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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Madubashini Peiris

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Leech T, Peiris M ( 2024 ) . Mucosal neuroimmune mechanisms in gastro-oesophageal reflux disease (GORD) pathogenesis . Journal of Gastroenterology1 - 14 .
Ustaoglu A, Daudali FA, D’afflitto M, Murtough S, Lee C, Moreno E, Blaydon DC, Kelsell DP et al. ( 2023 ) . Identification of novel immune cell signature in gastroesophageal reflux disease: altered mucosal mast cells and dendritic cell profile . Frontiers in Immunology vol. 14 ,
Aktar R, Rondinelli S, Peiris M ( 2023 ) . GPR84 in physiology—Many functions in many tissues . British Journal of Pharmacology
da Silva Watanabe P, Cavichioli AM, D'Arc de Lima Mendes J, Aktar R, Peiris M, Blackshaw LA, de Almeida Araújo EJ ( 2023 ) . Colonic motility adjustments in acute and chronic DSS-induced colitis . Life Sciences vol. 321 ,
Besa E, Tembo MJ, Mulenga C, Mweetwa M, Choudhry N, Chandwe K, Storer C, Head R et al. ( 2023 ) . Potential determinants of low circulating glucagon‐like peptide 2 concentrations in Zambian children with non‐responsive stunting . Quarterly Journal of Experimental Physiology and Cognate Medical Sciences vol. 108 , ( 4 ) 568 - 580 .
Ustaoglu A, Daudali FA, Moreno E, Woodland PJ, Peiris M, Sifrim D ( 2022 ) . Su1200: ESOPHAGEAL MUCOSAL AND MOLECULAR DIFFERENCES BETWEEN FUNCTIONAL HEARTBURN AND HEALTHY ASYMPTOMATIC SUBJECTS . Gastroenterology vol. 162 , ( 7 ) s - 543 .
Ustaoglu A, Moreno E, Lee C, Peiris M, Sifrim D, Woodland PJ ( 2022 ) . Su1210: RNA SEQUENCING REVEALS FEW MOLECULAR DIFFERENCES IN OESOPHAGEAL MUCOSA BETWEEN PATIENTS WITH EROSIVE AND NON-EROSIVE REFLUX DISEASE . Gastroenterology vol. 162 , ( 7 )
d’Afflitto M, Upadhyaya A, Green A, Peiris M ( 2022 ) . Association Between Sex Hormone Levels and Gut Microbiota Composition and Diversity—A Systematic Review . Journal of Clinical Gastroenterology vol. 56 , ( 5 ) 384 - 392 .
Hornsby E, King HW, Peiris M, Buccafusca R, Lee WJ, Wing ES, Blackshaw LA, Lindsay JO et al. ( 2022 ) . The cation channel TRPM8 influences the differentiation and function of human monocytes . Journal of Leukocyte Biology vol. 112 , ( 3 ) 365 - 381 .
Ustaoglu A, Moreno E, Lee C, Peiris M, Sifrim D, Woodland PJ ( 2022 ) . RNA SEQUENCING REVEALS FEW MOLECULAR DIFFERENCES IN OESOPHAGEAL MUCOSA BETWEEN PATIENTS WITH EROSIVE AND NON-EROSIVE REFLUX DISEASE . GASTROENTEROLOGY . vol. 162 , S548 - S549 .
Takahashi K, Khwaja IG, Schreyer JR, Bulmer D, Peiris M, Terai S, Aziz Q ( 2021 ) . Post-inflammatory Abdominal Pain in Patients with Inflammatory Bowel Disease During Remission: A Comprehensive Review . Crohn's & Colitis 360 vol. 3 , ( 4 )
Peiris M, Weerts ZZRM, Aktar R, Masclee AAM, Blackshaw A, Keszthelyi D ( 2021 ) . A putative anti‐inflammatory role for TRPM8 in irritable bowel syndrome—An exploratory study . Neurogastroenterology & Motility vol. 33 , ( 9 )
Peiris M, Aktar R, Reed D, Cibert-Goton V, Zdanaviciene A, Halder W, Robinow A, Corke S et al. ( 2021 ) . Decoy bypass for appetite suppression in obese adults: role of synergistic nutrient sensing receptors GPR84 and FFAR4 on colonic endocrine cells . Gut vol. 71 , ( 5 ) 928 - 937 .
Ustaoglu A, Lee C, Sifrim D, Peiris M, Woodland PJ ( 2021 ) . 789 HEARTBURN SENSATION IN NON-EROSIVE REFLUX DISEASE: DISTINCTIVE PATTERN OF SUPERFICIAL SENSORY NERVES EXPRESSING TRPV1 AND EPITHELIAL CELLS EXPRESSING ASIC3 RECEPTORS . Gastroenterology vol. 160 , ( 6 )
Baumard L, Weerts ZZRM, Masclee AAM, Keszthelyi D, Michael-Titus AT, Peiris M ( 2021 ) . Effect of Obesity on the Expression of Nutrient Receptors and Satiety Hormones in the Human Colon . Nutrients vol. 13 , ( 4 )
Ustaoglu A, Sawada A, Lee C, Lei W-Y, Chen C-L, Hackett R, Sifrim D, Peiris M et al. ( 2021 ) . Heartburn sensation in nonerosive reflux disease: pattern of superficial sensory nerves expressing TRPV1 and epithelial cells expressing ASIC3 receptors . AJP Gastrointestinal and Liver Physiology vol. 320 , ( 5 ) g804 - g815 .
Baumard L, Weerts ZZ, Masclee A, Keszthelyi D, Michael-Titus A, Peiris M ( 2021 ) . Effect of obesity on the expression of nutrient receptors and satiety hormones in the human colon . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 33 ,
Ustaoglu A, D'afflitto M, Peiris M, Woodland P, Sifrim D ( 2021 ) . RNA sequencing of the oesophageal mucosa of patients with heartburn identifies dendritic cell population in functional heartburn . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 33 ,
Ustaoglu A, Woodland PJ, Peiris M, Lee C, Nikaki K, Sifrim D ( 2020 ) . Sa1216 IN PATIENTS WITH HEARTBURN, SUPERFICIAL MUCOSAL AFFERENT NERVES EXPRESS TRANSIENT RECEPTOR POTENTIAL VANILLOID SUBFAMILY MEMBER-1 (TRPV1) . Gastroenterology vol. 158 , ( 6 )
Myers R, Balakrishna D, Fabrey R, Gopal S, Howitt M, Peiris M, Raveglia L, Sabat M et al. ( 2020 ) . Direct activation of tuft cells by transient receptor potential subfamily M member 5 (TRPM5) agonists increases colonic motility and secretion through induction of a Th2 cytokine response and mobilization of non-neuronal acetylcholine . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 32 ,
Aktar R, Parkar N, Stentz R, Baumard L, Parker A, Goldson A, Brion A, Carding S et al. ( 2020 ) . Human resident gut microbe<i>Bacteroides thetaiotaomicron</i>regulates colonic neuronal innervation and neurogenic function . GUT MICROBES vol. 11 , ( 6 ) 1745 - 1757 .
Ustaoglu A, Woodland PJ, Peiris M, Lee C, Nikaki K, Sifrim D ( 2020 ) . IN PATIENTS WITH HEARTBURN, SUPERFICIAL MUCOSAL AFFERENT NERVES EXPRESS TRANSIENT RECEPTOR POTENTIAL VANILLOID SUBFAMILY MEMBER-1 (TRPV1) . GASTROENTEROLOGY . vol. 158 , S315 - S316 .
Ustaoglu A, Woodland P, Peiris M, Sifrim D ( 2020 ) . Patients with heartburn express transient receptor potential vanilloid subfamily member-1 (TRPV1) on superficial afferent oesophageal nerve fibres . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 32 ,
AKTAR R, PEIRIS M, FIKREE A, Eaton S, Kritas S, Kentish S, Araujo E, Bacarin C et al. ( 2019 ) . A novel role for the extracellular matrix glycoprotein-Tenascin-X in gastric function . J Physiol Article 10.1113/JP277195 ,
Aktar R, Parkar N, Stentz R, Parker A, Brion A, Goldson A, Carding S, Blackshaw A et al. ( 2019 ) . Conventionalisation of germ free mice with bacteriodes thetaiotaomicron induces proliferation of inhibitory motor neurones and specifically alters proximal colonic motility . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 31 ,
Weerts ZZ, Peiris M, Xu P, Vork L, Wilms E, Elizalde M, Jonkers D, Blackshaw A et al. ( 2019 ) . TRPM8 and TRPA1 mRNA expression in colonic biopsies of patients with irritable bowel syndrome and healthy controls . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 31 ,
Peiris M, Aktar R, Raynel S, Hao Z, Mumphrey MB, Berthoud H-R, Blackshaw LA ( 2018 ) . Effects of Obesity and Gastric Bypass Surgery on Nutrient Sensors, Endocrine Cells, and Mucosal Innervation of the Mouse Colon . Nutrients vol. 10 , ( 10 )
Aktar R, Peiris M, Fikree A, Cibert‐Goton V, Walmsley M, Tough IR, Watanabe P, Araujo EJA et al. ( 2018 ) . The extracellular matrix glycoprotein tenascin‐X regulates peripheral sensory and motor neurones . The Journal of Physiology vol. 596 , ( 17 ) 4237 - 4251 .
Aktar R, Watanabe P, Cibert-Goton V, Peiris M, Fikree A, Araujo E, Voermans N, Aziz Q et al. ( 2018 ) . Mo1599 - Abdominal Pain in Hypermobility-Type Ehlers Danlos Syndrome is Associated with Proliferation and Hypersensitivity of Colonic Nociceptive Nerve Endings . Gastroenterology vol. 154 , ( 6 )
( 2017 ) . Exam 2: Superficial Esophageal Mucosal Afferent Nerves May Contribute to Reflux Hypersensitivity in Nonerosive Reflux Disease . Gastroenterology vol. 153 , ( 5 )
Woodland P, Ooi JLS, Grassi F, Nikaki K, Lee C, Evans JA, Koukias N, Triantos C et al. ( 2017 ) . Superficial Esophageal Mucosal Afferent Nerves May Contribute to Reflux Hypersensitivity in Nonerosive Reflux Disease . Gastroenterology vol. 153 , ( 5 ) 1230 - 1239 .
Peiris M, Hockley JR, Reed DE, Smith ESJ, Bulmer DC, Blackshaw LA ( 2017 ) . Peripheral KV7 channels regulate visceral sensory function in mouse and human colon . Mol Pain vol. 13 , 1744806917709371 - 1744806917709371 .
Woodland PJ, Grassi F, Peiris M, Aktar R, Ooi JL, Evans J, Lee C, McDonald SA et al. ( 2017 ) . Sa1150 Innervation Pattern of the Distal Mucosal Squamous Epithelium May Underlie Hyposensitivity to Acid Reflux in Patients with Barrett’s Oesophagus . Gastroenterology . vol. 152 ,
Aktar R, Watanabe P, Cibert-Goton V, Peiris M, Fikree A, De Almeida EA, Voermans N, Aziz Q et al. ( 2017 ) . Abdominal pain in hypermobile Ehlers Danlos Syndrome (hEDS) may be associated with proliferation of colonic nociceptive nerve endings . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 29 , 13 - 13 .
Peiris M, Kahlon RK, Aktar R, Raynel S, Blackshaw LA ( 2017 ) . Expression and neurochemical identity of sensory fibres is altered in Inflammatory Bowel Disease (IBD) . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 29 , 27 - 28 .
Peiris M, Hao Z, Mumphrey M, Berthoud H-R, Blackshaw LA ( 2017 ) . Long-term effects of Roux-en-Y gastric bypass surgery on colonic nutrient-sensing receptors and enteroendocrine cells . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 29 , 19 - 20 .
Peiris M, Corke S, Blackshaw LA ( 2017 ) . Multiple nutrient stimulation enhances enteroendocrine cell responses in human and mouse colon . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 29 , 20 - 21 .
McGuire C, Boundouki G, Hockley JR, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J et al. ( 2016 ) . Ex vivo study of human visceral nociceptors . GUT Article 27654583 , 1 - 11 .
Peiris M, Aziz H, Hao Z, Mumphrey M, Berthoud H-R, Blackshaw LA ( 2016 ) . 671 Molecular And Cellular Alterations in Mouse Colonic Chemosensory Mechanisms After Roux-en-Y Gastric Bypass . Gastroenterology . vol. 150 , s137 - s138 .
Aktar R, Peiris M, Tough IR, Eaton S, Kritas S, Kentish S, Mohammed S, Delalande JM et al. ( 2016 ) . Sa1688 Multiple Functional Roles for the Extracellular Matrix Glycoprotein Tenascin X . Gastroenterology . vol. 150 ,
de Jong PR, Takahashi N, Peiris M, Bertin S, Lee J, Gareau MG, Paniagua A, Harris AR et al. ( 2015 ) . TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP . Mucosal Immunol vol. 8 , ( 3 ) 491 - 504 .
Symonds EL, Peiris M, Page AJ, Chia B, Dogra H, Masding A, Galanakis V, Atiba M et al. ( 2015 ) . Mechanisms of activation of mouse and human enteroendocrine cells by nutrients . Gut vol. 64 , ( 4 ) 618 - 626 .
Woodland P, Aktar R, Mthunzi E, Lee C, Peiris M, Preston SL, Blackshaw LA, Sifrim D ( 2015 ) . Distinct afferent innervation patterns within the human proximal and distal esophageal mucosa . AJP Gastrointestinal and Liver Physiology vol. 308 , ( 6 ) g525 - g531 .
Peiris M, Dogra H, Araujo EJDA, Stagg AJ, Blackshaw A ( 2015 ) . CD11c Positive Dendritic Cells Express the Ion Channel TRPM8 in Human Colon, Which Regulates Immune Responses . GASTROENTEROLOGY . vol. 148 , S693 - S694 .
Reed DE, Broadhead A, Bulmer DC, Peiris M, Blackshaw A ( 2015 ) . Nutrient-Neural Signaling in the Proximal Colon . GASTROENTEROLOGY . vol. 148 , S385 - S385 .
Woodland P, Lee C-Y, Aktar R, Mthunzi E, Peiris M, Preston SL, Blackshaw A, Sifri D ( 2014 ) . 13 Enhanced Perception of Proximal Gastro-Esophageal Reflux in Patients With GERD: Impaired Mucosal Integrity or Distinct Sensory Innervation? . Gastroenterology vol. 146 , ( 5 )
Broadhead A, Mcguire C, Reed D, Peiris M, Knowles CH, Kurtz CB, Silos-Santiago A, Bulmer D et al. ( 2014 ) . Activation of guanylate cyclase C inhibits human and mouse intestinal afferent mechanosensitivity but not chemosensitivity . NEUROGASTROENTEROLOGY AND MOTILITY vol. 26 , 32 - 32 .
Broadhead A, Reed DE, Peiris M, Bulmer DC, Blackshaw A ( 2014 ) . Afferent Activation in the Proximal Colon by Enteroendocrine Mediators and Nutrients . GASTROENTEROLOGY . vol. 146 , S366 - S366 .
Peiris M, Dogra H, Robinow AD, Page AJ, Young RL, Blackshaw A ( 2014 ) . Amino Acid and Fatty Acid Sensing Mechanisms in the Human Colon . GASTROENTEROLOGY . vol. 146 , S492 - S492 .
Woodland P, Lee C-Y, Aktar R, Mthunzi E, Peiris M, Preston SL, Blackshaw A, Sifrim D ( 2014 ) . Enhanced Perception of Proximal Gastro-Esophageal Reflux in Patients With GERD: Impaired Mucosal Integrity or Distinct Sensory Innervation? . GASTROENTEROLOGY . vol. 146 , S4 - S5 .
Woodland P, Aktar R, Lee C-Y, Mthunzi E, Peiris M, Preston SL, Blackshaw A, Sifrim D ( 2014 ) . Long-Lasting "In Vitro" Esophageal Mucosal Protection With Alginates: A Potential for Topical Mucosal Therapy in Gastroesophageal Reflux Disease . GASTROENTEROLOGY . vol. 146 , S757 - S758 .
Dogra H, Peiris M, Robinow AD, Blackshaw A, Sanderson IR ( 2014 ) . Nutrient-Induced Reduction of IL-8 Release in Paediatric Human Ascending Colon . GASTROENTEROLOGY . vol. 146 , S783 - S783 .
Peiris M, Reed DE, Broadhead A, Knowles CH, Bulmer DC, Blackshaw A ( 2014 ) . Role of Kv7 Potassium Channels in Excitation of Human Colonic Afferents . GASTROENTEROLOGY . vol. 146 , S722 - S722 .
Farmer AD, Peiris M, Aziz Q ( 2013 ) . Gut Hypersensitivity Related Symptoms . Irritable Bowel Syndrome , Wiley
Galanakis V, Peiris M, Blacksaw AL ( 2013 ) . 'NUTRIENT SENSING IN THE HUMAN GUT: INVESTIGATION OF THE CO-LOCALIZATION RATE BETWEEN CASR, T1R1 AND GPR43 RECEPTORS WITH SATIETY PEPTIDES IN THE HUMAN ANTRUM, TERMINAL ILEUM AND ASCENDING COLON' . GUT . vol. 62 , A103 - A103 .
McGuire C, Harrington AM, Hubball A, McPhail H, Peiris M, Bulmer DC, Knowles CH, Blackshaw LA ( 2013 ) . Anatomical Sensory Nerve Markers in Human Gut . GASTROENTEROLOGY . vol. 144 , S56 - S56 .
Aktar R, Fikree A, Peiris M, Aziz Q, Blackshaw LA ( 2013 ) . Extracellular Matrix Protein Tenascin-X in Nerve-Gut Interactions . GASTROENTEROLOGY . vol. 144 , S554 - S554 .
McGuire C, Boundouki G, Peiris M, Blackshaw LA, Knowles CH, Bulmer DC ( 2013 ) . Identification of a Distinct Population of Human Visceral Nociceptors . GASTROENTEROLOGY . vol. 144 , S670 - S670 .
Peiris M, Masding A, Galanakis V, Bulmer DC, Knowles CH, Blackshaw LA ( 2013 ) . Specific Pathways of Nutrient Activation in Human and Mouse Enteroendocrine Eells . GASTROENTEROLOGY . vol. 144 , S374 - S374 .
Page AJ, Symonds E, Peiris M, Blackshaw LA, Young RL ( 2012 ) . Peripheral neural targets in obesity . Br J Pharmacol vol. 166 , ( 5 ) 1537 - 1558 .
Peiris M, Atiba MA, Hubball A, Bulmer DC, Knowles CH, Blackshaw LA ( 2012 ) . 1104 Molecular Aspects of Nutrient Sensing in the Human Gastrointestinal Tract . Gastroenterology vol. 142 , ( 5 ) s - 199 .
Peiris M, Masding A, Bulmer D, Knowles C, Blackshaw LA ( 2012 ) . Functional characterisation of human and mouse proximal colon as a site of nutrient sensing . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 24 , 151 - 151 .
Mcguire C, Boundouki G, Hockley J, Peiris M, Blackshaw A, Knowles C, Bulmer D ( 2012 ) . Mechanical and chemical stimulation of human visceral afferents . NEUROGASTROENTEROLOGY AND MOTILITY vol. 24 , 74 - 74 .
Peiris M, Atiba MA, Hubball A, Bulmer DC, Knowles CH, Blackshaw LA ( 2012 ) . Molecular Aspects of Nutrient Sensing in the Human Gastrointestinal Tract . GASTROENTEROLOGY . vol. 142 , S199 - S199 .
Chua YC, Hubball A, Peiris M, Ng KS, Hughes SF, Chinaleong J, Preston S, Patel B et al. ( 2011 ) . OESOPHAGEAL EPITHELIAL ASIC3 IS ASSOCIATED WITH INCREASE IN SEVERITY OF SYMPTOMS IN PATIENTS WITH GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) . GUT . vol. 60 , A171 - A171 .
Peiris M, Bulmer DC, Baker MD, Boundouki G, Sinha S, Hobson A, Lee K, Aziz Q et al. ( 2011 ) . Human visceral afferent recordings: preliminary report . Gut vol. 60 , ( 2 ) 204 - 208 .
Boundouki G, Peiris M, Baker MD, Bulmer DC, Aziz Q, Hobson A, Sinha S, Lee K et al. ( 2010 ) . A novel in vitro model of visceral pain using the human appendix . BRITISH JOURNAL OF SURGERY vol. 97 , 31 - 32 .
Vetter I, Cheng W, Peiris M, Wyse BD, Roberts-Thomson SJ, Zheng J, Monteith GR, Cabot PJ ( 2008 ) . Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization . J Biol Chem vol. 283 , ( 28 ) 19540 - 19550 .
Peiris M, Monteith GR, Roberts-Thomson SJ, Cabot PJ ( 2007 ) . A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapies . J Neurosci Methods vol. 163 , ( 2 ) 245 - 254 .
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