Publications: Prof Costantino Pitzalis

Hanlon MM, Smith CM, Canavan M, Neto NGB, Song Q, Lewis MJ, O'Rourke AM, Tynan O et al. ( 2024 ) . Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset . Science Advances vol. 10 , ( 39 )

Thomas BL, Montero‐Melendez T, Oggero S, Kaneva MK, Chambers D, Pinto AL, Nerviani A, Lucchesi D et al. ( 2024 ) . Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis . Arthritis & Rheumatology

Zack SR, Alzoubi O, Satoeya N, Singh KP, Deen S, Nijim W, Lewis MJ, Pitzalis C et al. ( 2024 ) . Another Notch in the Belt of Rheumatoid Arthritis . Arthritis & Rheumatology vol. 76 , ( 10 ) 1475 - 1487 .

Ruscitti P, Allanore Y, Baldini C, Barilaro G, Bartoloni Bocci E, Bearzi P, Bellis E, Berardicurti O et al. ( 2024 ) . Tailoring the treatment of inflammatory rheumatic diseases by a better stratification and characterization of the clinical patient heterogeneity. Findings from a systematic literature review and experts' consensus . Autoimmunity Reviews vol. 23 , ( 7-8 )

Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L et al. ( 2024 ) . Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues . EMBO Reports vol. 25 , ( 9 ) 3842 - 3869 .

Çubuk C, Lau R, Cutillas P, Rajeeve V, John CR, Surace AEA, Hands R, Fossati-Jimack L et al. ( 2024 ) . Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes . Arthritis Research & Therapy vol. 26 , ( 1 )

Dunlap G, Wagner A, Meednu N, Wang R, Zhang F, Ekabe JC, Jonsson AH, Wei K et al. ( 2024 ) . Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium . Nature Communications vol. 15 , ( 1 )

Stadler M, Rivellese F, Plant D, Hyrich K, Isaacs J, Morgan A, Wilson AG, Verstappen S et al. ( 2024 ) . AB0757 TREATMENT RESPONSE CRITERIA FOR THE TWO-COMPONENT DISEASE ACTIVITY SCORE . Conference: Scientific Abstracts1670.2 - 161670 .

Pontarini E, Sciacca E, Cavallaro G, Galbraith D, Pulvirenti A, Hao LY, Sivils K, Lewis M et al. ( 2024 ) . AB0809 USER-FRIENDLY TOOL FOR EXPLORING RNA-SEQUENCE AND BIOMARKER DISCOVERY IN SJOGREN’S DISEASE: ANALYSE THE TWO BIGGEST DATASETS OF BLOOD AND SALIVARY GLAND RNA-SEQUENCING DATA USING R SHINY APPS . Conference: Scientific Abstracts1699.2 - 161699 .

Lau R, Cubuk C, Rajeeve V, Cutillas P, Hands R, Fossati-Jimack L, Surace A, Lewis M et al. ( 2024 ) . OP0218 SYNOVIAL PHOSPHOPROTEOME ANALYSIS OF LATE-STAGE RHEUMATOID ARTHRITIS PATIENTS (R4RA TRIAL) IDENTIFIES SIGNALLING PATHWAYS ASSOCIATED WITH PATHOTYPE AND RESPONSE TO RITUXIMAB AND TOCILIZUMAB . Conference: Scientific Abstracts12 - 12 .

Wang S, Nair N, Cubuk C, Yap CF, Lau R, Giorli G, Fossati-Jimack L, Plant D et al. ( 2024 ) . OP0224 INTEGRATION OF DNA METHYLATION INTO MULTI-OMIC ANALYSIS OF SYNOVIAL BIOPSIES FROM THE STRAP RANDOMIZED CLINICAL TRIAL IDENTIFIES PREDICTORS OF RESPONSE TO ANTI-TNF THERAPY IN RHEUMATOID ARTHRITIS . Conference: Scientific Abstracts13.1 - 1313 .

Surace A, Overend L, Sciacca E, Fossati-Jimack L, Jaworska E, Pontarini E, Bashford-Rogers RJM, Pitzalis C et al. ( 2024 ) . OP0242 SYNOVIAL TISSUE AND BLOOD DEEP B/T CELL PHENOTYPING EXPLAINS RESPONSE MECHANISMS TO RITUXIMAB IN RHEUMATOID ARTHRITIS IN R4RA . Conference: Scientific Abstracts13.2 - 1314 .

Pontarini E, Rizzo MT, Liefers SC, Cavallaro G, Van der Vegt B, Colafrancesco S, Zabotti A, Quartuccio L et al. ( 2024 ) . POS0265 ESTABLISHING CONSISTENCY IN THE DIGITAL IMAGING ANALYSIS OF HISTOLOGICAL PARAMETERS IN SJOGREN’S DISEASE . Conference: Scientific Abstracts282.2 - 28283 .

Iaquinta FS, Sciacca E, Abatecola F, Fossati-Jimack L, Pitzalis C, Rivellese F ( 2024 ) . POS0351 A POST-HOC ANALYSIS OF THE BIOPSY-DRIVEN, MULTICENTRE, RANDOMISED R4RA CLINICAL TRIAL REVEALS AN INNATE IMMUNE SIGNATURE IN MULTI-DRUG RESISTANT RHEUMATOID ARTHRITIS PATIENTS WITH A LYMPHO-MYELOID PATHOTYPE . Conference: Scientific Abstracts302.2 - 30303 .

Colafrancesco S, Simoncelli E, Pontarini E, Cavallaro G, Lucchesi D, Marino A, Buoncuore G, Barbati C et al. ( 2024 ) . POS0997 INFLAMMATION IN SJӦGREN DISEASE INDUCES SALIVARY GLAND EPITHELIAL CELLS (SGECS) METABOLIC REPROGRAMMING: FOCUS ON GLYCOLYSIS AND ITS REGULATION OF EPITHELIAL CELL ACTIVATION . Conference: Scientific Abstracts862 - 863 .

Weinand K, Sakaue S, Nathan A, Jonsson AH, Zhang F, Watts GFM, Al Suqri M, Zhu Z et al. ( 2024 ) . The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis . Nature Communications vol. 15 , ( 1 )

Corsiero E, Caliste M, Jagemann L, Fossati-Jimack L, Goldmann K, Cubuk C, Ghirardi GM, Prediletto E et al. ( 2024 ) . Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response . Journal of Clinical Investigation vol. 134 , ( 12 )

Perera J, Delrosso CA, Nerviani A, Pitzalis C ( 2024 ) . Clinical Phenotypes, Serological Biomarkers, and Synovial Features Defining Seropositive and Seronegative Rheumatoid Arthritis: A Literature Review . Cells vol. 13 , ( 9 )

Bai Z, Bartelo N, Aslam M, Murphy EA, Hale CR, Blachere NE, Parveen S, Spolaore E et al. ( 2024 ) . Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis . Science Translational Medicine vol. 16 , ( 742 )

Sakaue S, Weinand K, Isaac S, Dey KK, Jagadeesh K, Kanai M, Watts GFM, Zhu Z et al. ( 2024 ) . Tissue-specific enhancer–gene maps from multimodal single-cell data identify causal disease alleles . Nature Genetics vol. 56 , ( 4 ) 615 - 626 .

Nerviani A, Boutet M-A, Ghirardi GM, Goldmann K, Sciacca E, Rivellese F, Pontarini E, Prediletto E et al. ( 2024 ) . Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis . Nature Communications vol. 15 , ( 1 )

Pontarini E, Sciacca E, Chowdhury F, Grigoriadou S, Rivellese F, Murray‐Brown WJ, Lucchesi D, Fossati‐Jimack L et al. ( 2024 ) . Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) to B Cell–Targeted Therapy in the Trial of Anti–B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS) . Arthritis & Rheumatology vol. 76 , ( 5 ) 763 - 776 .

Weisenfeld D, Zhang F, Donlin L, Jonsson AH, Apruzzese W, Campbell D, Network AMPPRS, Rao DA et al. ( 2024 ) . Associations Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Types and States . Arthritis & Rheumatology vol. 76 , ( 3 ) 356 - 362 .

Meyer A, Zack SR, Nijim W, Burgos A, Patel V, Zanotti B, Volin MV, Amin MA et al. ( 2023 ) . Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis . Cellular & Molecular Immunology vol. 21 , ( 1 ) 33 - 46 .

Pitzalis C ( 2023 ) . Advances in Targeted Therapies (ATT) What's cooking in the academic's kitchen? 3TR (IMI) . Seminars in Arthritis and Rheumatism vol. 64 ,

Boutet M-A, Nerviani A, Fossati-Jimack L, Hands-Greenwood R, Ahmed M, Rivellese F, Pitzalis C ( 2023 ) . Comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features . Osteoarthritis and Cartilage vol. 32 , ( 2 ) 166 - 176 .

Goldmann K, Spiliopoulou A, Iakovliev A, Plant D, Nair N, Cubuk C, Consortium TM, McKeigue P et al. ( 2023 ) . Expression quantitative trait loci analysis in rheumatoid arthritis identifies tissue specific variants associated with severity and outcome . Annals of the Rheumatic Diseases vol. 83 , ( 3 ) 288 - 299 .

Iaquinta FS, Rivellese F, Pitzalis C ( 2023 ) . Synovial biopsies for molecular definition of rheumatoid arthritis and treatment response phenotyping: where can we improve? . Expert Review of Molecular Diagnostics vol. 23 , ( 12 ) 1071 - 1076 .

Zhang F, Jonsson AH, Nathan A, Millard N, Curtis M, Xiao Q, Gutierrez-Arcelus M, Apruzzese W et al. ( 2023 ) . Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes . Nature vol. 623 , ( 7987 ) 616 - 624 .

Rivellese F, Nerviani A, Giorli G, Warren L, Jaworska E, Bombardieri M, Lewis MJ, Humby F et al. ( 2023 ) . Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials . The Lancet Rheumatology vol. 5 , ( 11 ) e648 - e659 .

MacBrayne A, Curzon P, Soyel H, Marsh W, Fenton N, Pitzalis C, Humby F ( 2023 ) . Attitudes to technology supported rheumatoid arthritis care: investigating patient and clinician perceived opportunities and barriers . Rheumatology Advances in Practice

Zack SR, Meyer A, Zanotti B, Volin MV, Deen S, Satoeya N, Sweiss N, Lewis MJ et al. ( 2023 ) . Notch ligands are biomarkers of anti-TNF response in RA patients . Angiogenesis vol. 27 , ( 2 ) 273 - 283 .

Wang SS, Lewis MJ, Pitzalis C ( 2023 ) . DNA Methylation Signatures of Response to Conventional Synthetic and Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis . Biomedicines vol. 11 , ( 7 )

Kugler M, Dellinger M, Kartnig F, Müller L, Preglej T, Heinz LX, Simader E, Göschl L et al. ( 2023 ) . Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis . Annals of the Rheumatic Diseases vol. 82 , ( 9 ) 1142 - 1152 .

Vigorito E, Barton A, Pitzalis C, Lewis MJ, Wallace C ( 2023 ) . BBmix: a Bayesian beta-binomial mixture model for accurate genotyping from RNA-sequencing . Bioinformatics vol. 39 , ( 7 )

Khmelevskaya A, Houtman M, Buerki K, Pauli C, Rivellese F, Prediletto E, Pitzalis C, Distler O et al. ( 2023 ) . AB0062 ABUNDANCE AND ACTIVATION OF MEMORY B-CELLS CHARACTERIZE SYNOVITIS IN RHEUMATOID ARTHRITIS PATIENTS WITH EARLY TREATMENT RESPONSE . 1210.1 - 121210 .

Ghirardi GM, Nerviani A, Fossati-Jimack L, Pontarini E, Italiani P, Pratesi F, Abdelmoaty S, Högerkorp C et al. ( 2023 ) . AB0067 MODE OF ACTION AND TARGET INVESTIGATION OF THE NEW ANTI-RHEUMATIC DRUG RABEXIMOD . 1212.2 - 121213 .

Rivellese F, Currado D, Giorli G, Prediletto E, Nerviani A, Khmelevskaya A, Micheroli R, Ospelt C et al. ( 2023 ) . AB0340 MULTI-DRUG RESISTANT RA IS ASSOCIATED WITH HIGHER BASELINE DISEASE ACTIVITY, MULTI-MORBIDITY, AND LOWER QUALITY OF LIFE: ANALYSES FROM THE R4RA BIOPSY-DRIVEN CLINICAL TRIAL . 1353 - 1354 .

Pontarini E, Lucchesi D, Goldmann K, Lewis M, Song Q, Thomas E, Hao LY, Sivils K et al. ( 2023 ) . POS0292 TRANSCRIPTOMIC PROFILING OF SJOGREN’S SALIVARY GLANDS IDENTIFIES FOLLICULAR AND EXTRA-FOLLICULAR GENE SIGNATURES ASSOCIATED WITH RHEUMATOID FACTOR SEROPOSITIVITY . 388.2 - 38388 .

Ruscitti P, Currado D, Rivellese F, Vomero M, Navarini L, Cipriani P, Pitzalis C, Giacomelli R ( 2023 ) . POS1020 A DIMINISHED EXPRESSION OF THE UBIQUITIN-PROTEASOME SYSTEM IN PATIENTS WITH RHEUMATOID ARTHRITIS AND DIABETES IS LINKED TO IL-1 PATHWAY HYPER-ACTIVITY . 826.2 - 82827 .

Curzon P, Macbrayne A, Humby F, Marsh D, Soyel H, Fenton N, Pitzalis C ( 2023 ) . Attitudes to Technology supported Rheumatoid Arthritis care Questionnaire study: Barriers to People with RA & their clinicians using Technology in the care pathway . Oxford Rheumatology . Conference: British Society for Rheumatology Annual COnference 2023 ( Manchester Central ) from: 24/03/2023 to: 26/04/2023 ,

Curzon P, Macbrayne A, Soyel H, Marsh D, Fenton N, Pitzalis C, Humby F ( 2023 ) . Attitudes to Technology supported Rheumatoid Arthritis care, questionnaire study: Opportunities for technology to improve RA care . Oxford Rheumatology . Conference: British Society for Rheumatology Annual Conference, 2023 ( Manchester Central ) from: 24/04/2023 to: 26/04/2023 ,

Curzon P, Macbrayne A, Soyel H, Marsh D, Fenton N, Pitzalis C, Humby F ( 2023 ) . Attitudes to Technology supported Rheumatoid Arthritis care: Opportunities & Barriers for technology in RA -Key themes from Qualitative arm of Mixed-Methods Study . Oxford Rheumatology . Conference: British SOciety for Rheumatology Annual COnference, 2023 ( Manchester Central ) from: 24/04/2023 to: 26/04/2023 ,

Sciacca E, Alaimo S, Silluzio G, Ferro A, Latora V, Pitzalis C, Pulvirenti A, Lewis MJ ( 2023 ) . DEGGs: an R package with shiny app for the identification of differentially expressed gene–gene interactions in high-throughput sequencing data . Bioinformatics vol. 39 , ( 4 )

Lewis MJ, Spiliopoulou A, Goldmann K, Pitzalis C, McKeigue P, Barnes MR ( 2023 ) . nestedcv: an R package for fast implementation of nested cross-validation with embedded feature selection designed for transcriptomics and high-dimensional data . Bioinformatics Advances vol. 3 , ( 1 )

Mauro D, Manou-Stathopoulou S, Rivellese F, Sciacca E, Goldmann K, Tsang V, Lucey-Clayton I, Pagani S et al. ( 2023 ) . UBE2L3 regulates TLR7-induced B cell autoreactivity in Systemic Lupus Erythematosus . Journal of Autoimmunity vol. 136 ,

Meyer A, Sienes RE, Nijim W, Zanotti B, Umar S, Volin MV, Van Raemdonck K, Lewis M et al. ( 2023 ) . Syntenin-1-mediated arthritogenicity is advanced by reprogramming RA metabolic macrophages and Th1 cells . Annals of the Rheumatic Diseases vol. 82 , ( 4 ) 483 - 495 .

Aly NAR, Rizk S, Enein AA, Desoukey NE, Zawam H, Ahmed M, Shikh MEE, Pitzalis C ( 2022 ) . The role of lymphoid tissue SPARC in the pathogenesis and response to treatment of multiple myeloma . Frontiers in Oncology vol. 12 ,

Lewis MJ, Pitzalis C ( 2022 ) . Progress continues in prediction of the response to treatment of RA . Nature Reviews Rheumatology vol. 19 , ( 2 ) 68 - 69 .

Caxaria S, Kouvatsos N, Eldridge SE, Alvarez-Fallas M, Thorup A-S, Cici D, Barawi A, Arshed A et al. ( 2022 ) . Disease modification and symptom relief in osteoarthritis using a mutated GCP-2/CXCL6 chemokine . EMBO Molecular Medicine

Shikh MEME, Sayed RE, Aly NAR, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis MJ et al. ( 2022 ) . Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis . Frontiers in Medicine vol. 9 ,

Rivellese F, Pitzalis C ( 2022 ) . Introduction to the special issue: Cellular and molecular diversity in rheumatic autoimmune diseases . Seminars in Immunology vol. 58 ,

Flak MB, Colas RA, Muñoz-Atienza E, Curtis MA, Dalli J, Pitzalis C ( 2022 ) . Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis . JCI Insight vol. 7 , ( 20 )

Wang J, Conlon D, Rivellese F, Nerviani A, Lewis MJ, Housley W, Levesque MC, Cao X et al. ( 2022 ) . Synovial Inflammatory Pathways Characterize Anti‐TNF–Responsive Rheumatoid Arthritis Patients . Arthritis & Rheumatology vol. 74 , ( 12 ) 1916 - 1927 .

Humby F, Durez P, Buch MH, Lewis MJ, Bombardieri M, John C, Rizvi H, Warren L et al. ( 2022 ) . Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients:the R4-RA RCT . Efficacy and Mechanism Evaluation vol. 9 , ( 7 ) 1 - 58 .

Carlotti E, Murray-Brown W, Blighe K, Caliste M, Astorri E, Sutcliffe N, Tappuni AR, Pitzalis C et al. ( 2022 ) . High-throughput sequencing of IgH gene in minor salivary glands from Sjögren's syndrome patients reveals dynamic B cell recirculation between ectopic lymphoid structures . Clinical and Experimental Rheumatology vol. 40 , ( 12 ) 2363 - 2372 .

Sciacca E, Surace AEA, Alaimo S, Pulvirenti A, Rivellese F, Goldmann K, Ferro A, Latora V et al. ( 2022 ) . Network analysis of synovial RNA sequencing identifies gene-gene interactions predictive of response in rheumatoid arthritis . Arthritis Research & Therapy vol. 24 , ( 1 )

Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CM, Millar B, Maney NJ, Anderson AE et al. ( 2022 ) . Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming . Annals of the Rheumatic Diseases vol. 81 , ( 9 ) 1214 - 1223 .

Banda NK, Deane KD, Bemis EA, Strickland C, Seifert J, Jordan K, Goldman K, Morgan BP et al. ( 2022 ) . Analysis of Complement Gene Expression, Clinical Associations, and Biodistribution of Complement Proteins in the Synovium of Early Rheumatoid Arthritis Patients Reveals Unique Pathophysiologic Features . The Journal of Immunology vol. 208 , ( 11 ) 2482 - 2496 .

Papandrikopoulou A, Burmester GR, Fang F, Kivitz A, Njenga M, Pano A, Pitzalis C, Samant M et al. ( 2022 ) . AB0379 DOSE-DEPENDENT SUPPRESSION OF T CELL-DEPENDENT ANTIBODY RESPONSE IN HEALTHY VOLUNTEERS BY KPL-404, AN ANTI-CD40 MONOCLONAL ANTIBODY, SUPPORTS CHRONIC DOSING STUDY IN PATIENTS WITH RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 81 , 1316.2 - 131317 .

Surace A, Sciacca E, Goldmann K, Rivellese F, Cubuk C, Giorli G, Fossati-Jimack L, Ahmed M et al. ( 2022 ) . OP0077 SYNOVIAL RNA-SEQ ANALYSIS OF THE R4RA TRIAL IDENTIFIES SIGNATURES OF TREATMENT RESISTANCE AND REFRACTORY STATE IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 52.2 - 5253 .

Rivellese F, Cubuk C, Surace A, Goldmann K, Sciacca E, Giorli G, Nerviani A, Fossati-Jimack L et al. ( 2022 ) . OP0085 CELL LINEAGE-SPECIFIC TRANSCRIPT DECONVOLUTION OF SYNOVIAL BIOPSIES FROM THE R4RA TRIAL IDENTIFIES CELL POPULATIONS ASSOCIATED WITH RESPONSE TO RITUXIMAB AND TOCILIZUMAB . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 56.2 - 5657 .

Goldmann K, Vigorito E, Wallace C, Barnes M, Barton A, Pitzalis C, Lewis M ( 2022 ) . OP0109 EXPRESSION QUANTITATIVE TRAIT LOCI IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 81 , 71 - 72 .

Prediletto E, Cubuk C, Pontarini E, Rivellese F, Nerviani A, Lucchesi D, Caliste M, Corsiero E et al. ( 2022 ) . POS0138 RHEUMATOID SYNOVIAL FIBROBLASTS DISPLAY IMPRINTED MEMORY OF THEIR SYNOVIAL ENDOTYPE WHICH CAN BE PLASTICALLY MODULATED BY B-CELLS CROSSTALK . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 296.1 - 29296 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Murray-Brown W, Rivellese F, Lucchesi D, Goldmann K et al. ( 2022 ) . POS0145 CLINICAL RESPONSE TO RITUXIMAB IS ASSOCIATED WITH PREVENTION OF B-CELL DRIVEN SALIVARY GLAND INFLAMMATION AND EPITHELIAL RESTORATION AS REVEALED BY MOLECULAR PATHOLOGY: RESULTS FROM THE TRACTISS TRIAL IN PRIMARY SJOGREN’S SYNDROME . Annals of the Rheumatic Diseases . vol. 81 , 299.2 - 29300 .

Corsiero E, Caliste M, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M ( 2022 ) . POS0399 CHARACTERIZATION OF HSP60, A STROMAL-DERIVED AUTOANTIGEN, RECOGNIZED BY RA SYNOVIAL RECOMBINANT MONOCLONAL ANTIBODIES . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 456.1 - 45456 .

Elshikh M, El Sayed R, Aly N, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis M et al. ( 2022 ) . POS0431 PDGF-BB, TNF-α, AND LT-β REGULATE FOLLICULAR DENDRITIC CELL DEVELOPMENT IN THE RHEUMATOID SYNOVIUM . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 470.1 - 47470 .

Caliste M, Prediletto E, Corsiero E, Jagemann L, Pitzalis C, Bombardieri M ( 2022 ) . POS0439 STROMAL B-CELL CROSSTALK PROMOTES THE ESTABLISHMENT OF SYNOVIAL B CELL NICHES THROUGH THE SELECTION, ACTIVATION OF NATURALLY OCCURRING EBV+ B CELLS . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 474.2 - 47475 .

Nerviani A, Boutet MA, Ghirardi GM, Goldmann K, Sciacca E, Rivellese F, Pontarini E, Caliste M et al. ( 2022 ) . POS0441 IN-DEPTH ANALYSIS OF Axl AND MerTK EXPRESSION PATTERNS AND REGULATION BY BIOLOGIC TREATMENTS IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 81 , 475.2 - 47476 .

Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A et al. ( 2022 ) . Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial . Nature Medicine vol. 28 , ( 6 ) 1256 - 1268 .

( 2022 ) . RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients . Scientific Data vol. 9 , ( 1 )

Banda NK, Deane KD, Seifert J, Strickland C, Bemis E, Jordan K, Goldmann K, Morgan BP et al. ( 2022 ) . A Snap Shot of Complement Gene Expression and Presence of Complement Proteins in Synovial Biopsies from Early Rheumatoid Arthritis Patients . The Journal of Immunology vol. 208 , ( 1_Supplement ) 108.03 - 108.03 .

Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S et al. ( 2022 ) . Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression . Cell Reports vol. 39 , ( 5 )

Pistorius K, Ly L, Souza PR, Gomez EA, Koenis DS, Rodriguez AR, Foster J, Sosabowski J et al. ( 2022 ) . MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis . EBioMedicine vol. 79 ,

Thorup A-S, Wilson J, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G et al. ( 2022 ) . BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS, IN PART BY MODULATING YAP SIGNALLING . Osteoarthritis and Cartilage vol. 30 ,

Carlucci PM, Li J, Fava A, Deonaraine KK, Wofsy D, James JA, Putterman C, Diamond B et al. ( 2022 ) . High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership . Rheumatology vol. 61 , ( 11 ) 4335 - 4343 .

Najm A, Costantino F, Alivernini S, Alunno A, Bianchi E, Bignall J, Boyce B, Cañete JD et al. ( 2022 ) . EULAR points to consider for minimal reporting requirements in synovial tissue research in rheumatology . Annals of the Rheumatic Diseases vol. 81 , ( 12 ) 1640 - 1646 .

Micheroli R, Elhai M, Edalat S, Frank-Bertoncelj M, Bürki K, Ciurea A, MacDonald L, Kurowska-Stolarska M et al. ( 2022 ) . Role of synovial fibroblast subsets across synovial pathotypes in rheumatoid arthritis: a deconvolution analysis . RMD Open vol. 8 , ( 1 )

Iakovliev A, Ling SF, Colombo M, Plant D, Lewis M, Pitzalis C, Barton A, McKeigue P et al. ( 2022 ) . Association of Genetic Loci for Human Plasma Proteins with Response to Treatment in People with Rheumatoid Arthritis . GENETIC EPIDEMIOLOGY . vol. 46 , 501 - 502 .

Rivellese F, Pitzalis C ( 2022 ) . Cellular and molecular diversity in Rheumatoid Arthritis . Seminars in Immunology

Banda N, Deane K, Seifert J, Strickland C, Bemis E, Jordan K, Goldman K, Morgan BP et al. ( 2022 ) . Complement gene expression and biodistribution of complement proteins in the synovium from early rheumatoid arthritis patients . MOLECULAR IMMUNOLOGY . vol. 141 , 156 - 156 .

Pupim L, Burmester G, Fang F, Kivitz A, Njenga M, Pitzalis C, Chatfield J, Papandrikopoulou A et al. ( 2022 ) . Dose-dependent Suppression of T Cell-Dependent Antibody Response in Healthy Volunteers by KPL-404, an Anti-CD40 Monoclonal Antibody, Supports Phase 2 Study in Patients with Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 609 - 610 .

Pistorius K, Souza PR, Gomez EA, Koenis DS, Rodriguez AR, Foster J, Sosabowski J, Hopkinson M et al. ( 2022 ) . MCTR3 reprogramming arthritic monocytes to exert pro-resolving and tissue-protective functions in inflammatory arthritis . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 103 , A5 - A6 .

Rivellese F, Pontarini E, Cubuk C, Nerviani A, Fossati-Jimack L, Surace A, Sciacca E, Goldmann K et al. ( 2022 ) . Module Signatures of Synovial Single-cell States Identify Disease Phenotypes in Early Treatment-naive Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 3345 - 3347 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Emery P, Ng WF, Sutcliffe N, Rivellese F et al. ( 2022 ) . RITUXIMAB PREVENTS WORSENING OF B-CELL DRIVEN SALIVARY GLAND INFLAMMATION AND EXCRETORY FUNCTION IN PRIMARY SJOGREN'S SYNDROME: RESULTS FROM THE TRACTISS TRIAL . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 40 , 91 - 92 .

Prediletto E, Cubuk C, Pontarini E, Rivellese F, Nerviani A, Lucchesi D, Caliste M, Corsiero E et al. ( 2022 ) . Rheumatoid Synovial Fibroblasts Display Imprinted Memory of Their Synovial Endotype Which Can Be Plastically Modulated by B-cells Crosstalk . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 1242 - 1244 .

Dunlap G, Wagner A, Meednu N, Jonsson A, Zhang F, Wei K, Utz P, Robinson W et al. ( 2022 ) . Single-Cell Characterization of the TCR Repertoire Across Tissue and Blood in Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 3442 - 3444 .

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Pitzalis C, Hands R, Venuturupalli S, Ben-Artzi A, Ruderman E, Perlman H, Mandelin A, Leach M et al. ( 2022 ) . Tc99m Tilmanocept Imaging Can Differentiate the Fibroid Pathotype of Rheumatoid Arthritis from Non-Fibroid Pathotypes in Patients . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 3906 - 3907 .

Dejaco C, Machado PM, Carubbi F, Bosch P, Terslev L, Tamborrini G, Sconfienza LM, Scirè CA et al. ( 2021 ) . EULAR points to consider for the use of imaging to guide interventional procedures in patients with rheumatic and musculoskeletal diseases (RMDs) . Annals of the Rheumatic Diseases vol. 81 , ( 6 ) 760 - 767 .

Iqbal AJ, Krautter F, Blacksell IA, Wright RD, Austin‐Williams SN, Voisin M, Hussain MT, Law HL et al. ( 2021 ) . Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner . The FASEB Journal vol. 36 , ( 1 )

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Coleby R, Lucchesi D, Pontarini E, Pitzalis C, Bombardieri M ( 2021 ) . Stepwise changes in the murine salivary gland immune response during virally-induced ectopic lymphoid structure formation . Clinical and Experimental Rheumatology vol. 39 Suppl 133 , ( 6 ) 39 - 48 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Goldmann K, Fossati-Jimack L et al. ( 2021 ) . OP0136 RITUXIMAB PREVENTS THE PROGRESSION OF B-CELL DRIVEN INFLAMMATORY INFILTRATE IN THE MINOR SALIVARY GLANDS OF PRIMARY SJOGREN’S SYNDROME BY DOWNREGULATING IMMUNOLOGICAL PATHWAYS KEY IN ECTOPIC GERMINAL CENTRE ORGANIZATION: RESULTS FROM THE TRACTISS TRIAL . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 79 - 80 .

Pontarini E, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Fossati-Jimack L, Coleby R, Chowdhury F et al. ( 2021 ) . NKp30 Receptor Upregulation in Salivary Glands of Sjögren’s Syndrome Characterizes Ectopic Lymphoid Structures and Is Restricted by Rituximab Treatment . Frontiers in Immunology vol. 12 ,

Deonaraine KK, Carlucci PM, Fava A, Li J, Wofsy D, James JA, Putterman C, Diamond B et al. ( 2021 ) . Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network . Lupus Science & Medicine vol. 8 , ( 1 )

Serrano-Blesa E, Porter A, Lendrem DW, Pitzalis C, Barton A, Treumann A, Isaacs JD ( 2021 ) . Robust optimization of SWATH-MS workflow for human blood serum proteome analysis using a quality by design approach . Clinical Proteomics vol. 18 , ( 1 )

Silva‐Gomes R, Mapelli SN, Boutet M, Mattiola I, Sironi M, Grizzi F, Colombo F, Supino D et al. ( 2021 ) . Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditions . Journal of Leukocyte Biology vol. 111 , ( 4 ) 817 - 836 .

Boutet M-A, Nerviani A, Lliso-Ribera G, Leone R, Sironi M, Hands R, Rivellese F, Del Prete A et al. ( 2021 ) . Circulating and Synovial Pentraxin-3 (PTX3) Expression Levels Correlate With Rheumatoid Arthritis Severity and Tissue Infiltration Independently of Conventional Treatments Response . Frontiers in Immunology vol. 12 ,

Colombo F, Corsiero E, Lewis MJ, Pitzalis C ( 2021 ) . Generation of restriction endonucleases barcode map to trace SARS-CoV-2 origin and evolution . Scientific Reports vol. 11 , ( 1 )

Eldridge S, Barawi A, Wang H, Roelofs A, Kaneva M, Guan Z, Lydon H, Thomas B et al. ( 2021 ) . AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 1052.1 - 101052 .

Rivellese F, Pontarini E, Fossati-Jimack L, Moura RA, Romão VC, Fonseca JE, Nerviani A, Cubuk C et al. ( 2021 ) . OP0011 INTEGRATION OF FLOW AND DIGITAL CYTOMETRY IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS IDENTIFIES DISTINCT IMMUNOPHENOTYPES IN PERIPHERAL BLOOD AND DISEASE TISSUE . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 7.2 - 7.7 .

Thorup AS, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J et al. ( 2021 ) . OP0200 BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS . Annals of the Rheumatic Diseases vol. 80 , ( Suppl 1 ) 120.1 - 12121 .

Pagani S, Colombo F, Pitzalis C ( 2021 ) . POS0206 DESIGN AND CHARACTERISATION OF A THERAPEUTIC BISPECIFIC TANDEM scFv-Fc FUSION PROTEIN WITH ANTI-TNF AND SYNOVIUM-TARGETING SPECIFICITY FOR THE TREATMENT OF RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 80 , 319 - 320 .

Thomas B, Eldridge S, Nosrati B, Alvarez M, THORUP A-S, Nalesso G, Caxaria S, Barawi A et al. ( 2021 ) . WNT3A-loaded exosomes enable cartilage repair . Journal of Extracellular Vesicles

Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S et al. ( 2021 ) . Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression .

Fanelli G, Romano M, Nova-Lamperti E, Sunderland MW, Nerviani A, Scottà C, Bombardieri M, Quezada SA et al. ( 2021 ) . PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype . PLOS Biology vol. 19 , ( 4 )

Serrano-Blesa E, Porter A, Lendrem DW, Pitzalis C, Barton A, Treumann A, Isaacs JD ( 2021 ) . Robust Optimization of SWATH-MS workflow for human blood serum proteome analysis using a Quality by Design approach .

Rivellese F, Manou-Stathopoulou S, Mauro D, Goldmann K, Pyne D, Rajakariar R, Gordon P, Schafer P et al. ( 2021 ) . Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus . Lupus Science & Medicine vol. 8 , ( 1 )

Nalesso G, Thorup A-S, Eldridge SE, De Palma A, Kaur A, Peddireddi K, Blighe K, Rana S et al. ( 2021 ) . Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis . Scientific Reports vol. 11 , ( 1 )

Ferrari M, Onuoha SC, Fossati-Jimack L, Nerviani A, Alves PL, Pagani S, Deantonio C, Colombo F et al. ( 2021 ) . Novel Bispecific Antibody for Synovial-Specific Target Delivery of Anti-TNF Therapy in Rheumatoid Arthritis . Frontiers in Immunology vol. 12 ,

Pitzalis C, Humby F, Rivellese F, Nerviani A, Lewis M ( 2021 ) . Rituximab versus Tocilizumab in anti-TNF inadequate responder patients with Rheumatoid Arthritis (R4RA): a stratified, biopsy-driven, multi-centre, randomised, open label, controlled clinical trial – 16 week outcomes Article (Randomised Controlled Trial) . The Lancet

Boutet M-A, Courties G, Nerviani A, Le Goff B, Apparailly F, Pitzalis C, Blanchard F ( 2021 ) . Novel insights into macrophage diversity in rheumatoid arthritis synovium . Autoimmunity Reviews vol. 20 , ( 3 )

Silva-Gomes R, Mapelli SN, Boutet M-A, Mattiola I, Sironi M, Grizzi F, Colombo F, Supino D et al. ( 2021 ) . Expression and regulation of MS4A molecules in myeloid cells . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 51 , 166 - 167 .

Boutet MA, Nerviani A, Ribera GL, Leone R, Sironi M, Hands R, Rivellese F, Del Prete A et al. ( 2021 ) . Pentraxin-3 (PTX3) circulating and synovial expression levels correlate with rheumatoid arthritis severity and tissue infiltration independently of the response to conventional treatments . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 51 , 66 - 66 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou SA, Rivellese F, Lucchesi D, Goldmann K, Fossati-Jimack L et al. ( 2021 ) . Rituximab Prevents the Progression of B-cell Driven Inflammatory Infiltrate in the Minor Salivary Glands of Primary Sjogren's Syndrome by Downregulating Immunological Pathways Key in Ectopic Germinal Centre Organization: Results from the TRACTISS Trial . ARTHRITIS & RHEUMATOLOGY . vol. 73 , 2065 - 2066 .

Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G et al. ( 2021 ) . Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial . The Lancet vol. 397 , ( 10271 ) 305 - 317 .

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Romão VC, Fonseca JE, Pitzalis C ( 2020 ) . Elderly-onset rheumatoid arthritis is a unique disease subset associated with poor overall outcomes: Response to the letter by Haroon and Ayamer . Seminars in Arthritis and Rheumatism vol. 51 , ( 5 ) e11 - e12 .

Giacomelli R, Afeltra A, Bartoloni E, Berardicurti O, Bombardieri M, Bortoluzzi A, Carubbi F, Caso F et al. ( 2020 ) . The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus . Autoimmunity Reviews vol. 20 , ( 2 )

Fahmi A, MacBrayne A, Kyrimi E, McLachlan S, Humby F, Marsh W, Pitzalis C ( 2020 ) . Causal Bayesian Networks for Medical Diagnosis: A Case Study in Rheumatoid Arthritis . Conference: 2020 IEEE International Conference on Healthcare Informatics (ICHI) vol. 00 , 1 - 7 .

Nerviani A, Boutet M-A, Tan WSG, Goldmann K, Purkayastha N, Lajtos T, Hands R, Lewis M et al. ( 2020 ) . IL-23 skin and joint profiling in Psoriatic Arthritis: novel perspectives in understanding clinical responses to IL-23 inhibitors . Annals of the Rheumatic Diseases

Sciacca E, Surace A, Lewis M, Alaimo S, Latora V, Rivellese F, Pulvirenti A, Ferro A et al. ( 2020 ) . Novel Network Tool Highlights Key Features Associated with Disease Pathotypes and Response to Treatment in Early Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . Conference: ACR Convergence 2020 vol. 72 ,

Gomez EA, Colas RA, Souza PR, Hands R, Lewis MJ, Bessant C, Pitzalis C, Dalli J ( 2020 ) . Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis . Nature Communications vol. 11 , ( 1 )

Pontarini E, Murray-Brown WJ, Croia C, Lucchesi D, Conway J, Rivellese F, Fossati-Jimack L, Astorri E et al. ( 2020 ) . Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren’s syndrome with ectopic germinal centres and MALT lymphoma . Annals of the Rheumatic Diseases vol. 79 , ( 12 ) 1588 - 1599 .

Thorup A-S, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J et al. ( 2020 ) . ROR2 blockade as a therapy for osteoarthritis . Science Translational Medicine vol. 12 , ( 561 )

Pitzalis C, Choy EHS, Buch MH ( 2020 ) . Transforming clinical trials in rheumatology: towards patient-centric precision medicine . Nature Reviews Rheumatology vol. 16 , ( 10 ) 590 - 599 .

Eldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, GUAN Z, Lydon H, Thomas B et al. ( 2020 ) . Agrin induces long term osteochondral regeneration by supporting repair morphogenesis . Science Translational Medicine vol. 12 , ( 559 )

Cherlin S, Lewis MJ, Plant D, Nair N, Goldmann K, Tzanis E, Barnes MR, McKeigue P et al. ( 2020 ) . Investigation of genetically regulated gene expression and response to treatment in rheumatoid arthritis highlights an association between IL18RAP expression and treatment response . Annals of the Rheumatic Diseases vol. 79 , ( 11 ) 1446 - 1452 .

Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill DG, Soria AD, Jones SA et al. ( 2020 ) . Impaired Interleukin‐27–Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjögren's Syndrome . Arthritis & Rheumatology vol. 72 , ( 9 ) 1559 - 1570 .

Rivellese F, Rossi FW, Giorli G, Napolitano F, de Paulis A, Pitzalis C ( 2020 ) . Persistence of Mast Cell-Positive Synovitis in Early Rheumatoid Arthritis Following Treatment With Conventional Synthetic Disease Modifying Anti-Rheumatic Drugs . Frontiers in Pharmacology vol. 11 , 1051 - 1051 .

Alivernini S, MacDonald L, Elmesmari A, Finlay S, Tolusso B, Gigante MR, Petricca L, Di Mario C et al. ( 2020 ) . Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis . Nature Medicine vol. 26 , ( 8 ) 1295 - 1306 .

Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F et al. ( 2020 ) . Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal . Science Advances vol. 6 , ( 26 )

Bellan M, Quaglia M, Nerviani A, Mauro D, Lewis M, Goegan F, Gibbin A, Pagani S et al. ( 2020 ) . Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis . Clinical and Experimental Rheumatology vol. 39 , ( 1 ) 132 - 138 .

Rivellese F, Humby F, Lliso Ribera G, Nerviani A, Sciacca E, Giorli G, Hands R, Fossati-Jimack L et al. ( 2020 ) . OP0217 INVOLVEMENT OF LARGE JOINTS AT DISEASE PRESENTATION IS ASSOCIATED WITH DIVERSE HISTOPATHOLOGICAL FEATURES AND CLINICAL OUTCOMES IN EARLY RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 79 , 134.1 - 13135 .

Nerviani A, Boutet MA, Ghirardi GM, Lliso Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2020 ) . THU0082 MERTK SYNOVIAL EXPRESSION CORRELATES WITH TREATMENT RESPONSE IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 79 , 253.1 - 25253 .

Rivellese F, Pontarini E, Pitzalis C ( 2020 ) . Tertiary Lymphoid Organs in Rheumatoid Arthritis . Curr Top Microbiol Immunol

Romão VC, Humby F, Kelly S, Di Cicco M, Mahto A, Lazarou I, Hands R, Rocher-Ros V et al. ( 2020 ) . Treatment-resistant synovitis and radiographic progression are increased in elderly-onset rheumatoid arthritis patients: findings from a prospective observational longitudinal early arthritis cohort study . Seminars in Arthritis and Rheumatism vol. 50 , ( 4 ) 735 - 743 .

Nerviani A, Di Cicco M, Mahto A, Lliso-Ribera G, Rivellese F, Thorborn G, Hands R, Bellan M et al. ( 2020 ) . A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients . Frontiers in Immunology vol. 11 ,

Corsiero E, Carlotti E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M ( 2020 ) . H and L Chain Affinity Maturation and/or Fab N-Glycosylation Influence Immunoreactivity toward Neutrophil Extracellular Trap Antigens in Rheumatoid Arthritis Synovial B Cell Clones . The Journal of Immunology vol. 204 , ( 9 )

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Humby FC, Lewis M, Durez P, Buch MH, Bombardieri M, Rizvi H, Rivellese F, Fossati L et al. ( 2020 ) . O07 Randomised, open labelled clinical trial to investigate synovial mechanisms determining response: resistance to rituximab versus tocilizumab in RA patients failing TNF inhibitor therapy . Rheumatology . vol. 59 ,

Nerviani A, Lliso-Ribera G, Boutet M-A, Goldmann K, Rivellese F, Kelly S, Bombardieri M, Lewis M et al. ( 2020 ) . O20 Histological and molecular features of the diseased synovium in early untreated PsA in comparison with RA . Rheumatology . vol. 59 ,

Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill D, Soria AD, Jones S et al. ( 2020 ) . O31 IL-27 regulates the magnitude of ectopic germinal centres in experimental sialadenitis but fails to modulate IL-17 and IFNg production in CD4 T cells from patients with Sjögren's syndrome . Rheumatology . vol. 59 ,

MacBrayne ACB, Pott J, Petrovic V, Pitzalis C, Humby F ( 2020 ) . P214 Preliminary results: driving improvements in disease outcomes for rheumatoid arthritis patients using remote disease activity monitoring via smartphone app . Rheumatology vol. 59 , ( Supplement_2 )

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . P233 B cell-rich synovitis in early and established rheumatoid arthritis . Rheumatology vol. 59 , ( Supplement_2 )

Sciacca E, Alaimo S, Pulvirenti A, Latora V, Humby F, Ferro A, Lewis MJ, Pitzalis C ( 2020 ) . P22 Micro-RNA enriched pathway impact analysis applied to synovial RNA-seq in early rheumatoid arthritis identifies response prediction pathways . Rheumatology . Conference: British Society for Rheumatology Annual Conference 2020 vol. 59 ,

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure . Arthritis and Rheumatology

Huizinga TW, Holers VM, Anolik J, Brenner MB, Buckley CD, Bykerk V, Connolly SE, Deane KD et al. ( 2020 ) . Disruptive innovation in rheumatology: new networks of global public–private partnerships are needed to take advantage of scientific progress . Annals of the Rheumatic Diseases vol. 79 , ( 5 )

Pernicova I, Kelly S, Ajodha S, Sahdev A, Bestwick JP, Gabrovska P, Akanle O, Ajjan R et al. ( 2020 ) . Metformin to reduce metabolic complications and inflammation in patients on systemic glucocorticoid therapy: a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial . Lancet Diabetes and Endocrinology

John CR, Watson D, Russ D, Goldmann K, Ehrenstein M, Pitzalis C, Lewis M, Barnes M ( 2020 ) . M3C: Monte Carlo reference-based consensus clustering . Scientific Reports vol. 10 , ( 1 )

Pagani S, Bellan M, Mauro D, Castello LM, Avanzi GC, Lewis MJ, Sainaghi PP, Pitzalis C et al. ( 2020 ) . New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis . Disease Markers vol. 2020 , Article 1614627 ,

Muñoz-Atienza E, Flak MB, Sirr J, Paramonov NA, Aduse-Opoku J, Pitzalis C, Curtis MA ( 2020 ) . The P. gingivalis Autocitrullinome Is Not a Target for ACPA in Early Rheumatoid Arthritis . Journal of Dental Research vol. 99 , ( 4 ) 456 - 462 .

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . B CELL-RICH SYNOVITIS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 59 ,

Nerviani A, Lliso-Ribera G, Boutet M-A, Goldmann K, Rivellese F, Kelly S, Bombardieri M, Lewis M et al. ( 2020 ) . HISTOLOGICAL AND MOLECULAR FEATURES OF THE DISEASED SYNOVIUM IN EARLY UNTREATED PSA IN COMPARISON WITH RA . RHEUMATOLOGY . vol. 59 ,

Rivellese F, Humby F, Giorli G, Nerviani A, Hands R, Fossati-Jimack L, Thorborn G, Lewis M et al. ( 2020 ) . Histo-pathological Cellular Markers of Treatment Response to Rituximab and Tocilizumab in Matched Pre- and Post-treatment Synovial Biopsies from the R4RA Randomised Clinical Trial in Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,

Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill D, Soria AD, Jones S et al. ( 2020 ) . IL-27 REGULATES THE MAGNITUDE OF ECTOPIC GERMINAL CENTRES IN EXPERIMENTAL SIALADENITIS BUT FAILS TO MODULATE IL-17 AND IFNG PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJOGREN'S SYNDROME . RHEUMATOLOGY . vol. 59 ,

Nerviani A, Boutet M-A, Ghirardi GM, Lliso-Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2020 ) . MerTK Synovial Expression Correlates with Disease Activity and Treatment Response in Rheumatoid Arthritis Patients . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,

MacBrayne ACB, Pott J, Petrovic V, Pitzalis C, Humby F ( 2020 ) . PRELIMINARY RESULTS: DRIVING IMPROVEMENTS IN DISEASE OUTCOMES FOR RHEUMATOID ARTHRITIS PATIENTS USING REMOTE DISEASE ACTIVITY MONITORING VIA SMARTPHONE APP . RHEUMATOLOGY . vol. 59 ,

Humby FC, Lewis M, Durez P, Buch MH, Bombardieri M, Rizvi H, Rivellese F, Fossati L et al. ( 2020 ) . RANDOMISED, OPEN LABELLED CLINICAL TRIAL TO INVESTIGATE SYNOVIAL MECHANISMS DETERMINING RESPONSE: RESISTANCE TO RITUXIMAB VERSUS TOCILIZUMAB IN RA PATIENTS FAILING TNF INHIBITOR THERAPY . RHEUMATOLOGY . vol. 59 , 3 - + .

Meednu N, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, Bombardieri M, DiCarlo E, Orange D et al. ( 2020 ) . Role of NR4A Nuclear Receptor Family in RA Synovial Ectopic Lymphoid Neogenesis Revealed by Single Cell Profiling . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,

Pucino V, Certo M, Bulusu V, Cucchi D, Goldmann K, Pontarini E, Haas R, Smith J et al. ( 2019 ) . Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring . Cell Metabolism

Lliso-Ribera G, Humby F, Lewis M, Nerviani A, Mauro D, Rivellese F, Kelly S, Hands R et al. ( 2019 ) . Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases vol. 78 , ( 12 )

Tarn JR, Howard-Tripp N, Lendrem DW, Mariette X, Saraux A, Devauchelle-Pensec V, Seror R, Skelton AJ et al. ( 2019 ) . Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials . The Lancet Rheumatology vol. 1 , ( 2 ) e85 - e94 .

John CR, Watson D, Barnes MR, Pitzalis C, Lewis MJ ( 2019 ) . Spectrum: fast density-aware spectral clustering for single and multi-omic data . Bioinformatics vol. 36 , ( 4 ) 1159 - 1166 .

Boutet M-A, Nerviani A, Lliso-Ribera G, Lucchesi D, Prediletto E, Ghirardi GM, Goldmann K, Lewis M et al. ( 2019 ) . Interleukin-36 family dysregulation drives joint inflammation and therapy response in psoriatic arthritis . Rheumatology

Lewis MJ, Barnes MR, Blighe K, Goldmann K, Rana S, Hackney JA, Ramamoorthi N, John CR et al. ( 2019 ) . Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes . Cell Reports vol. 28 , 2455 - 2470 .

Romão VC, Polido-Pereira J, Barros R, Luís R, Vidal B, Vieira-Sousa E, Vitorino E, Humby F et al. ( 2019 ) . Efficacy, safety and sample quality of ultrasound-guided synovial needle biopsy in clinical practice and research: a prospective observational study . Arthritis Care and Research

Rodríguez-Ubreva J, de la Calle-Fabregat C, Li T, Ciudad L, Ballestar ML, Català-Moll F, Morante-Palacios O, Garcia-Gomez A et al. ( 2019 ) . Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis . Annals of the Rheumatic Diseases vol. 78 , ( 11 )

Humby F, Lewis M, Townsend MJ, Pitzalis C ( 2019 ) . Response to: ‘Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients’ by Buch et al . Annals of the Rheumatic Diseases vol. 79 , ( 11 ) e141 - e141 .

Flak MB, Colas RA, Muñoz-Atienza E, Curtis MA, Dalli J, Pitzalis C ( 2019 ) . Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis . JCI Insight vol. 4 , ( 13 )

El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ et al. ( 2019 ) . Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis . Journal of Autoimmunity

Mattiola I, Tomay F, De Pizzol M, Silva-Gomes R, Savino B, Gulic T, Doni A, Lonardi S et al. ( 2019 ) . The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis . Nature Immunology vol. 20 , ( 8 ) 1012 - 1022 .

Davies K, Mirza K, Tarn J, Howard-Tripp N, Bowman SJ, Lendrem D, Ng W-F ( 2019 ) . Fatigue in primary Sjögren’s syndrome (pSS) is associated with lower levels of proinflammatory cytokines: a validation study . Rheumatology International vol. 39 , ( 11 ) 1867 - 1873 .

Colombo F, Durigutto P, De Maso L, Biffi S, Belmonte B, Tripodo C, Oliva R, Bardini P et al. ( 2019 ) . Targeting CD34+ cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis . Journal of Autoimmunity vol. 103 ,

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Ribera GL, Nerviani A et al. ( 2019 ) . THU0058 B CELL SYNOVITIS AND CLINICAL PHENOTYPES IN RHEUMATOID ARTHRITIS AT DIFFERENT DISEASE STAGES . https://ard.bmj.com/content/78/Suppl_2 . Conference: Annual European Congress of Rheumatology, EULAR 2019 ( Madrid ) from: 12/06/2019 to: 15/06/2019 , 296.2 - 29297 .

Manou-Stathopoulou S, Rivellese F, Mauro D, Goldmann K, Pyne D, Schafer P, Bombardieri M, Pitzalis C et al. ( 2019 ) . AB0179 THE TRANSCRIPTION FACTORS IKZF1 AND IKZF3 CONTROL B CELL ACTIVATION AND DIFFERENTIATION IN SYSTEMIC LUPUS ERYTHEMATOSUS . Conference: Abstracts Accepted for Publication1548.1 - 151548 .

Nerviani A, Ribera GL, Boutet MA, Goldmann K, Kelly S, Bombardieri M, Lewis M, Humby F et al. ( 2019 ) . OP0113 HISTOLOGICAL AND MOLECULAR PORTRAIT OF THE SYNOVIAL TISSUE IN EARLY TREATMENT-NAÏVE PSORIATIC ARTHRITIS IN COMPARISON WITH RHEUMATOID ARTHRITIS . Conference: Oral Presentations130 - 131 .

Ribera GL, Humby F, Nerviani A, Lewis M, Kelly S, Bombardieri M, Goldmann K, Hands R et al. ( 2019 ) . OP0120 BASELINE CELLULAR AND MOLECULAR CHARACTERISTICS OF SYNOVIAL TISSUE AND RELATION WITH TNFI RESPONSE. RESULTS FROM THE PATHOBIOLOGY OF THE EARLY ARTHRITIS COHORT (PEAC) . Conference: Oral Presentations134 - 134 .

Lucchesi D, Coleby R, Pontarini E, Prediletto E, Hill D, Soria AD, Rivellese F, Pitzalis C et al. ( 2019 ) . OP0276 DENDRITIC CELL-DERIVED IL-27 REGULATES THE MAGNITUDE OF INDUCIBLE ECTOPIC GERMINAL CENTRES BUT FAILS TO DOWNMODULATE IL-17 PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJÖGREN’S SYNDROME . Conference: Oral Presentations220.1 - 22220 .

Pontarini E, Brown WM, Croia C, Lucchesi D, Rivellese F, Fossati-Jimack L, Ruscitti P, Prediletto E et al. ( 2019 ) . OP0279 A UNIQUE IL-21 SIGNATURE CHARACTERIZES LESIONAL AND CIRCULATING T-FOLLICULAR HELPER CELLS IN SJÖGREN’S SYNDROME PATIENTS WITH ECTOPIC GERMINAL CENTRES AND MALT LYMPHOMA . Conference: Oral Presentations221.1 - 22221 .

Purkayastha N, Ismail S, Taylor PC, Pitzalis C, Kelly S ( 2019 ) . OP0350 ULTRASOUND POWER DOPPLER SEMI-QUANTITATIVE SCORING, IS IT TIME WE MOVED TO A RED PIXEL DENSITY ALGORITHMIC PROGRAM TO DETERMINE TRUE TREATMENT RESPONSE? . Conference: Oral Presentations258.2 - 25259 .

Mauro D, Rivellese F, Manou-Stathopoulou S, Goldmann K, Pyne D, Ciccia F, Pitzalis C, Lewis M ( 2019 ) . SAT0025 THE EFFECT OF DIMETHYL FUMARATE ON PLASMABLAST DIFFERENTIATION TRANSCRIPTIONAL PROGRAMMES IN SYSTEMIC LUPUS ERYTHEMATOSUS . Conference: SATURDAY, 15 JUNE 20191077.1 - 101077 .

Nerviani A, Humby F, Ribera GL, Rivellese F, Kelly S, Hands R, Pitzalis C ( 2019 ) . THU0092 DEFINING A LEARNING CURVE FOR CLINICIANS PERFORMING ULTRASOUND-GUIDED DEFINING A LEARNING CURVE FOR CLINICIANS PERFORMING ULTRASOUND-GUIDED NEEDLE SYNOVIAL BIOPSIES: A RETROSPECTIVE ANALYSIS OF THE EXPERIENCE AT THE EXPERIMENTAL MEDICINE AND RHEUMATOLOGY, QUEEN MARY UNIVERSITY OF LONDON . Conference: Poster Presentations317.1 - 31317 .

Rivellese F, Manou-Stathopoulou S, Mauro D, Pontarini E, Lucchesi D, Congia M, Schafer P, Sutcliffe N et al. ( 2019 ) . THU0234 THE TRANSCRIPTION FACTORS IKAROS (IKZF1) AND AIOLOS (IKZF3) ARE EXPRESSED IN THE SALIVARY GLANDS OF SJÖGREN’S SYNDROME PATIENTS WITH LYMPHOID AGGREGATES AND MODULATE B CELL ACTIVATION IN VITRO . Conference: Poster Presentations394.2 - 39395 .

John CR, Watson D, Barnes M, Pitzalis C, Lewis MJ ( 2019 ) . Spectrum: Fast density-aware spectral clustering for single and multi-omic data .

Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D et al. ( 2019 ) . Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry . Nature Immunology vol. 20 , ( 7 ) 928 - 942 .

Spiliopoulou A, Colombo M, Plant D, Nair N, Cui J, Coenen MJ, Ikari K, Yamanaka H et al. ( 2019 ) . Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39 . Annals of the Rheumatic Diseases vol. 78 , ( 8 ) 1055 - 1061 .

Rivellese F, Rossi FW, Galdiero MR, Pitzalis C, de Paulis A ( 2019 ) . Mast Cells in Early Rheumatoid Arthritis . International Journal of Molecular Sciences vol. 20 , ( 8 )

Hackett KL, Davies K, Tarn J, Bragg R, Hargreaves B, Miyamoto S, McMeekin P, Mitchell S et al. ( 2019 ) . Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome . RMD Open vol. 5 , ( 1 )

Manou-Stathopoulou S, Rivellese F, Mauro D, Goldmann K, Pyne D, Schafer P, Bombardieri M, Pitzalis C et al. ( 2019 ) . 235 IKZF1 and IKZF3 inhibition impairs B cell differentiation and modulates gene expression in systemic lupus erythematosus . Conference: Abstractsa174.2 - a1a175 .

Twohig JP, Cardus Figueras A, Andrews R, Wiede F, Cossins BC, Derrac Soria A, Lewis MJ, Townsend MJ et al. ( 2019 ) . Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells . Nature Immunology vol. 20 , ( 4 ) 458 - 470 .

HUMBY F ( 2019 ) . Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients . Annals of the Rheumatic Diseases

Boutet M-A, Nerviani A, Pitzalis C ( 2019 ) . IL-36, IL-37, and IL-38 Cytokines in Skin and Joint Inflammation: A Comprehensive Review of Their Therapeutic Potential . International Journal of Molecular Sciences vol. 20 , ( 6 )

Boutet M-A, Nerviani A, Lliso-Ribera G, Goldmann K, Lewis M, Pitzalis C ( 2019 ) . P125 IL-36 axis is an emerging therapeutic target in psoriatic arthritis synovial tissue . Annals of the Rheumatic Diseases . Conference: Abstracts vol. 78 ,

Hensor EMA, McKeigue P, Ling SF, Colombo M, Barrett JH, Nam JL, Freeston J, Buch MH et al. ( 2019 ) . Validity of a two-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis . Rheumatology (Oxford)

Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V et al. ( 2019 ) . PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes . Annals of the Rheumatic Diseases vol. 78 , ( 5 ) 600 - 609 .

PITZALIS C, CORSIERO E, DELVECCHIO F, BOMBARDIERI M ( 2019 ) . B cells in the formation of Tertiary Lymphoid Organs in autoimmunity, transplantation and tumorigenesis . Current Opinion in Immunology vol. 57 , 46 - 52 .

Dorris ER, Tazzyman SJ, Moylett J, Ramamoorthi N, Hackney J, Townsend M, Muthana M, Lewis MJ et al. ( 2019 ) . The Autoimmune Susceptibility Gene C5orf30 Regulates Macrophage-Mediated Resolution of Inflammation . The Journal of Immunology vol. 202 , ( 4 ) 1069 - 1078 .

Humby F, Buch MH, Durez P, Lewis M, Bombardieri M, Rizvi H, Kelly S, Fosatti L et al. ( 2019 ) . A Randomised, Open Labelled Clinical Trial to Investigate Synovial Mechanisms Determining Response - Resistance to Rituximab versus Tocilizumab in Rheumatoid Arthritis Patients Failing TNF Inhibitor Therapy . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,

Corsiero E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M ( 2019 ) . Characterization of calreticulin, a stromal-derived autoantigens, recognized by RA synovial recombinant monoclonal antibodies . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 773 - 774 .

Pucino V, Certo M, Bulusu V, Goldmann K, Cucchi D, Haas R, Smith J, Blighe K et al. ( 2019 ) . Lactate influx into human CD4+T-cells, via SLC5A12, causes STAT3-and fatty acid synthesis-mediated IL17 expression and tissue retention . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 1276 - 1277 .

Rivellese F, Lliso-Ribera G, Nerviani A, Humby F, Pitzalis C ( 2019 ) . Persistence of B Cell-rich Synovitis Following Conventional Synthetic Disease Modifying Anti-Rheumatic Drug Treatment in Early Rheumatoid Arthritis Is Associated with Radiographic Progression Independently of Clinical Response . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,

Prediletto E, Pontarini E, Lucchesi D, Corsiero E, Pratesi F, Migliorini P, Pitzalis C, Bombardieri M ( 2019 ) . Synovial fluid fibroblast-like synoviocytes enhance long-term survival of EBV infected memory B cells in rheumatoid arthritis . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 791 - 791 .

Mauro D, Macaluso F, Nerviani A, Boutet M-A, Rizzo A, Alessandro R, Guggino G, Pitzalis C et al. ( 2019 ) . The Deubiquitinase TRABID Is a Potential Therapeutic Target in Spondyloarthritis . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,

Mattiola I, Tomay F, De Pizzol M, Silva-Gomes R, Savino B, Gulic T, Doni A, Lonardi S et al. ( 2019 ) . The macrophage tetraspan MS4A4A enhances Dectin-1-dependent NK cell-mediated resistance to metastasis . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 1517 - 1518 .

Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA et al. ( 2018 ) . The RA-MAP Consortium: a working model for academia-industry collaboration . Nat Rev Rheumatol vol. 14 , ( 1 ) 53 - 60 .

Just SA, Humby F, Lindegaard H, de Bellefon LM, Durez P, Vieira-Sousa E, Teixeira R, Stoenoiu M et al. ( 2018 ) . Patient-reported outcomes and safety in patients undergoing synovial biopsy: comparison of ultrasound-guided needle biopsy, ultrasound-guided portal and forceps and arthroscopic-guided synovial biopsy techniques in five centres across Europe . RMD Open vol. 4 , ( 2 )

Consortium R-M ( 2018 ) . Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data . RMD Open vol. 4 , ( 2 )

Cherlin S, Plant D, Taylor JC, Colombo M, Spiliopoulou A, Tzanis E, Morgan AW, Barnes MR et al. ( 2018 ) . Prediction of treatment response in rheumatoid arthritis patients using genome‐wide SNP data . Genetic Epidemiology vol. 42 , ( 8 ) 754 - 771 .

Purkayastha N, Humby F, Rocher-Ros V, Pitzalis C, Kelly S ( 2018 ) . Wrist ultrasound - the model method for grey-scale and power Doppler scoring . Annals of the Rheumatic Diseases vol. 78 , ( 3 )

Cecchinato V, D'Agostino G, Raeli L, Nerviani A, Schiraldi M, Danelon G, Manzo A, Thelen M et al. ( 2018 ) . Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis . Frontiers in Immunology vol. 9 , 2118 - 2118 .

Massey J, Plant D, Hyrich K, Morgan AW, Wilson AG, Spiliopoulou A, Colombo M, McKeigue P et al. ( 2018 ) . Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis . The Pharmacogenomics Journal vol. 18 , ( 5 ) 657 - 664 .

Corsiero E, Jagemann L, Bombardieri M, Pitzalis C ( 2018 ) . Generation of Recombinant Monoclonal Antibodies from Single B Cells Isolated from Synovial Tissue of Rheumatoid Arthritis Patients . Methods Mol Biol vol. 1845 , 159 - 187 .

Rivellese F, Mauro D, Nerviani A, Pagani S, Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM et al. ( 2018 ) . Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production . Annals of the Rheumatic Diseases vol. 77 , ( 12 )

Notarstefano C, Croia C, Pontarini E, Lucchesi D, Sutcliffe N, Tappuni A, Donati V, Pitzalis C et al. ( 2018 ) . A clinical and histopathological analysis of the anti-centromere antibody positive subset of primary Sjögren's syndrome . Clin Exp Rheumatol vol. 36 Suppl 112 , ( 3 ) 145 - 149 .

PITZALIS C, CORSIERO E, JAGEMANN L, PERRETTI M, BOMBARDIERI M ( 2018 ) . Characterization of a synovial B cell-derived 1 recombinant monoclonal antibody 2 targeting stromal calreticulin in the rheumatoid joints . Journal of Immunology

John C, Watson D, Russ D, Goldmann K, Ehrenstein M, Pitzalis C, Lewis M, Barnes M ( 2018 ) . M3C: Monte Carlo reference-based consensus clustering . Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob java.io.Serializable ,

Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F et al. ( 2018 ) . Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue . Arthritis Research & Therapy vol. 20 , ( 1 )

Nerviani A, Pitzalis C ( 2018 ) . Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer . Journal of Leukocyte Biology vol. 104 , ( 2 ) 333 - 341 .

Mauro D, Tsang V, Lucey-Clayton I, Rivellese F, Pagani S, Alam F, Pontarini E, Nerviani A et al. ( 2018 ) . FRI0271 Dimethyl fumarate inhibits ube2l3 mediated tlr7 signalling and autoreactive b cell development in sle . Annals of the Rheumatic Diseases . Conference: FRIDAY, 15 JUNE 2018 vol. 77 ,

Lliso-Ribera G, Humby F, Nerviani A, Boutet MA, Kelly S, Bombardieri M, Lewis M, Hands R et al. ( 2018 ) . OP0040 Synovial cell infiltration in acpa-ve patients displays similar signatures to other seronegative inflammatory arthritis. results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . Conference: WEDNESDAY, 13 JUNE 2018 vol. 77 ,

Just SA, Humby F, Lindegaard H, de Bellefon LM, Durez P, Vieira-Sousa E, Teixeira R, Stoenoiu M et al. ( 2018 ) . OP0278-HPR Patient reported outcomes and safety in patients undergoing synovial biopsy: comparison of arthroscopic, ultrasound-guided portal-forceps and ultrasound-guided needle biopsy techniques, in five centres across europe . Annals of the Rheumatic Diseases . Conference: FRIDAY, 15 JUNE 2018 vol. 77 ,

Boutet M-A, Nerviani A, Lliso-Ribera G, Goldmann K, Lewis M, Pitzalis C ( 2018 ) . SAT0024 Il-36 axis is an emerging therapeutic target in psoriatic arthritis synovial tissue . Annals of the Rheumatic Diseases . Conference: Saturday, 16 JUNE 2018 vol. 77 ,

Ruiz-Romero C, Picchi F, González-Rodríguez L, Fernández-Puente P, Hands R, Calamia V, Camacho-Encina M, Bessant C et al. ( 2018 ) . SAT0074 Identification of a protein panel useful for the prediction of response to methotrexate in rheumatoid arthritis patients . Annals of the Rheumatic Diseases . Conference: Saturday, 16 JUNE 2018 vol. 77 ,

Rivellese F, Nerviani A, Mauro D, Pagani S, Humby F, Pitzalis C ( 2018 ) . SAT0076 Synovial mast cells and responses to synthetic and biologic dmards in early and established rheumatoid arthritis . Annals of the Rheumatic Diseases . Conference: Saturday, 16 JUNE 2018 vol. 77 ,

Ruiz-Romero C, Picchi F, Fernández-Puente P, González-Rodríguez L, Hands R, Calamia V, Camacho-Encina M, Bessant C et al. ( 2018 ) . THU0052 A circulating protein signature correlates with synovial pathotypes in rheumatoid arthritis patients . Annals of the Rheumatic Diseases . Conference: THURSDAY, 14 JUNE 2018 vol. 77 ,

Nerviani A, Mauro D, Pagani S, Lliso-Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2018 ) . THU0061 Restricted axl synovial expression and increased cleavage of axl ectodomain correlate with highly inflamed synovitis and more severe rheumatoid arthritis . Annals of the Rheumatic Diseases . Conference: THURSDAY, 14 JUNE 2018 vol. 77 ,

Rivellese F, Congia M, Mauro D, Bombardieri M, Lewis M, Pitzalis C ( 2018 ) . THU0070 The transcription factors ikaros and aiolos are expressed in the synovial membrane of early rheumatoid arthritis patients in association with synovial lymphoid aggregates . Annals of the Rheumatic Diseases . Conference: THURSDAY, 14 JUNE 2018 vol. 77 ,

Purkayastha N, Tan WS, Mahto A, Lewis M, Lliso G, Nerviani A, Rocher V, Humby F et al. ( 2018 ) . THU0122 Imaging characterisation of remission in rheumatoid arthritis . Annals of the Rheumatic Diseases . Conference: THURSDAY, 14 JUNE 2018 vol. 77 ,

Taylor JC, Bongartz T, Massey J, Mifsud B, Spiliopoulou A, Scott IC, Wang J, Morgan M et al. ( 2018 ) . Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients . The Pharmacogenomics Journal vol. 18 , ( 4 ) 528 - 538 .

Mandelin AM, Homan PJ, Shaffer AM, Cuda CM, Dominguez ST, Bacalao E, Carns M, Hinchcliff M et al. ( 2018 ) . Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound‐Guided Synovial Biopsies in Rheumatoid Arthritis . Arthritis & Rheumatology vol. 70 , ( 6 ) 841 - 854 .

Cole S, Walsh A, Yin X, Wechalekar MD, Smith MD, Proudman SM, Veale DJ, Fearon U et al. ( 2018 ) . Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus . Arthritis Research & Therapy vol. 20 , ( 1 )

Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . 244 The clinical phenotype of inflammatory arthritis correlates with synovial immune cell infiltration: results from the pathobiology of early arthritis cohort . Rheumatology vol. 57 , ( suppl_3 )

Massey J, Plant D, Hyrich K, Morgan AW, Wilson AG, Spiliopoulou A, Colombo M, McKeigue P et al. ( 2018 ) . 248 Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis . Rheumatology vol. 57 , ( suppl_3 )

Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . O09 A lymphoid pathotype at baseline, in early inflammatory arthritis, significantly associates with requirement for biologic therapy at 12 months follow up: results from the pathobiology of early arthritis cohort . Rheumatology vol. 57 , ( suppl_3 )

Hensor EMA, McKeigue P, Buch MH, Barrett JH, Nam JL, Freeston J, Colombo M, Spiliopoulou A et al. ( 2018 ) . O12 Validity of a2-component imaging-derived disease activity score (2C-DAS28) for improved assessment of synovitis in early rheumatoid arthritis . Rheumatology vol. 57 , ( suppl_3 )

Fisher BA, Emery P, Pitzalis C, Bombardieri M, Bowman SJ ( 2018 ) . Response to: Can ultrasound of the major salivary glands assess histopathological changes induced by treatment with rituximab in primary Sjögren’s syndrome? . Annals of the Rheumatic Diseases vol. 78 , ( 4 )

Humby F, Romão VC, Manzo A, Filer A, Bugatti S, Vieira‐Sousa E, Kelly S, Wechalekar M et al. ( 2018 ) . A Multicenter Retrospective Analysis Evaluating Performance of Synovial Biopsy Techniques in Patients With Inflammatory Arthritis . Arthritis & Rheumatology vol. 70 , ( 5 ) 702 - 710 .

Thomas BL, Jones HR, Norling LV, Headland SE, Pitzalis C, Dell'Accio F, Perretti M ( 2018 ) . Neutrophil extracellular vesicles have a cartilage protective effect during inflammatory arthritis . Osteoarthritis and Cartilage . vol. 26 , s125 - s126 .

Fallas MA, Caxaria S, Sherwood J, Luyten F, Pitzalis C, Dell'Accio F ( 2018 ) . The role of GCP-2 in cartilage differentiation and repair . Osteoarthritis and Cartilage . vol. 26 ,

James K, Chipeta C, Parker A, Harding S, Cockell SJ, Gillespie CS, Hallinan J, Barone F et al. ( 2018 ) . B-cell activity markers are associated with different disease activity domains in primary Sjögren’s syndrome . Rheumatology vol. 57 , ( 7 ) 1222 - 1227 .

Guo Y, Walsh AM, Canavan M, Wechalekar MD, Cole S, Yin X, Scott B, Loza M et al. ( 2018 ) . Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression . PLoS One vol. 13 , ( 2 ) e0192704 - e0192704 .

Shikh ME, Sayed RE, Fossati-Jimack L, Pitzalis C ( 2018 ) . O001 Lymphoid tissue macrophages express peptidylarginine deiminase 2 and 4: new implications in citrullination and anti-citrulline antibodies production in autoimmune arthritis . Annals of the Rheumatic Diseases . Conference: Oral presentations vol. 77 ,

Lucchesi D, Pontarini E, Coleby R, Jones G, Hill D, Pitzalis C, Bombardieri M ( 2018 ) . P079 Interleukin-27 regulates the magnitude of the ectopic germinal centre response in a viral-inducible model of sialadenitis . Annals of the Rheumatic Diseases . Conference: Poster presentations vol. 77 ,

Boutet M-A, Nerviani A, Afflitto GG, Pitzalis C ( 2018 ) . Role of the IL-23/IL-17 Axis in Psoriasis and Psoriatic Arthritis: The Clinical Importance of Its Divergence in Skin and Joints . International Journal of Molecular Sciences vol. 19 , ( 2 )

Dumusc A, Ng W-F, James K, Griffiths B, Price E, Pease C, Emery P, Lanyon P et al. ( 2018 ) . Comparison of ESSDAI and ClinESSDAI in potential optimisation of trial outcomes in primary Sjögren’s syndrome: examination of data from the UK Primary Sjögren’s Syndrome Registry . Swiss Medical Weekly vol. 148 , ( 0506 )

Rhys HI, Dell'Accio F, Pitzalis C, Moore A, Norling LV, Perretti M ( 2018 ) . Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages . EBioMedicine vol. 29 , 60 - 69 .

Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . A LYMPHOID PATHOTYPE AT BASELINE, IN EARLY INFLAMMATORY ARTHRITIS, SIGNIFICANTLY ASSOCIATES WITH REQUIREMENT FOR BIOLOGIC THERAPY AT 12 MONTHS FOLLOW UP: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT . RHEUMATOLOGY . vol. 57 ,

Notarstefano C, Croia C, Pontarini E, Lucchesi D, Sutcliffe N, Tappuni A, Donati V, Pitzalis C et al. ( 2018 ) . A clinical and histopathological analysis of the anti-centromere antibody positive subset of primary Sjogren's syndrome . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 36 , ( 3 ) S145 - S149 .

Nerviani A, Humby F, Ribera GL, Tan WS, Boutet MA, Goldmann K, Bene F, Hands R et al. ( 2018 ) . Comparative Histologic and Molecular Analysis of Synovial Tissue in Early Treatment-Naive Psoriatic and Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,

Rivellese F, Mauro D, Congia M, Pontarini E, Schafer P, Bombardieri M, Pitzalis C, Lewis MJ ( 2018 ) . Expression and Functions of the Transcription Factors Ikaros and Aiolos in Sjogren's Syndrome and Systemic Lupus Erythematosus . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,

Massey J, Plant D, Hyrich K, Morgan AW, Wilson AG, Spiliopoulou A, Colombo M, McKeigue P et al. ( 2018 ) . GENOME-WIDE ASSOCIATION STUDY OF RESPONSE TO TUMOUR NECROSIS FACTOR INHIBITOR THERAPY IN RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 57 ,

Ruiz-Romero C, Picchi F, Fernandez P, Gonzalez L, Hands R, Calamia V, Camacho M, Bessant C et al. ( 2018 ) . Identification of a Panel of Circulating Proteins Associated to Synovial Pathotypes in Early Rheumatoid Arthritis Patients . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,

Ruiz-Romero C, Picchi F, Gonzalez L, Hands R, Calamia V, Fernandez P, Camacho M, Paz R et al. ( 2018 ) . Identification of a Protein Profile Useful to Predict Response to Methotrexate in Early Rheumatoid Arthritis Patients . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,

Cole S, Walsh A, Yin X, Wechalekar M, Smith M, Proudman SM, Veale DJ, Fearon U et al. ( 2018 ) . Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich rheumatoid arthritis, pre-rheumatoid arthritis and systemic lupus erythematosus . JOURNAL OF IMMUNOLOGY . vol. 200 ,

Lucchesi D, Pontarini E, Coleby R, Jones GW, Hill DG, Pitzalis C, Bombardieri M ( 2018 ) . Interleukin-27 regulates the magnitude of the ectopic germinal centre response in a virus-induced murine model of sialadenitis . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 36 , S244 - S244 .

Bottini A, Wu DJ, Ai R, LeRoux M, Bartok B, Bombardieri M, Zhang V, Doody KM et al. ( 2018 ) . Non-Receptor Protein Tyrosine Phosphatase 14 (PTPN14) Promotes YAP-Dependent Tgfbeta Signaling in RA FLS . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,

Corsiero E, Jagemann L, Pontarini E, Fossati-Jimack L, Pitzalis C, Bombardieri M ( 2018 ) . Single-cell VH and VL Ig gene analysis reveal clonal relationship between IgM plus neoplastic B cells and plasmablasts in SS patients with parotid MALT lymphoma . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 36 , S249 - S249 .

Pontarini E, Murray-Brown W, Croia C, Corsiero E, Fossati-Jimack L, Astorri E, Lucchesi D, Lepse N et al. ( 2018 ) . T follicular-helper cells (TFH) enrichment and follicular T regulatory cells (TFR) exclusion from ectopic germinal centers in salivary glands of Sjogren's Syndrome patients . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 36 , S291 - S291 .

Ribera GL, Humby F, Kelly S, Lewis M, Bornbardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . THE CLINICAL PHENOTYPE OF INFLAMMATORY ARTHRITIS CORRELATES WITH SYNOVIAL IMMUNE CELL INFILTRATION: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT . RHEUMATOLOGY . vol. 57 ,

Fisher BA, Everett CC, Rout J, O'Dwyer JL, Emery P, Pitzalis C, Ng W-F, Carr A et al. ( 2017 ) . Effect of rituximab on a salivary gland ultrasound score in primary Sjögren’s syndrome: results of the TRACTISS randomised double-blind multicentre substudy . Annals of the Rheumatic Diseases vol. 77 , ( 3 )

Bezzina OM, Gallagher P, Mitchell S, Bowman SJ, Griffiths B, Hindmarsh V, Hargreaves B, Price EJ et al. ( 2017 ) . Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy . Arthritis Care Res (Hoboken) vol. 69 , ( 11 ) 1714 - 1723 .

Lownik JC, Luker AJ, Damle SR, Cooley LF, El Sayed R, Hutloff A, Pitzalis C, Martin RK et al. ( 2017 ) . ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses . The Journal of Immunology vol. 199 , ( 7 ) 2305 - 2315 .

Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS et al. ( 2017 ) . Erratum: Synovial tissue research: a state-of-the-art review . Nature Reviews Rheumatology vol. 13 , ( 10 ) 630 - 630 .

Balasubramaniam G, Parker T, Turner D, Parker M, Scales J, Harnett P, Harrison M, Ahmed K et al. ( 2017 ) . Feasibility randomised multicentre, double-blind, double-dummy controlled trial of anakinra, an interleukin-1 receptor antagonist versus intramuscular methylprednisolone for acute gout attacks in patients with chronic kidney disease (ASGARD): protocol study . BMJ Open vol. 7 , ( 9 ) e017121 - e017121 .

Oni C, Mitchell S, James K, Ng W-F, Griffiths B, Hindmarsh V, Price E, Pease CT et al. ( 2017 ) . Eligibility for clinical trials in primary Sjögren’s syndrome: lessons from the UK Primary Sjögren’s Syndrome Registry . Rheumatology vol. 56 , ( 12 ) 2255 - 2255 .

Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Lin N-Y, Dietel K et al. ( 2017 ) . Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells . Nature Medicine vol. 23 , ( 8 ) 938 - 944 .

Humby F, Mahto A, Ahmed M, Barr A, Kelly S, Buch M, Pitzalis C, Conaghan PG ( 2017 ) . The Relationship Between Synovial Pathobiology and Magnetic Resonance Imaging Abnormalities in Rheumatoid Arthritis: A Systematic Review . J Rheumatol vol. 44 , ( 9 ) 1311 - 1324 .

Ursini F, Leporini C, Bene F, D’Angelo S, Mauro D, Russo E, De Sarro G, Olivieri I et al. ( 2017 ) . Anti-TNF-alpha agents and endothelial function in rheumatoid arthritis: a systematic review and meta-analysis . Scientific Reports vol. 7 , ( 1 )

Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS et al. ( 2017 ) . Synovial tissue research: a state-of-the-art review . Nature Reviews Rheumatology vol. 13 , ( 8 ) 463 - 475 .

Mandelin A, Homan P, Cuda C, Dominguez, Bridges S, Bathon J, Atkinson J, Fox D et al. ( 2017 ) . AB0220 The promise of ultrasound guided minimally invasive synovial biopsies in the united states . Annals of the Rheumatic Diseases . Conference: Abstracts Accepted for Publication vol. 76 ,

Fisher B, Everett C, Rout J, O'Dywer J, Emery P, Pitzalis C, Ng W-F, Carr A et al. ( 2017 ) . AB0444 Effect of rituximab on a salivary gland ultrasound score in primary sjÖgren's syndrome: results of the tractiss multicentre randomised trial sub-study . Annals of the Rheumatic Diseases . Conference: Abstracts Accepted for Publication vol. 76 ,

Rivellese F, Humby F, Nerviani A, Pagani S, Mauro D, de Paulis A, Marone G, Pitzalis C ( 2017 ) . FRI0030 Synovial mast cells identify patients with a severe phenotype in a cohort of dmard naÏve patients with early rheumatoid arthritis . Annals of the Rheumatic Diseases . Conference: Poster Presentations vol. 76 ,

Pucino V, Smith J, Cucchi D, Blighe K, Bombardieri M, Pitzalis C, Mauro C ( 2017 ) . FRI0076 LACTATE/SLC5A12-induced metabolic signalling network: a new target in rheumatoid arthritis . Annals of the Rheumatic Diseases . Conference: Poster Presentations vol. 76 ,

Lliso-Ribera G, Humby F, Kelly S, Bombardieri M, Lewis M, Hands R, Rocher V, Bene F et al. ( 2017 ) . FRI0088 Synovial pathobiology correlates with diagnostic subgroups in early inflammatory arthritis: results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . Conference: Poster Presentations vol. 76 ,

Corsiero E, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M ( 2017 ) . OP0175 Characterization of novel stromal-derived autoantigens recognized by ra synovial monoclonal antibodies . Annals of the Rheumatic Diseases . Conference: Oral Presentations vol. 76 ,

Pontarini E, Murray-Brown W, Croia C, Astorri E, Lucchesi D, Lepse N, Sutcliffe N, Tappuni A et al. ( 2017 ) . OP0300 Enrichment of T follicular-helper cells (TFH) and exclusion of t follicular-regulatory cells (TFR) from ectoPIC germinal centers in salivary glands of sjogren's syndrome patients . Annals of the Rheumatic Diseases . Conference: Oral Presentations vol. 76 ,

Walsh A, Canavan M, Guo Y, McGarry T, Yin X, Wechalekar, Smith, Proudman S et al. ( 2017 ) . THU0011 Immune signal 2 checkpoint molecule expression in rheumatoid arthritis disease progression . Annals of the Rheumatic Diseases . Conference: Poster Presentations vol. 76 ,

Lliso-Ribera G, Humby F, Kelly S, Bombardieri M, Lewis M, Hands R, Rocher V, Bene F et al. ( 2017 ) . THU0100 In early inflammatory arthritis a lymphoid pathotype signficantly associates with requirement for biologic therapy at 12 months follow up: results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . Conference: Poster Presentations vol. 76 ,

Humby F, Bugatti S, Filer A, Kelly S, Manzo A, Souza E, Romao V, Rocher V et al. ( 2017 ) . THU0667 A qualitative and quantitative comparison of synovial biopsy techniques during clinical trials of inflammatory arthritis . Annals of the Rheumatic Diseases . Conference: Poster Presentations vol. 76 ,

Muñoz-Atienza E, Aduse-Opoku J, Flak MB, Paramonov NA, Pitzalis C, Curtis MA ( 2017 ) . Generation and characterisation of Porphyromonas gingivalis mutant lacking peptidylarginine deiminase activity . Journal of Oral Microbiology vol. 9 , ( sup1 )

El Shikh MEM, El Sayed R, Pitzalis C ( 2017 ) . Isolation and Characterization of Mouse and Human Follicular Dendritic Cells . Methods Mol Biol vol. 1623 , 113 - 123 .

Guo Y, Walsh AM, Fearon U, Smith MD, Wechalekar MD, Yin X, Cole S, Orr C et al. ( 2017 ) . CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression . The Journal of Immunology vol. 198 , ( 11 ) 4490 - 4501 .

Humby FC, Al Balushi F, Lliso G, Cauli A, Pitzalis C ( 2017 ) . Can Synovial Pathobiology Integrate with Current Clinical and Imaging Prediction Models to Achieve Personalized Health Care in Rheumatoid Arthritis? . Front Med (Lausanne) vol. 4 , 41 - 41 .

Rivellese F, Nerviani A, Rossi FW, Marone G, Matucci-Cerinic M, de Paulis A, Pitzalis C ( 2017 ) . Mast cells in rheumatoid arthritis: friends or foes? . Autoimmunity Reviews vol. 16 , ( 6 ) 557 - 563 .

Thorup A-S, Eldridge SE, Caxaria S, Nalesso G, Thomas BL, Pitzalis C, Luyten F, Dell'Accio F ( 2017 ) . A Potency Assay for Assessing the Chondrogenic Efficiency of Bioactive Molecules in Human Cartilage in vivo . Osteoarthritis and Cartilage . vol. 25 ,

Eldridge SE, Thomas BL, Shanmuganathan K, Strachan D, Ali A, Thorup A-S, Caxaria S, Nalesso G et al. ( 2017 ) . Agrin inhibits canonical WNT signalling through LRP4 . Osteoarthritis and Cartilage . vol. 25 ,

Kaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A et al. ( 2017 ) . Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates . The Journal of Immunology vol. 198 , ( 7 ) 2876 - 2885 .

Caxaria S, Sherwood J, Roeder E, Luyten F, Pitzalis C, Dell'Accio F ( 2017 ) . The Role of CXCl6 in Cartilage Development and Homeostasis . Osteoarthritis and Cartilage . vol. 25 ,

Thomas BL, Nalesso G, Eldridge SE, Pitzalis C, Dell'accio F ( 2017 ) . WNT16 is up-regulated in the joint following inflammation . Osteoarthritis and Cartilage . vol. 25 ,

Bowman SJ, Everett CC, O'Dwyer JL, Emery P, Pitzalis C, Ng W-F, Pease CT, Price EJ et al. ( 2017 ) . Randomized Controlled Trial of Rituximab and cost-effectiveness analysis in treating fatigue and oral dryness in primary Sjogren's Syndrome . Arthritis Rheumatol

Corsiero E, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M ( 2017 ) . 08.34 Ra synovial recombinant monoclonal antibodies from single b cells target citrullinated calreticulin . Annals of the Rheumatic Diseases . Conference: Autoimmune inflammation vol. 76 ,

Lucchesi D, Pontarini E, Pitzalis C, Mavilio D, Bombardieri M ( 2017 ) . MYELOID CELLS DRIVE EARLY INFLAMMATION AND ORCHESTRATE SALIVARY GLANDS TERTIARY LYMPHOID STRUCTURES FORMATION IN A MODEL OF INDUCIBLE SIALADENITIS . ANNALS OF THE RHEUMATIC DISEASES . Conference: EWRR ( Athens ) from: 02/03/2017 to: 04/03/2017 , vol. 76 , A4 - A4 .

Bombardieri M, Lewis M, Pitzalis C ( 2017 ) . Ectopic lymphoid neogenesis in rheumatic autoimmune diseases . Nature Reviews Rheumatology

Zhang F, Slowikowski K, Fonseka C, Wei K, Gutierrez-Arcelus M, Lederer J, Hacohen N, Bykerk VP et al. ( 2017 ) . A Novel Statistical Method to Resolve Cellular Heterogeneity in Disease Tissues: Integrating Transcriptomic Data in Accelerating Medicines Partnership (AMP) - RA Network Phase 1 Data . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Eldridge S, Thomas B, Roelofs A, Nosrati B, Shanmuganathan K, Strachen D, Caxaria S, Ali A et al. ( 2017 ) . Agrin is a potent WNT inhibitor which supports the healing of osteochondral defects . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 98 , A6 - A6 .

Corsiero E, Jagemann L, Pitzalis C, Bombardieri M ( 2017 ) . Characterization of Novel Stromal-Derived Autoantigens Recognized By RA Synovial Monoclonal Antibodies . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Fisher B, Everett C, Rout J, O'Dwyer J, Emery P, Pitzalis C, Ng W-F, Carr A et al. ( 2017 ) . Effect of Rituximab on a Salivary Gland Ultrasound Score in Primary Sjgren's Syndrome: Results of Multicentre Double-Blind Randomised Controlled Trial Sub-Study . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Hill D, Liu X, Uceda J, Cossins B, Morgan J, Williams N, Andrews R, Williams A et al. ( 2017 ) . Global transcriptomic analysis identifies cytokineregulated pathways that determine discrete synovial pathotypes in inflammatory arthritis . CYTOKINE . vol. 100 , 107 - 108 .

Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Bozec A, Herrmann M et al. ( 2017 ) . IL-9-Producing Innate Lymphoid Cells - Keyplayers That Orchestrate Resolution of Chronic Inflammation in Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Davies K, Mirza K, Tarn J, Regan M, Vadivelu S, Clunie G, Andrews J, Price E et al. ( 2017 ) . Longitudinal Analysis of Different Therapeutic Strategies in Patients with Primary Sjogren's Syndrome . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Rao D, Donlin LT, Wei K, Meednu N, Turner J, McGeachy MJ, Mizoguchi F, Keegan J et al. ( 2017 ) . Methods for Generating Multiple High-Dimensional Analyses of Cryopreserved Synovial Tissue Developed By the Accelerating Medicines Partnership RA/SLE Network . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Rivellese F, Humby F, Pagani S, Nerviani A, Pitzalis C ( 2017 ) . Persistence of Mast Cell-Rich Synovitis Is Associated with Lack of Response to Synthetic Disease Modifying Anti-Rheumatic Drugs in Patients with Early Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Mauro D, Tsang V, Clayton-Lucey IA, Pagani S, Alam F, Pontarini E, Nerviani A, Pakozdi A et al. ( 2017 ) . Regulation of TLR7 Signalling By UBE2L3 Dependent Linear Ubiquitination Explains Dimethyl Fumarate Suppression of Autoreactive B Cell Development in SLE . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Secchi C, Doody KM, Svensson MND, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K et al. ( 2017 ) . Synergistic Reversal of Arthritis By Synoviocyte-Targeted Therapy and TNF Immunomodulation . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

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Homan PJ, Mandelin AMII, Dominguez S, Bacalao E, Bridges SLJ, Bathon JM, Atkinson J, Fox D et al. ( 2017 ) . Transcriptional Profiling of Synovial Macrophages from RA Patients to Capture Disease Heterogeneity . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Nerviani A, Pagani S, Mauro D, Humby F, Kelly S, Rivellese F, Ribera GL, Lewis MJ et al. ( 2017 ) . Tyrosine Kinase Receptor Axl Is Down Regulated in Highly Inflamed Rheumatoid Synovium and Negatively Correlates with Markers of Disease Activity . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

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Ng W-F, Miller A, Bowman SJ, Price EJ, Kitas GD, Pease C, Emery P, Lanyon P et al. ( 2016 ) . Physical activity but not sedentary activity is reduced in primary Sjögren's syndrome . Rheumatol Int vol. 37 , ( 4 ) 623 - 631 .

Barton A, Pitzalis C ( 2016 ) . Stratified medicine in rheumatoid arthritis—the MATURA programme . Rheumatology vol. 56 , ( 8 ) 1247 - 1250 .

Pucino V, Bombardieri M, Pitzalis C, Mauro C ( 2016 ) . Lactate at the crossroads of metabolism, inflammation, and autoimmunity . European Journal of Immunology vol. 47 , ( 1 ) 14 - 21 .

Corsiero E, Nerviani A, Bombardieri M, Pitzalis C ( 2016 ) . Ectopic Lymphoid Structures: Powerhouse of Autoimmunity . Front Immunol vol. 7 , Article 00430 , 430 - 430 .

Tan WSG, Kelly S, Pitzalis C ( 2016 ) . Targeted therapies: what they teach us about the pathogenesis of psoriasis and psoriatic arthritis . Expert Rev Clin Immunol vol. 13 , ( 3 ) 207 - 222 .

Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Mehr R et al. ( 2016 ) . Next-generation sequencing demonstrates dynamic recirculation of B cell clones in ectopic lymphoid structures of Sjogren's syndrome . EUROPEAN JOURNAL OF IMMUNOLOGY . Conference: European League Against Rheumatism vol. 46 , 939 - 940 .

Lazarou I, Kelly S, Humby F, Di Cicco M, Zou L, Rocher-Ros V, Hands RE, Ng N et al. ( 2016 ) . Ultrasound-guided synovial biopsy of the wrist does not alter subsequent clinical or ultrasound disease activity assessments: a prospective study for incorporation of imaging in clinical trials . Clinical and Experimental Rheumatology vol. 34 , ( 5 ) 802 - 807 .

Howard Tripp N, Tarn J, Natasari A, Gillespie C, Mitchell S, Hackett KL, Bowman SJ, Price E et al. ( 2016 ) . Fatigue in primary Sjögren's syndrome is associated with lower levels of proinflammatory cytokines . RMD Open vol. 2 , ( 2 ) e000282 - e000282 .

Nerviani A, DiCicco M, Humby F, Kelly S, Zou L, Lewis M, Hands R, Rocher V et al. ( 2016 ) . FRI0157 A Baseline Prediction Model for Response To Certolizumab-Pegol: Role of Synovial Histopathology . Annals of the Rheumatic Diseases . vol. 75 ,

Nerviani A, Tan WS, Mahto A, Di Cicco M, Lazarou I, Ng N, Purkayastha N, Bellan M et al. ( 2016 ) . FRI0442 Histopathology of Treatment-Naïve Psoriatic Synovitis: A Comparison with Early Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 75 ,

Mauro D, Lewis MJ, Pullabhatla V, Vyse S, Simpson M, Cunninghame-Graham D, Syvanen AC, Pitzalis C et al. ( 2016 ) . OP0232 C1qtnf4 Mutation Identified by Exome Sequencing Is Associated with Systemic Lupus Erythematosus and Dysregulation of Tnf-Induced Apoptosis . Annals of the Rheumatic Diseases vol. 75 , ( Suppl 2 )

Humby F, Dicicco M, Kelly S, Bombardieri M, Hands R, Rocher V, Zou L, Myles L et al. ( 2016 ) . OP0240 Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease Progression at 12 Months: Results from The Pathobiology of Early Arthritis Cohort . Annals of the Rheumatic Diseases vol. 75 , ( Suppl 2 )

Mahto A, Humby F, Gregoriadou S, Ng N, Blighe K, Zou L, Lewis M, Bombardieri M et al. ( 2016 ) . OP0263 Synovial B-Cell Gene Signature Predicts Response To Rituximab Therapy . Annals of the Rheumatic Diseases . vol. 75 ,

Genovese M, Fleischmann R, Furst D, Janssen N, Carter J, Dasgupta B, Pitzalis C, Vasyutin I et al. ( 2016 ) . SAT0148 Improvements in Patient-Reported Outcomes with Olokizumab Treatment in Patients with Active, Moderate To Severe Rheumatoid Arthritis Who Had Failed Previous Anti-TNF Therapy: Results from The Ra0056 Double-Blind, Randomized Controlled Study, and RA0057, Its Open-Label Extension . Annals of the Rheumatic Diseases . vol. 75 ,

Astorri E, Lucchesi D, Pitzalis C, Bombardieri M ( 2016 ) . Spontaneous and Inducible Animal Models of Sjögren's Syndrome . Sjogren's Syndrome: Novel Insights in Pathogenic, Clinical and Therapeutic Aspects ,

Mauro D, Lewis MJ, Pullabhatla V, Vyse S, Simpson M, Cunninghame-Graham D, Syvanen AC, Pitzalis C et al. ( 2016 ) . C1QTNF4 MUTATION IDENTIFIED BY EXOME SEQUENCING IS ASSOCIATED WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND DYSREGULATION OF TNF-INDUCED APOPTOSIS . ANNALS OF THE RHEUMATIC DISEASES . Conference: Annual European Congress of Rheumatology EULAR 2016 vol. 75 , 145 - 154 .

Rivellese F, Humby F, Kelly S, Nerviani A, Mauro D, Rocher-Ros V, El Shikh ME, de Paulis A et al. ( 2016 ) . SYNOVIAL MAST CELLS CORRELATE WITH LOCAL AND SYSTEMIC INFLAMMATION AND ARE FUNCTIONALLY ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS . Presented at: EULAR 2016 ,

Porter D, van Melckebeke J, Dale J, Messow CM, McConnachie A, Walker A, Munro R, McLaren J et al. ( 2016 ) . Tumour necrosis factor inhibition versus rituximab for patients with rheumatoid arthritis who require biological treatment (ORBIT): an open-label, randomised controlled, non-inferiority, trial . Lancet vol. 388 , ( 10041 ) 239 - 247 .

nalesso, thomas, sherwood JC, Yu J, Addimanda O, Eldridge SE, Thorup, Dale L et al. ( 2016 ) . WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis . Annals of Rheumatic Diseases

Nerviani A, DiCicco M, Kelly S, Humby F, Hands R, Zou L, Lewis M, Rocher V et al. ( 2016 ) . FIBROID SYNOVIAL PATHOTYPE AND TYROSINE KINASE AXL CORRELATE WITH POOR CLINICAL RESPONSE TO CERTOLIZUMAB PEGOL IN RHEUMATOID ARTHRITIS PATIENTS . Rheumatology . Conference: Rheumatology 2016 from: 26/09/2016 to: 28/04/2016 , vol. 55 , 61 - 61 .

Lepse N, Nerviani A, Pitzalis C, Bombardieri M ( 2016 ) . 069 T Follicular Helper–Like Cells in the Rheumatoid Arthritis Synovium are Selectively Associated with Interleukin-21 Production and Ectopic Lymphoid Structures . Rheumatology vol. 55 , ( suppl_1 ) i89 - i89 .

Rivellese F, Humby F, Kelly S, Rocher V, Pitzalis C ( 2016 ) . 071 Synovial Mast Cells Correlate with Inflammation and Cellular Infiltration and are Associated with Ectopic Lymphoid Structures in Patients with Early Rheumatoid Arthritis . Rheumatology vol. 55 , ( suppl_1 ) i89 - i90 .

Lewis MJ, Vyse S, Shields AM, Zou L, Khamashta M, Gordon PA, Pitzalis C, Vyse TJ et al. ( 2016 ) . 205 Correlation of Soluble Vascular Cell Adhesion Molecule 1 with B Cell Activation and Plasma Cells in Systemic Lupus Erythematosus . Rheumatology vol. 55 , ( suppl_1 ) i145 - i146 .

Pitzalis C ( 2016 ) . I27 Stratified Medicine Approaches in Rheumatoid Arthritis . Rheumatology vol. 55 , ( suppl_1 ) i5 - i5 .

DiCicco M, Humby F, Kelly S, Bombardieri M, Rebecca H, Rocher V, Zou L, Myles L et al. ( 2016 ) . O49 Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease Progression at 12 Months: Results from the Pathobiology of Early Arthritis Cohort . Rheumatology vol. 55 , ( suppl_1 ) i59 - i59 .

Lewis MJ, Vyse S, Shields AM, Zou L, Khamashta M, Gordon PA, Pitzalis C, Vyse TJ et al. ( 2016 ) . CORRELATION OF SOLUBLE VASCULAR CELL ADHESION MOLECULE 1 WITH B CELL ACTIVATION AND PLASMA CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS . RHEUMATOLOGY . Conference: British Society for Rheumatology annual conference 2016 vol. 55 , 145 - 146 .

Eldridge SE, Petrycki E, Pitzalis C, Whiteford J, Dell'Accio F ( 2016 ) . MMP3 cleaves agrin in cartilage and reduces its chondrogenic potency . Osteoarthritis and Cartilage . vol. 24 ,

Nalesso G, Wagner K, Bertrand J, Sherwood JC, Thomas BL, Eldridge SE, Pitzalis C, Dell'Accio F ( 2016 ) . Pharmacological Blockade of CAMKII is Detrimental for Osteoarthritis Progression . Osteoarthritis and Cartilage . Conference: 2016 OARSI World Congress on Osteoarthritis vol. 24 (Suppl 1) , S149 - S149 .

Corsiero E, Carlotti E, Prediletto E, Jagemann L, Pitzalis C, Bombardieri M ( 2016 ) . A2.04 The role of somatic hypermutation and n-glycosylation in the anti-nets immunoreactivity of ra synovial monoclonal antibodies . Annals of the Rheumatic Diseases . vol. 75 ,

Lepse N, Nerviani A, Pitzalis C, Bombardieri M ( 2016 ) . A2.30 TFH-like cells in the ra synovium are selectively associated with IL-21 production and ectopic lymphoid structures . Annals of the Rheumatic Diseases . vol. 75 ,

Rivellese F, de Paulis A, Marone G, Pitzalis C, Toes REM ( 2016 ) . Reply . Arthritis & Rheumatology vol. 68 , ( 3 ) 769 - 770 .

De Groof A, Ducreux J, Humby F, Nzeusseu Toukap A, Badot V, Pitzalis C, Houssiau FA, Durez P et al. ( 2016 ) . Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy . Arthritis Research & Therapy vol. 18 , ( 1 )

Lewis MJ, Vyse S, Shields AM, Zou L, Khamashta M, Gordon PA, Pitzalis C, Vyse TJ et al. ( 2016 ) . Improved monitoring of clinical response in Systemic Lupus Erythematosus by longitudinal trend in soluble vascular cell adhesion molecule-1 . Arthritis Research & Therapy vol. 18 , ( 1 )

Astorri E, Lucchesi D, Pitzalis C, Bombardieri M ( 2016 ) . Chapter 7 Spontaneous and Inducible Animal Models of Sjögren’s Syndrome . Sjogren's Syndrome , Elsevier

Oni C, Mitchell S, James K, Ng W-F, Griffiths B, Hindmarsh V, Prices E, Pease CT et al. ( 2016 ) . Eligibility for clinical trials in primary Sjogren's syndrome: lessons from the UK Primary Sjogren's Syndrome Registry . RHEUMATOLOGY vol. 55 , ( 3 ) 544 - 552 .

Guo Y, Walsh A, Fearon U, Smith MD, Wechalekar MD, Yin X, Cole S, Orr C et al. ( 2016 ) . Gene Enrichment Analysis Identifies Active CD40-CD40L Signaling in Early and Established Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 68 ,

Taylor JC, Verstappen S, Wang J, Bongartz T, Scott I, Emery P, Pitzalis C, Barton A et al. ( 2016 ) . Genome-Wide Meta-Analysis of Response to Methotrexate in Rheumatoid Arthritis Patients on behalf of the MATURA Consortium . GENETIC EPIDEMIOLOGY . vol. 40 , 666 - 667 .

Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Nerviani A, Rocher-Ros V, Cardus A, Williams AS et al. ( 2016 ) . Interleukin-27 inhibits synovial lymphoid neogenesis in inflammatory arthritis . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 46 , 1024 - 1024 .

Pitzalis C ( 2016 ) . STRATIFIED MEDICINE APPROACHES IN RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 55 , 5 - 5 .

DiCicco M, Humby F, Kelly S, Bombardieri M, Rebecca H, Rocher V, Zou L, Myles L et al. ( 2016 ) . SYNOVIAL LYMPHOCYTIC AGGREGATES ASSOCIATE WITH HIGHLY ACTIVE RA AND PREDICT EROSIVE DISEASE PROGRESSION AT 12 MONTHS: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT . RHEUMATOLOGY . vol. 55 , 59 - 59 .

Rivellese F, Humby F, Kelly S, Rocher V, Pitzalis C ( 2016 ) . SYNOVIAL MAST CELLS CORRELATE WITH INFLAMMATION AND CELLULAR INFILTRATION AND ARE ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 55 , 89 - 90 .

Rivellese F, Humby F, Kelly S, de Paulis A, Marone G, Pitzalis C ( 2016 ) . Synovial Mast Cells Associate with High Disease Activity and Predict Radiographic Progression at 12 Months in Patients with Early Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 68 ,

Lepse N, Nerviani A, Pitzalis C, Bombardieri M ( 2016 ) . T FOLLICULAR HELPER-LIKE CELLS IN THE RHEUMATOID ARTHRITIS SYNOVIUM ARE SELECTIVELY ASSOCIATED WITH INTERLEUKIN-21 PRODUCTION AND ECTOPIC LYMPHOID STRUCTURES . RHEUMATOLOGY . vol. 55 , 89 - 89 .

Corsiero E, Carlotti E, Prediletto E, Jagemann L, Pitzalis C, Bombardieri M ( 2016 ) . The role of somatic hypermutation and N-glycosylation in the anti-NET immunoreactivity of RA synovial monoclonal antibodies . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 46 , 116 - 117 .

Hensor EMA, McKeigue P, Conaghan PG, Buch MH, Barrett JH, Nam JL, Colombo M, Spiliopoulou A et al. ( 2016 ) . Validity of a 2-Component Disease Activity Score for Accurate Assessment of Synovitis in Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 68 ,

James K, Al-Ali S, Tarn J, Cockell SJ, Gillespie CS, Hindmarsh V, Locke J, Mitchell S et al. ( 2015 ) . A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren’s Syndrome . PLOS ONE vol. 10 , ( 12 )

Astorri E, Sutcliffe N, Richards PS, Suchak K, Pitzalis C, Bombardieri M, Tappuni AR ( 2015 ) . Ultrasound of the salivary glands is a strong predictor of labial gland biopsy histopathology in patients with sicca symptoms . Journal of Oral Pathology and Medicine vol. 45 , ( 6 ) 450 - 454 .

Corsiero E, Bombardieri M, Carlotti E, Pratesi F, Robinson W, Migliorini P, Pitzalis C ( 2015 ) . Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs . Annals of the Rheumatic Diseases1866 - 1875 .

Sherwood J, Bertrand J, Nalesso G, Poulet B, Pitsillides A, Brandolini L, Karystinou A, De Bari C et al. ( 2015 ) . A homeostatic function of CXCR2 signalling in articular cartilage . Ann Rheum Dis vol. 74 , ( 12 ) 2207 - 2215 .

Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A et al. ( 2015 ) . Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis . Science Translational Medicine vol. 7 , ( 315 )

Ferrari M, Onuoha SC, Pitzalis C ( 2015 ) . Going with the flow: harnessing the power of the vasculature for targeted therapy in rheumatoid arthritis . Drug Discovery Today vol. 21 , ( 1 ) 172 - 179 .

Oni C, Mitchell S, James K, Ng W-F, Griffiths B, Hindmarsh V, Price E, Pease CT et al. ( 2015 ) . Eligibility for clinical trials in primary Sjögren’s syndrome: lessons from the UK Primary Sjögren’s Syndrome Registry . Rheumatology vol. 55 , ( 3 ) 544 - 552 .

Humby F, Kelly S, Hands R, Rocher V, DiCicco M, Ng N, Zou L, Bugatti S et al. ( 2015 ) . Use of ultrasound-guided small joint biopsy to evaluate the histopathologic response to rheumatoid arthritis therapy: recommendations for application to clinical trials . Arthritis Rheumatol vol. 67 , ( 10 ) 2601 - 2610 .

Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Nerviani A, Rocher-Ros V, Cardus A, Williams AS et al. ( 2015 ) . Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis . Journal of Experimental Medicine vol. 212 , ( 11 ) 1793 - 1802 .

Onuoha SC, Ferrari M, Sblattero D, Pitzalis C ( 2015 ) . Rational Design of Antirheumatic Prodrugs Specific for Sites of Inflammation . Arthritis & Rheumatology vol. 67 , ( 10 ) 2661 - 2672 .

Rivellese F, Suurmond J, Habets K, Dorjée AL, Ramamoorthi N, Townsend MJ, de Paulis A, Marone G et al. ( 2015 ) . Ability of Interleukin‐33– and Immune Complex–Triggered Activation of Human Mast Cells to Down‐Regulate Monocyte‐Mediated Immune Responses . Arthritis & Rheumatology vol. 67 , ( 9 ) 2343 - 2353 .

Eldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J et al. ( 2015 ) . Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo . Annals of the Rheumatic Diseases vol. 75 , ( 6 )

Barone F, Nayar S, Campos J, Cloake T, Withers DR, Toellner K-M, Zhang Y, Fouser L et al. ( 2015 ) . IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs . Proceedings of the National Academy of Sciences of the United States of America vol. 112 , ( 35 ) 11024 - 11029 .

Haas R, Smith J, Rocher-Ros V, Nadkarni S, Montero-Melendez T, D’Acquisto F, Bland EJ, Bombardieri M et al. ( 2015 ) . Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions . PLOS Biology vol. 13 , ( 7 )

Corsiero E, Carlotti E, Pitzalis C, Bombardieri M ( 2015 ) . FRI0007 The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETS)-Citrullinated Autoantigens of Ra Synovial Monoclonal Antibodies . Annals of the Rheumatic Diseases . vol. 74 ,

Carlotti E, Floyd J, Murray-Brown W, Barnes M, Mehr R, Bombardieri M, Pitzalis C ( 2015 ) . FRI0008 Longitudinal Analysis of the IGH-VH Gene by High-Throughput Sequencing in Early Rheumatoid Arthritis Paired Biopsies and its Association with Response to Dmards . Annals of the Rheumatic Diseases . vol. 74 ,

Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Mehr R et al. ( 2015 ) . FRI0020 Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjögren's Syndrome . Annals of the Rheumatic Diseases . vol. 74 ,

Ferrari M, Onuoha SC, Sblattero D, Pitzalis C ( 2015 ) . FRI0103 Synovial Specific Prodrug for the Next Generation of Anti-TNF Therapy in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 74 ,

Komarowska I, Coe D, Wang G, Haas R, Mauro C, Kishore M, Cooper D, Nadkarni S et al. ( 2015 ) . Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release . Immunity vol. 42 , ( 6 ) 1087 - 1099 .

Decourcey J, Nerviani A, Melgar S, Bulfone-Paus S, Loscher CE, Bombardieri M, Pitzalis C ( 2015 ) . OP0117 Snare Regulation of TH17 Cells and Ectopic Lymphoid Structure (ELS) Formation in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 74 ,

De Groof A, Humby F, Ducreux J, Kelly S, Toukap AN, Pitzalis C, Durez P, Lauwerys B ( 2015 ) . OP0129 Higher Expression of TNF Alpha-Induced Genes in the Synovium of Early RA Patients Correlates with Disease Activity, and Predicts Absence of Response to First Line Therapy . Annals of the Rheumatic Diseases . vol. 74 ,

Tan WS, Bellan M, Nerviani A, Di Cicco M, Mahto A, Lazarou I, Hands R, Humby F et al. ( 2015 ) . OP0208 Synovial Immunopathology Defines Clinical Responsiveness to Dmard Therapy in Early Psoriatic Arthritis: A Pre- and Post-Treatment Mechanistic Study Using a Minimally Invasive Ultrasound-Guided Synovial Biopsy Procedure . Annals of the Rheumatic Diseases . vol. 74 ,

Nayar S, Campos J, Cloake T, Bowman S, Bombardieri M, Pitzalis C, Luther S, Buckley C et al. ( 2015 ) . SAT0005 IL22 Regulates Autoantibody Production by Inducing Lymphoid Chemokine Expression in Tertiary Lymphoid Organs . Annals of the Rheumatic Diseases . vol. 74 ,

Rivellese F, Suurmond J, Habets K, Dorjée AL, de Paulis A, Marone G, Pitzalis C, Huizinga TW et al. ( 2015 ) . THU0024 Human Mast Cells Stimulated with IL-33 and Immune Complexes Down-Regulate Monocyte Activation in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 74 ,

Nerviani A, Humby F, Kelly S, Bombardieri M, Pitzalis C ( 2015 ) . THU0033 A Functional Inhibitory Role for the GAS6/MERTK Axis in Modulating Synovial Inflammation in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 74 ,

Romao VC, DiCicco M, Lazarou I, Mahto A, Fonseca JE, Kelly S, Humby F, Pitzalis C ( 2015 ) . THU0116 Higher Ultrasound Synovitis in Elderly-Onset Rheumatoid Arthritis as Compared to Younger-Onset: THE Barts Early Arthritis Cohort . Annals of the Rheumatic Diseases . vol. 74 ,

Humby F, Kelly S, Bugatti S, Manzo A, Filer A, Mahto A, Fonseca JE, Lauwerys B et al. ( 2015 ) . Evaluation of Minimally Invasive, Ultrasound-guided Synovial Biopsy Techniques by the OMERACT Filter — Determining Validation Requirements . The Journal of Rheumatology vol. 43 , ( 1 ) 208 - 213 .

Mahto A, Lazarou I, Ng N, DiCicco M, Tan G, Humby F, Pitzalis C, Kelly S ( 2015 ) . 109. An Essential Part of the Rheumatologist's Toolkit? An Audit of a Rheumatology Led Ultrasound Guided Synovial Biopsy Service . Rheumatology vol. 54 , ( suppl_1 ) i93 - i94 .

Sin W, Tan G, Di Cicco M, Mahto A, Lazarou I, Hands R, Kelly S, Pitzalis C ( 2015 ) . 229. A Comparison of Clinical and Synovial Immunohistochemical Characteristics between Psoriatic Arthritis and Rheumatoid Arthritis in an Early Arthritis Cohort . Rheumatology vol. 54 , ( suppl_1 ) i138 - i138 .

Shields AM, Vyse S, Walczak H, Lehner PH, Pitzalis C, Spector TD, Vyse TJ, Lewis MJ ( 2015 ) . O37. The Autoimmune Risk Gene UBE2L3 is Highly Expressed During B Cell Proliferation and is Correlated with Plasmablast and Plasma Cell Expansion in SLE . Rheumatology vol. 54 , ( suppl_1 ) i41 - i41 .

Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Lazarou I, Hands RE, Rocher V et al. ( 2015 ) . Young Investigator AwadrI32. Synovial Pathotype Predicts Response to TNF-Alpha Inhibitors In Patients With Rheumatoid Arthritis . Rheumatology vol. 54 , ( suppl_1 ) i6 - i6 .

Lendrem D, Mitchell S, McMeekin P, Gompels L, Hackett K, Bowman S, Price E, Pease CT et al. ( 2015 ) . Do the EULAR Sjögren's syndrome outcome measures correlate with health status in primary Sjögren's syndrome? . Rheumatology (Oxford) vol. 54 , ( 4 ) 655 - 659 .

Kelly S, Bombardieri M, Humby F, Ng N, Marrelli A, Riahi S, DiCicco M, Mahto A et al. ( 2015 ) . Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early Rheumatoid Arthritis: an observational study . Arthritis Res Ther vol. 17 , ( 1 )

Kelly S, Bombardieri M, Humby F, Ng N, Marrelli A, Riahi S, DiCicco M, Mahto A et al. ( 2015 ) . Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early rheumatoid arthritis: an observational study . Arthritis Research & Therapy vol. 17 , ( 1 )

Ferrari M, Onuoha SC, Pitzalis C ( 2015 ) . Trojan horses and guided missiles: targeted therapies in the war on arthritis . Nature Reviews Rheumatology vol. 11 , ( 6 ) 328 - 337 .

Kelly S, Humby F, Filer A, Ng N, Di Cicco M, Hands RE, Rocher V, Bombardieri M et al. ( 2015 ) . Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients . Ann Rheum Dis vol. 74 , ( 3 ) 611 - 617 .

Romão, DiCicco M, Mahto A, Lazarou I, Fonseca J, Kelly S, Humby F, Pitzalis C ( 2015 ) . A7.6 Clinical and pathological differences of elderly- and younger-onset rheumatoid arthritis in an early arthritis cohort . Annals of the Rheumatic Diseases . vol. 74 , a76 - a77 .

Ferrari M, Onuoha S, Sblattero D, Pitzalis C ( 2015 ) . A8.18 Tissue specific pro-drug for the next generation of anti-TNF therapy in rheumatoid arthritis . Annals of the Rheumatic Diseases . vol. 74 , a88 - a89 .

Sin W, Tan G, Di Cicco M, Mahto A, Lazarou I, Hands R, Kelly S, Pitzalis C ( 2015 ) . A COMPARISON OF CLINICAL AND SYNOVIAL IMMUNOHISTOCHEMICAL CHARACTERISTICS BETWEEN PSORIATIC ARTHRITIS AND RHEUMATOID ARTHRITIS IN AN EARLY ARTHRITIS COHORT . RHEUMATOLOGY . vol. 54 , 138 - 138 .

Mahto A, Lazarou I, Ng N, DiCicco M, Tan G, Humby F, Pitzalis C, Kelly S ( 2015 ) . AN ESSENTIAL PART OF THE RHEUMATOLOGIST'S TOOLKIT? AN AUDIT OF A RHEUMATOLOGY LED ULTRASOUND GUIDED SYNOVIAL BIOPSY SERVICE . RHEUMATOLOGY . vol. 54 , 93 - 94 .

Nayar S, Campos J, Cloake T, Bowman S, Bombardieri M, Pitzalis C, Luther S, Buckley C et al. ( 2015 ) . IL22 Regulates Autoantibody Production by Inducing Lymphoid Chemokine Expression in Tertiary Lymphoid Organs . SCANDINAVIAN JOURNAL OF IMMUNOLOGY . vol. 81 , 425 - 425 .

Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Mehr R et al. ( 2015 ) . Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjogren's Syndrome . SCANDINAVIAN JOURNAL OF IMMUNOLOGY . vol. 81 , 401 - 402 .

Bowman S, Everett C, Bombardieri M, Busch R, Emery P, Hall F, Pease CT, Pitzalis C et al. ( 2015 ) . Preliminary Results of a Double-Blind Randomised Trial of Rituximab Anti-B-Cell Therapy in Patients with Primary Sjogrens Syndrome . ARTHRITIS & RHEUMATOLOGY vol. 67 ,

Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Lazarou I, Hands RE, Rocher V et al. ( 2015 ) . SYNOVIAL PATHOTYPE PREDICTS RESPONSE TO TNF-ALPHA INHIBITORS IN PATIENTS WITH RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 54 , 6 - 6 .

DiCicco M, Humby F, Kelly S, Hands R, Ng N, Mahto A, Lazarou I, Rocher V et al. ( 2015 ) . Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease at 12 Months: Results from the Pathobiology of Early Arthritis Cohort . ARTHRITIS & RHEUMATOLOGY vol. 67 ,

Romão VC, Pitzalis C ( 2015 ) . Synovial heterogeneity in rheumatoid arthritis: the key for rational patient stratification? . ARP Rheumatology vol. 40 , ( 1 ) 6 - 8 .

Shields AM, Vyse S, Walczak H, Lehner PH, Pitzalis C, Spector TD, Vyse TJ, Lewis MJ ( 2015 ) . THE AUTOIMMUNE RISK GENE UBE2L3 IS HIGHLY EXPRESSED DURING B CELL PROLIFERATION AND IS CORRELATED WITH PLASMABLAST AND PLASMA CELL EXPANSION IN SLE . RHEUMATOLOGY . vol. 54 , 41 - 41 .

Corsiero E, Carlotti E, Pitzalis C, Bombardieri M ( 2015 ) . The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETs)-Citrullinated Autoantigens of RA Synovial Monoclonal Antibodies . ARTHRITIS & RHEUMATOLOGY vol. 67 ,

Astorri E, Nerviani A, Bombardieri M, Pitzalis C ( 2015 ) . Towards a stratified targeted approach with biologic treatments in rheumatoid arthritis: role of synovial pathobiology . Current Pharmaceutical Design vol. 21 , ( 17 ) 2216 - 2224 .

Corsiero E, Sutcliffe N, Pitzalis C, Bombardieri M ( 2014 ) . Accumulation of Self-Reactive Naïve and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sjögren’s Syndrome . PLOS ONE vol. 9 , ( 12 )

Bugatti S, Manzo A, Vitolo B, Benaglio F, Binda E, Scarabelli M, Humby F, Caporali R et al. ( 2014 ) . High expression levels of the B cell chemoattractant CXCL13 in rheumatoid synovium are a marker of severe disease . Rheumatology (Oxford) vol. 53 , ( 10 ) 1886 - 1895 .

Genovese MC, Fleischmann R, Furst D, Janssen N, Carter J, Dasgupta B, Bryson J, Duncan B et al. ( 2014 ) . Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study . Ann Rheum Dis vol. 73 , ( 9 ) 1607 - 1615 .

Croia C, Astorri E, Murray-Brown W, Willis A, Brokstad KA, Sutcliffe N, Piper K, Jonsson R et al. ( 2014 ) . Implication of Epstein-Barr virus infection in disease-specific autoreactive B cell activation in ectopic lymphoid structures of Sjögren's syndrome . Arthritis Rheumatol vol. 66 , ( 9 ) 2545 - 2557 .

Pitzalis C ( 2014 ) . Pathogenesis of rheumatoid arthritis: from systemic autoimmunity to localised joint disease . Drug Discov Today vol. 19 , ( 8 ) 1152 - 1154 .

Corsiero E, Pitzalis C, Bombardieri M ( 2014 ) . Peripheral and synovial mechanisms of humoral autoimmunity in rheumatoid arthritis . Drug Discov Today vol. 19 , ( 8 ) 1161 - 1165 .

Ahmed TJ, Kaneva MK, Pitzalis C, Cooper D, Perretti M ( 2014 ) . Resolution of inflammation: examples of peptidergic players and pathways . Drug Discov Today vol. 19 , ( 8 ) 1166 - 1171 .

Pitzalis C, Jones GW, Bombardieri M, Jones SA ( 2014 ) . Ectopic lymphoid-like structures in infection, cancer and autoimmunity . Nat Rev Immunol vol. 14 , ( 7 ) 447 - 462 .

Lendrem D, Mitchell S, McMeekin P, Bowman S, Price E, T Pease C, Emery P, Andrews J et al. ( 2014 ) . Health-related utility values of patients with primary Sjögren's syndrome and its predictors . Annals of the Rheumatic Diseases vol. 73 , ( 7 ) 1362 - 1368 .

Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Hands R, Rocher V, Bombardieri M et al. ( 2014 ) . AB0132 Presence of Synovial Lymphocyte Aggregates Correlates with A More Severe Clinical Phenotype in Patients with Early Inflammatory Arthritis . Annals of the Rheumatic Diseases . vol. 73 ,

Di Cicco M, Humby FC, Kelly S, Ng N, Mahto A, Hands R, Rocher V, Zou L et al. ( 2014 ) . FRI0020 Presence of Synovial Lymphocyte Aggregates Predicts Clinical Response to DMARD Therapy in Patients with Early Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 73 ,

Lazarou I, Zou L, Mahto A, Di Cicco M, Ng N, Humby F, Pitzalis C, Kelly S ( 2014 ) . FRI0243 Ultrasound-Guided Synovial Biopsy Does not Alter Subsequent Ultrasound Assessments . Annals of the Rheumatic Diseases . vol. 73 ,

Mahto A, Humby F, Ng N, DiCicco M, Rocher V, Lazarou I, Hands R, Gregoriadou S et al. ( 2014 ) . OP0032 Baseline Synovial B-Cell Status Predicts Response to Rituximab Therapy in RA . Annals of the Rheumatic Diseases . vol. 73 ,

Ng N, Kelly S, Humby F, DiCicco M, Rocher V, Hands R, Bombardieri M, Pitzalis C ( 2014 ) . OP0054 Ultrasound Synovitis Reflects Synovial Inflammation at A Histopathological Level . Annals of the Rheumatic Diseases . vol. 73 ,

Corsiero E, Carlotti E, Pratesi F, Wardemann H, Robinson W, Migliorini P, Pitzalis C, Bombardieri M ( 2014 ) . OP0266 Monoclonal Antibodies Derived from Single CD19+ Synovial B Cells of RA Patients with Tertiary Lymphoid Structures Display Preferential Immunoreactivity towards Citrullinated Proteins of Nets . Annals of the Rheumatic Diseases . vol. 73 ,

Di Cicco M, Kelly S, Humby F, Ng N, Nerviani A, Rocher V, Hands R, Bombardieri M et al. ( 2014 ) . SAT0048 Synovial Lymphocytic Aggregates Predict Clinical Response to Certolizumab Pegol in Rheumatoid Arthritis (Clinical and Pathological Response to Certolizumab-Pegol (Clip-Cert) Study) . Annals of the Rheumatic Diseases . vol. 73 ,

Astorri E, Tappuni A, Sutcliffe N, Richards P, Pitzalis C, Bombardieri M ( 2014 ) . THU0008 A Negative High-Resolution Salivary Gland Ultrasound is Highly Predictive of Negative Labial Gland Biopsy in Patients with SICCA Symptoms . Annals of the Rheumatic Diseases . vol. 73 ,

Juarez M, Toms TE, de Pablo P, Mitchell S, Bowman S, Nightingale P, Price EJ, Griffiths B et al. ( 2014 ) . Cardiovascular Risk Factors in Women With Primary Sjögren's Syndrome: United Kingdom Primary Sjögren's Syndrome Registry Results . Arthritis Care & Research vol. 66 , ( 5 ) 757 - 764 .

Di Cicco M, Kelly S, Humby F, Ng N, Hands RE, Rocher V, Nerviani A, Zou L et al. ( 2014 ) . 101. Synovial Ectopic Lymphoneogenesis Predicts Primary Clinical Response to Certolizumab Pegol in Patients with Rheumatoid Arthritis . Rheumatology vol. 53 , ( suppl_1 ) i95 - i95 .

Mahto A, Ng N, DiCicco M, Rocher V, Hands R, Kelly S, Humby F, Pitzalis C ( 2014 ) . 107. Synovial B-Cells Predict Response/Resistance to Rituximab Therapy in Rheumatoid Arthritis: Preliminary Results from a Pilot Study . Rheumatology vol. 53 , ( suppl_1 ) i98 - i98 .

Ng N, Humby F, Di Cicco M, Deidda S, Mahto A, Pyne D, Kidd B, Bombardieri M et al. ( 2014 ) . 124. Ultrasound-Guided Diagnostic Synovial Biopsies: An Audit of a Rheumatology-Led Service . Rheumatology vol. 53 , ( suppl_1 ) i105 - i106 .

Al-Mousawi AZ, Shikh MEME, Pitzalis C ( 2014 ) . 76. Immune Complex Retention by Synovial Fibroblasts in Rheumatoid Arthritis . Rheumatology vol. 53 , ( suppl_1 ) i84 - i84 .

Pitzalis C ( 2014 ) . I104. From the Disease Tissue to the Whole Patient: The Role of Pathobiology in Patient Stratification . Rheumatology vol. 53 , ( suppl_1 ) i22 - i23 .

Ng N, Kelly S, Humby F, Di Cicco M, Rocher V, Hands RE, Bombardieri M, Pitzalis C ( 2014 ) . O37. Ultrasound Measures of Synovitis Reflects Histological Synovial Inflammation in Early Arthritis Patients . Rheumatology vol. 53 , ( suppl_1 ) i45 - i45 .

Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Hands RE, Rocher V, Buckley C et al. ( 2014 ) . O44. Presence of Synovial Lymphocyte Aggregates Correlates with a More Severe Clinical Phenotype in Patients with Early Inflammatory Arthritis . Rheumatology vol. 53 , ( suppl_1 ) i48 - i48 .

Headland S, Norling L, Patel H, Dalli J, Kelly S, Pitzalis C, Dell'Accio F, Perretti M ( 2014 ) . A novel mechanism for protecting the arthritic joint: microparticles deliver Annexin A1 into cartilage (146.8) . The FASEB Journal . vol. 28 ,

Lucchesi D, Pitzalis C, Bombardieri M ( 2014 ) . EBV and other viruses as triggers of tertiary lymphoid structures in primary Sjögren's syndrome . Expert Rev Clin Immunol vol. 10 , ( 4 ) 445 - 455 .

Kam NW, Brentano F, Kyburz D, Gay S, Filer A, Buckley C, Pitzalis C, Bombardieri M ( 2014 ) . A1.12 Endogenous SLPI released by rheumatoid synovial fibroblasts control BAFF-dependent-B cell activation in vitro and in the CIA and RA/SCID-arthritis models . Annals of the Rheumatic Diseases vol. 73 , ( Suppl 1 )

Corsiero E, Carlotti E, Wardemann H, Robinson W, Migliorini P, Pratesi F, Pitzalis C, Bombardieri M ( 2014 ) . A1.31 Monoclonal antibodies from CD19+ synovial B cells of RA patients with tertiary lymphoid structures display a strong immunoreactivity towards citrullinated histones from neutrophils NETs . Annals of the Rheumatic Diseases . vol. 73 ,

Ferrari M, Onuoha S, Sblattero D, Pitzalis C ( 2014 ) . A1.54 Development of a novel bispecific therapeutic for rheumatoid arthritis . Annals of the Rheumatic Diseases . vol. 73 ,

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2014 ) . AB0022 Accumulation of circulating autoreactive naïve b cells reveal defects of early b cell tolerance checkpoints in patients with sjögren’s syndrome . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2014 ) . AB0044 Analysis of recombinant monoclonal antibodies from single B cells reveals early defects of B cell tolerance checkpoints in patients with sjÖgren’s syndrome . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )

Kam NW, Bombardieri M, Filter A, Buckley C, Pitzalis C ( 2014 ) . AB0099 Aberrant basal and TLR-stimulated expression of TSLP in rheumatoid synovial fibroblasts . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )

Croia C, Bombardieri M, Serafini B, Humby F, Migliorini P, Aloisi F, Pitzalis C ( 2014 ) . AB0155 Anti-VCA and EBNA1 antibodies are produced in the rheumatoid synovium in the presence of ectopic lymphoid structures and correlate with ACPA production . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )

Murray-Brown W, Picarelli G, Vartoukian S, Sutcliffe N, Fortune F, Valesini G, Pitzalis C, Tappuni A et al. ( 2014 ) . AB0222 Monocyte-derived IL-32 expression correlates with the level of inflammation in salivary glands of sjÖgren’s syndrome . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )

Ng N, Humby F, Kelly S, Di Cicco M, Dadoun S, Bombardieri M, Hands R, Rocher V et al. ( 2014 ) . AB0247 Rheumatoid arthritis patient characteristics at different therapeutic timepoints . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Ng N, Di Cicco M, Humby F, Deidda S, Pyne D, Kidd B, Sutcliffe N, Jawad A et al. ( 2014 ) . AB0742 Minimally invasive ultrasound guided synovial biopsy as a clinical diagnostic tool . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Croia C, Serafini B, Tappuni A, Aloisi F, Sutcliffe N, Pitzalis C, Bombardieri M ( 2014 ) . FRI0259 Ectopic lymphoid structures support epstein-barr virus persistence and autoreactive plasma cell infection in sjogren’s syndrome salivary glands . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Ng W-F, Miller A, Bowman S, Price E, Kitas G, Pease C, Emery P, Lanyon P et al. ( 2014 ) . FRI0323 Level of physical activity in primary sjögren’s syndrome and its predictors . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Pitzalis C, Bombardieri M ( 2014 ) . OP0080 Lesional IL-21 Expression Correlates with Functional Germinal Center Formation and T Follicular Helper Cell Infiltration in the Salivary Glands of Sjögren’s Syndrome . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Nayar S, Cloake T, Lane P, Pitzalis C, Coles M, Luther S, Buckley C, Barone F ( 2014 ) . OP0258 IL-22 Regulates Lymphoid Stromal Cell Expansion, Development of Germinal Centers and Humoral Response in Mucosal Ectopic Lymphoneogenesis . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Bombardieri M, Rocher V, Mittereder N, Carlesso G, Herbst R, Sleeman M, Pitzalis C ( 2014 ) . OP0303 Mavrilimumab Reduces Pro-Inflammatory Cytokines and CD68 Positive Macrophages in Synovial Explants from Rheumatoid Arthritis Subjects Engrafted Into SCID/Beige Mice . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Deidda S, Humby F, Kelly S, Di Cicco M, Ng N, Hands R, Bombardieri M, Pitzalis C ( 2014 ) . SAT0014 Synovial Sublining Macrophages: A Sensitive Biomarker for Response to Treatment in Early RA Patients . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Di Cicco M, Dadoun S, Humby F, Kelly S, Ng N, Hands RE, Buckley C, McInnes I et al. ( 2014 ) . THU0087 Synovial Ectopic Lymphoid-like Structures are Associated with Diagnosis of Rheumatoid Arthritis, Disease Activity and Antibody Status in Early Arthritis Patients . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )

Eldridge S, Vicente-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F ( 2014 ) . Agrin expression is downregulated in OA and is required for chondrocyte differentiation . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 95 , A8 - A9 .

Juarez M, Toms TE, de Pablo P, Mitchell S, Bowman S, Nightingale P, Price EJ, Griffiths B et al. ( 2014 ) . Cardiovascular Risk Factors in Women With Primary Sjogren's Syndrome: United Kingdom Primary Sjogren's Syndrome Registry Results . ARTHRITIS CARE & RESEARCH vol. 66 , ( 5 ) 757 - 764 .

Corsiero E, Bombardieri M, Carlotti E, Pratesi F, Robinson W, Migliorini P, Pitzalis C ( 2014 ) . Citrullinated histones from neutrophil extracellular traps (NETs) fuel ectopic germinal centre responses and ACPA production in rheumatoid joints . IMMUNOLOGY vol. 143 , 43 - 43 .

Pitzalis C ( 2014 ) . FROM THE DISEASE TISSUE TO THE WHOLE PATIENT: THE ROLE OF PATHOBIOLOGY IN PATIENT STRATIFICATION . RHEUMATOLOGY . vol. 53 , 22 - 23 .

Haas R, Smith J, Rocher-Ros V, Montero-Melendez T, D'Acquisto F, Bland EJ, Bombardieri M, Pitzalis C et al. ( 2014 ) . How the microenvironment contributes to the establishment of chronic inflammatory diseases: lactate regulates metabolic and pro-inflammatory circuits in control of T cell migration and functions . IMMUNOLOGY vol. 143 , 151 - 151 .

Al-Mousawi AZ, El Shikh MEM, Pitzalis C ( 2014 ) . IMMUNE COMPLEX RETENTION BY SYNOVIAL FIBROBLASTS IN RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 53 , 84 - 84 .

Lucchesi D, Pontarini E, Pitzalis C, Bombardieri M ( 2014 ) . Innate immune system early activation precedes the formation of functional tertiary lymphoid structures in a novel model of salivary gland ectopic lymphoid neogenesis . IMMUNOLOGY vol. 143 , 95 - 95 .

Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Hands RE, Rocher V, Buckley C et al. ( 2014 ) . PRESENCE OF SYNOVIAL LYMPHOCYTE AGGREGATES CORRELATES WITH A MORE SEVERE CLINICAL PHENOTYPE IN PATIENTS WITH EARLY INFLAMMATORY ARTHRITIS . RHEUMATOLOGY . vol. 53 , 48 - 48 .

Mahto A, Ng N, DiCicco M, Rocher V, Hands R, Kelly S, Humby F, Pitzalis C ( 2014 ) . SYNOVIAL B-CELLS PREDICT RESPONSE/RESISTANCE TO RITUXIMAB THERAPY IN RHEUMATOID ARTHRITIS: PRELIMINARY RESULTS FROM A PILOT STUDY . RHEUMATOLOGY . vol. 53 , 98 - 98 .

Di Cicco M, Kelly S, Humby F, Ng N, Hands RE, Rocher V, Nerviani A, Zou L et al. ( 2014 ) . SYNOVIAL ECTOPIC LYMPHONEOGENESIS PREDICTS PRIMARY CLINICAL RESPONSE TO CERTOLIZUMAB PEGOL IN PATIENTS WITH RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 53 , 95 - 95 .

James K, Lendrem D, Mitchell S, Hindmarsh V, Bowman S, Price EJ, Pease CT, Emery P et al. ( 2014 ) . THE UK PRIMARY SJOGREN'S SYNDROME REGISTRY (UKPSSR): A VALUABLE RESOURCE FOR FUTURE SJOGREN'S SYNDROM RESEARCH . RHEUMATOLOGY . vol. 53 , 136 - 136 .

Ahmed TJ, Perretti M, Pitzalis C ( 2014 ) . TRANSLATIONAL MEDICINE IN RHEUMATOID ARTHRITIS: EXPLOITING MELANOCORTIN RECEPTORS . RHEUMATOLOGY . vol. 53 , 85 - 86 .

Brown S, Coy NN, Pitzalis C, Emery P, Pavitt S, Gray J, Hulme C, Hall F et al. ( 2014 ) . The TRACTISS Protocol: a randomised double blind placebo controlled clinical TRial of Anti-B-Cell Therapy In patients with primary Sjogren's Syndrome . BMC MUSCULOSKELETAL DISORDERS vol. 15 , Article ARTN 21 ,

Nalesso G, Thomas B, Wagner K, Bertrand J, Sherwood J, Eldridge S, Pap T, Achan P et al. ( 2014 ) . The WNT/CaMKII pathway is activated in human and experimental osteoarthritis and promotes chondrocyte de-differentiation . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 95 , A25 - A26 .

Ng N, Kelly S, Humby F, Di Cicco M, Rocher V, Hands RE, Bombardieri M, Pitzalis C ( 2014 ) . ULTRASOUND MEASURES OF SYNOVITIS REFLECTS HISTOLOGICAL SYNOVIAL INFLAMMATION IN EARLY ARTHRITIS PATIENTS . RHEUMATOLOGY . vol. 53 , 45 - 45 .

Ng N, Humby F, Di Cicco M, Deidda S, Mahto A, Pyne D, Kidd B, Bombardieri M et al. ( 2014 ) . ULTRASOUND-GUIDED DIAGNOSTIC SYNOVIAL BIOPSIES: AN AUDIT OF A RHEUMATOLOGY-LED SERVICE . RHEUMATOLOGY . vol. 53 , 105 - 106 .

Ng N, Kelly S, Humby F, DiCicco M, Rocher V, Hands R, Bombardieri M, Pitzalis C ( 2014 ) . Ultrasound Synovitis Reflects Synovial Inflammation at a Histopathological Level . ARTHRITIS & RHEUMATOLOGY vol. 66 , S400 - S400 .

Nalesso G, Thomas BL, Sherwood J, Schett G, Dale L, Addimanda O, Eltawil N, Pitzalis C et al. ( 2014 ) . WNT16 IS INDUCED BY OXIDATIVE STRESS FOLLOWING CARTILAGE INJURY AND CONTRIBUTES TO CARTILAGE HOMEOSTASIS IN OSTEOARTHRITIS . OSTEOARTHRITIS AND CARTILAGE . vol. 22 , S8 - S9 .

Thomas BL, Nalesso G, Sherwood J, Bertrand J, Achan P, Pitzalis C, Dell'Accio F ( 2014 ) . WNT16 SUPPORTS THE PHENOTYPE OF THE SUPERFICIAL ZONE CELLS IN CARTILAGE . OSTEOARTHRITIS AND CARTILAGE . vol. 22 , S160 - S160 .

El Shikh ME, Kmieciak M, Manjili MH, Szakal AK, Pitzalis C, Tew JG ( 2013 ) . Multi-therapeutic potential of autoantibodies induced by immune complexes trapped on follicular dendritic cells . Hum Vaccin Immunother vol. 9 , ( 11 ) 2434 - 2444 .

Nordmark G, Wang C, Vasaitis L, Eriksson P, Theander E, Kvarnström M, Forsblad‐d'Elia H, Jazebi H et al. ( 2013 ) . Association of Genes in the NF‐κB Pathway with Antibody‐Positive Primary Sjögren's Syndrome . Scandinavian Journal of Immunology vol. 78 , ( 5 ) 447 - 454 .

Croia C, Serafini B, Bombardieri M, Kelly S, Humby F, Severa M, Rizzo F, Coccia EM et al. ( 2013 ) . Epstein-Barr virus persistence and infection of autoreactive plasma cells in synovial lymphoid structures in rheumatoid arthritis . Ann Rheum Dis vol. 72 , ( 9 ) 1559 - 1568 .

Lendrem D, Mitchell S, McMeekin P, Bowman S, Price E, Pease CT, Emery P, Andrews J et al. ( 2013 ) . Health-related utility values of patients with primary Sjögren's syndrome and its predictors . Annals of the Rheumatic Diseases

Pitzalis C, Kelly S, Humby F ( 2013 ) . New learnings on the pathophysiology of RA from synovial biopsies . Curr Opin Rheumatol vol. 25 , ( 3 ) 334 - 344 .

Eldridge S, Vicent-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F ( 2013 ) . Agrin expression is downregulated in OA and is required for chondrocyte differentiation . Osteoarthritis and Cartilage vol. 21 , s112 - s113 .

Tarn J, Natasari A, Mitchell S, Bowman S, Price E, Pease C, Emery P, Andrews J et al. ( 2013 ) . Soluble molecule profiling and network analysis of primary Sjögren's Syndrome patient serum . BMC Musculoskeletal Disorders vol. 14 , ( Suppl 1 )

Pitzalis C ( 2013 ) . "HUMAN SCID CHIMERAS: MODELS TO DISSECT AUTOIMMUNITY AND INFLAMMATION" . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , 40 - 40 .

Sherwood J, Nalesso G, Bertrand J, Achan P, Brandolini L, Pap T, Pitzalis C, Dell'Accio F ( 2013 ) . A NOVEL ROLE FOR ELR plus CXC CHEMOKINE SIGNALING IN CARTILAGE HOMEOSTASIS . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , 161 - 161 .

Sherwood J, Nalesso G, Bertrand J, Brandolini L, Achan P, Pitzalis C, Pap T, Dell'Accio F ( 2013 ) . A homoeostatic role for ELR plus CXC chemokine signalling in articular and epiphyseal cartilage . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 94 , A7 - A8 .

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEAL DEFECTS OF EARLY B CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 792 - 792 .

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEALS DEFECTS OF EARLY B-CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME . RHEUMATOLOGY . vol. 52 , 159 - 159 .

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . Accumulation of Circulating Autoreactive Naive B Cells Reveal Defects of Early B Cell Tolerance Checkpoints in Patients with Sjogren's Syndrome . ANNALS OF THE RHEUMATIC DISEASES . vol. 72 , A30 - A31 .

Patel HB, Bombardieri M, Pitzalis C, Perretti M ( 2013 ) . Activation of Melanocortin Receptor 3 as a new strategy to control experimental and rheumatoid arthritis . FASEB JOURNAL . vol. 27 ,

Ng N, Humby F, Bombardieri M, Kelly S, Di Cicco M, Dadoun S, Hands R, Rocher V et al. ( 2013 ) . CLINICAL, IMAGING AND HISTOLOGICAL CHARACTERISTICS OF PATIENTS WITH RHEUMATOID ARTHRITIS AT DIFFERENT STAGES OF DISEASE PROGRESSION . RHEUMATOLOGY . vol. 52 , 71 - 71 .

Ahmed TJ, Montero-Melendez T, Perretti M, Pitzalis C ( 2013 ) . Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides . Int J Inflam vol. 2013 ,

Ferrari M, Onuoha S, Kamalati T, Sblattero D, Pitzalis C ( 2013 ) . Development Of a Novel Bispecific Therapeutic For Arthritic Diseases . ARTHRITIS AND RHEUMATISM . vol. 65 , S218 - S218 .

Croia C, Serafini B, Tappuni A, Aloisi F, Sutcliffe N, Pitzalis C, Bombardieri M ( 2013 ) . ECTOPIC LYMPHOID STRUCTURES SUPPORT EPSTEIN-BARR VIRUS PERSISTENCE AND AUTOREACTIVE PLASMA CELL INFECTION IN SJOGREN'S SYNDROME SALIVARY GLANDS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 462 - 462 .

Ng W-F, Lendrem D, Mitchell S, Bowman S, Price E, Pease C, Emery P, Andrews J et al. ( 2013 ) . EVALUATING HEALTH STATUS OF 620 PATIENTS WITH PRIMARY SJOGREN'S SYNDROME USING EQ-5D . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , 466 - 466 .

Ng W-F, Mitchell S, Lendrem D, Bowman S, Price E, Pease C, Emery P, Andrews J et al. ( 2013 ) . HOW GOOD ARE THE EULAR SJOGREN'S SYNDROME DISEASE ACTIVITY INDEX (ESSDAI), AND EULAR SJOGREN'S SYNDROME PATIENTS REPORTED INDEX (ESSPRI) IN PREDICTING HEALTH STATUS IN PRIMARY SJOGREN'S SYNDROME? . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , 553 - 554 .

Nayar S, Cloake T, Lane P, Pitzalis C, Coles M, Luther S, Buckley C, Barone F ( 2013 ) . IL-22 REGULATES LYMPHOID STROMAL CELL EXPANSION, DEVELOPMENT OF GERMINAL CENTERS AND HUMORAL RESPONSE IN MUCOSAL ECTOPIC LYMPHONEOGENESIS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 140 - 140 .

Lucchesi D, Bombardieri M, Barone F, Nayar S, Proctor G, Buckley CD, Pitzalis C ( 2013 ) . INDUCIBLE TERTIARY LYMPHOID STRUCTURES AND AUTOIMMUNITY IN A NOVEL MODEL OF SIALOADENITIS IN WILD-TYPE MICE . ANNALS OF THE RHEUMATIC DISEASES . vol. 72 , A42 - A42 .

Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Rocher V, Williams AS, Pitzalis C, Jenkins BJ et al. ( 2013 ) . Interleukin-27 as a novel antagonist of ectopic lymphoid-like structure development in early inflammatory arthritis . CYTOKINE . vol. 63 , 274 - 274 .

Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Pitzalis C, Bombardieri M ( 2013 ) . LESIONAL IL-21 EXPRESSION CORRELATES WITH FUNCTIONAL GERMINAL CENTER FORMATION AND T FOLLICULAR HELPER CELL INFILTRATION IN THE SALIVARY GLANDS OF SJOGREN'S SYNDROME . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 77 - 77 .

Ng W-F, Miller A, Bowman S, Price E, Kitas G, Pease C, Emery P, Lanyon P et al. ( 2013 ) . LEVEL OF PHYSICAL ACTIVITY IN PRIMARY SJOGREN'S SYNDROME AND ITS PREDICTORS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 483 - 484 .

Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Pitzalis C, Bombardieri M ( 2013 ) . Lesional Intereukin-21 Expression Correlates With Functional Germinal Center Formation and T Follicular Helper Cell Infiltration In The Salivary Glands Of Sjogren's Syndrome . ARTHRITIS AND RHEUMATISM . vol. 65 , S634 - S634 .

Bombardieri M, Rocher V, Mittereder N, Carlesso G, Herbst R, Sleeman M, Pitzalis C ( 2013 ) . MAVRILIMUMAB REDUCES PRO-INFLAMMATORY CYTOKINES AND CD68 POSITIVE MACROPHAGES IN SYNOVIAL EXPLANTS FROM RHEUMATOID ARTHRITIS SUBJECTS ENGRAFTED INTO SCID/BEIGE MICE . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 156 - 157 .

Kam NW, Filer A, Buckley C, Bombardieri M, Pitzalis C ( 2013 ) . MEMBRANE-BOUND AND SOLUBLE BAFF EXPRESSION BY HUMAN RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTES IN RESPONSE TO TLR STIMULATION . ANNALS OF THE RHEUMATIC DISEASES . vol. 72 , A38 - A38 .

Ng N, Di Cicco M, Humby F, Deidda S, Pyne D, Kidd B, Sutcliffe N, Jawad A et al. ( 2013 ) . MINIMALLY INVASIVE ULTRASOUND GUIDED SYNOVIAL BIOPSY AS A CLINICAL DIAGNOSTIC TOOL . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 1015 - 1016 .

El Shikh ME, Biggioggero M, El Sayed R, Kmieciak M, Manjili M, Szakal A, Meroni PL, Pitzalis C et al. ( 2013 ) . REGULATION OF AUTO-ANTIBODY PRODUCTION BY AUTO-IMMUNE COMPLEXES ON FOLLICULAR DENDRITIC CELLS . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , 129 - 129 .

Ng N, Humby F, Kelly S, Di Cicco M, Dadoun S, Bombardieri M, Hands R, Rocher V et al. ( 2013 ) . RHEUMATOID ARTHRITIS PATIENT CHARACTERISTICS AT DIFFERENT THERAPEUTIC TIMEPOINTS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 862 - 862 .

Corsiero E, Bombardieri M, Carlotti E, Wardemann H, Robinson WH, Pitzalis C ( 2013 ) . Recombinant Monoclonal Antibodies Derived From Single CD19+Synovial B Cells Of RA Patients With Tertiary Lymphoid Structures Display a Strong Immunoreactivity Towards Citrullinated Histones . ARTHRITIS AND RHEUMATISM . vol. 65 , S1127 - S1128 .

Tarn J, Mitchell S, Bowman S, Price E, Pease C, Sutcliffe N, Emery P, Andrews J et al. ( 2013 ) . SERUM CYTOKINE AND CHEMOKINE PROFILING IN PRIMARY SJOGREN'S SYNDROME . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , 527 - 528 .

Di Cicco M, Dadoun S, Humby F, Kelly S, Ng N, Hands RE, Buckley C, McInnes I et al. ( 2013 ) . SYNOVIAL ECTOPIC LYMPHOID-LIKE STRUCTURES ARE ASSOCIATED WITH DIAGNOSIS OF RHEUMATOID ARTHRITIS, DISEASE ACTIVITY AND ANTIBODY STATUS IN EARLY ARTHRITIS PATIENTS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 192 - 192 .

Di Cicco M, Humby F, Kelly S, Ng N, Hands R, Dadoun S, Buckley C, McInnes IB et al. ( 2013 ) . SYNOVIAL LYMPHOCYTE AGGREGATES IN EARLY INFLAMMATORY ARTHRITIS: CORRELATION WITH DIAGNOSIS, DISEASE ACTIVITY AND ANTIBODY STATUS . RHEUMATOLOGY . vol. 52 , 29 - 29 .

Croia C, Serafini B, Bombardieri M, Kelly S, Humby F, Severa M, Rizzo F, Coccia EM et al. ( 2013 ) . SYNOVIAL LYMPHOID STRUCTURES SUPPORT EPSTEIN-BARR VIRUS PERSISTENCE AND AUTOREACTIVE PLASMA CELL INFECTION IN RHEUMATOID ARTHRITIS . ANNALS OF THE RHEUMATIC DISEASES . vol. 72 , A43 - A44 .

Deidda S, Humby F, Kelly S, Di Cicco M, Ng N, Hands R, Bombardieri M, Pitzalis C ( 2013 ) . SYNOVIAL SUBLINING MACROPHAGES: A SENSITIVE BIOMARKER FOR RESPONSE TO TREATMENT IN EARLY RA PATIENTS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 583 - 584 .

Kam YNW, Filer A, Buckley CD, Pitzalis C, Bombardieri M ( 2013 ) . Secretory Leukocyte Protease Inhibitor Released By Rheumatoid Synovial Fibroblasts Exerts a Negative Control Of BAFF-Dependent B Cell Activation In Vitro and In Vivo In The Collagen-Induced and Chimeric RA/SCID Arthritis Models . ARTHRITIS AND RHEUMATISM . vol. 65 , S1029 - S1029 .

Di Cicco M, Kelly S, Humby F, Ng N, Dadoun S, Hands R, Rocher V, Nerviani A et al. ( 2013 ) . Synovial Ectopic Lymphoneogenesis Predicts Clinical Response To Certolizumab Pegol In Patients With Rheumatoid Arthritis . ARTHRITIS AND RHEUMATISM . vol. 65 , S556 - S556 .

Sherwood J, Bertrand J, Nalesso G, Achan P, Pitzalis C, Pap T, Dell'Accio F ( 2013 ) . THE ROLE OF CXCR2 SIGNALING IN ARTICULAR CARTILAGE HOMEOSTASIS . OSTEOARTHRITIS AND CARTILAGE . vol. 21 , S19 - S20 .

Sherwood J, Bertrand J, Nalesso G, Achan P, Pitzalis C, Pap T, Dell'Accio F ( 2013 ) . THE ROLE OF CXCR2 SIGNALLING IN ARTICULAR CARTILAGE HOMEOSTASIS . ANNALS OF THE RHEUMATIC DISEASES . vol. 72 , A63 - A64 .

Wythe SE, DiCara D, Taher TEI, Finucane CM, Jones R, Bombardieri M, Man YKS, Nissim A et al. ( 2013 ) . Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide . Ann Rheum Dis vol. 72 , ( 1 ) 129 - 135 .

Nalesso G, Thomas BL, Eldridge SE, Wagner K, Sherwood J, Bertrand J, Pap T, Pitzalis C et al. ( 2013 ) . WNT5A/CAMKII PATHWAY IS ACTIVATED IN OSTEOARTHRITIS AND PROMOTES LOSS OF CHONDROCYTE PHENOTYPE . OSTEOARTHRITIS AND CARTILAGE . vol. 21 , S226 - S226 .

Patel HB, Kornerup KN, Sampaio ALF, D'Acquisto F, Seed MP, Girol AP, Gray M, Pitzalis C et al. ( 2012 ) . The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis . Ann Rheum Dis vol. 71 , ( 11 ) 1872 - 1880 .

Bombardieri M, Barone F, Lucchesi D, Nayar S, van den Berg WB, Proctor G, Buckley CD, Pitzalis C ( 2012 ) . Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of salivary gland inflammation in C57BL/6 mice . J Immunol vol. 189 , ( 7 ) 3767 - 3776 .

Bombardieri M, Pitzalis C ( 2012 ) . Ectopic lymphoid neogenesis and lymphoid chemokines in Sjogren's syndrome: at the interplay between chronic inflammation, autoimmunity and lymphomagenesis . Curr Pharm Biotechnol vol. 13 , ( 10 ) 1989 - 1996 .

Corsiero E, Bombardieri M, Manzo A, Bugatti S, Uguccioni M, Pitzalis C ( 2012 ) . Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases . Immunol Lett vol. 145 , ( 1-2 ) 62 - 67 .

Patel HB, Kornerup KN, Sampaio ALFS, D'Acquisto F, Seed MP, Girol AP, Gray M, Pitzalis C et al. ( 2012 ) . The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis . Annals of the Rheumatic Diseases

Whitehead MA, Bombardieri M, Pitzalis C, Vanhaesebroeck B ( 2012 ) . Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter . Biochem J vol. 443 , ( 3 ) 857 - 867 .

De Bari C, Pitzalis C, Dell'Accio F ( 2012 ) . Joint Tissue Engineering . Stem Cell Repair and Regeneration , World Scientific Publishing

Pitzalis C ( 2012 ) . ADVANCES IN PATHOGENESIS: THE RHEUMATOLOGY VIEW: WHAT BIOLOGICAL PROCESSES DRIVE DIFFERENT DISEASE EXPRESSIONS IN PSA? . RHEUMATOLOGY . vol. 51 , 15 - 15 .

Croia C, Bombardieri M, Francesca A, Serafini B, Humby F, Kelly S, Migliorini P, Pitzalis C ( 2012 ) . ANTI-VCA AND EBNA1 ANTIBODIES ARE PRODUCED IN THE RHEUMATOID SYNOVIUM IN THE PRESENCE OF ECTOPIC LYMPHOID STRUCTURES AND CORRELATE WITH ACPA PRODUCTION . RHEUMATOLOGY . vol. 51 , 43 - 43 .

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2012 ) . Accumulation of circulating autoreactive naive B cells reveal defects of early B cell tolerance checkpoints in patients with Sjogren's syndrome . IMMUNOLOGY . vol. 137 , 327 - 327 .

Newton JL, Frith J, Powell D, Hackett K, Wilton K, Bowman S, Price E, Pease C et al. ( 2012 ) . Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjogren's syndrome . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , ( 12 ) 1973 - 1979 .

Coates LC, Aslam T, Burden AD, Burden-Teh E, Caperon AR, Cerio R, Chattopadhyay C, Chinoy H et al. ( 2012 ) . Comparison of Three Screening Tools in Psoriatic Arthritis: The Contest Study . ARTHRITIS AND RHEUMATISM . vol. 64 , S580 - S580 .

Ferrari M, Kamalati T, Pitzalis C ( 2012 ) . DEVELOPMENT OF A NOVEL RECOMBINANT BIOTHERAPEUTIC WITH APPLICATIONS IN TARGETED THERAPY OF HUMAN ARTHRITIS . RHEUMATOLOGY . vol. 51 , 123 - 123 .

Nayar S, Cloake T, Bombardieri M, Pitzalis C, Buckley C, Barone F ( 2012 ) . ECTOPIC LYMPHONEOGENESIS IN A NOVEL MURINE MODEL OF SALIVARY GLANDS SIALOADENITIS IS CHARACTERIZED BY ASYNCHRONY IN THE LYMPHANGIOGENETIC AND ANGIOGENETIC PROGRAM . RHEUMATOLOGY . vol. 51 , 143 - 144 .

Sherwood J, Nalesso G, Bertrand J, Pap T, Achan P, Pitzalis C, Dell'Accio F ( 2012 ) . ELR plus CXC CHEMOKINE SIGNALLING IN ARTICULAR CHONDROCYTE PHENOTYPIC STABILITY . ANNALS OF THE RHEUMATIC DISEASES . vol. 71 , A63 - U350 .

Sherwood J, Nalesso G, Bertrand J, Achan P, Brandolini L, Pap T, Pitzalis C, Dell'Accio F ( 2012 ) . ELR plus CXC CHEMOKINE SIGNALLING IN CARTILAGE HOMEOSTASIS . OSTEOARTHRITIS AND CARTILAGE . vol. 20 , S116 - S116 .

Sherwood J, Nalesso G, Bertrand J, Pap T, Achan P, Pitzalis C, Dell'Accio F ( 2012 ) . ELR plus CXC chemokine signaling is required for phenotypic stability of human articular chondrocytes . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 93 , A6 - A7 .

Lendrem D, Mitchell S, Bowman S, Price E, Pease CT, Emery P, Andrews J, Bombardieri M et al. ( 2012 ) . EVALUATING HEALTH STATUS OF 620 PATIENTS WITH PRIMARY SJOGREN'S SYNDROME USING EQ-5D . RHEUMATOLOGY . vol. 51 , 171 - 171 .

Scheinberg M, Filippi RZ, Hands R, Pitzalis C ( 2012 ) . Failure to Control Progression of Rheumatoid Arthritis After a Decade of Biologic Therapy . JOURNAL OF RHEUMATOLOGY vol. 39 , ( 10 ) 2049 - 2051 .

EL SHIKH ME, PITZALIS C ( 2012 ) . Follicular dendritic cells in health and disease . Frontiers in Immunology

Lendrem D, Mitchell S, Bowman S, Price E, Pease CT, Emery P, Andrews J, Bombardieri M et al. ( 2012 ) . HOW GOOD ARE THE EULAR SJOGREN'S SYNDROME DISEASE ACTIVITY INDEX, AND EULAR SJOGREN'S SYNDROME PATIENTS REPORTED INDEX IN PREDICTING HEALTH STATUS IN PRIMARY SJOGREN'S SYNDROME? . RHEUMATOLOGY . vol. 51 , 176 - 176 .

Jones GW, Greenhill CJ, Williams AS, Nowell MA, Bombardieri M, Pitzalis C, Jenkins BJ, Jones SA ( 2012 ) . IL-27 control of ectopic lymphoid structures in inflammatory arthritis . IMMUNOLOGY . vol. 137 , 44 - 44 .

Lucchesi D, Bombardieri M, Barone F, Nayar S, Proctor G, Buckley CD, Pitzalis C ( 2012 ) . Inducible tertiary lymphoid structures formation in a novel model of sialoadenitis in wild-type mice is preceded by ectopic expression of lymphoid chemokines . IMMUNOLOGY . vol. 137 , 189 - 189 .

Pitzalis C, Veale D, Dayer J-M ( 2012 ) . Introduction to "Synovitis--an inflammation of joints destroying the bone" . Swiss Med Wkly vol. 142 ,

Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Pitzalis C, Bombardieri M ( 2012 ) . Lesional IL-21 expression correlates with functional germinal center formation and T follicular helper cell infiltration in the salivary glands of Sjogren's syndrome . IMMUNOLOGY . vol. 137 , 491 - 491 .

Nayar S, Chung MM, Rankin P, Cloake T, Pitzalis C, Lane P, Buckley C, Barone F ( 2012 ) . Lymphotoxin beta regulates lymphatic vessel expansion in mucosal ectopic lymphoneogenesis . IMMUNOLOGY . vol. 137 , 430 - 430 .

Murray-Brown W, Priori R, Tappuni T, Vartoukian S, Seoudi N, Picarelli G, Fortune F, Valesini G et al. ( 2012 ) . MONOCYTE-DERIVED IL-32 EXPRESSION CORRELATES WITH THE LEVEL OF INFLAMMATION IN SALIVARY GLANDS OF SJOGREN'S SYNDROME . RHEUMATOLOGY . vol. 51 , 176 - 176 .

Kam NW, Filer A, Buckley C, Bombardieri M, Pitzalis C ( 2012 ) . Membrane-bound and soluble BAFF expression by human rheumatoid fibroblast-like synoviocytes in response to TLR stimulation . IMMUNOLOGY . vol. 137 , 583 - 584 .

El Shikh MEM, Biggioggero M, El Sayed RM, Kmieciak M, Manjili MH, Szakal AK, Meroni PL, Pitzalis C et al. ( 2012 ) . REGULATION OF AUTO-ANTIBODY PRODUCTION BY PERSISTING AUTO-IMMUNE COMPLEXES ON FOLLICULAR DENDRITIC CELLS . ANNALS OF THE RHEUMATIC DISEASES . vol. 71 , A38 - A38 .

Vila J, Mitchell S, Bowman S, Price E, Pease CT, Emery P, Andrews J, Bombardieri M et al. ( 2012 ) . THE CLINICAL RELEVANCE OF ANTI-RO52 AND ANTI-RO60 IN PATIENTS IN THE UNITED KINGDOM PRIMARY SJOGREN'S SYNDROME REGISTRY (UKPSSR) . RHEUMATOLOGY . vol. 51 , 35 - 35 .

DiCicco M, Humby F, Kelly S, Hands R, Buckley C, McInnes I, Taylor P, Bombardieri M et al. ( 2012 ) . THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT: A PRELIMINARY ANALYSIS CORRELATING HISTOMORPHOLOGY AND DISEASE ACTIVITY . RHEUMATOLOGY . vol. 51 , 149 - 149 .

Macor P, Durigutto P, De Maso L, Garrovo C, Biffi S, Cortini A, Fischetti F, Sblattero D et al. ( 2012 ) . Treatment of experimental arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5 . ARTHRITIS AND RHEUMATISM vol. 64 , ( 8 ) 2559 - 2567 .

Kelly S, Bombardieri M, Humby F, Ng N, Di Cicco M, Hands R, Epis O, Filer A et al. ( 2012 ) . ULTRASOUND GUIDED SYNOVIAL BIOPSIES: SAFETY, TOLERABILITY, AND TISSUE QUALITY . RHEUMATOLOGY . vol. 51 , 68 - 68 .

Seymour MW, Kelly S, Beals CR, Malice M-P, Bolognese JA, Dardzinski BJ, Cheng AS, Cummings CE et al. ( 2012 ) . Ultrasound of metacarpophalangeal joints is a sensitive and reliable endpoint for drug therapies in rheumatoid arthritis: results of a randomized, two-center placebo-controlled study . ARTHRITIS RESEARCH & THERAPY vol. 14 , ( 5 ) Article ARTN R198 ,

Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, Dell'Accio F ( 2012 ) . WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 93 , A8 - A8 .

Kamperidis P, Kamalati T, Ferrari M, Jones M, Garrood T, Smith MD, Diez-Posada S, Hughes C et al. ( 2011 ) . Development of a novel recombinant biotherapeutic with applications in targeted therapy of human arthritis . Arthritis Rheum vol. 63 , ( 12 ) 3758 - 3767 .

Bombardieri M, Kam N-W, Brentano F, Choi K, Filer A, Kyburz D, McInnes IB, Gay S et al. ( 2011 ) . A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells . Ann Rheum Dis vol. 70 , ( 10 ) 1857 - 1865 .

Miossec P, Verweij CL, Klareskog L, Pitzalis C, Barton A, Lekkerkerker F, Reiter S, Laslop A et al. ( 2011 ) . Biomarkers and personalised medicine in rheumatoid arthritis: a proposal for interactions between academia, industry and regulatory bodies . ANN RHEUM DIS vol. 70 , ( 10 ) 1713 - 1718 .

Ingegnoli F, Blades M, Manzo A, Wahid S, Perretti M, Panayi G, Pitzalis C ( 2011 ) . Role of cell migration in the pathogenesis of rheumatoid arthritis: in vivo studies in SCID mice transplanted with human synovial membrane . Reumatismo vol. 54 , ( 2 ) 128 - 132 .

Ingegnoli F, Manzo A, Fantini F, Caporali R, Montecucco C, Pipitone N, Pitzalis C ( 2011 ) . Role of chemokines in the pathogenesis of rheumatoid synovitis . Reumatismo vol. 54 , ( 1 ) 12 - 18 .

de Hair MJH, Harty LC, Gerlag DM, Pitzalis C, Veale DJ, Tak PP ( 2011 ) . Synovial Tissue Analysis for the Discovery of Diagnostic and Prognostic Biomarkers in Patients with Early Arthritis . J RHEUMATOL vol. 38 , ( 9 ) 2068 - 2072 .

Macor P, Durigutto P, De Maso L, Fischetti F, Cortini A, Edomi P, Pitzalis C, Tedesco F ( 2011 ) . Treatment of antigen-induced and collagen-induced arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5 . MOLECULAR IMMUNOLOGY . vol. 48 , 1676 - 1676 .

Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, Dell'accio F ( 2011 ) . WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways . J Cell Biol vol. 193 , ( 3 ) 551 - 564 .

El Shikh ME, El Sayed R, Kmieciak M, Manjili M, Szakal A, Pitzalis C, Tew J ( 2011 ) . BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS . RHEUMATOLOGY . vol. 50 , 51 - 51 .

Pitzalis C ( 2011 ) . CAN PATHOBIOLOGY INFORM DISEASE OUTCOME AND RESPONSE TO THERAPY? . RHEUMATOLOGY . vol. 50 , 22 - 22 .

Marrelli A, Bombardieri M, Kelly S, Cipriani P, Giacomelli R, Pitzalis C ( 2011 ) . DIGITAL IMAGE ANALYSIS FOR THE EVALUATION OF BLOOD VESSEL DENSITY IN RHEUMATOID SYNOVIUM: CORRELATION WITH QUANTITATIVE REAL-TIME PCR EXPRESSION OF ENDOTHELIAL ANTIGEN AND ANGIOGENIC GROWTH FACTORS . RHEUMATOLOGY . vol. 50 , 75 - 75 .

Croia C, Serafini B, Bombardieri M, Kelly S, Coccia EM, Severa M, Francesca A, Pitzalis C ( 2011 ) . EBV INFECTION IN THE RHEUMATOID ARTHRITIS SYNOVIUM: RELATIONSHIP TO ECTOPIC LYMPHOID STRUCTURES AND CD8 T CELL ACTIVATION . RHEUMATOLOGY . vol. 50 , 75 - 75 .

Astorri E, Bombardi M, Peakman M, Pozzilli P, Pitzalis C ( 2011 ) . EVOLUTION OF ECTOPIC LYMPHOID NEOGENESIS AND IN SITU AUTOANTIBODY PRODUCTION IN AUTOIMMUNE DIABETIC NOD MICE: CELLULAR AND MOLECULAR CHARACTERIZATION OF TERTIARY LYMPHOID STRUCTURES IN PANCREATIC ISLETS . RHEUMATOLOGY . vol. 50 , 52 - 53 .

Priori R, Barone F, Alessandri C, Colafrancesco S, McInnes IB, Pitzalis C, Valesini G, Bombardieri M ( 2011 ) . Markedly increased IL-18 liver expression in adult-onset Still's disease-related hepatitis . Rheumatology (Oxford) vol. 50 , ( 4 ) 776 - 780 .

Mahoney DJ, Swales C, Athanasou NA, Bombardieri M, Pitzalis C, Kliskey K, Sharif M, Day AJ et al. ( 2011 ) . TSG-6 Inhibits Osteoclast Activity via an Autocrine Mechanism and Is Functionally Synergistic With Osteoprotegerin . ARTHRITIS RHEUM-US vol. 63 , ( 4 ) 1034 - 1043 .

Nalesso G, Sherwood J, Ramachandran M, De Bari C, Pitzalis C, Dell'Accio F ( 2011 ) . Biology of bone, cartilage and connectve tissue disease . Rheumatology vol. 50 , ( suppl_3 ) iii77 - iii77 .

Ciurtin C, Majeed Y, Naylor J, Sukumar P, English A, Emery P, Beech D, Malik N et al. ( 2011 ) . Cell receptor-ligand interaction, signalling, activation and apoptosis . Rheumatology vol. 50 , ( suppl_3 ) iii50 - iii52 .

Nesbitt A, Fossati G, Whittall CE, Askari A, Middleton J, Astorri E, Bombardi M, Peakman M et al. ( 2011 ) . Cytokines and inflammatory mediators . Rheumatology vol. 50 , ( suppl_3 ) iii52 - iii55 .

Rajak R, Amos N, Camilleri J, Charles PJ, Plant D, Chowdhury M, Worthington J, Venables P et al. ( 2011 ) . Rheumatoid arthritis - aetiopathogenesis and animal models . Rheumatology vol. 50 , ( suppl_3 ) iii74 - iii76 .

Bugatti S, Manzo A, Vitolo B, Fusetti C, Humby F, Caporali R, Pitzalis C, Montecucco C ( 2011 ) . B CELL DISTRIBUTION AND ACTIVATION-INDUCED CYTIDINE DEAMINASE EXPRESSION IN RHEUMATOID SYNOVITIS: CLINICAL AND BIO-MOLECULAR CORRELATES . ANNALS OF THE RHEUMATIC DISEASES . vol. 70 , A55 - A55 .

El Shikh ME, El Sayed RM, Kmieciak M, Manjili M, Szakal A, Pitzalis C, Tew J ( 2011 ) . BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS . ANNALS OF THE RHEUMATIC DISEASES . vol. 70 ,

Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C ( 2011 ) . EVOLUTION OF ECTOPIC LYMPHOID NEOGENESIS AND IN SITU AUTOANTIBODIES PRODUCTION IN AUTOIMMUNE DIABETIC NOD MICE: CELLULAR AND MOLECULAR CHARACTERISATION OF TERTIARY LYMPHOID STRUCTURES IN PANCREATIC ISLETS . ANNALS OF THE RHEUMATIC DISEASES . vol. 70 ,

de Sande MGHV, Gerlag DM, Lodde BM, van Baarsen LGM, Alivernini S, Codullo V, Felea I, Vieira-Sousa E et al. ( 2011 ) . Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials . ANN RHEUM DIS vol. 70 , ( 3 ) 423 - 427 .

Astorri E ( 2011 ) . Interplay between inflammation, autoimmunity and regeneration in the NOD mouse model of type 1 diabetes and Sjogren’s syndrome . Supervisors: Pitzalis, C, Bombardieri, M ,

Humby F ( 2011 ) . The clinical and immunological significance of ectopic lymphoneogenesis within the rheumatoid synovial membrane . Supervisors: Pitzalis, C, Kirkham, B ,

Bombardieri M, Kam YNW, Filer A, Buckley CD, Pitzalis C ( 2011 ) . Aberrant Basal and TLR-Stimulated Expression of TSLP in Rheumatoid Synovial Fibroblasts . ARTHRITIS AND RHEUMATISM . vol. 63 , S140 - S140 .

Kam NW, Bombardieri M, Filer A, Buckley C, Pitzalis C ( 2011 ) . Aberrant basal and TLR-stimulated expression of TSLP in rheumatoid synovial fibroblasts . IMMUNOLOGY . vol. 135 , 125 - 125 .

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2011 ) . Analysis of recombinant monoclonal antibodies from single B cells reveals early defects of B cell tolerance checkpoints in patients with Sjogren's syndrome . IMMUNOLOGY . vol. 135 , 72 - 72 .

Kamperidis P, Kamalati T, Ferrari M, Lee L, Jones R, Garrood T, Smith MD, Diez-Posada S et al. ( 2011 ) . Development of a Novel Recombinant Biotherapeutic with Applications in Targeted Therapy of Human Arthritis . ARTHRITIS AND RHEUMATISM . vol. 63 , S499 - S499 .

Croia C, Bombardieri M, Serafini B, Coccia EM, Severa M, Kelly S, Aloisi F, Pitzalis C ( 2011 ) . EBV Infection In the Rheumatoid Synovium: Relationship with Ectopic Lymphoid Structures, In Situ Autoantobody Production and CD8 T Cell Activation . ARTHRITIS AND RHEUMATISM . vol. 63 , S140 - S140 .

Nayar S, Barone F, Choy P, Chang M-M, Bombardieri M, Lucchesi D, Pitzalis C, Buckley C ( 2011 ) . Ectopic lymphoneogenesis in a novel murine model of salivary glands sialoadenitis is characterized by asynchrony in the lymphangiogenetic and angiogenetic program . IMMUNOLOGY . vol. 135 , 49 - 49 .

Bombardieri M, Lucchesi D, Barone F, Nayar S, Proctor G, Buckley CD, Pitzalis C ( 2011 ) . Inducible functional tertiary lymphoid structures, autoimmunity and exocrine dysfunction in wild-type mouse salivary glands via local adenoviral delivery . IMMUNOLOGY . vol. 135 , 167 - 167 .

Bugatti S, Manzo A, Bombardieri M, Vitolo B, Humby F, Kelly S, Montecucco C, Pitzalis C ( 2011 ) . Synovial Tissue Heterogeneity and Peripheral Blood Biomarkers . CURRENT RHEUMATOLOGY REPORTS vol. 13 , ( 5 ) 440 - 448 .

Pitzalis C ( 2011 ) . THE ROLE OF SYNOVIAL BIOPSY IN THE DIAGNOSIS OF INFLAMMATORY ARTHRITIS . CLIN EXP RHEUMATOL vol. 29 , ( 1 ) 154 - 154 .

Kurunadalingam H, Parwaiz I, Kumar K, Howlett K, Hands B, Raza K, Pitzalis C, Buckley C et al. ( 2011 ) . THE SAFETY AND ACCEPTABILITY OF ULTRASOUND-GUIDED BIOPSY IN EARLY ARTHRITIS PATIENTS . RHEUMATOLOGY . vol. 50 , 101 - 101 .

Burmester GR, Lipsky PE, Dörner T, for the Kitasato Meeting Faculty ( 2010 ) . Kitasato symposium 2010: new prospects for cytokines . Arthritis Research & Therapy vol. 12 , ( 6 )

Patel HB, Bombardieri M, Sampaio ALF, D'Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C et al. ( 2010 ) . Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis . FASEB J vol. 24 , ( 12 ) 4835 - 4843 .

Corsiero E, Bombardieri M, Humby F, Manzo A, Kelly S, Pitzalis C ( 2010 ) . Characterization of inter follicular large B cells, a new subpopulation of B lymphocytes, in tertiary lymphoid organs in rheumatic autoimmune diseases . IMMUNOLOGY . vol. 131 , 33 - 33 .

Astorri E, Guglielmi C, Bombardieri M, Alessandri C, Buzzetti R, Maggi D, Valesini G, Pitzalis C et al. ( 2010 ) . Circulating Reg1α proteins and autoantibodies to Reg1α proteins as biomarkers of β-cell regeneration and damage in type 1 diabetes . Horm Metab Res vol. 42 , ( 13 ) 955 - 960 .

Croia C, Serafini B, Bombardieri M, Kelly S, Coccia EM, Severa M, Aloisi F, Pitzalis C ( 2010 ) . EBV infection in the rheumatoid arthritis synovium: relationship to tertiary lymphoid structures and CD8 T cell activation . IMMUNOLOGY . vol. 131 , 124 - 124 .

Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C ( 2010 ) . Evolution of ectopic lymphoid neogenesis and in-situ autoantibodies production in autoimmune diabetic NOD mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islet . IMMUNOLOGY . vol. 131 , 63 - 63 .

Lucchesi D, Astorri E, Bombardieri M, Corsiero E, Barone F, Proctor G, Pitzalis C ( 2010 ) . Molecular and cellular evolution of functional tertiary lymphoid structures in salivary glands of NOD mice . IMMUNOLOGY . vol. 131 , 59 - 59 .

Kam NW, Bombardieri M, Brentano F, Choi K, Kyburz D, Gay S, Mclnnes IB, Pitzalis C ( 2010 ) . Rheumatoid synovial fibroblasts support AID expression and Ig class-switching in B cells via a Baff-dependent TLR3-stimulated pathway . IMMUNOLOGY . vol. 131 , 71 - 71 .

Ciccia F, Bombardieri M, Rizzo A, Principato A, Giardina AR, Raiata F, Peralta S, Ferrante A et al. ( 2010 ) . Over-expression of paneth cell-derived anti-microbial peptides in the gut of patients with ankylosing spondylitis and subclinical intestinal inflammation . Rheumatology (Oxford) vol. 49 , ( 11 ) 2076 - 2083 .

Sherwood J, Key S, Achan P, Nalesso G, Pitzalis C, Dell'Accio F ( 2010 ) . CXCR1 AND CXCR2 SIGNALLING IS REQUIRED BUT IS NOT SUFFICIENT TO MAINTAIN THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES . OSTEOARTHRITIS AND CARTILAGE . vol. 18 , S96 - S96 .

Nalesso G, Achan P, Pitzalis C, Dell'Accio F ( 2010 ) . WNT3A MODULATES CHONDROCYTE PHENOTYPE THROUGH ACTIVATION OF BOTH CANONICAL AND NON-CANONICAL PATHWAYS . OSTEOARTHRITIS AND CARTILAGE . vol. 18 , S104 - S105 .

Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C ( 2010 ) . Evolution of ectopic lymphoid neogenesis and in situ autoantibody production in autoimmune nonobese diabetic mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islets . J Immunol vol. 185 , ( 6 ) 3359 - 3368 .

Shirlaw P, Hullah E, Barone F, Panayi G, Kirkham B, Larkin G, Pitzalis C, Cook R et al. ( 2010 ) . Changes in parameters of Sjogrens syndrome (SS) assessed after 10 years on a combined SS clinic . ORAL DIS vol. 16 , ( 6 ) 539 - 539 .

Patel HB, Bombardieri M, Sampaio ALF, D’Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C et al. ( 2010 ) . Anti‐inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis . The FASEB Journal vol. 24 , ( 12 ) 4835 - 4843 .

Ng W-F, Bowman SJ, Griffiths B ( 2010 ) . United Kingdom Primary Sjögren's Syndrome Registry—a united effort to tackle an orphan rheumatic disease . Rheumatology vol. 50 , ( 1 ) 32 - 39 .

Connolly M, Marrelli A, Blades M, McCormick J, Maderna P, Godson C, Mullan R, FitzGerald O et al. ( 2010 ) . Acute Serum Amyloid A Induces Migration, Angiogenesis, and Inflammation in Synovial Cells In Vitro and in a Human Rheumatoid Arthritis/SCID Mouse Chimera Model . J IMMUNOL vol. 184 , ( 11 ) 6427 - 6437 .

Mahoney DJ, Swales C, Athanasou N, Bombardieri M, Pitzalis C, Kliskey K, Sharif M, Day A et al. ( 2010 ) . TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with OPG . Bone vol. 47 ,

Sherwood JC, Achan P, Ramachandran M, Pitzalis C, Dell'Accio F ( 2010 ) . CXCR1/2 SIGNALLING IS REQUIRED FOR THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES . RHEUMATOLOGY . vol. 49 , I13 - I13 .

Sherwood JC, Pitzalis C, Dell'Accio F ( 2010 ) . CXCR1/2 signalling in the phenotypic stability of in vitro expanded adult human articular chondrocytes . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 91 , A40 - A40 .

Nalesso G, Eltawil NM, Pitzalis C, Dell'Accio F ( 2010 ) . Effects of the modulation of Wnt-canonical pathway on the phenotypic stability of human articular chondrocytes . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 91 , A40 - A41 .

Astorri E, Bombardieri M, Corsiero E, Gabba S, Barone F, Proctor G, Pitzalis C ( 2010 ) . MOLECULAR AND CELLULAR EVOLUTION OF FUNCTIONAL TERTIARY LYMPHOID STRUCTURES IN SALIVARY GLANDS OF NOD MICE . RHEUMATOLOGY . vol. 49 , I28 - I28 .

Eltawil N, Pitzalis C, Dell'Accio F ( 2010 ) . Molecular response of articular cartilage to injury: Wnt signaling in an in vivo model of joint surface injury . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 91 , A29 - A29 .

Bombardieri M, Kam YNW, Brentano F, Choi K, Kyburz D, Gay S, McInnes IB, Pitzalis C ( 2010 ) . RHEUMATOID SYNOVIAL FIBROBLASTS SUPPORT AID EXPRESSION AND IG CLASS-SWITCHING IN B CELLS VIA A BAFF-DEPENDENT TLR3-STIMULATED PATHWAY . RHEUMATOLOGY . vol. 49 , I26 - I27 .

Swales C, Mahoney DJ, Athanasou NA, Bombardieri M, Pitzalis C, Sharif O, Day AJ, Milner CM et al. ( 2010 ) . TSG-6: AN AUTOCRINE REGULATOR OF INFLAMMATORY JOINT DISEASE? . RHEUMATOLOGY . vol. 49 , I27 - I27 .

Gillespie J, Savic S, Wong C, Emery P, Grigg R, McDermott MF, Goodall JC, Wu C et al. ( 2010 ) . Concurrent Oral 4 – Basic Science [OP24–OP31] . Rheumatology vol. 49 , ( suppl_1 ) i11 - i13 .

Ritchlin CT, Qureshi AA, de Vlam K, Pitzalis C, Helliwell PS, Mease PJ, Gladman DD, Krueger GG et al. ( 2010 ) . Biomarkers in Psoriasis and Psoriatic Arthritis: GRAPPA 2008 . The Journal of Rheumatology vol. 37 , ( 2 ) 462 - 467 .

Bombardieri M, Astorri E, Corsiero E, Gabba S, Barone F, Proctor G, Pitzalis C ( 2010 ) . MOLECULAR AND CELLULAR EVOLUTION OF FUNCTIONAL TERTIARY LYMPHOID STRUCTURES IN SALIVARY GLANDS OF NOD MICE . ANNALS OF THE RHEUMATIC DISEASES . vol. 69 ,

Manzo A, Bombardieri M, Humby F, Pitzalis C ( 2010 ) . Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling . IMMUNOL REV vol. 233 , 267 - 285 .

Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P et al. ( 2009 ) . Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis . Arterioscler Thromb Vasc Biol vol. 29 , ( 11 ) 1757 - 1763 .

Scheiermann C, Colom B, Meda P, Patel NSA, Voisin M-B, Marrelli A, Woodfin A, Pitzalis C et al. ( 2009 ) . Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury . Arterioscler Thromb Vasc Biol vol. 29 , ( 10 ) 1509 - 1515 .

Macor P, Durigutto P, De Maso L, Cortini A, Garrovo C, Edomi P, Pitzalis C, Tedesco F ( 2009 ) . Prevention of antigen-induced arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5 . MOLECULAR IMMUNOLOGY . vol. 46 , 2837 - 2837 .

Garrood T, Blades M, Haskard DO, Mather S, Pitzalis C ( 2009 ) . A novel model for the pre-clinical imaging of inflamed human synovial vasculature . Rheumatology (Oxford) vol. 48 , ( 8 ) 926 - 931 .

Robinson H, Kelly S, Pitzalis C ( 2009 ) . Basic synovial biology and immunopathology in psoriatic arthritis . J Rheumatol Suppl . vol. 83 , 14 - 16 .

Eltawil NM, De Bari C, Achan P, Pitzalis C, Dell'accio F ( 2009 ) . A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury . Osteoarthritis Cartilage vol. 17 , ( 6 ) 695 - 704 .

Evans HG, Gullick NJ, Kelly S, Pitzalis C, Lord GM, Kirkham BW, Taams LS ( 2009 ) . In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses . Proc Natl Acad Sci U S A vol. 106 , ( 15 ) 6232 - 6237 .

Patel HB, Bombardieri M, Pitzalis C, Perretti M ( 2009 ) . Activation of melanocortin receptor type 3 as a new strategy to control experimental and rheumatoid arthritis . EUR J CLIN INVEST vol. 39 , 29 - 29 .

Bombardieri M, Ciccia F, Principato A, Tripodo C, Peralta S, Triolo G, Pitzalis C ( 2009 ) . IL-23 OVEREXPRESSION AS IMMUNOLOGICAL SIGNATURE OF SUBCLINICAL INTESTINAL INFLAMMATION IN ANKYLOSING SPONDYLITIS . RHEUMATOLOGY . vol. 48 , I6 - I6 .

Ciccia F, Bombardieri M, Principato A, Giardina A, Tripodo C, Porcasi R, Peralta S, Franco V et al. ( 2009 ) . Overexpression of Interleukin-23, but Not Interleukin-17, as an Immunologic Signature of Subdinical Intestinal Inflammation in Ankylosing Spondylitis . ARTHRITIS RHEUM vol. 60 , ( 4 ) 955 - 965 .

Garrood T, Lee L, Blades M, Kamperidis P, Pitzalis C ( 2009 ) . TNF-ALPHA MODULATES TISSUE-SPECIFIC VASCULAR DETERMINANTS RECOGNIZED IN VIVO BY A PHAGE CLONE DISPLAYING A SYNOVIAL-HOMING PEPTIDE IN THE HUMAN/SCID MOUSE TRANSPLANTATION MODEL . RHEUMATOLOGY . vol. 48 , I39 - I39 .

Conigliaro P, Priori R, Bombardieri M, Alessandri C, Barone F, Pitzalis C, McInnes IB, Valesini G ( 2009 ) . Lymph node IL-18 expression in adult-onset Still’s disease . Annals of the Rheumatic Diseases vol. 68 , ( 3 )

Dell'Accio F, Eltawil NM, De Bari C, Pitzalis C ( 2009 ) . WNT16 in joint surface injury and osteoarthritis . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 90 , A84 - A84 .

Kamperidis P ( 2009 ) . Identification of Single-Chain Antibody Fragments Specific for Human Synovial Microvasclar Endothelium by In-Vivo Phage Display . Supervisors: Pitzalis, C, Nissim, A, George, A ,

Keeble J, Blades M, Pitzalis C, da Rocha FAC, Brain SD ( 2009 ) . The role of substance P in microvascular responses in murine joint inflammation . British Journal of Pharmacology vol. 144 , ( 8 ) 1059 - 1066 .

Humby F, Bombardieri M, Manzo A, Kelly S, Blades MC, Kirkham B, Spencer J, Pitzalis C ( 2009 ) . Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium . PLoS Med vol. 6 , ( 1 )

Colom B, Scheiermann C, Woodfin A, Meda P, Patel N, Marrelli A, Pitzalis C, Thiemermann C et al. ( 2009 ) . Effect of soluble JAM-C on leukocyte transmigration in models of ischemia/reperfusion injury . FASEB JOURNAL vol. 23 ,

Evans HG, Gullick NJ, Kelly S, Pitzalis C, Lord GM, Kirkham BW, Taams LS ( 2008 ) . Potent induction of Th17 cells by synovial monocytes from active rheumatoid arthritis patients . IMMUNOLOGY . vol. 125 , 59 - 59 .

Manzo A, Vitolo B, Humby F, Caporali R, Jarrossay D, Dell'Accio F, Ciardelli L, Uguccioni M et al. ( 2008 ) . Mature Antigen-Experienced T Helper Cells Synthesize and Secrete the B Cell Chemoattractant CXCL13 in the Inflammatory Environment of the Rheumatoid Joint . ARTHRITIS RHEUM vol. 58 , ( 11 ) 3377 - 3387 .

Eltawil NM, De Bari C, Achan P, Pitzalis C, Dell’Accio F ( 2008 ) . 54 A NOVEL AGE- AND STRAIN-DEPENDENT IN VIVO MODEL OF ARTICULAR CARTILAGE HEALING IN MICE . Osteoarthritis and Cartilage vol. 16 ,

El Tawil NM, De Bari C, Pitzalis C, Dell'Accio F ( 2008 ) . A mouse model of joint surface injury and repair in mice. Age and strain-dependent outcome . ARTHRITIS AND RHEUMATISM . vol. 58 , S647 - S647 .

Connolly M, McCormick J, Marelli A, Blades M, FitzGerald O, Bresnihan B, Pitzalis C, Veale D et al. ( 2008 ) . A-SAA induces rho GTPase-dependent cytoskeletal rearrangement and in vivo migration of fluorochrome labelled monocytic (u937) cells in a human RA/SCID mice chimera model . ARTHRITIS AND RHEUMATISM . vol. 58 , S627 - S627 .

Humby F, Bombardieri M, Antonio M, Blades M, Bruce K, Spencer J, Pitzalis C ( 2008 ) . Ectopic lymphoid structures expressing AID drive self sustained in situ prodction of autoantibodies in rheumatoid synovium . ARTHRITIS AND RHEUMATISM . vol. 58 , S633 - S634 .

Bugatti S, Manzo A, Caporali R, Scire CA, Vitolo B, Codullo V, Epis OM, Fusetti C et al. ( 2008 ) . Lymphocyte organisation and lymphatic angiogenesis in rheumatoid synovitis: Clinical and radiographic correlates . ARTHRITIS AND RHEUMATISM . vol. 58 , S767 - S768 .

Evans HG, Gullick NJ, Kelly S, Pitzalis C, Kirkham B, Taams LS ( 2008 ) . Potent induction of Th17 cells by synovial monocytes from active rheumatoid arthritis patients . ARTHRITIS AND RHEUMATISM . vol. 58 , S634 - S634 .

Evans HG, Gullick NJ, Kelly S, Pitzalis C, Lord GM, Kirkham BW, Taams LS ( 2008 ) . Potent induction of th17 cells by synovial monocytes from active rheumatoid arthritis patients . ARTHRITIS AND RHEUMATISM . vol. 58 , S165 - S166 .

Humby F, Gullick N, Kelly S, Pitzalis C, Oakley SP ( 2008 ) . A synovial pathergy reaction leading to a pseudo-septic arthritis and a diagnosis of Behcet's disease . RHEUMATOLOGY vol. 47 , ( 8 ) 1255 - 1256 .

Kelly S, Taylor P, Pitzalis C ( 2008 ) . Ultrasound imaging in spondyloathropathies: from imaging to diagnostic intervention . Curr Opin Rheumatol vol. 20 , ( 4 ) 408 - 415 .

Costantinides Y, Kingsley G, Pitzalis C, Panayi GS ( 2008 ) . Inhibition of lymphocyte proliferation by a monoclonal antibody (RFT2) against CD7 . Clinical & Experimental Immunology vol. 85 , ( 1 ) 164 - 167 .

RODRIGUEZ RM, PITZALIS C, KINGSLEY GH, HENDERSON E, HUMPHRIES MJ, PANAYI GS ( 2008 ) . T lymphocyte adhesion to fibronectin (FN): a possible mechanism for T cell accumulation in the rheumatoid joint . Clinical & Experimental Immunology vol. 89 , ( 3 ) 439 - 445 .

Lymphoma RTRTALBOISS-RMSAL-GPB-C, Quartuccio L, Fabris M, Moretti M, Barone F, Bombardieri M, Rupolo M, Lombardi S et al. ( 2008 ) . Resistance to Rituximab Therapy and Local BAFF Overexpression in Sjögren’s Syndrome-Related Myoepithelial Sialadenitis and Low-Grade Parotid B-Cell Lymphoma . The Open Rheumatology Journal vol. 2 , ( 1 ) 38 - 43 .

Dell'accio F, De Bari C, Eltawil NM, Vanhummelen P, Pitzalis C ( 2008 ) . Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis . Arthritis Rheum vol. 58 , ( 5 ) 1410 - 1421 .

Bombardieri M, Barone F, Humby F, Morgan P, Challacombe S, Spencer J, Pitzalis C ( 2008 ) . Activation-induced cytidine deaminase expression supports functionality of ectopic lymphoid neogenesis in patients with and animal models of Sjogren's syndrome . RHEUMATOLOGY . vol. 47 , II85 - II85 .

Humby F, Bombardieri M, Manzo A, Blades M, Kirkham B, Spencer J, Pitzalis C ( 2008 ) . Activation-induced cytidine deaminase supports self sustained autoantibody production within RA synovium . RHEUMATOLOGY . vol. 47 , II59 - II59 .

Barone F, Bombardieri M, Rosado MM, Morgan PR, Challacombe SJ, De Vita S, Carsetti R, Spencer J et al. ( 2008 ) . CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: Association with reactive and malignant areas of lymphoid organization . J IMMUNOL vol. 180 , ( 7 ) 5130 - 5140 .

Garrood T, Blades M, Mather S, Haskard D, Pitzalis C ( 2008 ) . Imaging E-selectin expression in human synovium in a scid mouse transplantation model . RHEUMATOLOGY . vol. 47 , II55 - II55 .

Evans HG, Gullick NJ, Kelly S, Pitzalis C, Lord GM, Kirkham BW, Taams LS ( 2008 ) . Potent induction of interleukin-17 producing CD4+ T cells (TH17 cells) by synovial monocytes from active RA patients . RHEUMATOLOGY . vol. 47 , II59 - II59 .

Dell'Accio F, Eltawil NM, De Bari C, Pitzalis C ( 2008 ) . Wnt16 in joint surface injury and osteoarthritis . RHEUMATOLOGY . vol. 47 , II177 - II178 .

Bombardieri M, Barone F, Pitzalis C ( 2008 ) . Response to comment on "Activation-Induced Cyridine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis aud MALT Lymphoma in Sjogren's Syndrome" . J IMMUNOL vol. 180 , ( 4 ) 2008 - 2009 .

De Bari C, Dell'Accio F, Karystinou A, Guillot PV, Fisk NM, Jones EA, McGonagle D, Khan IM et al. ( 2008 ) . A biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells . Arthritis Rheum vol. 58 , ( 1 ) 240 - 250 .

Astorri E, Bombardieri M, Guglielmi C, Pitzalis C, Pozzilli P ( 2008 ) . Beta cell regeneration in type 1 diabetes: the role of Reg genes in NOD mice . DIABETOLOGIA vol. 51 , S186 - S186 .

Evans H, Gullick N, Kelly S, Pitzalis C, Lord G, Kirkham B, Taams L ( 2008 ) . Potent induction of interleukin-17 producing CD4+T cells (Th17 cells) by synovial monocytes from active RA patients . CLINICAL IMMUNOLOGY . vol. 127 , S20 - S20 .

Manzo A ( 2008 ) . Re-programming of the CXCL13-CCL21 Lymphoid Chemokine System in Ectopic Lymphoid Neogenesis during Chronic Arthritis . Supervisors: Pitzalis, C, Hayday, A ,

Gerli R, Lunardi C, Bocci EB, Bobbio-Pallavicini F, Schillaci G, Caporali R, Bistoni O, Pirro M et al. ( 2007 ) . Anti-tumor necrosis factor-alpha response in rheumatoid arthritis is associated with an increase in serum soluble CD30 . The Journal of Rheumatology vol. 35 , ( 1 ) 14 - 19 .

Manzo A, Bugatti S, Caporali R, Prevo R, Jackson DG, Uguccioni M, Buckley CD, Montecucco C et al. ( 2007 ) . CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis . AM J PATHOL vol. 171 , ( 5 ) 1549 - 1562 .

Manzo A, Pitzalis C ( 2007 ) . Lymphoid tissue reactions in rheumatoid arthritis . Autoimmun Rev vol. 7 , ( 1 ) 30 - 34 .

Barone F, Bombardieri M, Spencer J, Isaacson P, Humby F, Morgan P, Challacombe S, Valesini G et al. ( 2007 ) . CXCL13, CCL21 and CXCL12 are upregulated in mucosal-associated lymphoid tissue lymphomas in patients with Sjorgen's syndrome and cooperate in the maintenance of the immune response and malignant cell survival . Arthritis Research & Therapy vol. 9 , ( Suppl 3 )

Bombardieri M, Barone F, Humby F, Kelly S, McGurk M, Morgan P, Challacombe S, De Vita S et al. ( 2007 ) . Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjögren's syndrome . J Immunol vol. 179 , ( 7 ) 4929 - 4938 .

Choy EHS, Smith CM, Farewell V, Walker D, Hassell A, Chau L, Scott DL, Group FTCT ( 2007 ) . Factorial randomised controlled trial of glucocorticoids and combination disease modifying drugs in early rheumatoid arthritis . Annals of the Rheumatic Diseases vol. 67 , ( 5 )

de Bari C, Guillot PV, Fisk NM, Jones EA, McGonagle D, Khan IM, Archer CW, Mitsiadis TA et al. ( 2007 ) . Mathematical modeling to predict bone forming potency of human mesenchymal stem cells . European Cells and Materials . vol. 14 ,

Brunton F, Lee L, Nissim A, Grigoriadis AE, Pitzalis C ( 2007 ) . Targeting osteoclasts in rheumatoid arthritis via the alpha(v)beta(3) integrin . JOURNAL OF BONE AND MINERAL RESEARCH . vol. 22 , 1113 - 1113 .

Humby F, Manzo A, Kirkham B, Pitzalis C ( 2007 ) . The synovial membrane as a prognostic tool in rheumatoid arthritis . Autoimmun Rev vol. 6 , ( 4 ) 248 - 252 .

Tyndall A, Walker UA, Cope A, Dazzi F, De Bari C, Fibbe W, Guiducci S, Jones S et al. ( 2007 ) . Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005 . Arthritis Research & Therapy vol. 9 , ( 1 )

Kamperidis PS, Lee L, Blades M, Garrood T, Nissim A, George A, Pitzalis C ( 2007 ) . Identification of single-chain antibody fragments specific for human synovial microvascular endothelium by in vivo phage display . ANNALS OF THE RHEUMATIC DISEASES . vol. 66 , A12 - A13 .

Scire CA, Epis O, Codullo V, Humby F, Morbini P, Manzo A, Caporali R, Pitzalis C et al. ( 2007 ) . Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure . ARTHRITIS RES THER vol. 9 , ( 5 ) Article R101 ,

Lee L, Garrood T, Pitzalis C ( 2007 ) . In vivo phage display selection in the human/SCID mouse chimera model for defining synovial specific determinants . Methods Mol Med vol. 136 , 369 - 394 .

Bombardieri M, McInnes IB, Pitzalis C ( 2007 ) . Interleukin-18 as a potential therapeutic target in chronic autoimmune/inflammatory conditions . Expert Opin Biol Ther vol. 7 , ( 1 ) 31 - 40 .

Brunton F, Lee L, Nissim A, Grigoriadis A, Pitzalis C ( 2007 ) . Modulating osteoclast function by targeting the alphavbeta3 integrin . ANNALS OF THE RHEUMATIC DISEASES . vol. 66 , A19 - A19 .

De Bari C, Pringle S, Pitzalis C, Dell'Accio F ( 2006 ) . The stem cell niche: a new target in medicine . Current Orthopaedic Practice vol. 17 , ( 5 ) 398 - 404 .

DELL'ACCIO F, Pitzalis C, Barone F, Mitsiadis T, De Bari C ( 2006 ) . Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury . Arthritis Research & Therapy vol. 8 , ( 5 ) R139 - R139 .

KINGSLEY G, PITZALIS C, KYRIAZIS N, PANAYI GS ( 2006 ) . Abnormal Helper‐Inducer/Suppressor–Inducer T‐Cell Subset Distribution and T‐Cell Activation Status are Common to All Types of Chronic Synovitis . Scandinavian Journal of Immunology vol. 28 , ( 2 ) 225 - 232 .

Pitzalis C, Garrood T ( 2006 ) . From ubiquitous antigens to joint-specific inflammation: could local vascular permeability be the missing link? . Trends in Immunology vol. 27 , ( 7 ) 299 - 302 .

Filer A, Pitzalis C, Buckley CD ( 2006 ) . Targeting the stromal microenvironment in chronic inflammation . Current Opinion in Pharmacology vol. 6 , ( 4 ) 393 - 400 .

PITZALIS C, Barone F, Peakman M, Lozanoska-Ochser B ( 2006 ) . Atorvastatin fails to prevent the development of autoimmune diabetes despite inhibition of pathogenic beta-cell-specific CD8 T-cells . Diabetes vol. 55 , ( 4 ) 1004 - 1010 .

De Bari C, Dell'Accio F, Vanlauwe J, Eyckmans J, Khan IM, Archer CW, Jones EA, McGonagle D et al. ( 2006 ) . Mesenchymal multipotency of adult human periosteal cells demonstrated by single‐cell lineage analysis . Arthritis & Rheumatism vol. 54 , ( 4 ) 1209 - 1221 .

Garrood T, Pitzalis C ( 2006 ) . Targeting the inflamed synovium: The quest for specificity . Arthritis & Rheumatism vol. 54 , ( 4 ) 1055 - 1060 .

DeBari C, Pitzalis C, Dell'Accio F ( 2005 ) . Reparative medicine: from tissue engineering to joint surface regeneration . Regenerative Medicine vol. 1 , ( 1 ) 59 - 69 .

Pitzalis C, Kingsley GH, Haskard DO, Panayi GS ( 2005 ) . Comment on the article by Lasky et a1 . Arthritis & Rheumatism vol. 32 , ( 1 ) 116 - 117 .

Pitzalis C, Cauli A, Pipitone N, Smith C, Barker J, Marchesoni A, Yanni G, Panayi GS ( 2005 ) . Cutaneous lymphocyte antigen‐positive T lymphocytes preferentially migrate to the skin but not to the joint in psoriatic arthritis . Arthritis & Rheumatism vol. 39 , ( 1 ) 137 - 145 .

Choy EHS, Pitzalis C, Cauli A, Bijl JA, Schantz A, Woody J, Kingsley GH, Panayi GS ( 2005 ) . Percentage of anti‐CD4 monoclonal antibody‐coated lymphocytes in the rheumatoid joint is associated with clinical improvement. Implications for the development of immunotherapeutic dosing regimens . Arthritis & Rheumatism vol. 39 , ( 1 ) 52 - 56 .

Sieper J, Kingsley G, Palacios‐Boix A, Pitzalis C, Panayi GS, Treharne J, Hughes R, Keat A ( 2005 ) . Synovial T lymphocyte–specific immune response to Chlamydia trachomatis in Reiter's disease . Arthritis & Rheumatism vol. 34 , ( 5 ) 588 - 598 .

Garrood T, Lee L, Pitzalis C ( 2005 ) . Molecular mechanisms of cell recruitment to inflammatory sites: general and tissue-specific pathways . Rheumatology vol. 45 , ( 3 ) 250 - 260 .

Pitzalis C, Kingsley G, Haskard D, Panayi G ( 2005 ) . The preferential accumulation of helper‐inducer T lymphocytes in inflammatory lesions: evidence for regulation by selective endothelial and homotypic adhesion . European Journal of Immunology vol. 18 , ( 9 ) 1397 - 1404 .

Pitzalis C, Kingsley GH, Covelli M, Meliconi R, Markey A, Panayi GS ( 2005 ) . Selective migration of the human helper‐inducer memory T cell subset: confirmation by in vivo cellular kinetic studies . European Journal of Immunology vol. 21 , ( 2 ) 369 - 376 .

Bugatti S, Caporali R, Manzo A, Vitolo B, Pitzalis C, Montecucco C ( 2005 ) . Involvement of subchondral bone marrow in rheumatoid arthritis: Lymphoid neogenesis and in situ relationship to subchondral bone marrow osteoclast recruitment . Arthritis & Rheumatism vol. 52 , ( 11 ) 3448 - 3459 .

PITZALIS C, Manzo A, Bombardieri M, Valesini G, Challacombe SJ, Morgan PR, Barone F, Blades MC ( 2005 ) . Association of CXCL13 and CCL21 Expression With the Progressive Organization of Lymphoid-like Structures in Sjogren’s Syndrome . Arthritis & Rheumatism vol. 52 , ( 6 ) 1773 - 1784 .

PITZALIS C, Manzo A, Uguccioni M, Caporali R, Bresnihan B, Blades MC, Barone F, Yanni G et al. ( 2005 ) . Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis . Eur J Immunol vol. 35 , 1347 - 1359 .

Pipitone N, Pitzalis C ( 2005 ) . Recent advances in the treatment of psoriatic arthritis . Expert Opinion on Therapeutic Patents vol. 14 , ( 4 ) 509 - 525 .

Manzo A, Bugatti S, Buckley C, Jackson D, Caporali R, Montecucco C, Pitzalis C ( 2005 ) . CCL21 relationship with lymphoid neogenesis and lymphatic vascular system in chronically inflamed synovium . Arthritis Research & Therapy vol. 7 , ( Suppl 1 )

De Bari C, Dell'Accio F, Vanlauwe J, Pitzalis C, Luyten F ( 2005 ) . Distinct biological properties of human mesenchymal stem cells from different sources . Arthritis Research & Therapy vol. 7 , ( Suppl 1 )

Bombardieri M, Barone F, Proctor G, van de Loo F, van den Berg W, Valesini G, McInnes I, Pitzalis C ( 2005 ) . Efficient IL-18 and IL-18BPc adenoviral gene transfer to cultured murine submandibular gland epithelial cells and successful murine retrograde submandibular duct cannulation to modulate IL-18 function in the salivary gland of animal models of Sjogren's syndrome . Arthritis Research & Therapy vol. 7 , ( Suppl 1 )

Dell'Accio F, De Bari C, Pitzalis C ( 2005 ) . Molecular response to cartilage injury . Arthritis Research & Therapy vol. 7 , ( Suppl 1 )

Barone F, Bombardieri M, Blades M, Manzo A, Morgan P, Challacombe S, Valesini G, Pitzalis C ( 2004 ) . Lymphoid chemokine expression in Sjogren's syndrome: relationship with the lymphoid organization of the periductal inflammatory aggregates . Arthritis Research & Therapy vol. 6 , ( Suppl 3 )

Pipitone N, Pitzalis C ( 2004 ) . Arthritides in the elderly . Recenti Progressi in Medicina vol. 95 , ( 9 ) 432 - 442 .

Bombardieri M, Barone F, Pittoni V, Alessandri C, Conigliaro P, Blades MC, Priori R, McInnes IB et al. ( 2004 ) . Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate . Arthritis Research & Therapy vol. 6 , ( 5 )

Pitzalis C, Manzo A, Paoletti S, Barone F, Caporali R, Montecucco C, Uguccioni M ( 2003 ) . Lymphoid neogenesis in chronic inflammation . Arthritis Research & Therapy vol. 5 , ( Suppl 3 )

De Benedetti F, Pignatti P, Biffi M, Bono E, Wahid S, Ingegnoli F, Chang S-YP, Alexander H et al. ( 2003 ) . Increased expression of alpha(1,3)-fucosyltransferase-VII and P-selectin binding of synovial fluid T cells in juvenile idiopathic arthritis . The Journal of Rheumatology vol. 30 , ( 7 ) 1611 - 1615 .

Pipitone N, Kingsley GH, Manzo A, Scott DL, Pitzalis C ( 2003 ) . Current concepts and new developments in the treatment of psoriatic arthritis . Rheumatology vol. 42 , ( 10 ) 1138 - 1148 .

George AJT, Lee L, Pitzalis C ( 2003 ) . Isolating ligands specific for human vasculature using in vivo phage selection . Trends in Biotechnology vol. 21 , ( 5 ) 199 - 203 .

Manzo A, Carulli M, Paoletti S, Blades M, Barone F, Yanni G, Caporali R, Montecucco C et al. ( 2003 ) . BCA-1 (CXCL13) and SLC (CCL21) production and lymphoid neogenesis in rheumatoid synovitis . Arthritis Research & Therapy vol. 5 , ( Suppl 1 )

Barone F, Blades M, Manzo A, Morgan P, Montecucco M, Valesini G, Pitzalis C ( 2003 ) . CXCL13 and CCL21 play a key role in ectopic lymphoneogenesis in Sjögren's syndrome . Arthritis Research & Therapy vol. 5 , ( Suppl 1 )

Lee L, Buckley C, Blades M, Panayi G, George A, Pitzalis C ( 2003 ) . Identification of homing peptides specific for human synovium by in vivo phage display selection . Arthritis Research & Therapy vol. 5 , ( Suppl 1 )

Manzo A, Caporali R, Montecucco C, Pitzalis C ( 2003 ) . Role of chemokines and chemokine receptors in regulating specific leukocyte trafficking in the immune/inflammatory response . Clinical and Experimental Rheumatology vol. 21 , ( 4 ) 501 - 508 .

Gerli R, Lunardi C, Pitzalis C ( 2002 ) . Unmasking the anti‐inflammatory cytokine response in rheumatoid synovitis . Rheumatology vol. 41 , ( 12 ) 1341 - 1345 .

Gerli R, Pitzalis C, Lunardi C ( 2002 ) . The role of T cell cytokines in modulating joint inflammation in rheumatoid arthritis . Israel Medical Association Journal vol. 4 , ( 11 Suppl ) 949 - 952 .

Perretti M, Ingegnoli F, Wheller SK, Blades MC, Solito E, Pitzalis C ( 2002 ) . Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model . J Immunol vol. 169 , ( 4 ) 2085 - 2092 .

PITZALIS C, Lee L, Panayi G, Buckley C, Blades MC ( 2002 ) . Identification of Synovium-Specific Homing Peptides by In Vivo Phage Display Selection . Arthritis & Rheumatism vol. 46 , ( 8 ) 2109 - 2120 .

Blades MC, Manzo A, Ingegnoli F, Taylor PR, Panayi GS, Irjala H, Jalkanen S, Haskard DO et al. ( 2002 ) . Stromal cell-derived factor 1 (CXCL12) induces human cell migration into human lymph nodes transplanted into SCID mice . J IMMUNOL vol. 168 , ( 9 ) 4308 - 4317 .

Perretti M, Blades MC, Wheller SK, Wahid S, Solito E, Pitzalis C ( 2002 ) . Monocytic cells over-expressing annexin 1 have reduced transmigration in vitro and elicitation in vivo . FASEB J . vol. 16 , A598 - A598 .

Blades MC, Ingegnoli F, Wheller SK, Manzo A, Wahid S, Panayi GS, Perretti M, Pitzalis C ( 2002 ) . Stromal cell-derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID mice . ARTHRITIS RHEUM vol. 46 , ( 3 ) 824 - 836 .

Matsuno H, Yudoh K, Katayama R, Nakazawa F, Uzuki M, Sawai T, Yonezawa T, Saeki Y et al. ( 2002 ) . The role of TNF‐α in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA/SCID mouse chimera . Rheumatology vol. 41 , ( 3 ) 329 - 337 .

Lee L, Buckley C, Blades M, Panayi G, George A, Pitzalis C ( 2002 ) . Identification of homing peptides specific for synovial microvascular endothelium using in vivo phage display selection . Arthritis Research & Therapy vol. 4 , ( Suppl 1 )

Blades M, Manzo A, Ingegnoli F, Taylor P, Irjala H, Jalkanen S, Haskard D, Perretti M et al. ( 2002 ) . Stromal cell derived factor-1 (CXCL12) induces cell migration into lymph nodes transplanted into SCID MICE. An investigation of lymphocyte migration to secondary lymphoid organs . Arthritis Research & Therapy . vol. 4 ,

Pitzalis C, Pipitone N, Perretti M ( 2002 ) . Regulation of leukocyte-endothelial interactions by glucocorticoids . NEUROENDOCRINE IMMUNE BASIS OF THE RHEUMATIC DISEASES II, PROCEEDINGS . Editors: Cutolo, M, Bijlsma, JWJ, Lahita, RG, Masi, AT et al. , vol. 966 , 108 - 118 .

Goulding NJ, Ogbourn S, Pipitone N, Biagini P, Gerli R, Pitzalis C ( 2001 ) . The inhibitory effect of dexamethasone on lymphocyte adhesion molecule expression and intercellular aggregation is not mediated by lipocortin 1 . Clinical & Experimental Immunology vol. 118 , ( 3 ) 376 - 383 .

Wahid S, Blades MC, De Lord D, Brown I, Blake G, Yanni G, Haskard DO, Panayi GS et al. ( 2001 ) . Tumour necrosis factor-alpha (TNF-α) enhances lymphocyte migration into rheumatoid synovial tissue transplanted into severe combined immunodeficient (SCID) mice . Clinical & Experimental Immunology vol. 122 , ( 1 ) 133 - 142 .

Pipitone N, Sinha M, Theodoridis E, Goulding N, Hall M, Lanchbury J, Corrigall V, Panayi G et al. ( 2001 ) . The glucocorticoid inhibition of LFA-1 and CD2 expression by human mononuclear cells is reversed by IL-2, IL-7 and IL-15 . EUR J IMMUNOL vol. 31 , ( 7 ) 2135 - 2142 .

Panayi GS, Corrigall VM, Pitzalis C ( 2001 ) . PATHOGENESIS OF RHEUMATOID ARTHRITIS The Role of T Cells and Other Beasts . Rheumatic Disease Clinics of North America vol. 27 , ( 2 ) 317 - 334 .

Pitzalis C ( 2001 ) . In vivoselection of synovial specific targets using phage display technology . Arthritis Research & Therapy vol. 3 , ( Suppl 1 )

Pitzalis C, Pipitone N, Pipitone V, Fioravanti A, Marcolongo R ( 2001 ) . Rheumatoid arthritis. Recent findings and new pathogenic concepts . Recenti Progressi in Medicina vol. 92 , ( 3 ) 217 - 222 .

Gerli R, Lunardi C, Vinante F, Bistoni O, Pizzolo G, Pitzalis C ( 2001 ) . Role of CD30+ T cells in rheumatoid arthritis: a counter-regulatory paradigm for Th1-driven diseases . Trends in Immunology vol. 22 , ( 2 ) 72 - 77 .

Pipitone N, Fioravanti A, Marcolongo R, Pitzalis C ( 2001 ) . Articular involvement in the course of primary hypogammaglobulinemia . Recenti Progressi in Medicina vol. 92 , ( 1 ) 63 - 67 .

Pitzalis C, Pipitone N, Perretti M ( 2001 ) . Glucocorticoids and leukocyte adhesion . Glucocorticoids , Springer Nature

Pipitone N, Pipitone V, Pitzalis C ( 2001 ) . Glucocorticoids at the threshold of the new millennium: recent findings on the anti-inflammatory and immunomodulator mechanisms of action and future perspectives . Internal and Emergency Medicine vol. 16 , ( 3 ) 141 - 154 .

Huizinga TW, Keijsers V, Yanni G, Hall M, Ramage W, Lanchbury J, Pitzalis C, Drossaers-Bakker WK et al. ( 2000 ) . Are differences in interleukin 10 production associated with joint damage? . Rheumatology vol. 39 , ( 11 ) 1180 - 1188 .

Pipitone N, Jolliffe VA, Cauli A, Scott DG, Pitzalis C ( 2000 ) . Do B cells influence disease progression in chronic synovitis? Lessons from primary hypogammaglobulinaemia . Rheumatology vol. 39 , ( 11 ) 1280 - 1285 .

Pitzalis C, Koch A ( 2000 ) . THE VASCULAR ENDOTHELIAL SYSTEM IN THE PATHOGENESIS OF INFLAMMATION AND SYSTEMIC RHEUMATIC DISEASES: RELATION TO THE NEUROENDOCRINE SYSTEM . Rheumatic Disease Clinics of North America vol. 26 , ( 4 ) 765 - 773 .

Pitzalis C, Pipitone N ( 2000 ) . Psoriatic arthritis . Journal of the Royal Society of Medicine vol. 93 , ( 8 ) 412 - 415 .

Cauli A, Pitzalis C, Yanni G, Awad M, Panayi GS ( 2000 ) . CD1 expression in psoriatic and rheumatoid arthritis . Rheumatology vol. 39 , ( 6 ) 666 - 673 .

Gerli R, Pitzalis C, Bistoni O, Falini B, Costantini V, Russano A, Lunardi C ( 2000 ) . CD30+ T Cells in Rheumatoid Synovitis: Mechanisms of Recruitment and Functional Role . The Journal of Immunology vol. 164 , ( 8 ) 4399 - 4407 .

Pipitone N, Pitzalis C ( 2000 ) . The role of chemokines in inflammation and rheumatoid arthritis . Current Opinion in Anti-inflammatory and Immunomodulatory Investigational Drugs vol. 2 , ( 1 ) 9 - 15 .

Gerli R, Bistoni O, Lunardi C, Giacomelli R, Tomassini C, Biagini P, Pitzalis C ( 1999 ) . Soluble CD30 in early rheumatoid arthritis as a predictor of good response to second-line therapy . Rheumatology vol. 38 , ( 12 ) 1282 - 1284 .

Masi AT, Bijlsma JWJ, Chikanza IC, Pitzalis C, Cutolo M ( 1999 ) . Neuroendocrine, immunologic, and microvascular systems interactions in rheumatoid arthritis: physiopathogenetic and therapeutic perspectives . Seminars in Arthritis and Rheumatism vol. 29 , ( 2 ) 65 - 81 .

Perretti M, Wheller SK, Flower RJ, Wahid S, Pitzalis C ( 1999 ) . Modulation of cellular annexin I in human leukocytes infiltrating DTH skin reactions . Journal of Leukocyte Biology vol. 65 , ( 5 ) 583 - 589 .

Howie D, Spencer J, DeLord D, Pitzalis C, Wathen NC, Dogan A, Akbar A, MacDonald TT ( 1998 ) . Extrathymic T cell differentiation in the human intestine early in life . The Journal of Immunology vol. 161 , ( 11 ) 5862 - 5872 .

Choy EH, Schantz A, Pitzalis C, Kingsley GH, Panayi GS ( 1998 ) . The pharmacokinetics and human anti-mouse antibody response in rheumatoid arthritis patients treated with a chimeric anti-CD4 monoclonal antibody . Rheumatology vol. 37 , ( 7 ) 801 - 802 .

Pitzalis C ( 1998 ) . Skin and joint disease in psoriatic arthritis: what is the link? . Rheumatology vol. 37 , ( 5 ) 480 - 483 .

Pitzalis C, Choy E ( 1998 ) . Fourth International Symposium on the Immunotherapy of the Rheumatic Diseases. 21-25 May 1997, Cyprus . Annals of the Rheumatic Diseases . vol. 57 ,

Pitzalis C, Choy E ( 1998 ) . Fourth International Symposium on the Immunotherapy of the Rheumatic Diseases . Annals of the Rheumatic Diseases . vol. 57 , 177 - 179 .

Pitzalis C, Pipitone N, Bajocchi G, Hall M, Goulding N, Lee A, Kingsley G, Lanchbury J et al. ( 1997 ) . Corticosteroids inhibit lymphocyte binding to endothelium and intercellular adhesion: an additional mechanism for their anti-inflammatory and immunosuppressive effect . The Journal of Immunology vol. 158 , ( 10 ) 5007 - 5016 .

Pitzalis C, Sharrack B, Gray IA, Lee A, Hughes RAC ( 1997 ) . Comparison of the effects of oral versus intravenous methylprednisolone regimens on peripheral blood T lymphocyte adhesion molecule expression, T cell subsets distribution and TNF alpha concentrations in multiple sclerosis . Journal of Neuroimmunology vol. 74 , ( 1-2 ) 62 - 68 .

Pitzalis C, Pipitone N, Marcolongo R, Galeazzi M ( 1997 ) . Monoclonal antibody therapy . Recenti Progressi in Medicina vol. 88 , ( 3 ) 128 - 133 .

PITZALIS C ( 1996 ) . ROLE OF ADHESION MECHANISMS IN THE PATHOGENESIS OF CHRONIC SYNOVITIS . Rheumatology vol. 35 , ( 12 ) 1198 - 1215 .

Yanni G, Ramage W, Pitzalis C, Hall M, Lanchbury J, Panayi G ( 1996 ) . Th1 and Th2 cytokines in rheumatoid arthritis . FASEB Journal vol. 10 , ( 6 )

Cauli A, Yanni G, Pitzalis C, Challacombe S, Panayi GS ( 1995 ) . Cytokine and adhesion molecule expression in the minor salivary glands of patients with Sjögren's syndrome and chronic sialoadenitis . Annals of the Rheumatic Diseases vol. 54 , ( 3 )

Pipitone N, Bajocchi G, Pitzalis C ( 1995 ) . Leucocyte adhesion and migration mechanism during inflammation: Role in pathogenesis and prospects for therapy . Reumatismo vol. 47 , ( 2 ) 116 - 125 .

Meliconi R, Uguccioni M, Chieco-Bianchi F, Pitzalis C, Bowman S, Facchini A, Gasbarrini G, Panayi GS et al. ( 1995 ) . The role of interleukin-8 and other cytokines in the pathogenesis of Felty's syndrome . Clinical and Experimental Rheumatology vol. 13 , ( 3 ) 285 - 291 .

Pitzalis C, Kingsley G, Panayi G ( 1994 ) . Adhesion molecules in rheumatoid arthritis: role in the pathogenesis and prospects for therapy . Annals of the Rheumatic Diseases vol. 53 , ( 5 )

Pitzalis C, Choy E, Kingsley G ( 1994 ) . Monoclonal antibody therapy in rheumatic disease . La Presse Médicale vol. 23 , ( 11 ) 532 - 539 .

Arnold MH, Pitzalis C, Corrigall VM, Panayi GS ( 1994 ) . CD8 lymphocytes in polymyalgia rheumatica and giant cell arteritis: a reply . Clinical and Experimental Rheumatology vol. 12 , ( 2 )

Lanchbury JS, Pitzalis C ( 1993 ) . Cellular immune mechanisms in rheumatoid arthritis and other inflammatory arthritides . Current Opinion in Immunology vol. 5 , ( 6 ) 918 - 924 .

( 1993 ) . BSR Poster Session a . Rheumatology vol. 32 , ( suppl_1 ) 3 - 88 .

Pitzalis C ( 1993 ) . Adhesion and migration of inflammatory cells . Clinical and Experimental Rheumatology . vol. 11 Suppl 8 , s71 - s76 .

Arnold MH, Corrigall VM, Pitzalis C, Panayi GS ( 1993 ) . The sensitivity and specificity of reduced CD8 lymphocyte levels in the diagnosis of polymyalgia rheumatica/giant cell arteritis . Clinical and Experimental Rheumatology vol. 11 , ( 6 ) 629 - 634 .

Kirkham BW, Thien F, Pelton BK, Pitzalis C, Amlot P, Denman AM, Panayi GS ( 1992 ) . Chimeric CD7 monoclonal antibody therapy in rheumatoid arthritis . The Journal of Rheumatology vol. 19 , ( 9 ) 1348 - 1352 .

Panayi GS, Kingsley GH, Pitzalis C ( 1992 ) . Adhesion of peripheral blood lymphocytes to high endothelial venules of gut mucosa . Annals of the Rheumatic Diseases vol. 51 , ( 7 )

Meliconi R, Kingsley GH, Pitzalis C, Sakkas L, Panayi GS ( 1992 ) . Analysis of lymphocyte phenotype and T cell receptor genotype in Felty's syndrome . The Journal of Rheumatology vol. 19 , ( 7 ) 1058 - 1064 .

Groves RW, Simpson KJ, Koblar S, Pitzalis C, Hay RJ ( 1992 ) . Tryptophan Induced Eosinophilia-Myalgia Syndrome: Clinical and Microscopic Findings . Journal of the Royal Society of Medicine vol. 85 , ( 2 ) 111 - 112 .

KIRKHAM BW, PITZALIS C, KINGSLEY GH, CHIKANZA IC, SABHARWAL S, BARBATIS C, GRAHAME R, GIBSON T et al. ( 1991 ) . MONOCLONAL ANTIBODY TREATMENT IN RHEUMATOID ARTHRITIS: THE CLINICAL AND IMMUNOLOGICAL EFFECTS OF A CD7 MONOCLONAL ANTIBODY . Rheumatology vol. 30 , ( 6 ) 459 - 463 .

Meliconi R, Pitzalis C, Kingsley GH, Panayi GS ( 1991 ) . γδ T cells and their subpopulations in blood and synovial fluid from rheumatoid arthritis and spondyloarthritis . Clinical Immunology vol. 59 , ( 1 ) 165 - 172 .

Wellicome SM, Thornhill MH, Pitzalis C, Thomas DS, Lanchbury JS, Panayi GS, Haskard DO ( 1990 ) . A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1, or lipopolysaccharide . The Journal of Immunology vol. 144 , ( 7 ) 2558 - 2565 .

RIDLEY MG, KINGSLEY G, PITZALIS C, PANAYI GS ( 1990 ) . MONOCYTE ACTIVATION IN RHEUMATOID ARTHRITIS: EVIDENCE FOR IN SITU ACTIVATION AND DIFFERENTIATION IN JOINTS . Rheumatology vol. 29 , ( 2 ) 84 - 88 .

MARKEY AC, ALLEN MH, PITZALIS C, MACDONALD DM ( 1990 ) . T‐cell inducer populations in cutaneous inflammation: a predominance of T helper‐inducer lymphocytes (THi) in the infiltrate of inflammatory dermatoses . British Journal of Dermatology vol. 122 , ( 3 ) 325 - 332 .

KINGSLEY G, PITZALIS C, PANAYI GS ( 1990 ) . IMMUNOGENETIC AND CELLULAR IMMUNE MECHANISMS IN RHEUMATOID ARTHRITIS: RELEVANCE TO NEW THERAPEUTIC STRATEGIES . Rheumatology vol. 29 , ( 1 ) 58 - 64 .

Pitzalis C, Sieper J, Kingsley G, Keat A, Panayi G ( 1990 ) . The immunopathology of sexually acquired reactive arthritis: The role of Chlamydia trachomatis . Reumatismo . vol. 42 , 191 - 197 .

Dasgupta B, Pitzalis C, Panayi GS ( 1989 ) . Inflammation of the uveal tract as a presenting feature of temporal arteritis . Annals of the Rheumatic Diseases vol. 48 , ( 11 )

Dasgupta B, Duke O, Timms AM, Pitzalis C, Panayi GS ( 1989 ) . Selective depletion and activation of CD8+ lymphocytes from peripheral blood of patients with polymyalgia rheumatica and giant cell arteritis . Annals of the Rheumatic Diseases vol. 48 , ( 4 )

Kirkham BW, Pitzalis C, Kingsley GH, Timms AM, Kyriazis N, Panayi GS ( 1989 ) . Rheumatoid T lymphocyte MHC class II expression: in vitro stimulation produces normal MHC class II expression, independent of proliferation . The Journal of Rheumatology vol. 16 , ( 3 ) 270 - 275 .

Haskard DO, Strobel S, Thornhill M, Pitzalis C, Levinsky RJ ( 1989 ) . Mechanisms of lymphocyte adhesion to endothelial cells: studies using a LFA-1-deficient cell line . Immunology vol. 66 , ( 1 ) 111 - 116 .

Kingsley G, Pitzalis C, Waugh AP, Panayi GS ( 1988 ) . Correlation of immunoregulatory function with cell phenotype in cord blood lymphocytes . Clinical & Experimental Immunology vol. 73 , ( 1 ) 40 - 45 .

Kirkham B, Chikanza I, Pitzalis C, Kingsley GH, Grahame R, Gibson T, Panayi GS ( 1988 ) . RESPONSE TO MONOCLONAL CD7 ANTIBODY IN RHEUMATOID ARTHRITIS . The Lancet vol. 331 , ( 8585 )

Pitzalis C, Kingsley G, Murphy J, Panayi G ( 1987 ) . Abnormal distribution of the helper-inducer and suppressor-inducer T-lymphocyte subsets in the rheumatoid joint . Clinical Immunology vol. 45 , ( 2 ) 252 - 258 .

Kingsley GH, Pitzalis C, Panayi GS ( 1987 ) . Abnormal lymphocyte reactivity to self-major histocompatibility antigens in rheumatoid arthritis . The Journal of Rheumatology vol. 14 , ( 4 ) 667 - 673 .

Pitzalis C, Kingsley G, Lanchbury JS, Murphy J, Panayi GS ( 1987 ) . Expression of HLA-DR, DQ and DP antigens and interleukin-2 receptor on synovial fluid T lymphocyte subsets in rheumatoid arthritis: evidence for "frustrated" activation . The Journal of Rheumatology vol. 14 , ( 4 ) 662 - 666 .

Nicholas NS, Panayi GS, Murphy J, Pitzalis C ( 1986 ) . Human retroplacental sera inhibit the expression of class II major histocompatibility antigens . Journal of Reproductive Immunology vol. 9 , ( 2 ) 95 - 102 .