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11 . Genomics vol. 14 , ( 3 ) 673 - 679 .
Calabrese G, Palka G, Westbrook CA, Sheer D ( 1992 ) . Complex translocation involving Ph chromosome in a patient with typical chronic myelogenous leukemia . Cancer Genet Cytogenet vol. 63 , ( 1 ) 52 - 55 .
Lennard A, Gorman P, Carrier M, Griffiths S, Scotney H, Sheer D, Solari R ( 1992 ) . Cloning and chromosome mapping of the human interleukin-1 receptor antagonist gene . Cytokine vol. 4 , ( 2 ) 83 - 89 .
Markie D, Jones TA, Sheer D, Bodmer WF ( 1992 ) . A somatic cell hybrid panel for regional mapping of human chromosome 18 . Genomics vol. 14 , ( 2 ) 431 - 436 .
Hampton GM, Ward JRTJ, Cottrell S, Howe K, Thomas HJW, Ballhausen WG, Jones T, Sheer D et al. ( 1992 ) . Yeast artificial chromosomes for the molecular analysis of the familial polyposis APC gene region . Proceedings of the National Academy of Sciences of the United States of America vol. 89 , ( 17 ) 8249 - 8253 .
Heard E, Williams SV, Sheer D, Fried M ( 1991 ) . Gene amplification accompanied by the loss of a chromosome containing the native allele and the appearance of the amplified DNA at a new chromosomal location . Proc Natl Acad Sci U S A vol. 88 , ( 18 ) 8242 - 8246 .
Patel K, Cox R, Shipley J, Kiely F, Frazer K, Cox DR, Lehrach H, Sheer D ( 1991 ) . A novel and rapid method for isolating sequences adjacent to rare cutting sites and their use in physical mapping . Nucleic Acids Res vol. 19 , ( 16 ) 4371 - 4375 .
Dietrich A, Kioschis P, Monaco AP, Gross B, Korn B, Williams SV, Sheer D, Heitz D et al. ( 1991 ) . Molecular cloning and analysis of the fragile X region in man . Nucleic Acids Res vol. 19 , ( 10 ) 2567 - 2572 .
Gorman PA, Malone M, Pritchard J, Sheer D ( 1991 ) . Cytogenetic analysis of primitive neuroectodermal tumors. Absence of the t(11;22) in two of three cases and a review of the literature . Cancer Genet Cytogenet vol. 51 , ( 1 ) 13 - 22 .
Williams SV, Jones TA, Cottrell S, Zehetner G, Varesco L, Ward T, Thomas H, Lawson PA et al. ( 1991 ) . Fine Mapping of Probes in the Adenomatous Polyposis Coli Region of Chromosome 5 by In Situ Hybridization . Genes, Chromosomes and Cancer vol. 3 , ( 5 ) 382 - 389 .
Ragoussis J, Jones TA, Sheer D, Shrimpton AE, Goodfellow PN, Trowsdale J, Ziegler A ( 1991 ) . Isolation of probes specific to human chromosomal region 6p21 from immunoselected irradiation-fusion gene transfer hybrids . Genomics vol. 10 , ( 3 ) 598 - 607 .
Hämäläinen ER, Jones TA, Sheer D, Taskinen K, Pihlajaniemi T, Kivirikko KI ( 1991 ) . Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2 . Genomics vol. 11 , ( 3 ) 508 - 516 .
Pajunen L, Jones TA, Goddard A, Sheer D, Solomon E, Pihlajaniemi T, Kivirikko KI ( 1991 ) . Regional assignment of the human gene coding for a multifunctional polypeptide (P4HB) acting as the β-subunit of prolyl 4-hydroxylase and the enzyme protein disulfide isomerase to 17q25 . Cytogenetic and Genome Research vol. 56 , ( 3-4 ) 165 - 168 .
Borrow J, Goddard AD, Sheer D, Solomon E ( 1990 ) . Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17 . Science vol. 249 , ( 4976 ) 1577 - 1580 .
Gorman PA, Malone M, Pritchard J, Sheer D ( 1990 ) . Deletion of part of the short arm of chromosome 17 in a congenital fibrosarcoma . Cancer Genet Cytogenet vol. 48 , ( 2 ) 193 - 198 .
Myers JC, Jones TA, Pohjolainen ER, Kadri AS, Goddard AD, Sheer D, Solomon E, Pihlajaniemi T ( 1990 ) . Molecular cloning of α5(IV) collagen and assignment of the gene to the region of the X chromosome containing the Alport syndrome locus . American Journal of Human Genetics vol. 46 , ( 6 ) 1024 - 1033 .
Sheer D, Gorman PA, Whelan R, Hill BT ( 1990 ) . Cytogenetic analysis of a cell line established from a Krukenberg tumor . Cancer Genet Cytogenet vol. 46 , ( 1 ) 71 - 74 .
Edwards Y, Williams S, West L, Lipowicz S, Sheer D, Attwood J, Spurr N, Sarkar R et al. ( 1990 ) . The polymorphic human DNA sequence D8S8 assigned to 8q13-21.1, close to the carbonic anhydrase gene cluster, by isotopic and nonisotopic in situ hybridization and by linkage analysis . Ann Hum Genet vol. 54 , ( 2 ) 131 - 139 .
Lord DK, Cross NC, Bevilacqua MA, Rider SH, Gorman PA, Groves AV, Moss DW, Sheer D et al. ( 1990 ) . Type 5 acid phosphatase. Sequence, expression and chromosomal localization of a differentiation-associated protein of the human macrophage . Eur J Biochem vol. 189 , ( 2 ) 287 - 293 .
Jones TA, da Cruz e Silva EF, Spurr NK, Sheer D, Cohen PTW ( 1990 ) . Localisation of the gene encoding the catalytic γ subunit of phosphorylase kinase to human chromosome bands 7p12-q21 . BBA - Gene Structure and Expression vol. 1048 , ( 1 ) 24 - 29 .
Wynford-Thomas D, Bond JA, Wyllie FS, Burns JS, Williams ED, Jones T, Sheer D, Lemoine NR ( 1990 ) . Conditional immortalization of human thyroid epithelial cells: A tool for analysis of oncogene action . Molecular and Cellular Biology vol. 10 , ( 10 ) 5365 - 5377 .
Barker HM, Jones TA, da Cruz e Silva EF, Spurr NK, Sheer D, Cohen PTW ( 1990 ) . Localization of the gene encoding a type I protein phosphatase catalytic subunit to human chromosome band 11q13 . Genomics vol. 7 , ( 2 ) 159 - 166 .
Pajunen L, Jones TA, Helaakoski T, Pihlajaniemi T, Solomon E, Sheer D, Kivirikko KI ( 1989 ) . Assignment of the gene coding for the α-subunit of propyl 4-hydroxylase to human chromosome region 10q21.3-23.1 . American Journal of Human Genetics vol. 45 , ( 6 ) 829 - 834 .
Varesco L, Thomas HJ, Cottrell S, Murday V, Fennell SJ, Williams S, Searle S, Sheer D et al. ( 1989 ) . CpG island clones from a deletion encompassing the gene for adenomatous polyposis coli . Proc Natl Acad Sci U S A vol. 86 , ( 24 ) 10118 - 10122 .
Davies AA, Moss SE, Crompton MR, Jones TA, Spurr NK, Sheer D, Kozak C, Crumpton MJ ( 1989 ) . The gene coding for the p68 calcium-binding protein is localised to bands q32-q34 of human chromosome 5, and to mouse chromosome 11 . Human Genetics vol. 82 , ( 3 ) 234 - 238 .
Yon J, Palmer RW, Sheer D, Fried M ( 1989 ) . Localization of the Surfeit gene cluster containing the ribosomal protein gene L7a to chromosome bands 9q33-34 . Ann Hum Genet vol. 53 , ( 2 ) 149 - 155 .
Moore G, Hedge PJ, Rider SH, Xu W, Hing S, Palmer R, Sheer D, Solomon E ( 1989 ) . Multiple tandem 18-kb sequences clustered in the region of the acute promyelocytic leukemia breakpoint on chromosome 17 . Genomics vol. 4 , ( 2 ) 152 - 161 .
Goodfellow PJ, Nevanlinna HA, Gorman P, Sheer D, Lam G, Goodfellow PN ( 1989 ) . Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2 . Ann Hum Genet vol. 53 , ( 1 ) 15 - 22 .
Lemoine NR, Mayall ES, Jones T, Sheer D, McDermid S, Kendall-Taylor P, Wynford-Thomas D ( 1989 ) . Characterisation of human thyroid epithelial cells immortalised in vitro by simian virus 40 DNA transfection . British Journal of Cancer vol. 60 , ( 6 ) 897 - 903 .
Shipley J, Sheer D ( 1989 ) . Deletion of c-ets1 and T3 gamma loci from the 11q- chromosome in the human monoblastic cell line U937 . Leuk Res vol. 13 , ( 6 ) 445 - 450 .
MURDAY V, COTTRELL S, BODMER WF, SHEER D, JONES TA, VARESCO L, FRISCHAUF AM, THOMAS HJ et al. ( 1989 ) . FINE LINKAGE MAP AROUND THE ADENOMATOUS POLYPOSIS (APC) GENE . CYTOGENETICS AND CELL GENETICS . vol. 51 , 1049 - 1049 .
Xu WM, Gorman PA, Rider SH, Hedge PJ, Moore G, Prichard C, Sheer D, Solomon E ( 1988 ) . Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer . Proc Natl Acad Sci U S A vol. 85 , ( 22 ) 8563 - 8567 .
Whelan R, Gibby E, Sheer D, Povey S, Hill BT ( 1988 ) . Characterization of a continuous cell line in culture established from a Krukenberg tumour of the ovary arising from a primary gastric adenocarcinoma . Eur J Cancer Clin Oncol vol. 24 , ( 9 ) 1397 - 1408 .
Shipley JM, Sheppard DM, Sheer D ( 1988 ) . Karyotypic analysis of the human monoblastic cell line U937 . Cancer Genet Cytogenet vol. 30 , ( 2 ) 277 - 284 .
Williams BP, Daniels GL, Pym B, Sheer D, Povey S, Okubo Y, Andrews PW, Goodfellow PN ( 1988 ) . Biochemical and genetic analysis of the OKa blood group antigen . Immunogenetics vol. 27 , ( 5 ) 322 - 329 .
Sewell WA, Palmer RW, Spurr NK, Sheer D, Brown MH, Bell Y, Crumpton MJ ( 1988 ) . The human LFA-3 gene is located at the same chromosome band as the gene for its receptor CD2 . Immunogenetics vol. 28 , ( 4 ) 278 - 282 .
Swallow DM, Gendler S, Griffiths B, Kearney A, Povey S, Sheer D, Palmer RW, Taylor-Papadimitriou J ( 1987 ) . The hypervariable gene locus PUM, which codes for the tumour associated epithelial mucins, is located on chromosome 1, within the region 1q21-24 . Ann Hum Genet vol. 51 , ( 4 ) 289 - 294 .
Willison K, Kelly A, Dudley K, Goodfellow P, Spurr N, Groves V, Gorman P, Sheer D et al. ( 1987 ) . The human homologue of the mouse t-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region . EMBO J vol. 6 , ( 7 ) 1967 - 1974 .
Sheer D, Sheppard DM, Gorman PA, Ward B, Whelan RD, Hill BT ( 1987 ) . Cytogenetic analysis of four human ovarian carcinoma cell lines . Cancer Genet Cytogenet vol. 26 , ( 2 ) 339 - 349 .
Brown MH, Gorman PA, Sewell WA, Spurr NK, Sheer D, Crumpton MJ ( 1987 ) . The gene coding for the human T-lymphocyte CD2 antigen is located on chromosome 1p . Hum Genet vol. 76 , ( 2 ) 191 - 195 .
Rider SH, Gorman PA, Shipley JM, Moore G, Vennstrom B, Solomon E, Sheer D ( 1987 ) . Localization of the oncogene c-erbA2 to human chromosome 3 . Ann Hum Genet vol. 51 , ( 2 ) 153 - 160 .
Martin D, Tucker DF, Gorman P, Sheer D, Spurr NK, Trowsdale J ( 1987 ) . The human placental alkaline phosphatase gene and related sequences map to chromosome 2 band q37 . Ann Hum Genet vol. 51 , ( 2 ) 145 - 152 .
Hill BT, Whelan RD, Gibby EM, Sheer D, Hosking LK, Shellard SA, Rupniak HT ( 1987 ) . Establishment and characterisation of three new human ovarian carcinoma cell lines and initial evaluation of their potential in experimental chemotherapy studies . Int J Cancer vol. 39 , ( 2 ) 219 - 225 .
Rider SH, Bailey CJ, Voss R, Sheer D, Hiorns LR, Solomon E ( 1987 ) . RFLP for the human erb-A1 gene . Nucleic Acids Res vol. 15 , ( 2 )
Krissansen GW, Gorman PA, Kozak CA, Spurr NK, Sheer D, Goodfellow PN, Crumpton MJ ( 1987 ) . Chromosomal locations of the gene coding for the CD3 (T3) gamma subunit of the human and mouse CD3/T-cell antigen receptor complexes . Immunogenetics vol. 26 , ( 4-5 ) 258 - 266 .
Eridani S, Gorman P, Sheer D, Duncombe AS, Glass UH, Shivji MK ( 1987 ) . Monosomy 7 and Ph-positive acute lymphoblastic leukaemia: cytogenetic and molecular aspects . Leuk Res vol. 11 , ( 11 ) 965 - 969 .
Spurr NK, Durbin H, Sheer D, Parkar M, Bobrow L, Bodmer WF ( 1986 ) . Characterization and chromosomal assignment of a human cell surface antigen defined by the monoclonal antibody AUAI . Int J Cancer vol. 38 , ( 5 ) 631 - 636 .
Chan LC, Sheer D, Drysdale HC, Bevan D, Greaves MF ( 1985 ) . Monosomy 7 and multipotential stem cell transformation . Br J Haematol vol. 61 , ( 3 ) 531 - 539 .
Sheer D ( 1985 ) . Genetic aspects of carcinogenesis . Br J Surg vol. 72 Suppl , S39 - S41 .
Benchimol S, Lamb P, Crawford LV, Sheer D, Shows TB, Bruns GA, Peacock J ( 1985 ) . Transformation associated p53 protein is encoded by a gene on human chromosome 17 . Somat Cell Mol Genet vol. 11 , ( 5 ) 505 - 510 .
Sheer D, Lister TA, Amess J, Solomon E ( 1985 ) . Incidence of the 15q+;17q- chromosome translocation in acute promyelocytic leukaemia (APL) . Br J Cancer vol. 52 , ( 1 ) 55 - 58 .
Sheer D, Sheppard DM, le Beau M, Rowley JD, San Roman C, Solomon E ( 1985 ) . Localization of the oncogene c-erbA1 immediately proximal to the acute promyelocytic leukaemia breakpoint on chromosome 17 . Ann Hum Genet vol. 49 , ( 3 ) 167 - 171 .
Paraskeva C, Buckle BG, Sheer D, Wigley CB ( 1984 ) . The isolation and characterization of colorectal epithelial cell lines at different stages in malignant transformation from familial polyposis coli patients . Int J Cancer vol. 34 , ( 1 ) 49 - 56 .
Spurr NK, Solomon E, Jansson M, Sheer D, Goodfellow PN, Bodmer WF, Vennstrom B ( 1984 ) . Chromosomal localisation of the human homologues to the oncogenes erbA and B . EMBO J vol. 3 , ( 1 ) 159 - 163 .
Solomon E, Hiorns L, Sheer D, Rowe D ( 1984 ) . Confirmation that the type I collagen gene on chromosome 17 is COL1A1 (alpha 1(I), using a human genomic probe . Ann Hum Genet vol. 48 , ( 1 ) 39 - 42 .
Sheer D, Hiorns LR, Stanley KF, Goodfellow PN, Swallow DM, Povey S, Heisterkamp N, Groffen J et al. ( 1983 ) . Genetic analysis of the 15;17 chromosome translocation associated with acute promyelocytic leukemia . Proc Natl Acad Sci U S A vol. 80 , ( 16 ) 5007 - 5011 .
Goodfellow P, Banting G, Sheer D, Ropers HH, Caine A, Ferguson-Smith MA, Povey S, Voss R ( 1983 ) . Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome . Nature vol. 302 , ( 5906 ) 346 - 349 .
Bai Y, Sheer D, Hiorns L, Knowles RW, Tunnacliffe A ( 1982 ) . A monoclonal antibody recognizing a cell surface antigen coded for by a gene on human chromosome 17 . Ann Hum Genet vol. 46 , ( 4 ) 337 - 347 .
Sheer D, Solomon E, Greaves MF, Lister TA ( 1982 ) . 15/17 chromosome translocation in acute promyelocytic leukemia . Cancer Genet Cytogenet vol. 5 , ( 4 ) 353 - 354 .
Sheer D, Brown RM, Bobrow M ( 1982 ) . Carcinoembryonic antigen (CEA) expression in somatic cell hybrids . Somatic Cell Genet vol. 8 , ( 1 ) 1 - 13 .